Pharmaceutical Companies In Quotes

The current ruling ontology denies any possibility of a social causation of mental illness. The chemico-biologization of mental illness is of course strictly commensurate with its depoliticization. Considering mental illness an individual chemico-biological problem has enormous benefits for capitalism. First, it reinforces Capital’s drive towards atomistic individualization (you are sick because of your brain chemistry). Second, it provides an enormously lucrative market in which multinational pharmaceutical companies can peddle their pharmaceuticals (we can cure you with our SSRIs). It goes without saying that all mental illnesses are neurologically instantiated, but this says nothing about their causation. If it is true, for instance, that depression is constituted by low serotonin levels, what still needs to be explained is why particular individuals have low levels of serotonin. This requires a social and political explanation; and the task of repoliticizing mental illness is an urgent one if the left wants to challenge capitalist realism.

Pharmaceutical companies raked in billions by forcing all kinds of pills down the throats of the ill-informed populace. So in light of these facts, his prank call could’ve been considered a wake-up call, as millions of people were swallowing their prescribed pills every day, relying on supposedly safe drugs to perpetually put off their mental issues instead of facing them head on and resolving them for good. Not only did these drugs that were labeled legal and effective mask issues, but they also made people’s mental issues worse.

Hope is beyond price and the pharmaceutical companies, which are run by businessmen not altruists, price their products accordingly.

I've been accustomed to mysteries, holy and otherwise, since I was a child. Some of us care for orphans, amass fortunes, raise protests or Nielsen ratings; some of us take communion or whiskey or poison. Some of us take lithium and antidepressants, and most everyone believes these pills are fundamentally wrong, a crutch, a sign of moral weakness, the surrender of art and individuality. Bullshit. Such thinking guarantees tradgedy for the bipolar. Without medicine, 20 percent of us, one in five, will commit suicide. Six-gun Russian roulette gives better odds. Denouncing these medicines makes as much sense as denouncing the immorality of motor oil. Without them, sooner or later the bipolar brain will go bang. I know plenty of potheads who sermonize against the pharmaceutical companies; I know plenty of born-again yoga instructors, plenty of missionaries who tell me I'm wrong about lithium. They don't have a clue.

Our primary health care should begin on the farm and in our hearts, and not in some laboratory of the biotech and pharmaceutical companies.

Repeat after me: pharma being shit does not mean magic beans cure cancer.

Pick a leader who will make their citizens proud. One who will stir the hearts of the people, so that the sons and daughters of a given nation strive to emulate their leader's greatness. Only then will a nation be truly great, when a leader inspires and produces citizens worthy of becoming future leaders, honorable decision makers and peacemakers. And in these times, a great leader must be extremely brave. Their leadership must be steered only by their conscience, not a bribe.

Pick a leader who will keep jobs in your country by offering companies incentives to hire only within their borders, not one who allows corporations to outsource jobs for cheaper labor when there is a national employment crisis. Choose a leader who will invest in building bridges, not walls. Books, not weapons. Morality, not corruption. Intellectualism and wisdom, not ignorance. Stability, not fear and terror. Peace, not chaos. Love, not hate. Convergence, not segregation. Tolerance, not discrimination. Fairness, not hypocrisy. Substance, not superficiality. Character, not immaturity. Transparency, not secrecy. Justice, not lawlessness. Environmental improvement and preservation, not destruction. Truth, not lies.

A NATION'S GREATNESS DEPENDS ON ITS LEADER To vastly improve your country and truly make it great again, start by choosing a better leader. Do not let the media or the establishment make you pick from the people they choose, but instead choose from those they do not pick. Pick a leader from among the people who is heart-driven, one who identifies with the common man on the street and understands what the country needs on every level. Do not pick a leader who is only money-driven and does not understand or identify with the common man, but only what corporations need on every level. Pick a peacemaker. One who unites, not divides. A cultured leader who supports the arts and true freedom of speech, not censorship. Pick a leader who will not only bail out banks and airlines, but also families from losing their homes -- or jobs due to their companies moving to other countries. Pick a leader who will fund schools, not limit spending on education and allow libraries to close. Pick a leader who chooses diplomacy over war. An honest broker in foreign relations. A leader with integrity, one who says what they mean, keeps their word and does not lie to their people. Pick a leader who is strong and confident, yet humble. Intelligent, but not sly. A leader who encourages diversity, not racism. One who understands the needs of the farmer, the teacher, the doctor, and the environmentalist -- not only the banker, the oil tycoon, the weapons developer, or the insurance and pharmaceutical lobbyist. Pick a leader who will keep jobs in your country by offering companies incentives to hire only within their borders, not one who allows corporations to outsource jobs for cheaper labor when there is a national employment crisis. Choose a leader who will invest in building bridges, not walls. Books, not weapons. Morality, not corruption. Intellectualism and wisdom, not ignorance. Stability, not fear and terror. Peace, not chaos. Love, not hate. Convergence, not segregation. Tolerance, not discrimination. Fairness, not hypocrisy. Substance, not superficiality. Character, not immaturity. Transparency, not secrecy. Justice, not lawlessness. Environmental improvement and preservation, not destruction. Truth, not lies. Most importantly, a great leader must serve the best interests of the people first, not those of multinational corporations. Human life should never be sacrificed for monetary profit. There are no exceptions. In addition, a leader should always be open to criticism, not silencing dissent. Any leader who does not tolerate criticism from the public is afraid of their dirty hands to be revealed under heavy light. And such a leader is dangerous, because they only feel secure in the darkness. Only a leader who is free from corruption welcomes scrutiny; for scrutiny allows a good leader to be an even greater leader. And lastly, pick a leader who will make their citizens proud. One who will stir the hearts of the people, so that the sons and daughters of a given nation strive to emulate their leader's greatness. Only then will a nation be truly great, when a leader inspires and produces citizens worthy of becoming future leaders, honorable decision makers and peacemakers. And in these times, a great leader must be extremely brave. Their leadership must be steered only by their conscience, not a bribe.

Intense advertisement by pharmaceutical companies are making doctors look useless

Intense advertisement by pharmaceutical companies is making doctors look useless

Big Pharma needs sick people to prosper. Patients, not healthy people, are their customers. If everybody was cured of a particular illness or disease, pharmaceutical companies would lose 100% of their profits on the products they sell for that ailment. What all this means is because modern medicine is so heavily intertwined with the financial profits culture, it’s a sickness industry more than it is a health industry.

Had Prozac been available last century, Baudelaire's "spleen," Edgar Allan Poe's moods, the poetry of Sylvia Plath, the lamentations of so many other poets, everything with a soul would have been silenced*.... If large pharmaceutical companies were able to eliminate the seasons, they would probably do so--for profit, of course. *This does not mean that Sylvia Plath should not have been medicated at all. The point is that pathologies should be medicated when there is risk of suicide, not mood swings.

Suicide rates have not slumped under the onslaught of antidepressants, mood-stabilizers, anxiolytic and anti-psychotic drugs; the jump in suicide rates suggests that the opposite is true. In some cases, suicide risk skyrockets once treatment begins (the patient may feel not only penalized for a justifiable reaction, but permanently stigmatized as malfunctioning). Studies show that self-loathing sharply decreases only in the course of cognitive-behavioral treatment.

Pick a leader who will not only bail out banks and airlines, but also families from losing their homes -- or jobs due to their companies moving to other countries. Pick a leader who will fund schools, not limit spending on education and allow libraries to close. Pick a leader who chooses diplomacy over war. An honest broker in foreign relations. A leader with integrity, one who says what they mean, keeps their word and does not lie to their people. Pick a leader who is strong and confident, yet humble. Intelligent, but not sly. A leader who encourages diversity, not racism. One who understands the needs of the farmer, the teacher, the doctor, and the environmentalist -- not only the banker, the oil tycoon, the weapons developer, or the insurance and pharmaceutical lobbyist.

Wake up America! The insurance companies took over health care! Wake up America! The pharmaceutical companies took over drug pricing! Wake up America! The speculators took over Wall Street! Wake up America! They want your Social Security! Wake up America! Multinational corporations took over our trade policies! Wake up America! We went into Iraq for oil! WAKE UP AMERICA!

Oil companies start every war around the world, insurance companies, the medical field, pharmaceutical companies are partners in crime. Financial institution collect all that the little man earned in the past 10 years and the AI will end humanity once and for all

It's a fucking pharmaceutical conspiracy, Eve. We've wiped out just about every known plague, disease, and infection. Oh, we come up with a new one every now and again, to give the researchers something to do. But none of these bright-eyed medical types, none of the medi-computers can figure out how to cure the common fucking cold. You know why?" Even couldn't stop the smile. She waited patiently until Mavis finished another bout of explosive sneezing. "Why?" "Because the pharmaceutical companies need to sell drugs. You know what a damn sinus tab costs? You can get anticancer injections cheaper. I swear it.

The public does not ask the simple question: if vaccines are as safe as sugar water, why do the pharmaceutical companies need complete financial immunity and be protected by a battalion of lawyers from the US Department of Justice?

It is clear from the evidence presented in this book that the pharmaceutical industry does a biased job of disseminating evidence - to be surprised by this would be absurd - whether it is through advertising, drug reps, ghostwriting, hiding data, bribing people, or running educational programmes for doctors.

Fauci generation”—children born after his elevation to NIAID kingpin in 1984— the sickest generation in American history, and has made Americans among the least healthy citizens on the planet. His obsequious subservience to the Big Ag, Big Food, and pharmaceutical companies has left our children drowning in a toxic soup of pesticide residues, corn syrup, and processed foods, while also serving as pincushions for 69 mandated vaccine doses by age 18—none of them properly safety tested.55

As James Surowiecki noted in a New Yorker article, given a choice between developing antibiotics that people will take every day for two weeks and antidepressants that people will take every day for ever, drug companies not surprisingly opt for the latter. Although a few antibiotics have been toughened up a bit, the pharmaceutical industry hasn’t given us an entirely new antibiotic since the 1970s.

No,” said a third student. “Novartis is a public company. It’s not the boss or the board who decides. It’s the shareholders. If the board changes its priorities the shareholders will just elect a new board.” “That’s right,” I said. “It’s the shareholders who want this company to spend their money on researching rich people’s illnesses. That’s how they get a good return on their shares.” So there’s nothing wrong with the employees, the boss, or the board, then. “Now, the question is”—I looked at the student who had first suggested the face punching—“who owns the shares in these big pharmaceutical companies?” “Well, it’s the rich.” He shrugged. “No. It’s actually interesting because pharmaceutical shares are very stable. When the stock market goes up and down, or oil prices go up and down, pharma shares keep giving a pretty steady return. Many other kinds of companies’ shares follow the economy—they do better or worse as people go on spending sprees or cut back—but the cancer patients always need treatment. So who owns the shares in these stable companies?” My young audience looked back at me, their faces like one big question mark. “It’s retirement funds.” Silence. “So maybe I don’t have to do any punching, because I will not meet the shareholders. But you will. This weekend, go visit your grandma and punch her in the face. If you feel you need someone to blame and punish, it’s the seniors and their greedy need for stable stocks.

Some have estimated that the pharmaceutical industry overall spends about twice as much on marketing and promotion as it does on research and development.

I don’t understand. Half the population in the world goes through this every month. If a pharmaceutical company were to develop an effective pill specifically for menstrual cramps, not the ‘pain medication’ that makes you sick, they would make a fortune.

Gene patents are the point of greatest concern in the debate over ownership of human biological materials, and how that ownership might interfere with science. As of 2005—the most recent year figures were available—the U.S. government had issued patents relating to the use of about 20 percent of known human genes, including genes for Alzheimer’s, asthma, colon cancer, and, most famously, breast cancer. This means pharmaceutical companies, scientists, and universities control what research can be done on those genes, and how much resulting therapies and diagnostic tests will cost. And some enforce their patents aggressively: Myriad Genetics, which holds the patents on the BRCA1 and BRCA2 genes responsible for most cases of hereditary breast and ovarian cancer, charges $3,000 to test for the genes. Myriad has been accused of creating a monopoly, since no one else can offer the test, and researchers can’t develop cheaper tests or new therapies without getting permission from Myriad and paying steep licensing fees. Scientists who’ve gone ahead with research involving the breast-cancer genes without Myriad’s permission have found themselves on the receiving end of cease-and-desist letters and threats of litigation.

Anyone who is truly crazy, in my book, wouldn't be able to understand the dialectic of crazy and not-crazy. Listen, I've worked for the pharmaceutical companies, they have a vested belief in making you believe that if you have a chemical imbalance you need them to be 'cured' of your current issues and personality. Indefinitely. Imagine diagnosing personality only in terms of its negative aspects. Does this strike you as a strategy designed for health? The only way to deal with a problem is to fucking deal with it. Get inside what positive motivation, what intention, makes you behave in the way you are... and how you could maybe satisfy that need in a healthier or at least more agreeable manner. America wants quick, easy and painless; being a real person is slow, difficult and very messy.

EIGHTH AMENDMENT The government shall not “crack down” on drug crime while taking kickbacks from industries and companies perpetuating addiction and abuse. You can’t fight wars on drugs—only on people. The drug war kills people, not drugs. Anytime you hear a politician talk about being tough on drugs but then say nothing about pharmaceutical companies, doctors, or insurance providers needing reform as well, you call them what they are: hacks. And hit them in the fa—we mean, vote against them.

The father of Ruth van Cleve's child, she reports, is under the protection and care of the Norfolk County Correctional Authority, awaiting sentencing for what Ruth van Cleve describes several times as operating a pharmaceutical company without a license.

