Physiological Best Quotes

How can we say nobody's perfect if there is no perfect to compare to? Perfection implies that there really is a right and wrong way to be. And what type of perfection is the best type? Moral perfection? Aesthetic? Physiological? Mental?

Pondering all this down in Reva's black room under her sad, pilly sheets, I felt nothing. I could think of feelings, emotions, but I couldn't bring them up in me. I couldn't even locate where my emotions came from. My brain? It made no sense. Irritation was what I knew best - a heaviness on my chest, a vibration in my neck like my head was revving up before it would rocket off my body. But that seemed directly tied to my nervous system - a physiological response. Was sadness the same kind of thing? Was joy? Was longing? Was love?

Headache, hmm?" His expression went serious. "Do you know what's the best cure for that?" "What?" "Orgasm." He said it so matter-of-factly I had to sputter a laugh. "Multiple, if possible," he continued. "It's a proven medical fact that one physiologic event, like orgasm, can cancel out the effects of another physiological process, such as a headache." His expression was perfectly serious, but I said, "You're full of shit." "Perhaps. If so, you should call my bluff. Just open the door and we'll test it out.

Humans are built to move. We evolved under conditions that required daily intense physical activity, and even among individuals with lower physical potential, that hard-earned genotype is still ours today. The modern sedentary lifestyle leads to the inactivation of the genes related to physical performance, attributes that were once critical for survival and which are still critical for the correct, healthy expression of the genotype. The genes are still there, they just aren't doing anything because the body is not stressed enough to cause a physiological adaptation requiring their activation. The sedentary person's heart, lungs, muscles, bones, nerves and brain all operate far below the level at which they evolved to function, and at which they still function best.

The dissociation between fear and aggression is evident in violent psychopaths, who are the antithesis of fearful—both physiologically and subjectively they are less reactive to pain; their amygdalae are relatively unresponsive to typical fear-evoking stimuli and are smaller than normal.34 This fits with the picture of psychopathic violence; it is not done in aroused reaction to provocation. Instead, it is purely instrumental, using others as a means to an end with emotionless, remorseless, reptilian indifference.

To me, the best, if not the only function of imaginative writing, is to lead the human imagination outward, to take it into the vast external cosmos, and away from all that introversion and introspection, that morbidly exaggerated prying into one's own vitals—and the vitals of others—which Robinson Jeffers has so aptly symbolized as "incest." What we need is less "human interest," in the narrow sense of the term—not more. Physiological—and even psychological analysis—can be largely left to the writers of scientific monographs on such themes. Fiction, as I see it, is not the place for that sort of grubbing.

I submit a body of facts which cannot be invalidated. My opinions may be doubted, denied, or approved, according as they conflict or agree with the opinions of each individual who may read them; but their worth will be best determined by the foundation on which they rest—the incontrovertible facts.

The best advice I was ever given for testifying in court was simply to “Take . . . your . . . time.

In other cases the challenge is to appreciate how, though human physiology resembles that of other species, we use the physiology in novel ways.

The subjective emotion we feel is the brain’s best predictive guess that explains the [incoming] interoceptive information at a whole bunch of hierarchical levels,” said Seth. “It’s not just cognition looking down at physiology and interpreting it.

The capital ... shall form a fund, the interest of which shall be distributed annually as prizes to those persons who shall have rendered humanity the best services during the past year. ... One-fifth to the person having made the most important discovery or invention in the science of physics, one-fifth to the person who has made the most eminent discovery or improvement in chemistry, one-fifth to the one having made the most important discovery with regard to physiology or medicine, one-fifth to the person who has produced the most distinguished idealistic work of literature, and one-fifth to the person who has worked the most or best for advancing the fraternization of all nations and for abolishing or diminishing the standing armies as well as for the forming or propagation of committees of peace.

As the arrangements of life no longer allow time for pleasure conscious of itself, replacing it by the performance of physiological functions, de-inhibited sex is itself de-sexualized. Really, they no longer want ecstasy at all, but merely compensation for an outlay that, best of all, they would like to save as superfluous.

When you feel overwhelmed or unfocused, what do you do? I change my physiology. If I am near waves, I go surf them. If not, a short, intense kettlebell workout, a bike ride, a swim, a cold shower or ice plunge, Wim Hof or heart rate variability breathing [see Adam Robinson, for a description]. It’s remarkable how the mind follows the body.

Twelve chapters later, I’ve learned how our brains control many aspects of our physiology, including the tools that the body has available—from hormones and natural painkillers to the weapons of the immune system—to ease symptoms and fight disease. Instead of responding purely to physical circumstances, I’ve seen how the brain uses our perception of our environment, including memories of the past and predictions about the future, to decide how best to allocate its resources. These processes can have an effect within seconds, or they can influence our physiology for years to come.

Man is often lost in a technological, physiological, astrological lack of logical existence that can best be described as a whole lot of nothing lightly dashed with an obvious hint of Scotch,” Hal says.

There are various kinds of depression, to be sure, and some are the result of the complex physical and physiological disorders. But there are times when we are spiritually depressed for no good reason. There are times when the best thing to do with our feelings is to challenge them: "Why are you cast down, and why are you in turmoil within me? Hope in God; for I shall again praise Him, my salvation and my God (Psalm 42:11).

…I felt nothing. I could think of feelings, emotions, but I couldn't bring them up in me. I couldn't even locate where my emotions came from. My brain? It made no sense. Irritation was what I knew best—a heaviness on my chest, a vibration in my neck like my head was revving up before it would rocket off my body. But that seemed directly tied to my nervous system—a physiological response. Was sadness the same kind of thing? Was joy? Was longing? Was love?

We face no such difficulty if we see that what is being transmitted genetically is not ADD or its equally ill-mannered and discombobulating relatives, but sensitivity. The existence of sensitive people is an advantage for humankind because it is this group that best expresses humanity’s creative urges and needs. Through their instinctual responses the world is best interpreted. Under normal circumstances, they are artists or artisans, seekers, inventors, shamans, poets, prophets. There would be valid and powerful evolutionary reasons for the survival of genetic material coding for sensitivity. It is not diseases that are being inherited but a trait of intrinsic survival value to human beings. Sensitivity is transmuted into suffering and disorders only when the world is unable to heed the exquisitely tuned physiological and psychic responses of the sensitive individual.

Our best minds are not wasting their time trying to give meaning to death. Instead, they are busy investigating the physiological, hormonal and genetic systems responsible for disease and old age. They are developing new medicines, revolutionary treatments and artificial organs that will lengthen our lives and might one day vanquish the Grim Reaper himself.

