Strong Genes Quotes

Weak people believe what is forced on them. Strong people what they wish to believe, forcing that to be real.

The story of Doubting Thomas is told, not so that we shall admire Thomas, but so that we can admire the other apostles in comparison. Thomas demanded evidence … The other apostles, whose faith was so strong that they did not need evidence, are held to us as worthy of imitation.

It may be that the only reason childhood memories act on us so strongly is that, being the most remote we possess, they are the worst remembered and so offer the least resistance to that process by which we mold them nearer and nearer to an ideal which is fundamentally artistic, or at least nonfactual.

History repeats itself, in part because the genome repeats itself. And the genome repeats itself, in part because history does. The impulses, ambitions, fantasies, and desires that drive human history are, at least in part, encoded in the human genome. And human history has, in turn, selected genomes that carry these impulses, ambitions, fantasies, and desires. This self-fulfilling circle of logic is responsible for some of the most magnificent and evocative qualities in our species, but also some of the most reprehensible. It is far too much to ask ourselves to escape the orbit of this logic, but recognizing its inherent circularity, and being skeptical of its overreach, might protect the week from the will of the strong, and the 'mutant' from being annihilated by the 'normal'.

The necropolis has never seemed a city of death to me; I know its purple roses (which other people think so hideous) shelter hundreds of small animals and birds. The executions I have seen performed and have performed myself so often are no more than a trade, a butchery of human beings who are for the most part less innocent and less valuable than cattle. When I think of my own death, or the death of someone who has been kind to me, or even of the death of the sun, the image that comes to my mind is that of the nenuphar, with its glossy, pale leaves and azure flower. Under flower and leaves are black roots as fine and strong as hair, reaching down into the dark waters.

Cheers to strong genes.

Boy, there are people who conquered half the world, slaughtered whole populations, wiped cultures off the face of the planet, and you know what history calls them? Heroes! Kings, presidents, champions, explorers. You think America was settled by white men because the Indians invited us her? No, we took this land because we were stronger, and that's how every page of human history is written. It's just our nature. We're a predator species, top of the food chain. Survival of the fittest is written in our blood, it's stenciled on every gene of our DNA. The strong take and the strong make, and the weak are there only to help them do it. End of story.

It is a dangerous thing with brothers, to think that you could be as strong as them, or as wise as them, or as good as them. To believe that you could have been the same person, if only you hadn’t gone a different way. To think that your parents raised you the same, and that your genes combined the same, and that the rest of what has happened in all your triumph . . . or failure.

Aidan pulled away and stared intently at her. His blue eyes blazed with intensity. “Listen to me. You have every right to be scared, but I want you to believe me when I say that Noah is going to be fine. He’s blessed with some strong as hell genes.” Placing his hand on her belly, he smiled. “He’s part Fitzgerald, and for generations, the men of my family have been known for being tough, scrappy fighters with a will of iron to survive.” “Really?” she questioned with a hiccup. Aidan nodded. “But even more than the fighting Irish Fitzgerald blood pumping through him, he’s inherited the most amazing DNA from his mother. She’s the strongest person I’ve ever known.

We talk of strong personalities, and they are strong, until the not-every-day when we see them as we might see one woman alone in a desert, and know that all the strength we thought we knew was only courage, only her lone song echoing among the stones; and then at last when we have understood this and made up our minds to hear the song and admire its courage and its sweetness, we wait for the next note and it does not come. The last word, with its pure tone, echoes and fades and is gone, and we realize—only then—that we do not know what it was, that we have been too intent on the melody to hear even one word. We go then to find the singer, thinking she will be standing where we last saw her. There are only bones and sand and a few faded rags.

And then there was that key point in On the Origin of Species. That crucial point that somehow both David and before him Francis Galton had missed. What does Darwin say is the best way of building a strong species, of allowing it to endure into the future, to withstand the blows of Chaos in all her mighty forms—flood, drought, rising sea levels, fluctuating temperatures, invasions of competitors, predators, pests? Variation. Variation in genes, and hence in behavior and physical traits. Homogeneity is a death sentence. To rid a species of its mutants and outliers is to make that species dangerously vulnerable to the elements.

... I believe in some sense much akin to the belief of faith, that I noticed, felt, or underwent what I describe—but it may be that the only reason childhood memories act on us so strongly is that, being the most remote we possess, they are the worst remembered and so offer the least resistance to that process by which we mold them nearer and nearer to an ideal which is fundamentally artistic, or at least nonfactual; so it may be that some of these events I describe never occurred at all, but only should have, and that others had not the shades and flavors—for example, of jealousy or antiquity or shame—that I have later unconsciously chosen to give them...

Everyone thinks that it was the big strong caveman who got the girl, and for the most part, that may have been true, but physical strength doesn't explain how our species created civilization. I think there was always some scrawny dreamer sitting at the edge of the firelight, who had the ability to imagine dangers, to look into the future in his imagination and see possibilities, and therefore survived to pass his genes on to the next generation. When the big ape men ended up running off the cliff or getting killed while trying to beat a mastodon into submission with a stick, the dreamer was standing back thinking 'Hey, that might work, but you need to run the mastodon off the cliff.' And, then he'd mate with the women left over after the go-getters got killed.

We can now give you a biological reason why cramming doesn’t work,” says Dr. Tully. The best way to prepare for a final exam is to mentally review the material periodically during the day, until the material becomes part of your long-term memory. This may also explain why emotionally charged memories are so vivid and can last for decades. The CREB repressor gene is like a filter, cleaning out useless information. But if a memory is associated with a strong emotion, it can either remove the CREB repressor gene or increase levels of the CREB activator gene.

So why the stress?" said Gene. “You have had sex before?” “Of course,” I said. “My doctor is strongly in favor.” “Frontiers of medical science,” said Gene. He was probably making a joke. I think the value of regular sex has been known for some time. I explained further. “It’s just adding a second person makes it complicated.

I miss you.” “It’s been less than twenty-four hours since you last saw me.” “The addiction gene runs strong in my family. Take pity on your husband.

When we die there are two things we can leave behind us: genes and memes. We were built as gene machines, created to pass on our genes. But that aspect of us will be forgotten in three generations. Your child, even your grandchild, may bear a resemblance to you, perhaps in facial features, in a talent for music, in the colour of her hair. But as each generation passes, the contribution of your genes is halved. It does not take long to reach negligible proportions. Our genes may be immortal but the collection of genes that is any one of us is bound to crumble away. Elizabeth II is a direct descendant of William the Conqueror. Yet it is quite probable that she bears not a single one of the old king’s genes. We should not seek immortality in reproduction. But if you contribute to the world’s culture, if you have a good idea, compose a tune, invent a sparking plug, write a poem, it may live on, intact, long after your genes have dissolved in the common pool. Socrates may or may not have a gene or two alive in the world today, as G. C. Williams has remarked, but who cares? The memecomplexes of Socrates, Leonardo, Copernicus and Marconi are still going strong.

There should be no romanticism that international public opinion or even international diplomatic and economic pressure can defeat a coup without determined and strong defense by the attacked society itself

For example, if (as Dawkins argues) deceit is fundamental in animal communication, then there must be strong selection to spot deception and this ought, in turn, to select for a degree of self-deception, rendering some facts and motives unconscious so as not to betray—by the subtle signs of self-knowledge—the deception being practiced.

Consider it this way: We are the descendants of frightened people. Early humans whose amygdala reacted to potential dangers and produced a strong fear response were most likely to behave in cautious ways and be protective of their children, which meant they were more likely to survive and pass their genes (and frightened amygdala) on to future generations.

