Slow Metabolism Quotes

You think man can destroy the planet? What intoxicating vanity. Let me tell you about our planet. Earth is four-and-a-half-billion-years-old. There's been life on it for nearly that long, 3.8 billion years. Bacteria first; later the first multicellular life, then the first complex creatures in the sea, on the land. Then finally the great sweeping ages of animals, the amphibians, the dinosaurs, at last the mammals, each one enduring millions on millions of years, great dynasties of creatures rising, flourishing, dying away -- all this against a background of continuous and violent upheaval. Mountain ranges thrust up, eroded away, cometary impacts, volcano eruptions, oceans rising and falling, whole continents moving, an endless, constant, violent change, colliding, buckling to make mountains over millions of years. Earth has survived everything in its time. It will certainly survive us. If all the nuclear weapons in the world went off at once and all the plants, all the animals died and the earth was sizzling hot for a hundred thousand years, life would survive, somewhere: under the soil, frozen in Arctic ice. Sooner or later, when the planet was no longer inhospitable, life would spread again. The evolutionary process would begin again. It might take a few billion years for life to regain its present variety. Of course, it would be very different from what it is now, but the earth would survive our folly, only we would not. If the ozone layer gets thinner, ultraviolet radiation sears the earth, so what? Ultraviolet radiation is good for life. It's powerful energy. It promotes mutation, change. Many forms of life will thrive with more UV radiation. Many others will die out. Do you think this is the first time that's happened? Think about oxygen. Necessary for life now, but oxygen is actually a metabolic poison, a corrosive glass, like fluorine. When oxygen was first produced as a waste product by certain plant cells some three billion years ago, it created a crisis for all other life on earth. Those plants were polluting the environment, exhaling a lethal gas. Earth eventually had an atmosphere incompatible with life. Nevertheless, life on earth took care of itself. In the thinking of the human being a hundred years is a long time. A hundred years ago we didn't have cars, airplanes, computers or vaccines. It was a whole different world, but to the earth, a hundred years is nothing. A million years is nothing. This planet lives and breathes on a much vaster scale. We can't imagine its slow and powerful rhythms, and we haven't got the humility to try. We've been residents here for the blink of an eye. If we're gone tomorrow, the earth will not miss us.

Metabolism slows down 90 percent after 30 minutes of sitting.

Whenever I see fat people, they're eating," I ruminated safely out of the diner's earshot. "Don't give me this it's glands or genes or a slow metabolism rubbish. It's food. They're fat because they eat the wrong food, too much of it, and all the time.

We all behave like Maxwell’s demon. Organisms organize. In everyday experience lies the reason sober physicists across two centuries kept this cartoon fantasy alive. We sort the mail, build sand castles, solve jigsaw puzzles, separate wheat from chaff, rearrange chess pieces, collect stamps, alphabetize books, create symmetry, compose sonnets and sonatas, and put our rooms in order, and all this we do requires no great energy, as long as we can apply intelligence. We propagate structure (not just we humans but we who are alive). We disturb the tendency toward equilibrium. It would be absurd to attempt a thermodynamic accounting for such processes, but it is not absurd to say we are reducing entropy, piece by piece. Bit by bit. The original demon, discerning one molecules at a time, distinguishing fast from slow, and operating his little gateway, is sometimes described as “superintelligent,” but compared to a real organism it is an idiot savant. Not only do living things lessen the disorder in their environments; they are in themselves, their skeletons and their flesh, vesicles and membranes, shells and carapaces, leaves and blossoms, circulatory systems and metabolic pathways - miracles of pattern and structure. It sometimes seems as if curbing entropy is our quixotic purpose in the universe.

You think this is the first time such a thing has happened? Don’t you know about oxygen?” “I know it’s necessary for life.” “It is now,” Malcolm said. “But oxygen is actually a metabolic poison. It’s a corrosive gas, like fluorine, which is used to etch glass. And when oxygen was first produced as a waste product by certain plant cells—say, around three billion years ago—it created a crisis for all other life on our planet. Those plant cells were polluting the environment with a deadly poison. They were exhaling a lethal gas, and building up its concentration. A planet like Venus has less than one percent oxygen. On earth, the concentration of oxygen was going up rapidly—five, ten, eventually twenty-one percent! Earth had an atmosphere of pure poison! Incompatible with life!” Hammond looked irritated. “So what is your point? That modern pollutants will be incorporated, too?” “No,” Malcolm said. “My point is that life on earth can take care of itself. In the thinking of a human being, a hundred years is a long time. A hundred years ago, we didn’t have cars and airplanes and computers and vaccines.… It was a whole different world. But to the earth, a hundred years is nothing. A million years is nothing. This planet lives and breathes on a much vaster scale. We can’t imagine its slow and powerful rhythms, and we haven’t got the humility to try. We have been residents here for the blink of an eye. If we are gone tomorrow, the earth will not miss us.

You don’t get fat because your metabolism slows; your metabolism slows because you’re getting fat.

One of the things that happens is that during sleep, your brain cleans itself of waste that has accumulated during the day. “During slow-wave sleep, your cerebral spinal fluid channels open up more and remove metabolic waste from your brain,” Roxanne explained to me. Every night, when you go to sleep, your brain is rinsed with a watery fluid. This cerebrospinal fluid washes through your brain, flushing out toxic proteins and carrying them down to your liver to get rid of them. “So when I’m talking to college students, I call this brain-cell poop. If you can’t focus well, it might be you have too much brain-cell poop circulating.” That can explain why, when you are tired, “you get a hung-over sort of feeling”—you are literally clogged up with toxins. This positive kind of brainwashing can only happen when you are asleep.