Moral for psychologists. -- Not to go in for backstairs psychology. Never to observe in order to observe! That gives a false perspective, leads to squinting and something forced and exaggerated. Experience as the wish to experience does not succeed. One must not eye oneself while having an experience; else the eye becomes "an evil eye." A born psychologist guards instinctively against seeing in order to see; the same is true of the born painter. He never works "from nature"; he leaves it to his instinct, to his camera obscura, to sift through and express the "case," "nature," that which is "experienced." He is conscious only of what is general, of the conclusion, the result: he does not know arbitrary abstractions from an individual case. What happens when one proceeds differently? For example, if, in the manner of the Parisian novelists, one goes in for backstairs psychology and deals in gossip, wholesale and retail? Then one lies in wait for reality, as it were, and every evening one brings home a handful of curiosities. But note what finally comes of all this: a heap of splotches, a mosaic at best, but in any case something added together, something restless, a mess of screaming colors. The worst in this respect is accomplished by the Goncourts; they do not put three sentences together without really hurting the eye, the psychologist's eye. Nature, estimated artistically, is no model. It exaggerates, it distorts, it leaves gaps. Nature is chance. To study "from nature" seems to me to be a bad sign: it betrays submission, weakness, fatalism; this lying in the dust before petit faits [little facts] is unworthy of a whole artist. To see what is--that is the mark of another kind of spirit, the anti-artistic, the factual. One must know who one is. Toward a psychology of the artist. -- If there is to be art, if there is to be any aesthetic doing and seeing, one physiological condition is indispensable: frenzy. Frenzy must first have enhanced the excitability of the whole machine; else there is no art. All kinds of frenzy, however diversely conditioned, have the strength to accomplish this: above all, the frenzy of sexual excitement, this most ancient and original form of frenzy. Also the frenzy that follows all great cravings, all strong affects; the frenzy of feasts, contests, feats of daring, victory, all extreme movement; the frenzy of cruelty; the frenzy in destruction, the frenzy under certain meteorological influences, as for example the frenzy of spring; or under the influence of narcotics; and finally the frenzy of will, the frenzy of an overcharged and swollen will. What is essential in such frenzy is the feeling of increased strength and fullness. Out of this feeling one lends to things, one forces them to accept from us, one violates them--this process is called idealizing. Let us get rid of a prejudice here: idealizing does not consist, as is commonly held, in subtracting or discounting the petty and inconsequential. What is decisive is rather a tremendous drive to bring out the main features so that the others disappear in the process. In this state one enriches everything out of one's own fullness: whatever one sees, whatever one wills, is seen swelled, taut, strong, overloaded with strength. A man in this state transforms things until they mirror his power--until they are reflections of his perfection. This having to transform into perfection is--art. Even everything that he is not yet, becomes for him an occasion of joy in himself; in art man enjoys himself as perfection.

Organisms that spend their calories unwisely, in the eyes of natural selection, will reproduce less. The next generation will be full of offspring from the careful, strategic spenders—those who were best at acquiring energy, and who allocated those calories most effectively. Since physiology and behavioral tendencies are inherited, these offspring will tend to spend their calories like their parents did.

Suppose you unexpectedly see a person you care about. Suddenly you feel the love you have, for that person. Let's follow the flow of information from the visual system through the brain to the point of the experience of love as best we can. First of all, the stimulus will flow from the visual system to the prefrontal cortex (putting an image of the loved one in working memory). The stimulus also reaches the explicit memory system of the temporal lobe and activates memories and integrates them with the image of the person. Simultaneously with these processes, the subcortical areas presumed to be involved in attachment will be activated (the exact paths by which the stimulus reaches these areas is not known, however). Activation of attachment circuits then impacts on working memory in several ways. One involves direct connections from the attachment areas to the prefrontal cortex (as with fear, it is the medial prefrontal region that is connected with subcortical attachment areas). Activation of attachment circuits also leads to activation of brain stem arousal networks, which then participate in the focusing of attention on the loved one by working memory. Bodily responses will also be initiated as outputs of attachment circuits, and contrast with the alarm responses initiated by fear and stress circuits. We approach rather than try to escape from or avoid the person, and these behavioral differences are accompanied by different physiological conditions within the body. This pattern of inputs to working memory from within the brain and from the body biases us more toward an open and accepting mode of processing than toward tension and vigilance. The net result in working memory is the feeling of love.

WHAT EES ALL DEES STUFF? IN AFRICA WE DOAN HAVE ALL DEES STUFF!! WE HAVE DEE BABEE!!!" His message was simple. It goes to the heart of what we in HypnoBirthing frequently puzzle over: Why has all the "stuff" that denies the normalcy of birth and portrays it as an inevitably risky and dangerous medical event become a routine part of most childbirth education classes? Why are couples in a low- or no-risk category being prepared for circumstances that only rarely occur? Even more puzzling, why do parents accept the negative premise that birth is a dangerous, painful ordeal at best or a medical calamity at worst? Why do they blindly accept the "one-size-fits-all" approach?" If what couples are hearing in childbirth classes is far removed from what they want their birthing experiences to be, why do they spend so much time entertaining negative outcomes that can color and shape their birth expectations and ultimately affect their birth experience? In other words, if it's not what they're wanting, why would they "go there"? In HypnoBirthing, we doan have all dees stuff, and deliberately so." HypnoBirthing helps you to frame a positive expectation and to prepare for birth by developing a trust and belief in your birthing body and in nature's undeniable orchestration of birthing. By teaching you the basic physiology of birth and explaining the adverse effect that fear has upon the chemical and physiological responses of your body we help you to learn simple, self-conditioning techniques that will easily bring you into the optimal state of relaxation you will use during birthing. This will allow your birthing muscles to fully relax. In other words, we will help you prepare for the birth your plan and want for yourselves and your baby, rather than the birth that someone else directs. We will help you look forward to your pregnancy and birthing with joy and love, rather than fear and anxiety.

I would not be among you to-night (being awarded the 1964 Nobel Prize in Physiology or Medicine) but for the mentors, colleagues and students who have guided and aided me throughout my scientific life. I wish I could name them all and tell you their contributions. More, however, than anyone else it was the late Rudolf Schoenheimer, a brilliant scholar and a man of infectious enthusiasm, who introduced me to the wonders of Biochemistry. Ever since, I have been happy to have chosen science as my career, and, to borrow a phrase of Jacques Barzun, have felt that 'Science is, in the best and strictest sense, glorious entertainment'.

Creativity—that state when ideas seem to organize themselves into a swift, tightly woven flow, with a feeling of gorgeous clarity and meaning emerging—seems to me physiologically distinctive, and I think that if we had the ability to make fine enough brain images, these would show an unusual and widespread activity with innumerable connections and synchronizations occurring. At such times, when I am writing, thoughts seem to organize themselves in spontaneous succession and to clothe themselves instantly in appropriate words. I feel I can bypass or transcend much of my own personality, my neuroses. It is at once not me and the innermost part of me, certainly the best part of me.

Even in the best of times, when we’re not stressed or needy, many of us enjoy petting our dogs as much as any other aspect of dog ownership. This is not a trivial need. Quiet stroking can significantly change your body’s physiology, lowering your heart rate and blood pressure. It releases endogenous opiates, or internal chemicals that calm and soothe us and play a significant role in good health. Lucky for us, most of our dogs adore being touched. Most normal, well-socialized dogs cherish getting belly rubs and head massages and butt scratches. Many dogs like grooming so much that they’re willing to work for it, pawing or barking whenever needed to remind their human not to stop.

The existence of sensitive people is an advantage for humankind because it is this group that best expresses humanity’s creative urges and needs. Through their instinctual responses the world is best interpreted. Under normal circumstances, they are artists or artisans, seekers, inventors, shamans, poets, prophets. There would be valid and powerful evolutionary reasons for the survival of genetic material coding for sensitivity. It is not diseases that are being inherited but a trait of intrinsic survival value to human beings. Sensitivity is transmuted into suffering and disorders only when the world is unable to heed the exquisitely tuned physiological and psychic responses of the sensitive individual.