The gene,” Dr. Narcejac-Boileau said, “is associated with social dominance and strong control over other people. We have isolated it in sports leaders, CEOs, and heads of state. We believe the gene is found in all dictators throughout history.

In fact, like other personality traits, personal happiness appears to be strongly influenced by our genes. Studies of identical and fraternal twins show that identical twins are significantly more likely to exhibit the same level of happiness than are fraternal twins or other siblings. Behavior geneticists have used these studies to estimate just how much genes matter, and their best guess is that long-term happiness depends 50 percent on a person’s genetic set point, 10 percent on their circumstances (e.g., where they live, how rich they are, how healthy they are), and 40 percent on what they choose to think and do.31

Mandalorians are surprisingly unconcerned with biological lineage. Their definition of offspring or parent is more by relationship than birth: adoption is extremely common, and it’s not unusual for soldiers to take war orphans as their sons or daughters if they impress them with their aggression and tenacity. They also seem tolerant of marital infidelity during long separations, as long as any child resulting from it is raised by them. Mandalorians define themselves by culture and behavior alone. It is an affinity with key expressions of this culture—loyalty, strong self-identity, emphasis on physical endurance and discipline—that causes some ethnic groups such as those of Concord Dawn in particular to gravitate toward Mandalorian communities, thereby reinforcing a common set of genes derived from a wide range of populations. The instinct to be a protective parent is especially dominant. They have accidentally bred a family-oriented warrior population, and continue to reinforce it by absorbing like-minded individuals and groups.

There have been many times when I have felt I have gone mad, for I have had many great adventures, and the greatest adventures are those that act most strongly upon our minds.

It was a strong clue that one key difference between expert and novice athletes was in the way they had learned to perceive the game, rather than the raw ability to react quickly.

It’s good to have strong opinions about gene engineering in humans, but it’s even better if you know what a gene is.

In psychology experiments, women strongly prefer ugly men wearing Rolexes to handsome men wearing Burger King uniforms.

If you are dyslexic, then any of your siblings has a 50 percent chance of also suffering from dyslexia, thus pointing to the strong genetic determinism of this developmental disorder. At least four genes have now been implicated in dyslexia—and interestingly, most of these genes affect the ability of neurons to migrate to their final locations in the cortex during pregnancy.

If genes strongly influence average levels of a trait, that trait is strongly inherited. If genes strongly influence the extent of variability around that average level, that trait has high heritability.

Weak people believe what is forced on them. Strong people what they wish to believe, forcing that to be real. What is the Autarch but a man who believes himself Autarch and makes others believe by the strength of it?

You wouldn’t understand, of course, but the bond between a mother and child, it’s . . . how best to describe it . . . unbreakable. The two of us are linked forever, you see—same blood in my veins that’s running through yours. You grew inside me, your teeth and your tongue and your cervix are all made from my cells, my genes. Who knows what little surprises I left growing inside there for you, which codes I set running? Breast cancer? Alzheimer’s? You’ll just have to wait and see. You were fermenting inside me for all those months, nice and cozy, Eleanor. However hard you try to walk away from that fact, you can’t, darling, you simply can’t. It isn’t possible to destroy a bond that strong.

They’re all after snaring a guy who works at the same company and won’t even look at me. Women have been like that since the Stone Age. The youngest, prettiest girls in the village go to the strongest hunters. They leave strong genes, while the rest of us just have to console ourselves with what’s left. Our so-called modern society is just an illusion. We’re living a world that has hardly changed since prehistoric times. We might go on about equality of the sexes, but—

For example, there are five successive studies of criminal behavior cited in my 1982 book. They show that if a man in prison has an identical twin, it’s likely his cotwin will also be in prison. If the twin is fraternal [with 50 percent shared genes, on average], the likelihood is not nearly as great that he’ll be in prison, too, but it’s greater than chance. How could one possibly account for this difference with environmentalist explanations? The strong genetic component in criminality has already been proven up to the hilt.

Exploring Self-Compassion Through Letter Writing PART ONE Everybody has something about themselves that they don’t like; something that causes them to feel shame, to feel insecure or not “good enough.” It is the human condition to be imperfect, and feelings of failure and inadequacy are part of the experience of living. Try thinking about an issue that tends to make you feel inadequate or bad about yourself (physical appearance, work or relationship issues, etc.). How does this aspect of yourself make you feel inside—scared, sad, depressed, insecure, angry? What emotions come up for you when you think about this aspect of yourself? Please try to be as emotionally honest as possible and to avoid repressing any feelings, while at the same time not being melodramatic. Try to just feel your emotions exactly as they are—no more, no less. PART TWO Now think about an imaginary friend who is unconditionally loving, accepting, kind, and compassionate. Imagine that this friend can see all your strengths and all your weaknesses, including the aspect of yourself you have just been thinking about. Reflect upon what this friend feels toward you, and how you are loved and accepted exactly as you are, with all your very human imperfections. This friend recognizes the limits of human nature and is kind and forgiving toward you. In his/her great wisdom this friend understands your life history and the millions of things that have happened in your life to create you as you are in this moment. Your particular inadequacy is connected to so many things you didn’t necessarily choose: your genes, your family history, life circumstances—things that were outside of your control. Write a letter to yourself from the perspective of this imaginary friend—focusing on the perceived inadequacy you tend to judge yourself for. What would this friend say to you about your “flaw” from the perspective of unlimited compassion? How would this friend convey the deep compassion he/she feels for you, especially for the discomfort you feel when you judge yourself so harshly? What would this friend write in order to remind you that you are only human, that all people have both strengths and weaknesses? And if you think this friend would suggest possible changes you should make, how would these suggestions embody feelings of unconditional understanding and compassion? As you write to yourself from the perspective of this imaginary friend, try to infuse your letter with a strong sense of the person’s acceptance, kindness, caring, and desire for your health and happiness. After writing the letter, put it down for a little while. Then come back and read it again, really letting the words sink in. Feel the compassion as it pours into you, soothing and comforting you like a cool breeze on a hot day. Love, connection, and acceptance are your birthright. To claim them you need only look within yourself.

There is a significant hereditary contribution to ADD but I do not believe any genetic factor is decisive in the emergence of ADD traits in any child. Genes are codes for the synthesis of the proteins that give a particular cell its characteristic structure and function. They are, as it were, alive and dynamic architectural and mechanical plans. Whether the plan becomes realized depends on far more than the gene itself. It is determined, for the most part, by the environment. To put it differently, genes carry potentials inherent in the cells of a given organism. Which of multiple potentials become expressed biologically is a question of life circumstances. Were we to adopt the medical model — only temporarily, for the sake of argument — a genetic explanation by itself would still be unsuitable. Medical conditions for which genetic inheritance are fully or even mostly responsible, such as muscular dystrophy, are rare. “Few diseases are purely genetic,” says Michael Hayden, a geneticist at the University of British Columbia and a world-renowned researcher into Huntington’s disease. “The most we can say is that some diseases are strongly genetic.” Huntington’s is a fatal degeneration of the nervous system based on a single gene that, if inherited, will almost invariably cause the disease. But not always. Dr. Hayden mentions cases of persons with the gene who live into ripe old age without any signs of the disease itself. “Even in Huntington’s, there must be some protective factor in the environment,” Dr. Hayden says.

It does not seem ever to have been satisfactorily answered why the two first operational atomic bombs were used—against the strongly voiced wishes of the leading physicists responsible for developing them—to destroy two cities instead of being deployed in the equivalent of spectacularly shooting out candles.

