“
First she would try to kill him, but failing this give him food and her body, breast-feed him back to a state of childishness and even, perhaps, feel affection for him. Then, the moment he was asleep, cut his throat. The synopsis of the ideal marriage.
”
”
J.G. Ballard (High-Rise)
“
When the hour comes it is to remind him of a story. Synopsis: A French girl says to her suitor: “Did you ask my father for my hand at nine o’clock this morning, as you said you would?” “I did not,” he. replies. “At nine o’clock I was fighting a duel with swords in the Bois de Boulogne.” “Coward!” she hisses.
”
”
O. Henry (Delphi Complete Works of O. Henry (Illustrated))
“
This just gets worse and worse," Rob Pierre sighed as he skimmed Leonard Boardman's synopsis of his latest gleanings from the Solarian League reporters covering the PRH. "How can one person—one person, Oscar!—do this much damage? She's like some damned elemental force of nature!"
"Harrington?" Oscar Saint-Just quirked an eyebrow and snorted harshly at Pierre's nodded confirmation.
"She's just happened to be in the right places—or the wrong ones, I suppose, from our perspective—for the last, oh, ten years or so. That's the official consensus from my analysts, at least. The other theory, which seems to have been gaining a broader following of late, is that she's in league with the Devil.
”
”
David Weber (Ashes of Victory (Honor Harrington, #9))
“
Someone told me once, ‘It’s time to get you a pair of overalls, boy.’ But I don’t believe in summing up nothin’ – I let my experiences speak for themselves – and even if I did, a synopsis should be singular. That’s why every time I go out to work in the fields, I work naked. It lets my neighbors speak of my experiences for me.
”
”
M.C. Humphreys
“
As the chips dissolved on my tong, the embedded video links travelled to my brain. Tapping into my synopsis and taking hold of my senses. They transported me to another time and place. I was no longer in Mackiel's office. I was in the palace. And I was covered in blood.
”
”
Astrid Scholte (Four Dead Queens)
“
Your identity does not have to be cohesive. Your story doesn’t have to flow. You don’t have to be neatly packaged in a way that other people understand. You have to stop living for your synopsis, the summary we try to piece together in our minds when we imagine people explaining us or evaluating who we are. It doesn’t have to make sense. You’re allowed to be great at a lot of things that don’t necessarily relate to one another. You’re not limited to just one purpose, one talent, one love. You can have a variety of jobs, each of them meaningful at the time you have them. You can be good at a lot of things without lacking in others. You do not have to be a novel; you can be a book of stories.
”
”
Brianna Wiest (101 Essays That Will Change The Way You Think)
“
Lengo la jina la kitabu ni kuishawishi hadhira kusoma dibaji, na lengo la dibaji ni kuishawishi hadhira kusoma salio la kitabu kizima.
”
”
Enock Maregesi
“
According to the biographical notes, Monsieur Julian Carax was twenty-seven, born with the century in Barcelona, and currently living in Paris; he wrote in French and worked at night as a professional pianist in a hostess bar. The blurb, written in the pompous, moldy style of the age, proclaimed that this was a first work of dazzling courage, the mark of a protean and trailblazing talent, and a sign of hope for the future of all of European letters. In spite of such solemn claims, the synopsis that followed suggested that the story contained some vaguely sinister elements slowly marinated in saucy melodrama, which, to the eyes of Monsieur Roquefort, was always a plus: after the classics what he most enjoyed were tales of crime, boudoir intrigue, and questionable conduct.
One of the pitfalls of childhood is that one doesn't have to understand something to feel it. By the time the mind is able to comprehend what has happened, the wounds of the heart are already too deep.
She laughed nervously. She had around her a burning aura of loneliness. "You remind me a bit of Julian," she said suddenly. "The way you look and your gestures. He used to do what you are doing now. He would stare at you without saying a word, and you wouldn't know what he was thinking, and so, like an idiot, you'd tell him things it would have been better to keep to yourself."
"Someone once said that the moment you stop to think about whether you love someone, you've already stopped loving that person forever."
I gulped down the last of my coffee and looked at her for a few moments without saying anything. I thought about how much I wanted to lose myself in those evasive eyes. I thought about the loneliness that would take hold of me that night when I said good-bye to her, once I had run out of tricks or stories to make her stay with me any longer. I thought about how little I had to offer her and how much I wanted from her.
"You women listen more to your heart and less to all the nonsense," the hatter concluded sadly. "That's why you live longer."
But the years went by in peace. Time goes faster the more hollow it is. Lives with no meaning go straight past you, like trains that don't stop at your station.
”
”
Carlos Ruiz Zafón (The Shadow of the Wind (The Cemetery of Forgotten Books, #1))
“
The synopsis looked good,
the cover looked nice,
you opened the book
and began a new life.
You found a new home,
you met some new friends,
you kept on reading,
hoping it ould never end.
You danced through the pages,
you sang out the words
you felt all their joy,
and all their pain and hurt.
The pages cut your fingers,
and the words cut your heart,
like the author had a knife,
and was tearing your soul apart.
