Rare Diseases Quotes

An algorithm that expedites care to a stroke patient in a chaotic emergency room (ER) has a good chance of adoption. An algorithm that reads a routine scan and provides some quantification of what the physicians can already estimate won’t be in as much demand. There are good reasons for algorithms to parse patient records to look for signs of rare diseases, but there are fewer good reasons for using them to evaluate clinical symptoms. It’s cool that AI tools can make diagnoses from scratch, but for most clinical encounters doctors are already pretty good at it.

Used in combination with genomics, AI could help pharma companies to develop new drugs for rare diseases. The rarer a disease is, the smaller the market is and so the less likely it is to have been addressed. Big pharma is hesitant to take on the high development costs for new drugs if there’s no sign of a return on investment. Biological processes are complex, and that means that they lead to multidimensional data that human beings struggle to wrap their heads around. The good news is that AI is the perfect tool to spot patterns in this kind of data.

Dante laughed. "No cold soup, no goat cheese. I'll make a mental note. And no Gottfried Curse." "And for you it's no food at all. No sleep. And no tunnels." "I'm low maintenance." "Is that what you are? Because I've been trying to figure it out all semester." "And what have you concluded?" "A mutant. A rare disease. A creature from the inferno. Dante." "And what if you found out you were right?" he asked. "What if it meant that I could hurt you?" "I would say that I'm not scared. Everyone has the ability to hurt. It's the choice that matters.

It’s estimated that AI could free up to 25% of clinician time across different specialties. This increased amount of time could mean less hurried encounters and more humane interactions, including more empathy from happier doctors. This is important because empathy has been shown to improve outcomes by boosting patient adherence to the prescribed treatments, increasing motivation, and reducing anxiety and stress.

I often wished that more people understood the invisible side of things. Even the people who seemed to understand, didn't really.

It is extraordinarily entertaining to watch the historians of the past ... entangling themselves in what they were pleased to call the "problem" of Queen Elizabeth. They invented the most complicated and astonishing reasons both for her success as a sovereign and for her tortuous matrimonial policy. She was the tool of Burleigh, she was the tool of Leicester, she was the fool of Essex; she was diseased, she was deformed, she was a man in disguise. She was a mystery, and must have some extraordinary solution. Only recently has it occrurred to a few enlightened people that the solution might be quite simple after all. She might be one of the rare people were born into the right job and put that job first.

Let me claim that Africa and I kept company for a while and then parted ways as if we were both party to relations with a failed outcome. Or say I was afflicted with Africa like a bout of a rare disease from which I have not managed a full recovery.

Not only rationality, but individuality too is a myth. Humans rarely think for themselves. Rather, we think in groups. Just as it takes a tribe to raise a child, it also takes a tribe to invent a tool, solve a conflict, or cure a disease. No individual knows everything it takes to build a cathedral, an atom bomb, or an aircraft. What gave Homo sapiens an edge over all other animals and turned us into the masters of the planet was not our individual rationality but our unparalleled ability to think together in large groups.1

I had learned quickly that life doesn't always go the way I want it to, and that's okay. I still plod on.

…I once found a list of diseases as yet unclassified by medical science, and among these there occurred the word Islomania, which was described as a rare but by no means unknown affliction of spirit. There are people…who find islands somehow irresistible. The mere knowledge that they are on an island, a little world surrounded by the sea, fills them with an indescribable intoxication. These born “islomanes”…are direct descendents of the Atlanteans

Samaritrophia is only a disease, and a violent one, too, when it attacks those exceedingly rare individuals who reach biological maturity still loving and wanting to help their fellow men.

She had come to understand that American parenting was a juggling of anxieties, and that it came with having too much food: a sated belly gave Americans time to worry that their child might have a rare disease that they had just read about, made them think that they had the right to protect their child from disappointment and want and failure. A sated belly gave Americans the luxury of praising themselves for being good parents, as if caring for one’s child were the exception rather than the rule.

Sorry. I get attacks of quotitis every once in a while. It's a very rare disease with no cure. It usually attacks older people, and here i am afflicted with it at my tender age.

This form of interspecies leap is common, not rare; about 60 percent of all human infectious diseases currently known either cross routinely or have recently crossed between other animals and us.

The strong, ferocious wind just made the chill worse, and as it blew around me, electric bursts of pain shot through my body.

There's nothing like saying goodbye to a place to make you want to stay. Everywhere I look I see memories I've made, good and bad, and it hurts. I feel as though I've been afflicted by some rare disease that renders me incapable of seeing an object, place or person for what it is right now, and instead forces me to remember what it has been or wonder what it might become in my absence. It's like a kind of pre-emptive grief.

The self-healing power of the body is often overlooked because it is rarely given a chance to act in a world that expects the quick fix.

I picked up a rare disease called conscience" .... "That can often turn fatal.

The fundamental answer to why so many humans are now getting sick from previously rare illnesses is that many of the body's features were adapted in environments from which we evolved, but have become maladapted in the modern environments we have now created. This idea, known as the mismatch hypothesis, is the core of the new emerging field of evolutionary medicine, which applies evolutionary biology to health and disease.

When I went on my first antidepressant it had the side effect of making me fixated on suicide (which is sort of the opposite of what you want). It’s a rare side effect so I switched to something else that did work. Lots of concerned friends and family felt that the first medication’s failure was a clear sign that drugs were not the answer; if they were I would have been fixed. Clearly I wasn’t as sick as I said I was if the medication didn’t work for me. And that sort of makes sense, because when you have cancer the doctor gives you the best medicine and if it doesn’t shrink the tumor immediately then that’s a pretty clear sign you were just faking it for attention. I mean, cancer is a serious, often fatal disease we’ve spent billions of dollars studying and treating so obviously a patient would never have to try multiple drugs, surgeries, radiation, etc., to find what will work specifically for them. And once the cancer sufferer is in remission they’re set for life because once they’ve learned how to not have cancer they should be good. And if they let themselves get cancer again they can just do whatever they did last time. Once you find the right cancer medication you’re pretty much immune from that disease forever. And if you get it again it’s probably just a reaction to too much gluten or not praying correctly. Righ

(Researchers at the University of Iowa have for years been studying a woman, known in the literature as S.M., whose amygdala was destroyed by a rare disease—and who cannot, as a consequence, experience fear.)

It's something of a sacrilege nowadays to speak of insanity as anything but the chemical brain disease that on one level it is. But there were moments with my daughter when I had the distressed sense of being in the presence of a rare force of nature, such as a great blizzard or flood: destructive, but in its way astounding too. (4)

The weekend was a much-needed breath of fresh air; Monday always seemed to not only take that breath right back, but add a few extra pounds to my shoulders as well.

You will remember that Albertus Magnus, after describing minutely the process by which spirits may be invoked and commanded, adds emphatically that the process will instruct and avail only to the few - that a man must be born a magician! - that is, born with a peculiar physical temperament, as a man is born a poet. Rarely are men in whose constitution lurks this occult power of the highest order of intellect - usually in the intellect there is some twist, perversity, or disease.' ("The House And The Brain")

One reason chronic diseases are so rarely cured is that in many cases, essential curative steps make people miserable for a time, while steps that aggravate the disease make people feel better.

Insight: all evaluation is made from a definite perspective: that of the preservation of the individual, a community, a race, a state, a church, a faith, a culture.--- Because we forget that valuation is always from a perspective, a single individual contains within him a vast confusion of contradictory valuations and consequently of contradictory drives. This is the expression of the diseased condition in man, in contrast to the animals in which all existing instincts answer to quite definite tasks. This contradictory creature has in his nature, however, a great method of acquiring knowledge: he feels many pros and cons, he raises himself to justice---to comprehension beyond esteeming things good and evil. The wisest man would be the one richest in contradictions, who has, as it were, antennae for all types of men---as well as his great moments of grand harmony---a rare accident even in us! A sort of planetary motion---

He started to apologize for the fact that there were no chairs in his son's room--only floor cushions--but I quickly gave him to believe that for me this was little short of a godsend. (In fact, I think I said I hated chairs. I was so nervous that if he had informed me that his son's room was flooded, night and day, with a foot of water, I probably would have let out a little cry of pleasure. I probably would have said I had a rare foot disease, one that required my keeping my feet wet eight hours daily.)

