Prefrontal Cortex Quotes

I did not know that my entire personality, my entire being, could be discarded as the byproduct of my anatomy. What if I really am just someone with a large prefrontal cortex...and nothing more?

The good part about having a mental disorder is having a valid reason for all the stupid things we do because of a damaged prefrontal cortex. However, the best part is seeing someone completely sane do the exact same things, without a valid excuse. This is the great equalizer of God and his little gift for all us crazy people to enjoy.

Meditation is blossoming of the prefrontal cortex to overcome the momentum of the nature. It is coming out of the loops of memories, patterns,fears, dreams and anger.

Mindfulness increases activation of the medial prefrontal cortex and decreases activation of structures like the amygdala that trigger our emotional responses. This increases our control over the emotional brain.

The warmth and satisfaction of positive contact with the adult is often just as good as a psychostimulant in supplying the child’s prefrontal cortex with dopamine.

The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school.

How do we regulate our emotions? The answer is surprisingly simple: by thinking about them. The prefrontal cortex allows each of us to contemplate his or her own mind, a talent psychologists call metacognition. We know when we are angry; every emotional state comes with self-awareness attached, so that an individual can try to figure out why he's feeling what he's feeling. If the particular feeling makes no sense—if the amygdala is simply responding to a loss frame, for example—then it can be discounted. The prefrontal cortex can deliberately choose to ignore the emotional brain.

Multitasking has been found to increase the production of the stress hormone cortisol as well as the fight-or-flight hormone adrenaline, which can overstimulate your brain and cause mental fog or scrambled thinking. Multitasking creates a dopamine-addiction feedback loop, effectively rewarding the brain for losing focus and for constantly searching for external stimulation. To make matters worse, the prefrontal cortex has a novelty bias, meaning that its attention can be easily hijacked by something new—the proverbial shiny objects

Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, the right area that plays a role in creative thought, emotions, formation of mental abstractions, and negative emotions.

Recent brain scans have shed light on how the brain simulates the future. These simulation are done mainly in the dorsolateral prefrontal cortex, the CEO of the brain, using memories of the past. On one hand, simulations of the future may produce outcomes that are desirable and pleasurable, in which case the pleasure centers of the brain light up (in the nucleus accumbens and the hypothalamus). On the other hand, these outcomes may also have a downside to them, so the orbitofrontal cortex kicks in to warn us of possible dancers. There is a struggle, then, between different parts of the brain concerning the future, which may have desirable and undesirable outcomes. Ultimately it is the dorsolateral prefrontal cortex that mediates between these and makes the final decisions. (Some neurologists have pointed out that this struggle resembles, in a crude way, the dynamics between Freud's ego, id, and superego.)

Indeed, brain scans done by scientists at Washington University in St. Louis indicate that areas used to recall memories are the same as those involved in simulating the future. In particular, the link between the dorsolateral prefrontal cortex and the hippocampus lights up when a person is engaged in planning for the future and remembering the past.

Meditate. Neuroscientists have found that monks who spend years meditating actually grow their left prefrontal cortex, the part of the brain most responsible for feeling happy. But don’t worry, you don’t have to spend years in sequestered, celibate silence to experience a boost. Take just five minutes each day to watch your breath go in and out.

The other way to train medics is to have them practice a skill so many times that it becomes automatic. So when the prefrontal cortex goes AWOL, when reasoning drops away, muscle memory, one hopes, will persist.

You can change dopamine and the dorsal striatum with exercise. You can boost serotonin with a massage. You can make decisions and set goals to activate the ventromedial prefrontal cortex. You can reduce amygdala activity with a hug and increase anterior cingulate activity with gratitude. You can enhance prefrontal norepinephrine with sleep.

The prefrontal cortex takes in some outside information. The amygdala says I REMEMBER THAT! LAST TIME THAT SHIT HAPPENED, IT HURT! HURT SUCKS! And the brainstem tells the prefrontal cortex GET THE FUCK UP OUT OF THERE! WE DON’T LIKE TO HURT!

The adolescent brain makes important new pathways and connections, but the cognitive functions of the prefrontal cortex, the seat of judgment, don’t mature until around age twenty-five. (The emotional control functions follow at around thirty-two!)

right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

The key arsenal of dark democracy is developing hatred and enmity towards the neighboring countries. Politicians do this just to block the prefrontal cortex or the wisdom brain of the mass and to activate the amygdala, the fear centers of the brain of the mass.

Non-Conformity The path of non-conformity never takes the shortest distance between two points. It's convoluted like our prefrontal cortex.

Bring your dopamine or adrenaline level down by activating other regions of the brain other than the prefrontal cortex.

Comparing the patterns of brain activity between the two conditions within the same individual, we discovered that supervisory regions in the prefrontal cortex required for thoughtful judgments and controlled decisions had been silenced in their activity by a lack of sleep.

War hysteria and dark nationalism deactivates the mass prefrontal cortex ( the rational brain ) and activates the amygdala ( the fear centers ). They are the key tools for dark democracy.

For many men, just seeing a woman in a sexually objectifying pose, such as in a bikini, deactivates the part of the brain's prefrontal cortex, the part of the brain where thinking about people and their intentions, feelings and actions happens. Instead, the region of the brain that lights up... is the one that reacts to looking at inanimate objects, such as a pen or a ball.

It was as if the amygdala was the accelerator of defensive reactions and the prefrontal cortex the brake upon them (Figure 11.1). Malfunction of the brake makes the expression of the reactions hard to control. This idea has since been supported by research in animals and humans and is now commonly accepted.10

Without sleep, however, the strong coupling between these two brain regions is lost. We cannot rein in our atavistic impulses—too much emotional gas pedal (amygdala) and not enough regulatory brake (prefrontal cortex).

There is overwhelming evidence that meditation can increase focus and decrease anxiety, depression, and cortisol flooding. There is evidence that it decreases activation in the amygdala, one epicenter of fear in the brain, and increases activity in the prefrontal cortex. People who meditate are able to unstick themselves from cyclical, dangerous thinking and see things from a calmer, more positive perspective. The sympathetic nervous system, or the fight or flight system, is activated by stress. This is the system that gets us ready to run. The counter to this is the parasympathetic nervous system, the resting and digesting system. It lowers heart rate and blood pressure, slows breathing, and directly counters the stress response. Meditation activates the parasympathetic nervous system. It’s literally the antidote to stress. Plus, it’s what all the evolved, cool girls who look good without makeup are doing, according to social media.

