Neurons Fire Quotes

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.

Neurons that fire together wire together. Mental states become neural traits. Day after day, your mind is building your brain. This is what scientists call experience-dependent neuroplasticity,

When the brain is working to remember something, similar patterns of neurons fire as they did during the perception of the original event. These networks are linked, and each time we revisit them, they become stronger and more associated. But they need the proper retrieval cues--words, smells, images-- for them to be brought back as memories

Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn't it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain? Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don't want to go to Montana. How do I know I really want to go and it isn't just some neurons firing or something? Maybe it's just an accidental flash in the medulla and suddenly there I am in Montana and I find out I really didn't want to go there in the first place. I can't control what happens in my brain, so how can I be sure what I want to do ten seconds from now, much less Montana next summer? It's all this activity in the brain and you don't know what's you as a person and what's some neuron that just happens to fire or just happens to misfire.

I understand the mechanism of my own thinking. I know precisely how I know, and my understanding is recursive. I understand the infinite regress of this self-knowing, not by proceeding step by step endlessly, but by apprehending the limit. The nature of recursive cognition is clear to me. A new meaning of the term "self-aware." Fiat logos. I know my mind in terms of a language more expressive than any I'd previously imagined. Like God creating order from chaos with an utterance, I make myself anew with this language. It is meta-self-descriptive and self-editing; not only can it describe thought, it can describe and modify its own operations as well, at all levels. What Gödel would have given to see this language, where modifying a statement causes the entire grammar to be adjusted. With this language, I can see how my mind is operating. I don't pretend to see my own neurons firing; such claims belong to John Lilly and his LSD experiments of the sixties. What I can do is perceive the gestalts; I see the mental structures forming, interacting. I see myself thinking, and I see the equations that describe my thinking, and I see myself comprehending the equations, and I see how the equations describe their being comprehended. I know how they make up my thoughts. These thoughts.

In humans as well, it is because your loved one existed that certain neurons fire together and certain proteins are folded in your brain in particular ways. It is because your loved one lived, and because you loved each other, that means when the person is no longer in the outer world, they still physically exist—in the wiring of the neurons of your brain.

Like daffodils in the early days of spring, my neurons were resprouting receptors as the winter of the illness ebbed.

...he'd know about the role of mirror neurons in the brain, special cells in the premotor cortex that fire right before a person reaches for a rock, steps forward, turns away, begins to smile.Amazingly, the same neurons fire whether we do something or watch someone else do the same thing, and both summon similar feelings. Learning form our own mishaps isn't as safe as learning from someone else's, which helps us decipher the world of intentions, making our social whirl possible. The brain evolved clever ways to spy or eavesdrop on risk, to fathom another's joy or pain quickly, as detailed sensations, without resorting to words. We feel what we see, we experience others as self.

The really amazing thing about all this is no matter what you believe,it took some doing to get from a point where there was nothing, to a point where all the right neurons fire and pop so that we can make decisions. More amazing is how even though that's become second nature, we all still manage to screw it up.

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were. And brain cells weren’t even the lower limit. The origins of thought were buried so deep they predated multicellular life itself: neurotransmitters in choanoflagellates, potassium ion gates in Monosiga. I am a colony of microbes talking to itself, Brüks reflected.

Your mind is the projection screen every writer steals; it is the firing of your neurones that makes every book come alive. You are the electricity that turns it on. A book cannot live until the touch of your hand on the first page brings it alive. A writer is essentially typing blank pages – shouting out spells in the dark – until the words are read by you, and the magic explodes into your head, and no one else's.

...what draws us into a story and keeps us there is the firing of our dopamine neurons, signaling that intriguing information is on the way.

We use objects to navigate spaces, making a map in our heads as neurons fire, pathways so well-worn we don’t even know we reference them as we move from one location to the next, the same pattern. Every day.

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were.

When neurons fire together, they grow new connections between them. Over time, the connections that result from firing lead to “rewiring” in the brain. This

Don't worry dreams aren't real. They're just neurons firing randomly in your brain.

A good idea is a network. A specific constellation of neurons—thousands of them—fire in sync with each other for the first time in your brain, and an idea pops into your consciousness.

Just like we need food and water, humans need each other. A brain study revealed that when placed in an MRI, a patient's reward center lit up when another person sat in the room. Neurons fire when talk to someone, think about someone, and they go haywire when we hold someone's hand. Our brains and bodies are actually programmed to seek each other out and connect. So then why do so many people prefer being alone? Why do we often run for the hills when we feel the slightest connection? Why we do we feel compelled to fight what we're hardwired to do? Maybe it's because when we find someone or something to hold on to, that feeling becomes like air. And we're terrified we're going to lose it. And trust me, you can get pretty good at the alone thing. But most things are better when they're shared with someone else.

