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with L-arginine, L-glutamine, L-ornithine, lysine, glycine, and niacin, all known to increase the body’s internal release of growth hormone. Getting adequate sleep and exercising on a regular basis also stimulate the release of HGH.

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In 1963, Choh Hao Li, chairman and lone tenured faculty member in the Institute of Experimental Biology at Berkeley, announced that he had isolated and purified his sixth pituitary hormone, lipotropin. The magnitude of such a feat is clear considering that only one other person had ever purified a hormone, and that person was not coincidentally a student of Li's. The purification of lipotropin should have been a reason to celebrate; however, Li's colleagues at Berkeley acknowledged but did not rejoice in his success. As they perceived it, endocrinology was a scientific field that came out of the clinical sciences, which meant that Li's research was completely unsound, and they put enormous pressure on him to change his scientific topic. When that did not work, Wendell Stanley tried to 'promote [Li] out of the Virus Laboratory,' then later University Chancellor Clark Kerr threatened to discontinue the Institute for Experimental Biology because it did not fit with Berkeley's commitment to pure research. Things got infinitely worse for Li, of course, because he became perceived as less qualified with each professional achievement. [...] C. H. Li's travails at Berkeley are only half the story. In 1969, five years after transferring from Berkeley to UCSF, Li and his laboratory assistants assembled a highly complex synthetic version of human growth hormone (HGH) that was biologically active and could promote the growth of bones and muscle tissue. Rather than ignore or criticize the work, however, journalists waxed eloquently [sic] about Li's creation of HGH. One described it as no less than a panacea for most of the world's problems. Others clearly saw specific applications: 'it might now be . . . possible to tailor-make hormones that can inhibit breast cancer.' Li's discovery of synthetic HGH 'constituted a truly . . . great research breakthrough [that had] obvious applications,' ranging from 'human growth and development to . . . treatment of cancer and coronary artery disease.' Desperate letters poured in too; athletes wanted to know if HGH would help them become faster, bigger, stronger, and dwarfs from all over the world begged for samples of HGH or to volunteer as experimental subjects. Unlike at Berkeley, Li's discovery made him a hero at UCSF. None other than UCSF Chancellor Phillip Lee described Li's discovery as 'meticulous, painstaking, and brilliant research' and then tried to capitalize on the moment by asking the public and their political representatives to increase federal support of bioscience research. 'Research money is dwindling fast,' repeated Lee to anyone who cared to listen. 'We've proven than synthesis can be done, now all we need is the money and time to prove its tremendous value.' It is not surprising that federal and state money began to pour into Li's lab. What is shocking, however, is how quickly Li achieved scientific acclaim, not because he changed, but because the rest of the world around him changed so much.

HGH was responsible for human growth, and lack of it caused dwarfism, or too much of it caused NBA players.

According to the American College of Cardiology, fasting triggered a 1,300% increase in human growth hormone secretion in women, and an astounding 2,000% increase in men! This statistic alone is a definitive reason to drop what you’re doing and incorporate intermittent fasting into your lifestyle immediately. HGH, commonly known as your fitness hormone, plays a huge role in your health, fitness, and longevity. It actively promotes muscle growth, and even further boosts fat loss by increasing your metabolism. The fact that it simultaneously aids in muscle building and fat loss explains how HGH can help you get lean and lose weight without sacrificing your beneficial muscle mass you’ve worked so hard for.   The advantages of HGH go much further than muscle building and fat loss. It also works in the body to increase:

HGH secretions go way up during fasting. In fact, according to a 1988 study, a two-day fast can help you produce five times as much HGH! This is greatly beneficial for men and women because strong, lean, sturdy bodies are better for health than leaner, weaker muscles and skeletal frames.

And here’s the real key: to maximize the process of the brain being washed properly and HGH being produced excellently so you expand your creativity, productivity, vitality and longevity, you need five complete ninety-minute sleep cycles. That’s what the scientific studies are now confirming. That’s seven and a half hours of sleep each night. You also should know that research proves that it’s not only sleep-deprivation that kills. Over-sleep, nine or more hours, also has been shown to shorten life.

