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7 Severe hemophagocytic syndrome with failure of one or more organs. The choice of cytoreductive regimen depends on the type of malignancy, which is not always precisely known on arrival of the patient in the ICU. For acute leukemias, efforts should be made to characterize the lineage (ALL or AML) before treatment is initiated, but if lineage cannot be determined, a non–lineage-specific
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Jean-Louis Vincent (Textbook of Critical Care E-Book: Expert Consult Premium Edition – Enhanced Online Features and Print)