Neuron Quotes

Where did feelings go when they disappeared? Did they leave a chemical trace somewhere in our minds, so that if we could look inside ourselves we would see via the patterns of neurons some of the important things that had happened to us in our lifetimes?

I am a collection of oddities, a circus of neurons and electrons: my heart is the ringmaster, my soul is the trapeze artist, and the world is my audience. It sounds strange because it is, and it is, because I am strange.

I believed, and still do, that our bodies are our selves, that my soul is the voltage conducted through neurons and nerves, and that my spirit is my flesh.

Foulmouthed individuals seem to have their neuron systems replaced by colon structures, given that their terminology profusely consists of "sh*t and f*ck". ("Tolerance zero")

Whatever we call it - mind, character, soul - we like to think we possess something that is greater than the sum of our neurons and that animates us.

As a bio major, I figured "free will" meant chemicals in your brain telling you what to do, the molecules bouncing around in a way that felt like choosing but was actually the dance of little gears--neurons and hormones bubbling up into decisions like clockwork. You don't use your body; it uses you.

Any man could, if he were so inclined, be the sculptor of his own brain.

Emotional states are fairly quick bursts of neuronal gossip. Traits, on the other hand, are more like the neuronal equivalent of committed relationships.

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.

A three-day-old human embryo is a collection of 150 cells called a blastocyst. There are, for the sake of comparison, more than 100,000 cells in the brain of a fly. The human embryos that are destroyed in stem-cell research do not have brains, or even neurons. Consequently, there is no reason to believe they can suffer their destruction in any way at all. It is worth remembered, in this context, that when a person's brain has died, we currently deem it acceptable to harvest his organs (provided he has donated them for this purpose) and bury him in the ground. If it is acceptable to treat a person whose brain has died as something less than a human being, it should be acceptable to treat a blastocyst as such. If you are concerned about suffering in this universe, killing a fly should present you with greater moral difficulties than killing a human blastocyst. Perhaps you think that the crucial difference between a fly and a human blastocyst is to be found in the latter's potential to become a fully developed human being. But almost every cell in your body is a potential human being, given our recent advances in genetic engineering. Every time you scratch your nose, you have committed a Holocaust of potential human beings.

The robot had no feelings, only positronic surges that mimicked those feelings. (And perhaps human beings had no feelings, only neuronic surges that were interpreted as feelings.)

The neural processes underlying that which we call creativity have nothing to do with rationality. That is to say, if we look at how the brain generates creativity, we will see that it is not a rational process at all; creativity is not born out of reasoning.

Are You Ready for New Urban Fragrances? Yeah, I guess I'm ready, but listen: Perfume is a disguise. Since the middle ages, we have worn masks of fruit and flowers in order to conceal from ourselves the meaty essence of our humanity. We appreciate the sexual attractant of the rose, the ripeness of the orange, more than we honor our own ripe carnality. Now today we want to perfume our cities, as well; to replace their stinging fumes of disturbed fossils' sleep with the scent of gardens and orchards. Yet, humans are not bees any more than they are blossoms. If we must pull an olfactory hood over our urban environment, let it be of a different nature. I want to travel on a train that smells like snowflakes. I want to sip in cafes that smell like comets. Under the pressure of my step, I want the streets to emit the precise odor of a diamond necklace. I want the newspapers I read to smell like the violins left in pawnshops by weeping hobos on Christmas Eve. I want to carry luggage that reeks of the neurons in Einstein's brain. I want a city's gases to smell like the golden belly hairs of the gods. And when I gaze at a televised picture of the moon, I want to detect, from a distance of 239,000 miles, the aroma of fresh mozzarella.

Maybe compassion and empathy are just squishy emotions. Illusions created by our mirror neurons. But does it really matter where they come from? They make us human. They might be what make us worth saving.

Even then, more than a year earlier, there were neurons in her head, not far from her ears, that were being strangled to death, too quietly for her to hear them. Some would argue that things were going so insiduously wrong that the neurons themselves initiated events that would lead to their own destruction. Whether it was molecular murder or cellular suicide, they were unable to warn her of what was happening before they died.

Perhaps eggs are like neurons, which also are not replenished in adulthood: they know too much. Eggs must plan the party. Sperm need only to show up- wearing top hat and tails, of course.

The point is, the brain talks to itself, and by talking to itself changes its perceptions. To make a new version of the not-entirely-false model, imagine the first interpreter as a foreign correspondent, reporting from the world. The world in this case means everything out- or inside our bodies, including serotonin levels in the brain. The second interpreter is a news analyst, who writes op-ed pieces. They read each other's work. One needs data, the other needs an overview; they influence each other. They get dialogues going. INTERPRETER ONE: Pain in the left foot, back of heel. INTERPRETER TWO: I believe that's because the shoe is too tight. INTERPRETER ONE: Checked that. Took off the shoe. Foot still hurts. INTERPRETER TWO: Did you look at it? INTERPRETER ONE: Looking. It's red. INTERPRETER TWO: No blood? INTERPRETER ONE: Nope. INTERPRETER TWO: Forget about it. INTERPRETER ONE: Okay. Mental illness seems to be a communication problem between interpreters one and two. An exemplary piece of confusion. INTERPRETER ONE: There's a tiger in the corner. INTERPRETER TWO: No, that's not a tiger- that's a bureau. INTERPRETER ONE: It's a tiger, it's a tiger! INTERPRETER TWO: Don't be ridiculous. Let's go look at it. Then all the dendrites and neurons and serotonin levels and interpreters collect themselves and trot over to the corner. If you are not crazy, the second interpreter's assertion, that this is a bureau, will be acceptable to the first interpreter. If you are crazy, the first interpreter's viewpoint, the tiger theory, will prevail. The trouble here is that the first interpreter actually sees a tiger. The messages sent between neurons are incorrect somehow. The chemicals triggered are the wrong chemicals, or the impulses are going to the wrong connections. Apparently, this happens often, but the second interpreter jumps in to straighten things out.