Stanley’s Congo expedition fired the starting gun for the Scramble for Africa. Before his trip, white outsiders had spent hundreds of years nibbling at Africa’s edges, claiming land around the coastline, but rarely venturing inland. Disease, hostile tribes and the lack of any clear commercial potential in Africa meant that hundreds of years after white explorers first circumnavigated its coastline, it was still referred to in mysterious terms as the Dark Continent, a source of slaves, ivory and other goods, but not a place white men thought worthy of colonisation. It was Leopold’s jostling for the Congo that forced other European powers to stake claims to Africa’s interior, and within two decades the entire continent had effectively been carved up by the white man. The modern history of Africa – decades of colonial exploitation and post-independence chaos – was begun by a Telegraph reporter battling down the Congo River.

His face was still smarter and more spiritual than others, but it rarely laughed, and assumed, one after another, those features which are so often found in the faces of rich people, those features of discontent, of sickliness, of ill-humour, of sloth, of a lack of love. Slowly the disease of the soul, which rich people have, grabbed hold of him

Genes are rarely about inevitability, especially when it comes to humans, the brain, or behavior. They’re about vulnerability, propensities, tendencies

The video was still playing, although I didn't know why. It seemed as if the able-bodied dancers were mocking me.

We have much to learn about myopia, but two facts are clear. First, myopia is a formerly rare evolutionary mismatch that is exacerbated by modern environments. Second, even though we don’t entirely understand which factors cause children’s eyeballs to elongate too much, we do know how to treat the symptoms of myopia effectively with eyeglasses. Eyeglasses

We must love the Holy Spirit who breathed his healing books through a mortal vessel for all people of all race and gender to be healed and saved from demise. We must do away with hate, discrimination, abuse, malice, dissension, fraud and all injustice. This will enable sound healing for all people and this world will be healed from terminal, chronic and rare diseases, the Lord God Almighty, will remove all natural disasters and atrocities from happening. Other than that, there is no peace and salvation in this world.

If you don’t drink coffee, you should think about two to four cups a day. It can make you more alert, happier, and more productive. It might even make you live longer. Coffee can also make you more likely to exercise, and it contains beneficial antioxidants and other substances associated with decreased risk of stroke (especially in women), Parkinson’s disease, and dementia. Coffee is also associated with decreased risk of abnormal heart rhythms, type 2 diabetes, and certain cancers.12, 13 Any one of those benefits of coffee would be persuasive, but cumulatively they’re a no-brainer. An hour ago I considered doing some writing for this book, but I didn’t have the necessary energy or focus to sit down and start working. I did, however, have enough energy to fix myself a cup of coffee. A few sips into it, I was happier to be working than I would have been doing whatever lazy thing was my alternative. Coffee literally makes me enjoy work. No willpower needed. Coffee also allows you to manage your energy levels so you have the most when you need it. My experience is that coffee drinkers have higher highs and lower lows, energywise, than non–coffee drinkers, but that trade-off works. I can guarantee that my best thinking goes into my job, while saving my dull-brain hours for household chores and other simple tasks. The biggest downside of coffee is that once you get addicted to caffeine, you can get a “coffee headache” if you go too long without a cup. Luckily, coffee is one of the most abundant beverages on earth, so you rarely have to worry about being without it. Coffee costs money, takes time, gives you coffee breath, and makes you pee too often. It can also make you jittery and nervous if you have too much. But if success is your dream and operating at peak mental performance is something you want, coffee is a good bet. I highly recommend it. In fact, I recommend it so strongly that I literally feel sorry for anyone who hasn’t developed the habit.

There is a legend that elephant dispose of their dead in secret burial grounds and that none of these has ever been discovered. In support of this, there is only the fact that the body of an elephant, unless he had been trapped or shot in his tracks, has rarely been found. What happens to the old and diseased? Not only natives, but many white settlers, have supported for years the legend (if it is a legend) that elephant will carry their wounded and their sick hundreds of miles, if necessary, to keep them out of the hands of their enemies. And it is said that elephant never forget" (206).

there are about seven thousand rare diseases—so many that about one person in seventeen in the developed world has one, which isn’t very rare at all. But, sadly, so long as a disease affects only a small number of people, it is unlikely to get much research attention. For 90 percent of rare diseases, there are no treatments at all.

When I argue with devout statists, sometimes other voluntaryists tell me that I'm wasting my time, opining that a particular statist is never going to "get it." I often respond by saying that that's rarely my intention. Most of the time, when I argue with statists, the goal is for ME to learn more about the mentality and psychology of authoritarian indoctrination, and to hopefully help any SPECTATORS--whether statist or anarchist--learn something from the exchange. (Both of those goals can be achieved even if the statist continues to be a lunk-headed dupe.) Earlier today, a funny but possibly profound analogy came to mind about this: When I argue with "true believer" devout statists, I'm not being a doctor trying to heal an ailing patient; I'm being a coroner, doing an AUTOPSY on a patient who is already beyond any hope of saving, in the hopes that I, and anyone observing, may learn more about the "disease" of statism, in order to better understand the nature of it, and possibly prevent others from experiencing a similar fate.

Myocarditis is a rare, but potentially deadly disease

Bipolar disease is one of the rare instances where a predator and a victim can occupy the same body at the same time.

Dancing with a spinal cord injury is a challenge like no other, but I aspired to prove to myself that I could still be phenomenal dancer even with an SCI

Strangely, the subsequent AIDS works that have become iconic in our culture rarely mention the movement, or the engaged community of lovers, but both formations were inseparable from the crisis itself. Now, looking back, I fear that the story of the isolated helpless homosexual was one far more palatable to the corporations who control the reward system in the arts.The more truthful story of the American mass - abandoning families, criminal governments, indifferent neighbors - is too uncomfortable and inconvenient to recall. The story of how gay people who were despised, had no rights, and carried the burden of a terrible disease came together to force the country to change against its will, is apparently too implicating to tell. Fake tales of individual heterosexuals heroically overcoming their prejudices to rescue helpless dying men with AIDS was a lot more appealing to the powers that be, but not at all true.

I once had a doctor tell me there are a certain number of catastrophically bad things that, statistically speaking, must happen every year to a certain number of people—rare diseases, freak accidents, and, yes, serial killer attacks. Little grains of tragedy carried by the wind. I could make peace with the idea that one of those currents happened to catch my corner of the world.

hemophilia is an inherited blood-clotting deficiency, transmitted by women according to the sex-linked recessive Mendelian pattern. Thus, while women carry the defective genes, they almost never suffer from the disease. With rare exceptions, it strikes only males. Yet it does not necessarily strike all the males in a family. Genetically as well as clinically, hemophilia is capricious.

The Bible rarely tells me to fight against someone who doesn’t believe what I believe, but it frequently tells me to fight against my sin and the disease in me that’s drawing me away from Jesus.

Horned humans are not unknown to medical science as there is a rare skin disease, which goes by the name of ‘Cornu Cutaneum’, a cutaneous growth, which resembles a horn and grows from the scalp.

Josie suffers from a very rare disease," he said. "It's caused by a genetic mutation. But the good news is that researchers are working on a gene therapy that could correct the mutation. It's still in the experimental stage, but there's a good chance it'll work. If it does, Josie could be cured." And I wondered, as I often did these days, whether Artificial Friends could help with such work.

Rarely do I truly understand the disease which ails me. Therefore, rarely do I truly understand the fix that would cure me. And so maybe I should truly contemplate how rarely I recognize that God understands both.

Rune was taught that leprosy is rarely contagious. The causative bacterium lives in the environment, more so in unclean settings, but only those with unique susceptibility get the disease. He recalls Professor Mehr in Malmö dressing leprous wounds with impunity, saying, “Worry about other diseases you might get from your patients, not leprosy.” Indeed, Rune lost one classmate to tuberculosis, and another to sepsis from a scalpel cut.

Maybe she hated being out of control, knowing that someone or something else was dictating her fate. Because it's really not fair. A drunk driver runs a red light, and you end up dead. A guy in a movie theater coughs on you, and you catch some rare, fatal disease. You sit in class minding your own business, and there's the kid from sixth period holding a gun in his hand. Why should other people be in control? Why should someone else get to choose when you die?