The warmth and satisfaction of positive contact with the adult is often just as good as a psychostimulant in supplying the child’s prefrontal cortex with dopamine. Greater security means less anxiety and more focused attention. The unseen factor that remains constant in all situations is the child’s unconscious yearning for attachment, dating back to the first years of life.

The neuroscientist Joseph LeDoux and his colleagues have shown that the only way we can consciously access the emotional brain is through self-awareness, i.e. by activating the medial prefrontal cortex, the part of the brain that notices what is going on inside us and thus allows us to feel what we’re feeling.5 (The technical term for this is “interoception”—Latin for “looking inside.”)

How poorly today’s North American way of life serves the needs of the human body may be gauged by the high levels of, say, heart disease, diabetes and obesity on this continent. The situation of the human brain is analogous. The miswired ADD circuits of the prefrontal cortex are as much the effect of unhealthful circumstances as are the cholesterol-plugged arteries of atherosclerotic coronary disease.

Brain scans prove that patients who’ve sustained significant childhood trauma have brains that look different from people who haven’t. Traumatized brains tend to have an enlarged amygdala—a part of the brain that is generally associated with producing feelings of fear. Which makes sense. But it goes further than that: For survivors of emotional abuse, the part of their brain that is associated with self-awareness and self-evaluation is shrunken and thin. Women who’ve suffered childhood sexual abuse have smaller somatosensory cortices—the part of the brain that registers sensation in our bodies. Victims who were screamed at might have an altered response to sound. Traumatized brains can result in reductions in the parts of the brain that process semantics, emotion and memory retrieval, perceiving emotions in others, and attention and speech. Not getting enough sleep at night potentially affects developing brains’ plasticity and attention and increases the risk of emotional problems later in life. And the scariest factoid, for me anyway: Child abuse is often associated with reduced thickness in the prefrontal cortex, the part of the brain associated with moderation, decision-making, complex thought, and logical reasoning. Brains do have workarounds. There are people without amygdalae who don’t feel fear. There are people who have reduced prefrontal cortices who are very logical. And other parts of the brain can compensate, make up the lost parts in other ways. But overall, when I looked at the breadth of evidence, the results felt crushing. The fact that the brain’s cortical thickness is directly related to IQ was particularly threatening to me. Even if I wasn’t cool, or kind, or personable, I enjoyed the narrative that I was at least effective. Intelligent. What these papers seemed to tell me is that however smart I am, I’m not as smart as I could have been had this not happened to me. The questions arose again: Is this why my pitches didn’t go through? Is this why my boss never respected me? Is this why I was pushed to do grunt work in the back room?

In brain scans, music lights up the medial prefrontal cortex and triggers a memory that starts playing in your mind. All of a sudden you can see a place, a person, an incident. The strongest responses to music—the ones that elicit vivid memories—cause the greatest activity on brain scans.

Scientists have learned that animals that experience prolonged stress have less activity in the parts of their brain that handle higher-order tasks—for example, the prefrontal cortex—and more activity in the primitive parts of their brain that are focused on survival, such as the amygdala.

There will come a time when a person you most likely pushed out through your vagina and nursed from your nipples, whose bottom you wiped, and whose snot and spit you cleaned up over several sleep-starved years will apprehend you with a mixture of boredom and irritation and say, ‘Get a life, Mum.’ This would be a good time to remember that a) violence never solved anything; b) teenagers don’t have a full brain yet – the prefrontal cortex that controls the ability to make important distinctions, like who controls the pocket money, only kicks in around the age of twenty-four; and c) you are, in fact, the adult.

Here’s how to get started: 1. Sit still and stay put . Sit in a chair with your feet flat on the ground, or sit cross-legged on a cushion. Sit up straight and rest your hands in your lap. It’s important not to fidget when you meditate—that’s the physical foundation of self-control. If you notice the instinct to scratch an itch, adjust your arms, or cross and uncross your legs, see if you can feel the urge but not follow it. This simple act of staying still is part of what makes meditation willpower training effective. You’re learning not to automatically follow every single impulse that your brain and body produce. 2. Turn your attention to the breath. Close your eyes or, if you are worried about falling asleep, focus your gaze at a single spot (like a blank wall, not the Home Shopping Network). Begin to notice your breathing. Silently say in your mind “inhale” as you breathe in and “exhale” as you breathe out. When you notice your mind wandering (and it will), just bring it back to the breath. This practice of coming back to the breath, again and again, kicks the prefrontal cortex into high gear and quiets the stress and craving centers of your brain . 3. Notice how it feels to breathe, and notice how the mind wanders. After a few minutes, drop the labels “inhale/exhale.” Try focusing on just the feeling of breathing. You might notice the sensations of the breath flowing in and out of your nose and mouth. You might sense the belly or chest expanding as you breathe in, and deflating as you breathe out. Your mind might wander a bit more without the labeling. Just as before, when you notice yourself thinking about something else, bring your attention back to the breath. If you need help refocusing, bring yourself back to the breath by saying “inhale” and “exhale” for a few rounds. This part of the practice trains self-awareness along with self-control. Start with five minutes a day. When this becomes a habit, try ten to fifteen minutes a day. If that starts to feel like a burden, bring it back down to five. A short practice that you do every day is better than a long practice you keep putting off to tomorrow. It may help you to pick a specific time that you will meditate every day, like right before your morning shower. If this is impossible, staying flexible will help you fit it in when you can.

(When we force a smile, we activate facial muscles with our prefrontal cortex. But when we smile because we are in a good mood, our nerves are controlled by our limbic system, which activates a slightly different set of muscles. Our brains can tell the subtle difference between the two, which was beneficial for our evolution.)

The right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

Given that the pre-frontal cortex is a key to our success as a species, consuming any amount of alcohol or other intoxicant seems really stupid.

Our problem-scanning machine (amygdala) and our serenity-now mood tape (prefrontal cortex) are at war.

With the prefrontal cortex down-regulated, most impulse control mechanisms go offline too. For people who aren't used to this combination, the results can be expensive.

Certainly the prefrontal cortex is an important thing; I’m as proud of mine as the next guy.

Interestingly, pathological liars have atypically large amounts of white matter in the prefrontal cortex, indicating more complex wiring.

The functioning of the prefrontal cortex is inhibited by alcohol, which can lead to sudden, mindless violence after a night out.

When my father was a soldier, his prefrontal cortex wasn’t yet complete. He could not grow a full mustache, and when he came back home he had a cane and a DIY tattoo of a woman’s name.