Neurons that fire together wire together. Mental states become neural traits. Day after day, your mind is building your brain. This is what scientists call experience-dependent neuroplasticity,

Biological neurons operate at a peak speed of about 200 Hz, a full seven orders of magnitude slower than a modern microprocessor (~ 2 GHz).

God is a cluster of neurons.

The human brain, it has been said, is the most complexly organised structure in the universe and to appreciate this you just have to look at some numbers. The brain is made up of one hundred billion nerve cells or "neurons" which is the basic structural and functional units of the nervous system. Each neuron makes something like a thousand to ten thousand contacts with other neurons and these points of contact are called synapses where exchange of information occurs. And based on this information, someone has calculated that the number of possible permutations and combinations of brain activity, in other words the numbers of brain states, exceeds the number of elementary particles in the known universe.

There are two types of empathy: the positive empathy and the negative empathy. When we are fully carried away by the unaware activities of the mirror neurons, we are under the trap of negative empathy. The negative empathy generates attachments. Out of these attachments suffering follows. Negative empathy is a kind of reaction to a situation, whereas positive empathy is internal response of peace love and tranquility.... In positive empathy, your deep tranquility, joy and peace activates the mirror neurons of the others, whereas in negative empathy your mirror neurons are activated by the disturbance of others.

If we are lucky, the end of the sentence is where we might begin. If we are lucky, something is passed on, another alphabet written in the blood, sinew, and neuron; ancestors charging their kin with the silent propulsion to fly south, to turn toward the place in the narrative no one was meant to outlast.

The well-being of a neuron depends on its ability to communicate with other neurons. Studies have shown that electrical and chemical stimulation from both a neuron's inputs and its targets support vital cellular processes. Neurons unable to connect effectively with other neurons atrophy. Useless, an abandoned neuron will die.

There must be a way, I thought, that language of life as experienced-- of passion, of hunger, of love-- bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

Simulating the behavior of 100 billion neurons of human brain is not feasible by classical computer but quantum machine learning promises to fulfill that requirement.

I maintain that the human mystery is incredibly demeaned by scientific reductionism, with its claim in promissory materialism to account eventually for all of the spiritual world in terms of patterns of neuronal activity. This belief must be classed as a superstition.... we have to recognize that we are spiritual beings with souls existing in a spiritual world as well as material beings with bodies and brains existing in a material world.

Buddhist say that thoughts are like drops of water on the brain; when you reinforce the same thought, it will etch a new stream into your consciousness, like water eroding the side of a mountain. Scientist confirm this bit of folk wisdom: our neurons break connections and form new pathways all the time. Even if you've been programmed to fear death, that particular pathway isn't set in stone. Each of us is responsible for seeking out new knowledge and creating mental circuits.

...an effective psychotherapist or psychoanalyst is a "microsurgeon of the mind" who helps patients make needed alterations in neuronal networks.

What is memory? It's not something you can physically hold, or see, or smell, or taste. It's just nerve impulses jumping between neurons. Sometimes it's a matter of choice. Other times it's self-preservation, or protection" -Leight

My neurons number half a billion, and they are distributed among my eight arms. On occasion, I have wondered whether I might have more intelligence in a single tentacle than a human does in its entire skull.

As modern-day neuroscience tells us, we are never in touch with the present, because neural information-processing itself takes time. Signals take time to travel from your sensory organs along the multiple neuronal pathways in your body to your brain, and they take time to be processed and transformed into objects, scenes, and complex situations. So, strictly speaking, what you are experiencing as the present moment is actually the past.

What do we mean by "knowledge" or "understanding"? And how do billions of neurons achieve them? These are complete mysteries. Admittedly, cognitive neuroscientists are still very vague about the exact meaning of words like "understand," "think," and indeed the word "meaning" itself.

Like daffodils in the early days of spring, my neurons were resprouting receptors as the winter of the illness ebbed.

Each person you meet influences your mental universe in a way that has the potential to make a substantial impact upon the causality of the intellectual development of an entire species.

You don't stop loving someone just because they do something that surprises or even disappoints you. Maybe facts and formulas comfort Marcus, but I think that article he read was totally wrong. You don't love chemical reactions or particles or neuron receptors. You love whole people. Including the parts you didn't know were there, and the parts you're waiting for them to become.

When you travel, you're forced to have new thoughts. "Is this alley safe?" "Is this the right bus?" "Was this meat ever a house pet?" It doesn't even matter what the new thoughts are, it feels so good to just have some variety. And it's a reboot for your brain. I can feel the neurons making new connections again with new problems to solve, clawing their way back to their nimbler, younger days.

Love makes you crazy. Love crawls into your brain and plays games with your neurons. All the things you thought you knew about yourself fly out the window when love flies in.

Quantum coherence in the ion channels of the neurons and the neural circuits in the brain creates the decision behaviors and quantum cognition.