The biggest offenders are seeds like flax and sesame seeds, and cruciferous vegetables like broccoli, cauliflower, cabbage, and Brussels sprouts.

According to Dr. Ray Peat, nutritional researcher and biologist, ideal heart rates for a healthy metabolism should range between 75 and 90 bpm. Despite

The problem with being an adult is absolutely everything. Bills. Work. The bone-crushing disappointment that comes from knowing the guy you want isn’t right for you. A slowed metabolism.

First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so you move less and conserve energy) and hungry (so you eat more), and it slows down your metabolism (so you don’t die!). This “eat less, exercise more” formula is not too successful for most people. It can work for a short time, certainly, but less than 10 percent of people lose weight and keep it off for a year;4 you will almost always rebound and gain back the weight. Second, when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving. The only thing that can stop this vicious cycle is eating a lot of fat and cutting out the refined carbs and sugar. A high-fat, low-carb diet leads to a faster metabolism and sustained weight loss.

A study published in the Proceedings of the National Academy of Sciences found that restricting calories by 30 percent significantly increased life span in monkeys.27 The experimental diet, while still providing adequate nourishment, slowed monkeys’ metabolism and reduced their body temperatures, changes similar to those in the long-lived thin mice. Decreased levels of triglycerides and increased HDL (the good) cholesterol were also observed. Studies over the years, on many different species of animals, have confirmed that those animals that were fed less lived longest. In fact, allowing an animal to eat as much food as it desires can reduce its life span by as much as one-half.

Yogasanas have often been thought of as a form of exercise. They are not exercises, but techniques which place the physical body in positions that cultivate awareness, relaxation, concentration and meditation. Part of this process is the development of good physical health by stretching, massaging and stimulating the pranic channels and internal organs. When yogasanas are performed, respiration and metabolic rates slow down, the consumption of oxygen and the body temperature drop. During exercise, however, the breath and metabolism speed up, oxygen consumption rises, and the body gets hot. In addition, asanas are designed to have specific effects on the glands and internal organs, and to alter electrochemical activity in the nervous system.

BORN TO RUN In his book Racing the Antelope: What Animals Can Teach Us about Running and Life, biologist Bernd Heinrich describes the human species as an endurance predator. The genes that govern our bodies today evolved hundreds of thousands of years ago, when we were in constant motion, either foraging for food or chasing antelope for hours and days across the plains. Heinrich describes how, even though antelope are among the fastest mammals, our ancestors were able to hunt them down by driving them to exhaustion—keeping on their tails until they had no energy left to escape. Antelope are sprinters, but their metabolism doesn’t allow them to go and go and go. Ours does. And we have a fairly balanced distribution of fast-twitch and slow-twitch muscle fibers, so even after ranging miles over the landscape we retain the metabolic capacity to sprint in short bursts to make the kill.

According to Dr. Barnes, a healthy body temperature should be 97.8 degrees Farenheit (36.6 degrees Celsius) upon rising. Body temperature should steadily rise during the day and peak mid-day to about 98.6 degrees F (37 degrees C). Anything below that could indicate a sign of a sluggish metabolism.

Obvious variations aside, there's only one human body. 206 bones, five major organs, 60,000 miles of blood vessels. All it takes is time. Days. Months. Years, spent memorizing the finite ways there are to hurt and break a man. Preparing for all of them. I've escaped from every conceivable deathtrap. Ten times. A dozen times. I can slow my breathing and metabolism to control panic and conserve air. Straitjacket's kindergarten. Locks, too. Benchpressing a pine coffin lid through 600 pounds of loose soil that's filling your mouth, crushing your lungs flat, and shredding your dehydrated muscles? That's harder. But far from impossible.

Methionine is also an essential amino acid needed for growth and development. However, when it comes to longevity in life, research has found that rats eating a methionine-restrictive diet lived 43-percent longer than those that consume a diet high in methionine. Methionine is known for its thyroid-suppressing properties like cysteine

So our food’s safe, right? But what if it acts more like a slow poison, like cigarettes—one won’t kill you, but ten thousand consumed over ten years might? Unlike Salmonella, you won’t be feeling the effects immediately. But eventually, you’ll feel it . . . everywhere. In your heart, muscles, bladder, brain, and especially your wallet.

The metabolic rate of history is too fast for us to observe it. It's as if, attending to the day-long life cycle of a single mayfly, we lose sight of the species and its fate. At the same time, the metabolic rate of geology is too slow for us to perceive it, so that, from birth to death, it seems to us who are caught in the beat of our own individual human hearts that everything happening on this planet is what happens to us, personally, privately, secretly. We can stand at night on a high, cold plain and look out toward the scrabbled, snow-covered mountains in the west, the same in a suburb of Denver as outside a village in Baluchistan in Pakistan, and even though beneath our feet continent-sized chunks of earth grind inexorably against one another, go on driving one or the other continent down so as to rise up and over it, as if desiring to replace it on the map, we poke with our tongue for a piece of meat caught between two back teeth and think of sarcastic remarks we should have made to our brother-in-law at dinner.

the odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. To achieve longevity—to live longer and live better for longer—we must understand and confront these causes of slow death.

Do people really drown and come to life again? Well, not really, but it can seem so. The mammalian dive reflex is triggered when a person is suddenly submerged, face and body, into very cold water. The body’s metabolism slows as the reflex redirects circulation away from the limbs and routes blood between the heart, brain, and lungs only. The heart can beat more slowly and oxygen is conserved for essential bodily processes, so as to maintain life for as long as possible. Once recovered from the water, the near-drowned person will appear dead. This physiological phenomenon was first written up in the medical journals in the middle of the twentieth century. The dive reflex is thought to occur in all mammals, both terrestrial and aquatic. It has been observed in adult humans but is believed to be most dramatic in small children.