You laughed with the characters,
and with them, you cried,
you fell in love with them, too
but with them, you died,
and when the book reached its end,
and your broken heart couldn't heal,
you suddenly realized that
its
not
real.
”
”
Anonymous
“
Good cover design is not only about beauty... it’s a visual sales pitch. It’s your first contact with a potential reader. Your cover only has around 3 seconds to catch a browsing reader’s attention. You want to stand out and make them pause and consider, and read the synopsis.
”
”
Eeva Lancaster (Being Indie: A No Holds Barred, Self Publishing Guide for Indie Authors)
“
Sometimes when things seem like they are falling apart, they are actually falling into place.
”
”
Zaid Ismail (The Egosystem: A synopsis of the human condition)
“
The interaction of the two systems is a recurrent theme of the book, and a brief synopsis of the plot is in order.
”
”
Daniel Kahneman
“
Tormented' in a synopsis is a new red flag for bad smut.
”
”
Chamonix
“
memory does not store a feature-length film of our experience but instead stores an idiosyncratic synopsis,
”
”
Daniel Todd Gilbert (Stumbling on Happiness: An insightful neuroscience self-help psychology book on cognitive enhancement and human behavior)
“
Did you read one of his follow-up books?”
“No, I read the title, and a synopsis.”
“A synopsis.”
Martin shrugged. “Part of the synopsis.”
“Ah, yes,” Phillip said. “You’re an American.
”
”
Scott Meyer
“
He imagines the synopsis on the back of the Jenny story: when plucky Jenny from Fairfield, Connecticut, took a job as a social worker in the big city, she had no idea what she was getting into.
”
”
Gabrielle Zevin (The Storied Life of A.J. Fikry)
“
You only have one chance to make a great first impression. You make that first impression with a great cover, an intriguing synopsis, and professional editing. Let my inner editor polish your manuscript the 'write' way.
”
”
Rogena Mitchell-Jones
“
What we find in philosophy is trivial; it does not teach us new facts, only science does that. But the proper synopsis of these trivialities is enormously difficult, and has immense importance. Philosophy is in fact the synopsis of trivialities.
”
”
Ludwig Wittgenstein
“
From tender infancy Smith has been an early riser. He sleeps so little that Morpheus barely knows him by sight. When he dreams he only has time for a synopsis. He was the first man to discover that you can cut a sleeping pill in half and enjoy a nap.
”
”
H. Allen Smith (Low Man on a Totem Pole)
“
Synopsis: A French girl says to her suitor: “Did you ask my father for my hand at nine o’clock this morning, as you said you would?” “I did not,” he replies. “At nine o’clock I was fighting a duel with swords in the Bois de Boulogne.” “Coward!” she hisses.
”
”
O. Henry (O. Henry: Complete Stories: Cabbages and Kings, Heart of the West, The Voice of the City, Rolling Stones... (Bauer Classics) (All Time Best Writers Book 16))
“
Today the formation of God’s people into an army is a matter of coordination, which is based on three matters: life, maturity, and confirmation. These three matters must be fulfilled in order for God’s people to be properly formed, which is to be properly coordinated. (CWWL, 1960, vol. 1, “Synopsis of Numbers,” p. 71)
”
”
Witness Lee (The Holy Word for Morning Revival - Crystallization-study of Numbers, Volume 3)
“
Majina ya vitabu yanapaswa kuchaguliwa kwa mantiki na kwa makini ya hali ya juu mno, kwa sababu ni miongoni mwa vitu vya kwanza watu wanavyoviona na kuvisoma. Watu wakivutiwa na jina la kitabu, au mwandishi; kitu cha pili watakachovutiwa kuangalia ni dibaji, kusudi wasome muhtasari wa kitabu kizima. Kwa hiyo dibaji inapaswa iandikwe kwa mantiki na kwa makini ileile iliyotumika katika kuchagua jina la kitabu. Lengo la jina la kitabu na dibaji ni kuishawishi hadhira kusoma kitabu na kukifurahia.
”
”
Enock Maregesi
“
I feel sick when I look at the parody synopsis, at the letters from the film company... The novel is 'about' a colour problem. I said nothing in it that wasn't true. But the emotion it came out of was something frightening, the unhealthy, feverish illicit excitement of wartime, a lying nostalgia, a longing for licence, for freedom, for the jungle, for formlessness. It is so clear to me that I can't read that novel now without feeling ashamed, as if I were in a street naked. Yet no one else seems to see it. Not one of the reviewers saw it. Not one of my cultivated and literary friends saw it. It is an immoral novel because that terrible lying nostalgia lights every sentence.
”
”
Doris Lessing (The Golden Notebook)
“
Survivors don't enjoy the sweetness of life. They simply enjoy the deferral of death.
”
”
Zaid Ismail (The Egosystem: A synopsis of the human condition)
“
Here's an assignment for you: Write it down. Write down under what circumstances you're willing to quit. And when. And then stick to it.