So, if we're to make any sense of the mess that the pharmaceutical industry - and my profession - has made of the academic literature, then we need an amnesty: we need a full and clear declaration of all the distortions, on missing data, ghostwriting, and all the other activity described in this book, to prevent the ongoing harm that they still cause.

Can the CEO of a pharmaceutical company prioritize opioid addiction as a top concern if they are making a profit from opioids?

The truth of the matter is that the light at the end of the tunnel generally belongs to the pharmaceutical companies.

In Western countries, for instance, it is legal for physicians to receive “bribes” in the form of cash by pharmaceutical companies for every new patient they put on their drugs.

It’s not entirely clear why we have sinuses, aside from their role in providing a huge revenue stream for pharmaceutical companies and over-the-counter drug makers.

Curiosity keeps us happier, healthier, and more fulfilled. If curiosity were a pill, all the world’s pharmaceutical companies would call it a super-drug and clamor to sell it.

Giselle Chapman was hired by Bristol-Myers Squibb, one of the leading pharmaceutical companies at that time. She became their number one sales representative, and went on to form her own consulting company.

Here we will see that pharmaceutical companies spend tens of billions of pounds every year trying to change the treatment decisions of doctors: in fact, they spend twice as much on marketing and advertising as they do on the research and development of new drugs. Since we all want doctors to prescribe medicine based on evidence, and evidence is universal, there is only one possible reason for such huge spends: to distort evidence-based practice.

income inequality” was actually the issue, why is there such outrage at the oil and pharmaceutical company executives who at least keep us warm at night and heal our sick as they take our money, but not a protester to be found questioning the career politicians who produce nothing and yet have somehow become multimillionaires just about all?

The Sussexes were cheered for urging manufacturers to donate free vaccines to poor countries. ‘The ultra-wealthy pharmaceutical companies are not sharing the recipes to make them,’ Harry told the crowd. ‘Recipes’ is the word he used.

The pharmaceutical companies that fund med schools don’t want this fact realized, and therefore the information is suppressed. Many pharmaceutical companies and doctors make money by treating symptoms rather than causations. When causations are understood, cures are oftentimes a given. Cures don’t make money. Why was Aspartame released into the population despite evidence of the damage it causes while Donald Rumsfeld was CEO of Searle? Why do you think George Bush was on the board of directors for Eli Lilly9 drug manufacturing? To counteract the mass genocide he perpetuates? Why do you think politicians are so healthy and live so long? What do they know that they aren’t telling us? I’m not saying this is all a conspiracy to thin the population, but pertinent health information should be public knowledge rather than deliberately suppressed. If this information were taught in schools, unethical drug companies would loose their control on the world.

At this time we should take a brife moment to mention quacks: alternative therapists who sell vitamins and homeopathy sugar pills [the latter of which, by definition, contain no active ingredients], which perform no better than placebo in fair tests, and who use even cruder marketing tricks than the ones described in this book. In these people profit at all from the justified anger that people feel towards the pharmaceutical industry, then it comes at the expense of genuinely constructive activity. Selling ineffective sugar pills is not a meaningful policy response to the regulatory failure we have seen in this book

the Times says there's a heroin epidemic, Malone thinks, which is only an epidemic of course because now white people are dying. Whites started to get opium-based pills from their physicians: oxycodone, vicodin... But, it was expensive and doctors were reluctant to prescribe too much for exactly the fear of addiction. So the white folks went to the open market and the pills became a street drug. It was all very nice and civilized until the Sinoloa cartel down in Mexico made a corporate decision that it could undersell the big American pharmaceutical companies by raising production of its heroin thereby reducing price. As an incentive, they also increased its potency. The addicted white Americans found that Mexican ... heroin was cheaper and stronger than the pills, and started shooting it into their veins and overdosing. Malone literally saw it happening. He and his team busted more bridge-and-tunnel junkies, suburban housewives and upper Eastside madonnas than they could count....

Thus, if any FDA-approved drug like hydroxychloroquine (or ivermectin) proved effective against COVID, pharmaceutical companies would no longer be legally allowed to fast-track their billion-dollar vaccines to market under Emergency Use Authorization.

And in the case of fecal transplants, there’s no drug or medical device involved, and thus no pharmaceutical company or device maker with diverticula deep enough to fund the multiple rounds of controlled clinical trials. If anything, drug companies might be inclined to fight the procedure’s approval. Pharmaceutical companies make money by treating diseases, not by curing them. “There’s billions of dollars at stake,” says Khoruts. “I told Katerina, if this works, don’t be surprised to find me at the bottom of the river.

Democratic, and most Republican, health-care plans don’t call for expropriating the private property of doctors and pharmaceutical companies or even for the cessation of employer-provided health care. Rather, they want to use corporations for government by proxy.

Key fact: in 2003 pharmaceutical companies spent more on marketing and sales than they did on research and development. When it comes time to invest, it’s pretty clear that spreading the ideas behind the medicine is more important than inventing the medicine itself.

If tomorrow morning by some stroke of magic every dazed and benighted soul woke up with the power to take the first step toward pursuing his or her dreams, every shrink in the directory would be out of business. Prisons would stand empty. The alcohol and tobacco industries would collapse, along with the junk food, cosmetic surgery, and infotainment businesses, not to mention pharmaceutical companies, hospitals, and the medical profession from top to bottom. Domestic abuse would become extinct, as would addiction, obesity, migraine headaches, road rage, and dandruff.

Women can get depressed before their period, but PMS is not just depression. Yet PMS is often considered by medical doctors and pharmaceutical companies to be a psychiatric condition suitable for treatment with selective serotonin reuptake inhibitors such as fluoxetine (Prozac, Serafem). But

The oligarchy was divided into Liberals and Conservatives, who were united in their terror of communism after the success of the Cuban Revolution, especially since many of them had had interests in the brothels and casinos of Havana; others had had interests in pharmaceutical companies that manufactured drugs to cure the diseases spread by the former, and some in supplying guns to be used by gangs struggling for control of the latter. However, the Liberals and Conservatives differed over how to combat the spread of such appalling beliefs as “equality,” “fair pay,” and “democracy.” The Conservatives believed in coming down hard on them; this involved being curt with your campesinos, keeping them illiterate, and paying them a fixed wage of 150 pesos a week. The Liberals, on the other hand, believed in being jolly with your campesinos, teaching them to read bits of paper with instructions on them, and paying them a fixed wage of 150 pesos a week. In this way they hoped that the peasants would become too contented to bother to be Communists. The whole situation became infinitely confused by the Conservatives’ habit of describing the Liberals as “Communists.

The pharmaceutical drug industry is a half-trillion dollar per year global industry, with almost 300 billion dollars in the United States alone. The pharmaceutical companies and their shareholders rely on people to be sick, or else their stocks will plummet. There is no money to be made in health.

The real danger is found in Humanity’s refusal to move beyond the trap of instinct and into the intellectual mind. The refusal to accept our health and the health of every other living thing on this planet must always come before profit. Whether it’s the oil companies, pharmaceutical companies; or anyone else; we are not Gods no matter how much the New Agers like to proclaim it. In that path lies the rubble of the enemy of life, his Fallen God Bombers and his murderous dark medics. Out of that emanates the force of fear; fear of judgement, fear of difference and fear the other will bring you pain.

Csikszentmihalyi teamed up with two other leading psychologists—Howard Gardner at Harvard, and William Damon at Stanford—to study these changes, and to see why some professions seemed healthy while others were growing sick. Picking the fields of genetics and journalism as case studies, they conducted dozens of interviews with people in each field. Their conclusion32 is as profound as it is simple: It’s a matter of alignment. When doing good (doing high-quality work that produces something of use to others) matches up with doing well (achieving wealth and professional advancement), a field is healthy. Genetics, for example, is a healthy field because all parties involved respect and reward the very best science. Even though pharmaceutical companies and market forces were beginning to inject vast amounts of money into university research labs in the 1990s, the scientists whom Csikszentmihalyi, Gardner, and Damon interviewed did not believe they were being asked to lower their standards, cheat, lie, or sell their souls. Geneticists believed that their field was in a golden age in which excellent work brought great benefits to the general public, the pharmaceutical companies, the universities, and the scientists themselves.

Hammond shook his head sadly. “Yet, you’ll remember,” he said, “the original genetic engineering companies, like Genentech and Cetus, were all started to make pharmaceuticals. New drugs for mankind. Noble, noble purpose. Unfortunately, drugs face all kinds of barriers. FDA testing alone takes five to eight years—if you’re lucky. Even worse, there are forces at work in the marketplace. Suppose you make a miracle drug for cancer or heart disease—as Genentech did. Suppose you now want to charge a thousand dollars or two thousand dollars a dose. You might imagine that is your privilege. After all, you invented the drug, you paid to develop and test it; you should be able to charge whatever you wish. But do you really think that the government will let you do that? No, Henry, they will not. Sick people aren’t going to pay a thousand dollars a dose for needed medication—they won’t be grateful, they’ll be outraged. Blue Cross isn’t going to pay it. They’ll scream highway robbery. So something will happen. Your patent application will be denied. Your permits will be delayed. Something will force you to see reason—and to sell your drug at a lower cost. From a business standpoint, that makes helping mankind a very risky business. Personally, I would never help mankind.

The trillion-dollar pharmaceutical industry puts its research money into the search for magic bullets in the form of chemicals because pills mean money. If energy healing could be made into tablet form, drug manufacturers would get interested quickly. Instead, they identify deviations in physiology and behavior that vary from some hypothetical norm as unique disorders or dysfunctions, and then they educate the public about the dangers of these menacing disorders. Of course, the over-simplified symptomology used in defining the dysfunctions prevalent in drug company advertisements has viewers convinced they are afflicted by that particular malady. “Do you worry? Worry is a primary symptom of ‘medical condition’ called anxiety disorder. Stop your worry. Tell your doctor you want Addictazac, the new passion-pink drug.

The pharmaceutical companies were going to use Theranos’s blood-testing system to monitor patients’ response to new drugs. The cartridges and readers would be placed in patients’ homes during clinical trials. Patients would prick their fingers several times a day and the readers would beam their blood-test results to the trial’s sponsor.

Somewhere in the secret recesses of Pfizer, or GlaxoSmithKline, or one of the big pharmaceutical companies, I imagine there's a high security dungeon where three hunchbacked witches stir a massive industrial cauldron of crap I don't want to know about, but I must ingest on a daily basis. And the generic versions aren't even brewed by real witches.

In the mid-1980s, the medical world wrestled with how to use the new opiates that pharmaceutical companies were developing to treat pain. David Procter was an early and aggressive adopter. He prescribed opiates for neck, leg, and lower back pain, arthritis, and lower lumbar spine pain. He combined them with benzodiazepines—anxiety relievers, of which Valium and Xanax, Procter’s favorite, are the best known. In Portsmouth, people had anxiety and they had pain. Appalachia had a long history of using benzodiazepines—dating to the release of Valium in the early 1960s. Little old ladies used it. In this part of the country, anything that relieved pain was welcome. But opiates and benzos together also led quickly to addiction.

When a pharmaceutical company releases a new drug, they have a big launch meeting, which can seem like some unholy combination of a bachelor party, a marketing convention, and a revival meeting.

We now know that early stress and adversity can literally get under a child’s skin, where it can cause damage that lasts a lifetime. But there is also some positive news in this research. It turns out that there is a particularly effective antidote to the ill effects of early stress, and it comes not from pharmaceutical companies or early-childhood educators but from parents. Parents and other caregivers who are able to form close, nurturing relationships with their children can foster resilience in them that protects them from many of the worst effects of a harsh early environment. This message can sound a bit warm and fuzzy, but it is rooted in cold, hard science. The effect of good parenting is not just emotional or psychological, the neuroscientists say; it is biochemical.

Melancholy (1) An excess of black bile, anatomized by Robert Burton, embraced by the swooning Romantics as evidence of their fine sensibilities, now fallen into disrepair, renamed as depression, wrongly attributed to a deficiency of serotonin and cured by infantilizing, self-indulgent 'therapy' and overpriced, addictive drugs pushed on harassed, gullible doctors by unscrupulous pharmaceutical companies which suppress their terrible side-effects in order to pursue their profits. (2) A crippling disease of unknown aetiology which throughout human history has devoured hope, destroyed lives and, after a period of living death, sometimes relaxed its grip just long enough for the sufferer to summon the energy for a merciful suicide; now, at last, frequently curable by a combination of therapy and antidepressants.

If you don’t fit into the ideal box of normal or what’s acceptably different, then you’re just another patient of missed diagnoses that fill the pockets of every multi-million dollar pharmaceutical company.

Over the last fifty years at NIH, Dr. Fauci has played a leading role in Big Pharma’s engineered demolition of American health and democracy, working hand in glove with pharmaceutical companies to overcome federal regulatory obstacles and transform the NIH and NIAID into a single-minded vehicle for development, promotion, and marketing of patented pharmaceutical products, including vaccines and vaccine-like products.

[Free trade agreements] are trade agreements that don't stick to trade…they colonize environmental labor, and consumer issues of grave concern (in terms of health safety, and livelihoods too) to many, many hundreds of millions of people - and they do that by subordinating consumer, environmental, and labor issues to the imperatives and the supremacy of international commerce. That is exactly the reverse of how democratic societies have progressed, because over the decades they've progressed by subordinating the profiteering priorities of companies to, say, higher environmental health standards; abolition of child labor; the right of workers to have fair worker standards…and it's this subordination of these three major categories that affect people's lives, labor, environment, the consumer, to the supremacy and domination of trade; where instead of trade getting on its knees and showing that it doesn't harm consumers - it doesn't deprive the important pharmaceuticals because of drug company monopolies, it doesn't damage the air and water and soil and food (environmentally), and it doesn't lacerate the rights of workers - no, it's just the opposite: it's workers and consumers and environments that have to kneel before this giant pedestal of commercial trade and prove that they are not, in a whole variety of ways, impeding international commerce…so this is the road to dictatorial devolution of democratic societies: because these trade agreements have the force of law, they've got enforcement teeth, and they bypass national courts, national regulatory agencies, in ways that really reflect a massive, silent, mega-corporate coup d'etat…that was pulled off in the mid-1990's.

