Prefrontal Cortex Quotes

I did not know that my entire personality, my entire being, could be discarded as the byproduct of my anatomy. What if I really am just someone with a large prefrontal cortex...and nothing more?

The good part about having a mental disorder is having a valid reason for all the stupid things we do because of a damaged prefrontal cortex. However, the best part is seeing someone completely sane do the exact same things, without a valid excuse. This is the great equalizer of God and his little gift for all us crazy people to enjoy.

Meditation is blossoming of the prefrontal cortex to overcome the momentum of the nature. It is coming out of the loops of memories, patterns,fears, dreams and anger.

Mindfulness increases activation of the medial prefrontal cortex and decreases activation of structures like the amygdala that trigger our emotional responses. This increases our control over the emotional brain.

The warmth and satisfaction of positive contact with the adult is often just as good as a psychostimulant in supplying the child’s prefrontal cortex with dopamine.

The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school.

Multitasking has been found to increase the production of the stress hormone cortisol as well as the fight-or-flight hormone adrenaline, which can overstimulate your brain and cause mental fog or scrambled thinking. Multitasking creates a dopamine-addiction feedback loop, effectively rewarding the brain for losing focus and for constantly searching for external stimulation. To make matters worse, the prefrontal cortex has a novelty bias, meaning that its attention can be easily hijacked by something new—the proverbial shiny objects

How do we regulate our emotions? The answer is surprisingly simple: by thinking about them. The prefrontal cortex allows each of us to contemplate his or her own mind, a talent psychologists call metacognition. We know when we are angry; every emotional state comes with self-awareness attached, so that an individual can try to figure out why he's feeling what he's feeling. If the particular feeling makes no sense—if the amygdala is simply responding to a loss frame, for example—then it can be discounted. The prefrontal cortex can deliberately choose to ignore the emotional brain.

Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, the right area that plays a role in creative thought, emotions, formation of mental abstractions, and negative emotions.

Recent brain scans have shed light on how the brain simulates the future. These simulation are done mainly in the dorsolateral prefrontal cortex, the CEO of the brain, using memories of the past. On one hand, simulations of the future may produce outcomes that are desirable and pleasurable, in which case the pleasure centers of the brain light up (in the nucleus accumbens and the hypothalamus). On the other hand, these outcomes may also have a downside to them, so the orbitofrontal cortex kicks in to warn us of possible dancers. There is a struggle, then, between different parts of the brain concerning the future, which may have desirable and undesirable outcomes. Ultimately it is the dorsolateral prefrontal cortex that mediates between these and makes the final decisions. (Some neurologists have pointed out that this struggle resembles, in a crude way, the dynamics between Freud's ego, id, and superego.)

Indeed, brain scans done by scientists at Washington University in St. Louis indicate that areas used to recall memories are the same as those involved in simulating the future. In particular, the link between the dorsolateral prefrontal cortex and the hippocampus lights up when a person is engaged in planning for the future and remembering the past.

You can change dopamine and the dorsal striatum with exercise. You can boost serotonin with a massage. You can make decisions and set goals to activate the ventromedial prefrontal cortex. You can reduce amygdala activity with a hug and increase anterior cingulate activity with gratitude. You can enhance prefrontal norepinephrine with sleep.

Meditate. Neuroscientists have found that monks who spend years meditating actually grow their left prefrontal cortex, the part of the brain most responsible for feeling happy. But don’t worry, you don’t have to spend years in sequestered, celibate silence to experience a boost. Take just five minutes each day to watch your breath go in and out.

right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

The other way to train medics is to have them practice a skill so many times that it becomes automatic. So when the prefrontal cortex goes AWOL, when reasoning drops away, muscle memory, one hopes, will persist.

The prefrontal cortex takes in some outside information. The amygdala says I REMEMBER THAT! LAST TIME THAT SHIT HAPPENED, IT HURT! HURT SUCKS! And the brainstem tells the prefrontal cortex GET THE FUCK UP OUT OF THERE! WE DON’T LIKE TO HURT!

The adolescent brain makes important new pathways and connections, but the cognitive functions of the prefrontal cortex, the seat of judgment, don’t mature until around age twenty-five. (The emotional control functions follow at around thirty-two!)

The key arsenal of dark democracy is developing hatred and enmity towards the neighboring countries. Politicians do this just to block the prefrontal cortex or the wisdom brain of the mass and to activate the amygdala, the fear centers of the brain of the mass.

Bring your dopamine or adrenaline level down by activating other regions of the brain other than the prefrontal cortex.

Non-Conformity The path of non-conformity never takes the shortest distance between two points. It's convoluted like our prefrontal cortex.

Comparing the patterns of brain activity between the two conditions within the same individual, we discovered that supervisory regions in the prefrontal cortex required for thoughtful judgments and controlled decisions had been silenced in their activity by a lack of sleep.

War hysteria and dark nationalism deactivates the mass prefrontal cortex ( the rational brain ) and activates the amygdala ( the fear centers ). They are the key tools for dark democracy.

For many men, just seeing a woman in a sexually objectifying pose, such as in a bikini, deactivates the part of the brain's prefrontal cortex, the part of the brain where thinking about people and their intentions, feelings and actions happens. Instead, the region of the brain that lights up... is the one that reacts to looking at inanimate objects, such as a pen or a ball.

There is overwhelming evidence that meditation can increase focus and decrease anxiety, depression, and cortisol flooding. There is evidence that it decreases activation in the amygdala, one epicenter of fear in the brain, and increases activity in the prefrontal cortex. People who meditate are able to unstick themselves from cyclical, dangerous thinking and see things from a calmer, more positive perspective. The sympathetic nervous system, or the fight or flight system, is activated by stress. This is the system that gets us ready to run. The counter to this is the parasympathetic nervous system, the resting and digesting system. It lowers heart rate and blood pressure, slows breathing, and directly counters the stress response. Meditation activates the parasympathetic nervous system. It’s literally the antidote to stress. Plus, it’s what all the evolved, cool girls who look good without makeup are doing, according to social media.

Brain scans prove that patients who’ve sustained significant childhood trauma have brains that look different from people who haven’t. Traumatized brains tend to have an enlarged amygdala—a part of the brain that is generally associated with producing feelings of fear. Which makes sense. But it goes further than that: For survivors of emotional abuse, the part of their brain that is associated with self-awareness and self-evaluation is shrunken and thin. Women who’ve suffered childhood sexual abuse have smaller somatosensory cortices—the part of the brain that registers sensation in our bodies. Victims who were screamed at might have an altered response to sound. Traumatized brains can result in reductions in the parts of the brain that process semantics, emotion and memory retrieval, perceiving emotions in others, and attention and speech. Not getting enough sleep at night potentially affects developing brains’ plasticity and attention and increases the risk of emotional problems later in life. And the scariest factoid, for me anyway: Child abuse is often associated with reduced thickness in the prefrontal cortex, the part of the brain associated with moderation, decision-making, complex thought, and logical reasoning. Brains do have workarounds. There are people without amygdalae who don’t feel fear. There are people who have reduced prefrontal cortices who are very logical. And other parts of the brain can compensate, make up the lost parts in other ways. But overall, when I looked at the breadth of evidence, the results felt crushing. The fact that the brain’s cortical thickness is directly related to IQ was particularly threatening to me. Even if I wasn’t cool, or kind, or personable, I enjoyed the narrative that I was at least effective. Intelligent. What these papers seemed to tell me is that however smart I am, I’m not as smart as I could have been had this not happened to me. The questions arose again: Is this why my pitches didn’t go through? Is this why my boss never respected me? Is this why I was pushed to do grunt work in the back room?

It was as if the amygdala was the accelerator of defensive reactions and the prefrontal cortex the brake upon them (Figure 11.1). Malfunction of the brake makes the expression of the reactions hard to control. This idea has since been supported by research in animals and humans and is now commonly accepted.10

The warmth and satisfaction of positive contact with the adult is often just as good as a psychostimulant in supplying the child’s prefrontal cortex with dopamine. Greater security means less anxiety and more focused attention. The unseen factor that remains constant in all situations is the child’s unconscious yearning for attachment, dating back to the first years of life.

The neuroscientist Joseph LeDoux and his colleagues have shown that the only way we can consciously access the emotional brain is through self-awareness, i.e. by activating the medial prefrontal cortex, the part of the brain that notices what is going on inside us and thus allows us to feel what we’re feeling.5 (The technical term for this is “interoception”—Latin for “looking inside.”)

How poorly today’s North American way of life serves the needs of the human body may be gauged by the high levels of, say, heart disease, diabetes and obesity on this continent. The situation of the human brain is analogous. The miswired ADD circuits of the prefrontal cortex are as much the effect of unhealthful circumstances as are the cholesterol-plugged arteries of atherosclerotic coronary disease.

In brain scans, music lights up the medial prefrontal cortex and triggers a memory that starts playing in your mind. All of a sudden you can see a place, a person, an incident. The strongest responses to music—the ones that elicit vivid memories—cause the greatest activity on brain scans.

Scientists have learned that animals that experience prolonged stress have less activity in the parts of their brain that handle higher-order tasks—for example, the prefrontal cortex—and more activity in the primitive parts of their brain that are focused on survival, such as the amygdala.

There will come a time when a person you most likely pushed out through your vagina and nursed from your nipples, whose bottom you wiped, and whose snot and spit you cleaned up over several sleep-starved years will apprehend you with a mixture of boredom and irritation and say, ‘Get a life, Mum.’ This would be a good time to remember that a) violence never solved anything; b) teenagers don’t have a full brain yet – the prefrontal cortex that controls the ability to make important distinctions, like who controls the pocket money, only kicks in around the age of twenty-four; and c) you are, in fact, the adult.

Here’s how to get started: 1. Sit still and stay put . Sit in a chair with your feet flat on the ground, or sit cross-legged on a cushion. Sit up straight and rest your hands in your lap. It’s important not to fidget when you meditate—that’s the physical foundation of self-control. If you notice the instinct to scratch an itch, adjust your arms, or cross and uncross your legs, see if you can feel the urge but not follow it. This simple act of staying still is part of what makes meditation willpower training effective. You’re learning not to automatically follow every single impulse that your brain and body produce. 2. Turn your attention to the breath. Close your eyes or, if you are worried about falling asleep, focus your gaze at a single spot (like a blank wall, not the Home Shopping Network). Begin to notice your breathing. Silently say in your mind “inhale” as you breathe in and “exhale” as you breathe out. When you notice your mind wandering (and it will), just bring it back to the breath. This practice of coming back to the breath, again and again, kicks the prefrontal cortex into high gear and quiets the stress and craving centers of your brain . 3. Notice how it feels to breathe, and notice how the mind wanders. After a few minutes, drop the labels “inhale/exhale.” Try focusing on just the feeling of breathing. You might notice the sensations of the breath flowing in and out of your nose and mouth. You might sense the belly or chest expanding as you breathe in, and deflating as you breathe out. Your mind might wander a bit more without the labeling. Just as before, when you notice yourself thinking about something else, bring your attention back to the breath. If you need help refocusing, bring yourself back to the breath by saying “inhale” and “exhale” for a few rounds. This part of the practice trains self-awareness along with self-control. Start with five minutes a day. When this becomes a habit, try ten to fifteen minutes a day. If that starts to feel like a burden, bring it back down to five. A short practice that you do every day is better than a long practice you keep putting off to tomorrow. It may help you to pick a specific time that you will meditate every day, like right before your morning shower. If this is impossible, staying flexible will help you fit it in when you can.

Since then neuroscience research has shown that we possess two distinct forms of self-awareness: one that keeps track of the self across time and one that registers the self in the present moment. The first, our autobiographical self, creates connections among experiences and assembles them into a coherent story. This system is rooted in language. Our narratives change with the telling, as our perspective changes and as we incorporate new input. The other system, moment-to-moment self-awareness, is based primarily in physical sensations, but if we feel safe and are not rushed, we can find words to communicate that experience as well. These two ways of knowing are localized in different parts of the brain that are largely disconnected from each other.10 Only the system devoted to self-awareness, which is based in the medial prefrontal cortex, can change the emotional brain. In the groups I used to lead for veterans, I could sometimes see these two systems working side by side. The soldiers told horrible tales of death and destruction, but I noticed that their bodies often simultaneously radiated a sense of pride and belonging.

(When we force a smile, we activate facial muscles with our prefrontal cortex. But when we smile because we are in a good mood, our nerves are controlled by our limbic system, which activates a slightly different set of muscles. Our brains can tell the subtle difference between the two, which was beneficial for our evolution.)

The right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

Given that the pre-frontal cortex is a key to our success as a species, consuming any amount of alcohol or other intoxicant seems really stupid.

Interestingly, pathological liars have atypically large amounts of white matter in the prefrontal cortex, indicating more complex wiring.

With the prefrontal cortex down-regulated, most impulse control mechanisms go offline too. For people who aren't used to this combination, the results can be expensive.

Certainly the prefrontal cortex is an important thing; I’m as proud of mine as the next guy.

Our problem-scanning machine (amygdala) and our serenity-now mood tape (prefrontal cortex) are at war.

The functioning of the prefrontal cortex is inhibited by alcohol, which can lead to sudden, mindless violence after a night out.

dorsal prefrontal cortex is critically involved in preparing, deciding, and planning for the future.

Robert Sapolsky, a neurobiologist at Stanford University, has argued that the main job of the modern prefrontal cortex is to bias the brain—and therefore, you—toward doing “the harder thing.” When it’s easier to stay on the couch, your prefrontal cortex makes you want to get up and exercise. When it’s easier to say yes to dessert, your prefrontal cortex remembers the reasons for ordering tea instead. And when it’s easier to put that project off until tomorrow, it’s your prefrontal cortex that helps you open the file and make progress anyway.

When my father was a soldier, his prefrontal cortex wasn’t yet complete. He could not grow a full mustache, and when he came back home he had a cane and a DIY tattoo of a woman’s name.

the prefrontal cortex has a novelty bias, meaning that its attention can be easily hijacked by something new—the proverbial shiny objects we use to entice infants, puppies, and kittens.

How you think about your stress is important. Your prefrontal cortex has the ability to ramp up your amygdala with panicky, negative thoughts or calm it down with calming and optimistic thoughts.

Artists and visionaries are right about cannabis’s mind-expanding properties. Cannabis causes the prefrontal cortex to release a hormone called dopamine, which can help you tap into your creative side.

People who are very Tuned In to context tend to have strong connections from the hippocampus to areas in the prefrontal cortex that control executive functions and that hold long-term memories in the neocortex.

they arouse the inhibitory function. They wake up the cop, alert the underdeveloped and underactive circuitry of the prefrontal cortex. Recognizing that ADD is a problem of development rather than one of pathology

In fact, a recent fMRI study shows that when people use self-talk to reassess upsetting situations, activity in their prefrontal cortex increases in an amount correlated with a decrease of activity in their amygdala.

WILLPOWER EXPERIMENT: BREATHE YOUR WAY TO SELF-CONTROL You won’t find many quick fixes in this book, but there is one way to immediately boost willpower: Slow your breathing down to four to six breaths per minute. That’s ten to fifteen seconds per breath—slower than you normally breathe, but not difficult with a little bit of practice and patience. Slowing the breath down activates the prefrontal cortex and increases heart rate variability, which helps shift the brain and body from a state of stress to self-control mode. A few minutes of this technique will make you feel calm, in control, and capable of handling cravings or challenges.4 It’s

Stanford psychologist Laura Carstensen, to name one such example, used an fMRI scanner to study the brain behavior of subjects presented with both positive and negative imagery. She found that for young people, their amygdala (a center of emotion) fired with activity at both types of imagery. When she instead scanned the elderly, the amygdala fired only for the positive images. Carstensen hypothesizes that the elderly subjects had trained the prefrontal cortex to inhibit the amygdala in the presence of negative stimuli. These elderly subjects were not happier because their life circumstances were better than those of the young subjects; they were instead happier because they had rewired their brains to ignore the negative and savor the positive. By skillfully managing their attention, they improved their world without changing anything concrete about it.