People who are very Tuned In to context tend to have strong connections from the hippocampus to areas in the prefrontal cortex that control executive functions and that hold long-term memories in the neocortex.

they arouse the inhibitory function. They wake up the cop, alert the underdeveloped and underactive circuitry of the prefrontal cortex. Recognizing that ADD is a problem of development rather than one of pathology

In fact, a recent fMRI study shows that when people use self-talk to reassess upsetting situations, activity in their prefrontal cortex increases in an amount correlated with a decrease of activity in their amygdala.

WILLPOWER EXPERIMENT: BREATHE YOUR WAY TO SELF-CONTROL You won’t find many quick fixes in this book, but there is one way to immediately boost willpower: Slow your breathing down to four to six breaths per minute. That’s ten to fifteen seconds per breath—slower than you normally breathe, but not difficult with a little bit of practice and patience. Slowing the breath down activates the prefrontal cortex and increases heart rate variability, which helps shift the brain and body from a state of stress to self-control mode. A few minutes of this technique will make you feel calm, in control, and capable of handling cravings or challenges.4 It’s

Stanford psychologist Laura Carstensen, to name one such example, used an fMRI scanner to study the brain behavior of subjects presented with both positive and negative imagery. She found that for young people, their amygdala (a center of emotion) fired with activity at both types of imagery. When she instead scanned the elderly, the amygdala fired only for the positive images. Carstensen hypothesizes that the elderly subjects had trained the prefrontal cortex to inhibit the amygdala in the presence of negative stimuli. These elderly subjects were not happier because their life circumstances were better than those of the young subjects; they were instead happier because they had rewired their brains to ignore the negative and savor the positive. By skillfully managing their attention, they improved their world without changing anything concrete about it.

(The production of myelin by OPCs in the brains of infants and children helps explain how they do smart things; the incomplete myelination of the prefrontal cortex in the brains of teens helps explain why they do stupid things.)

Since then neuroscience research has shown that we possess two distinct forms of self-awareness: one that keeps track of the self across time and one that registers the self in the present moment. The first, our autobiographical self, creates connections among experiences and assembles them into a coherent story. This system is rooted in language. Our narratives change with the telling, as our perspective changes and as we incorporate new input. The other system, moment-to-moment self-awareness, is based primarily in physical sensations, but if we feel safe and are not rushed, we can find words to communicate that experience as well. These two ways of knowing are localized in different parts of the brain that are largely disconnected from each other.10 Only the system devoted to self-awareness, which is based in the medial prefrontal cortex, can change the emotional brain. In the groups I used to lead for veterans, I could sometimes see these two systems working side by side. The soldiers told horrible tales of death and destruction, but I noticed that their bodies often simultaneously radiated a sense of pride and belonging.

Throughout the human life span there remains a constant two-way interaction between psychological states and the neurochemistry of the frontal lobes, a fact that many doctors do not pay enough attention to. One result is the overreliance on medications in the treatment of mental disorders. Modern psychiatry is doing too much listening to Prozac and not enough listening to human beings; people’s life histories should be given at least as much importance as the chemistry of their brains. The dominant tendency is to explain mental conditions by deficiencies of the brain’s chemical messengers, the neurotransmitters. As Daniel J. Siegel has sharply remarked, “We hear it said everywhere these days that the experience of human beings comes from their chemicals.” Depression, according to the simple biochemical model, is due to a lack of serotonin — and, it is said, so is excessive aggression. The answer is Prozac, which increases serotonin levels in the brain. Attention deficit is thought to be due in part to an undersupply of dopamine, one of the brain’s most important neurotransmitters, crucial to attention and to experiencing reward states. The answer is Ritalin. Just as Prozac elevates serotonin levels, Ritalin or other psychostimulants are thought to increase the availability of dopamine in the brain’s prefrontal areas. This is believed to increase motivation and attention by improving the functioning of areas in the prefrontal cortex. Although they carry some truth, such biochemical explanations of complex mental states are dangerous oversimplifications — as the neurologist Antonio Damasio cautions: "When it comes to explaining behavior and mind, it is not enough to mention neurochemistry... The problem is that it is not the absence or low amount of serotonin per se that “causes” certain manifestations. Serotonin is part of an exceedingly complicated mechanism which operates at the level of molecules, synapses, local circuits, and systems, and in which sociocultural factors, past and present, also intervene powerfully. The deficiencies and imbalances of brain chemicals are as much effect as cause. They are greatly influenced by emotional experiences. Some experiences deplete the supply of neurotransmitters; other experiences enhance them. In turn, the availability — or lack of availability — of brain chemicals can promote certain behaviors and emotional responses and inhibit others. Once more we see that the relationship between behavior and biology is not a one-way street.

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

By physically moving instead of stopping to think, the physiology changes and the mind follows suit. It activates the prefrontal cortex or the part of the brain that enables a person to focus so that he/she can change or take deliberate actions.

Mischel’s next step made his studies iconic — he tracked the kids forward, seeing if marshmallow wait time predicted anything about their adulthoods . [...] Five-year-old champs at marshmallow patience averaged higher SAT scores in high school (compared with those who couldn’t wait). [...] Forty years post-marshmallow, they excelled at frontal function, had more PFC [Prefrontal cortex] activation during a frontal task, and had lower BMIs. A gazillion-dollar brain scanner doesn’t hold more predictive power than one marshmallow.

Robert Sapolsky, a neurobiologist at Stanford University, has argued that the main job of the modern prefrontal cortex is to bias the brain—and therefore, you—toward doing “the harder thing.” When it’s easier to stay on the couch, your prefrontal cortex makes you want to get up and exercise. When it’s easier to say yes to dessert, your prefrontal cortex remembers the reasons for ordering tea instead. And when it’s easier to put that project off until tomorrow, it’s your prefrontal cortex that helps you open the file and make progress anyway.

the parts of the brain corresponding to the limbic system (thought to respond only to more visceral, immediate rewards) were activated only when the decision involved comparing a reward today with one in the future. In contrast, the lateral prefrontal cortex (a more “calculating” part of the brain) responded with a similar intensity to all decisions, regardless of the timing of the options. Brains that work like this would produce a lot of failed good intentions. And indeed, we do see a lot of those, from New Year’s resolutions to gym memberships that lie unused.