”
”
Seth Godin (The Dip: A Little Book That Teaches You When to Quit (and When to Stick) - Seth Godin (Summary by ReadSmartly) Synopsis & Abstract)
“
Psychotropic drugs have also been organized according to structure (e.g., tricyclic), mechanism (e.g., monoamine, oxidase inhibitor [MAOI]), history (first generation, traditional), uniqueness (e.g., atypical), or indication (e.g., antidepressant). A further problem is that many drugs used to treat medical and neurological conditions are routinely used to treat psychiatric disorders.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
My journaling method ranges from being a very specific, structured process—listing what I’m grateful for, acknowledging my accomplishments, clarifying what areas I want to improve on, and planning which specific actions I’m committed to taking to improve—to being pretty traditional, just a dated entry with a synopsis of my day. I find both to be very valuable, and it’s nice to mix it up.
”
”
Hal Elrod (The Miracle Morning: The Not-So-Obvious Secret Guaranteed to Transform Your Life: Before 8AM)
“
You really are one heck of a pretty woman,’ [he] says.
…’Pretty is not a good reason to court someone, you know…’
‘This from the woman who doesn’t read the books with the ugly covers.’
‘Well, I’m just warning you. I could be a bad book with a good jacket.’
…’Nah, I’ve seen you on the shelf for years. I’ve read the synopsis and the quotes on the back. … it’s enough to make me want to read on….
”
”
Gabrielle Zevin (The Storied Life of A.J. Fikry)
“
But trivial as are the topics they are not utterly without a connecting thread of motive. As the reader's eye strays, with hearty relief, from these pages, it probably alights on something, a bed-post or a lamp-post, a window blind or a wall. It is a thousand to one that the reader is looking at something that he has never seen: that is, never realised. He could not write an essay on such a post or wall: he does not know what the post or wall mean. He could not even write the synopsis of an essay; as "The Bed-Post; Its Significance—Security Essential to Idea of Sleep—Night Felt as Infinite—Need of Monumental Architecture," and so on. He could not sketch in outline his theoretic attitude towards window-blinds, even in the form of a summary. "The Window-Blind—Its Analogy to the Curtain and Veil—Is Modesty Natural?—Worship of and Avoidance of the Sun, etc., etc." None of us think enough of these things on which the eye rests. But don't let us let the eye rest. Why should the eye be so lazy? Let us exercise the eye until it learns to see startling facts that run across the landscape as plain as a painted fence. Let us be ocular athletes. Let us learn to write essays on a stray cat or a coloured cloud. I have attempted some such thing in what follows; but anyone else may do it better, if anyone else will only try.
”
”
G.K. Chesterton (Tremendous Trifles)
“
The lore which he was believed to pass his days brooding upon so that it had rapt him from the companionship of youth was only a garner of slender sentences from Aristotle's poetics and psychology and a Synopsis Philosophiæ Scholasticæ ad mentum divi Thomæ. His thinking was a dusk of doubt and self-mistrust, lit up at moments by the lightnings of intuition, but lightnings of so clear a splendour that in those moments the world perished about his feet as if it had been fire consumed: and thereafter his tongue grew heavy and he met the eyes of others with unanswering eyes, for he felt that the spirit of beauty had folded him round like a mantle and that in reverie at least he had been acquainted with nobility. But when this brief pride of silence upheld him no longer he was glad to find himself still in the midst of common lives, passing on his way amid the squalor and noise and sloth of the city fearlessly and with a light heart.
”
”
James Joyce (A Portrait of the Artist as a Young Man)
“
Over a quarter of the scenario writers were women and many of them were already friends, including June Mathis, Agnes Christine Johnston, Dorothy Farnum, Gladys Unger, and Winifred Eaton Reeve. Most had entered the business at a time when a one-page synopsis of action could be turned into a two-reeler, but they had grown with the industry and were now well paid and highly valued for their abilities. The women were as likely to write jungle films or swashbucklers as tales of female angst and Thalberg maintained that his preference for women writers was a commercial one.
”
”
Cari Beauchamp (Without Lying Down: Frances Marion and the Powerful Women of Early Hollywood)
“
selective serotonin reuptake inhibitor (SSRI) and serotonin–norepinephrine reuptake inhibitors (SNRIs) are now used as primary treatments, with benzodiazepines used as adjuncts. Benzodiazepine abuse is rare, usually found in patients who abuse multiple prescription and recreational drugs.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
Your book sells itself—OR doesn’t sell itself—in ten specific ways. We’re going to spend some time talking about each one of them in depth, asking you specific questions to see if you are using each of these aspects of your book to their fullest potential, but let’s start by taking a look at all ten of them together:
1) The Genre
2) The Cover
3) The Title
4) The Back Blurb / Synopsis
5) The Tagline / Extra Promotional Lines
6) Interior Formatting
7) Editing
8) Keywords
9) Categories
10) And YOU as the author (your marketing mindset)
Each of these things can make or break book sales.
”
”
Bethany Atazadeh (How Your Book Sells Itself (Marketing for Authors, #1))
“
Barbara took her accustomed place by the door but as the singing began Margerit beckoned her over to her side. "I haven't been following much except that it's all ancient Greeks and battles and such. What's happening now?"