In neurochemical terms, when he feels threatened or thwarted, Trump moves into a fight-or-flight state. His amygdala is triggered, his hypothalamic-pituitary-adrenal axis activates, and his prefrontal cortex—the part of the brain that makes us capable of rationality and reflection—shuts down. He reacts rather than reflects, and damn the consequences. This is what makes his access to the nuclear codes so dangerous and frightening.

Without sleep, however, the strong coupling between these two brain regions is lost. We cannot rein in our atavistic impulses—too much emotional gas pedal (amygdala) and not enough regulatory brake (prefrontal cortex).

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

In the human species, the peak of synaptic overproduction ends around two years of age in the visual cortex, three or four years of age in the auditory cortex, and between five and ten years of age in the prefrontal cortex.

(The production of myelin by OPCs in the brains of infants and children helps explain how they do smart things; the incomplete myelination of the prefrontal cortex in the brains of teens helps explain why they do stupid things.)

Throughout the human life span there remains a constant two-way interaction between psychological states and the neurochemistry of the frontal lobes, a fact that many doctors do not pay enough attention to. One result is the overreliance on medications in the treatment of mental disorders. Modern psychiatry is doing too much listening to Prozac and not enough listening to human beings; people’s life histories should be given at least as much importance as the chemistry of their brains. The dominant tendency is to explain mental conditions by deficiencies of the brain’s chemical messengers, the neurotransmitters. As Daniel J. Siegel has sharply remarked, “We hear it said everywhere these days that the experience of human beings comes from their chemicals.” Depression, according to the simple biochemical model, is due to a lack of serotonin — and, it is said, so is excessive aggression. The answer is Prozac, which increases serotonin levels in the brain. Attention deficit is thought to be due in part to an undersupply of dopamine, one of the brain’s most important neurotransmitters, crucial to attention and to experiencing reward states. The answer is Ritalin. Just as Prozac elevates serotonin levels, Ritalin or other psychostimulants are thought to increase the availability of dopamine in the brain’s prefrontal areas. This is believed to increase motivation and attention by improving the functioning of areas in the prefrontal cortex. Although they carry some truth, such biochemical explanations of complex mental states are dangerous oversimplifications — as the neurologist Antonio Damasio cautions: "When it comes to explaining behavior and mind, it is not enough to mention neurochemistry... The problem is that it is not the absence or low amount of serotonin per se that “causes” certain manifestations. Serotonin is part of an exceedingly complicated mechanism which operates at the level of molecules, synapses, local circuits, and systems, and in which sociocultural factors, past and present, also intervene powerfully. The deficiencies and imbalances of brain chemicals are as much effect as cause. They are greatly influenced by emotional experiences. Some experiences deplete the supply of neurotransmitters; other experiences enhance them. In turn, the availability — or lack of availability — of brain chemicals can promote certain behaviors and emotional responses and inhibit others. Once more we see that the relationship between behavior and biology is not a one-way street.

A little brain science: ADHD primarily affects our prefrontal cortex, the seat of our executive functions. This part of the brain controls what we pay attention to, how we respond, and what thoughts have the floor at any given time.[2]

The more dopamine a drug releases in the brain’s reward pathway (a brain circuit that links the ventral tegmental area, the nucleus accumbens, and the prefrontal cortex), and the faster it releases dopamine, the more addictive the drug.

When you tap into the arts to foster a meditative state, the places in your brain responsible for judgment and personal criticism are quieted in your prefrontal cortex, and you can assess a more generous, perspective-taking point of view.

(For example, all of us talk to ourselves silently. When we do, the left brain, which controls language, consults the prefrontal cortex. But in schizophrenics, we now know, the left brain activates without permission from the prefrontal cortex,

The infestation,” Dr. Pam says. She presses a button and zooms in on the front part of Chris’s brain. The pukish color intensifies, glowing neon bright. “This is the prefrontal cortex, the thinking part of the brain—the part that makes us human.

By physically moving instead of stopping to think, the physiology changes and the mind follows suit. It activates the prefrontal cortex or the part of the brain that enables a person to focus so that he/she can change or take deliberate actions.

The dorsal striatum says, “Let’s do it this way, because we’ve always done it this way.” And the prefrontal cortex says, “But that won’t help us get where we want to go.” Meanwhile, the nucleus accumbens says, “Ooh, that cupcake looks delicious.

Each time we check a Twitter feed or Facebook update, we encounter something novel and feel more connected socially (in a kind of weird impersonal cyber way) and get another dollop of reward hormones. But remember, it is the dumb, novelty-seeking portion of the brain driving the limbic system that induces this feeling of pleasure, not the planning, scheduling, higher-level thought centers in the prefrontal cortex. Make no mistake: E-mail, Facebook, and Twitter checking constitute a neural addiction

The prefrontal cortex chooses what to do based on what’s good for us in the long term. The nucleus accumbens chooses what to do based on what’s the most immediately pleasurable. And the dorsal striatum chooses what to do based on what we’ve done before.

the neural basis of grit in the brain identified a tiny region in the right prefrontal cortex, which other studies have found to be involved in self-regulation, planning, goal setting, and thinking about how past failures could have been turned to successes.

The ability to control our focus—also called top-down attentional control—relies on the prefrontal cortex. It is the last part of the brain to develop, and it develops even more slowly in those with ADHD. And even once it is fully developed, it’s still impaired.

Mischel’s next step made his studies iconic — he tracked the kids forward, seeing if marshmallow wait time predicted anything about their adulthoods . [...] Five-year-old champs at marshmallow patience averaged higher SAT scores in high school (compared with those who couldn’t wait). [...] Forty years post-marshmallow, they excelled at frontal function, had more PFC [Prefrontal cortex] activation during a frontal task, and had lower BMIs. A gazillion-dollar brain scanner doesn’t hold more predictive power than one marshmallow.

the parts of the brain corresponding to the limbic system (thought to respond only to more visceral, immediate rewards) were activated only when the decision involved comparing a reward today with one in the future. In contrast, the lateral prefrontal cortex (a more “calculating” part of the brain) responded with a similar intensity to all decisions, regardless of the timing of the options. Brains that work like this would produce a lot of failed good intentions. And indeed, we do see a lot of those, from New Year’s resolutions to gym memberships that lie unused.

they found considerable plasticity from the onset of puberty into the early twenties. Once this was discovered, it became obvious that the upheavals of adolescence and early adulthood coincide with a previously unrecognized sensitive period of brain maturation in the prefrontal cortex

Often when we try to start a good habit and then slip up, we describe it as a failure of willpower. But sticking to a good habit is not simply a matter of willpower. You have willpower only insofar as your prefrontal cortex is paying attention and has enough serotonin to work properly.

Kris was in black running shorts and a tight gray T-shirt constructed from some sort of magical material that clung to his muscles and triggered a gush of epinephrine while her amygdala attempted to reconcile two conflicting signals from her prefrontal cortex: attraction and revenge. “All

Classifying depression as an illness serves the psychiatric community and pharmaceutical corporations well; it also soothes the frightened, guilty, indifferent, busy, sadistic, and unschooled. To understand depression as a call for life-changes is not profitable. Stagnation is not a medical term. The 17.5 million Americans diagnosed as suffering a major depression in 1997 were mostly damned. (Psychobiological examinations confuse cause and symptom.) Deficient serotonergic functioning, ventral prefrontal cerebral cortex, dis-inhibition of impulsive-aggressive behavior, blah blah blah: the medical lexicon boils emotion from human being. Go take a drug, the doctor says. Pain is a biochemical phenomenon. Erase all memory.

Stay in the now. Pay attention to the things that are happening now, and don’t pay attention to the things that aren’t happening now. Focusing on the present helps reduce anxiety and worry, because it decreases emotional, self-focused processing in the ventromedial prefrontal cortex. Attention to the present also increases dorsolateral and ventrolateral prefrontal activity, allowing these regions to calm the amygdala.15 Improving your ability to stay present, a practice known as “mindfulness,” helps enhance these activations and leads to long-term improvements in anxiety and worrying.

efficiently means providing slots in our schedules where we can maintain an attentional set for an extended period. This allows us to get more done and finish up with more energy. Related to the manager/worker distinction is that the prefrontal cortex contains circuits responsible for telling us whether we’re controlling something or someone else is. When we set up a system, this part of the brain marks it as self-generated. When we step into someone else’s system, the brain marks it that way. This may help explain why it’s easier to stick with an exercise program or diet that someone else sets up: We typically trust them as “experts” more than we trust ourselves. “My trainer told me to do three sets of ten reps at forty pounds—he’s a trainer, he must know what he’s talking about. I can’t design my own workout—what do I know?” It takes Herculean amounts of discipline to overcome the brain’s bias against self-generated motivational systems. Why? Because as with the fundamental attribution error we saw in Chapter 4, we don’t have access to others’ minds, only our own. We are painfully aware of all the fretting and indecision, all the nuances of our internal decision-making process that led us to reach a particular conclusion. (I really need to get serious about exercise.) We don’t have access to that (largely internal) process in others, so we tend to take their certainty as more compelling, in many cases, than our own. (Here’s your program. Do it every day.)

Attentional amplification of sensory awareness in any sensory medium is achieved by top-down signals from prefrontal cortex that modulate activity of single neurons in sensory brain areas in the absence of any sensory stimulation and significantly increase baseline activity in the corresponding target region.

I theorize that humans are different from animals because we understand time. We have temporal consciousness in addition to spatial and social consciousness. The latest part of the brain to evolve is the prefrontal cortex, which lies just behind our forehead. It is constantly running simulations of the future.

dopamine is used to measure the addictive potential of any behavior or drug. The more dopamine a drug releases in the brain’s reward pathway (a brain circuit that links the ventral tegmental area, the nucleus accumbens, and the prefrontal cortex), and the faster it releases dopamine, the more addictive the drug.

Suppose you unexpectedly see a person you care about. Suddenly you feel the love you have, for that person. Let's follow the flow of information from the visual system through the brain to the point of the experience of love as best we can. First of all, the stimulus will flow from the visual system to the prefrontal cortex (putting an image of the loved one in working memory). The stimulus also reaches the explicit memory system of the temporal lobe and activates memories and integrates them with the image of the person. Simultaneously with these processes, the subcortical areas presumed to be involved in attachment will be activated (the exact paths by which the stimulus reaches these areas is not known, however). Activation of attachment circuits then impacts on working memory in several ways. One involves direct connections from the attachment areas to the prefrontal cortex (as with fear, it is the medial prefrontal region that is connected with subcortical attachment areas). Activation of attachment circuits also leads to activation of brain stem arousal networks, which then participate in the focusing of attention on the loved one by working memory. Bodily responses will also be initiated as outputs of attachment circuits, and contrast with the alarm responses initiated by fear and stress circuits. We approach rather than try to escape from or avoid the person, and these behavioral differences are accompanied by different physiological conditions within the body. This pattern of inputs to working memory from within the brain and from the body biases us more toward an open and accepting mode of processing than toward tension and vigilance. The net result in working memory is the feeling of love.

So you don’t have an inner lizard or an emotional beast-brain. There is no such thing as a limbic system dedicated to emotions. And your misnamed neocortex is not a new part; many other vertebrates grow the same neurons that, in some animals, organize into a cerebral cortex if key stages run for long enough. Anything you read or hear that proclaims the human neocortex, cerebral cortex, or prefrontal cortex to be the root of rationality, or says that the frontal lobe regulates so-called emotional brain areas to keep irrational behavior in check, is simply outdated or woefully incomplete. The triune brain idea and its epic battle between emotion, instinct, and rationality is a modern myth.

Neuroscientists have determined the brain’s dorsolateral prefrontal cortex is associated with decision making and cost-benefit assessments. If MRI brain scans had been performed on my friends and me one summer’s night when we were fifteen, they would have revealed a dark spot indicating a complete absence of activity in this region of our brains.

Fortunately, suppressing an impulse doesn’t always have to decrease your dopamine—it can actually feel good. The key is the prefrontal cortex, which is responsible for pursuing long-term goals and has the ability to modulate dopamine release in the nucleus accumbens. So suppressing an impulse can be rewarding, as long as it’s in service of your larger values.

is managed by a section of the frontal lobe called the prefrontal cortex, or PFC. Just like it sounds, the PFC is the most forward-facing part of the frontal lobe. This is where some of our most human faculties lie: planning, personality, rule learning, and other “executive” functions that permit us to live in a complex, nuanced world pummeling us with stimuli.

Each of us—whether a loved daughter or not—has experienced hurts, slights, and disappointments that, even if half-forgotten or mostly unseen, remain remembered and a part of us nonetheless. Sometimes they are rooted in the deep past but, equally, they may be part of the lived present, and there may be moments when our own unresolved feelings may endanger the equilibrium of our relationships with our daughters. From the point of view of brain science, whether we address those feelings from what Siegel and Hartzell call the “high road”—the powers of reflection embedded in the prefrontal cortex of the brain—or the “low road”—automatic responses embedded in the past applied to the situation at hand—will make all the difference.

So you aren’t still in love with her?” I ask, eyebrows up, curious. “You’re over it? Over her? Sayonara, Daisy—” “Well—” His brows bend in the middle. BJ gives me a gentle but firm smile. “Magnolia.” “Oh—” I look at my fiancé. “Too much?” He gives me a tight smile. “You could try not talking for twenty seconds. See what happens.” I don’t do that. Instead I give Tiller an apologetic smile. “See, I was recently diagnosed with ADHD—” “Oh.” Tiller nods, not knowing what to say. “It impairs my prefrontal cortex—something about a neurotransmitter in the brain and then also lower levels of dopamine—which is so rude—don’t you think that’s so rude? Dopamine’s pretty nice—my doctor said it’s probably why I love shopping so much. And sex—

You never want one thing at any given moment of life. Your mind always comes up with at least two choices. If your limbic system wins, the choice you make seems to be pleasurable at first but in the long run ends up being the wrong one. And if your prefrontal cortex wins the choice you make may appear rough at first, but in the long run it turns out to be the right one.

Notice what you notice. You can’t control the random bits of information that pop into your head. But you can start to notice your biases. When you get annoyed that you’re stuck at a red light think, Oh, that’s interesting. I noticed this red light, but I didn’t notice the last green light I made. In short, try practicing nonjudgmental awareness. Nonjudgmental awareness is a form of mindfulness that simply means noticing without reacting emotionally, even when things don’t turn out as you expected. Awareness does not require emotion, because emotion and awareness are mediated by different brain regions. Noticing a mistake might automatically trigger the emotional amygdala, but becoming aware of your own reaction activates the prefrontal cortex, which calms the amygdala.

Scientists call this shutdown7 “transient hypofrontality.” Transient means temporary. “Hypo,” the opposite of “hyper,” means “less than normal.” And frontality refers to the prefrontal cortex, the part of our brain that generates our sense of self. During transient hypofrontality, because large swatches of the prefrontal cortex turn off, that inner critic comes offline. Woody goes quiet.

Some people have more highly activated left prefrontal cortexes and some people have more highly activated right prefrontal cortexes. (This has nothing to do with the question of hemispheric dominance that determines whether you are right-handed or left-handed, which occurs in other areas of the brain.) The majority of people have higher left-side activation. People with higher right-side activation tend to experience more negative emotion than people with higher left-side activation. Right-side activation also predicts how easily someone’s immune system will become depressed. The right-brain activation is also correlated with high baseline levels of cortisol, the stress hormone. Though the settled patterns of activation do not stabilize until adulthood, babies with greater right-side activation will become frantic when their mothers leave a room; babies with strong left-side activation will be more likely to explore the room without apparent distress. In babies, however, the balance is subject to change. “The likelihood,” Davidson says, “is that there’s more plasticity in the system in the early years of life, more opportunity for the environment to sculpt this circuitry.