Kris was in black running shorts and a tight gray T-shirt constructed from some sort of magical material that clung to his muscles and triggered a gush of epinephrine while her amygdala attempted to reconcile two conflicting signals from her prefrontal cortex: attraction and revenge. “All

Classifying depression as an illness serves the psychiatric community and pharmaceutical corporations well; it also soothes the frightened, guilty, indifferent, busy, sadistic, and unschooled. To understand depression as a call for life-changes is not profitable. Stagnation is not a medical term. The 17.5 million Americans diagnosed as suffering a major depression in 1997 were mostly damned. (Psychobiological examinations confuse cause and symptom.) Deficient serotonergic functioning, ventral prefrontal cerebral cortex, dis-inhibition of impulsive-aggressive behavior, blah blah blah: the medical lexicon boils emotion from human being. Go take a drug, the doctor says. Pain is a biochemical phenomenon. Erase all memory.

Stay in the now. Pay attention to the things that are happening now, and don’t pay attention to the things that aren’t happening now. Focusing on the present helps reduce anxiety and worry, because it decreases emotional, self-focused processing in the ventromedial prefrontal cortex. Attention to the present also increases dorsolateral and ventrolateral prefrontal activity, allowing these regions to calm the amygdala.15 Improving your ability to stay present, a practice known as “mindfulness,” helps enhance these activations and leads to long-term improvements in anxiety and worrying.

efficiently means providing slots in our schedules where we can maintain an attentional set for an extended period. This allows us to get more done and finish up with more energy. Related to the manager/worker distinction is that the prefrontal cortex contains circuits responsible for telling us whether we’re controlling something or someone else is. When we set up a system, this part of the brain marks it as self-generated. When we step into someone else’s system, the brain marks it that way. This may help explain why it’s easier to stick with an exercise program or diet that someone else sets up: We typically trust them as “experts” more than we trust ourselves. “My trainer told me to do three sets of ten reps at forty pounds—he’s a trainer, he must know what he’s talking about. I can’t design my own workout—what do I know?” It takes Herculean amounts of discipline to overcome the brain’s bias against self-generated motivational systems. Why? Because as with the fundamental attribution error we saw in Chapter 4, we don’t have access to others’ minds, only our own. We are painfully aware of all the fretting and indecision, all the nuances of our internal decision-making process that led us to reach a particular conclusion. (I really need to get serious about exercise.) We don’t have access to that (largely internal) process in others, so we tend to take their certainty as more compelling, in many cases, than our own. (Here’s your program. Do it every day.)

Attentional amplification of sensory awareness in any sensory medium is achieved by top-down signals from prefrontal cortex that modulate activity of single neurons in sensory brain areas in the absence of any sensory stimulation and significantly increase baseline activity in the corresponding target region.

dopamine is used to measure the addictive potential of any behavior or drug. The more dopamine a drug releases in the brain’s reward pathway (a brain circuit that links the ventral tegmental area, the nucleus accumbens, and the prefrontal cortex), and the faster it releases dopamine, the more addictive the drug.

Suppose you unexpectedly see a person you care about. Suddenly you feel the love you have, for that person. Let's follow the flow of information from the visual system through the brain to the point of the experience of love as best we can. First of all, the stimulus will flow from the visual system to the prefrontal cortex (putting an image of the loved one in working memory). The stimulus also reaches the explicit memory system of the temporal lobe and activates memories and integrates them with the image of the person. Simultaneously with these processes, the subcortical areas presumed to be involved in attachment will be activated (the exact paths by which the stimulus reaches these areas is not known, however). Activation of attachment circuits then impacts on working memory in several ways. One involves direct connections from the attachment areas to the prefrontal cortex (as with fear, it is the medial prefrontal region that is connected with subcortical attachment areas). Activation of attachment circuits also leads to activation of brain stem arousal networks, which then participate in the focusing of attention on the loved one by working memory. Bodily responses will also be initiated as outputs of attachment circuits, and contrast with the alarm responses initiated by fear and stress circuits. We approach rather than try to escape from or avoid the person, and these behavioral differences are accompanied by different physiological conditions within the body. This pattern of inputs to working memory from within the brain and from the body biases us more toward an open and accepting mode of processing than toward tension and vigilance. The net result in working memory is the feeling of love.

So you don’t have an inner lizard or an emotional beast-brain. There is no such thing as a limbic system dedicated to emotions. And your misnamed neocortex is not a new part; many other vertebrates grow the same neurons that, in some animals, organize into a cerebral cortex if key stages run for long enough. Anything you read or hear that proclaims the human neocortex, cerebral cortex, or prefrontal cortex to be the root of rationality, or says that the frontal lobe regulates so-called emotional brain areas to keep irrational behavior in check, is simply outdated or woefully incomplete. The triune brain idea and its epic battle between emotion, instinct, and rationality is a modern myth.

Neuroscientists have determined the brain’s dorsolateral prefrontal cortex is associated with decision making and cost-benefit assessments. If MRI brain scans had been performed on my friends and me one summer’s night when we were fifteen, they would have revealed a dark spot indicating a complete absence of activity in this region of our brains.

Fortunately, suppressing an impulse doesn’t always have to decrease your dopamine—it can actually feel good. The key is the prefrontal cortex, which is responsible for pursuing long-term goals and has the ability to modulate dopamine release in the nucleus accumbens. So suppressing an impulse can be rewarding, as long as it’s in service of your larger values.

Each of us—whether a loved daughter or not—has experienced hurts, slights, and disappointments that, even if half-forgotten or mostly unseen, remain remembered and a part of us nonetheless. Sometimes they are rooted in the deep past but, equally, they may be part of the lived present, and there may be moments when our own unresolved feelings may endanger the equilibrium of our relationships with our daughters. From the point of view of brain science, whether we address those feelings from what Siegel and Hartzell call the “high road”—the powers of reflection embedded in the prefrontal cortex of the brain—or the “low road”—automatic responses embedded in the past applied to the situation at hand—will make all the difference.

So you aren’t still in love with her?” I ask, eyebrows up, curious. “You’re over it? Over her? Sayonara, Daisy—” “Well—” His brows bend in the middle. BJ gives me a gentle but firm smile. “Magnolia.” “Oh—” I look at my fiancé. “Too much?” He gives me a tight smile. “You could try not talking for twenty seconds. See what happens.” I don’t do that. Instead I give Tiller an apologetic smile. “See, I was recently diagnosed with ADHD—” “Oh.” Tiller nods, not knowing what to say. “It impairs my prefrontal cortex—something about a neurotransmitter in the brain and then also lower levels of dopamine—which is so rude—don’t you think that’s so rude? Dopamine’s pretty nice—my doctor said it’s probably why I love shopping so much. And sex—

You never want one thing at any given moment of life. Your mind always comes up with at least two choices. If your limbic system wins, the choice you make seems to be pleasurable at first but in the long run ends up being the wrong one. And if your prefrontal cortex wins the choice you make may appear rough at first, but in the long run it turns out to be the right one.