When I interviewed with the Chief of Family Medicine at a large medical corporation on the West Coast, he explained that, since he was part of a team of people who arranged for pharmaceutical companies to issue cash grants, he was in a position to offer me a particularly enticing salary. “What are the grants for?” I asked. “We have a quality improvement program that tracks physician prescribing patterns. We call it ‘quality’ but it’s really about money.” And that’s all it’s about. It works like this. In his organization, any patient with LDL cholesterol over 100 is put on a cholesterol-lowering medication. Any person with a blood pressure higher than 140/90 is put on a blood pressure medication. Any person with “low bone density” is put on a bone-remodeling inhibitor. And so on. The doctors who prescribe the most get big bonuses. Those who prescribe the least get fired. With a hint of incredulousness in his voice, he explained, “So far, every time we’ve asked for funding for our program, the drug companies give it to us.” If this is where healthcare is headed, then these hybrid physicians-executives will instinctively turn their gaze to our children and invent more creative methods to bulldoze an entire generation into the bottomless pit of chronic disease.

Today, Coca-Cola still actually contains coca extract, just without the fun part. Although the exact recipe is a closely guarded trade secret, the company does import coca leaves legally from Peru’s National Coca Company. After the cocaine is extracted and sold for pharmaceutical use by eye, ear, nose, and throat specialists as a topical anesthesia, the remaining flavor of the coca leaves is enveloped into the secret recipe.

The Oregonian published an exposé by reporter Steve Suo that reveals that the government could have contained (and could still contain) the meth epidemic. Only nine factories manufacture the bulk of the world’s supply of ephedrine and pseudoephedrine, but pharmaceutical companies—and legislators influenced by them—have stopped every move that would have effectively controlled the distribution of the chemicals so they could not be diverted to meth superlabs.

It is unfortunate that in some places, especially in the United States, people have resisted making choices that will keep them and their families safer. I don’t agree with these choices, but I also think it’s unhelpful to simply label them “anti-science,” as so many people do. In her book On Immunity, Eula Biss looks at vaccine hesitancy in a way that I think also helps explain the resentment we’re seeing toward other public health measures. The distrust of science is just one factor, she says, and it is compounded by other things that trigger fear and suspicion: pharmaceutical companies, big government, elites, the medical establishment, male authority. For some people, invisible benefits that might materialize in the future are not enough to get them past the worry that someone is trying to pull the wool over their eyes. The problem is even worse in periods of severe political polarization, such as the one we’re in now.

My contribution is that if the pharmaceutical companies with the help of our federal government, legislative and judicial branches has “locked up”, "bound", placed under martial law, our rights and freedoms to not be experimented on, to suffer treatment of unsafe medical practices and then also limit the freedom for independent thinkers and scientific research into examining the events around health disease, vaccines and medicine, then how are we going to become unbound, freed from the medically tyrant? Is it already too late?

The very Internet companies that snookered us all with the promise of democratizing communications made it impermissible for Americans to criticize their government or question the safety of pharmaceutical products; these companies propped up all official pronouncements while scrubbing all dissent. The same Tech/Data and Telecom robber barons, gorging themselves on the corpses of our obliterated middle class, rapidly transformed America’s once-proud democracy into a censorship and surveillance police state from which they profit at every turn.

Like Galileo’s colleagues, the “Lockdown Left” has abandoned the discipline of evidence-based medicine. Instead of scientific citation, they rely on appeals to often undeserving authorities who have manufactured “scientific consensus” by cherry-picking data to support a predetermined policy. Sanctimonious bromides to “follow the science,” “trust the experts,” most often mean blind dogmatic trust in the official—and often whimsical—pronouncements of amoral pharmaceutical companies and their venal government vassals at captive agencies like CDC, FDA, NIH, and WHO.

Over the last 30 odd years, Democrats have moved to the right and the right has moved into the mental hospital. So what we have is one perfectly good party for hedge fund managers, credit card companies, banks, defense contractors, big agriculture and the pharmaceutical lobby... That's the Democrats. And they sit across the aisle from a small group of religious lunatics, flat-earthers and civil war re-enactors who mostly communicate by AM radio and call themselves the Republicans and who actually worry that Obama is a socialist. Socialist? He's not even a liberal.

The 1950s witnessed especially rapid expansion of electronic and electrical firms, of tobacco, soft drink, and food-processing companies, and of the chemical, plastics, and pharmaceutical industries. IBM blossomed as a leader in the computer business, soon to become a guiding star of the American economy.

Good luck with that, Harvath thought. In his experience, life was predominantly made up of three distinct groups: sheep, sheepdogs, and wolves. And if there was one thing he had learned from a lifetime of hunting wolves and protecting sheep, it was that sheep had two speeds—graze and stampede. Now that word was out that the virus was loose, all bets were off. Very soon, chaos was going to ensue. “What else do you have?” he asked, bracing himself for more bad news. “The pharmaceutical companies Damien’s involved with appear pretty benign. One focuses on dementia medication and the other on birth control drugs.

Commander, I believe we share a belief that the country is at a crossroads.” “You sound more optimistic than I am.” “That’s the political way of saying ‘I don’t know if we can save it.’ The lobbyists, big tech, the defense industry, pharmaceutical companies—they have real power, real control. The people, as you correctly noted, get manipulated and taxed, with no recourse other than to vote, but that vote means less and less the more power and control these corporations accumulate.” “It’s a machine,” Reece said. “I don’t want any part of it.” “There is no New World, Commander. No faraway lands in which to plant a flag and start over.

It’s a demonic feedback loop. Let me see if I can get this straight. Pharmaceutical companies sell mountains of drugs to factory farms, which depend on them to maintain their abnormally intensive systems. The animals develop antibiotic resistance that spreads to humans. Humans need stronger drugs. In the meantime, the animal industries flood the government with cash in exchange for subsidies. The government, invested in keeping the generous animal food lobbies flush, runs federal programs pushing people to eat increasing amounts of animal-based foods. People oblige. People get sick, requiring medication for the rest of their lives, along with expensive medical procedures. The drugs and procedures falsely assure them that they can continue to eat the food that made them sick in the first place. People continue to support the animal agriculture industry by buying their products, which pay for studies to further convince the public that animal products are an essential part of a healthy diet. People continue to support the pharmaceutical companies because they are tethered to their prescription drugs. This allows drug companies to pay for the “education” of our doctors who prescribe more drugs to us. Then pharmaceutical companies sell mountains of drugs to factory farms…

Very few people are aware that infections from resistant bacteria, often picked up in hospitals during routine procedures, are the third leading cause of death in the U.S. (In 1999 they were fourth.) Very few people know, as well, that the world’s leading pharmaceutical companies have stopped research and development on new antibiotics—there are virtually no new ones in the pipeline. Within the next few decades, we face, as many bacterial researchers have pointed out, the emergence of untreatable epidemic diseases more deadly than any known in history. Or as David Livermore, one of Britain’s primary bacterial resistance researchers, puts it . . . It is naive to think we can win.

What the Soviet émigrés brought with them is symptomatic of what Israeli venture capitalist Erel Margalit believes can be found in a number of dynamic economies. “Ask yourself, why is it happening here?” he said of the Israeli tech boom. We were sitting in a trendy Jerusalem restaurant he owns, next to a complex he built that houses his venture fund and a stable of start-ups. “Why is it happening on the East Coast or the West Coast of the United States? A lot of it has to do with immigrant societies. In France, if you are from a very established family, and you work in an established pharmaceutical company, for example, and you have a big office and perks and a secretary and all that, would you get up and leave and risk everything to create something new? You wouldn’t. You’re too comfortable. But if you’re an immigrant in a new place, and you’re poor,” Margalit continued, “or you were once rich and your family was stripped of its wealth—then you have drive. You don’t see what you’ve got to lose; you see what you could win. That’s the attitude we have here—across the entire population.

They write the steady stream of editorials that appear in local and national newspapers to reinforce the hackneyed orthodoxies of the pharmaceutical paradigms—“all vaccines are safe and effective,” etc. They root out heresy by sitting on the state medical boards—the “Inquisition” courts—that censure and de-license dissident doctors. They control the medical journals and peer-review journal literature to fortify Pharma’s agenda. They teach on medical school faculties, populate journal editorial boards, and chair university departments. They supervise hospitals and chair hospital departments. They act as expert witnesses for pharmaceutical companies in civil court and the federal vaccine court. They present awards to one another.

This new marketplace for drugs proved profitable for all involved. Drug industry revenues topped $1 billion in 1957, the pharmaceutical companies enjoying earnings that made them “the darlings of Wall Street,” one writer observed.19 Now that physicians controlled access to antibiotics and all other prescription drugs, their incomes began to climb rapidly, doubling from 1950 to 1970 (after adjusting for inflation). The AMA’s revenues from drug advertisements in its journals rose from $2.5 million in 1950 to $10 million in 1960, and not surprisingly, these advertisements painted a rosy picture. A 1959 review of drugs in six major medical journals found that 89 percent of the ads provided no information about the drugs’ side effects.20

Italian reporters uncovered evidence that the Vatican had invested in Istituto Farmacologico Serono, a pharmaceutical company that made birth control pills, as well as Udine, a military weapons manufacturer (there were also unconfirmed newspaper reports of church money in gunmaker Beretta, a Monte Carlo casino, and a printing firm that published pornographic magazines).

This is an existential threat to the social and economic order, which is why countries wage a stubborn, bloody and hopeless war on biochemical crime. The state hopes to regulate the biochemical pursuit of happiness, separating ‘bad’ manipulations from ‘good’ ones. The principle is clear: biochemical manipulations that strengthen political stability, social order and economic growth are allowed and even encouraged (e.g., those that calm hyperactive kids in school, or drive anxious soldiers forward into battle). Manipulations that threaten stability and growth are banned. But each year new drugs are born in the research labs of universities, pharmaceutical companies and criminal organisations, and the needs of the state and the market also keep changing.

In 1955 a drug company named Carter-Wallace released the anti-anxiety drug Miltown, reframing anxiety as the natural product of a society that was both dog-eat-dog and relentlessly social. Miltown was marketed to men and immediately became the fastest-selling pharmaceutical in American history, according to the social historian Andrea Tone. By 1956 one of every twenty Americans had tried it; by 1960 a third of all prescriptions from U.S. doctors were for Miltown or a similar drug called Equanil. “ANXIETY AND TENSION ARE THE COMMONPLACE OF THE AGE,” read the Equanil ad. The 1960s tranquilizer Serentil followed with an ad campaign even more direct in its appeal to improve social performance. “FOR THE ANXIETY THAT COMES FROM NOT FITTING IN,” it empathized.

The state hopes to regulate the biochemical pursuit of happiness, separating ‘bad’ manipulations from ‘good’ ones. The principle is clear: biochemical manipulations that strengthen political stability, social order and economic growth are allowed and even encouraged (e.g. those that calm hyperactive kids in school, or drive anxious soldiers forward into battle). Manipulations that threaten stability and growth are banned. But each year new drugs are born in the research labs of universities, pharmaceutical companies and criminal organisations, and the needs of the state and the market also keep changing. As the biochemical pursuit of happiness accelerates, so it will reshape politics, society and economics, and it will become ever harder to bring it under control.

months. Sometimes it becomes so severe that it gets a medical name: hyperemesis gravidarum. In such cases, it may require hospitalization. The most common theory for why women suffer morning sickness is that it encourages them to eat cautiously during the early stages of pregnancy, though that fails to explain why morning sickness then usually stops after a few weeks, when women should still probably be conservative in their food choices, or why women who eat a safe and bland diet get sick anyway. A big part of the reason that there are no cures for morning sickness is that the tragic experience in the 1960s of thalidomide, which was designed to combat morning sickness, left pharmaceutical companies permanently reluctant to try to make drugs of any type for pregnant women.

I’ll tell you the truth, Dr. Singh, what I have discovered about these trees is not what I expected. It will not be what your pharmaceutical company expects. It is something much greater, much more ambitious than anything we had hoped for. That was Dr. Rapp’s great lesson in the Amazon, in science: Never be so focused on what you’re looking for that you overlook the thing you actually find.

In 1955 a drug company named Carter-Wallace released the anti-anxiety drug Miltown, reframing anxiety as the natural product of a society that was both dog-eat-dog and relentlessly social. Miltown was marketed to men and immediately became the fastest-selling pharmaceutical in American history, according to the social historian Andrea Tone. By 1956 one of every twenty Americans had tried it; by 1960 a third of all prescriptions from U.S. doctors were for Miltown or a similar drug called Equanil.

We have to remember that the use of stimulating drugs was more common in the 1930’s and 40’s, and much less frowned upon, than it is today in the 1950’s. Let’s remember that Bayer, which I think is probably still the largest German pharmaceutical company, they invented their two wonder drugs in the 1930s, Aspirin and Heroin. They were intended to go hand in hand, if you remember back then (Aspirin = Hope, Heroin = Heroism.) You could get Heroin very easily from a pharmacist, just like Aspirin. Today

IN OCTOBER 2019, just a few months before the novel coronavirus swept the world, Johns Hopkins University released its first Global Heath Security Index, a comprehensive analysis of countries that were best prepared to handle an epidemic or pandemic. The United States ranked first overall, and first in four of the six categories—prevention, early detection and reporting, sufficient and robust health system, and compliance with international norms. That sounded right. America was, after all, the country with most of the world’s best pharmaceutical companies, research universities, laboratories, and health institutes. But by March 2020, these advantages seemed like a cruel joke, as Covid-19 tore across the United States and the federal government mounted a delayed, weak, and erratic response. By July, with less than 5% of the world’s population, the country had over 25% of the world’s cumulative confirmed cases. Per capita daily death rates in the United States were ten times higher than in Europe. Was this the new face of American exceptionalism?