The amygdala plays an important role in the acquisition, storage, expression, and extinction of threat memories. The ventromedial prefrontal cortex (PFCVM) regulates the acquisition, storage, expression, and extinction of threat memories by the amygdala. The hippocampus learns about the context of acquisition and modulates the expression and extinction of threat memories in relation to context.

The frontal lobe has connections to other parts of the brain and can inhibit those parts, giving humans the ability to stop and think and divert primitive responses.160 Humans don’t have to follow every impulse from their brains, and the prefrontal cortex is vitally important in this ability. The prefrontal cortex has the greatest role in inhibiting behavior and withholding automatic responses.161

Compounding this is the fact that the brain’s prefrontal cortex—the large part of the forebrain that lets us plan, think logically, and get work done—has a built-in “novelty bias.” Whenever we switch between tasks, it rewards us with dopamine—that amazing pleasure chemical that rushes through our brain whenever we devour a medium-sized pizza, accomplish something awesome, or have a drink or two after work.

Brain scans prove that patients who’ve sustained significant childhood trauma have brains that look different from those of people who haven’t.[8] Traumatized brains tend to have an enlarged amygdala—a part of the brain that is generally associated with producing feelings of fear. Which makes sense. But it goes further than that: For survivors of emotional abuse, the part of their brain that is associated with self-awareness and self-evaluation is shrunken and thin. Women who’ve suffered childhood sexual abuse have smaller somatosensory cortices—the part of the brain that registers sensation in our bodies. Victims who were screamed at might have an altered response to sound. Trauma can result in reductions in the parts of the brain that process semantics, emotion and memory retrieval, perceiving emotions in others, and attention and speech. Not getting enough sleep at night potentially affects developing brains’ plasticity and attention and increases the risk of emotional problems later in life. And the scariest factoid, for me anyway: Child abuse is often associated with reduced thickness in the prefrontal cortex, the part of the brain associated with moderation, decision-making, complex thought, and logical reasoning.

The explanations may help us understand the parts of the brain that made a behavior tempting, but they say nothing about the other parts of the brain (primarily in the prefrontal cortex) that could have inhibited the behavior by anticipating how the community would respond to it. [...] Why should we discard our lever on the system for inhibition just because we are coming to understand the system for temptation?

The limbic system is responsible for anxiety itself, but the pre-frontal cortex provides the worry scripts, formulating potential problems. When our mind races and catastrophizes, that’s the pre-frontal cortex.

transient hypofrontality removes our sense of self. With parts of the prefrontal cortex deactivated, there’s no risk assessor, future predictor, or inner critic around to monitor the situation. The normal safety measures kept in place by the conscious mind are no longer. This is another reason why flow states significantly enhance performance: when the “self” disappears, it takes many of our limits along for the ride.

of the diverse systems within our brains. Optimal sculpting of the prefrontal cortex through healthy early relationships allows us to think well of ourselves, trust others, regulate our emotions, maintain positive expectations, and utilize our intellectual and emotional intelligence in moment-to-moment problem solving. We can now add a corollary to Darwin’s survival of the fittest: Those who are nurtured best survive best.

Soft power. When you need to speak up, be artful. Take care of your partner as best you can by explicitly cherishing them and your relationship. Start by letting them know you need repair, is this a good time? If your partner agrees to talk, thank them, start off with an appreciation - something you are thankful for that your partner has said or done, even if it's just that you appreciate their willingness to sit down and talk. Then state your intentions - a good thing to do generally: "I want to clear the air between us so that I can feel closer to you." Center yourself in your Wise Adult, prefrontal cortex, and remember love. Recall that the person you're addressing is someone you love, or at least care for, and in any case, you will have to live with them. Remembering love is a recentering practice. You're speaking to someone you care about in the hopes of making things better.

If you are one of those people who can’t hold a lot in mind at once—you lose focus and start daydreaming in lectures, and have to get to someplace quiet to focus so you can use your working memory to its maximum—well, welcome to the clan of the creative. Having a somewhat smaller working memory means you can more easily generalize your learning into new, more creative combinations. Because you’re learning new, more creative combinations. Having a somewhat smaller working memory, which grows from the focusing abilities of the prefrontal cortex, doesn’t lock everything up so tightly, you can more easily get input from other parts of your brain. These other areas, which include the sensory cortex, not only are more in tune with what’s going on in the environment, but also are the source of dreams, not to mention creative ideas. You may have to work harder sometimes (or even much of the time) to understand what’s going on, but once you’ve got something chunked, you can take that chunk and turn it outside in and inside round—putting it through creative paces even you didn’t think you were capable of! Here’s another point to put into your mental chunker: Chess, that bastion of intellectuals, has some elite players with roughly average IQs. These seemingly middling intellects are able to do better than some more intelligent players because they practice more. That’s the key idea. Every chess player, whether average or elite, grows talent by practicing. It is the practice—particularly deliberate practice on the toughest aspects of the material—that can help lift average brains into the realm of those with more “natural” gifts. Just as you can practice lifting weights and get bigger muscles over time, you can also practice certain mental patterns that deepen and enlarge in your mind.

So for James, too, will derives not from the freedom to initiate thoughts, but to focus on and select some while stifling, blocking-or vetoing-others. For Buddhist mindfulness practice, it is the moment of restraint that allows mindful awareness to take hold and deepen. The essence of directed mental force is first to stop the grinding machine-like automaticity of the urge to act. Only then can the wisdom of the prefrontal cortex be actively engaged.

Collectively this work suggests that the prefrontal cortex and the amygdala are reciprocally related. That is, in order for the amygdala to respond to fear reactions, the prefrontal region has to be shut down. By the same logic, when the prefrontal region is active, the amygdala would be inhibited, making it harder to express fear. Pathological fear, then, may occur when the amygdala is unchecked by the prefrontal cortex, and treatment of pathological fear may require that the patient learn to increase activity in the prefrontal region so that the amygdala is less free to express fear. Clearly, decision-making ability in emotional situations is impaired in humans with damage to the medial and ventral prefrontal cortex, and abnormalities there also may predispose people to develop fear and anxiety disorders. These abnormalities could be due to genetic or epigenetic organization of prefrontal synapses or to experiences that subtly alter prefrontal synaptic connections. Indeed, the behavior of animals with abmormalities of the medial prefrontal cortex is reminiscent of humans with anxiety disorders: they develop fear reactions that are difficult to regulate. Although objective information about the world may indicate that a situation is not dangerous, because they cannot properly regulate fear circuits, they experience fear and anxiety in these safe situations.

Anything perceived as a threat trips the amygdala—the brain’s hand-wringing sentry—to set in motion the biochemical cascade known as the fight-or-flight response. Bruce Siddle, who consults in this area and sits on the board of Strategic Operations, prefers the term “survival stress response.” Whatever you wish to call it, here is a nice, concise summary, courtesy of Siddle: “You become fast, strong, and dumb.” Our hardwired survival strategy evolved back when threats took the form of man-eating mammals, when hurling a rock superhumanly hard or climbing a tree superhumanly fast gave you the edge that might keep you alive. A burst of adrenaline prompts a cortisol dump to the bloodstream. The cortisol sends the lungs into overdrive to bring in more oxygen, and the heart rate doubles or triples to deliver it more swiftly. Meanwhile the liver spews glucose, more fuel for the feats at hand. To get the goods where the body assumes they’re needed, blood vessels in the large muscles of the arms and legs dilate, while vessels serving lower-priority organs (the gut, for example, and the skin) constrict. The prefrontal cortex, a major blood guzzler, also gets rationed. Good-bye, reasoning and analysis. See you later, fine motor skills. None of that mattered much to early man. You don’t need to weigh your options in the face of a snarling predator, and you don’t have time.

But young children, whose prefrontal cortexes have barely begun to ripen, can’t conceive of a future, which means they spend their lives in the permanent present, a forever feeling of right now. At times, this is a desirable state of consciousness; indeed, for meditators, it’s the ultimate aspiration. But living in the permanent present is not a practical parenting strategy. “Everybody would like to be in the present,” says Daniel Gilbert, a social psychologist at Harvard and author of the 2006 best-seller Stumbling on Happiness. “Certainly it’s true that there is an important role for being present in our lives. All the data say that. My own research says that.” The difference is that children, by definition, only live in the present, which means that you, as a parent, don’t get much of a chance. “Everyone is moving at the same speed toward the future,” he says. “But your children are moving at that same speed with their eyes closed. So you’re the ones who’ve got to steer.” He thinks about this for a moment. “You know, back in the early seventies, I hung out with a lot of people who wanted to live in the present. And it meant that no one paid the rent.” In effect, parents and small children have two completely different temporal outlooks. Parents can project into the future; their young children, anchored in the present, have a much harder time of it. This difference can be a formula for heartbreak for a small child.

young adults look fully grown, and their intellectual powers—their capacity for making rapid calculations and forming long-term memories—will never get better. But most young people reach their college years, like me, with plenty of growing still to do. Their decision-making and judgment lag behind. And that’s not just because of a lack of experience. As neuroscientists have discovered, the brain—and in particular the prefrontal cortex—does not fully mature until our late twenties.

In a sense, yes, but I have another concern that is a more imminent threat that is occupying the vast majority of my prefrontal cortex." "I'm guessing that's part of the brain." "In rudimentary terms it's the area of the brain where we make decisions." Brandon scrunched up his face and pressed his finger into his cheek. "What does rudimentary mean?" "It means--" "I'm kidding, Professor." Brandon laughed and punched Marcus playfully in the arm. "I did go to school for a few years, you know.

There are as many paths to success (and failure) as there are human beings. The smarter you are, the better your chances. The more emotionally balanced, the better. The grittier your determination to overcome obstacles and the longer you practice, the better you’ll do. And even if the frontal lobe or a kernel of the right prefrontal cortex plays essential roles in enhancing these abilities, the bottom line is that to achieve maximum results, the entire brain must work together as a harmonious, integrated whole.

Hiking calms. According to a study published in the Proceedings of the National Academy of Sciences, a ninety-minute walk through a natural area led to lower levels of brooding and obsessive worry. Brain scans of the subjects found that there was decreased blood flow to the subgenual prefrontal cortex. Increased blood flow to this region of the brain is associated with bad moods. Everything from feeling sad about something, to worrying, to major depression seems to be tied to this brain region. Hiking deactivates it.

The prefrontal cortex is a complex, fragile region of the brain. In its healthy state, it directs human impulses toward rational choices and away from destructive or self destructive behavior. It allows us to deal with the present moment while storing plans for the future. Yet as the newest part of the brain to develop in human evolution, the prefrontal cortex is also the region that takes the longest time to reach maturity, or maximum operating efficiency. It will not be fully functional until the person is past the age of twenty.

Stress changes the dynamics of the conversation. When you’re calm and relaxed, your prefrontal cortex is pretty good at getting its way. But the more anxious or stressed you get, the more the power shifts to the dorsal striatum and nucleus accumbens. That’s why you might be doing fine on your diet until you get in a fight with your significant other. Or you might be exercising regularly until family drama raises its ugly head. When stressed, you usually act out your most deeply engrained routines or become a victim to your impulses.

Neuronal maturity doesn’t happen at the same pace across the human brain. Some regions are completed much earlier than others, and the frontal lobes are the last to receive the finishing touches. The prefrontal cortex of the brain, the most complicated region, which provides us with cognition and judgment, demands the most sculpting. The final step in making a neuron work optimally is to have the long axonal cables wrapped in a fatty insulation from the surrounding glia, a process called myelination. Only then is the brain fully grown.

evidence from functional magnetic resonance imaging showing that patients with BPD have hyperactivity in the limbic areas of the brain, especially the amygdala, and hypoactivity in the prefrontal cortex [and] in complex interaction with childhood trauma common among borderline patients, can result in the . . . behavior recognized as the symptoms of BPD: impulsive aggression, lack of affective control, and a profound mistrust born out of early disruption in the development of emotional attachment.8 Obviously, psychological theories for BPD

Functional magnetic resonance imaging studies show that areas of the brain controlling emotion and cognition light up in response to food stimuli. Areas of the prefrontal cortex involved with restraint show decreased activity. In other words, it is harder for people who have lost weight to resist food. 15 This has nothing whatsoever to do with a lack of willpower or any kind of moral failure. It’s a normal hormonal fact of life. We feel hungry, cold, tired and depressed. These are all real, measurable physical effects of calorie restriction.

Setting Goals to Increase Dopamine. People are often at their best when working toward a long-term, meaningful goal that they believe is achievable, like earning a degree or getting a promotion. That’s because not only is dopamine released when you finally achieve a long-term goal but it’s also released with each step you make as you move closer to achieving it. Having a goal also allows the prefrontal cortex to more effectively organize your actions. And most importantly, achieving the goal is often less important to happiness than setting the goal in the first place.

The beauty of exercise is that it attacks the problem from both directions at the same time. It gets us moving, naturally, which stimulates the brain stem and gives us more energy, passion, interest, and motivation. We feel more vigorous. From above, in the prefrontal cortex, exercise shifts our self-concept by adjusting all the chemicals I’ve mentioned, including serotonin, dopamine, norepinephrine, BDNF, VEGF, and so on. And unlike many antidepressants, exercise doesn’t selectively influence anything—it adjusts the chemistry of the entire brain to restore normal signaling.

The result is that while teenagers can make decisions that are just as mature, reasoned, and rational as adults’ decisions in normal circumstances, their judgment can be fairly awful when they are feeling intense emotions or stress, conditions that psychologists call hot cognition. In those situations, teens are more likely to make decisions with the limbic system rather than the prefrontal cortex. The presence of peers is one of the things that raises the emotional stakes, making it more likely that teens will seek out risk and short-term reward without pausing to consider the consequences.

Positive relationships keep our safety-threat detection system in check. There is a reason that collectivist cultures focus on relationships. The brain is wired to scan continuously for social and physical threats, except when we are in positive relationships. The oxytocin positive relationships trigger helps the amygdala stay calm so the prefrontal cortex can focus on higher order thinking and learning. Just as you want to identify and remove things that create an emotionally unsafe environment, you have to also focus on building positive relationships that students recognize based on their cultural schema.

The very last part of the brain to get myelinated is the prefrontal cortex—the part of the brain responsible for reason, planning, and deliberation. So while teenage emotions have gone into hyperdrive, reason and logic are still obeying the speed limit. The result is that while teenagers can make decisions that are just as mature, reasoned, and rational as adults’ decisions in normal circumstances, their judgment can be fairly awful when they are feeling intense emotions or stress, conditions that psychologists call hot cognition. In those situations, teens are more likely to make decisions with the limbic system rather than the prefrontal cortex.

I realize it’s not true that I’m no longer shy; I’ve just learned to talk myself down from the ledge (thank you, prefrontal cortex!). By now I do it so automatically that I’m hardly aware it’s happening. When I talk with a stranger or a group of people, my smile is bright and my manner direct, but there’s a split second that feels like I’m stepping onto a high wire. By now I’ve had so many thousands of social experiences that I’ve learned that the high wire is a figment of my imagination, or that I won’t die if I fall. I reassure myself so instantaneously that I’m barely aware I’m doing it. But the reassurance process is still happening— and occasionally it doesn’t work.

But Berns’s study also shed light on exactly why we’re such conformists. When the volunteers played alone, the brain scans showed activity in a network of brain regions including the occipital cortex and parietal cortex, which are associated with visual and spatial perception, and in the frontal cortex, which is associated with conscious decision-making. But when they went along with their group’s wrong answer, their brain activity revealed something very different. Remember, what Asch wanted to know was whether people conformed despite knowing that the group was wrong, or whether their perceptions had been altered by the group. If the former was true, Berns and his team reasoned, then they should see more brain activity in the decision-making prefrontal cortex. That is, the brain scans would pick up the volunteers deciding consciously to abandon their own beliefs to fit in with the group. But if the brain scans showed heightened activity in regions associated with visual and spatial perception, this would suggest that the group had somehow managed to change the individual’s perceptions. That was exactly what happened—the conformists showed less brain activity in the frontal, decision-making regions and more in the areas of the brain associated with perception. Peer pressure, in other words, is not only unpleasant, but can actually change your view of a problem.