Diets don’t work because they require us to live in a constant state of war with our bodies. “Whenever you restrict food intake, you’re going to run up against your own biology,” explains Dr. Sharma. “It doesn’t matter what program you follow. As soon as your body senses that there are fewer calories going in than going out, it harnesses a whole array of defense mechanisms to fight that.” When we’re dieting, our bodies try to conserve energy, so our metabolism slows down, the result being that you have to eat even less to keep losing weight. That becomes an increasingly difficult project because our bodies also produce more of the hormones, such as ghrelin, that trigger hunger. There is even some evidence that the bacteria in our guts respond when we eat fewer calories, shifting their populations in ways that will send more hunger signals to our brains.

We have witnessed hundreds of clients and patients damage their metabolic and hormonal health through low-carb diets. It is becoming increasingly apparent that there is an epidemic of metabolic and hormonal dysfunction emerging in the hordes of people who have been following low-carb diets. This is particularly impactful for women—and especially physically active women—who commonly suffer side effects from their low-carb diets, including: A stopped or irregular menstrual cycle (amenorrhea)418 419 420 421 422 Decreased fertility423 424 425 Hypoglycemic episodes and blood sugar swings426 Depression, anxiety, and irritability427 428 429 Poor libido430 431 432 Disrupted sleep/insomnia433 434 Dysfunctional relationship with food and fear about eating either fat or carbohydrate435 436 Cycles of restriction and binges437 438 Chronic fatigue 439 440 441 442 Poor thyroid function (and a slow metabolism)443 444 445 446 447 448

You start to realize exercise is no longer about vanity, but necessity. Your metabolism changes too, sadly starting to slow down. You start to realize you ‘should’ go easier on the cheese boards, but you won’t because brie is everything. Then there are the hangovers! Drinking two bottles of Prosecco doesn’t feel like having a beaker of lemonade any more – it fizzes and pops and aches in your head the next day; but fortunately you have more willpower now to ‘get on with it’.

Our body is like a machine. If we constantly run the machinery at high speed, it will wear out faster. Since animals with slower metabolic rates live longer, eating more calories, which drives up our metabolic rate, will cause us only to age faster. Contrary to what you may have heard and read in the past, our goal should be the opposite: to eat less, only as much as we need to maintain a slim and muscular weight, and no more, so as to keep our metabolic rate relatively slow.

I ran to Sailor’s hutch to see if he’d made it through alive. He was backed into the corner, shivering, and in the most wretched condition: he had become so malnourished that his fur had grown horribly long, his body’s attempt to compensate for his slow metabolism and low temperature. His claws were an inch long, and worse, his front teeth had curled over his lower lip so he could hardly open his mouth. Apparently, rabbits need to be chewing on hard things like carrots; otherwise their teeth will grow. Terrified, I opened the cage door to hug little Sailor, but, in a spastic fury, he started scratching my face and neck. I still have the scars. Without anyone attending to him, he had gone feral. That’s what’s happened to me, in Seattle. Come at me, even in love, and I’ll scratch the hell out of you. ’Tis a piteous fate to have befallen a MacArthur genius, wouldn’t you say? Poof. But I do love you, Bernadette TUESDAY, DECEMBER 14 From Paul Jellinek Bernadette, Are you done?

The explanation may be that gene activity in our muscles changes when the muscles don’t contract for long periods of time. In one experiment, researchers at the University of Massachusetts asked a group of healthy young men to walk around using crutches such that the muscles in their left legs never contracted. After only two days of inactivity, the scientists biopsied muscles in both legs. In the left leg, the DNA repair mechanism had been disrupted, insulin response was dropping, oxidative stress was rising, and metabolic activity within individual muscle cells was slowing.

In 2007, Jeffrey Flier, dean of Harvard Medical School and his wife and colleague in obesity research, Terry Maratos-Flier, published an article in Scientific American called “What Fuels Fat.” In it, they described the intimate link between appetite and energy expenditure, making clear that they are not simply variables that an individual can consciously decide to change with the only effect being that his or her fat tissue will get smaller or larger to compensate. An animal whose food is suddenly restricted tends to reduce its energy expenditure both by being less active and by slowing energy use in cells, thereby limiting weight loss. It also experiences increased hunger so that once the restriction ends, it will eat more than its prior norm until the earlier weight is attained. What the Fliers accomplished in just two sentences is to explain why a hundred years of intuitively obvious dietary advice—eat less—doesn’t work in animals. If we restrict the amount of food an animal can eat (we can’t just tell it to eat less, we have to give it no choice), not only does it get hungry, but it actually expends less energy. Its metabolic rate slows down. Its cells burn less energy (because they have less energy to burn). And when it gets a chance to eat as much as it wants, it gains the weight right back. The

All time, Father once told her, is relative: because of the speed the Argos travels, the ship clock kept by Sybil runs faster than clocks back on Earth. The chronometers that run inside every human cell that tell us it’s time to get drowsy, to make a baby, to grow old—all these clocks, Father said, can be altered by speed, software, or circumstance. Some dormant seeds, he said, like the ones in the drawers in Farm 4, can stop time for centuries, slowing their metabolisms to almost zero, sleeping away the seasons, until the right combination of moisture and temperature appears, and the right wavelength of sunlight penetrates the soil. Then, as though you spoke the magic words: they open.