TO HEAL THE GUT, LIGAMENTS, TENDONS, AND SKIN: The peptide BPC-157 may promote speedier recovery from ligament tear reconstruction and rotator cuff tendon injuries. As we’ve already mentioned, this peptide has shown outstanding results in treating debilitating gut problems. I found that out firsthand after my bout with mercury poisoning, which does brutal things to the body. BPC-157 was one of the tools I used to help rebuild my gut, and it was extraordinarily effective. 5. TO INCREASE MUSCLE MASS, STRENGTHEN BONES, REVITALIZE SKIN, AND RESTORE YOUTHFUL METABOLISM: The two peptides sermorelin and tesamorelin mimic the action of growth hormone–releasing hormone (GHRH), a hotbed for new drug development. GHRHs stimulate the pituitary gland to secrete natural growth hormone. They’re a lot cheaper than synthetic human growth hormone (HGH)—and, unlike HGH, can be legally prescribed off-label. What’s the downside? If you take growth hormone or these peptides, you should be aware that growth hormone elevates levels of insulin-like growth factor-1, which has been shown in some studies to have “a modest association” with cancer risk.9 So it’s critical that you work closely with your physician to determine what options are best based on your symptoms, blood work, and careful monitoring.

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Other changes that are induced due to intermittent fasting are: Increased Human Growth Hormone(HGH): When you fast, the levels of different growth hormones in your body increase drastically. They have been observed to have increased up to 5 times. This in turn accelerates fat loss and muscle gain. Decreased Levels of Insulin: Through intermittent fasting, the levels of insulin in the body decreases by a lot. On the other hand, this also increases insulin sensitivity in the body. Insulin sensitive means how responsive to insulin your cells are. The decreased levels of insulin make stored body fat more accessible for different biological processes. Better Brain Health:  Another change that occurs when you take part in intermittent fasting is that the brain hormone BDNF increases in amount. It also helps in the growth of new nerve cells. Additionally, this type of fasting can help to protect against Alzheimer’s disease.

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They gave nine men a combination of human growth hormone (HGH) together with DHEA (another hormone) and metformin (the diabetes drug and potential anti-aging pill you might remember from the last chapter) to combat the diabetes risk associated with HGH. The results were positive, and quite wide-ranging: their thymuses look less fatty on an MRI scan and they have more T cells fresh from the thymus, as you’d hope—but they also saw improvements in kidney function and, most excitingly, a reduction in their epigenetic age, as measured by the morbidly accurate epigenetic clocks we met a couple of chapters ago. This suggests that rejuvenating the thymus can go on to rejuvenate the body more generally, not just the immune system—and, given the immune system’s wide remit for defense and maintenance around the body, perhaps this shouldn’t come as a surprise.

Moving the body regularly lifts your concentration, speeds up the processing potency of your brain as well as accelerating its learning capacity, raises your energy, elevates your optimism, helps you sleep better via the production of more melatonin and promotes longevity through the release of human growth hormone (HGH), along with the lengthening of your telomeres. Telomeres keep the ends of our chromosomes from fraying—they’re like plastic caps at the tips of shoelaces.

Through distillation, we learn that there is a water-soluble chemical component called boswellic acid that has been found to kill cancer as well as reverse arthritis. However, through further studies, we see that B. frereana contains little to no boswellic acid, while B. carteri and B. sacra contain 25 to 30 percent. Research shows that other family compounds like sesquiterpenes work directly on the anterior pituitary, stimulating human growth hormone (hGH) production, which slows the aging process and has been said by some scientists to reverse it. With this scientific research, it is evident that the healing properties of frankincense are determined by its chemical components.