The prefrontal cortex is a convergence zone. It receives connections from various specialized systems (like the visual and auditory sensory systems), enabling it to be aware of what's going on in the outside world and to integrate the information it gathers. It also receives connections from the hippocampus and other cortical areas involved in long-term explicit memory, allowing it to retrieve stored information (facts, personal experiences, schemata) relevant to the task at hand. In addition, it sends connections to areas involved in movement control (including movement-control areas in the frontal cortex as well as in subcortical regions), allowing executive decisions to be turned into voluntary actions.

If [t]he mind is a system with many parts, then an innate desire is just one component among others. Some faculties may endow us with greed or lust or malice, but others may endow us with sympathy, foresight, selfrespect, a desire for respect from others, and an ability to learn from our own experiences and those of our neighbors. These are physical circuits residing in the prefrontal cortex and other parts of the brain, not occult powers of a poltergeist, and they have a genetic basis and an evolutionary history no less than the primal urges. It is only the Blank Slate and the Ghost in the Machine that make people think that drives are “biological” but that thinking and decision making are something else.

The amygdala: the brain’s fear center Prefrontal cortex: the front part of the brain that regulates cognitive and executive function, including judgment and mood and emotions Hypothalamic-pituitary-adrenal (HPA) axis: initiates the production of cortisol (longer-acting stress hormone) by the adrenal glands Sympatho-adrenomedullary (SAM) axis: initiates the production of adrenaline and noradrenaline (short-acting stress hormones) by the adrenal glands and brain Hippocampus: processes emotional information, critical for consolidating memories Noradrenergic nucleus in the locus coeruleus: the within-the-brain stress-response system that regulates mood, irritability, locomotion, arousal, attention, and the startle response

The mindfulness definition of an addiction is a SELF-INJURIOUS IMPULSE DISORDER. The mindfulness-based treatment teaches us that we can become AWARE of these self-injurious impulses and learn that they are coming from a really small part of our brain: our AMYGDALA, which is smaller in size than an acorn. We can learn that it is this part of the brain that presses us to self-injure and disregard the consequences. While the amygdala is inside us; it does not truly represent us. We also learn to be AWARE that it is our much larger, grapefruit sized, PREFRONTAL CORTEX, which is the home of our self-caring and self-protective impulses. Our prefrontal cortex is our true representative and the home of authentic "I". The mission of MINDFULNESS is to help us learn how to get our PREFRONTAL CORTEX to become LARGE AND IN CHARGE!

Moreover, sleep deprivation starts to starve the brain. There is a reason why we start to eat comfort food—doughnuts, candy—when we’re tired: our brains crave sugar. After twenty-four hours of sleep deprivation, there is an overall reduction of 6 percent in glucose reaching the brain.9 But the loss isn’t shared equally; the parietal lobe and the prefrontal cortex lose 12 to 14 percent of their glucose. And those are the areas we need most for thinking: for distinguishing between ideas, for social control, and to be able to tell the difference between good and bad.10 To Charles Czeisler, professor of sleep medicine at Harvard Medical School, encouraging a culture of sleepless machismo is downright dangerous.11 He’s amazed by today’s work cultures that glorify sleeplessness, the way the age of Mad Men once glorified people who could hold their drink.

Much of my research had stated that people with PTSD had shrunken prefrontal cortices—that experiencing triggers often shut down the logical centers of our brains and left us irrational and incapable of complex thought. But Siegle told me he’d discovered that research to be flawed. He’d found that with many people with complex PTSD, the exact opposite was happening. In moments of intense stress and trauma, our prefrontal cortices were actually far more active. Normally, if you’re facing a threat, your body immediately reacts to it. Your heart starts pumping blood. The hair on the back of your neck stands up. This is all in service of getting blood to your legs so you can run the hell away from it. On top of this, you feel your heart beating faster. You recognize that you’re freaking out. That makes you even more anxious, and your heart beats even faster. But Siegle told me, “As far as we can tell with complex PTSD, in really stressful situations, you’ve got this coping skill that allows the prefrontal cortex to just shut off some of our evolutionary freak-out mechanisms and instead have high levels of prefrontal activity. So our bodies stop reacting.” In other words, in some moments of intense stress, we are super-duper good at dissociation. Our hearts don’t pump as hard. Our brains cut themselves off from our bodies, so we don’t really have that feedback loop of getting anxious about getting anxious. Instead, our prefrontal cortices blink online—we become hyperrational. Super focused. Calm. Siegle explained it this way: “If running away has never been an option for you, you have to be cunning and do other things. So it’s like, this is time to bring all of our resources online, because we’re going to survive this.

Stress physiologists have found a biological explanation for this phenomenon as well. The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school. When you’re overwhelmed by uncontrollable impulses and distracted by negative feelings, it’s hard to learn the alphabet. And in fact, when kindergarten teachers are surveyed about their students, they say that the biggest problem they face is not children who don’t know their letters and numbers; it is kids who don’t know how to manage their tempers or calm themselves down after a provocation.

I think of sensitivity within ADHD as having two parts. First, there is a deep curiosity about and sensitivity to new information and stimuli, an experience not too different from that of a bee driven to discover all available pollen. Second, there is the sensitivity that results from being ADHD, especially if it’s been unknown, where people become sensitive to criticism and being judged. It’s hard to do well at some times and then at other times feel like a total failure—for being late, missing an appointment, missing a deadline, getting dates or times confused, or other results of having a challenged prefrontal cortex and struggling executive functioning. There is also a sensitivity to ourselves—our own emotions, regulating those emotions, and not being so hard on ourselves. It’s no surprise, then, that it is not uncommon for adults with ADHD to have meltdowns or “blowups”—like an adult tantrum.

What’s more, AI researchers have begun to realize that emotions may be a key to consciousness. Neuroscientists like Dr. Antonio Damasio have found that when the link between the prefrontal lobe (which governs rational thought) and the emotional centers (e.g., the limbic system) is damaged, patients cannot make value judgments. They are paralyzed when making the simplest of decisions (what things to buy, when to set an appointment, which color pen to use) because everything has the same value to them. Hence, emotions are not a luxury; they are absolutely essential, and without them a robot will have difficulty determining what is important and what is not. So emotions, instead of being peripheral to the progress of artificial intelligence, are now assuming central importance. If a robot encounters a raging fire, it might rescue the computer files first, not the people, since its programming might say that valuable documents cannot be replaced but workers always can be. It is crucial that robots be programmed to distinguish between what is important and what is not, and emotions are shortcuts the brain uses to rapidly determine this. Robots would thus have to be programmed to have a value system—that human life is more important than material objects, that children should be rescued first in an emergency, that objects with a higher price are more valuable than objects with a lower price, etc. Since robots do not come equipped with values, a huge list of value judgments must be uploaded into them. The problem with emotions, however, is that they are sometimes irrational, while robots are mathematically precise. So silicon consciousness may differ from human consciousness in key ways. For example, humans have little control over emotions, since they happen so rapidly and because they originate in the limbic system, not the prefrontal cortex of the brain. Furthermore, our emotions are often biased.

The prefrontal cortex is a complex, fragile region of the brain. In its healthy state, it directs human impulses toward rational choices and away from destructive or self destructive behavior. It allows us to deal with the present moment while storing plans for the future. Yet as the newest part of the brain to develop in human evolution, the prefrontal cortex is also the region that takes the longest time to reach maturity, or maximum operating efficiency. It will not be fully functional until the person is past the age of twenty. This out of sync progress ranks among the most profound natural misfortunes of humanity. For while the prefrontal cortex is taking its time, other powerful components of the humaninprogress have raced across the finish line and function without the cortex's restraints. A young adult with a still developing prefrontal cortex will have reached .physical maturity, which of course means the capacity to reproduce and the strong hormonal drive to do so.

Then there are the metabolic costs of switching itself that I wrote about earlier. Asking the brain to shift attention from one activity to another causes the prefrontal cortex and striatum to burn up oxygenated glucose, the same fuel they need to stay on task. And the kind of rapid, continual shifting we do with multitasking causes the brain to burn through fuel so quickly that we feel exhausted and disoriented after even a short time. We’ve literally depleted the nutrients in our brain. This leads to compromises in both cognitive and physical performance. Among other things, repeated task switching leads to anxiety, which raises levels of the stress hormone cortisol in the brain, which in turn can lead to aggressive and impulsive behaviors. By contrast, staying on task is controlled by the anterior cingulate and the striatum, and once we engage the central executive mode, staying in that state uses less energy than multitasking and actually reduces the brain’s need for glucose.

The speediest and most reliable way to strengthen the prefrontal cortex, and begin to recover the resilience of our true self, is through experiences with people who can be, as the clinical psychologist Diana Fosha puts it, true others to our true self. True others are those who can see and reflect our true self back to us when we have forgotten, or perhaps have never known, who we truly are. They remember our best self when we are mired in our worst self and accept without judgment all of who we are. True others are not necessarily the people closest to us, though they may be: they are the people most attuned to us, those most accepting of our innate goodness, our essential worth as human beings. For many people, a true other can be a spiritual figure or deity; for others, it may be a counselor, teacher, or friend. When someone who is acting as a true other genuinely sees us at our best, we can see ourselves in that light, too. This mirroring helps us rediscover our resilient self.

Reflecting on the Myanmar tragedy, Pwint Htun wrote to me in July 2023, “I naively used to believe that social media could elevate human consciousness and spread the perspective of common humanity through interconnected pre-frontal cortexes in billions of human beings. What I realize is that the social media companies are not incentivized to interconnect pre-frontal cortexes. Social media companies are incentivized to create interconnected limbic systems—which is much more dangerous for humanity.

According to a recent study of the brains of identical and fraternal twins, differences in the amount of gray matter in the frontal lobes are not only genetically influenced but are significantly correlated with differences in intelligence.37 A study of Albert Einstein’s brain revealed that he had large, unusually shaped inferior parietal lobules, which participate in spatial reasoning and intuitions about number.38 Gay men are likely to have a smaller third interstitial nucleus in the anterior hypothalamus, a nucleus known to have a role in sex differences.39 And convicted murderers and other violent, antisocial people are likely to have a smaller and less active prefrontal cortex, the part of the brain that governs decision making and inhibits impulses.40 These gross features of the brain are almost certainly not sculpted by information coming in from the senses, which implies that differences in intelligence, scientific genius, sexual orientation, and impulsive violence are not entirely learned.

Take, for example, the following sentence: “I prefer to eat with a fork and a camel.” Your brain has just generated an N400 wave, an error signal evoked by a word or an image which is incompatible with the preceding context.11 As its name suggests, this is a negative response that occurs at about four hundred milliseconds after the anomaly and arises from neuronal populations of the left temporal cortex that are sensitive to word meaning. On the other hand, Broca’s area in the inferior prefrontal cortex reacts to errors of syntax, when the brain predicts a certain category of word and receives another,12 as in the following sentence: “Don’t hesitate to take your whenever medication you feel sick.” This time, just after the unexpected word “whenever,” the areas of your brain that specialize in syntax emitted a negative wave immediately followed by a P600 wave—a positive peak that occurs around six hundred milliseconds. This response indicates that your brain detected a grammar error and is trying to repair it.

The brain makes up l/50th of our body mass but consumes a staggering 1/5th of the calories we burn for energy. If your brain were a car, in terms of gas mileage, it’d be a Hummer. Most of our conscious activity is happening in our prefrontal cortex, the part of our brain responsible for focus, handling short-term memory, solving problems, and moderating impulse control. It’s at the heart of what makes us human and the center for our executive control and willpower. The “last in, first out” theory is very much at work inside our head. The most recent parts of our brain to develop are the first to suffer if there is a shortage of resources. Older, more developed areas of the brain, such as those that regulate breathing and our nervous responses, get first helpings from our blood stream and are virtually unaffected if we decide to skip a meal. The prefrontal cortex, on the other hand, feels the impact. Unfortunately, being relatively young in terms of human development, it’s the runt of the litter come feeding time.

A recent comparative study looked at the neuropil volume in different areas of humans’ and chimps’ brains.43 Neuropil comprises the brain areas that are made of connections: a mixture of axons, dendrites, synapses, and more. The prefrontal cortex—the brain area in humans involved in decision making, problem solving, mental state attribution, and temporal planning—has a greater percentage of neuropil than is found in chimp brains, and the dendrites in this region have more spines with which they connect to other neurons than do other parts of the brain. This anatomical finding suggests that the connectivity patterns of the prefrontal neurons may contribute to what is different about our brains. Interestingly, corvids have a relatively larger forebrain than most other birds, especially the areas that are thought to be analogous to the prefrontal cortex of mammals.44 Yet, as we shall see, while this way of thinking may explain increased abilities, it is not going to get us to the goal of understanding how consciousness is enabled.

Philosophers and many proponents of cognitive psychology hold that moral judgments are within our control, and thus people who choose to commit crimes, barring delusions, know what they are doing and that it is wrong. The legal system depends on this notion. However, recent research suggests that damage to an area of the brain just behind the eyes can transform the way people make moral decisions. The results indicate that the ventromedial prefrontal cortex, implicated in the feeling of compassion, may be the foundation for moral regulations, assisting us in inhibiting (or not) harmful treatment of others. Failure in its development, or damage to it, might alter the way a person perceives the moral landscape, which will thus affect his or her actions. If juries include information of this kind in their deliberations, it could mitigate the harshness of the sentences they impose on convicted criminals. While more research must be done, other types of brain scans are being entered as evidence in the trials of some heinous crimes to show that the perpetrator could not help what he did.

But what separates human consciousness from the consciousness of animals? Humans are alone in the animal kingdom in understanding the concept of tomorrow. Unlike animals, we constantly ask ourselves “What if?” weeks, months, and even years into the future, so I believe that Level III consciousness creates a model of its place in the world and then simulates it into the future, by making rough predictions. We can summarize this as follows: Human consciousness is a specific form of consciousness that creates a model of the world and then simulates it in time, by evaluating the past to simulate the future. This requires mediating and evaluating many feedback loops in order to make a decision to achieve a goal. By the time we reach Level III consciousness, there are so many feedback loops that we need a CEO to sift through them in order to simulate the future and make a final decision. Accordingly, our brains differ from those of other animals, especially in the expanded prefrontal cortex, located just behind the forehead, which allows us to “see” into the future. Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest achievement of the human brain is its ability to imagine objects and episodes that do not exist in the realm of the real, and it is this ability that allows us to think about the future. As one philosopher noted, the human brain is an ‘anticipation machine,’ and ‘making the future’ is the most important thing it does.” Using brain scans, we can even propose a candidate for the precise area of the brain where simulation of the future takes place. Neurologist Michael Gazzaniga notes that “area 10 (the internal granular layer IV), in the lateral prefrontal cortex, is almost twice as large in humans as in apes. Area 10 is involved with memory and planning, cognitive flexibility, abstract thinking, initiating appropriate behavior, and inhibiting inappropriate behavior, learning rules, and picking out relevant information from what is perceived through the senses.” (For this book, we will refer to this area, in which decision making is concentrated, as the dorsolateral prefrontal cortex, although there is some overlap with other areas of the brain.)

Altogether, these observations suggest that several processes contribute to psychotic experience: the loss of familiarity with the world, hypothetically associated with noisy information processing; increased novelty detection mediated by the hippocampus; associated alterations of prefrontal cortical processing, which have reliably been associated with impairments in working memory and other executive functions; increased top-down effects of prior beliefs mediated by the frontal cortex that may reflect compensatory efforts to cope with an increasingly complex and unfamiliar world; and finally disinhibition of subcortical dopaminergic neurotransmission, which increases salience attribution to otherwise irrelevant stimuli. Furthermore, increased noise of chaotic or stress-dependent dopamine firing can reduce the encoding of errors of reward prediction elicited by primary and secondary reinforcers, thus contributing to a subjective focusing of attention on apparently novel and mysterious environmental cues while reducing attention and motivation elicited by common and natural and social stimuli.