There are cancers so insidious in their nature that their very pulsation is invisible. Such cancers leave the ivory whiteness of the skin untouched, and marble not the firm, fair flesh, with their blue tints; the physician who bends over the patient's chest hears not, through he listens, the insatiable teeth of the disease grinding its onward progress through the muscles, as the blood flows freely on; the knife has never been able to destroy, and rarely even, temporarily, to discern the rage of these mortal scourges; their home is in the mind, which they corrupt; they fill the whole heart until it breaks. Such, madame, are the cancers, fatal to queens; are you, too, free from their scourge?

The first step to take is to become aware that love is an art, just as living is an art; if we want to learn how to love we must proceed in the same way we have to proceed if we want to learn any other art, say music, painting, carpentry, or the art of medicine or engineering. What are the necessary steps in learning any art? The process of learning an art can be divided conveniently into two parts: one, the mastery of the theory; the other, the mastery of the practice. If I want to learn the art of medicine, I must first know the facts about the human body, and about various diseases. When I have all this theoretical knowledge, I am by no means competent in the art of medicine. I shall become a master in this art only after a great deal of practice, until eventually the results of my theoretical knowledge and the results of my practice are blended into one — my intuition, the essence of the mastery of any art. But, aside from learning the theory and practice, there is a third factor necessary to becoming a master in any art — the mastery of the art must be a matter of ultimate concern; there must be nothing else in the world more important than the art. This holds true for music, for medicine, for carpentry — and for love. And, maybe, here lies the answer to the question of why people in our culture try so rarely to learn this art, in spite of their obvious failures: in spite of the deep-seated craving for love, almost everything else is considered to be more important than love: success, prestige, money, power — almost all our energy is used for the learning of how to achieve these aims, and almost none to learn the art of loving.

Obviously, the more kids who are vaccinated, the better our country is protected and the less likely it is that any child will die from a disease. Some parents, however, aren't willing to risk the very rare side effects of vaccines, so they choose to skip the shots. Their children benefit from herd immunity (the protection of all the vaccinated kids around them) without risking the vaccines themselves. Is this selfish? Perhaps. But as parents you have to decide. Are you supposed to make decisions that are good for the country as a whole? Or do you base your decision on what's best for your own child as an individual? Can we fault parents for putting their own child's health ahead of the other kids' around him?

Vladimir Nabokov and George Orwell had quite different gifts, and their self-images were quite different. But, I shall argue, their accomplishment was pretty much the same. Both of them warn the liberal ironist intellectual against temptations to be cruel. Both of them dramatise the tension between private irony and liberal hope. In the following passage, Nabokov helped blur the distinctions which I want to draw: ...'Lolita' has no moral in tow. For me a work of fiction exists only in so far as it affords me what I shall bluntly call aesthetic bliss, that is a sense of being somehow, somewhere, connected with other states of being where art (curiosity, tenderness, kindness, ecstasy) is the norm. There are not many such books. All the rest is either topical trash or what some call the Literature of Ideas, which very often is topical trash coming in huge blocks of plaster that are carefully transmitted from age to age until somebody comes along with a hammer and takes a good crack at Balzac, at Gorki, at Mann. Orwell blurred the same distinctions when, in one of his rare descents into rant, "The Frontiers of Art and Propaganda," he wrote exactly the sort of thing Nabokov loathed: You cannot take a purely aesthetic interest in a disease you are dying from; you cannot feel dispassionately about a man who is about to cut your throat. In a world in which Fascism and Socialism were fighting one another, any thinking person had to take sides... This period of ten years or so in which literature, even poetry was mixed up with pamphleteering, did a great service to literary criticism, because it destroyed the illusion of pure aestheticism... It debunked art for art's sake.

He started to apologize for the fact that there were no chairs in his son's room -only floor cushions- but I quickly gave him to believe that for me this was little short of a godsend. (In fact, I think I said I hated chairs. I was so nervous that if he had informed me that his son's room was flooded, night and day, with a foot of water, I probably would have let out a little cry of pleasure. I probably would have said I had a rare foot disease, one that required my keeping my feet wet eight hours daily.)

What is today’s date? Who is the President? How great a danger do you pose, on a scale of one to ten? What does “people who live in glass houses” mean? Every symphony is a suicide postponed, true or false? Should each individual snowflake be held accountable for the avalanche? Name five rivers. What do you see yourself doing in ten minutes? How about some lovely soft Thorazine music? If you could have half an hour with your father, what would you say to him? What should you do if I fall asleep? Are you still following in his mastodon footsteps? What is the moral of “Mary Had a Little Lamb”? What about his Everest shadow? Would you compare your education to a disease so rare no one else has ever had it, or the deliberate extermination of indigenous populations? Which is more puzzling, the existence of suffering or its frequent absence? Should an odd number be sacrificed to the gods of the sky, and an even to those of the underworld, or vice versa? Would you visit a country where nobody talks? What would you have done differently? Why are you here?

In a section of The Vaccine Book titled “Is it your social responsibility to vaccinate your kids?” Dr. Bob asks, “Can we fault parents for putting their own child’s health ahead of that of the kids around him?” This is meant to be a rhetorical question, but Dr. Bob’s implied answer is not mine. In another section of the book, Dr. Bob writes of his advice to parents who fear the MMR vaccine, “I also warn them not to share their fears with their neighbors, because if too many people avoid the MMR, we’ll likely see the disease increase significantly.” I do not need to consult an ethicist to determine that there is something wrong there, but my sister clarifies my discomfort. “The problem is in making a special exemption just for yourself,” she says. This reminds her of a way of thinking proposed by the philosopher John Rawls: Imagine that you do not know what position you are going to hold in society—rich, poor, educated, insured, no access to health care, infant, adult, HIV positive, healthy immune system, etc.—but that you are aware of the full range of possibilities. What you would want in that situation is a policy that is going to be equally just no matter what position you end up in. “Consider relationships of dependence,” my sister suggests. “You don’t own your body—that’s not what we are, our bodies aren’t independent. The health of our bodies always depends on choices other people are making.” She falters for a moment here, and is at a loss for words, which is rare for her. “I don’t even know how to talk about this,” she says. “The point is there’s an illusion of independence.

If I’ve learned anything, it's that we know next to nothing. Disease is a mystery. Health is inscrutable. The body itself is scarcely understood; we can only examine the secrets of the dead. And in all that dark ignorance, we're sometimes granted a rare moment of illumination. The truth is a gift.

There is a significant hereditary contribution to ADD but I do not believe any genetic factor is decisive in the emergence of ADD traits in any child. Genes are codes for the synthesis of the proteins that give a particular cell its characteristic structure and function. They are, as it were, alive and dynamic architectural and mechanical plans. Whether the plan becomes realized depends on far more than the gene itself. It is determined, for the most part, by the environment. To put it differently, genes carry potentials inherent in the cells of a given organism. Which of multiple potentials become expressed biologically is a question of life circumstances. Were we to adopt the medical model — only temporarily, for the sake of argument — a genetic explanation by itself would still be unsuitable. Medical conditions for which genetic inheritance are fully or even mostly responsible, such as muscular dystrophy, are rare. “Few diseases are purely genetic,” says Michael Hayden, a geneticist at the University of British Columbia and a world-renowned researcher into Huntington’s disease. “The most we can say is that some diseases are strongly genetic.” Huntington’s is a fatal degeneration of the nervous system based on a single gene that, if inherited, will almost invariably cause the disease. But not always. Dr. Hayden mentions cases of persons with the gene who live into ripe old age without any signs of the disease itself. “Even in Huntington’s, there must be some protective factor in the environment,” Dr. Hayden says.

A woman’s body never really belongs to herself. As an infant, my body was my mother’s, a detachable extension of her own, a digestive passage clamped and unclamped from her body. My parents would watch over it, watch over what went in and out of it, and as I grew up I would be expected to carry on their watching by myself. Then there was sex, and a succession of years in which I trawled my body along behind me like a drift net, hoping that I wouldn’t catch anything in it by accident, like a baby or a disease. I had kept myself free of these things only through clumsy accident and luck. At rare and specific moments when my body was truly my own, I never knew what to do with it.