Barbara knelt beside her and leaned close to whisper so as not to disturb the rest of the party. A brief synopsis of what had gone before took up the time while the chorus escorted the principles to the centre of the stage. "I haven't seen this performance before," Barbara added, "but I imagine this will be the grand love duet." As the soprano began, she concentrated on the stage to follow the opening phrases. The chorus had abandoned the field to the principles who faced each other against a backdrop of fluted columns.
"O! What strange fate is mine!" Barbara paused as the signature line was repeated several times. "I loved you in the guise of Mars, but now I am betrayed by Venus. The iron in your glance turns soft beneath my touch. I am undone. O Venus, you are cruel to mock me so." It continued on in the same vein until it was the mezzo's turn. Her lyrics ran much parallel with the soprano's. With less concentration required, Barbara ventured a glance to see Margerit's reaction. Margerit turned at the same moment and their eyes met as Barbara whispered Ifis's lines.
"O! What a strange fate is mine! In the guise of Mars I love you but now as Venus I'm betrayed. The Iron in my soul turns soft beneath your touch." Unconsciously, Margerit placed a hand on hers where it lay on the arm of her chair. "Fire runs through my veins - I am undone." Fire indeed ran through her veins. Her hand burned sweetly where Margerit touched it and she dared now take it back. Her voice grew husky. "Why do the gods mock me with desire I cannot sate?" Their eyes were still locked and Margerit's lips had parted in a little "o" of wonder. "O Venus, have mercy on one new come to your shrine."
When the soprano joined again for the duet, Margerit breathed along with her, "O! What strange fate is mine!"
With effort, Barbara wrenched her gaze away.
”
”
Heather Rose Jones (Daughter of Mystery (Alpennia, #1))
“
The complex interplay of the emotions, however, is far beyond the understanding of functional neuroanatomists. Where, for example, are the representations of the id, ego, and and the superego? Through what pathway are ethical and moral judgments shepherded? What processes allow beauty to be in the eye of the beholder? These philosophical questions represent a true frontier of human discovery.
”
”
Benjamin James Sadock (Kaplan And Sadocks Synopsis Of Psychiatry 11Ed (Pb 2015))
“
UKIP SHIPPING FORECAST by Nicholas Pegg After a UKIP councillor claimed widespread flooding in the UK was God’s punishment for allowing same-sex marriage, author/performer Nicholas Pegg wrote his own version of the Shipping Forecast. His recording went viral, receiving 250,000 hits in four days. ‘And now the shipping forecast issued by UKIP on Sunday the 19 January 2014 at 1200 UTC. There are warnings of gays in Viking, Forties, Cromarty, Southeast Iceland and Bongo Bongo land. The general synopsis at midday: Low intelligence expected, becoming Little England by midnight tonight. And now the area forecasts for the next 24 hours. Viking, North Utsire, South Utsire: south easterly gay seven to severe gay nine, occasionally bisexual. Showers – gay. Forties, Cromarty, Forth, Tyne, Dogger, Fisher: women veering southerly 4 or 5, losing their identity and becoming sluts. Rain – moderate or gay. German blight, immigration veering north – figures variable, becoming psychotic. Showers – gay. Humber, Thames, Dover, Wight, Portland, Plymouth: benefit tourism 98%, becoming variable – later slight, or imaginary. Showers – gay. Biscay, Trafalgar: warm, lingering nationalism. Kiss me Hardy, later becoming heterosexual – good. FitzRoy, Sole, Lundy, Fastnet, Irish Sea, Shannon, Rockall, Malin, Hebrides, Bailey: right or extreme right, veering racist 4 or 5, increasing to 5 to 7. Homophobic outburst – back-peddling westerly and becoming untenable. Showers – gay. Fair Isle, Faeroes, South East Iceland: powerbase decreasing, variable – becoming unelectable. Good. And that concludes the forecast.
”
”
Nic Compton (The Shipping Forecast: A Miscellany)
“
Could it be that the man over there, gesticulating with a cocktail stick, is screaming on the inside, ‘Why did I start this story? There’s no punchline. How can I bail out? These people must hate me. Make your excuses and leave NOW!’ See that woman over there, passionately describing why she loved the latest Star Wars film? Is she really paddling wildly and thinking, ‘They know I haven’t seen it, I’ve only read the synopsis, but I thought it would help me fit in. I am not even sure Chewbacca is in it.’ See that guy over there, throwing his head back in laughter as he eats a devilled egg? He doesn’t know what he’s laughing about, and he just imagined throwing himself out of that open window. I wonder if the secret of the social human is to tactfully conceal the fact that you’re screaming on the inside. Or am I just projecting my scream onto others?
”
”
Robin Ince (I'm a Joke and So Are You: Reflections on Humour and Humanity)
“
If I walk along a shore towards a ship which has run aground, and the funnel or masts merge into the forest bordering on the sand dune, there will be a moment when these details suddenly become part of the ship, and indissolubly fused with it. As I approached, I did not perceive resemblances or proximities which finally came together to form a continuous picture of the upper part of the ship. I merely felt that the look of the object was on the point of altering, that something was imminent in this tension, as a storm is imminent in storm clouds.