As I said, if I don’t do anything I tend to put on the pounds. My wife’s the opposite, since she can eat as much as she likes (she doesn’t eat a lot of them, but can never turn down anything sweet), never exercise, and still not put on any weight. She has no extra fat at all. Life just isn’t fair, is how it used to strike me. Some people can work their butts off and never get what they’re aiming for, while others can get it without any effort at all. But when I think about it, having the kind of body that easily puts on weight was perhaps a blessing in disguise. In other words, if I don’t want to gain weight I have to work out hard every day, watch what I eat, and cut down on indulgences. Life can be tough, but as long as you don’t stint on the effort, your metabolism will greatly improve with these habits, and you’ll end up much healthier, not to mention stronger. To a certain extent, you can even slow down the effects of aging. But people who naturally keep the weight off no matter what don’t need to exercise or watch their diet in order to stay trim. There can’t be many of them who would go out of their way to take these troublesome measures when they don’t need to. Which is why, in many cases, their physical strength deteriorates as they age. If you don’t exercise, your muscles will naturally weaken, as will your bones. Some of my readers may be the kind of people who easily gain weight, but the only way to understand what’s really fair is to take a long-range view of things. For the reasons I give above, I think this physical nuisance should be viewed in a positive way, as a blessing. We should consider ourselves lucky that the red light is so clearly visible.

The most general formula on which every religion and morality is founded is: "Do this and that, refrain from this and that — and then you will be happy! And if you don't..." Every morality, every religion, is based on this imperative; I call it the original sin of reason, the immortal unreason. In my mouth, this formula is changed into its opposite — the first example of my "revaluation of all values." An admirable human being, a "happy one," instinctively must perform certain actions and avoid other actions; he carries these impulses in his body, and they determine his relations with the world and other human beings. In a formula: his virtue is the effect of his happiness. A long life, many descendants — these are not the rewards of virtue: instead, virtue itself is that slowing down of the metabolism which leads, among other things, to a long life, many descendants — in short, to Cornaro's virtue.

Metabolism is oxygen. And oxygen comes from breathing.

crafty that it convinces the brain that it’s real sugar, so the body releases insulin to help metabolize the artificial sugar. Since there is no real sugar present, the excess insulin, with nothing to do, performs its other evolutionary task, which is to signal the body to store fat. As well, there is firmly mounting evidence that aspartame is a significant neurotoxin. So my professional advice to you is this: If you have any synthetically sweetened foods in your home, step on them to ensure you kill them, then toss them out.

My advice is to give up stevia, aspartame, sucralose, sugar alcohols such as xylitol and malitol, and all of the other heavily used and marketed sweeteners unless you want to slow down your metabolism, gain weight, and become an addict.

Once she turned fifty, her metabolism slowed and she shed all inhibitions about portion control.

Eating more than you need is not necessarily a sign of a chemical imbalance or eating the wrong types of food. It is a sign that you are fundamentally out of balance.

Rapamycin works at a fundamental level of cell biology. In the early 1990s, scientists at Novartis’s predecessor, Sandoz, discovered that a rapamycin molecule inhibits a key cellular pathway regulating growth and metabolism. This pathway was eventually dubbed “target of rapamycin,” or TOR, and it’s found in everything from yeast to humans (it’s known as mTOR in mammals). MTOR is like the circuit breaker in a factory: When it’s activated, the cell grows and divides, consuming nutrients and producing proteins. When mTOR is turned down, the “factory” switches into more of a conservation mode, as the cell cleans house and recycles old proteins via a process called autophagy. One reason caloric restriction extends life span in animals, researchers believe, is because it slows down this mTOR pathway and cranks up autophagy. Rapamycin does the same thing, only without the gnawing hunger. “Really what rapamycin is doing is tapping into the body’s systems for dealing with reduced nutrition,” says Brian Kennedy, chief executive officer of the Buck Institute for Research on Aging in Novato, Calif. “We’ve evolved over billions of years to be really good at that. When things are good, we’re going to grow and make babies. And when things are not so good, we go into a more stress-resistant mode, so we survive until the next hunt. And it just so happens that stress resistance is good for aging.

Stress makes a person fat primarily because of an excessive secretion of the key stress hormone, cortisol, along with a reduced secretion of key anabolic hormones, such as DHEA, testosterone, and growth hormone. This combination of highly catabolic cortisol and reduced anabolic hormones causes the body to store fat, lose muscle, slow metabolic rate, and increase appetite—all of which have the ultimate effect of making a person fatter.

The stakeout. The least glamorous and yet often the most valuable activity in investigations. To endure the agonizing boredom and forestall restlessness, I slowed my metabolism into near rigor mortis until I was nothing more than a pair of eyeballs fixed

Cardamom, an ancient spice that you’ll find in Indian cooking, is often used as a digestive aid and a breath freshener. But it also stimulates the flow of bile, which enhances liver health and fat metabolism. Cinnamon contains phytochemicals that increase glucose metabolism in cells (and when glucose is metabolized, it doesn’t get stored as fat). It also can help to lower blood sugar, decrease blood pressure, and reduce triglyceride levels and “bad” (low-density lipoprotein [LDL]) cholesterol. Ginger helps control nausea, but it also decreases the stickiness of blood, which helps to prevent blood clots, and decreases inflammation. In animal studies, it lowered cholesterol and slowed the development of atherosclerosis. Turmeric contains curcumin, one of the most powerful compounds in the plant kingdom. Curcumin has been used at the University of Texas MD Anderson Cancer Center in cancer trials. It’s being studied in memory loss research at Columbia University Medical Center (it was shown to slow memory loss in laboratory animals) and at the University of California. It’s extremely healthy for the liver, which is “ground zero” for detoxification. Curcumin has also been shown to improve arthritis symptoms, not surprising in view of its enormous anti-inflammatory firepower. (Both of us take curcumin in supplement form; see more on supplements in Chapter 8.)