With Britain preoccupied by World War II and the United States not yet in it, the quest to produce bulk penicillin moved to a U.S. government research facility in Peoria, Illinois. Scientists and other interested parties all over the Allied world were secretly asked to send in soil and mold samples. Hundreds responded, but nothing they sent proved promising. Then, two years after testing had begun, a lab assistant in Peoria named Mary Hunt brought in a cantaloupe from a local grocery store. It had a “pretty golden mold” growing on it, she recalled later. That mold proved to be two hundred times more potent than anything previously tested. The name and location of the store where Mary Hunt shopped are now forgotten, and the historic cantaloupe itself was not preserved: after the mold was scraped off, it was cut into pieces and eaten by the staff. But the mold lived on. Every bit of penicillin made since that day is descended from that single random cantaloupe. Within a year, American pharmaceutical companies were producing 100 billion units of penicillin a month.

The current ruling ontology denies any possibility of a social causation of mental illness. The chemico-biologization of mental illness is of course strictly commensurate with its depoliticization. Considering mental illness an individual chemico-biological problem has enormous benefits for capitalism. First, it reinforces Capital’s drive towards atomistic individualization (you are sick because of your brain chemistry). Second, it provides an enormously lucrative market in which multinational pharmaceutical companies can peddle their pharmaceuticals (we can cure you with our SSRIs). It goes without saying that all mental illnesses are neurologically instantiated, but this says nothing about their causation. If it is true, for instance, that depression is constituted by low serotonin levels, what still needs to be explained is why particular individuals have low levels of serotonin. This requires a social and political explanation; and the task of repoliticizing mental illness is an urgent one if the left wants to challenge capitalist realism. It does not seem fanciful to see parallels between the rising incidence of mental distress and new patterns of assessing workers’ performance.

And if the history of pharmaceutical consumption is any indication, many buckled under such pressures. In 1955 a drug company named Carter-Wallace released the anti-anxiety drug Miltown, reframing anxiety as the natural product of a society that was both dog-eat-dog and relentlessly social. Miltown was marketed to men and immediately became the fastest-selling pharmaceutical in American history, according to the social historian Andrea Tone. By 1956 one of every twenty Americans had tried it; by 1960 a third of all prescriptions from U.S. doctors were for Miltown or a similar drug called Equanil.

Xuan pulled out his phone and searched Google. He had to ask for the correct spelling of the drug. He wanted more real information about how much of a financial burden he would be to his parents. Money was a big concern. Possibly a deal breaker. “Several sites—it’s around five hundred dollars a day! That’s fifteen thousand a month! How could I let my parents pay that much for me?” Fifteen thousand dollars. I gasped, appalled. I staggered to the chair and collapsed into it. He’ll never agree to that. Xuan opened his mouth and closed it again, in shock. The atmosphere in the room plunged from friendly and informative to frigid with mathematical figures and calculations. I sat with my elbows on my knees, my face buried in my hands. Saints, I knew cancer treatment was expensive, but I never imagined it was that expensive. That was too much. Ironically, I didn’t know if I could live with myself, knowing my parents were working day and night to keep me alive. That would be a huge financial responsibility. I just couldn’t imagine allowing it, month after month. Sadly, I wondered how many people died every year because of the cost of medication in the United States. In a way, it seemed like pharmaceutical companies were getting away with murder.

Yet the new research into psychedelics comes along at a time when mental health treatment in this country is so “broken”—to use the word of Tom Insel, who until 2015 was director of the National Institute of Mental Health—that the field’s willingness to entertain radical new approaches is perhaps greater than it has been in a generation. The pharmacological toolbox for treating depression—which afflicts nearly a tenth of all Americans and, worldwide, is the leading cause of disability—has little in it today, with antidepressants losing their effectiveness* and the pipeline for new psychiatric drugs drying up. Pharmaceutical companies are no longer investing in the development of so-called CNS drugs—medicines targeted at the central nervous system. The mental health system reaches only a fraction of the people suffering from mental disorders, most of whom are discouraged from seeking treatment by its cost, social stigma, or ineffectiveness. There are almost forty-three thousand suicides every year in America (more than the number of deaths from either breast cancer or auto accidents), yet only about half of the people who take their lives have ever received mental health treatment. “Broken” does not seem too harsh a characterization of such a system.

The dramatic power of dopamine to interfere with free will and create sexual (and other) compulsions became clear when patients took drugs that imitate dopamine. For example, a Frenchman who took such a drug to control Parkinson’s symptoms recovered a large settlement from a pharmaceutical company after the medication temporarily gave him compulsive homosexual urges. (He was straight when not on the meds.)192 Another Parkinson’s patient suddenly found himself cross-dressing after seventy years of uneventful heterosexuality. When doctors decreased his dosage of the dopamine-like drug, the urge to put on his deceased wife’s clothing evaporated.

When any industry funds research, the findings are typically biased in favour of the funder73-78 – not in every single study, but overall this pattern is very consistent. This is true even for the pharmaceutical industry, which operates in an extraordinarily regulated research environment in which regulators have absolute power over how products are sold and can inspect every data point from every experiment. Compared with the pharma industry, the regulation of food company research, including the studies and papers cited here, is virtually non-existent. Manufacturers of soft drinks have been very successful at exploiting this lack of regulation.

Ultimately, one goal of this research is to create a “smart pill” that could boost concentration, improve memory, and maybe increase our intelligence. Pharmaceutical companies have experimented with several drugs, such as MEM 1003 and MEM 1414, that do seem to enhance mental function. Scientists have found that in animal studies, long-term memories are made possible by the interaction of enzymes and genes. Learning takes place when certain neural pathways are reinforced as specific genes are activated, such as the CREB gene, which in turn emits a corresponding protein. Basically, the more CREB proteins circulating in the brain, the faster long-term memories are formed. This has been verified in studies on sea mollusks, fruit flies, and mice. The key property of MEM 1414 is that it accelerates the production of the CREB proteins. In lab tests, aged animals given MEM 1414 were able to form long-term memories significantly faster than a control group. Scientists are also beginning to isolate the precise biochemistry required in the formation of long-term memories, at both the genetic and the molecular level. Once the process of memory formation is completely understood, therapies will be devised to accelerate and strengthen this key process. Not only the aged and Alzheimer’s patients but eventually the average person may well benefit from this “brain boost.

Some have estimated that the pharmaceutical industry overall spends about twice as much on marketing and promotion as it does on research and development. Regardless of how those two figures compare to each other, the fact that they are in the same ballpark gives one pause, and this is worth mulling over in various contexts. For example, when a drug company refuses to let a developing country have affordable access to a new AIDS drug it’s because – the company says – it needs the money from sales to fund research and development on other new AIDS drugs for the future. If R&D is a fraction of the company’s outgoings, and it spends a similar amount on promotion, then this moral and practical argument doesn’t hold water quite so well.

All the recent marketing successes have been PR successes, not advertising successes. To name a few: Starbucks, The Body Shop, Amazon.com, Yahoo!, eBay, Palm, Google, Linus, PlayStation, Harry Potter, Botox, Red Bull, Microsoft, Intel, and BlackBerry. A closer look at the history of most major brands shows this to be true. As a matter of fact, an astonishing number of well-known brands have been built with virtually no advertising at all. Anita Roddick built The Body Shop into a worldwide brand without any advertising. Instead she traveled the world looking for ingredients for her natural cosmetics, a quest that resulted in endless publicity. Until recently Starbucks didn’t spend a hill of beans on advertising either. In its first ten years, the company spent less that $10 million (total) on advertising in the United States, a trivial amount for a brand that delivers annual sales of $1.3 billion today. Wal-Mart became the world’s largest retailer, ringing up sales approaching $200 billion, with little advertising. Sam’s Club, a Wal-Mart sibling, averages $56 million per store with almost no advertising. In the pharmaceutical field, Viagra, Prozac, and Vioxx became worldwide brands with almost no advertising. In the toy field, Beanie Babies, Tickle Me Elmo, and Pokémon became highly successful brands with almost no advertising. In the high-technology field, Oracle, Cisco, and SAP became multibillion-dollar companies (and multibillion-dollar brands) with almost no advertising.

If you were going to start a bioengineering company, Henry, what would you do? Would you make products to help mankind, to fight illness and disease? Dear me, no. That’s a terrible idea. A very poor use of new technology.” Hammond shook his head sadly. “Yet, you’ll remember,” he said, “the original genetic engineering companies, like Genentech and Cetus, were all started to make pharmaceuticals. New drugs for mankind. Noble, noble purpose. Unfortunately, drugs face all kinds of barriers. FDA testing alone takes five to eight years—if you’re lucky. Even worse, there are forces at work in the marketplace. Suppose you make a miracle drug for cancer or heart disease—as Genentech did. Suppose you now want to charge a thousand dollars or two thousand dollars a dose. You might imagine that is your privilege. After all, you invented the drug, you paid to develop and test it; you should be able to charge whatever you wish. But do you really think that the government will let you do that? No, Henry, they will not. Sick people aren’t going to pay a thousand dollars a dose for needed medication—they won’t be grateful, they’ll be outraged. Blue Cross isn’t going to pay it. They’ll scream highway robbery. So something will happen. Your patent application will be denied. Your permits will be delayed. Something will force you to see reason—and to sell your drug at a lower cost. From a business standpoint, that makes helping mankind a very risky business. Personally, I would never help mankind.

Some have estimated that the pharmaceutical industry overall spends about twice as much on marketing and promotion as it does on research and development. Regardless of how those two figures compare to each other, the fact that they are in the same ballpark gives one pause, and this is worth mulling over in various contexts. For example, when a drug company refuses to let a developing country have affordable access to a new AIDS drug it’s because – the company says – it needs the money from sales to fund research and development on other new AIDS drugs for the future. If R&D is a fraction of the company’s outgoings, and it spends a similar amount on promotion, then this moral and practical argument doesn’t hold water quite so well. The scale of this spend is fascinating in itself, when you put it in the context of what we all expect from evidence-based medicine, which is that people will simply use the best treatment for the patient. Because when you pull away from the industry’s carefully fostered belief that this marketing activity is all completely normal, and stop thinking of drugs as being a consumer product like clothes or cosmetics, you suddenly realise that medicines marketing only exists for one reason. In medicine, brand identities are irrelevant, and there’s a factual, objective answer to whether one drug is the most likely to improve a patient’s pain, suffering and longevity. Marketing, therefore, one might argue, exists for no reason other than to pervert evidence-based decision-making in medicine.

But for this—” She stopped herself. He didn’t know. “Where is he now?” Marina asked. She could not bring herself to say his body. Anders was not a body. Vogel was full of doctors, doctors working, doctors in their offices drinking coffee. The cabinets and storage rooms and desk drawers were full of drugs, pills of every conceivable stripe. They were a pharmaceutical company; what they didn’t have they figured out how to make. Surely if they knew where he was they could find something to do for him, and with that thought her desire for the impossible eclipsed every piece of science she had ever known. The dead were dead were dead were dead and still Marina Singh did not have to shut her eyes to see Anders Eckman eating an egg salad sandwich in the employee cafeteria as he had done with great enthusiasm every day she had known him.

In March, at HHS’s request, several large pharmaceutical companies—Novartis, Bayer, Sanofi, and others—donated their inventory, a total of 63 million doses of hydroxychloroquine and 2 million of chloroquine, to the Strategic National Stockpile, managed by BARDA, an agency under the DHHS Assistant Secretary for Preparedness and Response.56 BARDA’s Director, Dr. Rick Bright, later claimed the chloroquine drugs were deadly, and he needed to protect the American public from them.57 Bright colluded with FDA to restrict use of the donated pills to hospitalized patients. FDA publicized the authorization using language that led most physicians to believe that prescribing the drug for any purpose was off-limits. But at the beginning of June, based on clinical trials that intentionally gave unreasonably high doses to hospitalized patients and failed to start the drug until too late, FDA took the unprecedented step of revoking HCQ’s emergency authorization,58 rendering that enormous stockpile of valuable pills off limits to Americans while conveniently indemnifying the pharmaceutical companies for their inventory losses by allowing them a tax break for the donations. After widespread use of the drug for 65 years, without warning, FDA somehow felt the need to send out an alert on June 15, 2020 that HCQ is dangerous, and that it required a level of monitoring only available at hospitals.59 In a bit of twisted logic, Federal officials continued to encourage doctors to use the suddenly-dangerous drug without restriction for lupus, rheumatoid arthritis, Lyme and malaria. Just not for COVID. With the encouragement of Dr. Fauci and other HHS officials, many states simultaneously imposed restrictions on HCQ’s use.

Do you really think that the Revolution is a ridiculous proposition? That we cannot engineer our own structures? What's ridiculous is the system we have now. If we were starting society anew, who among us would propose a monarchy, an aristocracy, a financial elite that exploits the earth and farms its population? If at one of the local or regional meetings that we have to govern our community someone proposed, instead of equality, that all of us, including the poorest among us, donated a percentage of our income to a super-rich family with a little old lady at its helm who would turn up annually in our parliament, draped in jewels and finery, to tell us that austerity had to continue, you'd tell them they were mental. If someone said that we should give 64 per cent of British land to 0.28 per cent of the population, we would not vote for it. If trade agreements were proposed that meant local businesses were shackled so that transnational corporations could create a farcical tyrannical economy where produce was needlessly transported around the world for their gain and to the detriment of everyone else, it would be forbidden. If energy companies said they wanted to be run for huge profit, without regulation, whilst harming the environment, we wouldn't allow it. That pharmaceutical and food companies could run their own governing bodies, flood the world with inferior and harmful products that damage and even kill the people that use them, we would not tolerate it. Here is the truth they fight so hard to suppress: to create a better world, the priority is not the implementation of new systems, though that is necessary, it is a refusal to cooperate with the obsolete and harmful structures that are already in place.