If circumstances require that your sleep habits depart from the earth’s natural light and dark cycles, make a strong effort to sleep with an eye mask (check mindfold.com for a total darkness sleep mask) in a completely darkened room, since all of your skin cells are sensitive and responsive to light—not just your eyes.

Why is it that medical strictures and recommendations so often work in favor of food processors and against food producers? Why, for example, do we so strongly favor the pasteurization of milk to health and cleanliness in milk production? (Gene Logsdon correctly says that the motive here "is monopoly, not consumer's health.")

From an outside viewpoint it seems as if I had almost all a man could ask in reason. But when was a strong man in the grip of love ever reasonable? I think the Almighty took a pretty grave responsibility when He made men as He did. If I had been He, and understood the forces I was handling, I would have been too big a coward to do it.

Regular consumption of fish has been shown to exert a strong anti-inflammatory effect, reduce risk for heart disease, help protect against asthma in children, moderate chronic lung disease, reduce the risk of breast and other cancers by stunting tumor growth, and ease the symptoms of rheumatoid arthritis and certain bone and joint diseases.

I AM NOT SO INTELLIGENT The epiphany I had in my career in randomness came when I understood that I was not intelligent enough, nor strong enough, to even try to fight my emotions. Besides, I believe that I need my emotions to formulate my ideas and get the energy to execute them. I am just intelligent enough to understand that I have a predisposition to be fooled by randomness—and to accept the fact that I am rather emotional. I am dominated by my emotions—but as an aesthete, I am happy about that fact. I am just like every single character whom I ridiculed in this book. Not only that, but I may be even worse than them because there may be a negative correlation between beliefs and behavior (recall Popper the man). The difference between me and those I ridicule is that I try to be aware of it. No matter how long I study and try to understand probability, my emotions will respond to a different set of calculations, those that my unintelligent genes want me to handle. If my brain can tell the difference between noise and signal, my heart cannot. Such unintelligent behavior does not just cover probability and randomness. I do not think I am reasonable enough to avoid getting angry when a discourteous driver blows his horn at me for being one nanosecond late after a traffic light turns green. I am fully aware that such anger is self-destructive and offers no benefit, and that if I were to develop anger for every idiot around me doing something of the sort, I would be long dead. These small daily emotions are not rational. But we need them to function properly. We are designed to respond to hostility with hostility. I have enough enemies to add some spice to my life, but I sometimes wish I had a few more (I rarely go to the movies and need the entertainment). Life would be unbearably bland if we had no enemies on whom to waste efforts and energy.

Vaccinations are the application of evolutionary principles in action. If we can control the contact made between pathogen and lymphocyte populations, we can go a long way toward eliminating disease.108 It doesn’t require total annihilation but rather a control on population dynamics. Vaccines are the way we use selective cloning to keep a pathogenic population in a state of benign coexistence. The process is based on evolution, as pointed out by Nobel laureate Susumu Tonegawa: “Genes can mutate and recombine. These dynamic characteristics of genetic material are essential elements of evolution. Do they also play an important role during the development of a single multicellular organism? Our results strongly suggest that this is the case for the immune system.

Doudna wrote in a scholarly publication back in 2013, researchers hoped to find ways to use RNA interference to protect humans from infections.6 Two papers published in Science that year gave strong evidence that it might work. The hope then was that drugs based on RNA interference might someday be a good option for treating severe viral infections, including those from new coronaviruses

If you want to predict how happy someone is, or how long she will live (and if you are not allowed to ask about her genes or personality), you should find out about her social relationships. Having strong social relationships strengthens the immune system, extends life (more than does quitting smoking), speeds recovery from surgery, and reduces the risks of depression and anxiety disorders. It’s not just that extroverts are naturally happier and healthier; when introverts are forced to be more outgoing, they usually enjoy it and find that it boosts their mood. Even people who think they don’t want a lot of social contact still benefit from it. And it’s not just that “we all need somebody to lean on”; recent work on giving support shows that caring for others is often more beneficial than is receiving help. We need to interact and intertwine with others; we need the give and the take; we need to belong. An ideology of extreme personal freedom can be dangerous because it encourages people to leave homes, jobs, cities, and marriages in search of personal and professional fulfillment, thereby breaking the relationships that were probably their best hope for such fulfillment.

Faith cannot move mountains (though generations of children are solemnly told the contrary and believe it). But it is capable of driving people to such dangerous folly that faith seems to me to qualify as a kind of mental illness. It leads people to believe in whatever it is so strongly that in extreme cases they are prepared to kill and to die for it without the need for further justification.

There are a small number of debilitating conditions with a strong genetic basis, such as muscular dystrophy or Huntington’s disease. These are rare, affecting about one person in ten thousand or even fewer. They do not pose a significant threat to the survival of the species. If, however, we add up the numbers of people plagued by depression or ADD or the other common psychological problems people in this society struggle with, including alcoholism and anxiety, we will have identified no less than a third of the North American population. Genetic explanations for these conditions assume that after millions of years of evolution, nature would permit a very large number of disordered genes, handicapping a third of humankind, to pass through the screen of natural selection — a highly unlikely proposition.

After a while you learn the subtle difference between holding a hand and chaining a soul and you learn that love doesn’t mean leaning and company doesn’t always mean security. And you begin to learn that kisses aren’t contracts and presents aren’t promises and you begin to accept your defeats with your head up and your eyes ahead with the grace of a woman, not the grief of a child and you learn to build all your roads on today because tomorrow’s ground is too uncertain for plans and futures have a way of falling down in mid-flight. After a while you learn that even sunshine burns if you get too much. So you plant your own garden and decorate your own soul instead of waiting for someone to bring you flowers. And you learn that you really can endure, that you really are strong and you really do have worth. and you learn and you learn with every good-bye you learn.

Sex and love – I have only just realised how very different they are. Sex says spread your seed as widely as possible. Love says put all your eggs in one special basket. Sex says me, me, me: love says you, you, you. Sex says muscle in on all the best-looking genes you can find. Love says search for that one unforgettable face. Sex says move on, find someone new. Love says don’t let anyone or anything take her away. Sex, you see, is biology. But love is chemistry.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

The year 1968 was also ground zero for popular music in Germany. Karl Bartos, in 1968 a 16-year-old gifted classical musician, puts it like this: ‘We don’t have the blues in our genes and we weren’t born in the Mississippi Delta. There were no black people in Germany. So instead we thought we’d had this development in the twenties which was very, very strong and was audio-visual. We had the Bauhaus school before the war; and then after the war we had tremendous people like Karlheinz Stockhausen and the development of the classical and the electronic classical. This was very strong and it all happened very close to Düsseldorf, in Cologne, and all the great composers at that time came there. During the late forties up until the seventies they all came to Germany; people like John Cage, Pierre Boulez and Pierre Schaeffer, and they all had this fantastic approach to modern music, and we felt it would make more sense to see Kraftwerk as part of that tradition more than anything else.

A second later, Douglas Bruce entered. Rushing to Leslie he caught her to his breast roughly, while with a strong hand he pressed her ear against his heart. ‘Now you listen, my girl!’ he cried, ‘Listen at close range.’ Leslie remained quiet a long second, then she lifted her face: adorable misty-eyed, and tenderly smiling. ‘Douglas, I never listened to a heart before. How do I know what it is saying? I can’t tell whether it is talking about me, or protesting against the way you’ve rushed around.