What makes aerobic exercise so powerful is that it’s our evolutionary method of generating that spark. It lights a fire on every level of your brain, from stoking up the neurons’ metabolic furnaces to forging the very structures that transmit information from one synapse to the next.

To live for your children seems a normal thing, a respectable one; to live because of your children is something else. Mine are the blood of me, and the oxygen in that blood, the airflow and the neurons firing and the stretch and release of muscles in limbs, they are the foundations that make up my skeleton, all the collagen and calcium upon which I stand and fall, and the pulse and the flow and the beat. But I think maybe this is too much for them to be. The breath of a man. The life of him. I think it is too heavy a thing for children to carry.

One of the greatest discoveries in recent years was to find that mirror neurons fire also when you do things. It is as if part of your brain is observing yourself as an outsider. You are a story you tell yourself.

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.” Helena leans forward, snaps her fingers. “Just what your brain does to interpret a simple stimulus like that is incredible. The visual and auditory information arrive at your eyes and ears at different speeds, and then are processed by your brain at different speeds. Your brain waits for the slowest bit of stimulus to be processed, then reorders the neural inputs correctly, and lets you experience them together, as a simultaneous event—about half a second after what actually happened. We think we’re perceiving the world directly and immediately, but everything we experience is this carefully edited, tape-delayed reconstruction.

Criticisms of a society filled with fools have no power in them to bother the sage that has emerged from the agonizing fire of misery.

Whenever we use our brain, we fire certain neuronal connections, and the more these connections get used, the stronger they become.

You can think about this decoupling as the converse of neurons that fire together wire together. Here, neurons out of sync fail to link.

The revolution is built on three simple facts. (1) Every human movement, thought, or feeling is a precisely timed electric signal traveling through a chain of neurons—a circuit of nerve fibers. (2) Myelin is the insulation that wraps these nerve fibers and increases signal strength, speed, and accuracy. (3) The more we fire a particular circuit, the more myelin optimizes that circuit, and the stronger, faster, and more fluent our movements and thoughts become.

He always reminded us that every atom in our bodies was once part of a distant star that had exploded. He talked about how evolution moves from simplicity toward complexity, and how human intelligence is the highest known expression of evolution. I remember him telling me that a frog's brain is much more complex than a star. He saw human consciousness as the first neuron of the universe coming to life and awareness. A spark in the darkness, waiting to spread to fire.

We are our nervous systems, the complex combination of billions of neurons firing in distinctive patterns. What's more exciting than spending my life figuring out what a little chunk of these neurons can accomplish?

He was not above calling a book unreadable. But their literary merit wasn’t important at this moment. They were words strung together to represent the firing of neurons and the transferring of information through synapses. They were human minds set into paper, and Sebastian loved every single one of them, even the ones he found disposable.

If you want to see philosophy in action, pay a visit to a robo-rat laboratory. A robo-rat is a run-ofthe-mill rat with a twist: scientists have implanted electrodes into the sensory and reward areas in the rat’s brain. This enables the scientists to manoeuvre the rat by remote control. After short training sessions, researchers have managed not only to make the rats turn left or right, but also to climb ladders, sniff around garbage piles, and do things that rats normally dislike, such as jumping from great heights. Armies and corporations show keen interest in the robo-rats, hoping they could prove useful in many tasks and situations. For example, robo-rats could help detect survivors trapped under collapsed buildings, locate bombs and booby traps, and map underground tunnels and caves. Animal-welfare activists have voiced concern about the suffering such experiments inflict on the rats. Professor Sanjiv Talwar of the State University of New York, one of the leading robo-rat researchers, has dismissed these concerns, arguing that the rats actually enjoy the experiments. After all, explains Talwar, the rats ‘work for pleasure’ and when the electrodes stimulate the reward centre in their brain, ‘the rat feels Nirvana’. To the best of our understanding, the rat doesn’t feel that somebody else controls her, and she doesn’t feel that she is being coerced to do something against her will. When Professor Talwar presses the remote control, the rat wants to move to the left, which is why she moves to the left. When the professor presses another switch, the rat wants to climb a ladder, which is why she climbs the ladder. After all, the rat’s desires are nothing but a pattern of firing neurons. What does it matter whether the neurons are firing because they are stimulated by other neurons, or because they are stimulated by transplanted electrodes connected to Professor Talwar’s remote control? If you asked the rat about it, she might well have told you, ‘Sure I have free will! Look, I want to turn left – and I turn left. I want to climb a ladder – and I climb a ladder. Doesn’t that prove that I have free will?