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were. And brain cells weren’t even the lower limit. The origins of thought were buried so deep they predated multicellular life itself: neurotransmitters in choanoflagellates, potassium ion gates in Monosiga. I am a colony of microbes talking to itself, Brüks reflected.

Your mind is the projection screen every writer steals; it is the firing of your neurones that makes every book come alive. You are the electricity that turns it on. A book cannot live until the touch of your hand on the first page brings it alive. A writer is essentially typing blank pages – shouting out spells in the dark – until the words are read by you, and the magic explodes into your head, and no one else's.

The brief span of an individual life is misleading. Each one of us is as old as the entire biological kingdom, and our bloodstreams are tributaries of the great sea of its total memory. The uterine odyssey of the growing foetus recapitulates the entire evolutionary past, and its central nervous system is a coded time scale, each nexus of neurones and each spinal level marking a symbolic station, a unit of neuronic time.

But evolution is not a precise mechanism, and it has resulted in a certain number of people in the population with more nerves than neurons.

Some years ago, there was a lovely philosopher of science and journalist in Italy named Giulio Giorello, and he did an interview with me. And I don’t know if he wrote it or not, but the headline in Corriere della Sera when it was published was "Sì, abbiamo un'anima. Ma è fatta di tanti piccoli robot – "Yes, we have a soul, but it’s made of lots of tiny robots." And I thought, exactly. That’s the view. Yes, we have a soul, but in what sense? In the sense that our brains, unlike the brains even of dogs and cats and chimpanzees and dolphins, our brains have functional structures that give our brains powers that no other brains have - powers of look-ahead, primarily. We can understand our position in the world, we can see the future, we can understand where we came from. We know that we’re here. No buffalo knows it’s a buffalo, but we jolly well know that we’re members of Homo sapiens, and it’s the knowledge that we have and the can-do, our capacity to think ahead and to reflect and to evaluate and to evaluate our evaluations, and evaluate the grounds for our evaluations. It’s this expandable capacity to represent reasons that we have that gives us a soul. But what’s it made of? It’s made of neurons. It’s made of lots of tiny robots. And we can actually explain the structure and operation of that kind of soul, whereas an eternal, immortal, immaterial soul is just a metaphysical rug under which you sweep your embarrassment for not having any explanation.

When the brain is working to remember something, similar patterns of neurons fire as they did during the perception of the original event. These networks are linked, and each time we revisit them, they become stronger and more associated. But they need the proper retrieval cues--words, smells, images-- for them to be brought back as memories

You die a little inside every time you have joyless sex. Neurons prune back. The good in there withers. And some things never grow back.

From a pathological standpoint, the incipient twenty-first century is determined neither by bacteria nor by viruses, but by neurons. Neurological illnesses such as depression, attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), and burnout syndrome mark the landscape of pathology at the beginning of the twenty-first century. They are not infections, but infarctions; they do not follow from the negativity of what is immunologically foreign, but from an excess of positivity. Therefore, they elude all technologies and techniques that seek to combat what is alien.

Could a machine ever be said to have made its own decisions? Could a machine have beliefs? Could a machine make mistakes? Could a machine believe it made its own decisions? Could a machine erroneously attribute free will to itself? Could a machine come up with ideas that had not been programmed into it in advance? Could creativity emerge from a set of fixed rules? Are we – even the most creative among us – but passive slaves to the laws of physics that govern our neurons?

Time is basically an illusion created by the mind to aid in our sense of temporal presence in the vast ocean of space. Without the neurons to create a virtual perception of the past and the future based on all our experiences, there is no actual existence of the past and the future. All that there is, is the present.

I guess at some point we fell in love, whatever that means. What the fuck is love anyway? Is it mutual dependance; two bipolar opposites bringing their failings together, making a comprehensive hole? Is it needing someone around all the time, just to feel like yourself? Is it a form of madness— all those cells & neurons giggling like moon-happy coyotes? Is it missing someone, feeling a physical craving for them, even when they are lying right next to you? Yes, I guess we fell in love.

Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn't it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain? Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don't want to go to Montana. How do I know I really want to go and it isn't just some neurons firing or something? Maybe it's just an accidental flash in the medulla and suddenly there I am in Montana and I find out I really didn't want to go there in the first place. I can't control what happens in my brain, so how can I be sure what I want to do ten seconds from now, much less Montana next summer? It's all this activity in the brain and you don't know what's you as a person and what's some neuron that just happens to fire or just happens to misfire.

And now all those brain cells are dead – and my mother – who in a sense was the complex electrochemical interaction of all these millions of neurons – is no more. In neuroscience it is called ‘the binding problem’ – the extraordinary fact, which nobody can even begin to explain, that mere brute matter can give rise to consciousness and sensation. I had such a strong sensation, as she lay dying, that some deeper, ‘real’ person was still there behind the death mask.

If I could fall in love with a girl, it’d be her. Those ifs are dangerous. You try them on in your head like dresses, so easy to slide in and out of. If I kissed girls, I’d kiss her. If we kissed, it’d go like this. At some point I dropped the if like a slip and just wore the feeling, nothing between it and my skin. When I kiss her. When it happens. All of it took place in my head, in silence, locked tight in skull bone and the frantic synaptic whispers between neurons, no clues popping out except the passive-aggressive haircut, the incriminating poem. That’s the problem with writers. Too much imagination. The greater part of me knew it couldn’t be real, but the hopeful part, which is more concentrated and condensed, rich in nine essential delusions, thought: It’s not all in your head.

