Neurons Quotes

Where did feelings go when they disappeared? Did they leave a chemical trace somewhere in our minds, so that if we could look inside ourselves we would see via the patterns of neurons some of the important things that had happened to us in our lifetimes?

I am a collection of oddities, a circus of neurons and electrons: my heart is the ringmaster, my soul is the trapeze artist, and the world is my audience. It sounds strange because it is, and it is, because I am strange.

I believed, and still do, that our bodies are our selves, that my soul is the voltage conducted through neurons and nerves, and that my spirit is my flesh.

Foulmouthed individuals seem to have their neuron systems replaced by colon structures, given that their terminology profusely consists of "sh*t and f*ck". ("Tolerance zero")

Whatever we call it - mind, character, soul - we like to think we possess something that is greater than the sum of our neurons and that animates us.

As a bio major, I figured "free will" meant chemicals in your brain telling you what to do, the molecules bouncing around in a way that felt like choosing but was actually the dance of little gears--neurons and hormones bubbling up into decisions like clockwork. You don't use your body; it uses you.

Any man could, if he were so inclined, be the sculptor of his own brain.

Emotional states are fairly quick bursts of neuronal gossip. Traits, on the other hand, are more like the neuronal equivalent of committed relationships.

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.

A three-day-old human embryo is a collection of 150 cells called a blastocyst. There are, for the sake of comparison, more than 100,000 cells in the brain of a fly. The human embryos that are destroyed in stem-cell research do not have brains, or even neurons. Consequently, there is no reason to believe they can suffer their destruction in any way at all. It is worth remembered, in this context, that when a person's brain has died, we currently deem it acceptable to harvest his organs (provided he has donated them for this purpose) and bury him in the ground. If it is acceptable to treat a person whose brain has died as something less than a human being, it should be acceptable to treat a blastocyst as such. If you are concerned about suffering in this universe, killing a fly should present you with greater moral difficulties than killing a human blastocyst. Perhaps you think that the crucial difference between a fly and a human blastocyst is to be found in the latter's potential to become a fully developed human being. But almost every cell in your body is a potential human being, given our recent advances in genetic engineering. Every time you scratch your nose, you have committed a Holocaust of potential human beings.

The robot had no feelings, only positronic surges that mimicked those feelings. (And perhaps human beings had no feelings, only neuronic surges that were interpreted as feelings.)

The neural processes underlying that which we call creativity have nothing to do with rationality. That is to say, if we look at how the brain generates creativity, we will see that it is not a rational process at all; creativity is not born out of reasoning.

Are You Ready for New Urban Fragrances? Yeah, I guess I'm ready, but listen: Perfume is a disguise. Since the middle ages, we have worn masks of fruit and flowers in order to conceal from ourselves the meaty essence of our humanity. We appreciate the sexual attractant of the rose, the ripeness of the orange, more than we honor our own ripe carnality. Now today we want to perfume our cities, as well; to replace their stinging fumes of disturbed fossils' sleep with the scent of gardens and orchards. Yet, humans are not bees any more than they are blossoms. If we must pull an olfactory hood over our urban environment, let it be of a different nature. I want to travel on a train that smells like snowflakes. I want to sip in cafes that smell like comets. Under the pressure of my step, I want the streets to emit the precise odor of a diamond necklace. I want the newspapers I read to smell like the violins left in pawnshops by weeping hobos on Christmas Eve. I want to carry luggage that reeks of the neurons in Einstein's brain. I want a city's gases to smell like the golden belly hairs of the gods. And when I gaze at a televised picture of the moon, I want to detect, from a distance of 239,000 miles, the aroma of fresh mozzarella.

Maybe compassion and empathy are just squishy emotions. Illusions created by our mirror neurons. But does it really matter where they come from? They make us human. They might be what make us worth saving.

Even then, more than a year earlier, there were neurons in her head, not far from her ears, that were being strangled to death, too quietly for her to hear them. Some would argue that things were going so insiduously wrong that the neurons themselves initiated events that would lead to their own destruction. Whether it was molecular murder or cellular suicide, they were unable to warn her of what was happening before they died.

Perhaps eggs are like neurons, which also are not replenished in adulthood: they know too much. Eggs must plan the party. Sperm need only to show up- wearing top hat and tails, of course.

God is a cluster of neurons.

Neurons that fire together wire together. Mental states become neural traits. Day after day, your mind is building your brain. This is what scientists call experience-dependent neuroplasticity,

The point is, the brain talks to itself, and by talking to itself changes its perceptions. To make a new version of the not-entirely-false model, imagine the first interpreter as a foreign correspondent, reporting from the world. The world in this case means everything out- or inside our bodies, including serotonin levels in the brain. The second interpreter is a news analyst, who writes op-ed pieces. They read each other's work. One needs data, the other needs an overview; they influence each other. They get dialogues going. INTERPRETER ONE: Pain in the left foot, back of heel. INTERPRETER TWO: I believe that's because the shoe is too tight. INTERPRETER ONE: Checked that. Took off the shoe. Foot still hurts. INTERPRETER TWO: Did you look at it? INTERPRETER ONE: Looking. It's red. INTERPRETER TWO: No blood? INTERPRETER ONE: Nope. INTERPRETER TWO: Forget about it. INTERPRETER ONE: Okay. Mental illness seems to be a communication problem between interpreters one and two. An exemplary piece of confusion. INTERPRETER ONE: There's a tiger in the corner. INTERPRETER TWO: No, that's not a tiger- that's a bureau. INTERPRETER ONE: It's a tiger, it's a tiger! INTERPRETER TWO: Don't be ridiculous. Let's go look at it. Then all the dendrites and neurons and serotonin levels and interpreters collect themselves and trot over to the corner. If you are not crazy, the second interpreter's assertion, that this is a bureau, will be acceptable to the first interpreter. If you are crazy, the first interpreter's viewpoint, the tiger theory, will prevail. The trouble here is that the first interpreter actually sees a tiger. The messages sent between neurons are incorrect somehow. The chemicals triggered are the wrong chemicals, or the impulses are going to the wrong connections. Apparently, this happens often, but the second interpreter jumps in to straighten things out.

If we are lucky, the end of the sentence is where we might begin. If we are lucky, something is passed on, another alphabet written in the blood, sinew, and neuron; ancestors charging their kin with the silent propulsion to fly south, to turn toward the place in the narrative no one was meant to outlast.

Biological neurons operate at a peak speed of about 200 Hz, a full seven orders of magnitude slower than a modern microprocessor (~ 2 GHz).

The human brain, it has been said, is the most complexly organised structure in the universe and to appreciate this you just have to look at some numbers. The brain is made up of one hundred billion nerve cells or "neurons" which is the basic structural and functional units of the nervous system. Each neuron makes something like a thousand to ten thousand contacts with other neurons and these points of contact are called synapses where exchange of information occurs. And based on this information, someone has calculated that the number of possible permutations and combinations of brain activity, in other words the numbers of brain states, exceeds the number of elementary particles in the known universe.

There are two types of empathy: the positive empathy and the negative empathy. When we are fully carried away by the unaware activities of the mirror neurons, we are under the trap of negative empathy. The negative empathy generates attachments. Out of these attachments suffering follows. Negative empathy is a kind of reaction to a situation, whereas positive empathy is internal response of peace love and tranquility.... In positive empathy, your deep tranquility, joy and peace activates the mirror neurons of the others, whereas in negative empathy your mirror neurons are activated by the disturbance of others.

My neurons number half a billion, and they are distributed among my eight arms. On occasion, I have wondered whether I might have more intelligence in a single tentacle than a human does in its entire skull.

I maintain that the human mystery is incredibly demeaned by scientific reductionism, with its claim in promissory materialism to account eventually for all of the spiritual world in terms of patterns of neuronal activity. This belief must be classed as a superstition.... we have to recognize that we are spiritual beings with souls existing in a spiritual world as well as material beings with bodies and brains existing in a material world.

There must be a way, I thought, that language of life as experienced-- of passion, of hunger, of love-- bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

Buddhist say that thoughts are like drops of water on the brain; when you reinforce the same thought, it will etch a new stream into your consciousness, like water eroding the side of a mountain. Scientist confirm this bit of folk wisdom: our neurons break connections and form new pathways all the time. Even if you've been programmed to fear death, that particular pathway isn't set in stone. Each of us is responsible for seeking out new knowledge and creating mental circuits.

Simulating the behavior of 100 billion neurons of human brain is not feasible by classical computer but quantum machine learning promises to fulfill that requirement.

...an effective psychotherapist or psychoanalyst is a "microsurgeon of the mind" who helps patients make needed alterations in neuronal networks.

But evolution is not a precise mechanism, and it has resulted in a certain number of people in the population with more nerves than neurons.

Like daffodils in the early days of spring, my neurons were resprouting receptors as the winter of the illness ebbed.

The well-being of a neuron depends on its ability to communicate with other neurons. Studies have shown that electrical and chemical stimulation from both a neuron's inputs and its targets support vital cellular processes. Neurons unable to connect effectively with other neurons atrophy. Useless, an abandoned neuron will die.

What is memory? It's not something you can physically hold, or see, or smell, or taste. It's just nerve impulses jumping between neurons. Sometimes it's a matter of choice. Other times it's self-preservation, or protection" -Leight

As modern-day neuroscience tells us, we are never in touch with the present, because neural information-processing itself takes time. Signals take time to travel from your sensory organs along the multiple neuronal pathways in your body to your brain, and they take time to be processed and transformed into objects, scenes, and complex situations. So, strictly speaking, what you are experiencing as the present moment is actually the past.

The brief span of an individual life is misleading. Each one of us is as old as the entire biological kingdom, and our bloodstreams are tributaries of the great sea of its total memory. The uterine odyssey of the growing foetus recapitulates the entire evolutionary past, and its central nervous system is a coded time scale, each nexus of neurones and each spinal level marking a symbolic station, a unit of neuronic time.

What do we mean by "knowledge" or "understanding"? And how do billions of neurons achieve them? These are complete mysteries. Admittedly, cognitive neuroscientists are still very vague about the exact meaning of words like "understand," "think," and indeed the word "meaning" itself.

Each person you meet influences your mental universe in a way that has the potential to make a substantial impact upon the causality of the intellectual development of an entire species.

You don't stop loving someone just because they do something that surprises or even disappoints you. Maybe facts and formulas comfort Marcus, but I think that article he read was totally wrong. You don't love chemical reactions or particles or neuron receptors. You love whole people. Including the parts you didn't know were there, and the parts you're waiting for them to become.

When you travel, you're forced to have new thoughts. "Is this alley safe?" "Is this the right bus?" "Was this meat ever a house pet?" It doesn't even matter what the new thoughts are, it feels so good to just have some variety. And it's a reboot for your brain. I can feel the neurons making new connections again with new problems to solve, clawing their way back to their nimbler, younger days.