As the blood poured from his tattered heart into the open air and his brain suffocated, all those incomplete thoughts of Wittgenstein decayed with the dying neurons. Neural connections in the gray matter storing memories and ideas in their ordered configurations fired across the gaps, last gaps of mental life. Thoughts on Truth and Will were erased as flesh sloshed soft and limp against alabaster, no more than rotting human fruit.

I thought if I stared a little longer I could see right inside his head, to his brain, and I don’t know why that turned me on so much. I wanted to witness the workings of his mind, the firing synapses, information traveling safely inside neurons to different parts of his body. A few made it to his hand, and they must have told him to keep holding mine because he didn’t let go.

What molds our brain? Experience. Even into old age, our experiences actually change the physical structure of the brain. When we undergo an experience, our brain cells—called neurons—become active, or “fire.” The brain has one hundred billion neurons, each with an average of ten thousand connections to other neurons.

When you read a book, the neurons in your brain fire overtime, deciding what the characters are wearing, how they’re standing, and what it feels like the first time they kiss. No one shows you. The words make suggestions. Your brain paints the pictures.

Sebastian ran a finger over the spines of the books on the shelf. It did not matter to him what the titles were. They were books. They were filled with thoughts. Their relevance was debatable; he was sure some were exceptional while others were the works of lesser minds. He was not above calling a book unreadable. But their literary merit wasn’t important at this moment. They were words strung together to represent the firing of neurons and the transferring of information through synapses. They were human minds set into paper, and Sebastian loved every single one of them, even the ones he found disposable.

Neurons that fire together wire together.

The mind of the experienced book reader is a calm mind, not a buzzing one. When it comes to the firing of our neurons, it's a mistake to assume that more is better.

The more you repeat a thought, choice, behavior, experience, or emotion, the more those neurons fire and wire together and the more they will sustain a long-term relationship.

mental activity such as directing attention, actually shape the structure of the brain?” As we’ve seen, experience means neural firing. When neurons fire together, the genes in their nuclei—their master control centers—become activated and “express” themselves. Gene expression means that certain proteins are produced. These proteins then enable the synaptic linkages to be constructed anew or to be strengthened. Experience also stimulates the production of myelin, the fatty sheath around axons, resulting in as much as a hundredfold increase in the speed of conduction down the neuron’s length. And as we now know, experience can also stimulate neural stem cells to differentiate into wholly new neurons in the brain. This neurogenesis, along with synapse formation and myelin growth, can take place in response to experience throughout our lives. As discussed before, the capacity of the brain to change is called neuroplasticity We are now discovering how the careful focus of attention amplifies neuroplasticity by stimulating the release of neurochemicals that enhance the structural growth of synaptic linkages among the activated neurons.

What to call it - the spark of God? Survival instinct? The souped-up computer of an apex brain evolved from eons in the R&D of natural selection? You could practically see the neurons firing in the kid’s skull. His body was all spring and torque, a bundle of fast-twitch muscles that exuded faint floral whiffs of ripe pear. So much perfection in such a compact little person - Billy had to tackle him from time to time, wrestle him squealing to the ground just to get that little rascal in his hands, just your basic adorable thirty-month-old with big blue eyes clear as chlorine pools and Huggies poking out of his stretchy-waist jeans. So is this what they mean by the sanctity of life? A soft groan escaped Billy when he thought about that, the war revealed in this fresh and gruesome light. Oh. Ugh. Divine spark, image of God, suffer the little children and all that - there’s real power when words attach to actual things. Made him want to sit right down and weep, as powerful as that. He got it, yes he did, and when he came home for good he’d have to meditate on this, but for now it was best to compartmentalize, as they said, or even better not to mentalize at all.

Humans have always exalted dreams. Pindar of Thebes, the Greek lyric poet, suggested that the soul is more active while dreaming than while awake. He believed that during a dream, the awakened soul may see the future, “an award of joy or sorrow drawing near.” So it’s no wonder that humans were quick to reserve dreams for people alone; researchers for many years claimed dreams were a property of “higher” minds. But any pet owner who has heard her dog woof or seen his cat twitch during sleep knows that is not true. MIT researchers now know not only that rats dream, but what they dream about. Neurons in the brain fire in distinctive patterns while a rat in a maze performs particular tasks. The researchers repeatedly saw the exact same patterns reproduced while the rats slept—so clearly that they could tell what point in the maze the rat was dreaming about, and whether the animal was running or walking in the dream. The rats’ dreams took place in an area of the brain known to be involved with memory, further supporting a notion that one function of dreams is to help an animal remember what it has learned.