Another class of fats that warrant concern are polyunsaturated fatty acids, also known as PUFAs. Excessive intake of PUFAs, (found in industrial oils such as canola, corn, safflower, and soybean; margarine and buttery sprays and spreads; and assorted baked, frozen, packaged and processed foods) can also compromise health. These fats also oxidize easily and may contribute to systemic inflammation, as the immune system tries to deal with the oxidation. They may be a major factor in arterial oxidation and inflammation. Your endocrine system is especially sensitive to PUFA consumption, which can lead to symptoms such as a slowed metabolism, low energy levels, and sluggish thyroid function.

Alcohol consumption raises estrogen levels and—the bad news—slows down fat burning because your liver is busy processing alcohol instead of fat. Studies in postmenopausal women show that estrogen levels increase dramatically with each serving of alcohol you drink each day.

Alcohol poses a major problem for women with estrogen dominance. It slows down metabolism by more than 70 percent (temporarily—for about one day, which adds up if you drink daily), congests the liver, raises bad estrogens and cortisol, disrupts sleep (which raises cortisol even further), and gives you the crazy idea that eating more of the wrong foods is somehow a good idea

Each one visits a thousand flowers a day. They can dive at sixty miles an hour. They can fly backward. They can fly more than five hundred miles without pausing to rest. But when they rest they come close to death: on frigid nights, or when they are starving, they retreat into torpor, their metabolic rate slowing to a fifteenth of their normal sleep rate, their harts sludging nearly to a halt, barely beating, and if they are not soon warmed, if they do not soon find that which is sweet, their hearts grow cold and they cease to be.

Like rapamycin, metformin mimics aspects of calorie restriction. But instead of inhibiting TOR, it limits the metabolic reactions in mitochondria, slowing down the process by which our cellular powerhouses convert macronutrients into energy.20 The result is the activation of AMPK, an enzyme known for its ability to respond to low energy levels and restore the function of mitochondria. It also activates SIRT1, one of my lab’s favorite proteins. Among other beneficial effects, metformin inhibits cancer cell metabolism, increases mitochondrial activity, and removes misfolded proteins.21

The body’s metabolism slows down as people lose weight, which means they have to eat fewer and fewer calories to keep losing. But this study showed that, for the contestants who lost weight quickly, their metabolism kept slowing even when they started gaining weight again. Basically, however fat they had been, that’s what their bodies wanted them to be.

To expand on the above list, I think the most powerful strategy out there to avoid or treat cancer is to starve your cancer cells by depriving them of their only food source – sugar. Normal cells in your body can adapt to different energy sources, allowing them to use both carbs and fat for fuel. Cancer cells, on the other hand, do not express that metabolic flexibility and are only able to use sugar as an energy source. A man by the name of Dr. Otto Warburg was actually given the Nobel Prize in Physiology for this discovery over 75 years ago, and still virtually no oncologist actually uses this information! He discovered that cancer cells have a fundamentally different energy metabolism compared to healthy cells. He called his theory the “Warburg Effect,” which occurs in up to 80 percent of cancers.

Did you know that over 42 million children are suffering from metabolic disorders like Obesity & insulin resistance?

However, Agave nectar contains about 70–90% Fructose, and 10–30% Glucose. Given the harmful health effects of excess Fructose consumption, Agave Nectar may be even worse for your Metabolic health than regular Table sugar.

You need a little bit of fat—even the saturated kind—to maintain normal anabolic hormone levels. When you eat pure carbs and no fat, this can also aggravate blood sugar problems in those who are susceptible, develop into metabolic syndrome, and eventually lead to type 2 diabetes and cardiovascular disease. Eating healthy fat (and fiber) slows digestion, which helps control blood sugar and insulin more effectively. This makes fats especially important for people who are carb intolerant. Most surprising to many, eating nothing but nonfat, high-carb meals can sabotage your fat-loss goals by increasing hunger. After eating carbs without fiber or fat, your blood sugar peaks and quickly crashes, leaving you with that shaky, empty I-have-to-eat-now-or-I’m-going-to-pass-out feeling. It’s more than an emotional craving for a specific food; it’s physical hunger and it’s hard to resist. Cutting out all fat is not the answer. You need to eat fat.

No longer to accept anything at all, no longer to take anything, no longer to absorb anything—to cease reacting altogether. This fatalism…can preserve life under the most perilous conditions by reducing the metabolism, slowing it down, as a kind of will to hibernate.

Obesity is a hormonal dysregulation of fat mass. The body maintains a body set weight, much like a thermostat in a house. When the body set weight is set too high, obesity results. If our current weight is below our body set weight, our body, by stimulating hunger and/or decreasing metabolism, will try to gain weight to reach that body set weight. Thus, excessive eating and slowed metabolism are the result rather than the cause of obesity.

What you need,'' he said, ''is an ice-cream float.'' ''You and your ice-cream floats.'' ''They work, I tell you. It's very scientific. Cold things are good for nausea and —'' ''Your're always saying that, Charles, but I just don't think it's true.'' ''Would you just listen to me for a second? The ice cream slows down your digestion. The Coke settles your stomach and the caffeine cures your headache. Sugar gives you energy. And besides, it makes you metabolize the alcohol faster. It's the perfect food.