Love makes you crazy. Love crawls into your brain and plays games with your neurons. All the things you thought you knew about yourself fly out the window when love flies in.

Quantum coherence in the ion channels of the neurons and the neural circuits in the brain creates the decision behaviors and quantum cognition.

She wasn't stupid. She just didn't want to put her neuron power into long sentences.

The parts of your brain that are now activated include the same neurons in your visual cortex that would be activated if you were actually looking

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were. And brain cells weren’t even the lower limit. The origins of thought were buried so deep they predated multicellular life itself: neurotransmitters in choanoflagellates, potassium ion gates in Monosiga. I am a colony of microbes talking to itself, Brüks reflected.

Your mind is the projection screen every writer steals; it is the firing of your neurones that makes every book come alive. You are the electricity that turns it on. A book cannot live until the touch of your hand on the first page brings it alive. A writer is essentially typing blank pages – shouting out spells in the dark – until the words are read by you, and the magic explodes into your head, and no one else's.

From a pathological standpoint, the incipient twenty-first century is determined neither by bacteria nor by viruses, but by neurons. Neurological illnesses such as depression, attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), and burnout syndrome mark the landscape of pathology at the beginning of the twenty-first century. They are not infections, but infarctions; they do not follow from the negativity of what is immunologically foreign, but from an excess of positivity. Therefore, they elude all technologies and techniques that seek to combat what is alien.

Whatever we call it - mind, character, soul - we like to think we possess something that is greater than the sum of our neurons that 'animates' us.

Some years ago, there was a lovely philosopher of science and journalist in Italy named Giulio Giorello, and he did an interview with me. And I don’t know if he wrote it or not, but the headline in Corriere della Sera when it was published was "Sì, abbiamo un'anima. Ma è fatta di tanti piccoli robot – "Yes, we have a soul, but it’s made of lots of tiny robots." And I thought, exactly. That’s the view. Yes, we have a soul, but in what sense? In the sense that our brains, unlike the brains even of dogs and cats and chimpanzees and dolphins, our brains have functional structures that give our brains powers that no other brains have - powers of look-ahead, primarily. We can understand our position in the world, we can see the future, we can understand where we came from. We know that we’re here. No buffalo knows it’s a buffalo, but we jolly well know that we’re members of Homo sapiens, and it’s the knowledge that we have and the can-do, our capacity to think ahead and to reflect and to evaluate and to evaluate our evaluations, and evaluate the grounds for our evaluations. It’s this expandable capacity to represent reasons that we have that gives us a soul. But what’s it made of? It’s made of neurons. It’s made of lots of tiny robots. And we can actually explain the structure and operation of that kind of soul, whereas an eternal, immortal, immaterial soul is just a metaphysical rug under which you sweep your embarrassment for not having any explanation.

When the brain is working to remember something, similar patterns of neurons fire as they did during the perception of the original event. These networks are linked, and each time we revisit them, they become stronger and more associated. But they need the proper retrieval cues--words, smells, images-- for them to be brought back as memories

Could a machine ever be said to have made its own decisions? Could a machine have beliefs? Could a machine make mistakes? Could a machine believe it made its own decisions? Could a machine erroneously attribute free will to itself? Could a machine come up with ideas that had not been programmed into it in advance? Could creativity emerge from a set of fixed rules? Are we – even the most creative among us – but passive slaves to the laws of physics that govern our neurons?

...what draws us into a story and keeps us there is the firing of our dopamine neurons, signaling that intriguing information is on the way.

You die a little inside every time you have joyless sex. Neurons prune back. The good in there withers. And some things never grow back.

Just a dozen of high quality qudits will be sufficient to simulate the state of 100 billion neurons of human brain for quantum machine learning.

Well, they say trauma etches the neurons, and I was traumatized by my appalling behavior.” Typical, Theo thought. He’d been accused, yet she was traumatized.

Time is basically an illusion created by the mind to aid in our sense of temporal presence in the vast ocean of space. Without the neurons to create a virtual perception of the past and the future based on all our experiences, there is no actual existence of the past and the future. All that there is, is the present.

Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn't it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain? Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don't want to go to Montana. How do I know I really want to go and it isn't just some neurons firing or something? Maybe it's just an accidental flash in the medulla and suddenly there I am in Montana and I find out I really didn't want to go there in the first place. I can't control what happens in my brain, so how can I be sure what I want to do ten seconds from now, much less Montana next summer? It's all this activity in the brain and you don't know what's you as a person and what's some neuron that just happens to fire or just happens to misfire.

I understand the mechanism of my own thinking. I know precisely how I know, and my understanding is recursive. I understand the infinite regress of this self-knowing, not by proceeding step by step endlessly, but by apprehending the limit. The nature of recursive cognition is clear to me. A new meaning of the term "self-aware." Fiat logos. I know my mind in terms of a language more expressive than any I'd previously imagined. Like God creating order from chaos with an utterance, I make myself anew with this language. It is meta-self-descriptive and self-editing; not only can it describe thought, it can describe and modify its own operations as well, at all levels. What Gödel would have given to see this language, where modifying a statement causes the entire grammar to be adjusted. With this language, I can see how my mind is operating. I don't pretend to see my own neurons firing; such claims belong to John Lilly and his LSD experiments of the sixties. What I can do is perceive the gestalts; I see the mental structures forming, interacting. I see myself thinking, and I see the equations that describe my thinking, and I see myself comprehending the equations, and I see how the equations describe their being comprehended. I know how they make up my thoughts. These thoughts.

When a monkey loses a banana to a rival, he feels bad, but he doesn't expand the problem by thinking about it over and over. He looks for another banana. He ends up feeling rewarded rather than harmed. Humans use their extra neurons to construct theories about bananas and end up constructing pain.

I guess at some point we fell in love, whatever that means. What the fuck is love anyway? Is it mutual dependance; two bipolar opposites bringing their failings together, making a comprehensive hole? Is it needing someone around all the time, just to feel like yourself? Is it a form of madness— all those cells & neurons giggling like moon-happy coyotes? Is it missing someone, feeling a physical craving for them, even when they are lying right next to you? Yes, I guess we fell in love.

And now all those brain cells are dead – and my mother – who in a sense was the complex electrochemical interaction of all these millions of neurons – is no more. In neuroscience it is called ‘the binding problem’ – the extraordinary fact, which nobody can even begin to explain, that mere brute matter can give rise to consciousness and sensation. I had such a strong sensation, as she lay dying, that some deeper, ‘real’ person was still there behind the death mask.

Those smooth, spit-cleaned cheeks gave no indication of the dreams crowding her skull. Should she make it to adulthood, the girl would arrive with two hundred and six bones. Two and a half million sweat glands. Ninety-six thousand kilometers of blood vessels. Forty-six chromosomes. Seven meters of small intestines. Six hundred and six discrete muscles. One hundred billion cerebral neurons. Two kidneys. A liver. A heart. A hundred trillion cells that died and were replaced, again and again. But no matter how many ways she dismembered and quantified the body lying beside her, she couldn't say how many years the girl would wait before she married, if at all, or how many children she would have, if any; and between the creation of this body and its end lay the mystery the girl would spend her life solving.

If I could fall in love with a girl, it’d be her. Those ifs are dangerous. You try them on in your head like dresses, so easy to slide in and out of. If I kissed girls, I’d kiss her. If we kissed, it’d go like this. At some point I dropped the if like a slip and just wore the feeling, nothing between it and my skin. When I kiss her. When it happens. All of it took place in my head, in silence, locked tight in skull bone and the frantic synaptic whispers between neurons, no clues popping out except the passive-aggressive haircut, the incriminating poem. That’s the problem with writers. Too much imagination. The greater part of me knew it couldn’t be real, but the hopeful part, which is more concentrated and condensed, rich in nine essential delusions, thought: It’s not all in your head.

The neurons that do expire are the ones that made imitation possible. When you are capable of skillful imitation, the sweep of choices before you is too large; but when your brain loses its spare capacity, and along with it some agility, some joy in winging it, and the ambition to do things that don't suit it, then you finally have to settle down to do well the few things that your brain really can do well--the rest no longer seems pressing and distracting, because it is now permanently out of reach. The feeling that you are stupider than you were is what finally interests you in the really complex subjects of life: in change, in experience, in the ways other people have adjusted to disappointment and narrowed ability. You realize that you are no prodigy, your shoulders relax, and you begin to look around you, seeing local color unrivaled by blue glows of algebra and abstraction.

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were.

In the beginning, God created the neuron, and when electricity flowed through the three-dimensional nerve cell matrix in the brain, there was consciousness.

A good idea is a network. A specific constellation of neurons—thousands of them—fire in sync with each other for the first time in your brain, and an idea pops into your consciousness.

Most of the different types of cells in our body die and are replaced every few weeks or months. However, neurons, the primary cell of the nervous system, do not multiply (for the most part) after we are born. That means that the majority of the neurons in your brain today are as old as you are. This longevity of the neurons partially accounts for why we feel pretty much the same on the inside at the age of 10 as we do at age 30 or 77.

What makes aerobic exercise so powerful is that it’s our evolutionary method of generating that spark. It lights a fire on every level of your brain, from stoking up the neurons’ metabolic furnaces to forging the very structures that transmit information from one synapse to the next.

The mind and body are linked together in a meshwork of oxygen, nutrients, hormones, and neuron health. Physical exercise drives that meshwork, stimulating the brain and freeing one’s intellect.

In humans as well, it is because your loved one existed that certain neurons fire together and certain proteins are folded in your brain in particular ways. It is because your loved one lived, and because you loved each other, that means when the person is no longer in the outer world, they still physically exist—in the wiring of the neurons of your brain.

It is interesting to note that although our limbic system functions throughout our lifetime, it does not mature. As a result, when our emotional "buttons" are pushed, we retain the ability to react as though we were a two year old, even when we are adults. As our higher cortical cells mature and become integrated in complex networks with other neurons, we gain the ability to take "new pictures" of the present moment. When we compare the new information of our thinking mind with the automatic reactivity of our limbic mind, we can reevaluate the current situation and purposely choose a more mature response.

The brain represented the most complex organism ever to exist, and impossible to tame. Morality could not be spawned by tweaking a few genes or shutting off a few neurons. Not yet. So though humanity conquered the very stars, it remained unable to conquer the darkness within.

In short, the brain has the power to recruit healthy neurons to perform the function of the damaged ones. Neuroplasticity enables the brain to reassign jobs.

Six qudit virtual photon simulator is our first approach to develop the behavior of 100 billion neurons and to build the core quantum machine learning platform.