Everyone has had the experience of suddenly feeling intense physiological and psychological shifts internally at trading glances with another person; such shifts can be exquisitely pleasurable or unpleasant. How one person gazes at another can alter the other’s electrical brain patterns, as registered by EEGS, and may also cause physiological changes in the body. The newborn is highly susceptible to such influences, with a direct effect on the maturation of brain structures. The effects of maternal moods on the electrical circuitry of the infant’s brain were demonstrated by a study at the University of Washington, Seattle. Positive emotions are associated with increased electrical activity in the left hemisphere. It is known that depression in adults is associated with decreased electrical activity in the circuitry of the left hemisphere. With this in mind, the Seattle study compared the EEGS of two groups of infants: one group whose mothers had symptoms of postpartum depression, the other whose mothers did not. “During playful interactions with the mothers designed to elicit positive emotion,” the researchers reported, “infants of non-depressed mothers showed greater left than right frontal brain activation.” The infants of depressed mothers “failed to show differential hemispheric activation,” meaning that the left-side brain activity one would anticipate from positive, joyful infant-mother exchanges did not occur — despite the mothers’ best efforts. Significantly, these effects were noted only in the frontal areas of the brain, where the centers for the self-regulation of emotion are located. In addition to EEG changes, infants of depressed mothers exhibit decreased activity levels, gaze aversion, less positive emotion and greater irritability. Maternal depression is associated with diminished infant attention spans. Summarizing a number of British studies, Dale F. Hay, a researcher at the University of Cambridge, suggests “that the experience of the mother’s depression in the first months of life may disrupt naturally occurring social processes that entrain and regulate the infant’s developing capacities for attention.

Title IX opened a door fifty years ago that can never be closed again, but equality doesn’t end at the equal right to play. True equality in sports, like any other industry, requires rebuilding the systems so there’s an equal chance to thrive. I’m just one person telling a story to bring an embodied experience of the female athlete to life. I can’t create policy or NCAA best practices, or medical guidelines, but I have some ideas of where to start. We need policies like those created around concussions that specifically protect the health of the female body in sport. We need to create a formal certification to work with female athletes that mandates education on female physiology, puberty, breast development, menstrual health, and the female performance wave.

Decrease Anxiety in an Instant The best way to instantly feel less anxious is to slow your breathing. Try this whenever you feel physically overaroused due to anxiety, or when your thoughts are either racing or frozen. Slowing your breathing will automatically slow down your heart rate. You’ll feel calmer. Since this is a physiological fact, it’s about the only anxiety strategy that has a 100% guarantee of working. The effect is nearly instant. Here are some tips for slowing your breathing 1. Before you try to slow your breathing, drop your shoulders. It’ll make it easier. Also, focus on breathing slowly rather than breathing deeply. 2. If you have an area of tension in your body, like your neck and shoulders are tight, imagine you’re breathing fresh new air into those areas. There’s nothing sciencey about this, but lots of people like this method.

Who would now be in a position to describe that which will one day do away with moral feelings and judgments! -however sure one may be that the foundations of the latter are all defective and their superstructure is beyond repair: their obligatory force must diminish from day to day, so long as the obligatory force of reason does not diminish! To construct anew the laws of life and action – for this task our sciences of physiology, medicine, sociology and solitude are not yet sufficiently sure of themselves: and it is from them that the foundation-stones of new ideals (if not the new ideals themselves) must come. So it is that, according to our taste and talent, we live an existence which is either a prelude or a postlude, and the best we can do in this interregnum is to be as far as possible our own reges and found little experimental states. We are experiments: let us also want to be them!

Who would now be in a position to describe that which will one day do away with moral feelings and judgments! ―however sure one may be that the foundations of the latter are all defective and their superstructure is beyond repair: their obligatory force must diminish from day to day, so long as the obligatory force of reason does not diminish! To construct anew the laws of life and action – for this task our sciences of physiology, medicine, sociology and solitude are not yet sufficiently sure of themselves: and it is from them that the foundation-stones of new ideals (if not the new ideals themselves) must come. So it is that, according to our taste and talent, we live an existence which is either a prelude or a postlude, and the best we can do in this interregnum is to be as far as possible our own reges and found little experimental states. We are experiments: let us also want to be them!

JULIAN HUXLEY’S “EUGENICS MANIFESTO”: “Eugenics Manifesto” was the name given to an article supporting eugenics. The document, which appeared in Nature, September 16, 1939, was a joint statement issued by America’s and Britain’s most prominent biologists, and was widely referred to as the “Eugenics Manifesto.” The manifesto was a response to a request from Science Service, of Washington, D.C. for a reply to the question “How could the world’s population be improved most effectively genetically?” Two of the main signatories and authors were Hermann J. Muller and Julian Huxley. Julian Huxley, as this book documents, was the founding director of UNESCO from the famous Huxley family. Muller was an American geneticist, educator and Nobel laureate best known for his work on the physiological and genetic effects of radiation. Put into the context of the timeline, this document was published 15 years after “Mein Kampf” and a year after the highly publicized violence of Kristallnacht. In other words, there is no way either Muller or Huxley were unaware at the moment of publication of the historical implications of eugenic agendas.

The question concerning the origin of moral valuations is therefore a matter of the highest importance to me because it determines the future of mankind. The demand made upon us to believe that everything is really in the best hands, that a certain book, the Bible, gives us the definite and comforting assurance that there is a Providence that wisely rules the fate of man — when translated back into reality amounts simply to this, namely, the will to stifle the truth which maintains the reverse of all this, which is that hitherto man has been in the worst possible hands, and that he has been governed by the physiologically botched, the men of cunning and burning revengefulness, and the so-called "saints" — those slanderers of the world and traducers of humanity. The definite proof of the fact that the priest (including the priest in disguise, the philosopher) has become master, not only within a certain limited religious community, but everywhere, and that the morality of decadence, the will to nonentity, has become morality per se, is to be found in this: that altruism is now an absolute value, and egoism is regarded with hostility everywhere. He who disagrees with me on this point, I regard as infected. But all the world disagrees with me.

Just as we perceive the outside world on the basis of sensory signals met with a top-down flow of perceptual expectations and predictions, the same applies to perceptions of the internal state of the body. The brain has to know what the internal state of the body is like. It doesn’t have direct access to it, even though both the brain and body happen to be wrapped within a single layer of skin. As with perception of the outside world, all the brain gets from the inside of the body are noisy, ambiguous electrical signals. Therefore it has to bring to bear predictions and expectations in order to make sense of the barrage of sensory signals coming from inside the body, in just the same way as for vision and all the other “classic” senses. And this is what’s collectively called interoception—perception of the body from within. The same computational principles apply. In this view, we can think of emotional conscious experiences, feeling states, in the framework of “interoceptive inference.” So emotions become predictions—“best guesses”—about the hidden causes of interoceptive signals, in the same way that experiences of the outside world are constituted by predictions of the causes of sensory signals. This gives a nice computational and mechanistic gloss to old theories of emotion that originated with William James and Karl Lange—that emotion has to do with perception of physiological change in the body and by the subsequent cognitive “appraisal” of these changes. The predictive-processing view adds to these theories by saying that emotional experience is the joint content of predictions about the causes of interoceptive signals at all levels of abstraction.