What you need,'' he said, ''is an ice-cream float.'' ''You and your ice-cream floats.'' ''They work, I tell you. It's very scientific. Cold things are good for nausea and —'' ''You're always saying that, Charles, but I just don't think it's true.'' ''Would you just listen to me for a second? The ice cream slows down your digestion. The Coke settles your stomach and the caffeine cures your headache. Sugar gives you energy. And besides, it makes you metabolize the alcohol faster. It's the perfect food.

The type of food you consume directly affects your metabolism and insulin response. Food is composed of three macronutrients: protein, carbohydrate, and fat, and each of these macronutrients affects your metabolism in a different way. One gram of protein or carbohydrate provides four calories, while one gram of fat contains nine calories. A calorie is the base unit of heat measurement related to metabolic rate. It measures how much energy a particular food provides to the body. Of course, if you do eat more calories than your body requires, it doesn’t matter whether those calories come from protein, carbohydrates, or fat—the extra fuel will be stored in the body as fat. Eating too few calories can be equally problematic. When you do not eat enough food, your body’s endocrine, immunological, and nervous systems begin to malfunction. The result is often hormonal imbalances, thyroid problems, and insulin resistance. When you are in a state of extreme caloric restriction, your body does everything possible to return to a state of homeostasis, or equilibrium—including slowing down your metabolic rate. A slow metabolism affects your energy levels, your digestive and hormonal health, and your ability to lose weight. In my case, severely restricting my calories increased my adrenal

our goal should be the opposite: to eat less, only as much as we need to maintain a slim and muscular weight, and no more, so as to keep our metabolic rate relatively slow.

According to the American College of Cardiology, fasting triggered a 1,300% increase in human growth hormone secretion in women, and an astounding 2,000% increase in men! This statistic alone is a definitive reason to drop what you’re doing and incorporate intermittent fasting into your lifestyle immediately. HGH, commonly known as your fitness hormone, plays a huge role in your health, fitness, and longevity. It actively promotes muscle growth, and even further boosts fat loss by increasing your metabolism. The fact that it simultaneously aids in muscle building and fat loss explains how HGH can help you get lean and lose weight without sacrificing your beneficial muscle mass you’ve worked so hard for.   The advantages of HGH go much further than muscle building and fat loss. It also works in the body to increase:

life span is determined by a fixed amount of metabolic activity: eat less, slow your metabolism, and you may live longer.

Measuring portions and trying to eat fewer calories, typically called “dieting,” almost never result in permanent weight loss and actually worsen the problem over time. Such “dieting” temporarily slows down your metabolic rate, so often more weight comes back than you lost. You wind up heavier than you were before you started dieting. This

Once the first chemotherapeutic agent was successfully administered to lymphoma patients across the country, a new era of oncology was ushered in. The context of its birth was heavy with metaphor. The world’s first chemotherapeutic agent was conceived from a substance designed to maim and break the will of enemies in a cloud of slow-moving death. Its therapeutic potential was discovered because of a terrible accident during some of humanity’s darkest years.

Some people's metabolism isn't just be slow, it may be in a comma

Some folks metabolism isn't just slow, it's in a comma.

Will I go into starvation mode? The short answer is an emphatic “no.” This is one of the great dieting myths—the fear that if you cut your calories for even a day, then your metabolic rate will slow right down as your body tries to conserve its fat stores. This starvation mode myth seems to be based on the Minnesota starvation experiment, a study carried out during World War II. In this experiment, young volunteers lived on extremely low calorie diets for up to six months.

In my thirties, I gained a sense of calm that came from professional stability and, although this is not backed by science, a general slowing of my metabolism, which is why I can gain seven pounds from eating one heavy dinner.

Metabolism slows down 90 percent after 30 minutes of sitting. The enzymes that move the bad fat from your arteries to your muscles, where it can get burned off, slow down. And after two hours, good cholesterol drops 20 percent. Just getting up for five minutes is going to get things going again. These things are so simple they’re almost stupid,” says Gavin Bradley1 in a 2015 interview with Brigid Schulte for the Washington Post.2 Bradley is one of the preeminent experts on the subject, and the director of an international organization dedicated to building awareness of how detrimental sitting all the time can be to our health.

It’s calorie-restriction diets that cause your metabolism to slow down to a crawl. Fasting does just the opposite. The hormone noradrenaline, which is produced during a period of fasting, boosts metabolic rates. As you fast more and regularly over time, metabolic rates go up, and more weight loss is achieved.

for good health, avoid the scary and intense blood-sugar roller coaster (peaks followed by crashes) and stick to the cute and gentle blood-sugar caterpillar ride (slow and steady ups and downs). Having a high glucose response to your meals is a risk factor for obesity, diabetes, cardiovascular disease, and other metabolic disorders, and it’s also a predictor of higher overall mortality.

AND SO WE have the vicious cycle of under-eating. We start by eating less and lose some weight. As a result, our metabolism slows and hunger increases. We start to regain weight. We double our efforts by eating even less. A bit more weight comes off, but again, total energy expenditure decreases and hunger increases. We start regaining weight. So we redouble our efforts by eating even less. This cycle continues until it is intolerable. We are cold, tired, hungry and obsessing about calories. Worst of all, the weight always comes back on. At some point, we go back to our old way of eating. Since metabolism has slowed so much, even resuming the old way of eating causes quick weight gain, up to and even a little past the original point. We are doing exactly what our hormones are influencing us to do.

In this more nuanced view, aging and the diseases that come with it are the result of multiple “hallmarks” of aging: • Genomic instability caused by DNA damage • Attrition of the protective chromosomal endcaps, the telomeres • Alterations to the epigenome that controls which genes are turned on and off • Loss of healthy protein maintenance, known as proteostasis • Deregulated nutrient sensing caused by metabolic changes • Mitochondrial dysfunction • Accumulation of senescent zombielike cells that inflame healthy cells • Exhaustion of stem cells • Altered intercellular communication and the production of inflammatory molecules Researchers began to cautiously agree: address these hallmarks, and you can slow down aging. Slow down aging, and you can forestall disease. Forestall disease, and you can push back death.