Kellogg School of Management Professor Camelia Kuhnen has found that the variation of a dopamine-regulating gene (DRD4) associated with a particularly thrill-seeking version of extroversion is a strong predictor of financial risk-taking. By contrast, people with a variant of a serotonin-regulating gene linked to introversion and sensitivity take 28 percent less financial risk than others. They have also been found to outperform their peers when playing gambling games calling for sophisticated decision-making.

Kellogg School of Management Professor Camelia Kuhnen has found that the variation of a dopamine-regulating gene (DRD4) associated with a particularly thrill-seeking version of extroversion is a strong predictor of financial risk-taking. By contrast, people with a variant of a serotonin-regulating gene linked to introversion and sensitivity take 28 percent less financial risk than others. They have also been found to outperform their peers when playing gambling games calling for sophisticated decision-making.

I thought it very likely I might have this sort of untestable power myself. It was kind of logical--no good at sport, alrightish at my studies, there must have been some field in which I excelled. Magic had to be it. It's difficult for adults to picture just what a grip these fantasies can take on a child. There's occasionally a reminder as a kid throws himself off a roof pretending to be Batman, but mostly the interior life of children goes unnoticed. When I say I thought I could be a wizard, that's exactly true. I really did believe I had latent magical powers, and, with enough concentration and fiddling my fingers into strange patterns, I might suddenly find how to unlock the magic inside me. I wouldn't call this a delusion, more a very strong suspicion. I'd weighed all the evidence, and that was the likely conclusion--so much so that I had to stop myself trying to turn Matt Bradon into a fly when he was jumping up and down on the desk in French saying, "Miss, what are mammary glands?" to the big-breasted Miss Mundsley. I feared that, if I succeeded, I might not be able to turn him back. It was important, I knew, to use my powers wisely. There's nothing that you'd have to call a psychoanalyst in for here. At the bottom line my growing interest in fantasy was just an expression of a very common feeling--"there's got to be something better than this," an easy one to have in the drab Midlands of the 1970s. I couldn't see it, though. My world was very small, and I couldn't imagine making things better incrementally, only a total escape.

My Fellow Non-American Blacks: In America, You Are Black, Baby Dear Non-American Black, when you make the choice to come to America, you become black. Stop arguing. Stop saying I’m Jamaican or I’m Ghanaian. America doesn’t care. So what if you weren’t “black” in your country? You’re in America now. We all have our moments of initiation into the Society of Former Negroes. Mine was in a class in undergrad when I was asked to give the black perspective, only I had no idea what that was. So I just made something up. And admit it—you say “I’m not black” only because you know black is at the bottom of America’s race ladder. And you want none of that. Don’t deny now. What if being black had all the privileges of being white? Would you still say “Don’t call me black, I’m from Trinidad”? I didn’t think so. So you’re black, baby. And here’s the deal with becoming black: You must show that you are offended when such words as “watermelon” or “tar baby” are used in jokes, even if you don’t know what the hell is being talked about—and since you are a Non-American Black, the chances are that you won’t know. (In undergrad a white classmate asks if I like watermelon, I say yes, and another classmate says, Oh my God that is so racist, and I’m confused. “Wait, how?”) You must nod back when a black person nods at you in a heavily white area. It is called the black nod. It is a way for black people to say “You are not alone, I am here too.” In describing black women you admire, always use the word “STRONG” because that is what black women are supposed to be in America. If you are a woman, please do not speak your mind as you are used to doing in your country. Because in America, strong-minded black women are SCARY. And if you are a man, be hyper-mellow, never get too excited, or somebody will worry that you’re about to pull a gun. When you watch television and hear that a “racist slur” was used, you must immediately become offended. Even though you are thinking “But why won’t they tell me exactly what was said?” Even though you would like to be able to decide for yourself how offended to be, or whether to be offended at all, you must nevertheless be very offended. When a crime is reported, pray that it was not committed by a black person, and if it turns out to have been committed by a black person, stay well away from the crime area for weeks, or you might be stopped for fitting the profile. If a black cashier gives poor service to the non-black person in front of you, compliment that person’s shoes or something, to make up for the bad service, because you’re just as guilty for the cashier’s crimes. If you are in an Ivy League college and a Young Republican tells you that you got in only because of Affirmative Action, do not whip out your perfect grades from high school. Instead, gently point out that the biggest beneficiaries of Affirmative Action are white women. If you go to eat in a restaurant, please tip generously. Otherwise the next black person who comes in will get awful service, because waiters groan when they get a black table. You see, black people have a gene that makes them not tip, so please overpower that gene. If you’re telling a non-black person about something racist that happened to you, make sure you are not bitter. Don’t complain. Be forgiving. If possible, make it funny. Most of all, do not be angry. Black people are not supposed to be angry about racism. Otherwise you get no sympathy. This applies only for white liberals, by the way. Don’t even bother telling a white conservative about anything racist that happened to you. Because the conservative will tell you that YOU are the real racist and your mouth will hang open in confusion.

When changes in one genetic trait are the source of selection for changes in a second, the rate of response in the latter depends in parts on the rate of change in the former, which, as a rule, is not fast. In comparison, if a cultural practice modifies selection acting on human genetic variation, then the greater the proportion of individuals in the population that exhibit the cultural trait, the stronger the selection on the gene. As a consequence, the rapid spread of a cultural practice often leads quickly to the maximally strong selection of the advantageous genetic variant, which rapidly increases in frequency. Cultural practices typically spread more quickly than genetic mutations, simply because cultural learning typically operates at faster rates than biological evolution. What does the speed with which a culturla trait spreads depend upon? Answer: the fidelity of cultural transmission. The very factor that is critical to the emergence of complex cumulative culture in humans is also a major determinant of evolutionary responses to that culture.

If you wish to succeed with healthy dietary habits, it’s important that you discard any negative emotions you have toward eating and embrace each meal as an opportunity to enjoy yourself. I strongly recommend that you give yourself permission to eat as much as you want, whenever you want, for the rest of your life. While this suggestion might scare the heck out of you, releasing yourself from restriction and deprivation enables you to become more connected with your physical nutritional needs rather than being driven by emotional triggers.

But it may be that the only reason childhood memories act on us so strongly is that, being the most remote we possess, they are the worst remembered and so offer the least resistance to that process by which we mold them nearer and nearer to an ideal which is fundamentally artistic, or at least nonfactual; so it may be that some of these events I describe never occurred at all, but only should have, and that others had not the shades and flavors—for example, of jealousy or antiquity or shame—that I have later unconsciously chosen to give them.

Different mechanisms underlie short- and long-term memory storage. A single sensory neuron from the siphon skin connects to a motor neuron that innervates the gill. Short-term memory is produced by a single shock to the tail. This activates modulatory neurons (in blue) that cause a functional strengthening of the connections between the sensory and motor neurons. Long-term memory is produced by five repeated shocks to the tail. This activates the modulatory neurons more strongly and leads to the activation of CREB-1 genes and the growth of new synapses.

Furthermore, some researchers have suggested a strong association with the presence of the protective gene in populations who have historically farmed yams. To plant yams, farmers clear forests. Cleared forest means more standing water. More standing water means more mosquitoes. More mosquitoes means more malaria—so the idea goes. The emergence of the disease, and as a consequence the resistance gene, may well have been enabled, or at least nurtured, by yam farming. The persistence of sickle cell anemia is the cost of positive selection for resistance against the most destructive disease in our history.