(...) a course laid between the seed and the snare marks of venerable syringes ordered to excite the awareness of Transcendence first and last harbour the disinfecting of exile on the bridge no one, only me, searching for approaches and testing traitor neurons grading thoughts repenting in an incomprehensible tongue and again attempting to show the splash-down of a world which moves up and down within the walls of experience a tragedy which travels unruffled hell without sinners without return (...)

...he'd know about the role of mirror neurons in the brain, special cells in the premotor cortex that fire right before a person reaches for a rock, steps forward, turns away, begins to smile.Amazingly, the same neurons fire whether we do something or watch someone else do the same thing, and both summon similar feelings. Learning form our own mishaps isn't as safe as learning from someone else's, which helps us decipher the world of intentions, making our social whirl possible. The brain evolved clever ways to spy or eavesdrop on risk, to fathom another's joy or pain quickly, as detailed sensations, without resorting to words. We feel what we see, we experience others as self.

We sleep, allowing gravity to hold us, allowing Earth- our larger body- to recalibrate our neurons, composting the keen encounters of our waking hours (the tensions and terrors of our individual days), stirring them back, as dreams, into the sleeping substance of our muscles. We give ourselves over to the influence of the breathing earth. Sleep is the shadow of the earth as it seeps into our skin and spreads throughout our limbs, dissolving our individual will into the thousand and one selves that compose it- cells, tissues, and organs taking their prime directives now from gravity and the wind- as residual bits of sunlight, caught in the long tangle of nerves, wander the drifting landscape of our earth-borne bodies like deer moving across the forested valleys.

At this moment, in this place, the shifting action potential in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high-precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up the optic nerves, cross the chiasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional.

The really amazing thing about all this is no matter what you believe,it took some doing to get from a point where there was nothing, to a point where all the right neurons fire and pop so that we can make decisions. More amazing is how even though that's become second nature, we all still manage to screw it up.

Have you ever cannonballed into a cold lake? The shock of an old memory is kind of like that; every neuron singing a bright hosanna: here we are. You forgot about us, but we didn’t forget about you.

DON’T LEAD A DOUBLE LIFE. Everything you do takes up space in your brain. If you live a double life (and you know what I mean if I’m talking to you), then that extra life takes up neurons and synapses working overtime. The brain can’t handle it. It starts to degrade instead of grow.

Every age has its signature afflictions. Thus, a bacterial age existed; at the latest, it ended with the discovery of antibiotics. Despite widespread fear of an influenza epidemic, we are not living in a viral age. Thanks to immunological technology, we have already left it behind. From a pathological standpoint, the incipient twenty-first century is determined neither by bacteria nor by viruses, but by neurons. Neurological illnesses such as depression, attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), and burnout syndrome mark the landscape of pathology at the beginning of the twenty-first century.

Our choices—the natural consequences of our thoughts and imagination—get “under the skin” of our DNA and can turn certain genes on and off, changing the structure of the neurons in our brains. So our thoughts, imagination, and choices can change the structure and function of our brains on every level:

Oh Romina, that’s where you’re wrong. A story can hurt you. A good story can wound, maim, and scar. A good story will leave you questioning what you believe to be right or wrong for the sake of pseudo-pleasure fulfilled by some neurons shooting off sparks in your brain. A good story will tear your soul out from your chest and keep you from moving on until you find another that can take its place.

A study published in the October 22, 2014, issue of the journal Neuron suggests that the brain’s chemistry changes when we become curious, helping us better learn and retain information. But curiosity is uncomfortable because it involves uncertainty and vulnerability.

There is no religion better than love, no color better than the color of happiness and no language better than the language of compassion.

Willpower is more than just a metaphor; self-control is a finite resource. Frontal neurons are expensive cells, and expensive cells are vulnerable cells. Consistent

Whenever we use our brain, we fire certain neuronal connections, and the more these connections get used, the stronger they become.

I'm more than a few neurons shy of a synapse right now, and it feels absolutely fan-fucking-tastic.

You can think about this decoupling as the converse of neurons that fire together wire together. Here, neurons out of sync fail to link.

WHEN THE BODY is rendered useless, the mind still runs like a bloodhound along well-worn trails of neurons, tracking the echoing questions: the confused family of whys, whats, and whens and their impossibly distant kin how. The search is exhaustive; the answers, elusive.

It is difficult to overstate the importance of understanding mirror neurons and their function. They may well be central to social learning, imitation, and the cultural transmission of skills and attitudes—perhaps even of the pressed-together sound clusters we call words. By hyperdeveloping the mirror-neuron system, evolution in effect turned culture into the new genome. Armed with culture, humans could adapt to hostile new environments and figure out how to exploit formerly inaccessible or poisonous food sources in just one or two generations—instead of the hundreds or thousands of generations such adaptations would have taken to accomplish through genetic evolution. Thus culture became a significant new source of evolutionary pressure, which helped select brains that had even better mirror-neuron systems and the imitative learning associated with them. The result was one of the many self-amplifying snowball effects that culminated in Homo sapiens, the ape that looked into its own mind and saw the whole cosmos reflected inside.

In an extreme view, the world can be seen as only connections, nothing else. We think of a dictionary as the repository of meaning, but it defines words only in terms of other words. I liked the idea that a piece of information is really defined only by what it's related to, and how it's related. There really is little else to meaning. The structure is everything. There are billions of neurons in our brains, but what are neurons? Just cells. The brain has no knowledge until connections are made between neurons. All that we know, all that we are, comes from the way our neurons are connected.

And what science had revealed was this: Prior to treatment, patients diagnosed with schizophrenia, depression, and other psychiatric disorders do not suffer from any known "chemical imbalance". However, once a person is put on a psychiatric medication, which, in one manner or another, throws a wrench into the usual mechanics of a neuronal pathway, his or her brain begins to function, as Hyman observed, abnormally.

There are millions of neurons in the brain. Humming Om chanting create resonance patterns between different brain regions that foster subsequent long-term plasticity changes in the brain.

It was not a haunting. It was possession and not even that, but something she couldn’t even begin to describe. The creation of an afterlife, furnished with the marrow and the bones and the neurons of a woman, made of stems and spores.

Then let me tell you something instead. When they make an Envoy, do you want to know what they do? They burn out every evolved violence limitation instinct in the human psyche. Submission signal recognition, pecking-order dynamics, pack loyalties. It all goes, tuned out a neuron at a time; and they replace it with a conscious will to harm.” He stared back at me in silence. “Do you understand me? It would have been easier to kill you just then. It would have been easier. I had to stop myself. That’s what an Envoy is, Curtis. A reassembled human. An artifice.

Joy and serenity are not slavishly tied to our physiology. We are not programmed neurons over which we have no control. We are collaborators in the generation of our thoughts and emotions.

Random search can be more efficient than nonrandom search—something that Good and Turing had discovered at Bletchley Park. A random network, whether of neurons, computers, words, or ideas, contains solutions, waiting to be discovered, to problems that need not be explicitly defined.

Mr. L. did not get better all at once. He had first to experience cycles of separations, dreams, depressions, and insights—the repetition, or 'working through,' required for long-term neuroplastic change. New ways of relating had to be learned, wiring new neurons together, and old ways of responding had to be unlearned, weakening neuronal links. Because Mr. L. had linked the ideas of separation and death, they were wired together in his neuronal networks. Now that he was conscious of his association, he could unlearn it.

Some researchers have proposed that experiencing empathy and compassion through the mirror neuron system is equivalent to having compassion for yourself. Thus, “giving is receiving ” is a brain-based truth. Insensitivity and selfishness are essentially bad for your brain and your mental health. In contrast, compassion and loving relationships are good for your brain and your mental health.

The revolution is built on three simple facts. (1) Every human movement, thought, or feeling is a precisely timed electric signal traveling through a chain of neurons—a circuit of nerve fibers. (2) Myelin is the insulation that wraps these nerve fibers and increases signal strength, speed, and accuracy. (3) The more we fire a particular circuit, the more myelin optimizes that circuit, and the stronger, faster, and more fluent our movements and thoughts become.

We use objects to navigate spaces, making a map in our heads as neurons fire, pathways so well-worn we don’t even know we reference them as we move from one location to the next, the same pattern. Every day.

He always reminded us that every atom in our bodies was once part of a distant star that had exploded. He talked about how evolution moves from simplicity toward complexity, and how human intelligence is the highest known expression of evolution. I remember him telling me that a frog's brain is much more complex than a star. He saw human consciousness as the first neuron of the universe coming to life and awareness. A spark in the darkness, waiting to spread to fire.

In fact, the belief that neurophysiology is even relevant to the functioning of the mind is just hypothesis. Who knows if we're looking at the right aspects of the brain at all. Maybe there are other aspects of the brain that nobody has even dreamt of looking at yet. That's often happened in the history of science. When people say that the mental is the neurophysiological at a higher level, they're being radically unscientific. We know a lot about the mental from a scientific point of view. We have explanatory theories that account for a lot of things. The belief that neurophysiology is implicated in these things could be true, but we have every little evidence for it. So, it's just a kind of hope; look around and you see neurons; maybe they're implicated.

He was not above calling a book unreadable. But their literary merit wasn’t important at this moment. They were words strung together to represent the firing of neurons and the transferring of information through synapses. They were human minds set into paper, and Sebastian loved every single one of them, even the ones he found disposable.

That wasn’t a true dream, but an ancient organic memory millions of years old. The innate releasing mechanisms laid down in your cytoplasm have been awakened. The expanding sun and rising temperatures are driving you back down to the spinal levels into the drowned seas of the lowest layers of your unconscious, into the entirely new zone of the neuronic psyche. This is the lumbar transfer, total psychic recall. We really remember these swamps and lagoons.

If you want to see philosophy in action, pay a visit to a robo-rat laboratory. A robo-rat is a run-ofthe-mill rat with a twist: scientists have implanted electrodes into the sensory and reward areas in the rat’s brain. This enables the scientists to manoeuvre the rat by remote control. After short training sessions, researchers have managed not only to make the rats turn left or right, but also to climb ladders, sniff around garbage piles, and do things that rats normally dislike, such as jumping from great heights. Armies and corporations show keen interest in the robo-rats, hoping they could prove useful in many tasks and situations. For example, robo-rats could help detect survivors trapped under collapsed buildings, locate bombs and booby traps, and map underground tunnels and caves. Animal-welfare activists have voiced concern about the suffering such experiments inflict on the rats. Professor Sanjiv Talwar of the State University of New York, one of the leading robo-rat researchers, has dismissed these concerns, arguing that the rats actually enjoy the experiments. After all, explains Talwar, the rats ‘work for pleasure’ and when the electrodes stimulate the reward centre in their brain, ‘the rat feels Nirvana’. To the best of our understanding, the rat doesn’t feel that somebody else controls her, and she doesn’t feel that she is being coerced to do something against her will. When Professor Talwar presses the remote control, the rat wants to move to the left, which is why she moves to the left. When the professor presses another switch, the rat wants to climb a ladder, which is why she climbs the ladder. After all, the rat’s desires are nothing but a pattern of firing neurons. What does it matter whether the neurons are firing because they are stimulated by other neurons, or because they are stimulated by transplanted electrodes connected to Professor Talwar’s remote control? If you asked the rat about it, she might well have told you, ‘Sure I have free will! Look, I want to turn left – and I turn left. I want to climb a ladder – and I climb a ladder. Doesn’t that prove that I have free will?