Take the common Buddhist practice of “noting,” for example: practitioners learn to label their worries and feelings with a simple tag like “thinking” or “anger,” taking note of them mindfully without engaging them directly. In a 2007 study, the UCLA psychologist Matthew Lieberman showed thirty volunteers fear-provoking images and then asked them to note their feelings (“I feel afraid”) as he monitored their brain activity. Upon seeing the unpleasant images, the subjects’ amygdalae lit up at first, but the labeling process soon sparked activity in the right ventrolateral prefrontal cortex, damping activity in the amygdala. Lieberman believes this mindful noting—the simple act of putting our feelings into words—helps the brain disambiguate our emotions and provide a level of detachment from them. “One of the ways labeling is useful is in talking with other people,” he told me. “If you can get someone to talk about their feelings, it’ll end up being beneficial to them in ways they may not realize.” (Writing about how we feel in a journal serves the same purpose; it helps us sort out emotions, like anxiety, on a deeper subconscious level.)

An unexpected breakup can cause considerable psychological distress. The social pain has been associated with a twentyfold higher risk of developing depression in the coming year. It's important to lean on family and friends for support. You'll find that brain activity in the craving centers will have decreased significantly after about ten weeks." "Actually, it's been almost two weeks and I don't think of him at all," Layla offered. "Then you weren't truly emotionally invested in that relationship," Charu Auntie said. "Or you're a psychopath." "Definitely a psychopath." Daisy sliced furiously, decimating the onion as tears poured down her cheeks. "She didn't feel anything when she stole the pakoras from my lunch kit in sixth grade." Charu Auntie balanced the basket on one hip and adjusted her glasses. "Distraction and self-care are important to prevent a craving response in the ventral tegmental area, the nucleus accumbens, and orbitofrontrontal/prefrontal cortex." "I think she's saying, in her oddly complicated way, that she thinks you should hook up with fuckboy Danny," Daisy said. "Too bad the sexy beast upstairs is such a piece of-" "Shhh.

The most obvious way that defensive motivational states make themselves known to us is, in fact, through our own behavior. The ability to observe one’s behavior and thus create representations of behavior in working memory is called monitoring.77 By directing our attention to our behavioral output, we can acquire information about what we are doing and intentionally adjust our behavior in light of thoughts, memories, and feelings. As an executive function of working memory, monitoring, not surprisingly, involves circuits in the prefrontal cortex.78 We use observations of our own behavior to regulate how we act in social situations.79 If you become aware that your behavior is negatively affecting others, you can make adjustments as a social situation evolves. Or if you notice you are acting in a biased way toward some group, you can make corrections. In addition, through monitoring one can observe undesirable habits and seek to change these through therapy or other means. Not everyone is equally adept at using monitoring to improve self-awareness. The field of emotional intelligence is all about how people differ in such abilities and how one can be trained to do better.80

There is real neurological evidence for the power of spiritual reflection to make us aware of our sin. Christians actually use a different part of their brain to self-evaluate than non-Christians. In a study conducted in Beijing, researchers compared which part of the brain people used to evaluate both themselves and others. The study is summarized in an article with the snappy title, “Neural Consequences of Religious Belief on Self-Referential Processing.” Non-religious subjects used one part of the brain (the ventral medial prefrontal cortex, in case you’re interested) to evaluate themselves, but another part (the dorsal medial prefrontal cortex) to evaluate others. Christians used the same part of the brain to evaluate themselves that they used to evaluate others. Researchers hypothesized this is because they were actually using a kind of “Jesus reference point” for self-evaluation; they were really asking, “What does God think of me?” UCLA researcher Jeff Schwartz said that this study is one of the most important scientific papers published in the last decade. Prayer, meditation, and confession actually have the power to rewire the brain in a way that can make us less self-referential and more aware of how God sees us. But

For centuries, Eastern religions have been telling us that it’s our egos that trap us in suffering. In the 5th century, Indian adept Vasubandu wrote, “So long as you grasp at the self, you stay bound to the world of suffering.” These spiritual traditions emphasize meditation, contemplation, altruistic service, and compassion as ways to escape the ego. Our emotions and thoughts become less “sticky” and “I, me, mine” “lose their self-hypnotic power.” That’s how we stop selfing. Once we drop our identification with the ego-self enshrined in the prefrontal cortex and enter Bliss Brain, we make the subject-object shift. We can ask ourselves, “If I’m not my thoughts, and I’m the one thinking those thoughts, then who might I be?” This perspective takes us out of selfing and into the present moment. In the meditative present, we can connect with the great nonlocal field of consciousness. Different traditions have different names for it: the Tao, the Anima Mundi, the Universal Mind, God, the All That Is. We then see our local self as the object. With this view from the mountaintop, we’re able to perceive new possibilities of what we might become, this time from the perspective of oneness with the universe. Free of the drag of the ego, uncoupled from the chatter of the demon, the conditioned personalities we inherited from our history and past experiences no longer confine our sense of self.

To give you a sense of the sheer volume of unprocessed information that comes up the spinal cord into the thalamus, let’s consider just one aspect: vision, since many of our memories are encoded this way. There are roughly 130 million cells in the eye’s retina, called cones and rods; they process and record 100 million bits of information from the landscape at any time. This vast amount of data is then collected and sent down the optic nerve, which transports 9 million bits of information per second, and on to the thalamus. From there, the information reaches the occipital lobe, at the very back of the brain. This visual cortex, in turn, begins the arduous process of analyzing this mountain of data. The visual cortex consists of several patches at the back of the brain, each of which is designed for a specific task. They are labeled V1 to V8. Remarkably, the area called V1 is like a screen; it actually creates a pattern on the back of your brain very similar in shape and form to the original image. This image bears a striking resemblance to the original, except that the very center of your eye, the fovea, occupies a much larger area in V1 (since the fovea has the highest concentration of neurons). The image cast on V1 is therefore not a perfect replica of the landscape but is distorted, with the central region of the image taking up most of the space. Besides V1, other areas of the occipital lobe process different aspects of the image, including: •  Stereo vision. These neurons compare the images coming in from each eye. This is done in area V2. •  Distance. These neurons calculate the distance to an object, using shadows and other information from both eyes. This is done in area V3. •  Colors are processed in area V4. •  Motion. Different circuits can pick out different classes of motion, including straight-line, spiral, and expanding motion. This is done in area V5. More than thirty different neural circuits involved with vision have been identified, but there are probably many more. From the occipital lobe, the information is sent to the prefrontal cortex, where you finally “see” the image and form your short-term memory. The information is then sent to the hippocampus, which processes it and stores it for up to twenty-four hours. The memory is then chopped up and scattered among the various cortices. The point here is that vision, which we think happens effortlessly, requires billions of neurons firing in sequence, transmitting millions of bits of information per second. And remember that we have signals from five sense organs, plus emotions associated with each image. All this information is processed by the hippocampus to create a simple memory of an image. At present, no machine can match the sophistication of this process, so replicating it presents an enormous challenge for scientists who want to create an artificial hippocampus for the human brain.

In a nutshell, serotonin gives your neurons a thick skin, so they can withstand the pace of the bristling, bustling, neural metropolis. And then along comes a tiny army of LSD molecules, marching out of their Trojan Horse—a small purple tablet—and they look just like serotonin molecules. If you were a receptor site, you wouldn’t be able to tell the difference. Through this insidious trickery, LSD molecules fool the receptors that normally suck up serotonin. They elbow serotonin out of the way and lodge themselves in these receptors instead. They do this in perceptual regions of the cortex, such as the occipital and temporal lobes, in charge of seeing and hearing, and in more cognitive zones, such as the prefrontal cortex, where conscious judgments take place. They do it in brain-stem nuclei that send their messages throughout the brain and body, felt as arousal and alertness. And once they’ve taken up their positions, Troy begins to fall. Not through force, as with the devastating blows of alcohol and dextromethorphan, but through passivity. Once encamped in their serotonin receptors, LSD molecules simply remain passive. They don’t inhibit, they don’t soothe, they don’t regulate, or filter, or modulate. They sit back with evil little grins and say, “It’s showtime! You just go ahead and fire as much as you like. You’re going to pick up a lot of channels you never got before. So have fun. And call me in about eight hours when my shift is over.

Making matters worse, the prefrontal cortex, the part of the brain that governs so much of our higher executive function—the ability to plan and to reason, the ability to control impulses and to self-reflect—is still undergoing crucial structural changes during adolescence and continues to do so until human beings are in their mid- or even late twenties. This is not to say that teenagers lack the tools to reason. Just before puberty, the prefrontal cortex undergoes a huge flurry of activity, enabling kids to better grasp abstractions and understand other points of view. (In Darling’s estimation, these new capabilities are why adolescents seem so fond of arguing—they can actually do it, and not half-badly, for the first time.) But their prefrontal cortexes are still adding myelin, the fatty white substance that speeds up neural transmissions and improves neural connections, which means that adolescents still can’t grasp long-term consequences or think through complicated choices like adults can. Their prefrontal cortexes are also still forming and consolidating connections with the more primitive, emotional parts of the brain—known collectively as the limbic system—which means that adolescents don’t yet have the level of self-control that adults do. And they lack wisdom and experience, which means they often spend a lot of time passionately arguing on behalf of ideas that more seasoned adults find inane. “They’re kind of flying by the seat of their pants,” says Casey. “If they’ve had only one experience that’s pretty intense, but they haven’t had any other experiences in this domain, it’s going to drive their behavior.

Brain imaging studies suggest that a couple brain areas in particular are involved in cognitive control: the anterior cingulate cortex (ACC) and the lateral prefrontal cortex (lateral PFC). We’ll be referring to these together as the “cognitive control regions” of the brain. There is still some debate about the precise role played by each of these regions, but one plausible characterization is that the ACC is a kind of smoke detector, and the lateral PFC is the fire response team. Like a smoke detector, the ACC is in constant monitoring mode, waiting to detect a whiff of danger, such as an instance of cognitive conflict. In the case of the Stroop task, we’ve got two automatic processes that are in conflict: the identification of a typeface or color versus the automatic processing of a simple word (assuming you’re literate and it’s your native language). This conflict alerts the ACC, which then sends out an alarm to the lateral PFC to come deal with the situation. The lateral PFC is responsible for many higher cognitive functions, such as the integration of conscious and unconscious knowledge, working memory (the small spotlight of consciousness that allows us to focus on explicit information), and conscious planning. Most relevantly, when it comes to the case of the Stroop task, the lateral PFC also exerts control over other areas of the brain by strengthening the activation of task-relevant networks at the expense of other networks. By weakening certain neural pathways, the lateral PFC essentially tells them to stop doing what they are doing, which is the neural equivalent of fire-retarding foam. In the Stroop task presented above,

There are, in fact, some people who do not appear to have a built-in preference for their own race. They suffer from something called Williams Syndrome, and lack the usual fear of strangers and the unknown. Researchers at the Central Institute of Mental health in Mannheim, Germany, found that normal white children, aged five to seven, matched good characteristics with photographs of people of their own race and negative characteristics with people of other races. Twenty children with Williams Syndrome did not, matching characteristics without regard to race. The syndrome appears to change the way the amygdalae communicate with the pre-frontal cortex, and it eliminates social inhibition. People with Williams Syndrome are “hypersocial,” and do not see danger in the faces of people who may be threats. They also tend to be mildly retarded and to suffer from other physical complications.

Given this new theory of mental illness, we can now apply it to various forms of mental disorders, summarizing the previous discussion in this new light. We saw earlier that the obsessive behavior of people suffering from OCD might arise when the checks and balances between several feedback loops are thrown out of balance: one registering something as amiss, another carrying out corrective action, and another one signaling that the matter has been taken care of. The failure of the checks and balances within this loop can cause the brain to be locked into a vicious cycle, so the mind never believes that the problem has been resolved. The voices heard by schizophrenics might arise when several feedback loops are no longer balancing one another. One feedback loop generates spurious voices in the temporal cortex (i.e., the brain is talking to itself). Auditory and visual hallucinations are often checked by the anterior cingulate cortex, so a normal person can differentiate between real and fictitious voices. But if this region of the brain is not working properly, the brain is flooded with disembodied voices that it believes are real. This can cause schizophrenic behavior. Similarly, the manic-depressive swings of someone with bipolar disorder might be traced to an imbalance between the left and right hemispheres. The necessary interplay between optimistic and pessimistic assessments is thrown off balance, and the person oscillates wildly between these two diverging moods. Paranoia may also be viewed in this light. It results from an imbalance between the amygdala (which registers fear and exaggerates threats) and the prefrontal cortex, which evaluates these threats and puts them into perspective. We should also stress that evolution has given us these feedback loops for a reason: to protect us. They keep us clean, healthy, and socially connected. The problem occurs when the dynamic between opposing feedback loops is disrupted.

Educated people, of course, know that perception, cognition, language, and emotion are rooted in the brain. But it is still tempting to think of the brain as it was shown in old educational cartoons, as a control panel with gauges and levers operated by a user — the self, the soul, the ghost, the person, the “me.” But cognitive neuroscience is showing that the self, too, is just another network of brain systems. [C]ognitive neuroscientists have not only exorcised the ghost but have shown that the brain does not even have a part that does exactly what the ghost is supposed to do: review all the facts and make a decision for the rest of the brain to carry out. Each of us feels that there is a single “I” in control. But that is an illusion that the brain works hard to produce, like the impression that our visual fields are rich in detail from edge to edge. The brain does have supervisory systems in the prefrontal lobes and anterior cingulate cortex, which can push the buttons of behavior and override habits and urges. But those systems are gadgets with specific quirks and limitations; they are not implementations of the rational free agent traditionally identified with the soul or the self.

While the visual areas of the brain are active, other areas involved with smell, taste, and touch are largely shut down. Almost all the images and sensations processed by the body are self-generated, originating from the electromagnetic vibrations from our brain stem, not from external stimuli. The body is largely isolated from the outside world. Also, when we dream, we are more or less paralyzed. (Perhaps this paralysis is to prevent us from physically acting out our dreams, which could be disastrous. About 6 percent of people suffer from “sleep paralysis” disorder, in which they wake up from a dream still paralyzed. Often these individuals wake up frightened and believing that there are creatures pinning down their chest, arms, and legs. There are paintings from the Victorian era of women waking up with a terrifying goblin sitting on their chest glaring down at them. Some psychologists believe that sleep paralysis could explain the origin of the alien abduction syndrome.) The hippocampus is active when we dream, suggesting that dreams draw upon our storehouse of memories. The amygdala and anterior cingulate are also active, meaning that dreams can be highly emotional, often involving fear. But more revealing are the areas of the brain that are shut down, including the dorsolateral prefrontal cortex (which is the command center of the brain), the orbitofrontal cortex (which can act like a censor or fact-checker), and the temporoparietal region (which processes sensory motor signals and spatial awareness). When the dorsolateral prefrontal cortex is shut down, we can’t count on the rational, planning center of the brain. Instead, we drift aimlessly in our dreams, with the visual center giving us images without rational control. The orbitofrontal cortex, or the fact-checker, is also inactive. Hence dreams are allowed to blissfully evolve without any constraints from the laws of physics or common sense. And the temporoparietal lobe, which helps coordinate our sense of where we are located using signals from our eyes and inner ear, is also shut down, which may explain our out-of-body experiences while we dream. As we have emphasized, human consciousness mainly represents the brain constantly creating models of the outside world and simulating them into the future. If so, then dreams represent an alternate way in which the future is simulated, one in which the laws of nature and social interactions are temporarily suspended

A different approach was taken in 1972 by Dr. Walter Mischel, also of Stanford, who analyzed yet another characteristic among children: the ability to delay gratification. He pioneered the use of the “marshmallow test,” that is, would children prefer one marshmallow now, or the prospect of two marsh-mallows twenty minutes later? Six hundred children, aged four to six, participated in this experiment. When Mischel revisited the participants in 1988, he found that those who could delay gratification were more competent than those who could not. In 1990, another study showed a direct correlation between those who could delay gratification and SAT scores. And a study done in 2011 indicated that this characteristic continued throughout a person’s life. The results of these and other studies were eye-opening. The children who exhibited delayed gratification scored higher on almost every measure of success in life: higher-paying jobs, lower rates of drug addiction, higher test scores, higher educational attainment, better social integration, etc. But what was most intriguing was that brain scans of these individuals revealed a definite pattern. They showed a distinct difference in the way the prefrontal cortex interacted with the ventral striatum, a region involved in addiction. (This is not surprising, since the ventral striatum contains the nucleus accumbens, known as the “pleasure center.” So there seems to be a struggle here between the pleasure-seeking part of the brain and the rational part to control temptation, as we saw in Chapter 2.) This difference was no fluke. The result has been tested by many independent groups over the years, with nearly identical results. Other studies have also verified the difference in the frontal-striatal circuitry of the brain, which appears to govern delayed gratification. It seems that the one characteristic most closely correlated with success in life, which has persisted over the decades, is the ability to delay gratification. Although this is a gross simplification, what these brain scans show is that the connection between the prefrontal and parietal lobes seems to be important for mathematical and abstract thought, while the connection between the prefrontal and limbic system (involving the conscious control of our emotions and pleasure center) seems to be essential for success in life. Dr. Richard Davidson, a neuroscientist at the University of Wisconsin–Madison, concludes, “Your grades in school, your scores on the SAT, mean less for life success than your capacity to co-operate, your ability to regulate your emotions, your capacity to delay your gratification, and your capacity to focus your attention. Those skills are far more important—all the data indicate—for life success than your IQ or your grades.