This system can indicate that this mouse is John Smith. How does it also tell that he’s your never-before-encountered brother? The closer the relative, the more similar their cluster of MHC genes and the more similar their olfactory signature. Olfactory neurons in a mouse contain receptors that respond most strongly to the mouse’s own MHC protein. Thus, if the receptor is maximally stimulated, it means the mouse is sniffing its armpit. If near maximally stimulated, it’s a close relative. Moderately, a distant relative. Not at all (though the MHC protein is being detected by other olfactory receptors), it’s a hippo’s

I wasn't sure which part of me was the smart one anymore. Maybe, for the first time, I realized that consistency, a trait I had long esteemed, was sometimes not such a virtue after all. Spontaneity was coming up fast down the stretch. When you get to this stage, of course you'll flail at first. After all, look what you're up against. But if you start to live in the present now, not only do you get to enjoy it (which is huge), but you also prepare yourself for the future, which someday will be your present, breathing in your face. If you've practiced, you'll be able to live there. You'll have that muscle. It will be strong.

In the environment in which we evolved, the careful choice of a mate was critical to a female’s success in passing on her genes. If her man was not strong enough to be a successful hunter, or not of sufficiently high rank within the tribe to commandeer food from others, her children might be in trouble. The women who were reproductively successful were those with a sexual preference for effective providers. A kind of erotic “tunnel vision” was selected for, which causes women to focus their mating effort on the men at the top of the pack — the “alpha males” with good physical endowments, social rank, and economic resources (or an ability to acquire them).

I had wonderful grandparents, and I promise you that I don't have any emotional scars from what happened with my mother." "Of course you do-anyone would! She walked out on you, then practically before your eyes lavished her attention on her next son..." "Stop it," he teased, "or you'll have me in tears." With quiet gravity Lauren said, "I was crying for the boy you were then, not for the man you are now. Despite everything that happened-no, because of it-you became a strong, independent man. Actually,the one to pity is your half brother." Nick chuckled. "You're right-he's an ass." Lauren ignored his humor. "What I meant was that you've succeeded on your own, without wealthy parents to help you. That makes you a bigger man than your half brother." "Is that why I'm bigger?" he joked. "I always thought it was in my genes. You see, my father and grandfather were both tall..." "Nick,I'm trying to be serious!" "Sorry.

One feature of our own society that seems decidedly anomalous is the matter of sexual advertisement, As we have seen, it is strongly to be expected on evolutionary grounds that, where the sexes differ, it should be the males that advertise and the females that are drab. Modern western man is undoubtedly exceptional in this respect. It is of course true that some men dress flamboyantly and some women dress drably but, on average, there can be no doubt that in our society the equivalent of the peacock's tail is exhibited by the female, not by the male. Women paint their faces and glue on false eyelashes. Apart from special cases, like actors, men do not. Women seem to be interested in their own personal appearance and are encouraged in this by their magazines and journals. Men's magazines are less preoccupied with male sexual attractiveness, and a man who is unusually interested in his own dress and appearance is apt to arouse suspicion, both among men and among women. When a woman is described in conversation, it is quite likely that her sexual attractiveness, or lack of it, will be prominently mentioned. This is true, whether the speaker is a man or a woman. When a man is described, the adjectives used are much more likely to have nothing to do with sex. Faced with these facts, a biologist would be forced to suspect that he was looking at a society in which females compete for males, rather than vice versa. In the case of birds of paradise, we decided that females are drab because they do not need to compete for males. Males are bright and ostentatious because females are in demand and can afford to be choosy. The reason female birds of paradise are in demand is that eggs are a more scarce resource than sperms. What has happened in modern western man? Has the male really become the sought-after sex, the one that is in demand, the sex that can afford to be choosy? If so, why?

This is honestly the best lasagna I've ever had, Lilian. I'm not sure how I ever get Rachel to come out for dinner when she could be eating here all the time." He smiled at Rachel, but my mother answered him. "It's lucky they inherited my good genes, isn't it, Richard? My girls may not have quite inherited my bone structure, but they both got my metabolism. I can eat like a horse and still stay a size one." She smiled. "I worry a little about Clare, though. She picked up her Dad's slightly chunkier build, didn't you, pudding?" Rachel caught my eye and looked horrified. I was silent, but it was only because I was building up a proper head of steam. Just as I was about to get to my feet and order her out of my life forever, Clare spoke up. "It's not about how big or small you are, Grandma, you know." She took another bite of lasagna, and talked around it. "It's about being strong and healthy. You need to eat plenty and run around a lot and drink lots of water and go to sleep early, that's what Mom says.

As the Harvard Gazette summarized in 2017: Close relationships, more than money or fame, are what keep people happy throughout their lives. . . . Those ties protect people from life’s discontents, help to delay mental and physical decline, and are better predictors of long and happy lives than social class, IQ, or even genes. That finding proved true across the board among both the Harvard men and the inner-city participants.[7] Men who’d had warm childhood relationships with their parents earned more as adults than men whose parent-child bonds were more strained. They were also happier and less likely to suffer dementia in old age. People with strong marriages suffered less physical pain and emotional distress over the course of their lives. Individuals’ close friendships were more accurate predictors of healthy aging than their cholesterol levels. Social support and connections to a community helped insulate people against disease and depression. Meanwhile, loneliness and disconnection, in some cases, were fatal.

When we die there are two things we can leave behind us: genes and memes. We were built as gene machines, created to pass on our genes. But that aspect of us will be forgotten in three generations. Your child, even your grandchild, may bear a resemblance to you, perhaps in facial features, in a talent for music, in the colour of her hair. But as each generation passes, the contribution of your genes is halved. It does not take long to reach negligible proportions. Our genes may be immortal but the collection of genes that is any one of us is bound to crumble away. Elizabeth II is a direct descendant of William the Conqueror. Yet it is quite probable that she bears not a single one of the old king’s genes. We should not seek immortality in reproduction. But if you contribute to the world’s culture, if you have a good idea, compose a tune, invent a sparking plug, write a poem, it may live on, intact, long after your genes have dissolved in the common pool. Socrates may or may not have a gene or two alive in the world today, as G. C. Williams has remarked, but who cares? The meme-complexes of Socrates, Leonardo, Copernicus, and Marconi are still going strong.

Hilda argued that our fate is more likely determined by what she called our “unique environment”—the one we do not share with anyone, not even our siblings. It is the environment we seek out and create for ourselves, for example, when we find something which delights and fascinates us and drives us in a certain direction. Rather like Blomkvist’s reaction as a young boy, perhaps, when he saw the film All the President’s Men and was struck by a strong urge to become a journalist. Heredity and environment interact constantly, Hilda wrote. We seek out occurrences and activities which stimulate our genes and make them flourish, and we avoid things which frighten us or make us uncomfortable. She based her conclusions on a series of studies, among others MISTRA, the Minnesota Study of Twins Reared Apart, and investigations by the Swedish Twin Registry at the Karolinska Institute. Identical twins, or so-called monozygotic twins, with their essentially indistinguishable sets of genes, are ideal subjects. Thousands of twins, both identical and fraternal, grow up apart from each other, either because one or both have been adopted, or, more rarely, as the result of some unfortunate mix-up in a maternity ward.

When studies using mental ability test scores from children are considered, the heritability of mental ability is typically found to be about .40, and the effect of the common or shared environment is found to be almost as strong, about .35. In contrast, when studies using mental ability test scores from adults (or older adolescents) are considered, estimates of the heritability of mental ability are much higher, typically about .65, whereas estimates of common or shared environment effects are much lower, probably under .20 (see review by Haworth et al., 2010). These findings indicate that differences among children in their levels of mental ability are attributable almost as much to their common environment—that is, to features of their family or household circumstances—as to their genetic inheritances. However, the findings also suggest that as children grow up, the differences among them in mental ability become less strongly related to the features of their common environments, and more strongly related to their genetic inheritances. In other words, the effect on one's mental ability of the family or household in which one is reared tends to become less important as one grows up, so that by adulthood one's level of mental ability is heavily dependent on one's genetic characteristics. It is as if one's level of mental ability—relative to that of other persons of the same age—can be raised (or lowered) during childhood by a particularly good (or poor) home environment, but then gradually returns to the level that one's genes tend to produce.