I understand the mechanism of my own thinking. I know precisely how I know, and my understanding is recursive. I understand the infinite regress of this self-knowing, not by proceeding step by step endlessly, but by apprehending the limit. The nature of recursive cognition is clear to me. A new meaning of the term "self-aware." Fiat logos. I know my mind in terms of a language more expressive than any I'd previously imagined. Like God creating order from chaos with an utterance, I make myself anew with this language. It is meta-self-descriptive and self-editing; not only can it describe thought, it can describe and modify its own operations as well, at all levels. What Gödel would have given to see this language, where modifying a statement causes the entire grammar to be adjusted. With this language, I can see how my mind is operating. I don't pretend to see my own neurons firing; such claims belong to John Lilly and his LSD experiments of the sixties. What I can do is perceive the gestalts; I see the mental structures forming, interacting. I see myself thinking, and I see the equations that describe my thinking, and I see myself comprehending the equations, and I see how the equations describe their being comprehended. I know how they make up my thoughts. These thoughts.

Those smooth, spit-cleaned cheeks gave no indication of the dreams crowding her skull. Should she make it to adulthood, the girl would arrive with two hundred and six bones. Two and a half million sweat glands. Ninety-six thousand kilometers of blood vessels. Forty-six chromosomes. Seven meters of small intestines. Six hundred and six discrete muscles. One hundred billion cerebral neurons. Two kidneys. A liver. A heart. A hundred trillion cells that died and were replaced, again and again. But no matter how many ways she dismembered and quantified the body lying beside her, she couldn't say how many years the girl would wait before she married, if at all, or how many children she would have, if any; and between the creation of this body and its end lay the mystery the girl would spend her life solving.

The neurons that do expire are the ones that made imitation possible. When you are capable of skillful imitation, the sweep of choices before you is too large; but when your brain loses its spare capacity, and along with it some agility, some joy in winging it, and the ambition to do things that don't suit it, then you finally have to settle down to do well the few things that your brain really can do well--the rest no longer seems pressing and distracting, because it is now permanently out of reach. The feeling that you are stupider than you were is what finally interests you in the really complex subjects of life: in change, in experience, in the ways other people have adjusted to disappointment and narrowed ability. You realize that you are no prodigy, your shoulders relax, and you begin to look around you, seeing local color unrivaled by blue glows of algebra and abstraction.

What makes aerobic exercise so powerful is that it’s our evolutionary method of generating that spark. It lights a fire on every level of your brain, from stoking up the neurons’ metabolic furnaces to forging the very structures that transmit information from one synapse to the next.

The brain represented the most complex organism ever to exist, and impossible to tame. Morality could not be spawned by tweaking a few genes or shutting off a few neurons. Not yet. So though humanity conquered the very stars, it remained unable to conquer the darkness within.

It is interesting to note that although our limbic system functions throughout our lifetime, it does not mature. As a result, when our emotional "buttons" are pushed, we retain the ability to react as though we were a two year old, even when we are adults. As our higher cortical cells mature and become integrated in complex networks with other neurons, we gain the ability to take "new pictures" of the present moment. When we compare the new information of our thinking mind with the automatic reactivity of our limbic mind, we can reevaluate the current situation and purposely choose a more mature response.

...he'd know about the role of mirror neurons in the brain, special cells in the premotor cortex that fire right before a person reaches for a rock, steps forward, turns away, begins to smile.Amazingly, the same neurons fire whether we do something or watch someone else do the same thing, and both summon similar feelings. Learning form our own mishaps isn't as safe as learning from someone else's, which helps us decipher the world of intentions, making our social whirl possible. The brain evolved clever ways to spy or eavesdrop on risk, to fathom another's joy or pain quickly, as detailed sensations, without resorting to words. We feel what we see, we experience others as self.

Most of the different types of cells in our body die and are replaced every few weeks or months. However, neurons, the primary cell of the nervous system, do not multiply (for the most part) after we are born. That means that the majority of the neurons in your brain today are as old as you are. This longevity of the neurons partially accounts for why we feel pretty much the same on the inside at the age of 10 as we do at age 30 or 77.

When a monkey loses a banana to a rival, he feels bad, but he doesn't expand the problem by thinking about it over and over. He looks for another banana. He ends up feeling rewarded rather than harmed. Humans use their extra neurons to construct theories about bananas and end up constructing pain.

A study published in the October 22, 2014, issue of the journal Neuron suggests that the brain’s chemistry changes when we become curious, helping us better learn and retain information. But curiosity is uncomfortable because it involves uncertainty and vulnerability.

(...) a course laid between the seed and the snare marks of venerable syringes ordered to excite the awareness of Transcendence first and last harbour the disinfecting of exile on the bridge no one, only me, searching for approaches and testing traitor neurons grading thoughts repenting in an incomprehensible tongue and again attempting to show the splash-down of a world which moves up and down within the walls of experience a tragedy which travels unruffled hell without sinners without return (...)

The really amazing thing about all this is no matter what you believe,it took some doing to get from a point where there was nothing, to a point where all the right neurons fire and pop so that we can make decisions. More amazing is how even though that's become second nature, we all still manage to screw it up.

DON’T LEAD A DOUBLE LIFE. Everything you do takes up space in your brain. If you live a double life (and you know what I mean if I’m talking to you), then that extra life takes up neurons and synapses working overtime. The brain can’t handle it. It starts to degrade instead of grow.