Ostholm’s managerial compass at Astra had been consistent for twenty-four years. Once, he spotted a distraught person, possibly Swiss, at Basel airport. When he walked up to him, he learnt that the young man had failed in his job interview at a pharmaceutical company. The researcher had an idea of preventing acid secretion in the stomach by shutting down proton pumps. After Ostholm showed interest, right there at the airport, the man drew a diagram to explain the idea. Ostholm asked if he had a molecule in mind. Convinced by the man’s reply, he instantly wrote him an offer letter and invited him to Stockholm. Astra was already working on anti-ulcers and the drug that Ostholm’s offer letter propelled was the multi-billion-dollar anti-ulcer drug Omeprazole which turned around Astra’s fortunes. If Ostholm sensed a scientist’s passion, he would brook no barrier to his/her support.

We follow what is happening with influenza virus strains in the Southern Hemisphere when it is their fall (our spring) to predict which influenza viruses will likely be with us the next winter. Some years that educated guess is more accurate than others. So is it worth getting the vaccination each year? I give that a qualified yes. It might or might not prevent you from getting flu. But even if it is only 30 to 60 percent effective, it sure beats zero protection. What we really need is a game-changing influenza vaccine that will target the conserved—or unchanging—features of the influenza viruses that are more likely to cause human influenza pandemics and subsequently seasonal influenza in the following years. How difficult would such a game-changing influenza vaccine be to achieve? The simple truth is that we don’t know, because we’ve never gotten a prototype into, let alone through, the valley of death. We need a new paradigm—a new business model that pairs public money with private pharmaceutical company partnerships and foundation support and guidance.

Dr. Fauci’s business closures pulverized America’s middle class and engineered the largest upward transfer of wealth in human history. In 2020, workers lost $3.7 trillion while billionaires gained $3.9 trillion.46 Some 493 individuals became new billionaires,47 and an additional 8 million Americans dropped below the poverty line.48 The biggest winners were the robber barons—the very companies that were cheerleading Dr. Fauci’s lockdown and censoring his critics: Big Technology, Big Data, Big Telecom, Big Finance, Big Media behemoths (Michael Bloomberg, Rupert Murdoch, Viacom, and Disney), and Silicon Valley Internet titans like Jeff Bezos, Bill Gates, Mark Zuckerberg, Eric Schmidt, Sergey Brin, Larry Page, Larry Ellison, and Jack Dorsey. The very Internet companies that snookered us all with the promise of democratizing communications made it impermissible for Americans to criticize their government or question the safety of pharmaceutical products; these companies propped up all official pronouncements while scrubbing all dissent. The same Tech/Data and Telecom robber barons, gorging themselves on the corpses of our obliterated middle class, rapidly transformed America’s once-proud democracy into a censorship and surveillance police state from which they profit at every turn.

How do you commit the perfect crime in science? We’re handicapped from the start because it’s a question we never ask. For more than thirty years, Frank taught me and many others to record our data accurately, compare them with collaborators around the world, discard the outliers, and come to a consensus. We understand there are variations, but if the bulk of the evidence goes in a certain direction, we are confident we have a better understanding of human biological processes. If only that were what happened in the real world. In the real world there are corporations, be they pharmaceutical, agricultural, petroleum, or chemical companies, that have billions of dollars at stake in the work of scientists. If one has billions of dollars, he can use the dark arts of persuasion to hire public relations firms to tout your products, sow the seeds of doubt about those who question your products, buy advertising on news networks so they don’t publicize negative stories unless they have no other choice, and donate to politicians of all ideologies. Then, once those politicians have been elected, they can write laws for the benefit of their generous donors. As it was put so eloquently in the seventeenth century by a prominent member of Queen Elizabeth’s court, “If it prospers, none dare call it treason.

Here is another example that demonstrates the tightly linked interests that both cause and treat cancer. In 1978, Imperial Chemical Industries (ICI), one of the largest companies in the world, specializing in agrochemicals and pharmaceuticals, developed the cancer drug tamoxifen. In 1985, along with the American Cancer Society, ICI founded the National Breast Cancer Awareness Month with the aim of promoting mammography as the most effective tool against breast cancer. In 1990 Imperial Chemical Industries was accused of dumping DDT and PCBs, known carcinogens, into the Long Beach and Los Angeles harbors. Zeneca, producer of tamoxifen, demerged from ICI in 1993, and later merged with Astra AB in 1999 to form AstraZeneca. Astra AB had developed the herbicide acetochlor, classified by the EPA as a probable carcinogen. In 1997 Zeneca purchased Salick Health Care, a chain of for-profit outpatient cancer clinics. Subsequently AstraZeneca launched a major publicity campaign encouraging women to assess their risk factors for breast cancer, downplaying the dangers of tamoxifen in order to create a market for its prophylactic, or chemopreventative, use and, more recently, for the breast cancer drug Arimidex (anastrozole), approved in 2002 and used as an alternative to tamoxifen (Arimidex went off patent in 2010).

If you were going to start a bioengineering company, Henry, what would you do? Would you make products to help mankind, to fight illness and disease? Dear me, no. That’s a terrible idea. A very poor use of new technology.” Hammond shook his head sadly. “Yet, you’ll remember,” he said, “the original genetic engineering companies, like Genentech and Cetus, were all started to make pharmaceuticals. New drugs for mankind. Noble, noble purpose. Unfortunately, drugs face all kinds of barriers. FDA testing alone takes five to eight years—if you’re lucky. Even worse, there are forces at work in the marketplace. Suppose you make a miracle drug for cancer or heart disease—as Genentech did. Suppose you now want to charge a thousand dollars or two thousand dollars a dose. You might imagine that is your privilege. After all, you invented the drug, you paid to develop and test it; you should be able to charge whatever you wish. But do you really think that the government will let you do that? No, Henry, they will not. Sick people aren’t going to pay a thousand dollars a dose for needed medication—they won’t be grateful, they’ll be outraged. Blue Cross isn’t going to pay it. They’ll scream highway robbery. So something will happen. Your patent application will be denied. Your permits will be delayed. Something will force you to see reason—and to sell your drug at a lower cost. From a business standpoint, that makes helping mankind a very risky business. Personally, I would never help mankind

In July 2018, a safety crisis rocked the global drug supply—and seemed to prove Baker’s point. Regulators in Europe announced a harrowing discovery: the widely used active ingredient for valsartan, a generic version of the blood pressure drug Diovan, contained a cancer-causing toxin known as NDMA (once used in liquid rocket fuel). The drug had been made by the Chinese company Zhejiang Huahai Pharmaceuticals, the world’s largest manufacturer of valsartan active ingredients. In the United States, over a dozen drug manufacturers, all of which used the Chinese ingredient, recalled their products, as did dozens more manufacturers around the world. The Chinese company tried to defend itself by explaining that it had altered its production process in 2012 to increase yields of the drug, a change that had been approved by regulators. In short, the change had been made to maximize profit. Some patients had been consuming the toxin for six years. As the FDA tried to reassure consumers that the risk of developing cancer, even from daily exposure to the toxin, was extremely low, a second cancer-causing impurity was detected in the ingredients. Though the valsartan catastrophe seemed to take the FDA by surprise, it shouldn’t have. In May 2017, an FDA investigator had found evidence at the plant in Linhai, China, that the company was failing to investigate potential impurities in its own drugs, which showed up as aberrant peaks in its test results. The investigator designated the plant as Official Action Indicated, but the agency downgraded that to VAI. In short, the company was let off the hook—only to wind up in the middle of a worldwide quality scandal less than a year later. By

Tim Tigner began his career in Soviet Counterintelligence with the US Army Special Forces, the Green Berets. That was back in the Cold War days when, “We learned Russian so you didn't have to,” something he did at the Presidio of Monterey alongside Recon Marines and Navy SEALs. With the fall of the Berlin Wall, Tim switched from espionage to arbitrage. Armed with a Wharton MBA rather than a Colt M16, he moved to Moscow in the midst of Perestroika. There, he led prominent multinational medical companies, worked with cosmonauts on the MIR Space Station (from Earth, alas), chaired the Association of International Pharmaceutical Manufacturers, and helped write Russia’s first law on healthcare. Moving to Brussels during the formation of the EU, Tim ran Europe, Middle East, and Africa for a Johnson & Johnson company and traveled like a character in a Robert Ludlum novel. He eventually landed in Silicon Valley, where he launched new medical technologies as a startup CEO. In his free time, Tim has climbed the peaks of Mount Olympus, hang glided from the cliffs of Rio de Janeiro, and ballooned over Belgium. He earned scuba certification in Turkey, learned to ski in Slovenia, and ran the Serengeti with a Maasai warrior. He acted on stage in Portugal, taught negotiations in Germany, and chaired a healthcare conference in Holland. Tim studied psychology in France, radiology in England, and philosophy in Greece. He has enjoyed ballet at the Bolshoi, the opera on Lake Como, and the symphony in Vienna. He’s been a marathoner, paratrooper, triathlete, and yogi.  Intent on combining his creativity with his experience, Tim began writing thrillers in 1996 from an apartment overlooking Moscow’s Gorky Park. Decades later, his passion for creative writing continues to grow every day. His home office now overlooks a vineyard in Northern California, where he lives with his wife Elena and their two daughters. Tim grew up in the Midwest, and graduated from Hanover College with a BA in Philosophy and Mathematics. After military service and work as a financial analyst and foreign-exchange trader, he earned an MBA in Finance and an MA in International Studies from the University of Pennsylvania’s Wharton and Lauder Schools.  Thank you for taking the time to read about the author. Tim is most grateful for his loyal fans, and loves to correspond with readers like you. You are welcome to reach him directly at tim@timtigner.com.

The Western medical model — and I don't mean the science of it, I mean the practice of it, because the science is completely at odds with the practice — makes two devastating separations. First of all we separate the mind from the body, we separate the emotions from the physiology. So we don't see how the physiology of people reflects their lifelong emotional experience. So we separate the mind from the body, which is not something that traditional medicine has done, I mean, Ayuverdic or Chinese medicine or shamanic tribal cultures and medicinal practices throughout the world have always recognized that mind and body are inseparable. They intuitively knew it. Many Western practitioners have known this and even taught it, but in practice we ignore it. And then we separate the individual from the environment. The studies are clear, for example, that when people are emotionally isolated they tend to get sick more quickly and they succumb more rapidly to their disease. Why? Because people's physiology is completely related to their psychological, social environment and when people are isolated and alone their stress levels are much higher because there's nothing there to help them moderate their stress. And physiologically it is straightforward, you know, it takes a five-year-old kid to understand it. However because in practice we separate them... when somebody shows up with an inflamed joint, all we do is we give them an anti-inflammatory or because the immune system is hyperactive and is attacking them we give them a medication to suppress their immune system or we give them a stress hormone like cortisol or one of its analogues, to suppress the inflammation. But we never ask: "What does this manifest about your life?", "What does this say about your relationships?", "How stressful is your job?", "To what extent do you lack control in your life?", "Where are you not authentic?", "How are you trying to work so hard to meet your attachment needs by suppressing yourself?" (because that is what you learn to do as a kid). Then we do all this research that has to do with cell biology, so we keep looking for the cause of cancer in the cell. Now there's a wonderful quote in the New York Times a couple of years ago they did a series on cancer and somebody said: "Looking for the cause of cancer inside the individual cell is like trying to understand a traffic jam by studying the internal combustion engine." We will never understand it, but we spend hundreds of billions of dollars a year looking for the cause of cancer inside the cell, not recognizing that the cell exists in interaction with the environment and that the genes are modulated by the environment, they are turned on and off by the environment. So the impact of not understanding the unity of emotions and physiology on one hand and in the other hand the relationship between the individual and the environment.. in other words.. having a strictly biological model as opposed to what has been called a bio-psycho-social, that recognizes that the biology is important, but it also reflects our psychological and social relationships. And therefore trying to understand the biology in isolation from the psychological and social environment is futile. The result is that we are treating people purely through pharmaceuticals or physical interventions, greatly to the profit of companies that manufacture pharmaceuticals and which fund the research, but it leaves us very much in the dark about a) the causes and b) the treatment, the holistic treatment of most conditions. So that for all our amazing interventions and technological marvels, we are still far short of doing what we could do, were we more mindful of that unity. So the consequences are devastating economically, they are devastating emotionally, they are devastating medically.

Like all best supporting actors, the state may also step centre stage, taking entrepreneurial risks where the market and commons can’t or won’t reach. The extraordinary success of tech companies such as Apple is sometimes held up as evidence of the market’s dynamism. But Mariana Mazzucato, an expert in the economics of government-led innovation, points out that the basic research behind every innovation that makes a smart phone ‘smart’—GPS, microchips, touchscreens and the Internet itself—was funded by the US government. The state, not the market, turns out to have been the innovating, risk-taking partner, not ‘crowding out’ but ‘dynamising in’ private enterprise—and this trend holds across other high-tech industries too, such as pharmaceuticals and biotech.42 In the words of Ha-Joon Chang, ‘If we remain blinded by the free market ideology that tells us only winner-picking by the private sector can succeed, we will end up ignoring a huge range of possibilities for economic development through public leadership or public-private joint efforts.