One of our best dates was actually a weekend when we went to the wedding of a friend from the Teams. The couple married in Wimberley, Texas, a small town maybe forty miles south of Austin and a few hours’ drive from where we lived. We were having such a pleasant day, we didn’t want it to end. “It doesn’t have to end,” suggested Chris as we headed for the car. “The kids are at my parents’ for the weekend. Where do you want to go?” We googled for hotels and found a place in San Antonio, a little farther south. Located around the corner from the Alamo, the hotel seemed tailor-made for Chris. There was history in every floorboard. He loved the authentic Texan and Old West touches, from the lobby to the rooms. He read every framed article on the walls and admired each artifact. We walked through halls where famous lawmen-and maybe an outlaw or two-had trod a hundred years before. In the evening, we relaxed with coffee out on the balcony of our room-something we’d never managed to do when we actually owned one. It was one of those perfect days you dream of, completely unplanned. I have a great picture of Chris sitting out there in his cowboy boots, feet propped up, a big smile on his face. It’s still one of my favorites. People ask about Chris’s love of the Old West. It was something he was born with, really. It had to be in his genes. He grew up watching old westerns with his family, and for a time became a bronco-bustin’ cowboy and ranch hand. More than that, I think the clear sense of right and wrong, of frontier justice and strong values, appealed to him.

The first result of this randomized trial was predictable from prior studies: in the control group, children with the short variant-i.e., the "high risk" form of the gene- were twice as likely to veer toward high-risk behaviors, including binge drinking, drug use, and sexual promiscuity as adolescents, confirming earlier studies that had suggested an increased risk within this genetic subgroup. The second result was more provocative: these very children were also the most likely to respond to the social interventions. In the intervention group, children with the high-risk allele were most strongly and rapidly "normalized"-i.e., the most drastically affected subjects were also the best responders. In a parallel study, orphaned infants with the short variant of 5HTTLRP appeared more impulsive and socially disturbed than their long-variant counterparts as baseline-but were also the most likely to benefit from placement in a more nurturing foster-care environment. In both cases, it seems, the short variant encodes a hyperactive "stress sensor" for psychic susceptibility, but also a sensor most likely to respond to an intervention that targets the susceptibility. The most brittle or fragile forms of psyche are the most likely to be distorted by trauma-inducing environments-but are also the most likely to be restored by targeted interventions. It is as if resilience itself has a genetic core: some humans are born resilient (but are less responsive to interventions), while others are born sensitive (but more likely to respond to changes in their environments.)

We have looked at some of the things that a female might do if she has been deserted by her mate. But these all have the air of making the best of a bad job. Is there anything a female can do to reduce the extent to which her mate exploits her in the first place? She has a strong card in her hand. She can refuse to copulate. She is in demand, in a seller's market. This is because she brings the dowry of a large, nutritious egg. A male who successfully copulates gains a valuable food reserve for his offspring. The female is potentially in a position to drive a hard bargain before she copulates. Once she has copulated she has played her ace — her egg has been committed to the male. It is all very well to talk about driving hard bargains, but we know very well it is not really like that. Is there any realistic way in which something equivalent to driving a hard bargain could evolve by natural selection? I shall consider two main possibilities, called the domestic-bliss strategy, the he-man strategy. The simplest version of the domestic-bliss strategy is this. The female looks the males over, and tries to spot signs of fidelity and domesticity in advance. There is bound to be variation in the population of males in their predisposition to be faithful husbands. If females could recognize such qualities in advance, they could benefit themselves by choosing males possessing them. One way for a female to do this is to play hard to get for a long time, to be coy. Any male who is not patient enough to wait until the female eventually consents to copulate is not likely to be a good bet as a faithful husband. By insisting on a long engagement period, a female weeds out casual suitors, and only finally copulates with a male who has proved his qualities of fidelity and perseverance in advance. Feminine coyness is in fact very common among animals, and so are prolonged courtship or engagement periods. As we have already seen, a long engagement can also benefit a male where there is a danger of his being duped into caring for another male's child.

Scientists have found that there are two important genes, the CREB activator (which stimulates the formation of new connections between neurons) and the CREB repressor (which suppresses the formation of new memories). Dr. Jerry Yin and Timothy Tully of Cold Spring Harbor have been doing interesting experiments with fruit flies. Normally it takes ten trials for them to learn a certain task (e.g., detecting an odor, avoiding a shock). Fruit flies with an extra CREB repressor gene could not form lasting memories at all, but the real surprise came when they tested fruit flies with an extra CREB activator gene. They learned the task in just one session. “This implies these flies have a photographic memory,” says Dr. Tully. He said they are just like students “who could read a chapter of a book once, see it in their mind, and tell you that the answer is in paragraph three of page two seventy-four.” This effect is not just restricted to fruit flies. Dr. Alcino Silva, also at Cold Spring Harbor, has been experimenting with mice. He found that mice with a defect in their CREB activator gene were virtually incapable of forming long-term memories. They were amnesiac mice. But even these forgetful mice could learn a bit if they had short lessons with rest in between. Scientists theorize that we have a fixed amount of CREB activator in the brain that can limit the amount we can learn in any specific time. If we try to cram before a test, it means that we quickly exhaust the amount of CREB activators, and hence we cannot learn any more—at least until we take a break to replenish the CREB activators. “We can now give you a biological reason why cramming doesn’t work,” says Dr. Tully. The best way to prepare for a final exam is to mentally review the material periodically during the day, until the material becomes part of your long-term memory. This may also explain why emotionally charged memories are so vivid and can last for decades. The CREB repressor gene is like a filter, cleaning out useless information. But if a memory is associated with a strong emotion, it can either remove the CREB repressor gene or increase levels of the CREB activator gene. In the future, we can expect more breakthroughs in understanding the genetic basis of memory. Not just one but a sophisticated combination of genes is probably required to shape the enormous capabilities of the brain. These genes, in turn, have counterparts in the human genome, so it is a distinct possibility that we can also enhance our memory and mental skills genetically. However, don’t think that you will be able to get a brain boost anytime soon. Many hurdles still remain. First, it is not clear if these results apply to humans.

Sex thus represents a defending mechanism of long-term biodiversity, versus cloning that would trend strongly toward competition. Although competitive traits never go away, their intensity and distribution are moderated, and sexuality powerfully lowers the curve of increasing aggressive tendency within any species. Sex as a key principle of biotic intimacy is a safety valve in nature against an ultimate, self-destructive integrity of aggressive replicators that would diminish life's complexity and turn evolutionary expression toward a brutish simplicity. In the long run, sex may protect against the threat of bottlenecking gene pools with populations envisioned by Tennyson-"red in tooth and claw"-having impoverished endowment for survival in a world of change on many fronts.

So far, the smallest memory device known to be evolved and used in the wild is the genome of the bacterium Candidatus Carsonella ruddii, storing about 40 kilobytes, whereas our human DNA stores about 1.6 gigabytes, comparable to a downloaded movie. As mentioned in the last chapter, our brains store much more information than our genes: in the ballpark of 10 gigabytes electrically (specifying which of your 100 billion neurons are firing at any one time) and 100 terabytes chemically/biologically (specifying how strongly different neurons are linked by synapses). Comparing these numbers with the machine memories shows that the world’s best computers can now out-remember any biological system—at a cost that’s rapidly dropping and was a few thousand dollars in 2016.