Notice what you notice. You can’t control the random bits of information that pop into your head. But you can start to notice your biases. When you get annoyed that you’re stuck at a red light think, Oh, that’s interesting. I noticed this red light, but I didn’t notice the last green light I made. In short, try practicing nonjudgmental awareness. Nonjudgmental awareness is a form of mindfulness that simply means noticing without reacting emotionally, even when things don’t turn out as you expected. Awareness does not require emotion, because emotion and awareness are mediated by different brain regions. Noticing a mistake might automatically trigger the emotional amygdala, but becoming aware of your own reaction activates the prefrontal cortex, which calms the amygdala.

Some people have more highly activated left prefrontal cortexes and some people have more highly activated right prefrontal cortexes. (This has nothing to do with the question of hemispheric dominance that determines whether you are right-handed or left-handed, which occurs in other areas of the brain.) The majority of people have higher left-side activation. People with higher right-side activation tend to experience more negative emotion than people with higher left-side activation. Right-side activation also predicts how easily someone’s immune system will become depressed. The right-brain activation is also correlated with high baseline levels of cortisol, the stress hormone. Though the settled patterns of activation do not stabilize until adulthood, babies with greater right-side activation will become frantic when their mothers leave a room; babies with strong left-side activation will be more likely to explore the room without apparent distress. In babies, however, the balance is subject to change. “The likelihood,” Davidson says, “is that there’s more plasticity in the system in the early years of life, more opportunity for the environment to sculpt this circuitry.

The amygdala plays an important role in the acquisition, storage, expression, and extinction of threat memories. The ventromedial prefrontal cortex (PFCVM) regulates the acquisition, storage, expression, and extinction of threat memories by the amygdala. The hippocampus learns about the context of acquisition and modulates the expression and extinction of threat memories in relation to context.

Brain scans prove that patients who’ve sustained significant childhood trauma have brains that look different from those of people who haven’t.[8] Traumatized brains tend to have an enlarged amygdala—a part of the brain that is generally associated with producing feelings of fear. Which makes sense. But it goes further than that: For survivors of emotional abuse, the part of their brain that is associated with self-awareness and self-evaluation is shrunken and thin. Women who’ve suffered childhood sexual abuse have smaller somatosensory cortices—the part of the brain that registers sensation in our bodies. Victims who were screamed at might have an altered response to sound. Trauma can result in reductions in the parts of the brain that process semantics, emotion and memory retrieval, perceiving emotions in others, and attention and speech. Not getting enough sleep at night potentially affects developing brains’ plasticity and attention and increases the risk of emotional problems later in life. And the scariest factoid, for me anyway: Child abuse is often associated with reduced thickness in the prefrontal cortex, the part of the brain associated with moderation, decision-making, complex thought, and logical reasoning.

In neurochemical terms, when he feels threatened or thwarted, Trump moves into a fight-or-flight state. His amygdala is triggered, his hypothalamic-pituitary-adrenal axis activates, and his prefrontal cortex—the part of the brain that makes us capable of rationality and reflection—shuts down. He reacts rather than reflects, and damn the consequences. This is what makes his access to the nuclear codes so dangerous and frightening.

Soft power. When you need to speak up, be artful. Take care of your partner as best you can by explicitly cherishing them and your relationship. Start by letting them know you need repair, is this a good time? If your partner agrees to talk, thank them, start off with an appreciation - something you are thankful for that your partner has said or done, even if it's just that you appreciate their willingness to sit down and talk. Then state your intentions - a good thing to do generally: "I want to clear the air between us so that I can feel closer to you." Center yourself in your Wise Adult, prefrontal cortex, and remember love. Recall that the person you're addressing is someone you love, or at least care for, and in any case, you will have to live with them. Remembering love is a recentering practice. You're speaking to someone you care about in the hopes of making things better.

If you are one of those people who can’t hold a lot in mind at once—you lose focus and start daydreaming in lectures, and have to get to someplace quiet to focus so you can use your working memory to its maximum—well, welcome to the clan of the creative. Having a somewhat smaller working memory means you can more easily generalize your learning into new, more creative combinations. Because you’re learning new, more creative combinations. Having a somewhat smaller working memory, which grows from the focusing abilities of the prefrontal cortex, doesn’t lock everything up so tightly, you can more easily get input from other parts of your brain. These other areas, which include the sensory cortex, not only are more in tune with what’s going on in the environment, but also are the source of dreams, not to mention creative ideas. You may have to work harder sometimes (or even much of the time) to understand what’s going on, but once you’ve got something chunked, you can take that chunk and turn it outside in and inside round—putting it through creative paces even you didn’t think you were capable of! Here’s another point to put into your mental chunker: Chess, that bastion of intellectuals, has some elite players with roughly average IQs. These seemingly middling intellects are able to do better than some more intelligent players because they practice more. That’s the key idea. Every chess player, whether average or elite, grows talent by practicing. It is the practice—particularly deliberate practice on the toughest aspects of the material—that can help lift average brains into the realm of those with more “natural” gifts. Just as you can practice lifting weights and get bigger muscles over time, you can also practice certain mental patterns that deepen and enlarge in your mind.

So for James, too, will derives not from the freedom to initiate thoughts, but to focus on and select some while stifling, blocking-or vetoing-others. For Buddhist mindfulness practice, it is the moment of restraint that allows mindful awareness to take hold and deepen. The essence of directed mental force is first to stop the grinding machine-like automaticity of the urge to act. Only then can the wisdom of the prefrontal cortex be actively engaged.

Collectively this work suggests that the prefrontal cortex and the amygdala are reciprocally related. That is, in order for the amygdala to respond to fear reactions, the prefrontal region has to be shut down. By the same logic, when the prefrontal region is active, the amygdala would be inhibited, making it harder to express fear. Pathological fear, then, may occur when the amygdala is unchecked by the prefrontal cortex, and treatment of pathological fear may require that the patient learn to increase activity in the prefrontal region so that the amygdala is less free to express fear. Clearly, decision-making ability in emotional situations is impaired in humans with damage to the medial and ventral prefrontal cortex, and abnormalities there also may predispose people to develop fear and anxiety disorders. These abnormalities could be due to genetic or epigenetic organization of prefrontal synapses or to experiences that subtly alter prefrontal synaptic connections. Indeed, the behavior of animals with abmormalities of the medial prefrontal cortex is reminiscent of humans with anxiety disorders: they develop fear reactions that are difficult to regulate. Although objective information about the world may indicate that a situation is not dangerous, because they cannot properly regulate fear circuits, they experience fear and anxiety in these safe situations.