WHY ADDICTION IS NOT A DISEASE In its present-day form, the disease model of addiction asserts that addiction is a chronic, relapsing brain disease. This disease is evidenced by changes in the brain, especially alterations in the striatum, brought about by the repeated uptake of dopamine in response to drugs and other substances. But it’s also shown by changes in the prefrontal cortex, where regions responsible for cognitive control become partially disconnected from the striatum and sometimes lose a portion of their synapses as the addiction progresses. These are big changes. They can’t be brushed aside. And the disease model is the only coherent model of addiction that actually pays attention to the brain changes reported by hundreds of labs in thousands of scientific articles. It certainly explains the neurobiology of addiction better than the “choice” model and other contenders. It may also have some real clinical utility. It makes sense of the helplessness addicts feel and encourages them to expiate their guilt and shame, by validating their belief that they are unable to get better by themselves. And it seems to account for the incredible persistence of addiction, its proneness to relapse. It even demonstrates why “choice” cannot be the whole answer, because choice is governed by motivation, which is governed by dopamine, and the dopamine system is presumably diseased. Then why should we reject the disease model? The main reason is this: Every experience that is repeated enough times because of its motivational appeal will change the wiring of the striatum (and related regions) while adjusting the flow and uptake of dopamine. Yet we wouldn’t want to call the excitement we feel when visiting Paris, meeting a lover, or cheering for our favourite team a disease. Each rewarding experience builds its own network of synapses in and around the striatum (and OFC), and those networks continue to draw dopamine from its reservoir in the midbrain. That’s true of Paris, romance, football, and heroin. As we anticipate and live through these experiences, each network of synapses is strengthened and refined, so the uptake of dopamine gets more selective as rewards are identified and habits established. Prefrontal control is not usually studied when it comes to travel arrangements and football, but we know from the laboratory and from real life that attractive goals frequently override self-restraint. We know that ego fatigue and now appeal, both natural processes, reduce coordination between prefrontal control systems and the motivational core of the brain (as I’ve called it). So even though addictive habits can be more deeply entrenched than many other habits, there is no clear dividing line between addiction and the repeated pursuit of other attractive goals, either in experience or in brain function. London just doesn’t do it for you anymore. It’s got to be Paris. Good food, sex, music . . . they no longer turn your crank. But cocaine sure does.

Recently, brain scans of schizophrenics taken while they were having auditory hallucinations have helped explain this ancient disorder. For example, when we silently talk to ourselves, certain parts of the brain light up on an MRI scan, especially in the temporal lobe (such as in Wernicke’s area). When a schizophrenic hears voices, the very same areas of the brain light up. The brain works hard to construct a consistent narrative, so schizophrenics try to make sense of these unauthorized voices, believing they originate from strange sources, such as Martians secretly beaming thoughts into their brains. Dr. Michael Sweeney of Ohio State writes, “Neurons wired for the sensation of sound fire on their own, like gas-soaked rags igniting spontaneously in a hot, dark garage. In the absence of sights and sounds in the surrounding environment, the schizophrenic’s brain creates a powerful illusion of reality.” Notably, these voices seem to be coming from a third party, who often gives the subject commands, which are mostly mundane but sometimes violent. Meanwhile, the simulation centers in the prefrontal cortex seem to be on automatic pilot, so in a way it’s as though the consciousness of a schizophrenic is running the same sort of simulations we all do, except they’re done without his permission. The person is literally talking to himself without his knowledge. HALLUCINATIONS The mind constantly generates hallucinations of its own, but for the most part they are easily controlled. We see images that don’t exist or hear spurious sounds, for example, so the anterior cingulate cortex is vital to distinguish the real from the manufactured. This part of the brain helps us distinguish between stimuli that are external and those that are internally generated by the mind itself. However, in schizophrenics, it is believed that this system is damaged, so that the person cannot distinguish real from imaginary voices. (The anterior cingulate cortex is vital because it lies in a strategic place, between the prefrontal cortex and the limbic system. The link between these two areas is one of the most important in the brain, since one area governs rational thinking, and the other emotions.) Hallucinations, to some extent, can be created on demand. Hallucinations occur naturally if you place someone in a pitch-black room, an isolation chamber, or a creepy environment with strange noises. These are examples of “our eyes playing tricks on us.” Actually, the brain is tricking itself, internally creating false images, trying to make sense of the world and identify threats. This effect is called “pareidolia.” Every time we look at clouds in the sky, we see images of animals, people, or our favorite cartoon characters. We have no choice. It is hardwired into our brains. In a sense, all images we see, both real and virtual, are hallucinations, because the brain is constantly creating false images to “fill in the gaps.” As we’ve seen, even real images are partly manufactured. But in the mentally ill, regions of the brain such as the anterior cingulate cortex are perhaps damaged, so the brain confuses reality and fantasy.

For instance, emotional memories are stored in the amygdala, but words are recorded in the temporal lobe. Meanwhile, colors and other visual information are collected in the occipital lobe, and the sense of touch and movement reside in the parietal lobe. So far, scientists have identified more than twenty categories of memories that are stored in different parts of the brain, including fruits and vegetables, plants, animals, body parts, colors, numbers, letters, nouns, verbs, proper names, faces, facial expressions, and various emotions and sounds. Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the brain stem, to the thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the hippocampus to form long-term memories. (illustration credit 5.1) A single memory—for instance, a walk in the park—involves information that is broken down and stored in various regions of the brain, but reliving just one aspect of the memory (e.g., the smell of freshly cut grass) can suddenly send the brain racing to pull the fragments together to form a cohesive recollection. The ultimate goal of memory research is, then, to figure out how these scattered fragments are somehow reassembled when we recall an experience. This is called the “binding problem,” and a solution could potentially explain many puzzling aspects of memory. For instance, Dr. Antonio Damasio has analyzed stroke patients who are incapable of identifying a single category, even though they are able to recall everything else. This is because the stroke has affected just one particular area of the brain, where that certain category was stored. The binding problem is further complicated because all our memories and experiences are highly personal. Memories might be customized for the individual, so that the categories of memories for one person may not correlate with the categories of memories for another. Wine tasters, for example, may have many categories for labeling subtle variations in taste, while physicists may have other categories for certain equations. Categories, after all, are by-products of experience, and different people may therefore have different categories. One novel solution to the binding problem uses the fact that there are electromagnetic vibrations oscillating across the entire brain at roughly forty cycles per second, which can be picked up by EEG scans. One fragment of memory might vibrate at a very precise frequency and stimulate another fragment of memory stored in a distant part of the brain. Previously it was thought that memories might be stored physically close to one another, but this new theory says that memories are not linked spatially but rather temporally, by vibrating in unison. If this theory holds up, it means that there are electromagnetic vibrations constantly flowing through the entire brain, linking up different regions and thereby re-creating entire memories. Hence the constant flow of information between the hippocampus, the prefrontal cortex, the thalamus, and the different cortices might not be entirely neural after all. Some of this flow may be in the form of resonance across different brain structures.

We are conscious of only a tiny fraction of the information that our brains process in each moment.1 Although we continually notice changes in our experience—in thought, mood, perception, behavior, etc.—we are utterly unaware of the neurophysiological events that produce them. In fact, we can be very poor witnesses to experience itself. By merely glancing at your face or listening to your tone of voice, others are often more aware of your state of mind and motivations than you are. I generally start each day with a cup of coffee or tea—sometimes two. This morning, it was coffee (two). Why not tea? I am in no position to know. I wanted coffee more than I wanted tea today, and I was free to have what I wanted. Did I consciously choose coffee over tea? No. The choice was made for me by events in my brain that I, as the conscious witness of my thoughts and actions, could not inspect or influence. Could I have “changed my mind” and switched to tea before the coffee drinker in me could get his bearings? Yes, but this impulse would also have been the product of unconscious causes. Why didn’t it arise this morning? Why might it arise in the future? I cannot know. The intention to do one thing and not another does not originate in consciousness—rather, it appears in consciousness, as does any thought or impulse that might oppose it. The physiologist Benjamin Libet famously used EEG to show that activity in the brain’s motor cortex can be detected some 300 milliseconds before a person feels that he has decided to move.2 Another lab extended this work using functional magnetic resonance imaging (fMRI): Subjects were asked to press one of two buttons while watching a “clock” composed of a random sequence of letters appearing on a screen. They reported which letter was visible at the moment they decided to press one button or the other. The experimenters found two brain regions that contained information about which button subjects would press a full 7 to 10 seconds before the decision was consciously made.3 More recently, direct recordings from the cortex showed that the activity of merely 256 neurons was sufficient to predict with 80 percent accuracy a person’s decision to move 700 milliseconds before he became aware of it.4 These findings are difficult to reconcile with the sense that we are the conscious authors of our actions. One fact now seems indisputable: Some moments before you are aware of what you will do next—a time in which you subjectively appear to have complete freedom to behave however you please—your brain has already determined what you will do. You then become conscious of this “decision” and believe that you are in the process of making it. The distinction between “higher” and “lower” systems in the brain offers no relief: I, as the conscious witness of my experience, no more initiate events in my prefrontal cortex than I cause my heart to beat. There will always be some delay between the first neurophysiological events that kindle my next conscious thought and the thought itself. And even if there weren’t—even if all mental states were truly coincident with their underlying brain states—I cannot decide what I will next think or intend until a thought or intention arises. What will my next mental state be? I do not know—it just happens. Where is the freedom in that?

Dr. Hobson (with Dr. Robert McCarley) made history by proposing the first serious challenge to Freud’s theory of dreams, called the “activation synthesis theory.” In 1977, they proposed the idea that dreams originate from random neural firings in the brain stem, which travel up to the cortex, which then tries to make sense of these random signals. The key to dreams lies in nodes found in the brain stem, the oldest part of the brain, which squirts out special chemicals, called adrenergics, that keep us alert. As we go to sleep, the brain stem activates another system, the cholinergic, which emits chemicals that put us in a dream state. As we dream, cholinergic neurons in the brain stem begin to fire, setting off erratic pulses of electrical energy called PGO (pontine-geniculate-occipital) waves. These waves travel up the brain stem into the visual cortex, stimulating it to create dreams. Cells in the visual cortex begin to resonate hundreds of times per second in an irregular fashion, which is perhaps responsible for the sometimes incoherent nature of dreams. This system also emits chemicals that decouple parts of the brain involved with reason and logic. The lack of checks coming from the prefrontal and orbitofrontal cortices, along with the brain becoming extremely sensitive to stray thoughts, may account for the bizarre, erratic nature of dreams. Studies have shown that it is possible to enter the cholinergic state without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims that meditation, worrying, or being placed in an isolation tank can induce this cholinergic state. Pilots and drivers facing the monotony of a blank windshield for many hours may also enter this state. In his research, he has found that schizophrenics have an unusually large number of cholinergic neurons in their brain stem, which may explain some of their hallucinations. To make his studies more efficient, Dr. Allan Hobson had his subjects put on a special nightcap that can automatically record data during a dream. One sensor connected to the nightcap registers the movements of a person’s head (because head movements usually occur when dreams end). Another sensor measures movements of the eyelids (because REM sleep causes eyelids to move). When his subjects wake up, they immediately record what they dreamed about, and the information from the nightcap is fed into a computer. In this way, Dr. Hobson has accumulated a vast amount of information about dreams. So what is the meaning of dreams? I asked him. He dismisses what he calls the “mystique of fortune-cookie dream interpretation.” He does not see any hidden message from the cosmos in dreams. Instead, he believes that after the PGO waves surge from the brain stem into the cortical areas, the cortex is trying to make sense of these erratic signals and winds up creating a narrative out of them: a dream.

head office of the brain’s prefrontal cortex.V Relevant from a prevention standpoint, insufficient sleep during childhood significantly predicts early onset of drug and alcohol use in that same child during their later adolescent years, even when controlling for other high-risk traits, such as anxiety, attention deficits, and parental history of drug use.

Often, people drink to actually quiet down the pre-frontal cortex,’ says neuroscientist Alex Korb. ‘The limbic system is responsible for anxiety itself, but the pre-frontal cortex provides the worry scripts, formulating potential problems. When our mind races and catastrophizes, that’s the pre-frontal cortex.

This is especially true of a region called the prefrontal cortex, which sits above the eyes, and can be thought of as the head office of the brain. The prefrontal cortex controls high-level thought and logical reasoning, and helps keep our emotions in check. When a night owl is forced to wake up too early, their prefrontal cortex remains in a disabled, “offline” state.

The right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing.

Where in the brain does perception occur?” and “What initiates my finger movement, you know, before the large pyramidal cells get fired?”—were the typical questions. “In the prefrontal cortex” was my usual answer, before I skillfully changed the subject or used a few Latin terms that nobody really understood but that sounded scientific enough so that my authoritative-appearing explanations temporarily satisfied them. My inability to give mechanistic and logical answers to these legitimate questions has haunted me ever since—as it likely does every self-respecting neuroscientist.3 How do I explain something that I do not understand? Over the years, I realized that the problem is not unique to me. Many of my colleagues—whether they admit it or not—feel the same way.

The Loving God affects the brain in ways that are remarkably different from the Angry God. People who focus on God’s love develop thicker, richer gray matter in their prefrontal cortex and anterior cingulate cortex. This development offers them better focus, concentration, compassion, and empathy. They have lower stress levels and lower blood pressure, and it’s easier for them to forgive themselves and others. Over time, they even show less activity in the amygdala. Even more, people who believe that God is loving will eventually develop a characteristic asymmetry in the activity of their thalamus. When that happens, God’s love becomes implanted in their sense of identity, and they begin to see the world as being basically safe. This not only allows the believer to experience peace—it also elevates her capacity to take risks for the sake of others. For those who know the Loving God, the risk of being hurt in relationships is less important, because God’s love will transcend that hurt.

In particular, judging one’s own confidence in having seen or heard something—metacognition, or “knowing about knowing” (recall the four-point confidence scale in chapter 2)—is linked to anterior regions of prefrontal cortex.