Let’s first consider how farming led to natural selection. It bears repeating that the very first farmers lived about 600 to 500 generations ago, and in most parts of the world, farming has been practiced for less than 300 generations. From an evolutionary perspective, this is not much time for lots of major evolutionary change, such as a new species evolving, but it is enough time for genes with strong effects on survival and reproduction to change their frequencies appreciably within populations. In fact, because farming so profoundly altered people’s diets, the pathogens they encountered, the work they did, and the number of children they could have, the origins of agriculture probably intensified selection on certain genes.

I really have no idea why they gave me the genes of such strong people if they wanted me to shut up and sit back and do as I’m told without any arguments what-so-ever. They really are idiots.   The

The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.

The increased risk for bipolar illness among identical twins is even true if the identical twins are separated at birth and raised by different families. Although the adoption of identical twins by separate families is rare, it does happen on occasion. In some cases, scientists have been able to locate the twins later in life to determine how similar or different they are. These "natural" experiments can tell us a great deal about the relative importance of genes versus environment because the separately raised identical twins have identical genes but their environments are different. Such studies highlight the importance of strong genetic influences in bipolar disorder.

The Neanderthals were a proto-species, an embryonic light that flickered in evolutionary time, but was not strong enough to stand across epochs.

I drive away those who pay to see me by foretelling their futures, and I will foretell yours. You are young now, and strong. But before the world has wound itself ten times more about the sun you shall be less strong, and you shall never regain the strength that is yours now. If you breed sons, you will engender enemies against yourself. If--" "Enough!" I said. "What you are telling me is only the fortune of all men.

When studies using mental ability test scores from children are considered, the heritability of mental ability is typically found to be about .40, and the effect of the common or shared environment is found to be almost as strong, about .35. In contrast, when studies using mental ability test scores from adults (or older adolescents) are considered, estimates of the heritability of mental ability are much higher, typically about .65, whereas estimates of common or shared environment effects are much lower, probably under .20 (see review by Haworth et al., 2010). These findings indicate that differences among children in their levels of mental ability are attributable almost as much to their common environment—that is, to features of their family or household circumstances—as to their genetic inheritances. However, the findings also suggest that as children grow up, the differences among them in mental ability become less strongly related to the features of their common environments, and more strongly related to their genetic inheritances. In other words, the effect on one's mental ability of the family or household in which one is reared tends to become less important as one grows up, so that by adulthood one's level of mental ability is heavily dependent on one's genetic characteristics. It is as if one's level of mental ability—relative to that of other persons of the same age—can be raised (or lowered) during childhood by a particularly good (or poor) home environment, but then gradually returns to the level that one's genes tend to produce. The aforementioned findings are based mainly on samples of participants who belong to the broad middle class of modern Western countries. There is some evidence, though, that the heritability of IQ tends to be somewhat lower (at least until young adulthood, and perhaps beyond) when studies are conducted using participants of less enriched environments, such as those in economically underdeveloped countries or in the lowest socioeconomic classes of some Western countries (see review by Nisbett et al., 2012). One recent study (Tucker-Drob & Bates, 2016) found that in the United States, additive genetic influences had a weaker influence on IQ among persons of low socioeconomic status than among persons of high socioeconomic status. (Interestingly, Tucker-Drob and Bates did not find this effect in western European countries or in Australia, where socioeconomic status differences tend to be smaller.) The above findings suggest that whenever the heritability of IQ is discussed, it is important to consider the ages of the persons being examined as well as their socioeconomic status and their country.

The way circus elephants are trained demonstrates this dynamic well: When young, they are attached by heavy chains to large stakes driven deep into the ground. They pull and yank and strain and struggle, but the chain is too strong, the stake too rooted. One day they give up, having learned that they cannot pull free, and from that day forward they can be “chained” with a slender rope. When this enormous animal feels any resistance, though it has the strength to pull the whole circus tent over, it stops trying. Because it believes it cannot, it cannot. “You’ll never amount to anything;” “You can’t sing;” “You’re not smart enough;” “Without money, you’re nothing;” “Who’d want you?;” “You’re just a loser;” “You should have more realistic goals;” “You’re the reason our marriage broke up;” “Without you kids I’d have had a chance;” “You’re worthless”—this opera is being sung in homes all over America right now, the stakes driven into the ground, the heavy chains attached, the children reaching the point they believe they cannot pull free. And at that point, they cannot. Unless and until something changes their view, unless they grasp the striking fact that they are tied with a thread, that the chain is an illusion, that they were fooled, and ultimately, that whoever so fooled them was wrong about them and that they were wrong about themselves—unless all this happens, these children are not likely to show society their positive attributes as adults. There’s more involved, of course, than just parenting. Some of the factors are so small they cannot be seen and yet so important they cannot be ignored: They are human genes. The one known as D4DR may influence the thrill-seeking behavior displayed by many violent criminals. Along with the influences of environment and upbringing, an elongated D4DR gene will likely be present in someone who grows up to be an assassin or a bank robber (or a daredevil). Behavioral geneticist Irving Gottesman: “Under a different scenario and in a different environment, that same person could become a hero in Bosnia.” In the future, genetics will play a much greater role in behavioral predictions. We’ll probably be able to genetically map personality traits as precisely as physical characteristics like height and weight. Though it will generate much controversy, parents may someday be able to use prenatal testing to identify children with unwanted personality genes, including those that make violence more likely. Until then, however, we’ll have to settle for a simpler, low-tech strategy for reducing violence: treating children lovingly and humanely.

Mind, all minds, whether brilliant or dull, are equipped with a simple and instinctual survival tool that is, "Repeat pleasure and avoid pain." This enables us to avoid putting our hands in the fire twice or continually trying to quench our thirst with sea water. The converse of "nasty" implying danger is that "nice" or pleasurable implies the opposite, which is a survival advantage. You can see this most strongly in sexual reproduction. If the sexual act were unpleasant, it would hardly favor the propagation of either our individual genes or the species in general.

About one-half of the human population carries these genes, while the other half does not, making the first half much more dangerous indeed. It’s not even a contest. The overwhelming majority of prisoners carry these genes, as do 98.4 percent of those on death row. It seems clear enough that the carriers are strongly predisposed toward a different type of behavior—and these statistics alone indicate that we cannot presume that everyone is coming to the table equally equipped in terms of drives and behaviors.

Secularism in the twentieth century has not proven it can give moral guidance to technology or the state. Many intuit faintly or strongly that we human beings and our loves and aspirations cannot be reduced to matter, chemistry, and genes.

On a good day, he bore a strong resemblance to Gene Hackman. On an average day, a wax sculpture of Gene Hackman from Madame Tussauds. On a bad day, a ghoulish funeral effigy of Gene Hackman from an underground chamber of horrors.

personality traits, and these have a strong genetic component.69 Your genes seem to be an important part of how sunny your outlook is on life. How important? About 50 or 60 percent.