Suddenly the sight before me was recast in a manner satisfying to my vague expectation. Only afterwards did I recognize, as justifications for the change, the resemblance and contiguity of what I call ‘stimuli’— namely the most determinate phenomena, seen at close quarters and with which I compose the ‘true’ world. ‘How could I have failed to see that these pieces of wood were an integral part of the ship? For they were of the same colour as the ship, and fitted well enough into its superstructure.’ But these reasons for correct perception were not given as reasons beforehand. The unity of the object is based on the foreshadowing of an imminent order which is about to spring upon us a reply to questions merely latent in the landscape. It solves a problem set only in the form of a vague feeling of uneasiness, it organizes elements which up to that moment did not belong to the same universe and which, for that reason, as Kant said with profound insight, could not be associated. By placing them on the same footing, that of the unique object, synopsis makes continuity and resemblance between them possible. An impression can never by itself be associated with another impression.
”
”
Maurice Merleau-Ponty (Phenomenology of Perception)
“
We saw in the discussion of the law of small numbers that a message, unless it is immediately rejected as a lie, will have the same effect on the associative system regardless of its reliability. The gist of the message is the story, which is based on whatever information is available, even if the quantity of the information is slight and its quality is poor: WYSIATI. When you read a story about the heroic rescue of a wounded mountain climber, its effect on your associative memory is much the same if it is a news report or the synopsis of a film. Anchoring results from this associative activation. Whether the story is true, or believable, matters little, if at all. The powerful effect of random anchors is an extreme case of this phenomenon, because a random anchor obviously provides no information at all. Earlier I discussed the bewildering variety of priming effects, in which your thoughts and behavior may be influenced by stimuli to which you pay no attention at all, and even by stimuli of which you are completely unaware. The main moral of priming research is that our thoughts and our behavior are influenced, much more than we know or want, by the environment of the moment. Many people find the priming results unbelievable, because they do not correspond to subjective experience. Many others find the results upsetting, because they threaten the subjective sense of agency and autonomy. If the content of a screen saver on an irrelevant computer can affect your willingness to help strangers without your being aware of it, how free are you? Anchoring effects are threatening in a similar way. You are always aware of the anchor and even pay attention to it, but you do not know how it guides and constrains your thinking, because you cannot imagine how you would have thought if the anchor had been different (or absent). However, you should assume that any number that is on the table has had an anchoring effect on you, and if the stakes are high you should mobilize yourself (your System 2) to combat the effect.
”
”
Daniel Kahneman (Thinking, Fast and Slow)
“
Medications used to treat psychiatric disorders are commonly referred to as psychotropic drugs. These drugs are commonly described by their major clinical application, for example, antidepressants, antipsychotics, mood stabilizers, anxiolytics, hypnotics, cognitive enhancers, and stimulants. A problem with this approach is that these drugs have multiple indicators. For example, selective serotonin reuptake inhibitors (SSRls) are both antidepressants and anxiolytics, and the serotonin-dopamine antagonists (SDAs) are both anxiolytics and mood stabilizers.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
Infinite Jest (V?). Year of the Trial-Size Dove Bar. Poor Yorick Entertainment Unlimited. 'Madame Psychosis' ; no other definitive data. Thorny problem for archivists. Incandenza's last film, Incandenza's death occurring during its post-production. Most archival authorities list as unfinished, unseen. Some list as completion of Infinite Jest (IV), for which Incandenza also used 'Psychosis,' thus list the film under Incandenza's output for Y.T.M.P. Though no scholarly synopsis or report of viewing exists, two short essays in different issues of Cartridge Quarterly East refer to to film as 'extraordinary' and 'far away [James O. Incandenza's] most entertaining and compelling work.' West Coast archivists list the film's gauge as '16...78... n mm.,' basing the gauge on critical allusions to 'radical experiments in viewers' optical perspective and context' as IJ (V?)'s distinctive feature. Though Canadian archivist Tete-Beche lists the film as completed and privately distributed by P.Y.E.U. through posthumous provisions in the filmmaker's will, all other comprehensive filmographies have the film either unfinished or UNRELEASED, its Master cartridge either destroyed or vaulted sui testator.
”
”
David Foster Wallace (Infinite Jest)
“
The issues of antidepressant-associated suicide has become front-page news, the result of an analysis suggesting a link between medication use and suicidal ideation among children, adolescents, a link between medication use and suicidal ideation among children, adolescents, and adults up to age 24 in short term (4 to 16 weeks), placebo-controlled trials of nine newer antidepressant drugs. The data from trials involving more than 4.4(K) patients suggested that the average risk of suicidal thinking or behavior (suicidality) during the first few months of treatment in those receiving antidepressants was 4 percent, twice the placebo risk of 2 percent. No suicides occured in these trials. The analysis also showed no increase in suicide risk among the 25 to 65 age group. Antidepressants reduced suicidality among those over age 65. Following public hearings on the subject, in October 2004, the FDA requested the addition of “black box” warnings—the most serious warning placed on the labeling of a prescription medication—to all antidepressant drugs, old and new.