Our brains contain one hundred billion nerve cells (neurons). Each neuron makes links with ten thousand other neurons to form an incredible three dimensional grid. This grid therefore contains a thousand trillion connections - that's 1,000,000,000,000,000 (a quadrillion). It's hard to imagine this, so let's visualise each connection as a disc that's 1mm thick. Stack up the quadrillion discs on top of each other and they will reach the sun (which is ninety-three million miles from the earth) and back, three times over.

Exercise increases many of the neurotransmitters involved in positive mood regulation: dopamine, serotonin, norepinephrine, epinephrine, endocannabinoids, and endogenous opioid peptides (endorphins). Exercise contributes to the birth of new neurons and supporting glial cells. Exercise even reduces the likelihood of using and getting addicted to drugs.

Your brain needs plenty of rest to function at it's optimal level. Go to sleep!

Kandel argues that when psychotherapy changes people, 'it presumably does so through learning, by producing changes in gene expression that alter the strength of synaptic connections, and structural changes that alter the anatomical pattern of interconnections between nerve cells of the brain.' Psychotherapy works by going deep into the brain and its neurons and changing their structure by turning on the right genes. Psychiatrist Dr. Susan Vaughan has argued that the talking cure works by 'talking to neurons,' and that an effective psychotherpist or psychoanalyst is a 'microsurgeon of the mind' who helps patients make needed alterations in neuronal networks.

My mitochondria comprise a very large proportion of me. I cannot do the calculation, but I suppose there is almost as much of them in sheer dry bulk as there is the rest of me. Looked at in this way, I could be taken for a very large, motile colony of respiring bacteria, operating a complex system of nuclei, microtubules, and neurons for the pleasure and sustenance of their families, and running, at the moment, a typewriter.

As the blood poured from his tattered heart into the open air and his brain suffocated, all those incomplete thoughts of Wittgenstein decayed with the dying neurons. Neural connections in the gray matter storing memories and ideas in their ordered configurations fired across the gaps, last gaps of mental life. Thoughts on Truth and Will were erased as flesh sloshed soft and limp against alabaster, no more than rotting human fruit.

Just like we need food and water, humans need each other. A brain study revealed that when placed in an MRI, a patient's reward center lit up when another person sat in the room. Neurons fire when talk to someone, think about someone, and they go haywire when we hold someone's hand. Our brains and bodies are actually programmed to seek each other out and connect. So then why do so many people prefer being alone? Why do we often run for the hills when we feel the slightest connection? Why we do we feel compelled to fight what we're hardwired to do? Maybe it's because when we find someone or something to hold on to, that feeling becomes like air. And we're terrified we're going to lose it. And trust me, you can get pretty good at the alone thing. But most things are better when they're shared with someone else.

I thought if I stared a little longer I could see right inside his head, to his brain, and I don’t know why that turned me on so much. I wanted to witness the workings of his mind, the firing synapses, information traveling safely inside neurons to different parts of his body. A few made it to his hand, and they must have told him to keep holding mine because he didn’t let go.

I don’t like this world. I definitely do not like it. The society in which I live disgusts me; advertising sickens me; computers make me puke. My entire work as a computer expert consists of adding to the data, the cross-referencing, the criteria of rational decision-making. It has no meaning. To tell the truth, it is even negative up to a point; a useless encumbering of the neurons. This world has need of many things, bar more information.

What molds our brain? Experience. Even into old age, our experiences actually change the physical structure of the brain. When we undergo an experience, our brain cells—called neurons—become active, or “fire.” The brain has one hundred billion neurons, each with an average of ten thousand connections to other neurons.

It [the mind] can make a heaven of hell or a hell of heaven.” In our constant search for meaning in this baffling and temporary existence, trapped as we are within our three pounds of neurons, it is sometimes hard to tell what is real. We often invent what isn’t there. Or ignore what is. We try to impose order, both in our minds and in our conceptions of external reality. We try to connect. We try to find truth. We dream and we hope. And underneath all of these strivings, we are haunted by the suspicion that what we see and understand of the world is only a tiny piece of the whole.

Examples of fractals are everywhere in nature. They can be found in the patterns of trees, branches, and ferns, in which each part appears to be a smaller image of the whole. They are found in the branch-like patterns of river systems, lightning, and blood vessels. They can be seen in snowflakes, seashells, crystals, and mountain ranges. We can even see the holographic and fractal-like nature of reality in the structure of the Universe itself, as the clusters of galaxies and dark matter resemble the neurons in our brain, the mycelium network of fungi, as well as the network of the man-made Internet.

We have a hundred billion neurons in our brains, as many as there are stars in a galaxy, with an even more astronomical number of links and potential combinations through which they can interact. We are not conscious of all of this. “We” are the process formed by this entire intricacy, not just by the little of it of which we are conscious.

To live for your children seems a normal thing, a respectable one; to live because of your children is something else. Mine are the blood of me, and the oxygen in that blood, the airflow and the neurons firing and the stretch and release of muscles in limbs, they are the foundations that make up my skeleton, all the collagen and calcium upon which I stand and fall, and the pulse and the flow and the beat. But I think maybe this is too much for them to be. The breath of a man. The life of him. I think it is too heavy a thing for children to carry.

Whales have a highly evolved language that works like sonar. They have special neurons called spindle cells. Human have them, too, and they’re linked with self-awareness, and compassion, and language. Except whales have had them about fifteen million years longer than we have.

It might not be immediately obvious to some readers why the ability to perform 10^85 computational operations is a big deal. So it's useful to put it in context. [I]t may take about 10^31-10^44 operations to simulate all neuronal operations that have occurred in the history of life on Earth. Alternatively, let us suppose that the computers are used to run human whole brain emulations that live rich and happy lives while interacting with one another in virtual environments. A typical estimate of the computational requirements for running one emulation is 10^18 operations per second. To run an emulation for 100 subjective years would then require some 10^27 operations. This would be mean that at least 10^58 human lives could be created in emulation even with quite conservative assumptions about the efficiency of computronium. In other words, assuming that the observable universe is void of extraterrestrial civilizations, then what hangs in the balance is at least 10,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 human lives. If we represent all the happiness experienced during one entire such life with a single teardrop of joy, then the happiness of these souls could fill and refill the Earth's oceans every second, and keep doing so for a hundred billion billion millennia. It is really important that we make sure these truly are tears of joy.

What if you don't believe that you love yourself?  Doesn't matter.  Your role is to lay down the pathways, brick upon brick, reinforce the connections between the neurons.  The mind already has a strong wiring for love.  The body knows it as well.  It knows that love nurtures, that love is gentle, that love is accepting.  It knows that love heals.

Inspirations sleet through the universe continuously. Their destination, as if they cared, is the right mind in the right place at the right time. They hit the right neuron, there's a chain reaction, and a little while later someone is blinking furiously in the TV lights and wondering how the hell he came up with the idea of pre-sliced bread in the first place. Leonard of Quirm knew about inspirations. One of his earliest inventions was an earthed metal nightcap, worn in the hope that the damned things would stop leaving their white-hot trails across his tortured imagination. It seldom worked. He knew the shame of waking up to find the sheets covered with nocturnal sketches of seige engines for apple-peeling machines.

Individuality is deeply imbued in us from the very start, at the neuronal level. Even at a motor level, researchers have shown, an infant does not follow a set pattern of learning to walk or how to reach for something. Each baby experiments with different ways of reaching for objects and over the course of several months discovers or selects his own motor solutions. When we try to envisage the neural basis of such individual learning, we might imagine a "population" of movements (and their neural correlates) being strengthened or pruned away by experience. Similar considerations arise with regard to recover and rehabilitation after strokes and other injuries. There are no rules; there is no prescribed path of recovery; every patient must discover or create his own motor and perceptual patterns, his own solutions to the challenges that face him; and it is the function of a sensitive therapist to help him in this. And in its broadest sense, neural Darwinism implies that we are destined, whether we wish it or not, to a life of particularity and self-development, to make our own individual paths through life.

The brain is its own galaxy, with more cells than stars in the Milky Way. The most powerful organ in the body, it rivals any supercomputer, processing 90,000 to 150,000 thoughts a day through billions of neurons and trillions of synaptic connections. Now that we have found a pathway to retrieving memories that before were inaccessible, we are perfecting its function too quickly.

Destiny is no more than the fulfillment of purposive potentialities within us. The human cerebral cortex is a single sheet composed of more neurons than there are stars in the known universe folded like a paper crane to fit in a quart-sized cubbyhole; there is enough potential energy in a single person that if released would equal thirty hydrogen bombs. Destiny is nothing to sneeze at!

Through mirror neurons and resonance circuitry, we are taking in each other's bodily state, feelings and intention in each emerging moment (Iacoboni, 2009). This gives us an approximate empathic sense of what is happening in the other person, but it is important to be aware that the information is also being filtered through our implicit lens. This filtering colors our perceptions and pretty much guarantees there will be ruptures that invite repairs, as our offers of empathy will sometimes not reflect what the other person is experiencing.

Every unique thing in nature is related to the whole, and partakes of the perfection of the whole. Each particle is a microcosm, and faithfully renders the likeness of the world. In geometric harmony of the cosmos there are ways that resemble, there are universal patterns, from blood vessels, to winter trees or to a river delta, from nautilus shell to spiral galaxy, from neurons in the brain to the cosmic web. A whole universe of connections is in your mind – a universe within a universe – and one capable of reaching out to the other that gave rise to it. Billions of neurons touching billions of stars – surely spiritual.

Christ attained the ultimate spiritual oneness through prayer and devotion, Moses and Mohammed through prayer, Buddha and all the Indian sages through intense meditation and so did I. And so can you.

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.” Helena leans forward, snaps her fingers. “Just what your brain does to interpret a simple stimulus like that is incredible. The visual and auditory information arrive at your eyes and ears at different speeds, and then are processed by your brain at different speeds. Your brain waits for the slowest bit of stimulus to be processed, then reorders the neural inputs correctly, and lets you experience them together, as a simultaneous event—about half a second after what actually happened. We think we’re perceiving the world directly and immediately, but everything we experience is this carefully edited, tape-delayed reconstruction.