Principles That Great Teachers Follow Great teachers know that each brain is unique and uniquely organized. Great teachers know that all brains are not equally good at everything. Great teachers know that the brain is a complex, dynamic system and is changed daily by experiences. Great teachers know that learning is a constructivist process, and that the ability to learn continues through developmental stages as an individual matures. Great teachers know that the search for meaning is innate in human nature. Great teachers know that brains have a high degree of plasticity and develop throughout the lifespan. Great teachers know that MBE science principles apply to all ages. Great teachers know that learning is based in part on the brain’s ability to self-correct. Great teachers know that the search for meaning occurs through pattern recognition. Great teachers know that brains seek novelty. Great teachers know that emotions are critical to detecting patterns, to decision-making, and to learning. Great teachers know that learning is enhanced by challenge and inhibited by threat. Great teachers know that human learning involves both focused attention and peripheral perception. Great teachers know that the brain conceptually processes parts and wholes simultaneously. Great teachers know that the brain depends on interactions with other people to make sense of social situations. Great teachers know that feedback is important to learning. Great teachers know that learning relies on memory and attention. Great teachers know that memory systems differ in input and recall. Great teachers know that the brain remembers best when facts and skills are embedded in natural contexts. Great teachers know that learning involves conscious and unconscious processes. Great teachers know that learning engages the entire physiology (the body influences the brain, and the brain controls the body).

In the words of the master: infinity but without melody. In the second place, with regard to the overthrowing,--this belongs at least in part, to physiology. Let us, in the first place, examine the instruments. A few of them would convince even our intestines (--they _throw open_ doors, as Handel would say), others becharm our very marrow. The _colour of the melody is_ all-important here, _the melody itself_ is of no importance. Let us be precise about _this_ point. To what other purpose should we spend our strength? Let us be characteristic in tone even to the point of foolishness! If by means of tones we allow plenty of scope for guessing, this will be put to the credit of our intellects. Let us irritate nerves, let us strike them dead: let us handle thunder and lightning,--that is what overthrows.{~HORIZONTAL ELLIPSIS~} But what overthrows best, is _passion_.--We must try and be clear concerning this question of passion. Nothing is cheaper than passion! All the virtues of counterpoint may be dispensed with, there is no need to have learnt anything,--but passion is always within our reach! Beauty is difficult: let us beware of beauty!{~HORIZONTAL ELLIPSIS~} And also of _melody!_ However much in earnest we may otherwise be about the ideal, let us slander, my friends, let us slander,--let us slander melody! Nothing is more dangerous than a beautiful melody! Nothing is more certain to ruin taste! My friends, if people again set about loving beautiful melodies, we are lost!{~HORIZONTAL ELLIPSIS~} _First principle_: melody is immoral. _Proof_: "Palestrina". _Application_: "Parsifal." The absence of melody is in itself sanctifying.{~HORIZONTAL ELLIPSIS~} And this is the definition of passion. Passion--or the acrobatic feats of ugliness on the tight-rope of enharmonic--My friends, let us dare to be ugly! Wagner dared it! Let us heave the mud of the most repulsive harmonies undauntedly before us. We must not even spare our hands! Only thus, shall we become _natural_.{~HORIZONTAL ELLIPSIS~}

If we want to sum up the value of the priestly existence in the shortest slogan, we could at once put it like this: the priest is the person who alters the direction of ressentiment. For every suffering person instinctively seeks a cause for his suffering, or, more precisely, an agent, or, even more precisely, a guilty agent sensitive to suffering — in short, he seeks some living person on whom he can, on some pretext or other, unload his feelings, either in fact or in effigy: for the discharge of feelings is the most important way a suffering man seeks relief — that is, some anaesthetic — it’s his involuntarily desired narcotic against any kind of torment. In my view, only here can we find the true physiological cause of ressentiment, revenge, and things related to them, in a longing for some anaesthetic against pain through one’s emotions. People usually look for this cause, most incorrectly, in my opinion, in the defensive striking back, a merely reactive protective measure, a “reflex movement” in the event of some sudden damage and threat, of the sort a decapitated frog still makes in order to get rid of corrosive acid. But the difference is fundamental: in one case, people want to prevent suffering further damage; in the other case, people want to deaden a tormenting, secret pain which is becoming unendurable by means of a more violent emotion of some kind and, for the moment at least, to drive it from their consciousness — for that they need some emotion, as unruly an emotion as possible, and, in order to stimulate that, they need the best pretext available. “Someone or other must be guilty of the fact that I am ill” — this sort of conclusion is characteristic of all sick people, all the more so if the real cause of their sense that they are sick, the physiological cause, remains hidden (—it can lie, for example, in an illness of the nervus sympathicus [sympathetic nerve], or in an excessive secretion of gall, or in a lack of potassium sulphate and phosphate in the blood, or in some pressure in the lower abdomen, which blocks the circulation, or in a degeneration of the ovaries, and so on).

Rape has been described by victim advocate and former police officer Tom Tremblay as “the most violent crime a person can survive.”10 Those who have not been sexually assaulted can perhaps most clearly understand the experience of a survivor by thinking of them as having survived an attempted murder that used sex as the weapon. Sexual violence often doesn’t look like what we think of as “violence”—only rarely is there a gun or knife; often there isn’t even “aggression” as we typically think of it. There is coercion and the removal of the targeted person’s choice about what will happen next. Survivors don’t “fight” because the threat is too immediate and inescapable; their bodies choose “freeze” because it’s the stress response that maximizes the chances of staying alive . . . or of dying without pain. Trauma isn’t always caused by one specific incident. It can also emerge in response to persistent distress or ongoing abuse, like a relationship where sex is unwanted, though it may be technically “consensual” because the targeted person says yes in order to avoid being hurt or feels trapped in the relationship or is otherwise coerced. In that context, a survivor’s body gradually learns that it can’t escape and it can’t fight; freeze becomes the default stress response because of the learned pattern of shutdown as the best way to guarantee survival. Each person’s experience of survival is unique, but it often includes a kind of disengaged unreality. And afterward, that illusion of unreality gradually degrades, disintegrating under the weight of physical existence and burdened memory. The tentative recognition that this thing has actually happened incrementally unlocks the panic and rage that couldn’t find their way to the surface before, buried as they were under the overmastering mandate to survive. But survival is not recovery; survival happens automatically, sometimes even against the survivor’s will. Recovery requires an environment of relative security and the ability to separate the physiology of freeze from the experience of fear, so that the panic and the rage can discharge, completing their cycles at last.

We are urged by Socrates to be temperate, and as healers we can sometimes do the best for our patients by doing the least. As physicians, we become true practitioners of the healing art when we recognize the potential for illness and disease to improve naturally with time and overcome the urge to provide unnecessary physiological therapy.

like to make practices stimulating, fun, and, most of all, efficient. Coach Al McGuire once told me that his secret was not wasting anybody’s time. “If you can’t it get done in eight hours a day,” he said, “it’s not worth doing.” That’s been my philosophy ever since. Much of my thinking on this subject was influenced by the work of Abraham Maslow, one of the founders of humanistic psychology who is best known for his theory of the hierarchy of needs. Maslow believed that the highest human need is to achieve “self-actualization,” which he defined as “the full use and exploitation of one’s talents, capacities and potentialities.” The basic characteristics of self-actualizers, he discovered in his research, are spontaneity and naturalness, a greater acceptance of themselves and others, high levels of creativity, and a strong focus on problem solving rather than ego gratification. To achieve self-actualization, he concluded, you first need to satisfy a series of more basic needs, each building upon the other to form what is commonly referred to as Maslow’s pyramid. The bottom layer is made up of physiological urges (hunger, sleep, sex); followed by safety concerns (stability, order); love (belonging); self-esteem (self-respect, recognition); and finally self-actualization. Maslow concluded that most people fail to reach self-actualization because they get stuck somewhere lower on the pyramid. In his book The Farther Reaches of Human Nature, Maslow describes the key steps to attaining self-actualization: experiencing life “vividly, selflessly, with full concentration and total absorption”; making choices from moment to moment that foster growth rather than fear; becoming more attuned to your inner nature and acting in concert with who you are; being honest with yourself and taking responsibility for what you say and do instead of playing games or posing; identifying your ego defenses and finding the courage to give them up; developing the ability to determine your own destiny and daring to be different and non-conformist; creating an ongoing process for reaching your potential and doing the work needed to realize your vision. fostering the conditions for having peak experiences, or what Maslow calls “moments of ecstasy” in which we think, act, and feel more clearly and are more loving and accepting of others.