On this scale, the human brain is 7.5 times bigger than the brain of a typical mammal weighing as much as we do, with all other mammals having smaller encephalization quotients. Why the size of say, the prefrontal cortex, should relate to the size

In human terms what we are doing is using our visual processing (occipital lobe) to offload work from our higher level conscious thinking (prefrontal cortex).

Designers love to ideate broadly and wildly. They love the crazy ideas as much as or more than the sensible ones. Why? Most people think that designers are just “out there” and prefer crazy stuff because they’re edgy, avant-garde, dark-sunglass-wearing kinds of people (think berets, cool shoes, and the hippest restaurants). That may be true, but it’s not the point. Designers learn to have lots of wild ideas because they know that the number one enemy of creativity is judgment. Our brains are so tightly wired to be critical, find problems, and leap to judgment that it’s a wonder any ideas ever make it out! We have to defer judgment and silence the inner critic if we want to get all our ideas out. If we don’t, we may have a few good ideas, but the majority will have been lost—silently imprisoned behind the wall of judgment our prefrontal cortex has erected to safeguard us from making mistakes or looking foolish.

Humans have what is called a triune brain, or a three-part brain. The midbrain or reptilian brain is the oldest part of our brain, where our survival instinct lives; the limbic or mammalian brain is where our emotions live; and finally the neocortex is our thinking brain. Adult humans with a fully developed neocortex are typically operating from the top down, from the neocortex down to the midbrain. This basically means we (normally) don’t bang each other on the sidewalk or resort to fistfights to settle disagreements at work because our moral, rational, thinking brain—the neocortex—asserts control over our base survival instincts. The neocortex, and specifically the prefrontal cortex, is where our judgment, personality, willpower, inhibition, social skills, morality, decision making, planning, and loads of other functions live. If the brain is a car, the survival response (midbrain) is the gas, and the prefrontal cortex is the brake. In alcohol addiction, the top-down control gets flipped, and the survival, animal instinct overrides the rational, thinking brain. This is due to two different causes. First, the prefrontal cortex loses its strength and volume; it’s like a muscle, and the chemical component of alcohol (it’s a neurotoxin, as in it attacks gray matter or the regions of the brain involved in sensory perception, memory, emotions, speech, decision making, and self-control), along with the consistent deferral to the survival instincts, weakens its function. So the part of our brain that is responsible for inhibiting actions (willpower), making decisions, moderating social behavior, constructing our personality, upholding our ethics, and planning our future goes offline. At the same time, the midbrain—which thinks only about the next fifteen seconds, not tomorrow or next year—

Allow all feelings, but not all behavior We might think, If I accept them for who they are, see things from their perspective, and allow all their feelings, do I have to accept all their behavior? This is absolutely not the case. We step in if necessary to stop any inappropriate behavior. As the adult, we often need to act as our toddler’s prefrontal cortex (the rational part of their brain), which is still developing. We can step in to keep them safe. To keep others safe. To keep ourselves safe. To show them they can disagree with others in a respectful way. To show them how to show up and be responsible human beings. Examples: “It’s okay to disagree, but I can’t let you hurt your brother/sister. You sit on this side of me, and you sit on the other.” “I can’t let you hurt me/I can’t let you speak to me that way/I cannot let you hurt yourself. But I see something important is going on, and I am trying to understand.

The right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions. In 2015, researchers at the University of California, San Diego, recorded the breathing patterns of a schizophrenic woman over the course of three consecutive years and found that she had a “significantly greater” left-nostril dominance. This breathing habit, they hypothesized, was likely overstimulating the right-side “creative part” of her brain, and as a result prodding her imagination to run amok. Over several sessions, the researchers taught her to breathe through her opposite, “logical” nostril, and she experienced far fewer hallucinations.

Much of maturity is marked by increased emotional self-regulation. This is when the prefrontal cortex is conscious of what you’re doing and in charge. You can inhibit. But when a kid senses a threat, say, in the form of a stressed or grumpy dad, he doesn’t have a fully developed Pilot to say, “No big deal. The bumps will pass, and we’ll just fly at a different altitude in the meantime.” Instead, he panics. His amygdala takes over. And before you know it, he’s stressed and grumpy, too. If this happens too much, his amygdala becomes larger and even more reactive. In Robert Sapolsky’s words, if stress persists for a long time, the amygdala becomes more and more “hysterical.

When we learn about threats as children, and they are accompanied by strong emotions such as fear, they can remain embedded in the neural circuits of the hippocampus for life. Neuroscientists call these “deep emotional learnings.” Like the old posters, they may have no use in the present. They may even be triggering us to react to threats that are entirely imaginary. Yet once learned, and reinforced by conditioned behavior, they are hard to change. Like the dusty posters in the pubs, they may hang around long after they’ve outlived their usefulness. When the hippocampus isn’t sure what to make of a piece of information, it refers it to the brain’s prefrontal cortex (PFC). That’s the brain’s executive center, the seat of discrimination and knowledge. It takes incoming information from the hippocampus and determines whether the apparent threat is real. For instance, you hear a loud bang and are immediately alarmed. “Gunfire?” wonders the hippocampus. “No,” the PFC tells it. “That was a car backfiring.” The reassured hippocampus then does not pass the alarm to the amygdala. Or perhaps the PFC says, “That group of young men hanging out in the parking lot looks suspicious,” and the hippocampus then signals the amygdala, which puts the body on Code Red. Using that path from the emotional center of the brain to the executive center is crucial to regulating our emotions. Because it involves a feedback loop with information going first to the PFC and then back to the hippocampus from the PFC, it’s called the long path: hippocampus > PFC > hippocampus > amygdala > FFF. The long path is the default for people with effective emotional self-regulation. 3.8. The long path. 3.9. The short path. In people with poor emotional self-regulation, such as patients with PTSD, this circuit is impaired. They startle easily and overreact to innocuous stimuli. The hippocampus cuts out the PFC. Instead of referring incoming threats to the wise discrimination of the primate brain, where the bang can be categorized as “car backfiring,” the hippocampus treats even mild stimuli as though they are life-threatening disasters and activates the amygdala. This short-circuit of the long path creates a short path: hippocampus > amygdala > FFF. The short circuit improves reaction speed, but at the expense of accuracy.

If your long path is short-circuited by stress, and your brain is using the short path instead, you might be so alarmed at the mere thought of a shark that you have a panic attack just thinking about taking a swim in the ocean. All the body’s machinery of FFF then gets engaged by this imaginary threat, just as if you were nose to nose with Jaws. Your gut clenches, your heart races, your breathing becomes fast and shallow, and your focus narrows to the point where you can’t think about anything other than the threat. This takes a huge biological toll on the body. High adrenaline produces dramatic reductions in life span. Stressed people have much more disease and live much shorter lives than unstressed people. Whatever form stress takes—depression, anxiety, or PTSD—correlates with higher rates of cancer, diabetes, and heart disease. The deficits in the life spans of stressed people are measured in decades rather than years. In meditators, the amygdala is quiet. It becomes even quieter with practice. The difference in amygdala activation between the longest-term meditators and their less-experienced peers has been measured. The adepts show 400% less reactivity to stressful events. But even in novices who practice mindfulness for 30 hours over 8 weeks, decreased amygdala activity is found. Other structures within the midbrain or limbic system work together with the hippocampus and amygdala. One of them, the thalamus, is like a relay station. Close to the corpus callosum, it identifies information coming in from the senses like touch, hearing, and taste, and directs it to the consciousness centers of the prefrontal cortex. The thalamus typically becomes more active during meditation, as it works harder to suppress sensory input (like “that buzzing mosquito” or “this chair is too hard”) that pulls us out of Bliss Brain. With the hippocampus regulating emotion, the thalamus regulating sensory input, and the long path in good working order, stress-inducing signals aren’t sent to the amygdala. In turn, all the body’s FFF machinery remains offline. This produces corresponding biological benefits. Heart rhythm is even. Respiration is deep and slow. Digestion is effective. Immunity is high. That’s why so many studies show pervasive health and longevity benefits among meditators.

That I-me-mine self is constructed largely in and by the brain’s medial prefrontal cortex. It’s assisted by the medial temporal lobe, the parietal lobe, and the PCC of which we’ll hear more in Chapter 3. This brain network allows us to do things that other animals cannot. We can compose music and calculate math. We have a sense of time that includes past and future, allowing us to delay gratification to meet our goals. We are able to contemplate the very nature of consciousness, using the brain to think about our thoughts. Yet consciousness is always turned on. Whether we’re focusing on a task using the TPN or listening to the rambling of the demon, the engine is running at 2,000 RPM. There’s no easy way of shutting off our thoughts, of getting outside the self. In his book The Curse of Self, psychologist Mark Leary of Duke University shows the many downsides of this perpetual self-awareness. He shows that it leads to many forms of suffering, including “depression, anxiety, anger, jealousy, and other negative emotions.” He concludes that self-awareness is “single-handedly responsible for many, if not most of the problems that human beings face as individuals and as a species.” We can summarize this state in a single word: “selfing.” Meditation quiets self-awareness and gives us relief from selfing. In experienced meditators, the “self” parts of the prefrontal cortex go offline. The jargon for this is “hypofrontality.” Hypo is the opposite of hyper, and hypofrontality means the shutting down of the brain’s frontal lobes. The inner critic shuts up. The negative self-talk about “who I am” and “what I do” and “what other people think of me” ceases. We quit selfing. This gives us a sense of identity beyond the suffering self and all the roles it plays. Psychologist Robert Kegan is the former head of adult psychology at Harvard University. He calls the transcendence of selfing the “subject-object shift.” In altered states, we get out of the subjective selves we normally think we are. To be objective, you can’t be the object you’re contemplating. So when the brain enters a state of hypofrontality and we’re no longer enmeshed in the local self, we gain perspective on it. We realize we’re more than that. To realize it’s an object we’re observing, we have to step out of the suffering self. We see the demon from a distance as we step into an identity that is vastly greater than the one we previously inhabited. 2.8. When we make the subject-object shift we escape the limitations of the finite self. Kegan believes that making this jump is the most powerful way to facilitate personal transformation. He says that after it makes the subject-object shift, “the self is more about movement through different states of consciousness than about defending and identifying with any one form.

In this altered state, the parts of the brain associated with happiness, compassion, and equanimity light up. Kotler and Wheal describe four experiential characteristics of these ecstatic states. They are: Selflessness Timelessness Effortlessness Richness 2.9. The Enlightenment Circuit associated with Bliss Brain. Brain regions include those involved with attention (insula and anterior cingulate cortex), regulating stress and the DMN (ventromedial prefrontal cortex and limbic system), empathy (temporoparietal junction, anterior cingulate cortex, and insula), and regulating self-awareness (precuneus and medial prefrontal cortex). They summarize these four qualities with the acronym STER. The benefit of this characterization of altered states is that it’s not linked to a philosophy, religion, guru, or cult. It focuses on the experiences common to transcendent states, rather than the paths by which people reach them. Selflessness represents a letting go of the sense of I-me-mine and all the elements that keep us stuck in our suffering default local personalities. Timelessness means coming into the present moment. That’s the place where we’re free of the regrets of the past as well as worries about the future. We’re in the timeless now, the only place we can experience the state of flow. In Huxley’s words, “the eye recovers some of the perceptual innocence of childhood,” while “Interest in space is diminished and interest in time falls almost to zero.” In this place, we relax into a sense of effortlessness. We feel connected to the universe and all living beings, our lives infused with a sense of richness. In this state we make connections between ideas, and the coordination between all the parts of our brains is enhanced. These rich experiences feel deeply significant. Kotler and Wheal document the human drive for ecstasy as far back in time as the ancient Greeks, saying that Plato describes it as “an altered state where our normal waking consciousness vanishes completely, replaced by an intense euphoria and a powerful connection to a greater intelligence.” Our English word “ecstasy” comes from the Greek words ex and stasis. It means getting outside (ex) the static place where your consciousness usually stands (stasis). That’s Bliss Brain. When you quiet the demon, you open up space in consciousness for connection with the universe. This produces a rich experience in which time, space, and effort fall away, and you merge with the rich infinity of nonlocal mind.

A full spectrum of products exploit the disruptions of modern life to help us cope with this stress, to make us temporarily less unhappy—and to hook us with a promised return to some imagined state of bliss. The physical environment drives us, through anxiety and opportunity, to the kinds of behaviors that generate more inflammation: overeating, drug use, and self-isolation.118 Chronic stress makes the body vulnerable to addiction,119 increasing levels of emotional stress cause decreased impulse control,120 and the more chronic the stress becomes, the more maladaptive the behavior becomes.121 Chronic stress dampens activity in the prefrontal cortex—the part of the brain responsible for rational decision making and self-control—and heightens activity in the limbic system, which includes the amygdala, an ancient center of the brain that guides impulsive behavior.122 Global industries intuitively understand this connection between the endocrine and nervous systems, encouraging addiction and overconsumption as a path to happiness, a dynamic that David Courtwright calls “limbic capitalism.”123 As Facebook cofounder Sean Parker explained, social media are engineered to hijack our need for social connection, offering “a little dopamine hit” to the reward centers of the brain through likes and retweets and views.124 This is not exactly an accurate description of the complex neurobiology at play, but it is a fair assessment of how Facebook keeps us coming back for more.125

Chemically induced joy comes at a cost. That cost can be high. Very, very high. So high that you’re going to think twice after reading what science has to say about drug use. One study found that adolescents who smoke just a couple of joints of marijuana show changes in their brains. That’s not a couple of years of smoking or the decades that some adults rack up. It’s just two joints. A research team led by Dr. Gabriella Gobbi, a professor and psychiatrist at the McGill University Health Center in Montreal, discovered that teenagers using cannabis had a nearly 40% greater risk of depression and a 50% greater risk of suicidal ideation in adulthood. Dr. Gobbi stated that “given the large number of adolescents who smoke cannabis, the risk in the population becomes very big. About 7% of depression is probably linked to the use of cannabis in adolescence, which translates into more than 400,000 cases.” The research that revealed these startling numbers was not just a single study of adolescent marijuana use. It was a meta-analysis and review of 11 studies with a total of 23,317 teenage subjects followed through young adulthood. Further, Gobbi’s team only reviewed studies that provided information on depression in the subjects prior to their cannabis use. “We considered only studies that controlled for [preexisting] depression,” said Dr. Gobbi. “They were not depressed before using marijuana, so they probably weren’t using it to self-medicate.” Marijuana use preceded depression. The specific findings of Gobbi’s research include: The risk of depression associated with marijuana use in teens below age 18 is 1.4 times higher than among nonusers. The risk of suicidal thoughts is 1.5 times higher. The likelihood that teen marijuana users will attempt suicide is 3.46 times greater. In adults with prolonged marijuana use, the wiring of the brain degrades. Areas affected include the hippocampus (learning and memory), insula (compassion), and prefrontal cortex (executive functions). The authors of one study stated that “regular cannabis use is associated with gray matter volume reduction in the medial temporal cortex, temporal pole, parahippocampal gyrus, insula, and orbitofrontal cortex; these regions are rich in cannabinoid CB1 receptors and functionally associated with motivational, emotional, and affective processing. Furthermore, these changes correlate with the frequency of cannabis use . . . [while the] . . . age of onset of drug use also influences the magnitude of these changes.” A large number of studies show that cannabis use both increases anxiety and depression and leads to worse health. Key parts of your brain shrink more, based on how early you began smoking weed, and how often you smoke it. That’s a “high” price to pay.