We sleep, allowing gravity to hold us, allowing Earth- our larger body- to recalibrate our neurons, composting the keen encounters of our waking hours (the tensions and terrors of our individual days), stirring them back, as dreams, into the sleeping substance of our muscles. We give ourselves over to the influence of the breathing earth. Sleep is the shadow of the earth as it seeps into our skin and spreads throughout our limbs, dissolving our individual will into the thousand and one selves that compose it- cells, tissues, and organs taking their prime directives now from gravity and the wind- as residual bits of sunlight, caught in the long tangle of nerves, wander the drifting landscape of our earth-borne bodies like deer moving across the forested valleys.

At this moment, in this place, the shifting action potential in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high-precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up the optic nerves, cross the chiasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional.

It is difficult to overstate the importance of understanding mirror neurons and their function. They may well be central to social learning, imitation, and the cultural transmission of skills and attitudes—perhaps even of the pressed-together sound clusters we call words. By hyperdeveloping the mirror-neuron system, evolution in effect turned culture into the new genome. Armed with culture, humans could adapt to hostile new environments and figure out how to exploit formerly inaccessible or poisonous food sources in just one or two generations—instead of the hundreds or thousands of generations such adaptations would have taken to accomplish through genetic evolution. Thus culture became a significant new source of evolutionary pressure, which helped select brains that had even better mirror-neuron systems and the imitative learning associated with them. The result was one of the many self-amplifying snowball effects that culminated in Homo sapiens, the ape that looked into its own mind and saw the whole cosmos reflected inside.

And what science had revealed was this: Prior to treatment, patients diagnosed with schizophrenia, depression, and other psychiatric disorders do not suffer from any known "chemical imbalance". However, once a person is put on a psychiatric medication, which, in one manner or another, throws a wrench into the usual mechanics of a neuronal pathway, his or her brain begins to function, as Hyman observed, abnormally.

Mr. L. did not get better all at once. He had first to experience cycles of separations, dreams, depressions, and insights—the repetition, or 'working through,' required for long-term neuroplastic change. New ways of relating had to be learned, wiring new neurons together, and old ways of responding had to be unlearned, weakening neuronal links. Because Mr. L. had linked the ideas of separation and death, they were wired together in his neuronal networks. Now that he was conscious of his association, he could unlearn it.

Your brain needs plenty of rest to function at it's optimal level. Go to sleep!

The revolution is built on three simple facts. (1) Every human movement, thought, or feeling is a precisely timed electric signal traveling through a chain of neurons—a circuit of nerve fibers. (2) Myelin is the insulation that wraps these nerve fibers and increases signal strength, speed, and accuracy. (3) The more we fire a particular circuit, the more myelin optimizes that circuit, and the stronger, faster, and more fluent our movements and thoughts become.

He always reminded us that every atom in our bodies was once part of a distant star that had exploded. He talked about how evolution moves from simplicity toward complexity, and how human intelligence is the highest known expression of evolution. I remember him telling me that a frog's brain is much more complex than a star. He saw human consciousness as the first neuron of the universe coming to life and awareness. A spark in the darkness, waiting to spread to fire.

In fact, the belief that neurophysiology is even relevant to the functioning of the mind is just hypothesis. Who knows if we're looking at the right aspects of the brain at all. Maybe there are other aspects of the brain that nobody has even dreamt of looking at yet. That's often happened in the history of science. When people say that the mental is the neurophysiological at a higher level, they're being radically unscientific. We know a lot about the mental from a scientific point of view. We have explanatory theories that account for a lot of things. The belief that neurophysiology is implicated in these things could be true, but we have every little evidence for it. So, it's just a kind of hope; look around and you see neurons; maybe they're implicated.

Some researchers have proposed that experiencing empathy and compassion through the mirror neuron system is equivalent to having compassion for yourself. Thus, “giving is receiving ” is a brain-based truth. Insensitivity and selfishness are essentially bad for your brain and your mental health. In contrast, compassion and loving relationships are good for your brain and your mental health.

Every age has its signature afflictions. Thus, a bacterial age existed; at the latest, it ended with the discovery of antibiotics. Despite widespread fear of an influenza epidemic, we are not living in a viral age. Thanks to immunological technology, we have already left it behind. From a pathological standpoint, the incipient twenty-first century is determined neither by bacteria nor by viruses, but by neurons. Neurological illnesses such as depression, attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), and burnout syndrome mark the landscape of pathology at the beginning of the twenty-first century.

Kandel argues that when psychotherapy changes people, 'it presumably does so through learning, by producing changes in gene expression that alter the strength of synaptic connections, and structural changes that alter the anatomical pattern of interconnections between nerve cells of the brain.' Psychotherapy works by going deep into the brain and its neurons and changing their structure by turning on the right genes. Psychiatrist Dr. Susan Vaughan has argued that the talking cure works by 'talking to neurons,' and that an effective psychotherpist or psychoanalyst is a 'microsurgeon of the mind' who helps patients make needed alterations in neuronal networks.

My mitochondria comprise a very large proportion of me. I cannot do the calculation, but I suppose there is almost as much of them in sheer dry bulk as there is the rest of me. Looked at in this way, I could be taken for a very large, motile colony of respiring bacteria, operating a complex system of nuclei, microtubules, and neurons for the pleasure and sustenance of their families, and running, at the moment, a typewriter.

Then let me tell you something instead. When they make an Envoy, do you want to know what they do? They burn out every evolved violence limitation instinct in the human psyche. Submission signal recognition, pecking-order dynamics, pack loyalties. It all goes, tuned out a neuron at a time; and they replace it with a conscious will to harm.” He stared back at me in silence. “Do you understand me? It would have been easier to kill you just then. It would have been easier. I had to stop myself. That’s what an Envoy is, Curtis. A reassembled human. An artifice.