The best explanation for India’s shortage of fast bowlers is not religious or physiological: India has 30 million Punjabis of its own and an awful lot of tall people. It is cultural. India’s biggest cricketing heroes have been batsmen, from Nayudu to Gavaskar and Tendulkar. Some see in this a continuation of the old British snobbery favouring gentleman-batsmen over working-class bowlers.

another person’s behalf? Aren’t you also thankful that others have summoned Him on yours? Our homes today are threatened by fevers of all sorts—far beyond the physiological: unresolved conflict, unforgiveness, unfaithfulness, compromising media communications, pornography, and more. We need Jesus in our homes. Do you have a sense of Christ’s activity in your home? I’ve a good reason for asking you this question. Almost every spiritual marker of Christ’s heightened activity in my home came as a direct result of some threatening situation. Right now both my daughters are walking with God, but I assure you this did not simply happen in the natural evolution of their lives. I’ve watched their relationships grow through situations in which some threat convinced them to cleave closer to Christ. God is so faithful. He can use the worst of circumstances to introduce us to the best of relationships. I am intrigued by the fact that Simon’s mother-in-law immediately began serving Christ and the others. Few people are more compelled to serve than those who have experienced the healing power of Christ.

people, the language you use to communicate with others. Your mental focus and your physiology together instantly put you into a particular state or emotion. Physiology absolutely matters. Exercising, or better yet, implementing a complete fitness program (in other words a regimen that safely works both your cardio and muscles—even yoga!) increases the effective use of oxygen and gets rid of waste throughout your brain and body, and helps soothe your soul. Emotional states of mind, which range from the worst (a suicidal state) to the best (a peak or flow state), are powerful. Your state drives actions, decisions, and even indecision, and is the direct predictor of results somewhere between the lowest

to highest in quality. Your results subsequently affect your beliefs, and at times, even change those beliefs, if not your own story in your head. The lesson here, if not a critical success factor, is to consciously and continuously strengthen the quality of your belief system, inner voice, and physiology, empowering your mind and body and stretching their thresholds and tolerance for obstacles and making way for creative thoughts. Doing so means you will spend and enjoy a lot more time in productive and positive states, and increasingly more time in high-performance or flow states, producing more positive outcomes. The best state is a peak or flow state. Have you noticed how easy it is for champion

pleasure is just as often a function of our emotional associations as it is of our physical sensations — and for this reason, there can be psychology as well as physiology at play when it comes to pairing beverages with food.

Your natural tools are your thoughts, physiological responses, body movements, voice, and senses. They determine how you handle pressure, regardless of your level of expertise, abilities, or good intentions. People

The best way to head off these headaches is to stay hydrated and eat more nitric oxide (NO)–rich foods, such as beets, pomegranate, watermelon, and spinach in the days leading up to the start of your period.

The fact that insulin increases the formation of fat has been obvious ever since the first emaciated dog or diabetic patient demonstrated a fine pad of adipose tissue, made as a result of treatment with the hormone. REGINALD HAIST AND CHARLES BEST, The Physiological Basis of Medical Practice, 1966

Not only had the happy films made them feel better, but they had undone the physiological effects of stress. In other words, a quick burst of positive emotions doesn’t just broaden our cognitive capacity; it also provides a quick and powerful antidote to stress and anxiety, which in turn improves our focus and our ability to function at our best level.

The best carb sources are those that are richer in glucose, because they shoot straight into your system. Starchy veggies such as white potatoes, peas, corn, winter squash, and root veggies such as parsnips are not only richer in nutrients, but they also provide greater amounts of carbohydrate overall.

For the purposes of this book, your “buttons” are your nervous system and a “trigger” is anything that revs up your nervous system and makes your buttons bigger, brighter, more sensitive, and way easier for your kids to push. And your children will push your buttons. They are genetically, evolutionarily, physiologically, developmentally, relationally, psychologically, and emotionally wired to jam their sticky little fingers into your buttons every chance they get. Some kids push harder and faster than other kids, but they all push. It doesn’t mean they secretly despise you. It just means they’re your kids. Many parenting books focus on how to get kids to stop with all the pushing already. While it is technically your job as a parent to teach your children to keep their hands to themselves, both literally and figuratively, this is not the best tactic for managing your shit. Do you really want to hinge your sanity on the behavior of someone who licks walls and melts down over the shape of a piece of toast? Yeah, I didn’t think so.

THERMOGRAPHY Misinformation abounds as to the true nature of breast cancer and what causes it. With so much public focus on breast cancer awareness, very little attention is given to breast health, which we know is governed by things like clean eating, routine detoxification, energy balance, and stress reduction, among other things. These other things include not blasting radiation at the breasts in the form of mammograms, which only exacerbate breast cancer risk. Dr. Martin Bales, L.Ac., D.A.O.M., a licensed acupuncturist and certified thermologist at the Center for New Medicine in Irvine, California, has for years been administering one of the best-known alternatives to mammograms: thermograms. As its name suggests, thermography utilizes the power of infrared heat—hence the root word “therm”—to detect physiological abnormalities indicative of a possible breast cancer diagnosis. Dr. Bales’s father first pioneered the technology in the late 1970s with the development of the world’s first all-digital infrared camera, which was used for missile detection purposes during wartime. Its capacity to track the heat signature of missiles was applied to the field of medicine in the 1980s, which eventually gave way to thermographic medical devices. Dr. Bales opined during a recent interview: “In the early eighties, a group of doctors approached my father and said, ‘You know, we’ve heard the body—obviously with its (blood) circulation—we can diagnose a lot of diseases by seeing where there’s hot spots and where there’s cold.’ He said, ‘Okay, I’ll make a medical version for you.’” And the rest is history: thermography machines that identify hot spots in the breasts later hit the market, and select doctors and clinics offer it as a safe, side effect–free alternative to mammograms. “The most promising aspect of thermography is its ability to spot anomalies years before mammography,” says women’s health expert Christiane Northrup, M.D., about the merits of thermography. “With thermography as your regular screening tool, it’s likely that you would have the opportunity to make adjustments to your diet, beliefs, and lifestyle to transform your cells before they became cancerous. Talk about true prevention.

Thanks to the trial and error of evolution, almost every detail about our physiology is there for a reason. Mother Nature did not provide us with highly tuned taste buds simply so we could enjoy a fine glass of wine from the Staglin Family Vineyard or savor every bite of a pork bun from Momofuku Ssäm Bar. Our taste buds tell our digestive systems which enzymes to release to best deal with the food that is on its way down, just like our sense of smell helps us detect if food is spoiled or not. Similarly our eyebrows were designed to help channel sweat away from our eyes when we were running toward prey—or running away to avoid becoming prey. Everything about our bodies was designed with one goal—to help us survive. This includes the feelings of happiness.