Men! God only put them on earth so pharmaceutical companies would have a market for Prozac and Valium.

During an interview with Diversity Inc.’s director of research and product development, she walked me through a typical presentation used to pitch the value of the company’s software to prospective clients. I learned that their products are especially valuable to those industries not allowed to collect ethno-racial data directly from individuals because of civil rights legislation that attempts to curb how these data are used to discriminate. But now those who work in finance, housing, and healthcare can use predictive software programs to ascertain information that they cannot request directly. The US Health Insurance Portability and Accountability Act (HIPAA) privacy rule, for example, strictly monitors the collection, storage, and communication of individuals’ “protected health information,” among other features of the law. This means that pharmaceutical companies, which market to different groups, need indirect methods to create customer profiles, because they cannot collect racial-ethnic data directly. This is where Diversity Inc. comes in. Its software programs target customers not only on the basis of race and ethnicity, but also on the basis of socioeconomic status, gender, and a growing list of other attributes. However, the company does not refer to “race” anywhere in their product descriptions. Everything is based on individuals’ names, we are told. “A person’s name is data,” according to the director of research and product development. She explains that her clients typically supply Diversity Inc. with a database of client names and her team builds knowledge around it. The process, she says, has a 96 percent accuracy rate, because so many last names are not shared across racial–ethnic groups – a phenomenon sociologists call “cultural segregation.”18

nevertheless pleaded guilty to criminal charges and paid a $3 billion fine for promoting its antidepressants for unapproved uses and failing to report safety data about a top diabetes drug. It was the largest settlement recorded involving a pharmaceutical company. The agreement also included civil penalties for improper marketing of a half-dozen

The dysfunctional state of the American political system is the best reason to be pessimistic about our country’s future. Our scientific and technological prowess is the best reason to be optimistic. We are an inventive people. The United States produces ridiculous numbers of patents,114 has many of the world’s best universities and research institutions, and our companies lead the market in fields ranging from pharmaceuticals to information technology. If I had a choice between a tournament of ideas and a political cage match, I know which fight I’d rather be engaging in—especially if I thought I had the right forecast.

Janet, a chemist and a team leader at a pharmaceutical company, received glowing comments from her peers and superiors during her 360-degree review but was surprised by the negative feedback she got from her direct reports. She immediately concluded that the problem was theirs: “I have high standards, and some of them can’t handle that,” she remembers thinking. “They aren’t used to someone holding their feet to the fire.” In this way, she changed the subject from her management style to her subordinates’ competence, preventing her from learning something important about the impact she had on others. Eventually the penny dropped, Janet says. “I came to see that whether it was their performance problem or my leadership problem, those were not mutually exclusive issues, and both were worth solving.” She was able to disentangle the issues and talk to her team about both. Wisely, she began the conversation with their feedback to her, asking, “What am I doing that’s making things tough? What would improve the situation?

The August 2000 Congressional investigation found that the majority of ACIP members were conflicted in that vote.103 That report found that seven out of ten ACIP working group committee members who voted to approve the rotavirus vaccine in June 1998 had financial ties to the pharmaceutical companies that were developing different versions of the vaccine. According to

Encouraged by relaxed licensing requirements, pharmaceutical companies have flooded the market with unnecessary, poorly tested, and ineffective vaccines since the late 1970s. The focus is on creating wealth and jobs rather than quality products backed by sound medical and scientific evidence. In the United States alone, there are currently eighty trademarked canine vaccines, and as many for cats. It is possible to vaccinate animals against thirty diseases and counting. In 1998, vaccination specialist Dr. Richard B. Ford warned, “Most of these vaccines are so useless as to be called ‘vaccines in search of diseases.

Pharmaceutical companies don’t care about curing disease, they care about shareholders and stock dividends.

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After all, if the rainforest was really ‘nature’s medicine cabinet’, oozing with new penicillins and improved morphines, then the big pharmaceutical companies would have been buying up Brazil for a thousand euros an acre.

It is a well-known fact, and one that has given much ground for complaint, that after women have lost their genital function their character often undergoes a peculiar alteration, they become quarrelsome, vexatious and overbearing, petty and stingy, that is to say that they exhibit typically sadistic and anal-erotic traits which they did not possess earlier during their period of womanliness,” Sigmund Freud declared in 1913.8 Well, you can argue that he was a man of his time; the first couple of decades of the twentieth century weren’t exactly known for their respect for women’s finer qualities. But unfortunately, the nonsense didn’t stop there. “The unpalatable truth must be faced that all postmenopausal women are castrates,” pronounced American gynecologist Robert Wilson in a 1963 essay;9 he then elaborated fulsomely on this theme in his 1966 bestseller Feminine Forever.10 This frighteningly influential book, it later emerged, was backed by a pharmaceutical company eager to market hormone replacement therapy. “Once the ovaries stop, the very essence of being a woman stops,” psychiatrist David Reuben wrote in 1969 in another bestseller, Everything You Always Wanted to Know About Sex but Were Afraid to Ask.11 The postmenopausal woman, he added, comes “as close as she can to being a man.” Or rather, “not really a man but no longer a functional woman.” Half a century on, has anything really changed? Sadly, I don’t think so. It might not be acceptable in most circles to write that kind of thing anymore, but menopausal women are too often the butt of men’s jokes for me really to believe that the attitudes themselves have shifted. They’ve just gone a little more underground. So if these are the stories men are telling about us, where are the stories we’re telling about ourselves? Unfortunately, they’re not always very much more helpful. A surprising number of self-help or quasi-medical books by female authors toe the male line, enjoining women to try to stay young and beautiful at all costs, and head off to their doctor to get hormone replacement therapy to hold off the “symptoms” of the dreaded aging “disease” for as long as possible. Their aim, it seems, is above all a suspension of the aging process, an exhortation to live in a state of suspended animation. And although more women are beginning to write about menopause as a natural and profoundly transformational life-passage, in the culture at large it is still primarily viewed as something to be managed, held off, even fought.

I AM INDEBTED ABOVE ALL TO DR. ARNOLD S. (Bud) Relman, with whom I share my life. Together we wrote an extended article about the pharmaceutical industry called “America’s Other Drug Problem—The Insatiable Greed of the Pharmaceutical Industry.” It was published in the December 16, 2002, issue of The New Republic, and received the 2002 George Polk Award for magazine reporting. In outline, the pres-ent book largely follows that article.

He padded his training with substances to improve his abilities, though he was hardly the only one. Strychnine stimulated muscle activity. Nitroglycerine improved his breathing, though it risked hallucinations and exhaustion. Ether deadened his pains, even while he rode, one hand removed from the handlebars, a handkerchief lifted to his face. It was tolerated by everyone—pharmaceutical companies advertised in l’Auto, and the drugs were freely given out by team trainers. Henri rubbed chloroform against his gums and dropped liquid cocaine into the corners of his eyes. He avoided alcohol due to its lingering effects the next day, but in that year’s Tour, it was unclear what the state of drinking water would be in cities closer to the front.

The Love of Money It is not money in itself but the “love of money” that is the root of all evil. When the threat of Climate Change became a national crisis, the families of noted politicians began investing their money in “new green technology,” including solar panels, wind turbines, and electric cars, as informed investors invest where future money is to be made. When COVID hit, there were already certain pharmaceuticals that were used to treat the virus, including one I took that helped me within 48 hours. However, these pills have been available for many years to help prevent malaria but were ignored or not permitted to be sold, as the companies creating the vaccines and various doctors put the word out that these pills were not effective, and only the vaccine would work. According to whistleblower-doctors, the underlying reason for rejecting a cheaper pill is because vaccines would create more money.

Pharmaceutical companies were not content to hawk medications; they were also marketing psychological disorders themselves

Pharmaceutical companies were not content to hawk medications; they were also marketing psychological disorders themselves.

In business studies, value is understood as being created inside the company by bringing together managerial expertise, strategic thinking and a dynamic (changing with circumstances) division of labour between workers.3 All this ignores the massive role of government in creating value, and taking risk in the process. In The Entrepreneurial State I argued that Silicon Valley itself is an outcome of such high-risk investments by the state, willing to take risks in the early stages of development of high-risk technologies which the private sector usually shies away from.4 This is the case with the investments that led to the internet, where a critical role was played by DARPA, the Defence Advanced Research Projects Agency inside the US Department of Defense – and also by CERN in Europe with its invention of the World Wide Web. Indeed, not only the internet but nearly every other technology that makes our smart products smart was funded by public actors, such as GPS (funded by the US Navy), Siri (also funded by DARPA) and touch-screen display (funded initially by the CIA). It is also true of the high-risk, early-stage investments made in the pharmaceutical industry by public actors like the National Institutes of Health (NIH) – without which most blockbuster drugs would not have been developed. And the renewable energy industry has been greatly aided by investments made by public banks like the European Investment Bank or the KfW in Germany, with private finance often too risk-averse and focused on short-term returns.

MITI, far from being a uniquely brilliant leader of government/industrial partnership, has been wrong so often that the Japanese themselves will concede that much of their growth derives from industry's rejection of MITI’s guidance. MITI, incredibly, opposed the development of the very areas where Japan has been successful: cars, electronics and cameras. MITI has, moreover, poured vast funds into desperately wasteful projects. Thanks to MITI, Japan has a huge overcapacity in steel - no less than three times the national requirement. This, probably the most expensive mistake Japan ever made in peacetime, was a mistake of genius, because Japan has no natural resources: it has to import everything; the iron ore, the coal, the gas, the limestone and the oil to make its unwanted steel. Undaunted, MITI then invested in giant, loss-making (£400 million losses by 1992) 5th generation supercomputers at the precise moment that the market opened for the small personal computer; and MITI' s attempts at dominating the world's pharmaceutical and telecommunications industries have each failed. Nor is this just anecdote. In a meticulous study of MITI’s interventions into the Japanese economy between 1955 and 1990, Richard Beason of Alberta University and David Weinterin of Harvard showed that, across the 13 major sectors of the economy, surveying hundreds of different companies, Japan's bureaucrats almost invariably picked and supported the losers.

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During the Cold War, the US military and intelligence agencies largely replaced Europe’s colonial armies in those regions, supporting virtually any tinhorn dictator who proved his “anti-Communist” bona fides by rolling out red carpets for US multinationals. When the Berlin Wall fell, the United States already had 655 military bases (now 800)80 across the developing world, and US companies had blank checks in host nations to extract agricultural, mineral, petroleum, and lumber resources, and large markets for finished goods including, notably, pharmaceuticals

As usual, there was no investigation of Dr. Fauci or the other medical officials who choreographed this multibillion-dollar fraud. The pharmaceutical companies walked away with billions, sticking governments and taxpayers with the ruinous cost of compensating flu shot injuries.

The 1980 Bayh–Dole Act8 allowed NIAID—and Dr. Fauci personally—to file patents on the hundreds of new drugs that his agency-funded PIs were incubating, and then to license those drugs to pharmaceutical companies and collect royalties on their sales.

The Rockefeller Foundation launched a “public-private partnership” with pharmaceutical companies called the International Health Commission, which set about feverishly inoculating the hapless populations of the colonized tropics with a yellow fever jab.56 The vaccine killed its beneficiaries in droves and failed to prevent yellow fever. The Rockefeller Foundation quietly dropped the useless vaccine after the foundation’s star researcher, the yellow fever vaccine’s inventor, Hideyo Noguchi, succumbed to the disease, likely contracted through careless laboratory exposure.

His obsequious subservience to the Big Ag, Big Food, and pharmaceutical companies has left our children drowning in a toxic soup of pesticide residues, corn syrup, and processed foods, while also serving as pincushions for 69 mandated vaccine doses by age 18—none of them properly safety tested.55

Is this because any serious investigation into the sources of the chronic disease epidemic would certainly implicate the powerful pharmaceutical companies and the chemical, agricultural, and processed food multinationals that Dr. Fauci and his twenty-year business partner, Bill Gates, have devoted their careers to promoting?

Thus, if any FDA-approved drug like hydroxychloroquine (or ivermectin) proved effective against COVID, pharmaceutical companies would no longer be legally allowed to fast-track their billion-dollar vaccines to market under Emergency Use Authorization. Instead, vaccines would have to endure the years-long delays that have always accompanied methodical safety and efficacy testing, and that would mean less profits,

The prospect of an existing therapeutic drug (with an expired patent) that could outperform any vaccine in the war against COVID posed a momentous threat to the pharmaceutical cartel. Among the features pharma companies most detest is low cost, and HCQ is about $10 per course.41 Compare that to more than $3000 per course for Dr. Fauci’s beloved remdesivir.

Long-term funding became the first requirement of any new research. The researcher got his financing, and Dr. Fauci and the pharmaceutical company got proprietary rights on new discoveries. The self-interest of the researcher, the research institution, and the biotech company converged. Finance dictated the direction of research and—too often—warped its conclusions.

Bill Gates came to Pharma’s rescue. Gates helped pharmaceutical companies unload their thimerosal inventories by dumping them in developing countries.

This was the birth not only of the Merck Company, which still thrives today, but of the modern pharmaceutical industry as a whole. When injections were invented in 1850, there was no stopping the victory parade of morphine. The painkiller was used in the American Civil War of 1861–65 and in the Franco-Prussian War of 1870–71. Soon morphine fixes were doing the rounds as normal procedure.2

The vast majority of research into whether drugs work or not is funded by big pharmaceutical companies, and they do this research for a specific reason: they want to be able to market those drugs so they can make a profit out of them.