Blood vessels lose their elasticity, making the heart work harder to pump blood around the body Muscles, joints and tendons lose strength and flexibility Testosterone production plummets The metabolism slows down

The natural loss of muscle tissue that occurs with aging is accompanied by most people with an increase in levels of body fat. A person’s metabolism will naturally slow down as they age. This means that, even if they maintain the same caloric intake in their 50s as they did in their 30s, they burn fewer of them for energy and store more of them as body fat. In tandem with this is a general slowing down of activity as we age, meaning that we are burning off fewer calories.

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especially older adults.” As a coauthor of a 2017 paper by the International Society for Sports Nutrition, Dr. Lopez, along with contributors, stated that creatine not only enhances recovery, muscle mass, and strength in connection with exercise, but also protects against age-related muscle loss and various forms of brain injury.36 There’s even some evidence that creatine may boost our immune function and fat and carbohydrate metabolism. Generally well tolerated, creatine has a strong safety profile at a daily dose of three to five grams.37 7.

Even though we know that artificial sweeteners actually cause type 2 diabetes22 and weight gain, slow metabolism, increase hunger,23 and alter gut flora or bacteria to promote obesity and type 2 diabetes,24 they are still recommended by the ADA, diabetes doctors, and registered dietitians. That’s right. Artificial sweeteners make you fat and diabetic!

People often starve themselves in order to lose weight. That’s a no-go! The body is very resourceful, and it will slow down its metabolic rate in order to compensate for the lack of calories. It tries to hold onto every calorie you consume, since it is unsure when it will be fed again. Then, once you resume your normal caloric intake, your metabolic rate remains slowed down. This is why people who try restrictive diets usually gain their original weight back and often some more too. The good news is that if you want to lose weight, you should never be hungry. A well balanced diet consisting of small frequent meals (every 2.5 – 3.5 hours) is the key to long term success.

Our RMR decreases by about 5% every decade after thirty, mainly because of the loss of muscle mass associated with aging. Fortunately, our lean body mass can be controlled through proper nutrition and strength training. It only takes a few months of training to recover one or two decades of decrease in our RMR. Metabolically, muscle is very expensive tissue, even when it is at rest. Another way to positively influence our RMR is to provide our body with a steady flow of nutrients. The body is extremely resourceful, and during times of starvation it adapts by slowing down its RMR. It tries to save every calorie consumed by storing some as fat. Any of the common diets that severely restrict your caloric intake neglect this principal, and that is why people on those diets almost always gain at least their original weight back. When the body receives a regular flow of calories, in the form of frequent meals, it allows the RMR to remain high, and burn those very same calories off. Frequent meals also utilize the thermal effect of food. Eating temporarily cranks up your metabolism. The more meals you eat in a day, the more consistently your metabolism is boosted. You experience an increase in your RMR for about 5 hours every time you eat. This accounts for 5 – 10% of your total calorie expenditure. Over the long haul this can make quite a difference.

Blue is the color of the sky and the sea. It is often associated with depth and stability and symbolizes trust, loyalty, wisdom, confidence, intelligence, faith and truth. It is believed that blue has a beneficial effect on the mind and body: it slows metabolism and has a calming effect.

It’s true that low rep workouts, consisting of powerful and explosive movements, will build more size (but not less definition) than high rep workouts, because the “fast twitch” muscle fibers required in explosive movements are much larger than “slow twitch” fibers required for more enduring tasks. But really, for mass, wouldn’t you want to recruit all possible muscle fibers and not just the fast twitch? Likewise, for “definition”–that is, losing body fat so the striations in your muscles show more–wouldn’t you want to recruit all possible muscle fibers, especially since the number one factor affecting our resting metabolic rate, and thus fat loss, is muscle mass? The only thing you should alter depending on your goal–whether it’s to tone or bulk up–is nutrition.

the odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. To achieve longevity—to live longer and live better for longer—we must understand and confront these causes of slow death. Longevity has two components. The first is how long you live, your chronological lifespan, but the second and equally important part is how well you live—the quality of your years. This is called healthspan,

Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. To achieve longevity—to live longer and live better for longer—we must understand and confront these causes of slow death.

However, there is no time like your twenties to develop good habits for the rest of your life—it will only get harder as you get older when your metabolism slows and you have more responsibility at home and work. Strong nutrition and fitness habits will give you more energy, more focus, and more confidence.

The starting point is recognizing that selection has shaped powerful mechanisms to protect against starvation. During a famine, those mechanisms motivate animals to get food -any food- eat it quickly, and eat more than usual, because food supplies are obviously erratic. The system also adjusts the body weight set point upward because extra fat stores are valuable when food sources are unreliable. And, as noted already, weight loss slows down metabolism, which is appropriate when a person is starving but the opposite of what is needed when trying to lose weight. Also, intermittent access to food signals unreliable access to food supplies, so it increases food intake and bingeing, even in rats.

Even though all three diets had the same number of calories, the people on the low-GI and low-carbohydrate diet burned 125 to 325 calories more per day than did the people on the low-fat diet, and their blood vessels and metabolism were much healthier.118

Glucose and fructose are two kinds of sugars that contain equal amounts of calories (400 calories per 100 grams). Both are unhealthy in large amounts, but fructose even more so than glucose. Glucose can be processed by all organs in the body, whereas fructose is processed mainly in the liver. Consequently, fructose causes an even greater risk of fat accumulation in the liver, resulting in a potbelly, more fats in the blood, and insulin resistance. In addition, fructose creates cross-links with proteins much faster than glucose does. Fructose also sends fewer saturation hormones to the brain than does glucose, making you eat more of it and gain more weight. In short, although all these substances contain equal amounts of calories, they have completely different effects on your metabolism and your health, certainly in the long term.