4. The Third Step in the Mental Training. To be the lord of mind is more essential to Enlightenment, which, in a sense, is the clearing away of illusions, the putting out of mean desires and passions, and the awakening of the innermost wisdom. He alone can attain to real happiness who has perfect control over his passions tending to disturb the equilibrium of his mind. Such passions as anger, hatred, jealousy, sorrow, worry, grudge, and fear always untune one's mood and break the harmony of one's mind. They poison one's body, not in a figurative, but in a literal sense of the word. Obnoxious passions once aroused never fail to bring about the physiological change in the nerves, in the organs, and eventually in the whole constitution, and leave those injurious impressions that make one more liable to passions of similar nature. We do not mean, however, that we ought to be cold and passionless, as the most ancient Hinayanists were used to be. Such an attitude has been blamed by Zen masters. "What is the best way of living for us monks?" asked a monk to Yun Ku (Un-go), who replied: "You had better live among mountains." Then the monk bowed politely to the teacher, who questioned: "How did you understand me?" "Monks, as I understood," answered the man, "ought to keep their hearts as immovable as mountains, not being moved either by good or by evil, either by birth or by death, either by prosperity or by adversity." Hereupon Yun Ku struck the monk with his stick and said: "You forsake the Way of the old sages, and will bring my followers to perdition!" Then, turning to another monk, inquired: "How did you understand me?" "Monks, as I understand," replied the man, "ought to shut their eyes to attractive sights and close their ears to musical notes." "You, too," exclaimed Yun Ka, "forsake the Way of the old sages, and will bring my followers to perdition!" An old woman, to quote another example repeatedly told by Zen masters, used to give food and clothing to a monk for a score of years. One day she instructed a young girl to embrace and ask him: "How do you feel now?" "A lifeless tree," replied the monk coolly, "stands on cold rock. There is no warmth, as if in the coldest season of the year." The matron, being told of this, observed: "Oh that I have made offerings to such a vulgar fellow for twenty years!" She forced the monk to leave the temple and reduced it to ashes.[FN#238]

Imagine if you met someone sitting at a train station who told everyone how great it is to go West. ‘West is the way of the future,’ he says, ‘we should all keep moving in that direction.’ A year later you pass the same station and the same guy is there, in the exact same spot, still telling everyone they should go West. ‘You need to move West to achieve a meaningful life,’ he proclaims, ‘it is the path to happiness and satisfaction.’ A year later you pass the same station and the guy is still there. Right there. He hasn’t moved one inch in a westerly direction. This time you stop and ask him why he is such a big fan of going West, and he tells you about all the things he has read about the direction West, recommends some useful websites, and even shows you some pictures he has cut out of pamphlets, depicting things you will see if you go West. You ask him what is the best thing he has ever seen while travelling West, and he shakes his head. ‘I’ve never been any more West than here, too many bumps along the way. I’m waiting for them to fix up the track so it will be a smoother journey,’ he tells you. ‘But,’ he adds proudly, ‘I haven’t moved even one inch East in the past few years.’ How seriously would you take that man’s advice to go West? If West is the way to go, maybe it’s worth travelling over some bumps to make progress in that direction? Values are like compass directions. They’re meaningless unless you move. Saying that you really like going West doesn’t mean a whole lot if you don’t take at least a small step in that direction. That doesn’t mean it’s always going to be easy to move West or that you can move miles in that direction every day. Some days it feels like there are things pulling you in every direction or stopping you from moving at all. The blocks might be thoughts, feelings, memories, physiological sensations or other people and their rules. But it’s still worthwhile to move in the directions you care about even if sometimes you are only able to take tiny steps. (Stuff that Sucks, p 50)

Metabolic networks remain the only class of biological network reconstructed reasonably comprehensively at the genome-scale in humans. Given that metabolic networks are ultimately based on directed chemical reactions that obey the laws of mass and energy balance, they can further serve the basis for calculations to predict reaction rates (metabolic flux). These fluxes can subsequently be used to compute productions and growth rates of metabolites. In flux balance analysis, the set of reactions is formulated as a stochiometric matrix, which enumerates the ratios of metabolite participation in each reaction. A set of physically possible reaction flux rates result by enforcing a steady-state mass balance (homeostasis) and additional constraints on reaction reversabilities and maximal conversion rates. From within the space of chemically feasible reaction flux combinations, the subset of biologically relevant reaction flux profiles can be solved by optimizing an objective function. The most commonly used objective function in microbes has been to maximize the production of biomass, which serves as a proxy for maximizing growth rate. Notably, while maximal growth may be an appropriate assumption for diseases such as cancer under certain conditions, the best cellular objective function to simulate many human tissues and cell types is unknown (and is likely condition-specific). Adjusting this objective function, which was developed based on microbial physiology, to better reflect human tissues is an area of active research.

Discussion Questions 1. Have you ever lost someone you care about to serious illness? What is the best way to empathize and comfort those facing serious, life-threatening illness? How prepared do you feel to do and say the right thing when that time comes for someone in your life? 2. What do you think the author means when he says that we’ve “medicalized” mortality? Do you agree? Why do you think that has happened in our culture? How can we shift to a more humane, compassionate approach to mortality? 3. Have you ever seen anyone die or been with someone in the final stages of life? Can you describe that experience? How did the experience affect your wishes for the end of your own life? 4. What did you discover about the physiology of aging? What is your attitude toward aging?

In a series of studies, Julia Lee, a professor at the University of Michigan, found that those who undergo relational best-self activation experience stronger immune responses, enhanced creative problem solving (over 200 percent improvement), and significantly less anxiety and negative physiological arousal.

The very best meditators seem even to be able to suppress their startle response, a rudimentary physiological reaction to loud noises or other sudden stimuli that is mediated through the amygdala. (The strength of one’s startle response—whether measured in infancy or adulthood—has been shown to be highly correlated with the propensity to develop anxiety disorders and depression.)

But if we accept that the aim of any activity is merely our own pleasure, and define it merely by that pleasure, then this definition will obviously be false. That is what has happened with the definition of art. For, in analysing the question of food, it would not occur to anyone to see the significance of food in the pleasure we derive from eating it. Everyone understands that the satisfaction of our taste can in no way serve as a basis for defining the merits of food, and that we therefore have no right to suppose that dinners with cayenne pepper, Limburger cheese, alcohol and so on, to which we are accustomed and which we like, represent the best human food. In just the same way, beauty, or that which pleases us, can in no way serve as the basis for defining art, and a series of objects that give us pleasure can in no way be an example of what art should be. To see the aim and purpose of art in the pleasure we derive from it is the same as to ascribe the aim and significance of food to the pleasure we derive from eating it, as is done by people who stand at the lowest level of moral development (savages, for instance). Just as people who think that the aim and purpose of food is pleasure cannot perceive the true meaning of eating, so people who think that the aim of art is pleasure cannot know its meaning and purpose, because they ascribe to an activity which has meaning in connection with other phenomena of life the false and exclusive aim of pleasure. People understand that the meaning of eating is the nourishment of the body only when they cease to consider pleasure the aim of this activity. So it is with art. People will understand the meaning of art only when they cease to regard beauty – that is, pleasure – as the aim of this activity. To recognize beauty, or the certain kind of pleasure to be derived from art, as the aim of art, not only does not contribute to defining what art is, but, on the contrary, by transferring the question to a realm quite alien to art – to metaphysical, psychological, physiological, and even historical discussions of why such-and-such a work is pleasing to some, and such-and-such is not pleasing, or is pleasing to others – makes that definition impossible. And just as discussing why one person likes pears and another meat in no way helps to define what the essence of nourishment is, so, too, the resolution of questions of taste in art (to which all discussions of art involuntarily come down) not only does not contribute to understanding what makes up that particular human activity which we call art, but makes that understanding completely impossible.