Anything perceived as a threat trips the amygdala—the brain’s hand-wringing sentry—to set in motion the biochemical cascade known as the fight-or-flight response. Bruce Siddle, who consults in this area and sits on the board of Strategic Operations, prefers the term “survival stress response.” Whatever you wish to call it, here is a nice, concise summary, courtesy of Siddle: “You become fast, strong, and dumb.” Our hardwired survival strategy evolved back when threats took the form of man-eating mammals, when hurling a rock superhumanly hard or climbing a tree superhumanly fast gave you the edge that might keep you alive. A burst of adrenaline prompts a cortisol dump to the bloodstream. The cortisol sends the lungs into overdrive to bring in more oxygen, and the heart rate doubles or triples to deliver it more swiftly. Meanwhile the liver spews glucose, more fuel for the feats at hand. To get the goods where the body assumes they’re needed, blood vessels in the large muscles of the arms and legs dilate, while vessels serving lower-priority organs (the gut, for example, and the skin) constrict. The prefrontal cortex, a major blood guzzler, also gets rationed. Good-bye, reasoning and analysis. See you later, fine motor skills. None of that mattered much to early man. You don’t need to weigh your options in the face of a snarling predator, and you don’t have time.

But young children, whose prefrontal cortexes have barely begun to ripen, can’t conceive of a future, which means they spend their lives in the permanent present, a forever feeling of right now. At times, this is a desirable state of consciousness; indeed, for meditators, it’s the ultimate aspiration. But living in the permanent present is not a practical parenting strategy. “Everybody would like to be in the present,” says Daniel Gilbert, a social psychologist at Harvard and author of the 2006 best-seller Stumbling on Happiness. “Certainly it’s true that there is an important role for being present in our lives. All the data say that. My own research says that.” The difference is that children, by definition, only live in the present, which means that you, as a parent, don’t get much of a chance. “Everyone is moving at the same speed toward the future,” he says. “But your children are moving at that same speed with their eyes closed. So you’re the ones who’ve got to steer.” He thinks about this for a moment. “You know, back in the early seventies, I hung out with a lot of people who wanted to live in the present. And it meant that no one paid the rent.” In effect, parents and small children have two completely different temporal outlooks. Parents can project into the future; their young children, anchored in the present, have a much harder time of it. This difference can be a formula for heartbreak for a small child.

Each time we check a Twitter feed or Facebook update, we encounter something novel and feel more connected socially (in a kind of weird impersonal cyber way) and get another dollop of reward hormones. But remember, it is the dumb, novelty-seeking portion of the brain driving the limbic system that induces this feeling of pleasure, not the planning, scheduling, higher-level thought centers in the prefrontal cortex. Make no mistake: E-mail, Facebook, and Twitter checking constitute a neural addiction

evidence from functional magnetic resonance imaging showing that patients with BPD have hyperactivity in the limbic areas of the brain, especially the amygdala, and hypoactivity in the prefrontal cortex [and] in complex interaction with childhood trauma common among borderline patients, can result in the . . . behavior recognized as the symptoms of BPD: impulsive aggression, lack of affective control, and a profound mistrust born out of early disruption in the development of emotional attachment.8 Obviously, psychological theories for BPD

Setting Goals to Increase Dopamine. People are often at their best when working toward a long-term, meaningful goal that they believe is achievable, like earning a degree or getting a promotion. That’s because not only is dopamine released when you finally achieve a long-term goal but it’s also released with each step you make as you move closer to achieving it. Having a goal also allows the prefrontal cortex to more effectively organize your actions. And most importantly, achieving the goal is often less important to happiness than setting the goal in the first place.

But Berns’s study also shed light on exactly why we’re such conformists. When the volunteers played alone, the brain scans showed activity in a network of brain regions including the occipital cortex and parietal cortex, which are associated with visual and spatial perception, and in the frontal cortex, which is associated with conscious decision-making. But when they went along with their group’s wrong answer, their brain activity revealed something very different. Remember, what Asch wanted to know was whether people conformed despite knowing that the group was wrong, or whether their perceptions had been altered by the group. If the former was true, Berns and his team reasoned, then they should see more brain activity in the decision-making prefrontal cortex. That is, the brain scans would pick up the volunteers deciding consciously to abandon their own beliefs to fit in with the group. But if the brain scans showed heightened activity in regions associated with visual and spatial perception, this would suggest that the group had somehow managed to change the individual’s perceptions. That was exactly what happened—the conformists showed less brain activity in the frontal, decision-making regions and more in the areas of the brain associated with perception. Peer pressure, in other words, is not only unpleasant, but can actually change your view of a problem.

If [t]he mind is a system with many parts, then an innate desire is just one component among others. Some faculties may endow us with greed or lust or malice, but others may endow us with sympathy, foresight, selfrespect, a desire for respect from others, and an ability to learn from our own experiences and those of our neighbors. These are physical circuits residing in the prefrontal cortex and other parts of the brain, not occult powers of a poltergeist, and they have a genetic basis and an evolutionary history no less than the primal urges. It is only the Blank Slate and the Ghost in the Machine that make people think that drives are “biological” but that thinking and decision making are something else.

The prefrontal cortex is a convergence zone. It receives connections from various specialized systems (like the visual and auditory sensory systems), enabling it to be aware of what's going on in the outside world and to integrate the information it gathers. It also receives connections from the hippocampus and other cortical areas involved in long-term explicit memory, allowing it to retrieve stored information (facts, personal experiences, schemata) relevant to the task at hand. In addition, it sends connections to areas involved in movement control (including movement-control areas in the frontal cortex as well as in subcortical regions), allowing executive decisions to be turned into voluntary actions.

Stress physiologists have found a biological explanation for this phenomenon as well. The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school. When you’re overwhelmed by uncontrollable impulses and distracted by negative feelings, it’s hard to learn the alphabet. And in fact, when kindergarten teachers are surveyed about their students, they say that the biggest problem they face is not children who don’t know their letters and numbers; it is kids who don’t know how to manage their tempers or calm themselves down after a provocation.