Consider an AI that has hedonism as its final goal, and which would therefore like to tile the universe with “hedonium” (matter organized in a configuration that is optimal for the generation of pleasurable experience). To this end, the AI might produce computronium (matter organized in a configuration that is optimal for computation) and use it to implement digital minds in states of euphoria. In order to maximize efficiency, the AI omits from the implementation any mental faculties that are not essential for the experience of pleasure, and exploits any computational shortcuts that according to its definition of pleasure do not vitiate the generation of pleasure. For instance, the AI might confine its simulation to reward circuitry, eliding faculties such as a memory, sensory perception, executive function, and language; it might simulate minds at a relatively coarse-grained level of functionality, omitting lower-level neuronal processes; it might replace commonly repeated computations with calls to a lookup table; or it might put in place some arrangement whereby multiple minds would share most parts of their underlying computational machinery (their “supervenience bases” in philosophical parlance). Such tricks could greatly increase the quantity of pleasure producible with a given amount of resources.

A lizard never thinks something is wrong with the world, even as it watches its young get eaten alive. It doesn't tell itself "something is wrong with the world," because it doesn't have enough neurons to imagine the world being other than what it is. It doesn't expect a world in which there is no predators, so it doesn't condemn the world for falling short of expectations. it doesn't condemn itself for failing to keep its offspring alive. Humans expect more, and we do something about it. That's why we end up focused on our disappointments instead of saluting our accomplishments.

Sebastian ran a finger over the spines of the books on the shelf. It did not matter to him what the titles were. They were books. They were filled with thoughts. Their relevance was debatable; he was sure some were exceptional while others were the works of lesser minds. He was not above calling a book unreadable. But their literary merit wasn’t important at this moment. They were words strung together to represent the firing of neurons and the transferring of information through synapses. They were human minds set into paper, and Sebastian loved every single one of them, even the ones he found disposable.

Mirror-touch synesthesia could very well scientifically explain why physical empaths seem to “catch” or absorb the illnesses of other people, and also why empaths, as a whole, find violence absolutely unbearable to watch.

Criticisms of a society filled with fools have no power in them to bother the sage that has emerged from the agonizing fire of misery.

The transcendental state of Absolute Oneness sets the human mind free.

It is in the solitude that legends are born.

There has been more bloodshed in the name of God than for any other cause. And it is all because people never attempt to reach the fountain-head. They are content only to comply with the customs of their forefathers and instructions on some books, and want others to do the same. But, to explain God after merely reading the scriptures is like explaining the city of New York after seeing it only in a map.

It was Freud's ambition to discover the cause of hysteria, the archetypal female neurosis of his time. In his early investigations, he gained the trust and confidence of many women, who revealed their troubles to him.Time after time, Freud's patients, women from prosperous, conventional families, unburdened painful memories of childhood sexual encounters with men they had trusted: family friends, relatives, and fathers. Freud initially believed his patients and recognized the significance of their confessions. In 1896, with the publication of two works, The Aetiology of Hysteria and Studies on Hysteria, he announced that he had solved the mystery of the female neurosis. At the origin of every case of hysteria, Freud asserted, was a childhood sexual trauma. But Freud was never comfortable with this discovery, because of what it implied about the behavior of respectable family men. If his patients' reports were true, incest was not a rare abuse, confined to the poor and the mentally defective, but was endemic to the patriarchal family. Recognizing the implicit challenge to patriarchal values, Freud refused to identify fathers publicly as sexual aggressors. Though in his private correspondence he cited "seduction by the father" as the "essential point" in hysteria, he was never able to bring himself to make this statement in public. Scrupulously honest and courageous in other respects, Freud falsified his incest cases. In The Aetiology of Hysteria, Freud implausibly identified governessss, nurses, maids, and children of both sexes as the offenders. In Studies in Hysteria, he managed to name an uncle as the seducer in two cases. Many years later, Freud acknowledged that the "uncles" who had molested Rosaslia and Katharina were in fact their fathers. Though he had shown little reluctance to shock prudish sensibilities in other matters, Freud claimed that "discretion" had led him to suppress this essential information. Even though Freud had gone to such lengths to avoid publicly inculpating fathers, he remained so distressed by his seduction theory that within a year he repudiated it entirely. He concluded that his patients' numerous reports of sexual abuse were untrue. This conclusion was based not on any new evidence from patients, but rather on Freud's own growing unwillingness to believe that licentious behavior on the part of fathers could be so widespread. His correspondence of the period revealed that he was particularly troubled by awareness of his own incestuous wishes toward his daughter, and by suspicions of his father, who had died recently. p9-10

Harmony doesn’t come merely through tolerance. You don’t need to tolerate people from other cultural backgrounds. It is time you start loving them. Toleration may make you a decent person, but it is love that makes you a true human being.

As graduation loomed, I had a nagging sense that there was still far too much unresolved for me, that I wasn’t done studying. I applied for a master’s in English literature at Stanford and was accepted into the program. I had come to see language as an almost supernatural force, existing between people, bringing our brains, shielded in centimeter-thick skulls, into communion. A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans—i.e., “human relationality”—that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced—of passion, of hunger, of love—bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

Freud wrote about it a century ago. How we rummage through the armory of the past to retrieve the weapons needed to repeat, repeat, repeat past traumas. He said it was primitive, instinctual, destructive. Like a demon inside us all. And now we know it's true. The brain itself is built with the battered beams of our early years. What the conscious mind forgets, the neurons remember.

Although neuroplasticity provides an escape from genetic determinism, a loophole for free thought and free will, it also imposes its own form of determinism on our behavior. As particular circuits in our brain strengthen through the repetition of a physical or mental activity, they begin to transform that activity into a habit. The paradox of neuroplasticity, observes Doidge, is that, for all the mental flexibility it grants us, it can end up locking us into “rigid behaviors.”33 The chemically triggered synapses that link our neurons program us, in effect, to want to keep exercising the circuits they’ve formed. Once we’ve wired new circuitry in our brain, Doidge writes, “we long to keep it activated.

Humans have always exalted dreams. Pindar of Thebes, the Greek lyric poet, suggested that the soul is more active while dreaming than while awake. He believed that during a dream, the awakened soul may see the future, “an award of joy or sorrow drawing near.” So it’s no wonder that humans were quick to reserve dreams for people alone; researchers for many years claimed dreams were a property of “higher” minds. But any pet owner who has heard her dog woof or seen his cat twitch during sleep knows that is not true. MIT researchers now know not only that rats dream, but what they dream about. Neurons in the brain fire in distinctive patterns while a rat in a maze performs particular tasks. The researchers repeatedly saw the exact same patterns reproduced while the rats slept—so clearly that they could tell what point in the maze the rat was dreaming about, and whether the animal was running or walking in the dream. The rats’ dreams took place in an area of the brain known to be involved with memory, further supporting a notion that one function of dreams is to help an animal remember what it has learned.

Nature programmed the neurobiological processes of early love to appear as something beyond the primitive sexual cravings of the genitals. So, from an evolutionary standpoint, it all leads to copulation and reproduction, but from the perspective of the individual who has recently fallen head over heels in love with someone, it is mostly about a sensation of warmth and delight, and rarely of sexual nature.

Research2 shows that older people who remain physically active throughout old age have more proteins in the brain that keep the connections between the neurons strong and healthy. This correlates to higher cognitive function and less neurodegeneration. The brain is a remarkable piece of machinery that we can programme and continue to upgrade so that we can live a full life that’s governed by autonomy and control.

So who you are at any given moment depends on the detailed rhythms of your neuronal firing. During the day, the conscious you emerges from that integrated neural complexity. At night, when the interaction of your neurons changes just a bit, you disappear. Your loved ones have to wait until the next morning, when your neurons let the wave die and work themselves back into their complex rhythm. Only then do you return.

A cell has a nucleus and some other parts like membranes, plasmas and other stuff. Its energy is made up of protons, neurons and electrons. Genetic scientists, however, have discovered that the majority of a cell is made up of something unknown. Something akin to space filled with electromagnetic fibers of light. The human body is made up of some 37 trillion cells. What do you think you are made of? Who do you think you are?

Neurons that fire together, wire together,’ meaning that activities that repeatedly activate a constellation of neurons cause those neurons to connect more closely, so if a child goes through puberty doing archery, or painting, or video games, or social media. It will cause lasting structural changes in the brain, especially if the activity is rewarding. This is how cultural experience changes the brain, producing a young adult who feels American instead of Japanese, or what is habitually in discover mode as opposed to defend mode.

Before the first step, before the first muscle twitches, before the first neuron fires, there comes a choice: stand still or move. You choose the right option. Then you repeat that choice one hundred thousand times. You don’t run thirty miles, you run a single step many times over. That’s all running is; that’s all anything is. If there’s somewhere you need to be, somewhere you need to get to, or if you need to change or move away from where or what you are, then that’s all it takes. A hundred thousand simple decisions, each one made correctly. You don’t have to think about the distance or the destination or about how far you’ve come or how far you have to go. You just have to think about what’s in front of you and how you’re going to move it behind you.

Just like love becomes consummated upon the attainment of orgasm, all the faith and divinity in the world reach their ultimate existential potential upon the attainment of Absolute Unitary Qualia or simply Absolute Godliness.

The pattern recognition theory of mind that I articulate in this book is based on a different fundamental unit: not the neuron itself, but rather an assembly of neurons, which I estimate to number around a hundred. The wiring and synaptic strengths within each unit are relatively stable and determined genetically—that is the organization within each pattern recognition module is determined by genetic design. Learning takes place in the creation of connections between these units, not within them, and probably in the synaptic strengths of the interunit connections.

Our brain is a circuit board with neurons and terminals ready to be wired. We are born free, then programmed to obey our parents, to tell the truth, pass exams, pursue and achieve, love and propagate, age and fade unfulfilled and uncertain what it has all been for. We swallow the operating system with our mother's milk and sleepwalk into the forest of consumer illusion craving shoes, houses, cars, magazines, experiences that endorse our preconceived dreams and opinions. We grow into our parents. We becomes clones, robots, matchstick men thinking and saying the same, feeling the same, behaving the same, appreciating in books and films and art shows those things we already recognize and understand.

A solitary ant, afield, cannot be considered to have much of anything on his mind; indeed, with only a few neurons strung together by fibers, he can’t be imagined to have a mind at all, much less a thought. He is more like a ganglion on legs. Four ants together, or ten, encircling a dead moth on a path, begin to look more like an idea. They fumble and shove, gradually moving the food toward the Hill, but as though by blind chance. It is only when you watch the dense mass of thousands of ants, crowded together around the Hill, blackening the ground, that you begin to see the whole beast, and now you observe it thinking, planning, calculating. It is an intelligence, a kind of live computer, with crawling bits for its wits.