Two large trials of antioxidants were set up after Peto’s paper (which rather gives the lie to nutritionists’ claims that vitamins are never studied because they cannot be patented: in fact there have been a great many such trials, although the food supplement industry, estimated by one report to be worth over $50 billion globally, rarely deigns to fund them). One was in Finland, where 30,000 participants at high risk of lung cancer were recruited, and randomised to receive either ß-carotene, vitamin E, or both, or neither. Not only were there more lung cancers among the people receiving the supposedly protective ß-carotene supplements, compared with placebo, but this vitamin group also had more deaths overall, from both lung cancer and heart disease. The results of the other trial were almost worse. It was called the ‘Carotene and Retinol Efficacy Trial’, or ‘CARET’, in honour of the high p-carotene content of carrots. It’s interesting to note, while we’re here, that carrots were the source of one of the great disinformation coups of World War II, when the Germans couldn’t understand how our pilots could see their planes coming from huge distances, even in the dark. To stop them trying to work out if we’d invented anything clever like radar (which we had), the British instead started an elaborate and entirely made-up nutritionist rumour. Carotenes in carrots, they explained, are transported to the eye and converted to retinal, which is the molecule that detects light in the eye (this is basically true, and is a plausible mechanism, like those we’ve already dealt with): so, went the story, doubtless with much chortling behind their excellent RAF moustaches, we have been feeding our chaps huge plates of carrots, to jolly good effect. Anyway. Two groups of people at high risk of lung cancer were studied: smokers, and people who had been exposed to asbestos at work. Half were given 3-carotene and vitamin A, while the other half got placebo. Eighteen thousand participants were due to be recruited throughout its course, and the intention was that they would be followed up for an average of six years; but in fact the trial was terminated early, because it was considered unethical to continue it. Why? The people having the antioxidant tablets were 46 per cent more likely to die from lung cancer, and 17 per cent more likely to die of any cause,* than the people taking placebo pills. This is not news, hot off the presses: it happened well over a decade ago.

One last bit of bad news. We’ve been focusing on the stress-related consequences of activating the cardiovascular system too often. What about turning it off at the end of each psychological stressor? As noted earlier, your heart slows down as a result of activation of the vagus nerve by the parasympathetic nervous system. Back to the autonomic nervous system never letting you put your foot on the gas and brake at the same time—by definition, if you are turning on the sympathetic nervous system all the time, you’re chronically shutting off the parasympathetic. And this makes it harder to slow things down, even during those rare moments when you’re not feeling stressed about something. How can you diagnose a vagus nerve that’s not doing its part to calm down the cardiovascular system at the end of a stressor? A clinician could put someone through a stressor, say, run the person on a treadmill, and then monitor the speed of recovery afterward. It turns out that there is a subtler but easier way of detecting a problem. Whenever you inhale, you turn on the sympathetic nervous system slightly, minutely speeding up your heart. And when you exhale, the parasympathetic half turns on, activating your vagus nerve in order to slow things down (this is why many forms of meditation are built around extended exhalations). Therefore, the length of time between heartbeats tends to be shorter when you’re inhaling than exhaling. But what if chronic stress has blunted the ability of your parasympathetic nervous system to kick the vagus nerve into action? When you exhale, your heart won’t slow down, won’t increase the time intervals between beats. Cardiologists use sensitive monitors to measure interbeat intervals. Large amounts of variability (that is to say, short interbeat intervals during inhalation, long during exhalation) mean you have strong parasympathetic tone counteracting your sympathetic tone, a good thing. Minimal variability means a parasympathetic component that has trouble putting its foot on the brake. This is the marker of someone who not only turns on the cardiovascular stress-response too often but, by now, has trouble turning it off.

In my unfortunately infrequent encounters with real passion, I'm rarely as careful as I ought to be. The rationalization goes something like: With all the bullets and mortar rounds I've survived, I must be immune to sexually transmitted diseases. Stupid, I know. More likely, fate will indulge its taste for irony by killing me with AIDS os some other unpleasant alternative.

. . . for if we rarely taste the fulness of joy in this life, we yet more rarely savor the acrid bitterness of hopeless anguish; unless, strained, simulated, again overstrained, and, at last, destroyed our faculties for enjoyment; then, truly, we may find ourselves without support, robbed of hope. Our agony is great, and how can it end? We have broken the spring of our powers; life must be all suffering‐‐ too feeble to conceive faith‐‐death must be darkness‐‐God, spirits, religion can have no place in our collapsed minds, where linger only hideous and polluting recollections of vice; and time brings us on to the brink of the grave, and dissolution flings us in‐‐a rag eaten through and through with disease, wrung together with pain, stamped into the churchyard sod by the inexorable heel of despair.

There was a sage who was expert in herbal medicines. With great difficulty he once procured a rare seed which, as per his intuition, could cure any disease. He planted the seed. After 12 years of extreme hardwork, the tree yielded nothing but poisonous fruits. How could he let go of 12 years of investment? So he started nurturing the tree more and more in hope of turning it into the elixir it was supposed to be. The poison of tree started entering into his blood now. He was about to die. Luckily a disciple came to visit him and destroyed the tree. A couple of years later, during a casual walk into jungle, he found a full grown tree with fruits that could cure any disease. Let go of relationships or projects that turned out to be poisonous or dead. Your investment will come back to you in the form of luck.

The trait that astounded and confounded cynicism was his apparent unselfishness. Never, in any man who wielded such power, did Henry Adams meet anything like it. The effect of power and publicity on all men is the aggravation of self, a sort of tumor that ends by killing the victim's sympathies; a diseased appetite, like a passion for drink or perverted tastes; one can scarcely use expressions too strong to describe the violence of egotism it stimulates; and Turlow Weeds was one of the exceptions; a rare imune. He thought apparently not of himself, but of the person he was talking with. He held himself naturally in the background. He was not jealous. He grasped power, but not office. He distributed offices by handfuls without caring to take them. He had the instinct of empire: he gave, but he did not receive.

There is one in this tribe too often miserable - a child bereaved of both parents. None cares for this child: she is fed sometimes, but oftener forgotten: a hut rarely receives her: the hollow tree and chill cavern are her home. Forsaken, lost, and wandering, she lives more with the wild beast and bird than with her own kind. Hunger and cold are her comrades: sadness hovers over, and solitude besets her round. Unheeded and unvalued, she should die: but she both lives and grows: the green wilderness nurses her, and becomes to her a mother: feeds her on juicy berry, on saccharine root and nut. There is something in the air of this clime which fosters life kindly: there must be something, too, in its dews, which heals with sovereign balm. Its gentle seasons exaggerate no passion, no sense; its temperature tends to harmony; its breezes, you would say, bring down from heaven the germ of pure thought, and purer feeling. Not grotesquely fantastic are the forms of cliff and foliage; not violently vivid the colouring of flower and bird: in all the grandeur of these forests there is repose; in all their freshness there is tenderness. The gentle charm vouchsafed to flower and tree, - bestowed on deer and dove, - has not been denied to the human nursling. All solitary, she has sprung up straight and graceful. Nature cast her features in a fine mould; they have matured in their pure, accurate first lines, unaltered by the shocks of disease. No fierce dry blast has dealt rudely with the surface of her frame; no burning sun has crisped or withered her tresses: her form gleams ivory-white through the trees; her hair flows plenteous, long, and glossy; her eyes, not dazzled by vertical fires, beam in the shade large and open, and full and dewy: above those eyes, when the breeze bares her forehead, shines an expanse fair and ample, - a clear, candid page, whereon knowledge, should knowledge ever come, might write a golden record. You see in the desolate young savage nothing vicious or vacant; she haunts the wood harmless and thoughtful: though of what one so untaught can think, it is not easy to divine. On the evening of one summer day, before the Flood, being utterly alone - for she had lost all trace of her tribe, who had wandered leagues away, she knew not where, - she went up from the vale, to watch Day take leave and Night arrive. A crag, overspread by a tree, was her station: the oak-roots, turfed and mossed, gave a seat: the oak-boughs, thick-leaved, wove a canopy. Slow and grand the Day withdrew, passing in purple fire, and parting to the farewell of a wild, low chorus from the woodlands. Then Night entered, quiet as death: the wind fell, the birds ceased singing. Now every nest held happy mates, and hart and hind slumbered blissfully safe in their lair. The girl sat, her body still, her soul astir; occupied, however, rather in feeling than in thinking, - in wishing, than hoping, - in imagining, than projecting. She felt the world, the sky, the night, boundlessly mighty. Of all things, herself seemed to herself the centre, - a small, forgotten atom of life, a spark of soul, emitted inadvertent from the great creative source, and now burning unmarked to waste in the heart of a black hollow. She asked, was she thus to burn out and perish, her living light doing no good, never seen, never needed, - a star in an else starless firmament, - which nor shepherd, nor wanderer, nor sage, nor priest, tracked as a guide, or read as a prophecy? Could this be, she demanded, when the flame of her intelligence burned so vivid; when her life beat so true, and real, and potent; when something within her stirred disquieted, and restlessly asserted a God-given strength, for which it insisted she should find exercise?