I think of sensitivity within ADHD as having two parts. First, there is a deep curiosity about and sensitivity to new information and stimuli, an experience not too different from that of a bee driven to discover all available pollen. Second, there is the sensitivity that results from being ADHD, especially if it’s been unknown, where people become sensitive to criticism and being judged. It’s hard to do well at some times and then at other times feel like a total failure—for being late, missing an appointment, missing a deadline, getting dates or times confused, or other results of having a challenged prefrontal cortex and struggling executive functioning. There is also a sensitivity to ourselves—our own emotions, regulating those emotions, and not being so hard on ourselves. It’s no surprise, then, that it is not uncommon for adults with ADHD to have meltdowns or “blowups”—like an adult tantrum.

What’s more, AI researchers have begun to realize that emotions may be a key to consciousness. Neuroscientists like Dr. Antonio Damasio have found that when the link between the prefrontal lobe (which governs rational thought) and the emotional centers (e.g., the limbic system) is damaged, patients cannot make value judgments. They are paralyzed when making the simplest of decisions (what things to buy, when to set an appointment, which color pen to use) because everything has the same value to them. Hence, emotions are not a luxury; they are absolutely essential, and without them a robot will have difficulty determining what is important and what is not. So emotions, instead of being peripheral to the progress of artificial intelligence, are now assuming central importance. If a robot encounters a raging fire, it might rescue the computer files first, not the people, since its programming might say that valuable documents cannot be replaced but workers always can be. It is crucial that robots be programmed to distinguish between what is important and what is not, and emotions are shortcuts the brain uses to rapidly determine this. Robots would thus have to be programmed to have a value system—that human life is more important than material objects, that children should be rescued first in an emergency, that objects with a higher price are more valuable than objects with a lower price, etc. Since robots do not come equipped with values, a huge list of value judgments must be uploaded into them. The problem with emotions, however, is that they are sometimes irrational, while robots are mathematically precise. So silicon consciousness may differ from human consciousness in key ways. For example, humans have little control over emotions, since they happen so rapidly and because they originate in the limbic system, not the prefrontal cortex of the brain. Furthermore, our emotions are often biased.

Then there are the metabolic costs of switching itself that I wrote about earlier. Asking the brain to shift attention from one activity to another causes the prefrontal cortex and striatum to burn up oxygenated glucose, the same fuel they need to stay on task. And the kind of rapid, continual shifting we do with multitasking causes the brain to burn through fuel so quickly that we feel exhausted and disoriented after even a short time. We’ve literally depleted the nutrients in our brain. This leads to compromises in both cognitive and physical performance. Among other things, repeated task switching leads to anxiety, which raises levels of the stress hormone cortisol in the brain, which in turn can lead to aggressive and impulsive behaviors. By contrast, staying on task is controlled by the anterior cingulate and the striatum, and once we engage the central executive mode, staying in that state uses less energy than multitasking and actually reduces the brain’s need for glucose.

According to a recent study of the brains of identical and fraternal twins, differences in the amount of gray matter in the frontal lobes are not only genetically influenced but are significantly correlated with differences in intelligence.37 A study of Albert Einstein’s brain revealed that he had large, unusually shaped inferior parietal lobules, which participate in spatial reasoning and intuitions about number.38 Gay men are likely to have a smaller third interstitial nucleus in the anterior hypothalamus, a nucleus known to have a role in sex differences.39 And convicted murderers and other violent, antisocial people are likely to have a smaller and less active prefrontal cortex, the part of the brain that governs decision making and inhibits impulses.40 These gross features of the brain are almost certainly not sculpted by information coming in from the senses, which implies that differences in intelligence, scientific genius, sexual orientation, and impulsive violence are not entirely learned.

The brain makes up l/50th of our body mass but consumes a staggering 1/5th of the calories we burn for energy. If your brain were a car, in terms of gas mileage, it’d be a Hummer. Most of our conscious activity is happening in our prefrontal cortex, the part of our brain responsible for focus, handling short-term memory, solving problems, and moderating impulse control. It’s at the heart of what makes us human and the center for our executive control and willpower. The “last in, first out” theory is very much at work inside our head. The most recent parts of our brain to develop are the first to suffer if there is a shortage of resources. Older, more developed areas of the brain, such as those that regulate breathing and our nervous responses, get first helpings from our blood stream and are virtually unaffected if we decide to skip a meal. The prefrontal cortex, on the other hand, feels the impact. Unfortunately, being relatively young in terms of human development, it’s the runt of the litter come feeding time.

Philosophers and many proponents of cognitive psychology hold that moral judgments are within our control, and thus people who choose to commit crimes, barring delusions, know what they are doing and that it is wrong. The legal system depends on this notion. However, recent research suggests that damage to an area of the brain just behind the eyes can transform the way people make moral decisions. The results indicate that the ventromedial prefrontal cortex, implicated in the feeling of compassion, may be the foundation for moral regulations, assisting us in inhibiting (or not) harmful treatment of others. Failure in its development, or damage to it, might alter the way a person perceives the moral landscape, which will thus affect his or her actions. If juries include information of this kind in their deliberations, it could mitigate the harshness of the sentences they impose on convicted criminals. While more research must be done, other types of brain scans are being entered as evidence in the trials of some heinous crimes to show that the perpetrator could not help what he did.

But what separates human consciousness from the consciousness of animals? Humans are alone in the animal kingdom in understanding the concept of tomorrow. Unlike animals, we constantly ask ourselves “What if?” weeks, months, and even years into the future, so I believe that Level III consciousness creates a model of its place in the world and then simulates it into the future, by making rough predictions. We can summarize this as follows: Human consciousness is a specific form of consciousness that creates a model of the world and then simulates it in time, by evaluating the past to simulate the future. This requires mediating and evaluating many feedback loops in order to make a decision to achieve a goal. By the time we reach Level III consciousness, there are so many feedback loops that we need a CEO to sift through them in order to simulate the future and make a final decision. Accordingly, our brains differ from those of other animals, especially in the expanded prefrontal cortex, located just behind the forehead, which allows us to “see” into the future. Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest achievement of the human brain is its ability to imagine objects and episodes that do not exist in the realm of the real, and it is this ability that allows us to think about the future. As one philosopher noted, the human brain is an ‘anticipation machine,’ and ‘making the future’ is the most important thing it does.” Using brain scans, we can even propose a candidate for the precise area of the brain where simulation of the future takes place. Neurologist Michael Gazzaniga notes that “area 10 (the internal granular layer IV), in the lateral prefrontal cortex, is almost twice as large in humans as in apes. Area 10 is involved with memory and planning, cognitive flexibility, abstract thinking, initiating appropriate behavior, and inhibiting inappropriate behavior, learning rules, and picking out relevant information from what is perceived through the senses.” (For this book, we will refer to this area, in which decision making is concentrated, as the dorsolateral prefrontal cortex, although there is some overlap with other areas of the brain.)