”
”
Benjamin James Sadock (Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
it is often best if benzodiazepine agents are used in conjunction with psychotherapy and when alternative agents have been tried and proven ineffective or poorly tolerated.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
The fact that all benzodiazepines are lipid soluble to varying degrees means that benzodiazepines and their active metabolites bind to plasma proteins. The extent of this binding is proportional to their lipid solubility. The amount of protein binding varies from 70 to 99 percent. Distribution, onset, and termination of action after a single dose are thus largely determined by benzodiazepine lipid solubility, not elimination
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
half-life. Preparations with high lipid solubility, such as diazepam and alprazolam, are absorbed rapidly from the GI tract and distribute rapidly to the brain by passive diffusion along a concentration gradient, resulting in a rapid onset of action. However, as the concentration of the medication increases in the brain and decreases in the bloodstream, the concentration gradient reverses itself, and these medications leave the brain rapidly, resulting in fast cessation of drug effect.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
administration of medications more frequently than the elimination half-life leads to drug accumulation, medications such as diazepam and flurazepam accumulate with daily dosing, eventually resulting in increased daytime sedation.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
administration of medications more frequently than the elimination half-life leads to drug accumulation, medications such as diazepam and flurazepam accumulate with daily dosing, eventually resulting in increased daytime sedation. Some benzodiazepines (e.g., oxazepam) are conjugated directly by glucuronidation and are excreted.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
more than 120 hours.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
Zolpidem, zaleplon, and eszopiclone are rapidly and well absorbed after oral administration, although absorption can be delayed by as long as 1 hour if they are taken with food.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
Because insomnia may be a symptom of a physical or psychiatric disorder, hypnotics should not be used for more than 7 to 10 consecutive days without a thorough investigation of the cause of the insomnia.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
The rapid metabolism and lack of active metabolites of zolpidem, zaleplon, and eszopiclone avoid the accumulation of plasma concentrations compared with the long-term use of benzodiazepines.
”
”
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
“
The benzodiazepine hypnotics differ principally in their half-lives; flurazepam has the longest half-life, and triazolam has the shortest. Flurazepam may be associated with minor cognitive impairment on the day after its administration, and triazolam may be associated with mild rebound anxiety and anterograde
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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dysfunction and weight gain. However, the SSRIs are still often preferred because they target common comorbid conditions, such as depression or obsessive-compulsive disorder (OCD). Benzodiazepines and SSRIs can be initiated together to treat acute panic symptoms; use of the benzodiazepine can be tapered after 3 to 4 weeks after the therapeutic benefits of the SSRI have emerged.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Clonazepam has been shown to be an effective treatment for social phobia. In addition, several other benzodiazepines (e.g., diazepam) have been used as adjunctive medications for treatment of social phobia.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Chronic catatonia does not respond as well to benzodiazepines. The definitive treatment for catatonia is electroconvulsive therapy.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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frequently associated with bipolar disorder than with schizophrenia
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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A small number of persons with idiopathic Parkinson’s disease respond to long-term use of zolpidem with reduced bradykinesia and rigidity. Zolpidem dosages of 10 mg four times daily may be tolerated without sedation for several years.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The benzodiazepines (especially IM lorazepam) are used to manage substance induced and psychotic agitation in the emergency department. Benzodiazepines have been used instead of amobarbital (Amytal) for drug-assisted interviewing.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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associated with the use of flumazenil is the precipitation of seizures, which is especially likely to occur in persons with seizure disorders, those who are physically dependent on benzodiazepines, and those who have ingested large quantities of benzodiazepines. Flumazenil
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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With flumazenil treatment, the tricyclic-induced seizures or cardiac arrhythmias may appear and result in a fatal outcome. Flumazenil does not reverse the effects of ethanol, barbiturates, or opioids.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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additional flumazenil is unlikely to have an effect. Sedation can return in 1 to 3 percent of persons treated with flumazenil. It can be prevented or treated by giving repeated dosages of flumazenil at 20-minute intervals. For repeat treatment, no more than 1 mg (given as 0.5 mg a minute) should be given at any one time, and no more than 3 mg should be given in any 1 hour.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The most serious adverse effects of the benzodiazepines occur when other sedative substances, such as alcohol, are taken concurrently. These combinations can result in marked drowsiness, disinhibition, or even respiratory depression. Infrequently, benzodiazepine receptor agonists cause mild cognitive deficits that may impair job performance. Persons taking benzodiazepine receptor agonists should be advised to exercise additional caution when driving or operating dangerous machinery.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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High-potency benzodiazepines, especially triazolam, can cause anterograde amnesia. A paradoxical increase in aggression has been reported in persons with preexisting brain damage.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Triazolam has received significant attention in the media because of an alleged association with serious aggressive behavioral manifestations. Therefore, the manufacturer recommends that the drug be used for no more than 10 days for treatment of insomnia and that physicians carefully evaluate the emergence of any abnormal thinking or behavioral changes in persons treated with triazolam, giving appropriate consideration to all potential causes. Triazolam was banned in Great Britain in 1991.