If you want to see philosophy in action, pay a visit to a robo-rat laboratory. A robo-rat is a run-ofthe-mill rat with a twist: scientists have implanted electrodes into the sensory and reward areas in the rat’s brain. This enables the scientists to manoeuvre the rat by remote control. After short training sessions, researchers have managed not only to make the rats turn left or right, but also to climb ladders, sniff around garbage piles, and do things that rats normally dislike, such as jumping from great heights. Armies and corporations show keen interest in the robo-rats, hoping they could prove useful in many tasks and situations. For example, robo-rats could help detect survivors trapped under collapsed buildings, locate bombs and booby traps, and map underground tunnels and caves. Animal-welfare activists have voiced concern about the suffering such experiments inflict on the rats. Professor Sanjiv Talwar of the State University of New York, one of the leading robo-rat researchers, has dismissed these concerns, arguing that the rats actually enjoy the experiments. After all, explains Talwar, the rats ‘work for pleasure’ and when the electrodes stimulate the reward centre in their brain, ‘the rat feels Nirvana’. To the best of our understanding, the rat doesn’t feel that somebody else controls her, and she doesn’t feel that she is being coerced to do something against her will. When Professor Talwar presses the remote control, the rat wants to move to the left, which is why she moves to the left. When the professor presses another switch, the rat wants to climb a ladder, which is why she climbs the ladder. After all, the rat’s desires are nothing but a pattern of firing neurons. What does it matter whether the neurons are firing because they are stimulated by other neurons, or because they are stimulated by transplanted electrodes connected to Professor Talwar’s remote control? If you asked the rat about it, she might well have told you, ‘Sure I have free will! Look, I want to turn left – and I turn left. I want to climb a ladder – and I climb a ladder. Doesn’t that prove that I have free will?

It [the mind] can make a heaven of hell or a hell of heaven.” In our constant search for meaning in this baffling and temporary existence, trapped as we are within our three pounds of neurons, it is sometimes hard to tell what is real. We often invent what isn’t there. Or ignore what is. We try to impose order, both in our minds and in our conceptions of external reality. We try to connect. We try to find truth. We dream and we hope. And underneath all of these strivings, we are haunted by the suspicion that what we see and understand of the world is only a tiny piece of the whole.

Our brains contain one hundred billion nerve cells (neurons). Each neuron makes links with ten thousand other neurons to form an incredible three dimensional grid. This grid therefore contains a thousand trillion connections - that's 1,000,000,000,000,000 (a quadrillion). It's hard to imagine this, so let's visualise each connection as a disc that's 1mm thick. Stack up the quadrillion discs on top of each other and they will reach the sun (which is ninety-three million miles from the earth) and back, three times over.

That wasn’t a true dream, but an ancient organic memory millions of years old. The innate releasing mechanisms laid down in your cytoplasm have been awakened. The expanding sun and rising temperatures are driving you back down to the spinal levels into the drowned seas of the lowest layers of your unconscious, into the entirely new zone of the neuronic psyche. This is the lumbar transfer, total psychic recall. We really remember these swamps and lagoons.

Examples of fractals are everywhere in nature. They can be found in the patterns of trees, branches, and ferns, in which each part appears to be a smaller image of the whole. They are found in the branch-like patterns of river systems, lightning, and blood vessels. They can be seen in snowflakes, seashells, crystals, and mountain ranges. We can even see the holographic and fractal-like nature of reality in the structure of the Universe itself, as the clusters of galaxies and dark matter resemble the neurons in our brain, the mycelium network of fungi, as well as the network of the man-made Internet.

Just like we need food and water, humans need each other. A brain study revealed that when placed in an MRI, a patient's reward center lit up when another person sat in the room. Neurons fire when talk to someone, think about someone, and they go haywire when we hold someone's hand. Our brains and bodies are actually programmed to seek each other out and connect. So then why do so many people prefer being alone? Why do we often run for the hills when we feel the slightest connection? Why we do we feel compelled to fight what we're hardwired to do? Maybe it's because when we find someone or something to hold on to, that feeling becomes like air. And we're terrified we're going to lose it. And trust me, you can get pretty good at the alone thing. But most things are better when they're shared with someone else.

Inspirations sleet through the universe continuously. Their destination, as if they cared, is the right mind in the right place at the right time. They hit the right neuron, there's a chain reaction, and a little while later someone is blinking furiously in the TV lights and wondering how the hell he came up with the idea of pre-sliced bread in the first place. Leonard of Quirm knew about inspirations. One of his earliest inventions was an earthed metal nightcap, worn in the hope that the damned things would stop leaving their white-hot trails across his tortured imagination. It seldom worked. He knew the shame of waking up to find the sheets covered with nocturnal sketches of seige engines for apple-peeling machines.

It might not be immediately obvious to some readers why the ability to perform 10^85 computational operations is a big deal. So it's useful to put it in context. [I]t may take about 10^31-10^44 operations to simulate all neuronal operations that have occurred in the history of life on Earth. Alternatively, let us suppose that the computers are used to run human whole brain emulations that live rich and happy lives while interacting with one another in virtual environments. A typical estimate of the computational requirements for running one emulation is 10^18 operations per second. To run an emulation for 100 subjective years would then require some 10^27 operations. This would be mean that at least 10^58 human lives could be created in emulation even with quite conservative assumptions about the efficiency of computronium. In other words, assuming that the observable universe is void of extraterrestrial civilizations, then what hangs in the balance is at least 10,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 human lives. If we represent all the happiness experienced during one entire such life with a single teardrop of joy, then the happiness of these souls could fill and refill the Earth's oceans every second, and keep doing so for a hundred billion billion millennia. It is really important that we make sure these truly are tears of joy.

