Pans Lab Quotes

Washington University found that adding a single extra gene dramatically boosted a mouse’s memory and ability. These “smart mice” could navigate mazes faster, remember events better, and outperform other mice in a wide variety of tests. They were dubbed “Doogie mice,” after the precocious character on the TV show Doogie Howser, M.D. Dr. Tsien began by analyzing the gene NR2B, which acts like a switch controlling the brain’s ability to associate one event with another. (Scientists know this because when the gene is silenced or rendered inactive, mice lose this ability.) All learning depends on NR2B, because it controls the communication between memory cells of the hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, and they showed impaired memory and learning disabilities. Then he created a strain of mice that had more copies of NR2B than normal, and found that the new mice had superior mental capabilities. Placed in a shallow pan of water and forced to swim, normal mice would swim randomly about. They had forgotten from just a few days before that there was a hidden underwater platform. The smart mice, however, went straight to the hidden platform on the first try. Since then, researchers have been able to confirm these results in other labs and create even smarter strains of mice. In 2009, Dr. Tsien published a paper announcing yet another strain of smart mice, dubbed “Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was able to remember novel facts (such as the location of toys) three times longer than the genetically modified strain of mouse previously thought to be the smartest. “This adds to the notion that NR2B is a universal switch for memory formation,” remarked Dr. Tsien. “It’s like taking Michael Jordon and making him a super Michael Jordan,” said graduate student Deheng Wang. There are limits, however, even to this new mice strain. When these mice were given a choice to take a left or right turn to get a chocolate reward, Hobbie-J was able to remember the correct path for much longer than the normal mice, but after five minutes he, too, forgot. “We can never turn it into a mathematician. They are rats, after all,” says Dr. Tsien. It should also be pointed out that some of the strains of smart mice were exceptionally timid compared to normal mice. Some suspect that, if your memory becomes too great, you also remember all the failures and hurts as well, perhaps making you hesitant. So there is also a potential downside to remembering too much.

Laminated, or tri-ply, pans offer the best of both worlds. Generally, they are constructed with a layer of aluminum sandwiched between two layers of stainless steel. They have the high density of a stainless steel pan, with the great conductivity of aluminum, making them the pan of choice for most home cooks (including me!).

Creation Myth I'm the great-grandson of a sheep farmer, child of sumacs, trash trees shedding their ancient scales. I'm drawn from fair grass on the north end, my molecules spat from coal and cattle, the Indiana dusk. I'm notes scrawled on freezer paper, the one looped oven mitt Aunt Bev crocheted while the baby lay feverish in its crib. I rise from a day gone thin as Cousin Ceily, who wore her cancer wigs to church. I come from boys unfastening in the 4-H bathroom, the stink of urinal cakes, dirty hands that scratched an itch. I breathe in arc welders and air compressors. I breathe out milk leaking from nurse cows, Uncle Jake's spoiled old bitches. I'm run through with moths and meth labs, a child of the KKK, men who lynched Tom Shipp from a split oak in Marion, August 1930. My cells carry his shadow swaying over uncut grass. They carry my second third cousin cheering in the back. I rise from aphids in honeysuckle, egg yolks flecked with blood. Born one humid summer night, my body hums like a black cricket, transmitting August across the fields. I sing till my throat bleeds. I smoke like a pan of scorched sugar. I'll never forget the miracle of firecrackers, freezer meat, murky gray lemonade. I'm born to thunder in the veins, a child of form, a rusted gasket ring, some disenchanted thing, the promise of a worm.

Apart from IBM, companies approached included Hilton Hotels, Parker Pens, Pan American World Airlines, Hewlett-Packard, Bell Labs, Armstrong Cork, Seabrook Farms, Bausch & Lomb, and Whirlpool. The number of firms consulted ultimately topped forty.

It is her mother’s exhausted face leaning over the crib, relieved the colicky screams have stopped at last, such a good girl, both of them happy now as she sucks her sugar water, swallows, sucks, gulps. It is her hopscotch-scraped knee with its grid of blood, her little girl tears, the kiss-it-better not working and so the butterscotch candies uncellophaned fast from grandma’s purse, it is the sticky butter-sweet glowing her blood, and all is fine now, all is good. It is the big girl finishing her glass of milk and so the reward of Whoppers Malted Milk Balls mumping her cheeks, smiles all around. It is look she’s finished her homework cleaned her room eaten her glazed carrots at dinner, and so now the nipple’d sweet of a Hershey’s Kiss poking out her cheek, the tiny crunch of M&M’s candy coatings, and how long can she hold the creamy brown melt in her mouth. It is the Halloween bounty, the season of candy corn and Tootsie Pops, the gritty sweet sand of Pixy Stix, the plastic orange pumpkin weighted with mini Mounds and Snickers and Milky Ways and Baby Ruths, all careful-parent examined for razor blades, for evil tamperings, then given back for sock-drawer hoarding that lasts only days, not the promised months. Fruits are the lab-made, ascorbic-acid flavors of Skittles and Starbursts and Jelly Bellies, raisins are Raisinets, almonds mean marzipan and Almond Joys, milk is a vehicle for Nesquik strawberry or chocolate syrups, sucked through red licorice Twizzler straws. It is the quivering anticipation of birthday cakes with the biggest pinkest prettiest sugar rose for the birthday girl, the backyard piñata attacked and attacked and attacked with baseball bat frenzy until she is showered with manna. Easter is creamy Cadbury Eggs, Thanksgiving is candied yam casserole peaked with marshmallow crust, Christmas is the faux-minty red-and-white swirl of candy canes sucked into spears, the pot of melting caramel meant to golden the popcorn garlands and shellac the apples, instead mouth-spooned away at the stove. It is the zoo the circus the carnival, all ballet-pink gossamer puffs of cotton candy crunched to hard coral between her teeth. It is the bloodbeat rush, the delirium, sailing soar into bliss, and then the plummet and bitter crash, the jitters and shakes. It is acidic pantings and acrid sweatings and belly flesh bulging around the elastic of panties and training bras, it is claiming a stomachache to duck the bleachers-running or rope-climbing or naked locker room of gym, it is the yearly mouthful of Novocain needle and new silver-filling glints rewarded with a gleaming, jewel-colored lollipop. It is the terror of beach parties or swim parties and the mumbled, towel-mummied excuses of sunburning so easily. It is her teenage Saturday nights baking Betty Crocker brownies alchemized into bigger higher happiness soars with added bags of Reese’s Pieces and Nestlé chocolate chips. It is the sweet boy, the cute kind caring boy in English lit who smiles, compliments her understanding of Shakespearean metaphor, comes to her house after school for quiz study, sits on her bed and eats half a pan of her offered brownies while she chatters away, then sweet-mouth kisses her silent, once, the chocolate masking the breath going sour, then nudges her head to his lap, to his opening fly, to the hard sucking candy and sweat and come filling her mouth, her throat, her belly, even as she suspects, knows, this is all she will get, all she deserves, but let me have it now, this sweetness, more and more and more, give it to me, it is so good.