The most convincing data concern rare humans with damage restricted to the amygdala, either due to a type of encephalitis or a congenital disorder called Urbach-Wiethe disease, or where the amygdala was surgically destroyed to control severe, drug-resistant seizures originating there.5 Such individuals are impaired in detecting angry facial expressions (while being fine at recognizing other emotional states—stay tuned).

The fundamental answer to why so many humans are now getting sick from previously rare illnesses is that many of the body’s features were adaptive in the environments for which we evolved but have become maladaptive in the modern environments we have now created. This idea, known as the mismatch hypothesis, is the core of the new, emerging field of evolutionary medicine, which applies evolutionary biology to health and disease.17

But what lies ahead for those who are young now? I can say with confidence that their future will depend more on science and technology than any previous generation’s has done. They need to know about science more than any before them because it is part of their daily lives in an unprecedented way. Without speculating too wildly, there are trends we can see and emerging problems that we know must be dealt with, now and into the future. Among the problems I count global warming, finding space and resources for the massive increase in the Earth’s human population, rapid extinction of other species, the need to develop renewable energy sources, the degradation of the oceans, deforestation and epidemic diseases—just to name a few. There are also the great inventions of the future, which will revolutionise the ways we live, work, eat, communicate and travel. There is such enormous scope for innovation in every area of life. This is exciting. We could be mining rare metals on the Moon, establishing a human outpost on Mars and finding cures and treatments for conditions which currently offer no hope. The huge questions of existence still remain unanswered—how did life begin on Earth? What is consciousness? Is there anyone out there or are we alone in the universe? These are questions for the next generation to work on.

a twenty-year study that tracked six thousand British civil servants found that when their bosses criticized them unfairly, didn’t listen to their problems, and rarely praised them, employees suffered more angina, heart attacks, and deaths from heart disease. You get the idea. It doesn’t matter whether the assholes around you are getting ahead or (more likely) screwing up their lives, careers, and companies. They pose a danger to you and others.

It's curious to note that the miracles performed by an "all-loving" and benevolent God so often involve sparing a handful of people from a tragic accident, devastating disaster or deadly disease. God is rarely held accountable by believers for all of the deaths that occur when people are not saved by a "miracle." On the whole, the tiny percentage of "miraculous" recoveries would be greater evidence of a deity's arbitrary cruelty than his benevolence, but this is never something believers seem comfortable discussing.

People don’t line up in medical school to get intimate with AIDS, parasitic worms, and flesh-eating bacteria. The natural human impulse is to pull away and protect ourselves, and to think we’re safe because we’re not in some jungle, waiting for the next Ebola outbreak. But the truth is, in the big-city HMO where I work, I often get paged twenty or thirty times a day to size up infectious diseases that come from what we eat, what we breathe, what we touch, and where we go. The rare and mysterious cases I see walk into my hospital every day.

In one experiment, subjects who were asked to imagine having been exposed to a rare fatal disease—there was a 1 in 1,000 chance they had caught it—were willing to pay only $2,000 for the only available dose of the antidote.19 The same subjects said that, under identical conditions, they would have to be paid 250 times as much to induce them to voluntarily expose themselves to the disease if there was no available antidote. This asymmetry is striking, since in both cases, people would be buying a one-in-a-thousand reduction in their likelihood of death.

The percentage of civilized men who breathe correctly is quite small, and the result is shown in contracted chests and stooping shoulders, and the terrible increase in diseases of the respiratory organs, including that dread monster, Consumption, “the white scourge.” Eminent authorities have stated that one generation of correct breathers would regenerate the race, and disease would be so rare as to be looked upon as a curiosity. Whether looked at from the standpoint of the Oriental or Occidental, the connection between correct breathing and health is readily seen and explained.

It seems obvious that throughout history, as one of the few professions open to women, midwifery must have attracted women of unusual intelligence, competence, and self-respect§. While acknowledging that many remedies used by the witches were “purely magical” and worked, if at all, by suggestion, Ehrenreich and English point out an important distinction between the witch-healer and the medical man of the late Middle Ages: . . . the witch was an empiricist; She relied on her senses rather than on faith or doctrine, she believed in trial and error, cause and effect. Her attitude was not religiously passive, but actively inquiring. She trusted her ability to find ways to deal with disease, pregnancy and childbirth—whether through medication or charms. In short, her magic was the science of her time. By contrast: There was nothing in late mediaeval medical training that conflicted with church doctrine, and little that we would recognize as “science”. Medical students . . . spent years studying Plato, Aristotle and Christian theology. . . . While a student, a doctor rarely saw any patients at all, and no experimentation of any kind was taught. . . . Confronted with a sick person, the university-trained physician had little to go on but superstition. . . . Such was the state of medical “science” at the time when witch-healers were persecuted for being practitioners of “magic”.15 Since asepsis and the transmission of disease through bacteria and unwashed hands was utterly unknown until the latter part of the nineteenth century, dirt was a presence in any medical situation—real dirt, not the misogynistic dirt associated by males with the female body. The midwife, who attended only women in labor, carried fewer disease bacteria with her than the physician.

Originally, the word power meant able to be. In time, it was contracted to mean to be able. We suffer the difference. Iwas waiting for a plane when I overheard two businessmen. One was sharing the good news that he had been promoted, and the other, in congratulation, said, “More power to you.” I've heard this expression before, but for some reason, I heard it differently this time and thought, what a curious sentiment. As a good wish, the assumption is that power is the goal. Of course, it makes a huge difference if we are wishing others worldly power or inner power. By worldly power, I mean power over things, people, and situations—controlling power. By inner power, I mean power that comes from being a part of something larger—connective power. I can't be certain, but I'm fairly sure the wish here was for worldly power, for more control. This is commonplace and disturbing, as the wish for more always issues from a sense of lack. So the wish for more power really issues from a sense of powerlessness. It is painfully ironic that in the land of the free, we so often walk about with an unspoken and enervating lack of personal freedom. Yet the wish for more controlling power will not set us free, anymore than another drink will quench the emptiness of an alcoholic in the grip of his disease. It makes me think of a game we played when I was nine called King of the Hill, in which seven or eight of us found a mound of dirt, the higher the better, and the goal was to stand alone on top of the hill. Once there, everyone else tried to throw you off, installing themselves as King of the Hill. It strikes me now as a training ground for worldly power. Clearly, the worst position of all is being King of the Hill. You are completely alone and paranoid, never able to trust anyone, constantly forced to spin and guard every direction. The hills may change from a job to a woman to a prized piece of real estate, but those on top can be so enslaved by guarding their position that they rarely enjoy the view. I always hated King of the Hill—always felt tense in my gut when king, sad when not, and ostracized if I didn't want to play. That pattern has followed me through life. But now, as a tired adult, when I feel alone and powerless atop whatever small hill I've managed to climb, I secretly long for anyone to join me. Now, I'm ready to believe there's more power here together.

Parents: Do you have babies and toddlers who are afflicted by terminal illness, rare and incurable diseases? When all is not well for them, read to them this beautiful, enjoyable and lively healing book breathed by the Holy Spirit of a Sovereign God for your little ones' healing: Dear Baby Be Healed From Terminal Illness: Cutting Through soul and spirit by Stellah Mupanduki ...You will forget that there is illness in your household because you will encounter the healing presence of the Holy Spirit touching you and your little one with sound healing. Smile...cheer up, all will be well for you.