In an extreme view, the world can be seen as only connections, nothing else. We think of a dictionary as the repository of meaning, but it defines words only in terms of other words. I liked the idea that a piece of information is really defined only by what it's related to, and how it's related. There really is little else to meaning. The structure is everything. There are billions of neurons in our brains, but what are neurons? Just cells. The brain has no knowledge until connections are made between neurons. All that we know, all that we are, comes from the way our neurons are connected.

Consider an AI that has hedonism as its final goal, and which would therefore like to tile the universe with “hedonium” (matter organized in a configuration that is optimal for the generation of pleasurable experience). To this end, the AI might produce computronium (matter organized in a configuration that is optimal for computation) and use it to implement digital minds in states of euphoria. In order to maximize efficiency, the AI omits from the implementation any mental faculties that are not essential for the experience of pleasure, and exploits any computational shortcuts that according to its definition of pleasure do not vitiate the generation of pleasure. For instance, the AI might confine its simulation to reward circuitry, eliding faculties such as a memory, sensory perception, executive function, and language; it might simulate minds at a relatively coarse-grained level of functionality, omitting lower-level neuronal processes; it might replace commonly repeated computations with calls to a lookup table; or it might put in place some arrangement whereby multiple minds would share most parts of their underlying computational machinery (their “supervenience bases” in philosophical parlance). Such tricks could greatly increase the quantity of pleasure producible with a given amount of resources.

Every unique thing in nature is related to the whole, and partakes of the perfection of the whole. Each particle is a microcosm, and faithfully renders the likeness of the world. In geometric harmony of the cosmos there are ways that resemble, there are universal patterns, from blood vessels, to winter trees or to a river delta, from nautilus shell to spiral galaxy, from neurons in the brain to the cosmic web. A whole universe of connections is in your mind – a universe within a universe – and one capable of reaching out to the other that gave rise to it. Billions of neurons touching billions of stars – surely spiritual.

Sebastian ran a finger over the spines of the books on the shelf. It did not matter to him what the titles were. They were books. They were filled with thoughts. Their relevance was debatable; he was sure some were exceptional while others were the works of lesser minds. He was not above calling a book unreadable. But their literary merit wasn’t important at this moment. They were words strung together to represent the firing of neurons and the transferring of information through synapses. They were human minds set into paper, and Sebastian loved every single one of them, even the ones he found disposable.

As graduation loomed, I had a nagging sense that there was still far too much unresolved for me, that I wasn’t done studying. I applied for a master’s in English literature at Stanford and was accepted into the program. I had come to see language as an almost supernatural force, existing between people, bringing our brains, shielded in centimeter-thick skulls, into communion. A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans—i.e., “human relationality”—that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced—of passion, of hunger, of love—bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

It was Freud's ambition to discover the cause of hysteria, the archetypal female neurosis of his time. In his early investigations, he gained the trust and confidence of many women, who revealed their troubles to him.Time after time, Freud's patients, women from prosperous, conventional families, unburdened painful memories of childhood sexual encounters with men they had trusted: family friends, relatives, and fathers. Freud initially believed his patients and recognized the significance of their confessions. In 1896, with the publication of two works, The Aetiology of Hysteria and Studies on Hysteria, he announced that he had solved the mystery of the female neurosis. At the origin of every case of hysteria, Freud asserted, was a childhood sexual trauma. But Freud was never comfortable with this discovery, because of what it implied about the behavior of respectable family men. If his patients' reports were true, incest was not a rare abuse, confined to the poor and the mentally defective, but was endemic to the patriarchal family. Recognizing the implicit challenge to patriarchal values, Freud refused to identify fathers publicly as sexual aggressors. Though in his private correspondence he cited "seduction by the father" as the "essential point" in hysteria, he was never able to bring himself to make this statement in public. Scrupulously honest and courageous in other respects, Freud falsified his incest cases. In The Aetiology of Hysteria, Freud implausibly identified governessss, nurses, maids, and children of both sexes as the offenders. In Studies in Hysteria, he managed to name an uncle as the seducer in two cases. Many years later, Freud acknowledged that the "uncles" who had molested Rosaslia and Katharina were in fact their fathers. Though he had shown little reluctance to shock prudish sensibilities in other matters, Freud claimed that "discretion" had led him to suppress this essential information. Even though Freud had gone to such lengths to avoid publicly inculpating fathers, he remained so distressed by his seduction theory that within a year he repudiated it entirely. He concluded that his patients' numerous reports of sexual abuse were untrue. This conclusion was based not on any new evidence from patients, but rather on Freud's own growing unwillingness to believe that licentious behavior on the part of fathers could be so widespread. His correspondence of the period revealed that he was particularly troubled by awareness of his own incestuous wishes toward his daughter, and by suspicions of his father, who had died recently. p9-10

There has been more bloodshed in the name of God than for any other cause. And it is all because people never attempt to reach the fountain-head. They are content only to comply with the customs of their forefathers and instructions on some books, and want others to do the same. But, to explain God after merely reading the scriptures is like explaining the city of New York after seeing it only in a map.