Take the common Buddhist practice of “noting,” for example: practitioners learn to label their worries and feelings with a simple tag like “thinking” or “anger,” taking note of them mindfully without engaging them directly. In a 2007 study, the UCLA psychologist Matthew Lieberman showed thirty volunteers fear-provoking images and then asked them to note their feelings (“I feel afraid”) as he monitored their brain activity. Upon seeing the unpleasant images, the subjects’ amygdalae lit up at first, but the labeling process soon sparked activity in the right ventrolateral prefrontal cortex, damping activity in the amygdala. Lieberman believes this mindful noting—the simple act of putting our feelings into words—helps the brain disambiguate our emotions and provide a level of detachment from them. “One of the ways labeling is useful is in talking with other people,” he told me. “If you can get someone to talk about their feelings, it’ll end up being beneficial to them in ways they may not realize.” (Writing about how we feel in a journal serves the same purpose; it helps us sort out emotions, like anxiety, on a deeper subconscious level.)

The most obvious way that defensive motivational states make themselves known to us is, in fact, through our own behavior. The ability to observe one’s behavior and thus create representations of behavior in working memory is called monitoring.77 By directing our attention to our behavioral output, we can acquire information about what we are doing and intentionally adjust our behavior in light of thoughts, memories, and feelings. As an executive function of working memory, monitoring, not surprisingly, involves circuits in the prefrontal cortex.78 We use observations of our own behavior to regulate how we act in social situations.79 If you become aware that your behavior is negatively affecting others, you can make adjustments as a social situation evolves. Or if you notice you are acting in a biased way toward some group, you can make corrections. In addition, through monitoring one can observe undesirable habits and seek to change these through therapy or other means. Not everyone is equally adept at using monitoring to improve self-awareness. The field of emotional intelligence is all about how people differ in such abilities and how one can be trained to do better.80

There is real neurological evidence for the power of spiritual reflection to make us aware of our sin. Christians actually use a different part of their brain to self-evaluate than non-Christians. In a study conducted in Beijing, researchers compared which part of the brain people used to evaluate both themselves and others. The study is summarized in an article with the snappy title, “Neural Consequences of Religious Belief on Self-Referential Processing.” Non-religious subjects used one part of the brain (the ventral medial prefrontal cortex, in case you’re interested) to evaluate themselves, but another part (the dorsal medial prefrontal cortex) to evaluate others. Christians used the same part of the brain to evaluate themselves that they used to evaluate others. Researchers hypothesized this is because they were actually using a kind of “Jesus reference point” for self-evaluation; they were really asking, “What does God think of me?” UCLA researcher Jeff Schwartz said that this study is one of the most important scientific papers published in the last decade. Prayer, meditation, and confession actually have the power to rewire the brain in a way that can make us less self-referential and more aware of how God sees us. But

Brain imaging studies suggest that a couple brain areas in particular are involved in cognitive control: the anterior cingulate cortex (ACC) and the lateral prefrontal cortex (lateral PFC). We’ll be referring to these together as the “cognitive control regions” of the brain. There is still some debate about the precise role played by each of these regions, but one plausible characterization is that the ACC is a kind of smoke detector, and the lateral PFC is the fire response team. Like a smoke detector, the ACC is in constant monitoring mode, waiting to detect a whiff of danger, such as an instance of cognitive conflict. In the case of the Stroop task, we’ve got two automatic processes that are in conflict: the identification of a typeface or color versus the automatic processing of a simple word (assuming you’re literate and it’s your native language). This conflict alerts the ACC, which then sends out an alarm to the lateral PFC to come deal with the situation. The lateral PFC is responsible for many higher cognitive functions, such as the integration of conscious and unconscious knowledge, working memory (the small spotlight of consciousness that allows us to focus on explicit information), and conscious planning. Most relevantly, when it comes to the case of the Stroop task, the lateral PFC also exerts control over other areas of the brain by strengthening the activation of task-relevant networks at the expense of other networks. By weakening certain neural pathways, the lateral PFC essentially tells them to stop doing what they are doing, which is the neural equivalent of fire-retarding foam. In the Stroop task presented above,

Much of my research had stated that people with PTSD had shrunken prefrontal cortices—that experiencing triggers often shut down the logical centers of our brains and left us irrational and incapable of complex thought. But Siegle told me he’d discovered that research to be flawed. He’d found that with many people with complex PTSD, the exact opposite was happening. In moments of intense stress and trauma, our prefrontal cortices were actually far more active. Normally, if you’re facing a threat, your body immediately reacts to it. Your heart starts pumping blood. The hair on the back of your neck stands up. This is all in service of getting blood to your legs so you can run the hell away from it. On top of this, you feel your heart beating faster. You recognize that you’re freaking out. That makes you even more anxious, and your heart beats even faster. But Siegle told me, “As far as we can tell with complex PTSD, in really stressful situations, you’ve got this coping skill that allows the prefrontal cortex to just shut off some of our evolutionary freak-out mechanisms and instead have high levels of prefrontal activity. So our bodies stop reacting.” In other words, in some moments of intense stress, we are super-duper good at dissociation. Our hearts don’t pump as hard. Our brains cut themselves off from our bodies, so we don’t really have that feedback loop of getting anxious about getting anxious. Instead, our prefrontal cortices blink online—we become hyperrational. Super focused. Calm. Siegle explained it this way: “If running away has never been an option for you, you have to be cunning and do other things. So it’s like, this is time to bring all of our resources online, because we’re going to survive this.

Educated people, of course, know that perception, cognition, language, and emotion are rooted in the brain. But it is still tempting to think of the brain as it was shown in old educational cartoons, as a control panel with gauges and levers operated by a user — the self, the soul, the ghost, the person, the “me.” But cognitive neuroscience is showing that the self, too, is just another network of brain systems. [C]ognitive neuroscientists have not only exorcised the ghost but have shown that the brain does not even have a part that does exactly what the ghost is supposed to do: review all the facts and make a decision for the rest of the brain to carry out. Each of us feels that there is a single “I” in control. But that is an illusion that the brain works hard to produce, like the impression that our visual fields are rich in detail from edge to edge. The brain does have supervisory systems in the prefrontal lobes and anterior cingulate cortex, which can push the buttons of behavior and override habits and urges. But those systems are gadgets with specific quirks and limitations; they are not implementations of the rational free agent traditionally identified with the soul or the self.