The profound misery that Akathisia symptoms cause has ruined my daily existence, making basic chores and personal passions impossible. A sense of futility and alienation has replaced the delight of simple joys and successes. My once-vibrant existence has been reduced to survival, interspersed by occasional relief from Georgie, my cat. Georgie's company has given me hope that life can still be full of unconditional love and simple joy, even at its worst periods. This great adversity inspires me to persevere. While my circumstances appear overwhelming, my tenacity in despair shows the invincible human spirit. Georgie's constant presence has taught me that there is always something to live for, even in despair. Healing is possible, and joy and meaning in life, however elusive, are within grasp. I face my problems with this weak but growing hope, determined to find my way back to a meaningful and happy existence.

By the early 1990s it had some $9 billion.26 And so, under the watch of chief financial officer Henri B. Meier, Roche set about putting its cash pile in an array of investments that had nothing to do with pharmaceuticals. That was how, in 1994, thanks to an introduction by Marc Rich’s financial adviser Heinz Pauli, the pharmaceutical company came to Strothotte’s rescue. Unlike Ebner, Roche had no interest in how the company was run – it just wanted to make money. Strothotte agreed to sell 15% of the company’s shares for about $150 million, with a promise to buy them back at a later date and a guarantee that Roche would receive a certain return on its investment.

Health insurance companies have created a financial black hole in an already broken healthcare system.

Jiyoung lay on her stomach on the floor to do homework, she clutched her cramping lower abdomen and repeated to herself, “I don’t understand. Half the population in the world goes through this every month. If a pharmaceutical company were to develop an effective pill specifically for menstrual cramps, not the ‘pain medication’ that makes you sick, they would make a fortune.” Her sister filled a plastic bottle with hot water, wrapped it in a towel and passed it to her. “You’re right. In a world where doctors can cure cancer and do heart transplants, there isn’t a single pill to treat menstrual cramps.” Her sister pointed at her own stomach. “The world wants our uterus to be drug-free. Like sacred grounds in a virgin forest.” Jiyoung hugged the bottle to her stomach and cackled despite the pain.

Thus, if any FDA-approved drug like hydroxychloroquine (or ivermectin) proved effective against COVID, pharmaceutical companies would no longer be legally allowed to fast-track their billion-dollar vaccines to market under Emergency Use Authorization

And so, in labs that neither they nor we will ever seen, more millions of animals must endure internal bleeding, convulsions, seizures, paralysis, and slow death. A stroll through the laboratories of Pfizer or any other pharmaceutical company, of Emory or many other universities, of the EPA, Consumer Safety Commission, Food and Drug Administration, Department of Defense, and a dozen other federal agencies would reveal similar scenes. It is easy to say, a priori, "It has to be done - it's the safety and progress." But we ourselves neither pay that price nor even look at the cost.

As I make clear throughout the book, OxyContin was hardly the only opioid to be fraudulently marketed or widely abused, and my choice to focus on Purdue is in no way a suggestion that other pharmaceutical companies do not deserve a great deal of blame for the crisis. The same could be said for the FDA, the doctors who wrote prescriptions, the wholesalers that distributed the opioids, and the pharmacies that filled the prescriptions. There’s plenty of blame to go around. I do share the view, however, of many doctors, public officials, prosecutors, and scholars that Purdue played a special role, as a pioneer. All

And so, in labs that neither they nor we will ever seen, more millions of animals must endure internal bleeding, convulsions, seizures, paralysis, and slow death. A stroll through the laboratories of Pfizer or any other pharmaceutical company, of Emore or many other universities, of the EPA, Consumer Safety Commission, Food and Drug Administration, Department of Defense, and a dozen other federal agencies would reveal similar scenes. It is easy to say, a priori, "It has to be done - it's the safety and progress." But we ourselves neither pay that price nor even look at the cost.

Under Dr. Fauci’s management, NIAID has become the center of a web of corrupting financial ties with the pharmaceutical industry. Dr. Fauci’s NIAID looks much more like a drug company than any sort of agency to advance science.

A month later Dr. Cartwright sends me a note of congratulations. He has been able to make an arrangement with Merck, the pharmaceutical giant, for access to the immunotherapy drug here at Duke, and the news fills me with a bright hope. No more 3:45 a.m. wakeups. No more hours on the phone with airline companies, trying to fix a haywire flight--- or relying on donations to afford the flights in the first place. A painful chapter of my life will finally close.

From the outset, hydroxychloroquine (HCQ) and other therapeutics posed an existential threat to Dr. Fauci and Bill Gates’ $48 billion COVID vaccine project, and particularly to their vanity drug remdesivir, in which Gates has a large stake.1 Under federal law, new vaccines and medicines cannot quality for Emergency Use Authorization (EUA) if any existing FDA-approved drug proves effective against the same malady: For FDA to issue an EUA (emergency use authorization), there must be no adequate, approved, and available alternative to the candidate product for diagnosing, preventing, or treating the disease or condition. . . .2 Thus, if any FDA-approved drug like hydroxychloroquine (or ivermectin) proved effective against COVID, pharmaceutical companies would no longer be legally allowed to fast-track their billion-dollar vaccines to market under Emergency Use Authorization. Instead, vaccines would have to endure the years-long delays that have always accompanied methodical safety and efficacy testing, and that would mean less profits, more uncertainty, longer runways to market, and a disappointing end to the lucrative COVID-19 vaccine gold rush. Dr. Fauci has invested $6 billion in taxpayer lucre in the Moderna vaccine alone.3 His agency is co-owner4 of the patent and stands to collect a fortune in royalties. At least four of Fauci’s hand-picked deputies are in line to collect royalties of $150,000/year based on Moderna’s success, and that’s on top of the salaries already paid by the American public.5,6

Under federal law, new vaccines and medicines cannot quality for Emergency Use Authorization (EUA) if any existing FDA-approved drug proves effective against the same malady: For FDA to issue an EUA (emergency use authorization), there must be no adequate, approved, and available alternative to the candidate product for diagnosing, preventing, or treating the disease or condition. . . .2 Thus, if any FDA-approved drug like hydroxychloroquine (or ivermectin) proved effective against COVID, pharmaceutical companies would no longer be legally allowed to fast-track their billion-dollar vaccines to market under Emergency Use Authorization. Instead, vaccines would have to endure the years-long delays that have always accompanied methodical safety and efficacy testing, and that would mean less profits, more uncertainty, longer runways to market, and a disappointing end to the lucrative COVID-19 vaccine gold rush. Dr. Fauci has invested $6 billion in taxpayer lucre in the Moderna vaccine alone.3 His agency is co-owner4 of the patent and stands to collect a fortune in royalties. At least four of Fauci’s hand-picked deputies are in line to collect royalties of $150,000/year based on Moderna’s success, and that’s on top of the salaries already paid by the American public.5

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outlets including HuffPost, Politico, and The Daily Beast.86 Media platforms uniformly identify Offit as a “vaccine expert” from the University of Pennsylvania and the Children’s Hospital of Philadelphia (CHOP). With Offit’s encouragement, they seldom, if ever, disclose his pervasive financial entanglements with Dr. Fauci and the pharmaceutical companies.

The “J. Edgar Hoover of public health” has presided over cataclysmic declines in public health, including an exploding chronic disease epidemic that has made the “Fauci generation”—children born after his elevation to NIAID kingpin in 1984— the sickest generation in American history, and has made Americans among the least healthy citizens on the planet. His obsequious subservience to the Big Ag, Big Food, and pharmaceutical companies has left our children drowning in a toxic soup of pesticide residues, corn syrup, and processed foods, while also serving as pincushions for 69 mandated vaccine doses by age 18—none of them properly safety tested.55 When Dr. Fauci took office, America was still ranked among the world’s healthiest populations. An August 2021 study by the Commonwealth Fund ranked America’s health care system dead last among industrialized nations, with the highest infant mortality and the lowest life expectancy.

This is all the fault of that stupid pill I took. I’m going to find out which pharmaceutical company manufactures them and I’m going to write them a letter demanding they warn patients of the risk of extremely erotic dreams that make you do insane, reckless things like let hot but dangerous men go down on you.

In June 2017, for example, a cyber attack called “NotPetya” disabled computer systems worldwide. The ransomware attacks disrupted everything from radiation monitoring at the Chernobyl nuclear site to shipping operations in India, and its victims ranged from Russian oil company Rosneft to American pharmaceutical giant Merck.

In the nineteenth century the global economy was worth a little more than $1 trillion, in today’s money. That means each year capital needed to find new investments worth about $30 billion – a significant sum. This required a huge effort on the part of capital, including the colonial expansion that characterised the nineteenth century. Today the global economy is worth over $80 trillion, so to maintain an acceptable rate of growth capital needs to find outlets for new investments worth another $2.5 trillion next year. That’s the size of the entire British economy – one of the biggest in the world. Somehow we have to add the equivalent of another British economy next year, on top of what we are already doing, and then add even more than that the following year, and so on. Where can this quantity of growth possibly be found? The pressures become enormous. It’s what is driving the pharmaceutical companies behind the opioid crisis in the United States; the beef companies that are burning down the Amazon; the arms companies that lobby against gun control; the oil companies that bankroll climate denialism; and the retail firms that are invading our lives with ever-more sophisticated advertising techniques to get us to buy things we don’t actually want. These are not ‘bad apples’ – they are obeying the iron law of capital. Over the past 500 years, an entire infrastructure has been created to facilitate the expansion of capital: limited liability, corporate personhood, stock markets, shareholder value rules, fractional reserve banking, credit ratings – we live in a world that’s increasingly organised around the imperatives of accumulation.

Explore the vibrant landscape of pharma companies in Mumbai, with a focus on Ciron Pharma. Discover how this industry leader is shaping the healthcare landscape and meet your pharmaceutical needs effectively.

Had ketamine been a new drug, pharmaceutical companies would have had a strong incentive to fund the kind of robust clinical trials federal regulators would have required to approve its use as a treatment for depression. But ketamine’s patent expired in 2002, which meant there was little to gain by bankrolling years of costly research.

For the APA and pharma companies, the emergence of NAMI could not have come at a more opportune moment. This was a parents’ group eager to embrace biological psychiatry, and both the APA and pharmaceutical firms pounced. In 1983, the APA “entered into an agreement with NAMI” to write a pamphlet on neuroleptic drugs, and soon the APA was encouraging its branches across the country “to foster collaborations with local chapters of the National Alliance for the Mentally Ill.”61 The APA and NAMI joined together to lobby Congress to increase funding for biomedical research, and the beneficiary of that effort, the NIMH—which saw its research budget soar 84 percent during the 1980s—thanked the parents for it. “The NIMH in a very meaningful sense is NAMI’s institute,” Judd told NAMI president Laurie Flynn in a 1990 letter.62 By that time, NAMI had more than 125,000 members, most of whom were middle-class, and it was busily seeking to “educate the media, public officials, healthcare providers, educators, the business community, and the general public about the true nature of brain disorders,” said one NAMI leader.63 NAMI brought a powerful moral authority to the telling of the broken-brain story, and naturally pharmaceutical companies were eager to fund its educational programs, with eighteen firms giving NAMI $11.72 million from 1996 to 1999.64

The FDA, of course, was not the only beneficiary of the pharmaceutical industry’s largesse. Its tentacles reached deep into the corridors of power in Washington. Between 1998 and 2006, the drug companies spent a total of $1.2 billion on lobbying and political contributions in the United States, according to the Center for Responsive Politics, a nonprofit, nonpartisan research group that tracks money in politics. In 2002, the pharmaceutical industry ranked tenth among the top industries in political contributions and seventh in the amount of money it spent on lobbying members of Congress and others.

His obsequious subservience to the Big Ag, Big Food, and pharmaceutical companies has left our children drowning in a toxic soup of pesticide residues, corn syrup, and processed foods, while also serving as pincushions for 69 mandated vaccine doses by age 18—none of them properly safety tested.

In "Shyness: How Normal Behavior Became a Sickness" (2007) Christopher Lane describes how pharmaceutical companies helped to persuade the American Psychiatric Association to include social phobia in the "DSM" of 1980. He argues that the diagnosis in many cases turned a personality trait into an illness, pathologising people who were resvered, private or quiet. 'Over the course of six years,' he writes, 'a small group of self-selecting American psychiatrists built a sweeping new consensus: shyness and a host of comparable traits were anxiety and personality disorders. And they stemmed not from psychological conflicts or social tensions, but rather from a chemical imbalance or faulty neurotransmitters in the brain.' Lane believes that there is a great cost to medicalising our quirks, eccentricities and ordinary feelings. "The sad consequence,' he says, 'is a vast, perhaps irrecoverable, loss of emotional range, an impovershment of human experience.

Mental health is an enormous business; in the United States, more money is spent on mental health conditions than any other medical specialty, with an estimated $201 billion spent in 2013 alone and an estimated increase to $280 billion by 2020 (Substance Abuse and Mental Health Services Administration, 2014). More than half of the budget for the American Psychiatric Association is income received directly from pharmaceutical companies, and drug-makers are the most frequent and largest donors of mental health advocacy groups (see, e.g., Harris, 2009). Speaking and consulting gigs for the pharmaceutical industry can earn psychiatrists up to $1 million or more in direct fees per year,4 and at least 70% of the professionals making up the task force for the DSM were tied to pharmaceutical companies (Cosgrove & Krimsky, 2012), raising concerns about corporate interests reflected in practice and policy and accusations of disease mongering (Moynihan, Heath, & Henry, 2002). The incentive for ensuring the medical and biological framework for conceptualizing problems in living is huge.

These men and others, including pharmaceutical companies and the US government, are sending millions of dollars to LGBT causes. Overall, reported global spending on LGBT is now estimated at $560 million (from 2017–2018).

O’Sullivan and Field (2018) provide a case study of systemically team coaching an Australian pharmaceutical company in this process.

