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But my favourite cautionary tale is of Australian junior doctor Barry Marshall and his pathologist colleague Robin Warren. In the early 1980s they disagreed with the general medical consensus that most stomach ulcers were caused by stress, bad diet, alcohol, smoking and genetic factors. Instead Marshall and Warren were convinced that a particular bacterium, Helicobacter pylori, was the cause. And if they were right, the solution to many patients’ ulcers could be a simple course of antibiotics, not the risky stomach surgery that was often on the cards. Barry must have picked the short straw, because instead of setting up a test on random members of the public – and having to convince those well-known fun-skewerers of human trials: ethics committees – he just went ahead and swallowed a bunch of the little bugs. Imagine the joy, as his hypothesis was proved right! Imagine the horror, as his stomach became infected, which led to gastritis, the first stage of the stomach ulcers! Imagine his poor wife and family, as the vomiting and halitosis became too much to bear! Dr Marshall lasted 14 days before taking antibiotics to kill the H. pylori, but it was another 20 years before he and Warren were awarded the 2005 Nobel Prize for Physiology or Medicine. So, hang on, is self-experimenting really that bad if it wins you a Nobel Prize? I guess you can only have a go and find out…but please don’t go as far as US army surgeon Jesse Lazear: in trying to prove that yellow fever was contagious, and that infected blood could be transferred via mosquito bites, he was bitten by one and died. The mosquito that caused his death might not even have been part of his experiment. It’s thought that it could just have been a local specimen. But one that enjoyed both biting humans and dramatic irony. Gastrointestinal elements
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