As a result their metabolism produces many free radicals, in such large quantities that they can damage the cancer cells. Cancer cells actually profit greatly from antioxidants that wipe out the free radicals for them. That is why it might not be advisable to take antioxidants during treatment for cancer, as is sometimes suggested.

For one thing, as we see with the Hadza, daily energy expenditures are the same today in the industrialized world as they were in our hunter-gatherer past. Our bodies are incredibly adept at responding to changing activity levels to keep daily energy expenditures within a narrow window. But more crucially, blaming obesity on slow metabolism gets the cause and effect of weight change completely backward. Our metabolism doesn’t dictate energy balance, it responds to energy balance.

well cooked and eaten with a saturated fat. Remember: None of these foods should ever be consumed alone. You should always eat all vegetables and fruits with protein and fat to slow the blood sugar response. Even root vegetables, fruits, and fruit-vegetables eaten individually can throw your blood sugar out of whack.

Key Points As you age, your body naturally becomes less efficient. Changes you will go through include losing muscle mass, slowing of your metabolism, and producing less testosterone You have the power, through exercise, to slow down the aging process Exercise will improve your self - image and your self-confidence Regular exercise will make you physically and mentally stronger, improve your bone strength, body composition, coordination and balance Exercise will boost the efficiency of your heart and lungs and make you far less likely to succumb to age-related disease

This resistance to weight loss has been proven both scientifically and empirically.2 Obese persons that had lost weight required fewer calories because their metabolisms had slowed dramatically and desire to eat accelerates. The body actively resists long-term weight loss.

Metabolism slows down 90 percent after 30 minutes of sitting. The enzymes that move the bad fat from your arteries to your muscles, where it can get burned off, slow down. And after two hours, good cholesterol drops 20 percent. Just getting up for five minutes is going to get things going again.

The exercise intensity of 50 percent of VO2 max is an extremely interesting intensity from the physiological point of view. That’s when the stroke volume of the heart (the volume of blood pumped per one heartbeat) is the largest, lipid metabolism is the highest, and the accumulation of catecholamine (an indicator of lactate and sympathetic nerves’ agitation) starts.

A person suffering from the metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes.

Slow jogging not only prevents metabolic syndrome, but significantly increases the fitness level, thereby lowering mortality even in those already suffering from the syndrome.

Metabolic syndrome is not a specific disease itself, but the name for a group of risk factors (that tend to but do not have to occur together) that increase the risk of heart disease and other health problems, such as diabetes and stroke.

The list of oils with the highest concentration of PUFAs and that can be the most harmful are soybean oil, corn oil, safflower oil, grape seed oil, sesame seed, nut oils (peanut, walnut, almond, etc.), flaxseed, fish oil, cod liver oil, evening primrose, borage oils, and, yes, this even includes Omega-3 (EPA and DHA) and Omega-6, also known as the “essential fatty acids.

Starving yourself during the day and eating late at night slows down your metabolism, which leads to weight gain in many body types.

Place an ice pack on the back of the neck or upper trapezius area for 20–30 minutes, preferably in the evening, when insulin sensitivity is lowest. I place a towel on the couch while writing or watching a movie and simply lean back against the ice pack. 2. Consume, as Ray did, at least 500 milliliters of ice water on an empty stomach immediately upon waking. In at least two studies, this water consumption has been shown to increase resting metabolic rate 24–30%, peaking at 40–60 minutes post-consumption, though one study demonstrated a lower effect of 4.5%. Eat breakfast 20–30 minutes later à la the Slow-Carb Diet detailed in earlier chapters. 3. Take 5–10-minute cold showers before breakfast and/or before bed. Use hot water for 1–2 minutes over the entire body, then step out of water range and apply

the first day of fasting, the blood Sugar level drops below 70mg/dl. To restore the blood to the normal glucose level, liver glycogen is converted to glucose and released into the blood. This reserve is enough for a half day. The body then reduces the basal metabolic rate (BMR). The rate of internal chemical activity in resting tissue is lowered to conserve energy. The heart slows and blood pressure is reduced. Glycogen is pulled from the muscle causing some weakness. The first wave of cleansing is usually the worst.   Headaches,

We used it every winter, and in every time of drought or famine. We survived by getting depressed. Not clinically depressed, or Prozac depressed, but survival depressed, as in let’s slow down the metabolism, build up the fat stores, withdraw, turn inward, hibernate, cut everything back to bare minimum. Shut down and survive by letting all but the most critical systems atrophy and decay. In fact, all chronic stress works the same way.

While it may seem paradoxical, hunger also plays a key role in the development of obesity. “I often hear things like, ‘Those people can’t be hungry—they’re fat!’” says Janet Poppendieck, Ph.D., the author of Free for All: Fixing School Food in America. “But the least healthy, most obesity-inducing calories in our society are often the cheapest.” A study from the University of Washington found that junk food can cost an average of $ 1.76 per 1,000 calories, while more nutritious foods add up to $ 18.16 for the same amount. Food-insecure families may also be more prone to obesity because their bodies are essentially always in crash-diet mode, which ultimately slows down metabolism.

According to Dr. Lee, a healthy ratio would be somewhere between 50 and 100 times more progesterone to estrogen.