You must learn bow to handle rejection. When I repeat that in a seminar, I can feel the physiology in the room change. Is there anything in the human language with more sting than the tiny word “no”? If you’re in sales, what’s the difference between making $100,000 and making $25,000? The main difference is learning how to handle rejection so that this fear no longer stops you from taking action. The best salesmen are those who are rejected the most. They’re the ones who can take any “no” and use it as a prod to go onto the next “yes.

Stuck on "on": how to manage a Sympathetic response 1. Say to yourself, "I am having trauma response. This is a physiological process. I'm not crazy." 2. Make a list of people, places, and things that you love. Notice how your body feels as you think about hugging your best friend, sitting on a beach, or curling up with your favorite book. 3. Use your senses. Weighted blankets. Essential oils. Soft music. Warm tea. These can all help your nervous system come back down. 4. Count backward from the number 31. 5. Notice 5 things you can see, 4 things you can hear, 3 things you can touch, and 1 thing you can taste. 6. Push as hard as you can against a door or a wall. Notice your muscles firing. Step back, take a break. Repeat three times. 7. Do simple math problems in your head. Simple thinking tasks will help your brain reorientate itself. 8. Name the sensations inside your body. Say to yourself out loud, "I feel tension in my neck. I feel tightness in my stomach. I feel he at in my face." Then look for one place in your body where you feel neutral or calm. Most people can access neutral by noticing random areas like their left knee cap or right ring finger. Focus your attention first on the neutral area, then on the tense area, then on the neutral area. Do this for four minutes. 9. Don't ask why you feel panic. Do ask who or what will help you feel safe. 10. If you have a dog or a cat, gently put your hand on their heart and count their heartbeat for three minutes. Stuck on "off": how to manage a high tone dorsal vagal state. 1. Remind yourself that you are not lazy or unmotivated. Tell yourself, "I am having a trauma response. This is a thing. I am not crazy." 2. Get cold. Splash ice-cold water on your face. Hold ice cubes in your hand. Put an ice pack on your neck. Or jump into the coldest possible shower you can stand. 3. Hum or sing. There's a reason people have changed "Ommm" since the 6th century. 4. Social connection is powerful medicine. Connect with a human over the phone: good. Over video chat: better: In person: best. 5. Don't ask why you're feeling frozen. Do ask who or what might help you feel safer. 6. Don't use hyperbolic exaggerated language like "I feel buried" or "I'm drowning." This language reinforces the stress response. Instead, get really specific." I need to call my son's teacher, pick up my prescription and finish a proposal for work." Write down the specific tasks. This will help your brain click back into solution mode. 7. Suck on a lemon. This sounds weird, but it can help suck your brain out of shutdown mode. 8. Open and close your mouth. Then move your head. Then stretch your arms and legs. 9. Grab both ends of a blanket and wring it out as you would if it was soaking wet. Notice your muscles firing as you do this. Take a break. Repeat three times. 10. If you have a safe and willing friend or partner, make eye contact with them for 2-3 minutes. It's super awkward, but you will get a bonus dose of energy if you both end up laughing.

William James said near the end of the nineteenth century, “No mental modification ever occurs which is not accompanied or followed by a bodily change.” A hundred years later, Norman Cousins summarized the modern view of mind-body interactions with the succinct phrase “Belief becomes biology.”6 That is, an external suggestion can become an internal expectation, and that internal expectation can manifest in the physical body. While the general idea of mind-body connections is now widely accepted, forty years ago it was considered dangerously heretical nonsense. The change in opinion came about largely because of hundreds of studies of the placebo effect, psychosomatic illness, psychoneuroimmunology, and the spontaneous remission of serious disease.7 In studies of drug tests and disease treatments, the placebo response has been estimated to account for between 20 to 40 percent of positive responses. The implication is that the body’s hard, physical reality can be significantly modified by the more evanescent reality of the mind.8 Evidence supporting this implication can be found in many domains. For example: • Hypnotherapy has been used successfully to treat intractable cases of breast cancer pain, migraine headache, arthritis, hypertension, warts, epilepsy, neurodermatitis, and many other physical conditions.9 People’s expectations about drinking can be more potent predictors of behavior than the pharmacological impact of alcohol.10 If they think they are drinking alcohol and expect to get drunk, they will in fact get drunk even if they drink a placebo. Fighter pilots are treated specially to give them the sense that they truly have the “right stuff.” They receive the best training, the best weapons systems, the best perquisites, and the best aircraft. One consequence is that, unlike other soldiers, they rarely suffer from nervous breakdowns or post-traumatic stress syndrome even after many episodes of deadly combat.11 Studies of how doctors and nurses interact with patients in hospitals indicate that health-care teams may speed death in a patient by simply diagnosing a terminal illness and then letting the patient know.12 People who believe that they are engaged in biofeedback training are more likely to report peak experiences than people who are not led to believe this.13 Different personalities within a given individual can display distinctly different physiological states, including measurable differences in autonomic-nervous-system functioning, visual acuity, spontaneous brain waves, and brainware-evoked potentials.14 While the idea that the mind can affect the physical body is becoming more acceptable, it is also true that the mechanisms underlying this link are still a complete mystery. Besides not understanding the biochemical and neural correlates of “mental intention,” we have almost no idea about the limits of mental influence. In particular, if the mind interacts not only with its own body but also with distant physical systems, as we’ve seen in the previous chapter, then there should be evidence for what we will call “distant mental interactions” with living organisms.

Psychologists offer two additional points of interest for those adopting the strategy of reappraisal. The first is that reappraisal works best for those who are interoceptively aware: we have to be able to identify our internal sensations, after all, before we can begin to modify the way we think about them. Second, the sensations we’re actually feeling have to be congruent with the emotion we’re aiming to construct. We’re able to reappraise nervousness as excitement because the physiological cues associated with the two emotions are so similar; if what we’re feeling is a heavy sense of apathy or lassitude, exclaiming “I’m so excited!” isn’t going to work.

Osip Mandelstam in the context of early twentieth-century Russia, his wife Nadezhda writes, “The poet’s mode of thought is the product of all sides of his personality: the intellectual, physiological, spiritual, and emotional, a synthesis of what he perceives through his senses, his instincts and desires, and the higher aspirations of his spirit. All these can be bound together only by some dominant idea which shapes the personality. If there is no such idea, one will have, at best, a clever craftsman, a ‘translator of ready-made ideas,’ a mechanical nightingale. The unifying idea can be located at any level of the personality—in its deep reaches or on the surface.

Fifty percent of polled athletes in a 2014 ESPN The Magazine survey reported that menstrual cramps affected their game at some point. The best way to mitigate this is to do some preplanning. In the 5 to 7 days before your period starts, you can reduce the effect of cramp-causing chemicals (specifically PE-2, an estrogen-mediated prostaglandin) by taking magnesium, omega-3 fatty acids, and low-dose 80-milligram aspirin. Yes, it has to be aspirin, not ibuprofen or another nonsteroidal anti-inflammatory drug (NSAID), because aspirin suppresses the production of prostaglandins irreversibly, whereas other NSAIDs are reversible. Headaches

physiologic birth, which the American College of Nurse-Midwives describes as birth “that is powered by the innate human capacity of the woman and fetus.

fear inhibits learning. Research shows that fear consumes physiologic resources, diverting them from parts of the brain that manage working memory and process new information. In a word, learning. And that includes learning from failure. It is hard for people to do their best work when they’re afraid. It’s especially hard to learn from failure because doing so is a cognitively demanding task.