A true sense of community seems rare in our modern age. Even before the pandemic, many media reports were noting that we are experiencing a crisis of loneliness. Loneliness has been identified as a problem in numerous countries and across a range of demographics.11 This sense of disconnection wreaks havoc on the body. One study at Brigham Young University showed that feeling lonely has the same effect on longevity as smoking fifteen cigarettes a day.12 Poor social relationships have been associated with a 29 percent increase in the risk of heart disease and a 32 percent increase in risk of stroke.13

MOST legislators have been men of inferior capacity whom chance exalted over their fellows, and who took counsel almost exclusively of their own prejudices and whims. It would seem that they had not even a sense of the greatness and dignity of their work: they amused themselves by framing childish institutions, well devised indeed to please small minds, but discrediting their authors with people of sense. They flung themselves into useless details; and gave their attention to individual interests: the sign of the narrow genius, which grasps things piecemeal and cannot take a general view. Some of them have been so affected as to employ another language than the vernacular-a ridiculous thing in a framer of laws; for how can they be obeyed if they are not known? They have often abolished needlessly those which were already established-that is to say, they have plunged nations into the confusion which always accompanies change. It is true that, by reason of some extravagance springing rather from the nature than from the mind of man, it is sometimes necessary to change certain laws. But the case is rare; and when it happens it requires the most delicate handling; much solemnity ought to be observed, and endless precautions taken, in order to lead the people to the natural conclusion that the laws are most sacred, since so many formalities are necessary to their abrogation. Often they have made them too subtle, following logical instead of natural equity. As a consequence such laws have been found too severe; and a spirit of justice required that they should be set aside; but the cure was as bad as the disease. Whatever the laws may be, obedience to them is necessary; they are to be regarded as the public conscience, with which all private consciences ought to be in conformity. (Letter #79)

I’ve found that the most badass people I know, the ones who are the best in the world at their craft, are rarely busy in the way we’ve been taught to think of it. Being busy is a disease, a terminal one. It destroys your precious time. Being effective is about using every minute thoughtfully and mindfully as you make steady progress toward your dream. The biggest surprise to me has been that those people, those creators who are so deliberate and planned in the way they work, are also incredibly joyful and playful while they work. Planning and play aren’t opposites; they complement each other beautifully.

Abhed, my father had called heredity-"indivisible." There is an old trope in popular culture of the "crazy genius," a mind split between madness and brilliance, oscillating between the two states at the throw of a single switch. But Rajesh had no switch. There was no split or oscillation, no pendulum. The magic and the mania were perfectly contiguous-bordering kingdoms with no passports. They were part of the same whole, indivisible. "We of the craft are all crazy," Lord Byron, the high priest of crazies, wrote. "Some are affected by gaiety, others by melancholy, but all are more or less touched." Versions of this story have been tool, over and over, with bipolar disease, with some variants of schizophrenia, and with rare cases of autism; all are "more or less touched." It is tempting to romanticize psychotic illness, so let me emphasize that the men and women with these mental disorders experience paralyzing cognitive, social, and psychological disturbances that send gashes of devastation through their lives. But also indubitably, some patients with these syndromes possess exceptional and unusual abilities. The effervescence of bipolar disease has long been linked to extraordinary creativity; at times, the heightened creative impulse is manifest during the throes of mania.

I have heard people covering their sins by saying they are not religious, but I tell you this; it is better to love God Almighty and live a healed and protected long life that knows and honours God Almighty instead of groaning in pain and living hopelessly troubled lives because of incurable diseases. Be humble and open your heart to Jesus Christ and find mercy, stability, peace and salvation for you and your children. Do not live a lost life in this day and age where disasters, terminal, rare and chronic illnesses are devouring people's lives. Be wise and seek the Lord God Almighty for healing, cleansing and divine protection.Row your boat of life in Christ and move to the top

In my own periods of darkness, in the underworld of the soul, I find myself frequently overcome and amazed by the ability of people to befriend each other, to love their intimate partners and parents and children, and to do what they must do to keep the machinery of the world running. I knew a man, injured and disabled by a car accident, who was employed by a local utility. For years after the crash he worked side by side with another man, who for his part suffered with a degenerative neurological disease. They cooperated while repairing the lines, each making up for the other’s inadequacy. This sort of everyday heroism is the rule, I believe, rather than the exception. Most individuals are dealing with one or more serious health problems while going productively and uncomplainingly about their business. If anyone is fortunate enough to be in a rare period of grace and health, personally, then he or she typically has at least one close family member in crisis. Yet people prevail and continue to do difficult and effortful tasks to hold themselves and their families and society together. To me this is miraculous—so much so that a dumbfounded gratitude is the only appropriate response. There are so many ways that things can fall apart, or fail to work altogether, and it is always wounded people who are holding it together. They deserve some genuine and heartfelt admiration for that. It’s an ongoing miracle of fortitude and perseverance

If man is not ready to abdicate or to reconsider his case, it is because he has not yet drawn the final consequences of knowledge and of power. Convinced that his moment will come, that he will catch up with God and pass Him by, he clings—envious as he is—to the notion of evolution, as if the fact of advancing must necessarily bring him to the highest degree of perfection. Having sought to be other, he will end by being nothing; he is already nothing. Doubtless he is evolving, but against himself, to his cost, and toward a complexity which is ruining him. Becoming, progress: notions apparently tangential, actually divergent. True, everything changes, but rarely, if ever, for the better. Euphoric inflection of the original disease, of that false innocence which awakened in Adam a desire for the new, our faith in evolution, in the identity of becoming and progress, will collapse only when man, having reached the extremity of his distraction, having turned at last to the knowledge which leads to deliverance and not to power, will be in a position to offer an irrevocable no to his exploits and to his work. If he continues to clutch at them, he will doubtless enter upon the career of a ludicrous god or an obsolete animal, a solution as convenient as it is degrading, the ultimate stage of his infidelity to himself. Whatever choice he makes, and though he has not exhausted all the virtues of his failure, he has nonetheless fallen so low that it is hard to understand why he does not pray unceasingly, until his very voice and reason are extinguished.

Even years later traumatized people often have enormous difficulty telling other people what has happened to them. Their bodies reexperiences terror, rage, and helplessness, as well as the impulse to fight or flee, but these feelings are almost impossible to articulate. Trauma by nature drives us to the edge of comprehension, cutting us off from language based on common experience or an imaginable past... Sooner or later most survivors... come up with what many of them call their "cover story" that offers some explanation for their symptoms and behavior for public consumption. These stories, however, rarely capture the inner truth of the experience. It is enormously difficult to organize one's traumatic experiences into a coherent account - a narrative with a beginning, middle, and an end.

Fed by such events, the legend grew until there were anecdotes to give substance to nearly all of Stoner's more typical activities, and grew until it reached his life outside the University. It finally included even Edith, who was seen with him so rarely at University functions that she was a faintly mysterious figure who flitted across the collective imagination like a ghost: she drank secretly, out of some obscure and distant sorrow; she was dying slowly of a rare and always fatal disease; she was a brilliantly talented artist who had given up her career to devote herself to Stoner. At public functions her smile flashed out of her narrow face so quickly and nervously, her eyes glinted so brightly, and she spoke so shrilly and disconnectedly that everyone was sure that her appearance masked a reality, that a self hid behind the facade that no one could believe.

One thing about living in a psychological era is that few people give credence or value to a philosophical perspective. In our period, despairing of finding any meaning in life is rarely considered a sincerely held worldview; no, it is a sickness that needs to be cured. If I said to a psychiatrist that by treating existential ennui as a disease they are making the gratuitous assumption that the correct way to live is cheerfully and hopefully, they would look at me as if I was, well, sick in the head. Most shrinks presuppose that the goal of life is to become positive and to have a sense of well-being and that it is not healthy to feel or think otherwise. But what if, after philosophical contemplation, a person finds life empty? What if they cannot find any meaning in life, either rationally or in the depths of their being? Does that simply mean it’s Prozac time?

Canada is an Aboriginal country as well as a settler country. We rarely see ourselves that way, but it is past time that we started doing so. The fact that settlers are in a significant majority does not take away from the simple fact that when Europeans made first contact with the northern half of North America, there were millions of people already here. From the Beothuk in Newfoundland – a population completely wiped out by disease and violence – across every corner of Canada to the far west and north, Canada’s first people had built a civilization, a way of life thousands of years old and rich in diversity. They were not “savages” (as they were called, in French and English), nor were they “ignorant wretches”, nor were they less than people. They had developed complex societies with distinct languages, systems of governance; they were real people with a real way of life.