These areas are emerging as key regions changed by meditation: Amygdala, hippocampus, thalamus, and other structures in the emotional midbrain. Central in stress, relaxation, memory, and learning. Anterior cingulate cortex. Involved in controlling the focus of attention. Caudate nucleus. Involved in memory storage and processing, the caudate nucleus plays an essential role in how the brain learns, using feedback from past experience to influence current actions. Areas of the cingulate cortex responsible for regulating the brain’s own activity. Insula. Makes us aware of our internal emotional states and body sensations. Medial prefrontal cortex. Influences emotional responses in memory and decision-making. Orbitofrontal cortex. Involved with rational thought, impulse control, cognitive reasoning, and personality. Posterior cingulate cortex. One of the two nodes in the DMN, it’s active in memory retrieval and attaching significance to perceptions. Prefrontal cortex centerline regions related to paying close attention. Somatomotor areas processing pain, touch, and orientation of the body in space. Striatum, as well as limbic and prefrontal regions involved in emotional self-control and craving. We’ll look at each of these in turn because understanding their functions will show you how they contribute to your meditation practice. By the end of this chapter, you’ll understand each region activated in Bliss Brain, how they integrate into four distinct networks, and how these networks coordinate to produce elevated states of flow.

Big bundles of neurons conduct information up through the spinal cord into the brain. Sitting at the top of this conduit is the thalamus. In Chapter 3, I compared the thalamus to a relay station, conducting information from the senses to the prefrontal cortex. During meditation, the thalamus is active, as meditators suppress sensory input that might pull them out of Bliss Brain. Andrew Newberg finds that one of the two lobes of the thalamus is often more active than the other. One interpretation of this activity may be the meditator’s awareness that she is more than her body and that she is connected to nonlocal mind, not just her senses. It’s the thalamus that is telling us what is and isn’t reality, and this is affected by the larger reality in which the meditator is absorbed. In long-term meditators, this asymmetry persists when they open their eyes. As the meditator experiences oneness, the universe will, in Newberg’s words, “be sensed as real. But it will not be a ‘symmetrical’ reality. Instead, it will be perceived ‘asymmetrically,’ meaning that the reality will appear different from one’s normal perception.” The nonlocal universe may be perceived as more real than local sensory reality and, as Newberg observes, “The more frequently a person engages in meditative self-reflection, the more these reality centers [like the thalamus] change.

These are places close to the surface, such as the temporoparietal junction and dorsolateral prefrontal cortex, in which meditation produces increases in brain tissue. As it grows, pushing against the skull to produce increased folding, you, too, may feel this pressure. THE SELFING CONTROL NETWORK In Chapter 2, we learned about “selfing,” the tendency of the DMN to focus on the self, with its bias to suffering and negativity. The brain also has a Selfing Control Network that suppresses this activity. Once we’ve learned to tame our emotions and focus our attention, we abandon our petty self-absorption and surrender into ecstatic states. When the Selfing Control Network is engaged, our obsession with selfing diminishes as we are drawn into unity consciousness with nonlocal mind.

The pons is active during meditation, as we breathe deeply and regularly. It’s associated with the production of delta and theta waves in the brain, which research shows turns on a host of healthy processes in your cells. These include increased stem-cell production and the repair of skin, bone, muscle, nerves, and cartilage. These brain waves also lengthen our telomeres, the most reliable marker of longevity. A remarkable ability of humans is that we are able to activate or deactivate all of these brain regions by consciousness alone. We can shift our thoughts deliberately with meditative practices or simply by focusing on different stimuli. The brain responds accordingly. We’ll see the extraordinary neural effects of this superpower of “selective attention” in Chapter 6, and the evolutionary implications in Chapter 8. Pons Activation Benefits Increases Decreases Quality REM sleep Insomnia Cell repair Longevity Energy Cell metabolism Melatonin Delta brain waves Theta brain waves Dream frequency and quality Lucid dreaming To the Brain, Imagination Is Reality For thousands of years, sages have assured us that our minds create our reality. In Proverbs 23:7, the poet tells us that, “As a man thinketh in his heart, so is he.” Two thousand years ago the Buddha said, “We are what we think. All that we are arises with our thoughts. With our thoughts, we make the world.” Now neuroscience is showing us how true this is. An ingenious study measured how our brains respond to scenarios that exist only in our imaginations. A research team at the University of Colorado at Boulder took 68 people and gave them a mild electric shock accompanied by a sound. They were then divided into three groups. The first group heard the sound repeatedly, though this time without the shock. The second group imagined the sound in their heads repeatedly. The third group imagined the pleasant natural music of rain and birds. The group imagining the sound showed the same brain activity as the one actually hearing the sound. Two brain regions, the ventromedial prefrontal cortex and the nucleus accumbens, lit up. As we’ve seen, the first regulates emotions like fear in the limbic system, while the second processes reward and aversion. Later, people in the “rain and birds” group were still afraid of the sound even when it was repeated many times without the shock. But those in the group that heard the real sound, as well as those imagining it, unlearned their fear. In neuroscience, this revision of reality is called “extinction learning.

The Emory researchers who identified the four phases of meditation found that when meditators slip out of the focused attention of the TPN and into Mind Wandering, the DMN activates. The wandering mind of the DMN has a “me” orientation, focusing on the self. It may flit from what’s going on at the moment (“Is that a mosquito buzzing?”) to future worries (“I’m nervous about next week’s exam”) to the past (“I’m so mad at my brother Jim for calling me a sissy at my fifth birthday party”). The precuneus contributes to both self-referential focus and episodic memory. Disturbing memories are played and replayed. The idle brain defaults to what is bothering us, both recent and long-past events. These egocentric musings of the wandering mind form the fabric of our sense of self. When you quiet your TPN in meditation, you open up a big empty space in consciousness. For a few moments, the brain is quiet, and you feel inner peace. Then the engine starts revving. The DMN kicks in, bringing with it a cascade of worries and random thoughts. You’re doing 2,000 RPM in Park, but going nowhere. And it gets worse. The DMN has a rich neural network connecting it with other brain regions. Through this, it busily starts recruiting other brain regions to go along with its whining self-absorption. It commandeers the brain’s CEO, the prefrontal cortex. This impairs executive functions like memory, attention, flexibility, inhibition, planning, and problem-solving. 2.5. Nerves from the Default Mode Network reach out to communicate with many other parts of the brain. The DMN also recruits the insula, a region that integrates information from other parts of the brain. It has special neurons triggered by emotions that we feel toward other people, such as resentment, embarrassment, lust, and contempt. We don’t just think negative thoughts; we feel them emotionally too. At this stage, the meditator isn’t just wallowing in a whirlwind of self-centered thoughts. The DMN has taken the brain’s CEO hostage, while through the insula it starts replaying all the slights, insults, and disappointments we’ve experienced in our relationships. The quiet meditative space we experienced just a few moments before has been destroyed. This drives meditators absolutely nuts. No sooner do they achieve nirvana, the still, quiet place of Bliss Brain, than the DMN serves up a smorgasbord of self-absorbed fantasies. It pulls us into negative emotional states—then drags the rest of the brain along behind it. The DMN. Hmm . . . that acronym reminds me of something: “the DeMoN.” The DMN is the demon that robs me of the inner peace I’m seeking through meditation

In alcohol addiction, the top down control gets flipped and the survival animal instinct overrides the rational thinking brain. It does this due to two different causes. First the prefrontal cortex loses its strength and volume. It's like a muscle and the chemical component of alcohol is a neurotoxin, as in it attacks gray matter, or the regions of the brain involved in sensory perception, memory, emotions, speech, decision making, and self-control. Along with the consistent deferral to the survival instincts, it weakens its function so the part of our brain that is responsible for inhibiting actions or willpower, making decisions, moderating social behavior, constructing our personality, upholding our ethics, and planning our future, goes offline. At the same time, the midbrain, which thinks only about the next 15 seconds, not tomorrow, or next year, becomes more powerful. It believes alcohol is necessary for survival, again more than food, more than sex, and it's on a mission to get it.

Willpower and brain capacity. Most of us are confused about what willpower really is. We tend to think some people have it in spades and that others like those with chemical and behavioral addictions are lacking in it. That's exactly how I saw myself as a person with no self-control or willpower which was not at all true. While impulse control was indeed a skill I had to hone. For instance through meditation, and mindfulness - staying present with feelings and reactions. Willpower, as in repression or inhibiting a desire. It isn’t a skill. It's a finite cognitive function known as inhibition. To understand a little bit more how willpower or inhibition works, a few pieces of information will help. First, willpower is one of five functions delegated to the prefrontal cortex or PFC. The other four functions are decision making, understanding, memorizing, and recalling. Second, it's important to know that the brain requires a crapload of energy from the body. It accounts for about 2% of our body mass and consumes about 20% of our energy. Most of our brain functions are automatic and don't require conscious processing. Like the beating of your heart, or a habit like driving a car. These automatic processes don't burn up metabolic resources. The PFC on the other hand requires a massive amount of energy or glucose to work. The same way you need energy to run a mile you need energy to make decisions or memorize facts. And this energy is not inexhaustible. We wake up every day with only so much gas in our tank to fuel our PFC. And we burn through it fairly quickly. What this means for willpower is that 1) it's a finite resource with only so much of it available to us each day and 2) it's a resource shared with other functions. Every time you solve a problem, make a decision, memorize a fact, remember something, or try not to do something, like eat that second cookie, or check your Instagram for the 14th time, you are draining your willpower reserves. Trying harder doesn't work when you've got nothing left in you to feel the effort. The thing about the Pfc is that there's no way to give it more gas. So there's no way to increase your willpower, or decision making, understanding, memorizing or recall. What you can do is approach those five functions as if they are precious resources because they are and plan your day in a way that uses them carefully. By creating more automation or habits so that you aren't using your decision making and willpower as often.

Your prefrontal cortex can also rein in your amygdala. It can tell your amygdala to relax—

There are many interpretations of the word “mindfulness.” Its most common interpretation involves the use of meditation. But mindfulness includes many other aspects. One is contemplation. Being mindfully aware may sound difficult at first, but it’s not. Nor is it something we have to work hard to achieve. Mindful awareness is simply paying attention to what is happening now. In doing nothing other than living in the moment for a few minutes, we can let thoughts and feelings come and go without holding on to them or judging them. In doing so, we build the muscles of concentration, observation, and relaxation all at the same time. This is different from thinking, in which we often judge each moment on what has been or what could be. I sometimes call it mind-full awareness because the mind is full of nothing but a gentle focus on the breath. It is the direct opposite to being mind-less. Mindlessness is when we are on autopilot and not paying attention to the present moment. We’ve all been there. We sometimes feel as though we are sleepwalking through our lives. Minutes, hours, even days can go by that we don’t fully recall because we don’t feel aware of what is happening. By sitting and mindfully breathing for ten minutes a day, in as little as eight weeks you strengthen the part of the prefrontal cortex involved in generating positive feelings and diminish the part that generates negative ones. —Richard Davidson, PhD Sometimes in mindlessness we find ourselves reacting automatically in negative ways—lashing out or saying things we later regret. We ask ourselves, “Why did I do that?” or “Who was in charge of my mouth?” It doesn’t have to be this way. We all have the ability to become more present. First we have to truly believe it is possible. Then we create the intention. The more we tune in to our own thoughts and feelings, the more choices we give ourselves in terms of our responses. The key to all these mindful practices is to keep going and not be overcritical of ourselves. Whenever we become aware that our minds have wandered from our practice, we just gently refocus. Learning expert Tim Gallwey calls this “awareness without judgment” and claims that it is one of the greatest tools for learning in what he describes as the “inner game.” The more we reinforce this message, the more we improve our own focus—and the more we help our children accept that they can make mistakes without being overcritical of themselves. One

Your brain likes to take shortcuts if it can, and most of the time, it’s on autopilot. But when your brain notices that you’ve made a mistake, the anterior cingulate alerts the prefrontal cortex, “Hey, this is something we should pay attention to.

Over the last few decades there have been some fascinating studies that revealed that people who get a physical reaction from music might have structural differences in their brain. Some people have a physical response while others will just hear the songs, enjoy it, but it doesn’t transport them anywhere. Brain scans have shown that the people who get a more palpable response have a higher volume of fibres that connect their auditory cortex to the areas associated with emotional processing, which means the two areas communicate better. They also tend to have a higher prefrontal cortex, which is involved in certain areas of understanding, like interpreting the world more metaphorically, and that obviously helps them develop not just a natural gift interpreting music, but also creating it.

People who have trained their brains to think in the positive, actually wire more neural networks into the left prefrontal cortex of their brain.

The dance between sun and clouds, the discourse between meadow and flowers, I knew, and even the imagined sonata of stream and bird had touched a memory too drowsy to rise to consciousness. A memory the shade of night almost resurfaced upon my mind; the sensation of breeze almost linked to the isolated neuron clusters. I embraced that nausea and tried to nourish it, hoping it would mature into a newborn image, an episode in my personal history, a defining symbol of my self. If only I could reach deeper into that emotion, link the neurons between my amygdala and my prefrontal cortex, I might touch my forgotten self.

Another Japanese study in humans from 2013 found that mouthbreathing delivered a disturbance of oxygen to the prefrontal cortex, the area of the brain associated with ADHD. Nasal breathing had no such effects.

Be with the experience and explore its different parts. Label them to yourself: tense…worried…annoyed…sad. This will increase activity in the prefrontal cortex (the part of the brain behind your forehead), which will help with top-down self-control. Naming to yourself what you are experiencing will also decrease activity in the amygdala—which functions like an alarm bell in the brain—and help you calm down.

Stimulus discrimination is a thinking thing, not an emotions thing. Which means it happens in the prefrontal cortex, and once the brainstem gets into freak-out mode, it’s really hard to get the prefrontal cortex up and running again. But we can do it. And we are going to talk about how we retrain our brain to respond in ways that better suit life as it is now instead of life as it was in the past. Our stimulus discrimination response is based on all of our past experiences and habits, and that response is even more ingrained if those experiences were traumatic ones. If a stimulus is attached to a strong memory, the body starts shooting off hormones and neurotransmitters to prepare itself for response. Brains don’t really have new thoughts so much as different configurations and mash-ups of old thoughts. This is why a military vet may freak out at seeing garbage by the side of the road, after being in Iraq and driving through areas replete with improvised explosive devices. This is why an individual who was abused may freak out by smelling a certain scent they associate with their abuser. The brain knows its history. It has been trained to do whatever it can to remain safe. It’s creating stories about your current experience or possible future experiences based on its past information. It doesn’t realize or doesn’t trust that you actually ARE safe.

The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

The emotional brain has first dibs on interpreting incoming information. Sensory Information about the environment and body state received by the eyes, ears, touch, kinesthetic sense, etc., converges on the thalamus, where it is processed, and then passed on to the amygdala to interpret its emotional significance. This occurs with lightning speed. If a threat is detected the amygdala sends messages to the hypothalamus to secrete stress hormones to defend against that threat. The neuroscientist Joseph LeDoux calls this “the low road.” The second neural pathway, the high road, runs from the thalamus, via the hippocampus and anterior cingulate, to the prefrontal cortex, the rational brain, for a conscious and much more refined interpretation. This takes several microseconds longer. If the interpretation of threat by the amygdala is too intense, and/or the filtering system from the higher areas of the brain are too weak, as often happens in PTSD, people lose control over automatic emergency responses, like prolonged startle or aggressive outbursts.

The prefrontal cortex is what we use to se goals, make plans, divide a large project up into smaller pieces, exercise impulse control, and decide what we're going to pay attention to. As I mentioned earlier, the prefrontal cortex is the last region to develop in childhood and doesn't fully mature until well after puberty - into the late twenties. Because of it's involvement in impulse control, there have been several cases in which defense attorneys argued that eighteen-to-twenty-year-olds shouldn't be held responsible for law-breaking acts because they lack an adult like, mature prefrontal cortex that would allow them to exercise adult-like impulse control. The prefrontal cortex is also the first cortical region to show wear and tear as we get older. "That is why one of the most significant problems in older adults is the ability to keep track of thoughts and prevent stray ones from interfering," says Art Shimamura. "Brain fitness as we age depends significantly on maintaining a healthy and active prefrontal cortex. The more we engage this brain region during daily activities, the better we will be able to control our thoughts and think flexibly.