Stress is a demand on the organism that is beyond the capacity of the organism to deal with. And it has elements of uncertainty, lack of information and loss of control and connection. The more isolated you are, the more stressed you are. Now, in our society, because of our breakdown of community structures, clan, family, extended family.. people are more isolated and the demands are also greater, both parents having to work now to provide living for the family. Parents are distracted by anxiety about economic conditions, they have less support because relationships are more difficult, marriages are very stressed (there's a fairly high divorce rate) and a lot of marriages even without divorce are under strain. And all this makes for a lot of emotional stress on the part of the parents, which gets translated to the kids. Not because the parents are not doing their best, not because the parents are not dedicated or devoted, but because they are stressed. A whole number of studies have shown that parents who are stressed, their children are more likely to have asthma. In other words, the child's lung function is actually affected by the emotional stress on the parent and it's physiologically very straightforward. The child is very plugged into the parent, emotionally and even biologically and whatever stresses the parent will stress the child.

Fear inhibits learning. Research in neuroscience shows that fear consumes physiologic resources, diverting them from parts of the brain that manage working memory and process new information. This impairs analytic thinking, creative insight, and problem solving.15 This is why it's hard for people to do their best work when they are afraid.

Everything you do (or don’t do) affects you both psychologically and physiologically. Every suit you wear, every book you read, every movie you watch is either edifying or eroding your ability to develop into the guy you want to be, the guy you know you can be—the guy who is the best version of you.

Physiology at MIT recognized that the richness and detail of the collected data opened the feasibility of creating a new generation of monitoring systems to track the physiologic state of the patient, employing the power of modern signal processing, pattern recognition, computational modeling, and knowledge-based clinical reasoning. In the long term, we hoped to design monitoring systems that not only synthesized and reported all relevant measurements to clinicians, but also formed pathophysiologic hypotheses that best explained the observed data. Such systems would permit early detection of complex problems, provide useful guidance on therapeutic interventions, and ultimately lead to improved patient outcomes.

Resplendent in the Sunday best of human rights and free will, our tapeworm-citizens flatter themselves with having driven out ‘barbarism’, with having finally attained the ideal of the weak, the slave morality of which Nietzsche says that it ‘first has to have an opposing, external world, it needs, physiologically speaking, external stimuli in order to act at all,—its action is basically a reaction’.

What turned heads was the finding from the blood samples. Participants scoring high on the hedonic scale were far more likely to have inflammatory gene expression and decreased expression of genes involved in antibody and antiviral response, whereas participants scoring high on the eudaimonic scale had the opposite pattern of expression. In other words, participants with greater eudaimonia were physiologically healthier. As the researchers state, “Hedonic and eudaimonic well-being were originally distinguished to resolve basic and ancient philosophical questions regarding the best way for humans to live. The present data offer little grounds to prefer one mode of happiness over the other based on affective experience, but they identify a stark contrast at the level of molecular physiology.” But before we assume that Angelina Jolie will live to be 140 and Paris Hilton will explode in a giant ball of pus, we should do what scientists like to do when something as radical as this is found: more research.

The molecular basis of memory and learning, the discovery of which earned Kandel a share of the 2000 Nobel Prize in physiology or medicine, stands as one of the best understood of the changes the brain undergoes. It is one of the mechanisms that underlie the plasticity of the developing brain. Changes in how an organism interacts with its environment result in changes in connectivity.

Just as we do physiologically, emotional toxicity is best released daily. We have to regularly release old feelings and disturbing thoughts that are holding us back.” --Dr. Anne Redelfs

Mark, at dinner, said he’d been re-reading “Anna Karenina”. Found it good, as novels go. But complained of the profound untruthfulness of even the best imaginative literature. And he began to catalogue its omissions. Almost total neglect of those small physiological events that decide whether day-to-day living shall have a pleasant or unpleasant tone. Excretion, for example, with its power to make or mar the day. Digestion. And, for the heroines of novel and drama, menstruation. Then the small illnesses—catarrh, rheumatism, headache, eyestrain. The chronic physical disabilities—ramifying out (as in the case of deformity or impotence) into luxuriant insanities. And conversely the sudden accessions, from unknown visceral and muscular sources, of more than ordinary health. No mention, next, of the part played by mere sensations in producing happiness. Hot bath, for example, taste of bacon, feel of fur, smell of freesias. In life, an empty cigarette-case may cause more distress than the absence of a lover; never in books. Almost equally complete omission of the small distractions that fill the greater part of human lives. Reading the papers; looking into shops; exchanging gossip; with all the varieties of day-dreaming, from lying in bed, imagining what one would do if one had the right lover, income, face, social position, to sitting at the picture palace passively accepting ready-made day-dreams from Hollywood Lying by omission turns inevitably into positive lying. The implications of literature are that human beings are controlled, if not by reason, at least by comprehensible, well-organized, avowable sentiments. Whereas the facts are quite different. Sometimes the sentiments come in, sometimes they don’t. All for love, or the world well lost; but love may be the title of nobility given to an inordinate liking for a particular person’s smell or texture, a lunatic desire for the repetition of a sensation produced by some particular dexterity. Or consider those cases (seldom published, but how numerous, as anyone in a position to know can tell!), those cases of the eminent statesmen, churchmen, lawyers, captains of industry—seemingly so sane, demonstrably so intelligent, publicly so high-principled; but, in private, under irresistible compulsion towards brandy, towards young men, towards little girls in trains, towards exhibitionism, towards gambling or hoarding, towards bullying, towards being whipped, towards all the innumerable, crazy perversions of the lust for money and power and position on the one hand, for sexual pleasure on the other. Mere tics and tropisms, lunatic and unavowable cravings—these play as much part in human life as the organized and recognized sentiments. And imaginative literature suppresses the fact. Propagates an enormous lie about the nature of men and women.

Mark, at dinner, said he’d been re-reading “Anna Karenina”. Found it good, as novels go. But complained of the profound untruthfulness of even the best imaginative literature. And he began to catalogue its omissions. Almost total neglect of those small physiological events that decide whether day-to-day living shall have a pleasant or unpleasant tone. Excretion, for example, with its power to make or mar the day. Digestion. And, for the heroines of novel and drama, menstruation. Then the small illnesses—catarrh, rheumatism, headache, eyestrain. The chronic physical disabilities—ramifying out (as in the case of deformity or impotence) into luxuriant insanities. And conversely the sudden accessions, from unknown visceral and muscular sources, of more than ordinary health. No mention, next, of the part played by mere sensations in producing happiness. Hot bath, for example, taste of bacon, feel of fur, smell of freesias. In life, an empty cigarette-case may cause more distress than the absence of a lover; never in books. Almost equally complete omission of the small distractions that fill the greater part of human lives. Reading the papers; looking into shops; exchanging gossip; with all the varieties of day-dreaming, from lying in bed, imagining what one would do if one had the right lover, income, face, social position, to sitting at the picture palace passively accepting ready-made day-dreams from Hollywood.