At the time, the pharmaceutical company tried and failed to launch a new drug that had the potential to make millions of dollars. It kept getting flagged by the FDA because of detrimental side effects. Your father voted on certain laws that allowed AstraRx to bypass some of the red tape and ease the distribution of the drug into the market.” “Oh, my God.” I slump in my chair and bow my head. “Are you saying that my father knowingly helped put a dangerous drug into the hands of the public in exchange for funding?

In case you missed that, a high-carbohydrate diet, like the one your doctor, the government, and the pharmaceutical companies endorse, is the type of diet that makes small, dense reactive LDL particles.

Sort pills. Write note to family. Fold blanket. I am alone. Alone in a dark, unfamiliar room filled with piles and piles of stuff, reminiscent of a neglected storage locker. I know researchers are observing me from behind one-way glass—that this is an experiment in empathy, that we are, in fact, on the sprawling campus of a pharmaceutical company in New Jersey, that I can rip off the headphones at any moment and return to my present life, my real life—but this offers me no comfort. I can barely see through the goggles. My feet hurt. Every step is agony, the sharp plastic spikes digging into my soles. Sort pills. Write note to family. Fold blanket. I try to make out the shapes around me. I see an ironing board, a stack of sweaters. A ball of twine. My determination to cross items off any to-do list—always a strong suit of mine—feels slippery. Suddenly, I am a child playing hide-and-seek in the dark. Counting. Eyes squeezed shut. Terrified. Wondering if anyone will ever find me. Blanket. Pills. Note. I keep repeating the words like a prayer so I can remember them through the terrible din. The inside of my head is a needle against a scratched record, skipping, skipping. I feel my way around a cluttered table. A pill case! I try to pick it up. I barely feel it in the palm of my hand. After several tries, I get it open. Then I begin to sort the pills as best I can. Most of them spill to the floor, and I am suddenly, irrationally furious. I move around the table, supporting myself on my hands to take the pressure off my feet. I push an iron out of the way, a magazine, a wooden hanger. The notebook. I find the notebook. My gloved fingers won’t close around a pencil, so I hold it the way a child would, in my fist. By now it all feels nearly futile. I’m on the verge of tears. What is the last task? Through the static, I remember: the blanket. I have to fold it. By now I’m dizzy, depleted. What difference can it possibly make? Who cares? I do a shitty job of folding the blanket and then—then I just sit down in a chair and wait for M. to rescue me. —

Big weddings meant big money and, with Bee's fiancé, Kevin Yu, from a family that owned a big pharmaceutical company, big attention. Personally, I wanted to know if she planned to change her name, switching from Bee Little to Bee Yu, but had not found a way to work this into a meeting. Yet.

pharmaceutical companies spend tens of billions of pounds every year trying to change the treatment decisions of doctors: in fact, they spend twice as much on marketing and advertising as they do on the research and development of new drugs. Since we all want doctors to prescribe medicine based on evidence, and evidence is universal, there is only one possible reason for such huge spends: to distort evidence-based practice.

The US dietary guidelines were the first ever to inform the general public about what should not be eaten. Specifically, we were told to avoid fat, especially saturated fat, and to replace dietary saturated fats with carbohydrates and polyunsaturated ‘vegetable’ (actually seed) oils. Failure to do so, we were warned, would cause us all to die of heart attacks, because cholesterol, we were told, causes coronary heart disease. Instead, the advice drove us down the road to obesity and the much more severe form of arterial disease caused by T2DM. Some have described this monumental error as the greatest scam in the history of modern medicine. The fallout has produced some very big ‘winners’, specifically those pharmaceutical companies that have benefited from the sale of the largely ineffective statin drugs, and the processed-food industry, dominated by 10 companies that produce the ‘displacing foods of modern commerce

My worst ever speech was one I did for a pharmaceutical company in South Africa. They were paying me $1,000 and my airfare. It was a fortune to me at the time, and I couldn’t believe my luck. That would last Shara and me for months. I soon found myself at a hotel in the Drakensberg Mountains, waiting for six hundred sales staff to arrive at the conference center. Their bus journey up had been a long one and they had been supplied with beer, nonstop, for the previous five hours. By the time they rolled off the buses, many of them were tripping over their bags--laughing and roaring drunk. Nightmare. I had been asked to speak after dinner--and for a minimum of an hour. Even I knew that an hour after dinner was suicide. But they were insistent. They wanted their thousand’s worth. After a long, booze-filled dinner that never seemed to end, the delegates really were totally paralytic. I was holding my head in my hands backstage. Sweet Jesus. Then, just as I walked out on stage, the lights went out and there was a power cut. You have got to be joking. The organizers found candles to light the room (which also meant no slides), and then I was on. It was well after midnight by now. Oh, and did I mention that all the delegates were Afrikaans-speaking, so English was their second language, at best? Sure enough, the heckling started before I even opened my mouth. “We don’t want an after-dinner speaker,” one drunk man shouted, almost falling off his chair. Listen, nor do I, big fella, I thought. I suspect it was just as painful an hour for him as it was for me. But I persevered and endeavored to learn how to tell a story well. After all, it was my only source of work, and my only way of trying to find new sponsors for any other expeditions that I hoped to lead.

About a quarter of the money taken by pharmaceutical companies for the drugs they sell is turned around into promotional activity which has, as we will see, a provable impact on doctors' prescribing. So we pay for products, with a huge uplift in price to cover their marketing budgets, and that money is then spent on distorting evidence-based practice, which in turn makes our decisions unnecessarily expensive, and less effective.

Embracing Failure WE NEED TO FAIL. Churches need to fail more. Leaders need to fail more. Pharmaceutical giant Eli Lilly has, since the 1990s, been hosting what he calls failure parties for scrapped research projects. 1 Edgy design company 5Crowd has a failure party every month—complete with failure high-fives and often wrapping up with a celebratory failure cake! 2 When venture capitalists assess whether to invest in a new idea, one of the key characteristics they look for is a previous failed startup. They prefer to invest in a leader who has already run a company into the ground.

They invited a large investor, Coca-Cola, to take over a plot of land in Pulkovo Heights and install high-capacity power and communications cables, hoping that other companies would follow suit. It worked. After Coca-Cola developed their piece of land, Gillette came, then Wrigley, and then some pharmaceutical companies. An economic zone thus took shape within the city, where total investment now exceeds half a billion dollars. Furthermore, with the Committee’s encouragement, the city’s infrastructure began to be modernized to create the conditions necessary for successful business. The first major deal that Putin supported was the completion of a fiber-optic cable to Copenhagen. This project had been initiated back in the Soviet era but never completed. Now the efforts were successful, providing St. Petersburg with world-class international telephone connections.

The vast majority of curricula that are taught in medical schools in this country were put together by organizations that were founded by, or are funded by, pharmaceutical companies. 

What’s more, a real premium began to be placed on being part of this knowledge oeuvre—not just in what McKinsey knew but in who at McKinsey knew these subject areas. An unstated understanding emerged that if you were a logistics expert in, say, the retail sector and you were called by a partner you had never met who mainly did work with pharmaceutical companies, you would nevertheless return the call. That reputation for contributing was your asset in the firm.

Clip This Article on Location 1397 | Added on Monday, September 1, 2014 4:10:39 PM REVIEW & OUTLOOK An $8.3 Billion Rebuke to the FDA Roche buys a drug approved in Europe but not in America. 359 words Amid this summer's M&A fever, Roche's agreement Monday to buy the San Francisco biotech InterMune deserves special notice. The tie-up is an $8.3 billion guided missile into the fortified bunker that is the Food and Drug Administration. InterMune has never turned a profit in 16 years of existence and other than its clinical expertise the company holds a single asset: an idea for treating a lethal lung disorder called idiopathic pulmonary fibrosis with no known cause, cure or approved therapy—at least in the U.S. An InterMune drug called pirfenidone that slows the progression of irreversible lung scarring is on the market in Europe, Japan, Canada and even China. Bloomberg News But the FDA refused to approve pirfenidone in 2010, despite the 40,000 Americans who are killed annually by lung fibrosis and a positive recommendation from its outside scientific advisory committee. The agency brass claimed the evidence was statistically unsatisfactory, when one clinical trial was inconclusive but another showed strong benefits such as improved lung function. The results of the third trial the FDA ordered were reported earlier this year and confirmed that pirfenidone is even more of a treatment advance than it seemed in 2010, and may prolong life. The agency is expected, finally, to approve the medicine in November. Roche is paying a 38% premium over Friday's closing share price, and 63% over trading before the news of InterMune's corporate suitors broke a few weeks ago. The deal is a big vote of confidence in pirfenidone, not least because a rival lung fibrosis drug is awaiting U.S. approval. Then again, maybe that drug's maker, the German pharmaceutical consortium Boehringer Ingelheim, will have the same FDA experience as InterMune. The Roche deal is a tacit reprimand to the FDA's unscientific and uncompassionate—and wrong—2010 defenestration. Amid medical ambiguity about effectiveness, the humane option is to allow a drug to come to patients and follow on with more research, in particular for a drug with few side effects. Pulmonary fibrosis is a protracted death sentence of three to five years. The FDA denied tens of thousands of dying people better and possibly longer lives in the time they had left. ==========

University of California Economics Professor Robert Reich identified six principles of the new populism : 1. Cut the biggest Wall Street banks down to a size where they're no longer too big to fail. 2. Resurrect the Glass-Steagall Act, the law separating investment from commercial banking thereby preventing companies from gambling with their depositors' money. 3. End corporate welfare including subsidies to big oil, agribusiness, pharmaceuticals,

It was clearly stated by Drs. Lacasse and Leo in their 2005 paper: “These advertisements present a seductive concept, and the fact that patients are now presenting with a self-described ‘chemical imbalance’ shows that the [advertising] is having its intended effect: the medical marketplace is being shaped in a way that is advantageous to the pharmaceutical companies.

He should know better than to panic monger himself, that was for the media and the pharmaceutical companies to do.

not put in place, one wonders how insurance and pharmaceutical companies will treat our grandchildren if they have genetic information about them, perhaps even before they are even conceived. Insurance

But large fines don’t appear to affect the questionable practices of pharmaceutical companies; such practices will not change until drug executives are singled out for punishment.

You cannot put a strategy in place today in the pharmaceutical industry, in the automobile industry, in the food industry with less than a seven- to ten-year time frame. That’s how long it takes. Particularly [for] companies going through a cultural transformation it takes closer to ten years to get it done.”14

The notion that hormonal contraception could keep a newly formed oocyte from adhering to the uterine wall had no scientific basis. The pharmaceutical company that had first marketed the pill in the fifties had made the claim—without any scientific data—because they thought it would help sell the product. Now a growing number of anti-abortion activists, including some doctors, believed it to be factual. Marketing was the glue that held myths together.

PRIME Prime is an ever-changing condition, a segment of a journey, not a haven at the end of the road. Companies in Prime are recognizable: All aspects work well together, all operations thrive, and all members of the organization know where it is going and how to stay on track. Prime is a state of balance: Flexibility and control, function and form, imagining and producing, innovation and administration. But companies in that exultant equilibrium — so hard to achieve, so easy to lose — continually risk sliding back to childish habits or stumbling into the rigidity of old age. An organization is no less vulnerable in Prime than it is at any other stage of its lifecycle. The cash shortage of Infancy, the founder’s heavy hand in Go-Go, the infighting of Adolescence — those are challenges it has overcome. Now the complacency that comes with a surfeit of success looms as a potential and significant threat. I have a rule of thumb by which I judge an adult company: If it does not produce significant new products or spin off promising start-ups within any three-year period, it is either decaying or on the brink of decline. Ask yourself what percentage of your revenues come from products you were not selling three years ago? Be honest. There are enhancements, changes that are cosmetic in nature that make old products look new. Pharmaceutical manufacturers are well known for

What’s behind these terribly low diagnostic rates? “One of the reasons celiac disease is so grossly underdiagnosed in this country,” says Dr. Green, “is that the pharmaceutical industry has such a major role in the direction of health care here. In many countries around the world, where there are national health plans, doctors are actively encouraged to diagnose celiac disease. In this country, the pharmaceutical industry provides eighty percent of the money for medical research. It also provides a lot of money for postgraduate education, and there just aren’t any drug companies that are interested in researching celiac disease. There’s basically no money in it—no drug company will provide funds for the research.” Simply put: Since there are no drugs to treat celiac disease, pharmaceutical companies stand to gain no profits from encouraging its diagnosis.

In universities and pharmaceutical labs around the world, computer scientists and computational biologists are designing algorithms to sift through billions of gene sequences, looking for links between certain genetic markers and diseases. The goal is to help us sidestep the diseases we're most likely to contract and to provide each one of us with a cabinet of personalized medicines. Each one should include just the right dosage and the ideal mix of molecules for our bodies. Between these two branches of research, genetic and behavioral, we're being parsed, inside and out. Even the language of the two fields is similar. In a nod to geneticists, Dishman and his team are working to catalog what they call our "behavioral markers." The math is also about the same. Whether they're scrutinizing our strands of DNA or our nightly trips to the bathroom, statisticians are searching for norms, correlations, and anomalies. Dishman prefers his behavioral approach, in part because the market's less crowded. "There are a zillion people looking at biology," he says, "and too few looking at behavior." His gadgets also have an edge because they can provide basic alerts from day one. The technology indicating whether a person gets out of bed, for example, isn't much more complicated than the sensor that automatically opens a supermarket door. But that nugget of information is valuable. Once we start installing these sensors, and the electronics companies get their foot in the door, the experts can start refining the analysis from simple alerts to sophisticated predictions-perhaps preparing us for the onset of Parkinson's disease or Alzheimer's.