Having neurons wire together can be a good thing. A positive experience with a math teacher can lead to neural connections that link math with pleasure, accomplishment, and feeling good about yourself as a student. But the opposite is equally true. Negative experiences with a harsh instructor or a timed test and the anxiety that accompanies it can form connections in the brain that create a serious obstacle to the enjoyment not only of math and numbers, but exams and even school in general.

You must hiss at people who intend to undermine your individuality with their false pride and intellectual stupidity. You must frighten them away, lest they should do you harm. Act like you have a lot of venom inside you, but never inject them into anyone.

The growth of the nervous system from beginning to end is dominated by 'a totally integrated matrix, and not a progressive integration of primarily individuated units'. The organism is not a sum of its reflexes, but on the contrary 'the mechanism of the total pattern is an essential component of the performance of the part, i.e. the reflex'. The stimulus-response scheme cannot explain even embryonic behaviour, because movements appear long before the motor neurons of the reflex arc are connected with the sensory neurons. This centrifugal mode of development means that the individual acts on its environment before it reacts to its environment.

Experiencing empathy, the freedom to explore, trust, and insight can reset your default reactions to a more curious, tolerant, and confident stance. Because our brains are plastic, consistently positive experiences do stimulate existing neurons to adapt and connect in different pathways. Nurturing relationships help us grow psychologically and neurally in ways that are not possible in nonnurturing relationships. As adults, our most important opportunity for a nurturing relationship comes through committed partnership. It’s a breakthrough to realize that the purpose of committed relationship is not to be happy, but to heal. And then you will be happy!

First, contrary to popular belief, Buddhists can actually be very anxious people. That’s often why they become Buddhists in the first place. Buddhism was made for the anxious like Christianity was made for the downtrodden or AA for the addicted. Its entire purpose is to foster equanimity, to tame excesses of thought and emotion. The Buddhists have a great term for these excesses. They refer to them as the condition of “monkey mind.” A person in the throes of monkey mind suffers from a consciousness whose constituent parts will not stop bouncing from skull-side to skull-side, which keep flipping and jumping and flinging feces at the walls and swinging from loose neurons like howlers from vines. Buddhist practices are designed explicitly to collar these monkeys of the mind and bring them down to earth—to pacify them. Is it any wonder that Buddhism has had such tremendous success in the bastions of American nervousness, on the West Coast and in the New York metro area?

You are surrounded by ignorance, savagery and fanaticism. You live in a society where everyone thinks he/she knows about everything in the whole universe. If you find yourself among those intellectual idiots, then being good and humble may give rise to doubts in your mind about your own ideas. So, you must first learn to distinguish between real and shallow intellect. Then, as a self- preservation tactic, you need to let your pretence of arrogance grow as big as a Dinosaur, so that the fake intellectuals start to realize their true inferiority in front of you.

When I change I change fast. The moon drags the whatever-it-is up from the earth and it goes through me with crazy wriggling impatience. I picture it as an electrical discharge, entering at my soles and racing upwards in haywire detonations that shock the bones and explode the neurons. The magic's dark red, violent, compressed. I get random flashes of mundane memory-- pushing a shopping cart around Met Foods; opening my apartment window; standing on a subway platform; saying to someone, No, that's carbohydrates in the evenings-- intercut with images of the kills; a white male body on an oil-stained warehouse floor; a solitary trailer with a storm lamp burning; a female thigh releasing a dark arc of blood; my clawed hand scooping out a still-hot heart. This is the Curse's neatest trick: one type of memory doesn't destroy the other. It's still you. It's still all you. You wouldn't think you were built to bear such opposites, but you are. You'd think the system would crash, but it doesn't.

And although he hadn’t fretted over whether his life was worthwhile, he had always wondered why he, why so many others, went on living at all; it had been difficult to convince himself at times, and yet so many people, so many millions, billions of people, lived in misery he couldn’t fathom, with deprivations and illnesses that were obscene in their extremity. And yet on and on and on they went. So was the determination to keep living not a choice at all, but an evolutionary implementation? Was there something in the mind itself, a constellation of neurons as toughened and scarred as tendon, that prevented humans from doing what logic so often argued they should? And yet that instinct wasn’t infallible—he had overcome it once. But what had happened to it after? Had it weakened, or become more resilient? Was his life even his to choose to live any longer?

I had come to see language as an almost supernatural force, existing between people, bringing our brains, shielded in centimeter-thick skulls, into communion. A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans — i.e., “human relationality” — that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced — of passion, of hunger, of love — bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

I like the term “stretch” for describing what deliberate practice feels like, as it matches my own experience with the activity. When I’m learning a new mathematical technique—a classic case of deliberate practice—the uncomfortable sensation in my head is best approximated as a physical strain, as if my neurons are physically re-forming into new configurations. As any mathematician will admit, this stretching feels much different than applying a technique you’ve already mastered, which can be quite enjoyable. But this stretching, as any mathematician will also admit, is the precondition to getting better.

Have you ever looked at a map of our country, Necdet?’ Green Headscarf says. ‘It’s a map of the human mind. We’re split by water over two continents, Europe and Anatolia. We are seven per cent Europe, ninety-three per cent Asia. Conscious Thrace, unconscious, pre-conscious, sub-concious Anatolia. And Istanbul — have you ever seen a neuron, Necdet? A brain cell? The marvel is that the synapses don’t touch. There is always a gap — there must a gap, otherwise consciousness would not exist. The Bosphorus is that synaptic cleft. Potential can flow across the cleft. It’s the cleft that makes consciousness possible.

The experience of being born into a loving household or a stressed and abusive one would actually affect how my brain matured and the types of connections that were made between my neurons. It is not just my ‘values’ that would be shaped in a certain way by my relationships with others (e.g. my parents), but my actual brain, from where my thoughts, feelings and desires flow, is sculpted by my relationships.1 If I’d been unlucky enough to have been born into, say, an old-style orphanage where infants were left in cots all day and there was little care or interaction, then all the potential that lies inside me, which could have been sculpted by love and kindness feeding my brain, would simply have withered away. I would have suffered intellectual losses and decline.

The whole idea of a unified universe with mathematically regular laws, that was what had been flushed down the toilet; the whole notion of physics. Three thousand years of resolving big complicated things into smaller pieces, discovering that the music of the planets was the same tune as a falling apple, finding that the true laws were perfectly universal and had no exceptions anywhere and took the form of simple maths governing the smallest parts, not to mention that the mind was the brain and the brain was made of neurons, a brain was what a person was - And then a woman turned into a cat, so much for all that.

Lithium regulates the proteins that control the body’s inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people’s DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls—at which point the brain should “notice” the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don’t realize they should stop revving. Lithium helps cleave the proteins from DNA so people can wind down. Notice that sunlight still trumps lithium during the day and resets the proteins; it’s only when the sunlight goes away at night that lithium helps DNA shake free. Far from being sunshine in a pill, then, lithium acts as “anti-sunlight.” Neurologically, it undoes sunlight and thereby compresses the circadian clock back to twenty-four hours—preventing both the mania bubble from forming and the Black Tuesday crash into depression.

Each electrical pulse—and resulting squirt of neurotransmitter—is not an order commanding the next neuron’s actions; it is more like a vote on what the next neuron should do. The whole pattern of activity is like a presidential election. Everyone votes on who the president should be, and depending on those votes, the country veers off in one direction or another. If you can change the number of votes in a few key swing states by only a few percentage points, you can dramatically change the course of the country. The same is true of the brain. By changing the firing rate of neurons in a few key regions, you can influence the pattern of activity in the entire brain.

power dynamic operates in emotional contagion, determining which person’s brain will more forcefully draw the other into its emotional orbit. Mirror neurons are leadership tools: Emotions flow with special strength from the more socially dominant person to the less. One reason is that people in any group naturally pay more attention to and place more significance on what the most powerful person in that group says and does. That amplifies the force of whatever emotional message the leader may be sending, making her emotions particularly contagious. As I heard the head of a small organization say rather ruefully, “When my mind is full of anger, other people catch it like the flu.

When we learn, we alter which genes in our neurons are “expressed,” or turned on. Our genes have two functions. The first, the “template function,” allows our genes to replicate, making copies of themselves that are passed from generation to generation. The template function is beyond our control. The second is the “transcription function.” Each cell in our body contains all our genes, but not all those genes are turned on, or expressed. When a gene is turned on, it makes a new protein that alters the structure and function of the cell. This is called the transcription function because when the gene is turned on, information about how to make these proteins is “transcribed” or read from the individual gene. This transcription function is influenced by what we do and think. Most people assume that our genes shape us—our behavior and our brain anatomy. Kandel’s work shows that when we learn our minds also, affect which genes in our neurons are transcribed. Thus we can shape our genes, which in turn shape our brain’s microscopic anatomy.

Where, then, is any particular gene—say, the gene for long legs in humans? This is a little like asking where is Beethoven’s Piano Sonata in E minor. Is it in the original handwritten score? The printed sheet music? Any one performance—or perhaps the sum of all performances, historical and potential, real and imagined? The quavers and crotchets inked on paper are not the music. Music is not a series of pressure waves sounding through the air; nor grooves etched in vinyl or pits burned in CDs; nor even the neuronal symphonies stirred up in the brain of the listener. The music is the information. Likewise, the base pairs of DNA are not genes. They encode genes. Genes themselves are made of bits.

I encouraged my patients to floss. It was hard to do some days. They should have flossed. Flossing prevents periodontal disease and can extend life up to seven years. It’s also time consuming and a general pain in the ass. That’s not the dentist talking. That’s the guy who comes home, four or five drinks in him, what a great evening, ha-has all around, and, the minute he takes up the floss, says to himself, What’s the point? In the end, the heart stops, the cells die, the neurons go dark, bacteria consumes the pancreas, flies lay their eggs, beetles chew through tendons and ligaments, the skin turns to cottage cheese, the bones dissolve, and the teeth float away with the tide. But then someone who never flossed a day in his life would come in, the picture of inconceivable self-neglect and unnecessary pain— rotted teeth, swollen gums, a live wire of infection running from enamel to nerve— and what I called hope, what I called courage, above all what I called defiance, again rose up in me, and I would go around the next day or two saying to all my patients, “You must floss, please floss, flossing makes all the difference.

mental activity such as directing attention, actually shape the structure of the brain?” As we’ve seen, experience means neural firing. When neurons fire together, the genes in their nuclei—their master control centers—become activated and “express” themselves. Gene expression means that certain proteins are produced. These proteins then enable the synaptic linkages to be constructed anew or to be strengthened. Experience also stimulates the production of myelin, the fatty sheath around axons, resulting in as much as a hundredfold increase in the speed of conduction down the neuron’s length. And as we now know, experience can also stimulate neural stem cells to differentiate into wholly new neurons in the brain. This neurogenesis, along with synapse formation and myelin growth, can take place in response to experience throughout our lives. As discussed before, the capacity of the brain to change is called neuroplasticity We are now discovering how the careful focus of attention amplifies neuroplasticity by stimulating the release of neurochemicals that enhance the structural growth of synaptic linkages among the activated neurons.