Chelsea was something else. Like an unstoppable force of nature. Similar to a hurricane or a tornado. Or a pit bull. Violet admired that about her. And, in this instance, Chelsea had proven to be nothing less than formidable. So when Jay had mentioned earlier in the week that they might be able to go to the movies over the weekend, Chelsea held him to it. A time and a place were chosen. And word spread. And, somehow, Chelsea managed to unravel it all. She still wanted the Saturday night plans; she just didn’t want the crowd that came with them. She’d decided it should be more of a “double date.” With Mike. Except Mike would never see it coming. By the time the bell rang at the end of lunch on Friday, everyone had agreed to meet up for the seven o’clock showing the next night. But when they split up to go to their classes, Chelsea set her own plan into motion. She began to separate the others from the pack and, one by one, they all fell. She started with Andrew Lauthner. Poor Andrew didn’t know what hit him. “Hey, Andy, did you hear?” From the look on his face, he didn’t hear anything other than that Chelsea-his Chelsea-was talking to him. Out of the blue. Violet needed to get to class, but she was dying to see what Chelsea had up her sleeve, so she stuck it out instead. “What?” His huge frozen grin looked like it had been plastered there and dried overnight. Chelsea’s expression was apologetic, something that may have actually been difficult for her to pull off. “The movie’s been canceled. Plans are off.” She stuck out her lower lip in a disappointed pout. “But I thought…” He seemed confused. So was Violet. “…didn’t we just make the plans at lunch?” he asked. “I know.” Chelsea managed to sound as surprised as he did. “But you know how Jay is, always talking out of his ass. He forgot to mention that he has to work tomorrow night and can’t make it.” She looked at Violet and said, again apologetically, “Sorry you had to hear that, Vi.” Violet just stood there gaping and thinking that she should deny what Chelsea was saying, but she wasn’t even sure where to start. She knew Jules would have done it. Where was Jules when she needed her? “What about everyone else?” Andrew asked, still clinging to hope. Chelsea shrugged and placed a sympathetic hand on Andrew’s arm. “Nope. No one else can make it either. Mike’s got family plans. Jules has a date. Claire has to study. And Violet here is grounded.” She draped an arm around Violet’s shoulder. “Right, Vi?” Violet was saved from having to answer, since Andrew didn’t seem to need one. Apparently, if Chelsea said it, it was the gospel truth. But the pathetic look on his face made Violet want to hug him right then and there. "Oh," he finally said. And then, "Well, maybe next time." "Yeah. Sure. Of course," Chelsea called over her shoulder, already dragging Violet away from the painful scene. "Geez, Chels, break his heart, why don't you? Why didn't you just say you have some rare disease or something?" Violet made a face at her friend. "Not cool." Chelsea scoffed. "He'll be fine. Besides, if I said 'disease,' he would have made me some chicken soup and offered to give me a sponge bath or something." She wrinkled her nose. "Eww." The rest of the afternoon went pretty much the same way, with a few escalations: Family obligations. Big tests to study for. House arrests. Chelsea made excuses to nearly everyone who'd planned on going, including Clair. She was relentless. By Saturday night, it was just the four of them...Violet, Jay, Chelsea, and, of course, Mike. It was everything Chelsea had dreamed of, everything she'd worked for.

Like it or not, we are slightly fat, furless, bipedal primates who crave sugar, salt, fat, and starch, but we are still adapted to eating a diverse diet of fibrous fruits and vegetables, nuts, seeds, tubers, and lean meat. We enjoy rest and relaxation, but our bodies are still those of endurance athletes evolved to walk many miles a day and often run, as well as dig, climb, and carry. We love many comforts, but we are not well adapted to spend our days indoors in chairs, wearing supportive shoes, staring at books or screens for hours on end. As a result, billions of people suffer from diseases of affluence, novelty, and disuse that used to be rare or unknown. We then treat the symptoms of these diseases because it is easier, more profitable, and more urgent than treating their causes, many of which we don’t understand anyway. In doing so, we perpetuate a pernicious feedback loop—dysevolution—between culture and biology. Maybe

Perfectionists are working not to improve the world but to keep it under control. They do everything perfectly not for the satisfaction of a job well done but as a way of camouflaging addiction’s presence in the family. By keeping everything orderly, they’re trying to make the disease less noticeable. They work tirelessly to create a perfect family life but are rarely cognizant of what motivates their obsession. Through their eyes, perfectionism is their finest quality. It’s the way they provide the ones they love with the very best. They have no idea that perfectionism is an outgrowth of fear and that it’s more about looking happy than being happy. The compulsion to have the cleanest house, cook the best meals, plant the perfect garden, and always look perfectly coiffed is, for the perfectionist, a way to stay safe. After all, when the house is well kept, the children are properly dressed, and everyone has good manners, how can

Dr. Kary Mullis, who won the Nobel Prize in Chemistry for inventing PCR, stated publicly numerous times that his invention should never be used for the diagnosis of infectious diseases. In July of 1997, during an event called Corporate Greed and AIDS in Santa Monica CA, Dr. Mullis explained on video, “With PCR you can find almost anything in anybody. It starts making you believe in the sort of Buddhist notion that everything is contained in everything else, right? I mean, because if you can model amplify one single molecule up to something that you can really measure, which PCR can do, then there’s just very few molecules that you don’t have at least one single one of them in your body. Okay? So that could be thought of as a misuse of it, just to claim that it’s meaningful.” Mikki explained, “The major issue with PCR is that it’s easily manipulated. It functions through a cyclical process whereby each revolution amplifies magnification. On a molecular level, most of us already have trace amounts of genetic fragments similar to coronavirus within us. By simply over-cycling the process, a negative result can be flipped to a positive. Governing bodies such as the CDC and the WHO can control the number of cases by simply advising the medical industry to increase or decrease the cycle threshold (CT).” In August of 2020, the New York Times reported that “a CT beyond 34 revolutions very rarely detect live virus, but most often, dead nucleotides that are not even contagious. In compliance with guidance from the CDC and the WHO, many top US labs have been conducting tests at cycle thresholds of 40 or more. NYT examined data from Massachusetts, New York, and Nevada and determined that up to 90 percent of the individuals who tested positive carried barely any virus.”17 90 percent! In May of 2021, CDC changed the PCR cycle threshold from 40 to 28 or lower for those who have been vaccinated. This one adjustment of the numbers allowed the vaccine pushers to praise the vaccines as a big success.

If disease could have done the job, it is not clear why the European colonizers in America found it necessary to carry out unrelenting wars against Indigenous communities in order to gain every inch of land they took from them—nearly three hundred years of colonial warfare, followed by continued wars waged by the independent republics of the hemisphere. Whatever disagreement may exist about the size of precolonial Indigenous populations, no one doubts that a rapid demographic decline occurred in the sixteenth and seventeenth centuries, its timing from region to region depending on when conquest and colonization began. Nearly all the population areas of the Americas were reduced by 90 percent following the onset of colonizing projects, decreasing the targeted Indigenous populations of the Americas from one hundred million to ten million. Commonly referred to as the most extreme demographic disaster—framed as natural—in human history, it was rarely called genocide until the rise of Indigenous movements in the mid-twentieth century forged questions.

The threat of difference has been no less blinding to people of Color. Those of us who are Black must see that the reality of our lives and our struggle does not make us immune to the errors of ignoring and misnaming difference. Within Black communities where racism is a living reality, differences among us often seem dangerous and suspect. The need for unity is often misnamed as a need for homogeneity, and a Black feminist vision mistaken for betrayal of our common interests as a people. Because of the continuous battle against racial erasure that Black women and Black men share, some Black women still refuse to recognize that we are also oppressed as women, and that sexual hostility against Black women is practiced not only by the white racist society, but implemented within our Black communities as well. It is a disease striking the heart of Black nationhood, and silence will not make it disappear. Exacerbated by racism and the pressures of powerlessness, violence against Black women and children often becomes a standard within our communities, one by which manliness can be measured. But these woman-hating acts are rarely discussed as crimes against Black women.