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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persons with a history of substance abuse, cognitive disorders, renal disease, hepatic disease, porphyria, central nervous system (CNS) depression, or myasthenia gravis.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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the use of benzodiazepines in the third trimester can precipitate a withdrawal syndrome in newborns. The drugs are secreted in the breast milk in sufficient concentrations to affect newborns. Benzodiazepines may cause dyspnea, bradycardia, and drowsiness in nursing babies.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Zolpidem and zaleplon are secreted in breast milk and are therefore contraindicated for use by nursing mothers. The dosage of zolpidem and zaleplon should be reduced in elderly persons and persons with hepatic impairment.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Benzodiazepine withdrawal syndrome consists of anxiety, nervousness, diaphoresis, restlessness, irritability, fatigue, lightheadedness, tremor, insomnia, and weakness (Table 29.9-2). Abrupt discontinuation of benzodiazepines, particularly those with short half-lives, is associated with severe withdrawal symptoms,
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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which may include depression, paranoia, delirium, and seizures.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Alprazolam seems to be particularly associated with an immediate and severe withdrawal syndrome and should be tapered gradually.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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be tapered slowly (25 percent a week); otherwise, recurrence or rebound of symptoms is likely.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The dosage range of carbamazepine used to facilitate withdrawal is 400 to 500 mg a day. Some clinicians report particular difficulty in tapering and discontinuing alprazolam, especially in persons who have been receiving high dosages for long periods. There have been reports of successful discontinuation of alprazolam by switching to clonazepam, which is then gradually withdrawn.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The combination of benzodiazepines and clozapine (Clozaril) has been reported to cause delirium
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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and should be avoided.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The manufacturer of nefazodone recommends that the dosage of triazolam be lowered by 75 percent and the dosage of alprazolam be lowered by 50 percent when given concomitantly with nefazodone.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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may decrease the plasma concentrations of benzodiazepines, and smoking may increase the metabolism of benzodiazepines.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The SSRIs may prolong and exacerbate the severity of zolpidem-induced hallucinations. Deaths have been reported when parental lorazepam is given with parental olanzapine.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The plasma concentrations of triazolam and alprazolam are increased to potentially toxic concentrations by nefazodone (Serzone) and fluvoxamine (Luvox).
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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antacids may reduce the GI absorption of benzodiazepines.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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An estimated length of therapy should be decided at the beginning of therapy, and the need for continued therapy should be reevaluated at least monthly because of the problems associated with long-term use.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Alprazolam is available in an extended-release form, which reduces the frequency of dosing.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Fibber is probably the only adult in Wistful Vista who prefers a synopsis of a cartoon to that of a feature film.
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Clair Schulz (FIBBER McGEE & MOLLY ON THE AIR, 1935-1959 (REVISED AND ENLARGED EDITION))
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Why (in the US) did the term stay the same, and the meaning change? Because, in fact, the real meaning has not changed. In 1858 as in 2008, a “liberal” is a supporter of the Cathedral: i.e., a Whig, a progressive, a Radical, etc. It is the Synopsis that shifted, and it is today’s libertarians who are not with the program.
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Mencius Moldbug (An Open Letter to Open-Minded Progressives)
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I shrug, wincing. "I hated him until I didn't?"
"That's actually a very accurate synopsis." Ethan slides an arm around my shoulders again.
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Christina Lauren (The Unhoneymooners (Unhoneymooners, #1))
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Though Arjuna deplores this state of inertia and self-pity, he is unable to shake it off. This is often our problem too; we can diagnose our shortcomings and even give a brilliant synopsis of the world’s woes, but as long as our knowledge is limited to intellectual analysis, we will not have the capacity to make the world more peaceful; we will not be able to prevent pollution or even bring together estranged families and friends. It is the deeper will and wisdom which come through meditation that enable us to tap the creative resources and untiring energy lying latent in our consciousness.
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Eknath Easwaran (The Bhagavad Gita for Daily Living: A Verse-by-Verse Commentary: Vols 1–3 (The End of Sorrow, Like a Thousand Suns, To Love Is to Know Me) (The Bhagavad Gita for Daily Living, 1))
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Shrinks are here to edit your emotions with adjectives in order to create a TV Guide synopsis of your issues. Today on an episode of Iris in Therapy, we discover she has never felt heard!
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Tarryn Fisher (Good Half Gone)
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Creating Space Tourism Desire
by JOHN LOK
Synopsis
How can we persuade the rich people like to catch rockets to fly to space to travel ? What factors may influence rich passengers feel fear to catch rockets to travel space? In my this book, I shall attempt to explain what factors may influence future space tourism market development as well as how to raise rich people entertainment need for space tourism.
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John Lok
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I have recommended Kevin Kelly’s “1,000 True Fans” to literally millions of people. Many guests in this book have done the same. “If you only read one article on marketing, make it this one” is my common wording. Here’s a highly simplified synopsis: “Success” need not be complicated. Just start with making 1,000 people extremely, extremely happy.