If an answer didn’t come to her during this learning phase, she let the subject settle inside her. She no longer thought about it consciously, allowing instead some dark and muscled lobe of her brain to take over. The issue was broken down into components and absorbed, images from the material occasionally appearing in her thoughts like neuronal burps. Every once in awhile she’d flip through her notes, having no expectations but going through the ritual in order to goose her brain along. After her mind had worked on the problem like this for long enough—a few days, a month, maybe a whole year—the answer would suddenly hit her. The solution glittering and fully realized, as obvious as though someone much smarter had handed it to her, frustrated with how long she was taking.

What to call it - the spark of God? Survival instinct? The souped-up computer of an apex brain evolved from eons in the R&D of natural selection? You could practically see the neurons firing in the kid’s skull. His body was all spring and torque, a bundle of fast-twitch muscles that exuded faint floral whiffs of ripe pear. So much perfection in such a compact little person - Billy had to tackle him from time to time, wrestle him squealing to the ground just to get that little rascal in his hands, just your basic adorable thirty-month-old with big blue eyes clear as chlorine pools and Huggies poking out of his stretchy-waist jeans. So is this what they mean by the sanctity of life? A soft groan escaped Billy when he thought about that, the war revealed in this fresh and gruesome light. Oh. Ugh. Divine spark, image of God, suffer the little children and all that - there’s real power when words attach to actual things. Made him want to sit right down and weep, as powerful as that. He got it, yes he did, and when he came home for good he’d have to meditate on this, but for now it was best to compartmentalize, as they said, or even better not to mentalize at all.

If I look at a forest from afar, I see a dark green velvet. As I move toward it, the velvet breaks up into trunks, branches and leaves: the bark of the trunks, the moss, the insects, the teeming complexity. In every eye of every ladybug, there is an extremely elaborate structure of cells connected to neurons that guide and enable them to live. Every cell is a city, every protein a castle of atoms; in each atomic nucleus an inferno of quantum dynamics is stirring, quarks and gluons swirl, excitations of quantum fields. This is only a small wood on a small planet that revolves around a little star, among one hundred billion stars in one of the thousand billion galaxies constellated with dazzling cosmic events. In every corner of the universe we find vertiginous wells of layers of reality.

This new science of performance argues that you get better at a skill as you develop more myelin around the relevant neurons, allowing the corresponding circuit to fire more effortlessly and effectively. To be great at something is to be well myelinated. This understanding is important because it provides a neurological foundation for why deliberate practice works. By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill. The reason, therefore, why it’s important to focus intensely on the task at hand while avoiding distraction is because this is the only way to isolate the relevant neural circuit enough to trigger useful myelination. By contrast, if you’re trying to learn a complex new skill (say, SQL database management) in a state of low concentration (perhaps you also have your Facebook feed open), you’re firing too many circuits simultaneously and haphazardly to isolate the group of neurons you actually want to strengthen. In

Meditation has also been proven scientifically to untangle and rewire the neurological pathways in the brain that make up the conditioned personality. Buddhist monks, for example, have had their brains scanned by scientists as they sat still in deep altered states of consciousness invoked by transcendental meditation and the scientists were amazed at what they beheld. The frontal lobes of the monks lit up as bright as the sun! They were in states of peace and happiness the scientists had never seen before. Meditation invokes that which is known in neuroscience as neuroplasticity; which is the loosening of the old nerve cells or hardwiring in the brain, to make space for the new to emerge. Meditation, in this sense, is a fire that burns away the old or conditioned self, in the Bhagavad Gita, this is known as the Yajna; “All karma or effects of actions are completely burned away from the liberated being who, free from attachment, with his physical mind enveloped in wisdom (the higher self), performs the true spiritual fire rite.

Case in point: Warnings on cigarette packages can increase a smoker’s urge to light up. A 2009 study found that death warnings trigger stress and fear in smokers—exactly what public health officials hope for. Unfortunately, this anxiety then triggers smokers’ default stress-relief strategy: smoking. Oops. It isn’t logical, but it makes sense based on what we know about how stress influences the brain. Stress triggers cravings and makes dopamine neurons even more excited by any temptation in sight. It doesn’t help that the smoker is—of course—staring at a pack of cigarettes as he reads the warning. So even as a smoker’s brain encodes the words “WARNING: Cigarettes cause cancer” and grapples with awareness of his own mortality, another part of his brain starts screaming, “Don’t worry, smoking a cigarette will make you feel better!

It might weigh little over a kilogram but, taken on its own scale, the brain is unimaginably vast. One cubic millimetre contains between twenty and twenty-five thousand neurons. It has eighty-six billion of these cells, and each one is complex as a city and is in contact with ten thousand other neurons just like it. Within just one cubic centimetre of brain tissue, there is the same number of connections as there are stars in the Milky Way. Your brain contains a hundred trillion of them. Information in the form of electricity and chemicals flows around these paths in great forking trails and in circuits and feedback loops and fantastical storms of activity tat bloom to life speeds of up to a hundred and twenty metres per second. According to the neuroscientist V. S. Ramachandran, 'The number of permutations and combinations of activity that are theoretically possible exceeds the number of elementary particles in the universe.' And yet, he continues, 'We know so little about it that even a child's questions should be seriously entertained.

we can never really experience what other people are experiencing. We always remain on the outside looking in, and this is the cause of so many misunderstandings and conflicts. But the primal source of human intelligence comes from the development of mirror neurons (see here), which gives us the ability to place ourselves in the skin of another and imagine their experience. Through continual exposure to people and by attempting to think inside them we can gain an increasing sense of their perspective, but this requires effort on our part. Our natural tendency is to project onto other people our own beliefs and value systems, in ways in which we are not even aware. When it comes to studying another culture, it is only through the use of our empathic powers and by participating in their lives that we can begin to overcome these natural projections and arrive at the reality of their experience.

Imagine, Bishop, that you have a beloved cat, but that your cat is not with you. If you close your eyes and further imagine you are petting your cat, the same neurons in your brains are activated as if you were petting the actual cat. Our minds may know the difference between its models and reality itself, but it prefers its models. So much so that we apprehend reality through our models, rather than directly via the sense. When I'm speaking to you, I have a little bishop in my head, and though I speak out load, I'm speaking to my little bishop. When you answer, I can only perceive you through my model of you. Mentars also make models, but they don't apprehend reality through them. They end up, not with little people in their minds, but with highly complex rule sets. They relate to their models in the same way we relate to weather models, as things to consult, but not to conflate with external reality.

What is Required by Paul Allen (fragment) 1 All elsewhere being World, how many times have I stood in the bright shadows of a wood, no track or trail leading in, out- as though ground cover renewed as I went through? I sometimes own the moments where I stand alone. Everything else is air and arbitrary firings of neurons we call memory if they happened, fantasy if they didn’t- same pictures. Call it prayer, then, the moments where I’m not aware even of how lovely the moment is- not liking, not disliking- not aware there is a moment until I’m back in the world and remember it- construct it in my mind as having been beautiful. 4 I’m too often bitten by silence. My mother called it dawdling, the ex, brooding. My students call it absent-minded professor. The kindest students bring me back gently. But I live most when silence, shade, and light like this harvest me, a kind of prayer I’m gathered to, not the prayer I clutter with will or words.

... [O]ne of the most influential approaches to thinking about memory in recent years, known as connectionism, has abandoned the idea that a memory is an activated picture of a past event. Connectionist or neural network models are based on the principle that the brain stores engrams by increasing the strength of connections between different neurons that participate in encoding an experience. When we encode an experience, connections between active neurons become stronger, and this specific pattern of brain activity constitutes the engram. Later, as we try to remember the experience, a retrieval cue will induce another pattern of activity in the brain. If this pattern is similar enough to a previously encoded pattern, remembering will occur. The "memory" in a neural network model is not simply an activated engram, however. It is a unique pattern that emerges from the pooled contributions of the cue and the engram. A neural network combines information in the present environment with patterns that have been stored in the past, and the resulting mixture of the two is what the network remembers... When we remember, we complete a pattern with the best match available in memory; we do not shine a spotlight on a stored picture.

The influx of competing messages that we receive whenever we go online not only overloads our working memory; it makes it much harder for our frontal lobes to concentrate our attention on any one thing. The process of memory consolidation can’t even get started. And, thanks once again to the plasticity of our neuronal pathways, the more we use the Web, the more we train our brain to be distracted—to process information very quickly and very efficiently but without sustained attention. That helps explain why many of us find it hard to concentrate even when we’re away from our computers. Our brains become adept at forgetting, inept at remembering. Our growing dependence on the Web’s information stores may in fact be the product of a self-perpetuating, self-amplifying loop. As our use of the Web makes it harder for us to lock information into our biological memory, we’re forced to rely more and more on the Net’s capacious and easily searchable artificial memory, even if it makes us shallower thinkers.

Some could say it is the external world which has molded our thinking-that is, the operation of the human brain-into what is now called logic. Others-philosophers and scientists alike-say that our logical thought (thinking process?) is a creation of the internal workings of the mind as they developed through evolution "independently" of the action of the outside world. Obviously, mathematics is some of both. It seems to be a language both for the description of the external world, and possibly even more so for the analysis of ourselves. In its evolution from a more primitive nervous system, the brain, as an organ with ten or more billion neurons and many more connections between them must have changed and grown as a result of many accidents. The very existence of mathematics is due to the fact that there exist statements or theorems, which are very simple to state but whose proofs demand pages of explanations. Nobody knows why this should be so. The simplicity of many of these statements has both aesthetic value and philosophical interest.

After the war, in the early fifties, when the great break-throughs in science followed one after the other so rapidly, there wasn't time to take stock, to ask the sensible questions. Suddenly there were all these new possibilities laid before us, all these ways to cure so many previously incurable conditions. This was what the world noticed the most, wanted the most. And for a long time, people preferred to believe these organs appeared from nowhere, or at most that they grew in a kind of vacuum. Yes, there were arguments. But by the time people became concerned about . . . about students, by the time they came to consider just how you were reared, whether you should have been brought into existence at all, well by then it was too late. There was no way to reverse the process. How can you ask a world that has come to regard cancer as curable, how can you ask such a world to put away that cure, to go back to the dark days? There was no going back. However uncomfortable people were about your existence, their overwhelming concern was that their own children, their spouses, their parents, their friends, did not die from cancer, motor neurone disease. So for a long time you were kept in the shadows, and people did their best not to think about you. And if they did, they tried to convince themselves you weren't really like us. That you were less than human, so it didn't matter.