Individuality is deeply imbued in us from the very start, at the neuronal level. Even at a motor level, researchers have shown, an infant does not follow a set pattern of learning to walk or how to reach for something. Each baby experiments with different ways of reaching for objects and over the course of several months discovers or selects his own motor solutions. When we try to envisage the neural basis of such individual learning, we might imagine a "population" of movements (and their neural correlates) being strengthened or pruned away by experience. Similar considerations arise with regard to recover and rehabilitation after strokes and other injuries. There are no rules; there is no prescribed path of recovery; every patient must discover or create his own motor and perceptual patterns, his own solutions to the challenges that face him; and it is the function of a sensitive therapist to help him in this. And in its broadest sense, neural Darwinism implies that we are destined, whether we wish it or not, to a life of particularity and self-development, to make our own individual paths through life.

Humans have always exalted dreams. Pindar of Thebes, the Greek lyric poet, suggested that the soul is more active while dreaming than while awake. He believed that during a dream, the awakened soul may see the future, “an award of joy or sorrow drawing near.” So it’s no wonder that humans were quick to reserve dreams for people alone; researchers for many years claimed dreams were a property of “higher” minds. But any pet owner who has heard her dog woof or seen his cat twitch during sleep knows that is not true. MIT researchers now know not only that rats dream, but what they dream about. Neurons in the brain fire in distinctive patterns while a rat in a maze performs particular tasks. The researchers repeatedly saw the exact same patterns reproduced while the rats slept—so clearly that they could tell what point in the maze the rat was dreaming about, and whether the animal was running or walking in the dream. The rats’ dreams took place in an area of the brain known to be involved with memory, further supporting a notion that one function of dreams is to help an animal remember what it has learned.

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.” Helena leans forward, snaps her fingers. “Just what your brain does to interpret a simple stimulus like that is incredible. The visual and auditory information arrive at your eyes and ears at different speeds, and then are processed by your brain at different speeds. Your brain waits for the slowest bit of stimulus to be processed, then reorders the neural inputs correctly, and lets you experience them together, as a simultaneous event—about half a second after what actually happened. We think we’re perceiving the world directly and immediately, but everything we experience is this carefully edited, tape-delayed reconstruction.

First, contrary to popular belief, Buddhists can actually be very anxious people. That’s often why they become Buddhists in the first place. Buddhism was made for the anxious like Christianity was made for the downtrodden or AA for the addicted. Its entire purpose is to foster equanimity, to tame excesses of thought and emotion. The Buddhists have a great term for these excesses. They refer to them as the condition of “monkey mind.” A person in the throes of monkey mind suffers from a consciousness whose constituent parts will not stop bouncing from skull-side to skull-side, which keep flipping and jumping and flinging feces at the walls and swinging from loose neurons like howlers from vines. Buddhist practices are designed explicitly to collar these monkeys of the mind and bring them down to earth—to pacify them. Is it any wonder that Buddhism has had such tremendous success in the bastions of American nervousness, on the West Coast and in the New York metro area?

But now I speculate re the ants' invisible organ of aggregate thought... if, in a city park of broad reaches, winding paths, roadways, and lakes, you can imagine seeing on a warm and sunny Sunday afternoon the random and unpredictable movement of great numbers of human beings in the same way... if you watch one person, one couple, one family, a child, you can assure yourself of the integrity of the individual will and not be able to divine what the next moment will bring. But when the masses are celebrating a beautiful day in the park in a prescribed circulation of activities, the wider lens of thought reveals nothing errant, nothing inconstant or unnatural to the occasion. And if someone acts in a mutant un-park manner, alarms go off, the unpredictable element, a purse snatcher, a gun wielder, is isolated, surrounded, ejected, carried off as waste. So that while we are individually and privately dyssynchronous, moving in different ways, for different purposes, in different directions, we may at the same time comprise, however blindly, the pulsing communicating cells of an urban over-brain. The intent of this organ is to enjoy an afternoon in the park, as each of us street-grimy urbanites loves to do. In the backs of our minds when we gather for such days, do we know this? How much of our desire to use the park depends on the desires of others to do the same? How much of the idea of a park is in the genetic invitation on nice days to reflect our massive neuromorphology? There is no central control mechanism telling us when and how to use the park. That is up to us. But when we do, our behavior there is reflective, we can see more of who we are because of the open space accorded to us, and it is possible that it takes such open space to realize in simple form the ordinary identity we have as one multicellular culture of thought that is always there, even when, in the comparative blindness of our personal selfhood, we are flowing through the streets at night or riding under them, simultaneously, as synaptic impulses in the metropolitan brain. Is this a stretch? But think of the contingent human mind, how fast it snaps onto the given subject, how easily it is introduced to an idea, an image that it had not dreamt of thinking of a millisecond before... Think of how the first line of a story yokes the mind into a place, a time, in the time it takes to read it. How you can turn on the radio and suddenly be in the news, and hear it and know it as your own mind's possession in the moment's firing of a neuron. How when you hear a familiar song your mind adopts its attitudinal response to life before the end of the first bar. How the opening credits of a movie provide the parameters of your emotional life for its ensuing two hours... How all experience is instantaneous and instantaneously felt, in the nature of ordinary mind-filling revelation. The permeable mind, contingently disposed for invasion, can be totally overrun and occupied by all the characteristics of the world, by everything that is the case, and by the thoughts and propositions of all other minds considering everything that is the case... as instantly and involuntarily as the eye fills with the objects that pass into its line of vision.