Joan Joyce is the real deal, a fierce competitor and one of the greatest athletes and coaches in sports history. Tony Renzoni’s moving tribute to Joan shows us why she is a champion in sports and in life. —Billie Jean King, sports icon and equality pioneer The story is all true. Joan Joyce was a tremendous pitcher, as talented as anyone who ever played. [responding to a newspaper account of his early 1960s match-ups against Joan Joyce] —Ted Williams, Hall of Famer and Boston Red Sox great, December 30, 1999 Joan Joyce is truly the greatest female athlete in sports history. And a great coach as well. Tony Renzoni’s well-researched book is a touching tribute to this phenomenal athlete. I highly recommend this book! —Bobby Valentine, former MLB player and manager Quotes for Historic Connecticut Music Venues: From the Coliseum to the Shaboo: I would like to thank Tony Renzoni for giving me the opportunity to write the foreword to his wonderful book. I highly recommend Connecticut Music Venues: From the Coliseum to Shaboo to music lovers everywhere! —Felix Cavaliere, Legendary Hall of Famer (Young Rascals/Rascals, Solo) As the promoter of the concerts in many of the music venues in this book, I hope you enjoy living the special memories this book will give you. —Jim Koplik, Live Nation president, Connecticut and Upstate New York Tony Renzoni has captured the soul and spirit of decades of the Connecticut live music scene, from the wild and wooly perspective of the music venues that housed it. A great read! —Christine Ohlman, the “Beehive Queen,” recording artist/songwriter Tony Renzoni has written a very thoughtful and well-researched tribute to the artists of Connecticut, and we are proud to have Gene included among them. —Lynne Pitney, wife of Gene Pitney Our Alice Cooper band recorded the Billion Dollars Babies album in a mansion in Greenwich. Over the years, there have been many great musicians from Connecticut, and the local scene is rich with good music. Tony Renzoni’s book captures all of that and more. Sit back and enjoy the ride. —Dennis Dunaway, hall of famer and co-founder of the Alice Cooper band. Rock ’n’ Roll music fans from coast to coast will connect to events in this book. Strongly recommended! —Judith Fisher Freed, estate of Alan Freed

mutations in the gene that carries the code for the protein filaggrin were strongly associated with eczema.11 Filaggrin is essential for the integrity of the barrier

In an extreme example, the Russian scientist Dmitri Belyaev succeeded in developing a domesticated fox in only forty years.5 In each generation he selected for tameness (and only tame- ness); this eventually resulted in foxes that were friendly and enjoyed human contact, in strong contrast to wild foxes. This strain of tame foxes also changed in other ways: Their coat color lightened, their skulls became rounder, and some of them were born with floppy ears. It seems that some of the genes influenc- ing behavior (tameness in this case) also affect other traits—so when Belyaev selected for tameness, he automatically got changes in those other traits as well. Many of these changes have occurred as side effects of domestication in a number of species—possibly including humans, as we shall see.

As was she, her father had passed her many of his features. So, I must assume their gene pool was just that strong.

She might simply have done what Tekla did, and created versions of herself modified for certain traits associated with athleticism. Instead, having become fascinated by the odd detail in her genetic report, she had embarked on a program to reawaken the Neanderthal DNA that, or so she imagined, had been slumbering in her and her ancestors’ nuclei for tens of thousands of years. It was a somewhat insane idea, and in any case she didn’t have enough Neanderthal in her to make it feasible, but she did produce a race of people with vaguely Neanderthal-like features, and in later centuries the processes of Caricaturization, Isolation, and Enhancement—which had affected all the races to some extent—had wrought especially pronounced changes on this subrace. Gene sequences taken from the toe of an actual Neanderthal skeleton, found on Old Earth and sequenced before Zero, were put to use. Old Earth paleontology journals had been data-mined for stats on bone length and muscle attachment so that those could be hard-coded into the Neoander wetware. The man sitting at the end of the table was the artificial product of breeding and of genetic engineering, but, had he been sent back in time to prehistoric Europe, he would have been indistinguishable, at least in his outward appearance, from genuine Neanderthals. The creation of the new race had happened incrementally, over centuries. By the time Neoanders existed it was too late to bother with the trifling ethical question of whether it was really a good thing to have created them. During their slow differentiation from the other races they had developed a history and a culture of their own, of which they were as proud as any other ethnic group. Not surprisingly, much of that history was about their relationship with Teklans, which was, as foreordained, largely combative. At its most simple-minded and stupidly reductionist bones, the Teklan side of the story was that Neoanders were dangerous ape-men brought into existence by a crazy Eve as a curse upon the other six races. The Neoander side had it that Teklans were what Hitler would have produced if he’d had genetic engineering labs, and that it was a damned good thing that Eve Aïda had had the foresight to produce a countervailing force of earthy, warm, but immensely strong and dangerous protectors. Much of this combative relationship had become irrelevant as the tactical landscape had become dominated by katapults and ambots, and physical strength had become less important to the outcome of fights. But the old primordial animus remained, and explained why Beled’s immediate response, upon entering a room that contained a Neoander, was to make himself ready for hand-to-hand combat. Doc chose to ignore this. If he even notices, Kath Two thought, but she was pretty sure Doc noticed everything. “Beled, Kath, I do not believe you have met Langobard.” It was a fairly common Aïdan name. “Bard for short,” Langobard offered. “Langobard, may I present Beled Tomov and Kath Amalthova Two.

A hundred years of further studies have confirmed Durkheim’s diagnosis. If you want to predict how happy someone is, or how long she will live (and if you are not allowed to ask about her genes or personality), you should find out about her social relationships. Having strong social relationships strengthens the immune system, extends life (more than does quitting smoking), speeds recovery from surgery, and reduces the risks of depression and anxiety disorders.53 It’s not just that extroverts are naturally happier and healthier; when introverts are forced to be more outgoing, they usually enjoy it and find that it boosts their mood.54 Even people who think they don’t want a lot of social contact still benefit from it. And it’s not just that “we all need somebody to lean on”; recent work on giving support shows that caring for others is often more beneficial than is receiving help.55 We need to interact and intertwine with others; we need the give and the take; we need to belong.

Some of the normal histones are removed altogether. Histone H2A is replaced by a related but subtly different molecule called macroH2A, strongly associated with gene repression.

What holds cells in this teetering position? In 2006, a group headed by Eric Lander at the Broad Institute in Boston, found at least part of the answer. A key set of genes in ES cells, the pluripotent cells we have come to know so well, were found to have a really strange histone modification pattern. These were genes that were very important for controlling if an ES cell stayed pluripotent, or differentiated. Histone H3K4 was methylated at these genes, which normally is associated with switching on gene expression. H3K27 was also methylated. This is normally associated with switching off gene expression. So, which modification would turn out to be stronger? Would the genes be switched on or off? The answer turned out to be both. Or neither, depending on which way we look at it. These genes were in a state called ‘poised’. Given the slightest encouragement – a change in culture conditions that pushed cells towards differentiation for example – one or other of these methylations was lost. The gene was fully switched on, or strongly repressed, depending on the epigenetic modification

BRCA-1, a gene that strongly predisposes humans to breast and ovarian cancer.

Regular consumption of fish has been shown to exert a strong anti-inflammatory effect, reduce risk for heart disease, help protect against asthma in children, moderate chronic lung disease, reduce the risk of breast and other cancers by stunting tumor growth, and ease the symptoms of rheumatoid arthritis and certain bone and joint diseases. Nursing and pregnant women enjoy a host of benefits from fish consumption, including support for fetal and early childhood brain and retinal development and a lowered risk of premature birth.

A creed that tells us that we are no more than selfish genes, with nothing in principle to separate us from the animals, in a society whose strongest motivators are money and success, in a universe that came into existence for no reason whatsoever and for no reason will one day cease to be, will never speak as strongly to the human spirit as one that tells us we are in the image and likeness of God in a universe he created in love.