Emotional position is part of it, but as an individual you are not your emotions, neither are you your intellect. These are things that you have . They're not things that you are . Therefore you have to start to become aware of the different requirements that human beings have, the different areas that they like to be satisfied in. Which means becoming aware of yourself. I mean, as a writer you're gonna have to understand pretty much the whole universe. But the best place to start is by understanding the inner universe. The entire universe – for one thing – only exists in your perceptions. That's all you're gonna see of it. To all practical intents and purposes this is purely some kind of lightshow that's being put on in the kind of neurons in our brain. The whole of reality. So. To understand the universe there's worse advice than that which was carved above the shrine of the Delphi oracle. Where it just said: “Know thyself”. Understand yourself. Know thyself is a magical goal, but like I say to me there is very little difference between magic and creative art in any sense – the laws of one apply perfectly well to the other.

I hope to inspire you to recognize that your reason for existence is to pursue the things that excite you the most. The best thing you can do--for yourself and everyone else--is to act on the things you're most passionate about. When you do, you'll shine, and everyone else will see that brilliance. On a biological level, the mirror neutrons of the people around you will activate. They will recognize that they can also follow their dreams and accomplish things they have always wanted to accomplish. On a spiritual level, their souls will remember their reason for being.

Our memories are in part reconstructions. Whenever we retrieve a memory, the brain rewrites it a bit, updating the past according to our present concerns and understanding. At the cellular level, LeDoux explains, retrieving a memory means it will be “reconsolidated,” slightly altered chemically by a new protein synthesis that will help store it anew after being updated.40 Thus each time we bring a memory to mind, we adjust its very chemistry: the next time we retrieve it, that memory will come up as we last modified it. The specifics of the new consolidation depend on what we learn as we recall it. If we merely have a flare-up of the same fear, we deepen our fearfulness. But the high road can bring reason to the low. If at the time of the fear we tell ourselves something that eases its grip, then the same memory becomes reencoded with less power over us. Gradually, we can bring the once-feared memory to mind without feeling the rush of distress all over again. In such a case, says LeDoux, the cells in our amygdala reprogram so that we lose the original fear conditioning.41 One goal of therapy, then, can be seen as gradually altering the neurons for learned fear.

The measuring rod, the unit of information, is something called a bit (for binary digit). It is an answer - either yes or no- to an unambiguous question... The information content of the human brain expressed in bits is probably comparable to the total number of connections among the neurons- about a hundred trillion, 10^14 bits. If written out in English, say, that information would fill some twenty million volumes, as many as in the world's largest libraries. The equivalent of twenty million books is inside the heads of every one of us... When our genes could not store all the information necessary for survival, we slowly invented them. But then the time came, perhaps ten thousand years ago, when we needed to stockpile enormous quantities of information outside our bodies. We are the only species on the planet, so far as we know, to have invented a communal memory stored neither in our genes nor in our brains. The warehouse of that memory is called the library... The great libraries of the world contain millions of volumes, the equivalent of about 10^14 bits of information in words, and perhaps 10^15 bits in pictures. This is ten thousand times more than in our brains. If I finish a book a week, I will only read a few thousand books in my lifetime, about a tenth of a percent of the contents of the greatest libraries of our time. The trick is to know which books to read... Books permit us to voyage through time, to tap the wisdom of our ancestors. The library connects us with the insights and knowledge, painfully extracted from Nature, of the greatest minds that ever were, with the best teachers, drawn from the entire planet and from all of our history, to instruct us without tiring, and to inspire us to make our own contribution to the collective knowledge of the human species. Public libraries depend on voluntary contributions. I think the health of our civilization, the depth of our awareness about the underpinnings of our culture and our concern for the future can all be tested by how well we support our libraries. p224-233

It is important to note that the design of an entire brain region is simpler than the design of a single neuron. As discussed earlier, models often get simpler at a higher level—consider an analogy with a computer. We do need to understand the detailed physics ofsemiconductors to model a transistor, and the equations underlying a single real transistor are complex. A digital circuit that multiples two numbers requires hundreds of them. Yet we can model this multiplication circuit very simply with one or two formulas. An entire computer with billions of transistors can be modeled through its instruction set and register description, which can be described on a handful of written pages of text and formulas. The software programs for an operating system, language compilers, and assemblers are reasonably complex, but modeling a particular program—for example, a speech recognition programbased on hierarchical hidden Markov modeling—may likewise be described in only a few pages of equations. Nowhere in such a description would be found the details ofsemiconductor physics or even of computer architecture. A similar observation holds true for the brain. A particular neocortical pattern recognizer that detects a particular invariant visualfeature (such as a face) or that performs a bandpass filtering (restricting input to a specific frequency range) on sound or that evaluates the temporal proximity of two events can be described with far fewer specific details than the actual physics and chemicalrelations controlling the neurotransmitters, ion channels, and other synaptic and dendritic variables involved in the neural processes. Although all of this complexity needs to be carefully considered before advancing to the next higher conceptual level, much of it can be simplified as the operating principles of the brain are revealed.

You want a physicist to speak at your funeral. You want the physicist to talk to your grieving family about the conservation of energy, so they will understand that your energy has not died. You want the physicist to remind your sobbing mother about the first law of thermodynamics; that no energy gets created in the universe, and none is destroyed. You want your mother to know that all your energy, every vibration, every Btu of heat, every wave of every particle that was her beloved child remains with her in this world. You want the physicist to tell your weeping father that amid energies of the cosmos, you gave as good as you got. And at one point you’d hope that the physicist would step down from the pulpit and walk to your brokenhearted spouse there in the pew and tell him that all the photons that ever bounced off your face, all the particles whose paths were interrupted by your smile, by the touch of your hair, hundreds of trillions of particles, have raced off like children, their ways forever changed by you. And as your widow rocks in the arms of a loving family, may the physicist let her know that all the photons that bounced from you were gathered in the particle detectors that are her eyes, that those photons created within her constellations of electromagnetically charged neurons whose energy will go on forever. And the physicist will remind the congregation of how much of all our energy is given off as heat. There may be a few fanning themselves with their programs as he says it. And he will tell them that the warmth that flowed through you in life is still here, still part of all that we are, even as we who mourn continue the heat of our own lives. And you’ll want the physicist to explain to those who loved you that they need not have faith; indeed, they should not have faith. Let them know that they can measure, that scientists have measured precisely the conservation of energy and found it accurate, verifiable and consistent across space and time. You can hope your family will examine the evidence and satisfy themselves that the science is sound and that they’ll be comforted to know your energy’s still around. According to the law of the conservation of energy, not a bit of you is gone; you’re just less orderly. Amen.

But now I speculate re the ants' invisible organ of aggregate thought... if, in a city park of broad reaches, winding paths, roadways, and lakes, you can imagine seeing on a warm and sunny Sunday afternoon the random and unpredictable movement of great numbers of human beings in the same way... if you watch one person, one couple, one family, a child, you can assure yourself of the integrity of the individual will and not be able to divine what the next moment will bring. But when the masses are celebrating a beautiful day in the park in a prescribed circulation of activities, the wider lens of thought reveals nothing errant, nothing inconstant or unnatural to the occasion. And if someone acts in a mutant un-park manner, alarms go off, the unpredictable element, a purse snatcher, a gun wielder, is isolated, surrounded, ejected, carried off as waste. So that while we are individually and privately dyssynchronous, moving in different ways, for different purposes, in different directions, we may at the same time comprise, however blindly, the pulsing communicating cells of an urban over-brain. The intent of this organ is to enjoy an afternoon in the park, as each of us street-grimy urbanites loves to do. In the backs of our minds when we gather for such days, do we know this? How much of our desire to use the park depends on the desires of others to do the same? How much of the idea of a park is in the genetic invitation on nice days to reflect our massive neuromorphology? There is no central control mechanism telling us when and how to use the park. That is up to us. But when we do, our behavior there is reflective, we can see more of who we are because of the open space accorded to us, and it is possible that it takes such open space to realize in simple form the ordinary identity we have as one multicellular culture of thought that is always there, even when, in the comparative blindness of our personal selfhood, we are flowing through the streets at night or riding under them, simultaneously, as synaptic impulses in the metropolitan brain. Is this a stretch? But think of the contingent human mind, how fast it snaps onto the given subject, how easily it is introduced to an idea, an image that it had not dreamt of thinking of a millisecond before... Think of how the first line of a story yokes the mind into a place, a time, in the time it takes to read it. How you can turn on the radio and suddenly be in the news, and hear it and know it as your own mind's possession in the moment's firing of a neuron. How when you hear a familiar song your mind adopts its attitudinal response to life before the end of the first bar. How the opening credits of a movie provide the parameters of your emotional life for its ensuing two hours... How all experience is instantaneous and instantaneously felt, in the nature of ordinary mind-filling revelation. The permeable mind, contingently disposed for invasion, can be totally overrun and occupied by all the characteristics of the world, by everything that is the case, and by the thoughts and propositions of all other minds considering everything that is the case... as instantly and involuntarily as the eye fills with the objects that pass into its line of vision.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

I feel as though dispossessed from the semblances of some crystalline reality to which I’d grown accustomed, and to some degree, had engaged in as a participant, but to which I had, nevertheless, grown inexplicably irrelevant. But the elements of this phenomenon are now quickly dissolving from memory and being replaced by reverse-engineered Random Access actualizations of junk code/DNA consciousness, the retro-coded catalysts of rogue cellular activity. The steel meshing titters musically and in its song, I hear a forgotten tale of the Interstitial gaps that form pinpoint vortexes at which fibers (quanta, as it were) of Reason come to a standstill, like light on the edge of a Singularity. The gaps, along their ridges, seasonally infected by the incidental wildfires in the collective unconscious substrata. Heat flanks passageways down the Interstices. Wildfires cluster—spread down the base trunk Axon in a definitive roar: hitting branches, flaring out to Dendrites to give rise to this release of the very chemical seeds through which sentience is begotten. Float about the ether, gliding a gentle current, before skimming down, to a skip over the surface of a sea of deep black with glimmering waves. And then, come to a stop, still inanimate and naked before any trespass into the Field, with all its layers that serve to veil. Plunge downward into the trenches. Swim backwards, upstream, and down through these spiraling jets of bubbles. Plummet past the threshold to trace the living history of shadows back to their source virus. And acquire this sense that the viruses as a sample, all of the outlying populations withstanding: they have their own sense of self-importance, too. Their own religion. And they mine their hosts barren with the utilitarian wherewithal that can only be expected of beings with self-preservationist motives.