強化適應的因素 首先是在預先疲勞狀態(pre-fatigued state)下進行訓練。如果我們在稍微耗盡的狀態，而非精神飽滿時進行所有高強度訓練，將能達到更深層的肝醣耗盡，並徵召很少使用的肌肉。因此，由於預先疲勞的關係，我們會得到不太一樣的訓練效果。我們可以讓運動員在完全恢復前就進行訓練，或安排一些訓練日是一天分別進行兩次高強度訓練，來控制訓練週期。 。如果我們想要增進自己的能力，用較少肝醣跑步，或更有效率的利用燃料，那麼我們可以透過營養來控制自己的燃料存量，以強化這樣的改變。最好的作法是空腹練跑或跑一段較長的時間但不補充燃料。跑步時如果燃料量低，身體就會知道自己必須更有效率的運作，才不會再次陷入燃料嚴重不足的境地。 我們一般都是靠長跑達到這樣的效果，但在空腹時跑步可更進一步推進此過程，因為我們基本上讓自己的燃料預先疲勞了;所以我們的身體被迫要找到方法來應付並適應這樣的狀況。同樣地，不要每次長跑都喝碳水化合物飲料或能量果凍，試試看跑步時只喝水會怎麼樣。這麼做的目的也一樣是要在長跑時儘量消耗肝醣，把肝醣濃度降得非常低，迫使身體適應。 最簡單的例子便是運動後的修復飲食。我們都被灌輸過訓練後補充碳水化合物或蛋白質的觀念，因此我在這裡不再詳談，但這麼做吋。確是有效的，蛋白質不只對肌肉修復很重要，對肌腱生長也不可或和修復。 更進一步利用蛋白質效果的方法是整天「補充」蛋白質，一天.中補充5份約20克的蛋白質，一整天都能提升蛋白質合成。此外，睡前補充大量蛋白質也能在睡眠中提升蛋白質合成，人體有大量恢復與修復的工作是在睡眠時進行。像這樣睡前補充蛋白質已獲證實是很好的方法。 。研究已證實睪固酮濃度在第一個REM循環時會上升，而人體生長激素(Human Growth Hormone,HGH)則會隨睡眠循環起伏。重點不是糾結於身體何時生成人體生長激素或睪固酮，而是知道如果太晚睡或睡眠循環受到干擾，將嚴重影響這兩個荷爾蒙，所以也會影響。身體的恢復與修復。 加拿大麥克馬斯特大學(Mcmaster Univenity)馬克。塔諾波斯基(Mark Tarnopolsky)最近進行的一項研究發現，按摩事實上會增加PGC-la的活性，同時減弱NF-kB,NF-kB是一種與肌肉發炎有關的蛋白質，而本書前半部很多篇幅都有提到PGC-la，它是一種前驅因子，可製造出更多粒線體。雖然這只是初步的研究，但仍顯示按摩可能是身體適應的一種增強因子(但也有可能是減弱因子)。 減弱適應的因素 一般都認為身體受到損傷是不好的，但事實上它是適應的信號兵，如果沒有造成任何傷害或打垮體內平衡，那麼身體無需適應和回應任何狀況。減弱適應的因素大部分是會影響所產生之傷害的事物。我們可以從發炎反應開始談起;當我們造成肌肉輕微撕裂傷時，身體會經歷一個發炎循環，以啟動修復程序並強化肌肉。這是自然而然發生的，是件好事，但我們往往想用人為的方式加快這段過程，像是服用抗發炎藥物或跳入冰水中。 i藥物或物質會清除部分的發炎生物標記物，而這些生物標記物會觸發訊息傳遞;因此如果清除了這些標記物，將減弱訊息傳遞路徑的活化，最後轉換成功能性適應的物質就變少了。較簡單的說法就是，如果身體察覺到大量發炎，它會使用重型修復設備，強化防禦力使其更穩固。但若突然之間出現第三方處理了部分傷害，那麼身體會直接認為「喔，問題並沒有我們所想得那麼嚴重，所以不需要如預期的投入這麼多力氣修補。」 除了抗發炎藥物以外，抗氧化劑也具有相同的效果。跑步時身體會發生氧化作用，且能觸發粒線體數量增多，便能應付這些前誘導氧化物。但如果突然之間我們服用了人造抗氧化劑，就會再次有第三方化身清潔隊，關閉身體主要需適應的訊號。有趣地是，根據研究，似乎只有人造抗氧化維生素會產生如此強烈的效果，水果中含有的天然抗氧化劑並不具此效果。