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Timothy Ferriss (Tools of Titans: The Tactics, Routines, and Habits of Billionaires, Icons, and World-Class Performers)
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As times got worse in 1929, these groups and the German public at large kept beating the same drum. “See what the November criminals, the Versailles Treaty, the Allies, the communists, and the Jews have done to Germany?” “Germans have lost everything.” “The people are begging in the streets. The people have no dignity. No honor.” “Hitler will restore Germany’s strength, honor, and dignity!” Just right there, you essentially have a synopsis of every speech made by Hitler and his minions from 1929 until they came to power in 1933.
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Captivating History (History of Germany: A Captivating Guide to German History, Starting from 1871 through the First World War, Weimar Republic, and World War II to the Present (Exploring Germany’s Past))
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Quoted on page 50 of: JACK PARSONS ON HUMAN POPULATION COMPETITION A short synopsis of his major work by Edmund Davey
ISBN: 0-9541978-3-6
"No quantity of atom bombs could stem the tide of billions … who will someday … erupt [from] the poor southern part of the world … into the relatively accessible spaces of the rich Northern Hemisphere looking for survival."
President Boumedienne of Algeria.
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Houari Boumediene
Toby T. Arnold (EXPLORING THE MYSTERIES AND HORRORS OF POPPY PLAYTIME: A Comprehensive Synopsis)
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As already mentioned this novel was based on the two-part episode of the same name from The Saint, which starred Roger Moore; part one first aired on Sunday, 8 December 1968, and part two first aired on Sunday, 15 December 1968. The script was written by longtime favorite John Kruse with some minor adjustments by script editor Harry Junkin. Charteris loved the script, saying that “The Fiction Makers fulfils all the promise of the synopsis, and the dialogue has a crisp sparkle which has all too often been lacking in other scripts. It’s true that I still somewhat prefer the treatment of the ending which I suggested. But it is simply a splendid job.
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Leslie Charteris (The Saint and the Fiction Makers)
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Success is falling in love with the process, not the outcome. It’s making your dreams about the journey, about the “doing,” about the day-in-day-out routine and minutiae. The life you want is within the simplicity of your everyday tasks. You can’t only focus on writing the synopsis and then wonder why you don’t have a book yet.
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Brianna Wiest (101 Essays That Will Change The Way You Think)
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I offer this succinct synopsis of Bonhoeffer on the Christian life: We live in love by grace as the church-community—in, through, and toward Christ.
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Stephen J. Nichols (Bonhoeffer on the Christian Life: From the Cross, for the World)
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what the 21st century student of pathology needs is an organized, pithy, and easy-to-digest synopsis of the pertinent concepts and facts with specific links to the definitive material in a more expansive volume.
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Anonymous
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Söz konusu birleşme, sentezin birleştirici işlevi aracılığı ile gerçekleşmektedir. Sentezin, birleştirici işlevi, bilginin her iki öğesine de (görü ve kavram) ait olmakla birlikte, Heidegger, Kant’ın synopsis kendisinin ise syndosis olarak nitelendirdiği görünün, birlikteliğine vurgu yapmaktadır. Böylelikle Heidegger, anlamanın, birleştirici mantıksal bir işlevi olması yanında, nesne ile olan ilişkisine odaklamakta ve anlamanın, nesne ile ilişkisini kuran saf görüye yönelmektedir
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Anonymous
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Diğer yandan, syndosis Kant’ın kullandığı bir kavram değildir. Heidegger için, syndosis zaman ve uzamı sezgi olarak verendir. Bu nedenle, zaman ve uzam, öncelikle sezilebilen bir şey olarak açığa çıkar. Heidegger, bu yolla, zaman ve uzamın hem kendilerinde birer sezgi hem de sezginin formları olma ikilemini açıklığa kavuşturmuş olur: Birlik ya da zaman ve uzama ait tekliğin bütünlüğüne ait olan syndosis aracılığı ile zaman ve uzam, öncelikle, sezgi ya da arı sezilmiş olma biçiminde verilidir ve “sun”a ait olan bu birlik ve syndosis ya da synopsis sonuç olarak zaman-uzama aittir; anlamanın kavramlarına değil. Başka bir deyişle, syndosisin birliği, kavramlarda ve kategorilerde anlamanın sentezine ait olan bir birlik değildir (Heidegger 1965: 50).
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Anonymous
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Bu nedenle, Kant’ın B 160a’da sözünü ettiği sentez gerçek anlamda bir sentez değildir. Burada, duyulur sezgi çokluğunun birliği olarak sezginin arı formlarına yani zaman ve uzama ait olan sentez, kavramsal bir sentez olarak verilmektedir. B 160a’nın gönderimde bulunduğu sentez, synopsis’tir. Çünkü sentez, daha önce irdelendiği gibi, farklı öğeleri bir kavram altında bir araya getirme, birleştirme anlamına geliyorken, synopsis ‘tek’liğin (tek olmanın) verdiği kökensel birliği anlatır.
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Anonymous