Hunter-gatherers who survive childhood typically live to be old: their most common age of death is between sixty-eight and seventy-two, and most become grandparents or even great-grandparents.70 They most likely die from gastrointestinal or respiratory infections, diseases such as malaria or tuberculosis, or from violence and accidents.71 Health surveys also indicate that most of the noninfectious diseases that kill or disable older people in developed nations are rare or unknown among middle-aged and elderly hunter-gatherers.72 These admittedly limited studies have found that hunter-gatherers rarely if ever get type 2 diabetes, coronary heart disease, hypertension, osteoporosis, breast cancer, asthma, and liver disease. They also don’t appear to suffer much from gout, myopia, cavities, hearing loss, collapsed arches, and other common ailments. To be sure, hunter-gatherers don’t live in perpetually perfect health, especially since tobacco and alcohol have become increasingly available to them, but the evidence suggests that they are healthy compared to many older Americans today despite never having received any medical care. In short, if you were to compare contemporary health data from people around the world with equivalent data from hunter-gatherers, you would not conclude that rising rates of common mismatch diseases such as heart disease and type 2 diabetes are straightforward, inevitable by-products of economic progress and increased longevity. Moreover,

Indian farmers grow maize in what is called a milpa. The term means “maize field,” but refers to something considerably more complex. A milpa is a field, usually but not always recently cleared, in which farmers plant a dozen crops at once, including maize, avocados, multiple varieties of squash and bean, melon, tomatoes, chilis, sweet potato, jicama (a tuber), amaranth (a grain-like plant), and mucuna (a tropical legume). In nature, wild beans and squash often grow in the same field as teosinte, the beans using the tall teosinte as a ladder to climb toward the sun; below ground, the beans’ nitrogen-fixing roots provide nutrients needed by teosinte. The milpa is an elaboration of this natural situation, unlike ordinary farms, which involve single-crop expanses of a sort rarely observed in unplowed landscapes. Milpa crops are nutritionally and environmentally complementary. Maize lacks digestible niacin, the amino acids lysine and tryptophan, necessary to make proteins and diets with too much maize can lead to protein deficiency and pellagra, a disease caused by lack of niacin. Beans have both lysine and tryptophan, but not the amino acids cysteine and methionine, which are provided by maize. As a result, beans and maize make a nutritionally complete meal. Squashes, for their part, provide an array of vitamins; avocados, fats. The milpa, in the estimation of H. Garrison Wilkes, a maize researcher at the University of Massachusetts in Boston, “is one of the most successful human inventions ever created.

A similar vicious circle perpetuated the racial hierarchy in modern America. From the sixteenth to the eighteenth century, the European conquerors imported millions of African slaves to work the mines and plantations of America. They chose to import slaves from Africa rather than from Europe or East Asia due to three circumstantial factors. Firstly, Africa was closer, so it was cheaper to import slaves from Senegal than from Vietnam. Secondly, in Africa there already existed a well-developed slave trade (exporting slaves mainly to the Middle East), whereas in Europe slavery was very rare. It was obviously far easier to buy slaves in an existing market than to create a new one from scratch. Thirdly, and most importantly, American plantations in places such as Virginia, Haiti and Brazil were plagued by malaria and yellow fever, which had originated in Africa. Africans had acquired over the generations a partial genetic immunity to these diseases, whereas Europeans were totally defenceless and died in droves. It was consequently wiser for a plantation owner to invest his money in an African slave than in a European slave or indentured labourer. Paradoxically, genetic superiority (in terms of immunity) translated into social inferiority: precisely because Africans were fitter in tropical climates than Europeans, they ended up as the slaves of European masters! Due to these circumstantial factors, the burgeoning new societies of America were to be divided into a ruling caste of white Europeans and a subjugated caste of black Africans.

When the pandemic started, most of the other medical practices in the Detroit area shut down, Dr. David Brownstein told me. “I had a meeting with my staff and my six partners. I told them, ‘We are going to stay open and treat COVID.’ They wanted to know how. I said, ‘We’ve been treating viral diseases here for twenty-five years. COVID can’t be any different.’ In all that time, our office had never lost a single patient to flu or flu-like illness. We treated people in their cars with oral vitamins A, C, and D, and iodine. We administered IV solution outside all winter with IV hydrogen peroxide and vitamin C. We’d have them put their butts out the car window and shot them up with intramuscular ozone. We nebulized them with hydrogen peroxide and Lugol’s iodine. We only rarely used ivermectin and hydroxychloroquine. We treated 715 patients and had ten hospitalizations and no deaths. Early treatment was the key. We weren’t allowed to talk about it. The whole medical establishment was trying to shut down early treatment and silence all the doctors who talked about successes. A whole generation of doctors just stopped practicing medicine. When we talked about it, the whole cartel came for us. I’ve been in litigation with the Medical Board for a year. When we posted videos from some of our recovered patients, they went viral. One of the videos had a million views. FTC filed a motion against us, and we had to take everything down.” In July 2020, Brownstein and his seven colleagues published a peer-reviewed article describing their stellar success with early treatment. FTC sent him a letter warning him to take it down. “No one wanted Americans to know that you didn’t have to die from COVID. It’s 100 percent treatable,” says Dr. Brownstein. “We proved it. No one had to die.

AIA is about this girl named Anna (who narrates the story) and her one-eyed mom, who is a professional gardener obsessed with tulips, and they have a normal lower-middle- class life in a little central California town until Anna gets this rare blood cancer. But it’s not a cancer book, because cancer books suck. Like, in cancer books, the cancer person starts a charity that raises money to fight cancer, right? And this commitment to charity reminds the cancer person of the essential goodness of humanity and makes him/her feel loved and encouraged because s/he will leave a cancer-curing legacy. But in AIA, Anna decides that being a person with cancer who starts a cancer charity is a bit narcissistic, so she starts a charity called The Anna Foundation for People with Cancer Who Want to Cure Cholera. Also, Anna is honest about all of it in a way no one else really is: Throughout the book, she refers to herself as the side effect, which is just totally correct. Cancer kids are essentially side effects of the relentless mutation that made the diversity of life on earth possible. So as the story goes on, she gets sicker, the treatments and disease racing to kill her, and her mom falls in love with this Dutch tulip trader Anna calls the Dutch Tulip Man. The Dutch Tulip Man has lots of money and very eccentric ideas about how to treat cancer, but Anna thinks this guy might be a con man and possibly not even Dutch, and then just as the possibly Dutch guy and her mom are about to get married and Anna is about to start this crazy new treatment regimen involving wheatgrass and low doses of arsenic, the book ends right in the middle of a I know it’s a very literary decision and everything and probably part of the reason I love the book so much, but there is something to recommend a story that ends.

The Man-Moth Man-Moth: Newspaper misprint for “mammoth.” Here, above, cracks in the buildings are filled with battered moonlight. The whole shadow of Man is only as big as his hat. It lies at his feet like a circle for a doll to stand on, and he makes an inverted pin, the point magnetized to the moon. He does not see the moon; he observes only her vast properties, feeling the queer light on his hands, neither warm nor cold, of a temperature impossible to record in thermometers. But when the Man-Moth pays his rare, although occasional, visits to the surface, the moon looks rather different to him. He emerges from an opening under the edge of one of the sidewalks and nervously begins to scale the faces of the buildings. He thinks the moon is a small hole at the top of the sky, proving the sky quite useless for protection. He trembles, but must investigate as high as he can climb. Up the façades, his shadow dragging like a photographer’s cloth behind him he climbs fearfully, thinking that this time he will manage to push his small head through that round clean opening and be forced through, as from a tube, in black scrolls on the light. (Man, standing below him, has no such illusions.) But what the Man-Moth fears most he must do, although he fails, of course, and falls back scared but quite unhurt. Then he returns to the pale subways of cement he calls his home. He flits, he flutters, and cannot get aboard the silent trains fast enough to suit him. The doors close swiftly. The Man-Moth always seats himself facing the wrong way and the train starts at once at its full, terrible speed, without a shift in gears or a gradation of any sort. He cannot tell the rate at which he travels backwards. Each night he must be carried through artificial tunnels and dream recurrent dreams. Just as the ties recur beneath his train, these underlie his rushing brain. He does not dare look out the window, for the third rail, the unbroken draught of poison, runs there beside him. He regards it as a disease he has inherited the susceptibility to. He has to keep his hands in his pockets, as others must wear mufflers. If you catch him, hold up a flashlight to his eye. It’s all dark pupil, an entire night itself, whose haired horizon tightens as he stares back, and closes up the eye. Then from the lids one tear, his only possession, like the bee’s sting, slips. Slyly he palms it, and if you’re not paying attention he’ll swallow it. However, if you watch, he’ll hand it over, cool as from underground springs and pure enough to drink.