So who you are at any given moment depends on the detailed rhythms of your neuronal firing. During the day, the conscious you emerges from that integrated neural complexity. At night, when the interaction of your neurons changes just a bit, you disappear. Your loved ones have to wait until the next morning, when your neurons let the wave die and work themselves back into their complex rhythm. Only then do you return.

Neurons that fire together, wire together,’ meaning that activities that repeatedly activate a constellation of neurons cause those neurons to connect more closely, so if a child goes through puberty doing archery, or painting, or video games, or social media. It will cause lasting structural changes in the brain, especially if the activity is rewarding. This is how cultural experience changes the brain, producing a young adult who feels American instead of Japanese, or what is habitually in discover mode as opposed to defend mode.

Before the first step, before the first muscle twitches, before the first neuron fires, there comes a choice: stand still or move. You choose the right option. Then you repeat that choice one hundred thousand times. You don’t run thirty miles, you run a single step many times over. That’s all running is; that’s all anything is. If there’s somewhere you need to be, somewhere you need to get to, or if you need to change or move away from where or what you are, then that’s all it takes. A hundred thousand simple decisions, each one made correctly. You don’t have to think about the distance or the destination or about how far you’ve come or how far you have to go. You just have to think about what’s in front of you and how you’re going to move it behind you.

Our minds have the incredible capacity to both alter the strength of connections among neurons, essentially rewiring them, and create entirely new pathways. (It makes a computer, which cannot create new hardware when its system crashes, seem fixed and helpless).

As it turns out, you can function while your heart is being torn to shreds. Blood pumps, breath flows, neurons fire. What goes missing is the affect; a curious flatness to voice and actions that, if noted, speak of a hole so deep inside there’s no visible end to it.

You could practically see the neurons firing in the kid’s skull. His body was all spring and torque, a bundle of fast-twitch muscles that exuded faint floral whiffs of ripe pear. So much perfection in such a compact little person — Billy had to tackle him from time to time, wrestle him squealing to the ground just to get that little rascal in his hands, just your basic adorable thirty-month old with big blue eyes clear as chlorine pools and Huggies poking out of his stretchy-waist jeans. So is this what they meant by the sanctity of life?

When your brain is always engaged, when your neurons are always firing, when you find yourself in a continual mode of reacting and responding, instead of steering and directing, the best and brightest solutions that you are capable of producing rarely see the light of day.

Most of what you think of as your consciousness is neurons firing at random and making up an explanation for it afterwards. It’s not your fault. You were whittled into this shape by a million years of evolution. That’s why there’s a war on. You saw something you didn’t understand, and you tried to bite it.

Each electrical pulse—and resulting squirt of neurotransmitter—is not an order commanding the next neuron’s actions; it is more like a vote on what the next neuron should do. The whole pattern of activity is like a presidential election. Everyone votes on who the president should be, and depending on those votes, the country veers off in one direction or another. If you can change the number of votes in a few key swing states by only a few percentage points, you can dramatically change the course of the country. The same is true of the brain. By changing the firing rate of neurons in a few key regions, you can influence the pattern of activity in the entire brain.

The principle, now known as Hebbian learning, is succinctly described by the phrase ‘neurons that fire together wire together’.

Neurons that fire together, wire together.

The balance between excitatory and inhibitory inputs to a neuron determines whether it will fire.

When you walked through a park, the immersive world that surrounded you was something that existed inside your own brain as a pattern of neurons firing. The sensation of a bright blue sky wasn't something high above you, it was something in your visual cortex, and your visual cortex was in the back of your brain. All the sensations of that bright world were really happening in that quiet cave of bone you called your skull, the place where you lived and never, ever left. If you really wanted to say hello to someone, to the actual person, you wouldn't shake their hand, you'd knock gently on their skull and say "How are you doing in there?" That was what people were, that was where they really lived. And the picture of the park that you thought you were walking through was something that was visualized inside your brain as it processed the signals sent down from your eyes and retina. It wasn't a lie like the Buddhists thought, there wasn't something terribly mystical and unexpected behind the veil of Maya, what lay beyond the illusion of the park was just the actual park, but it was all still illusion.

The amazing flexibility of our minds seems nearly irreconcilable with the notion that our brains must be made out of fixed-rule hardware, which cannot be reprogrammed. We cannot make our neurons fire faster or slower, we cannot rewire our brains, we cannot redesign the interior of a neuron, we cannot make [any] choices about the hardware—and yet, we can control how we think.

Do you ever wonder how we all got here? On Earth, I mean. Forget the song and dance about Adam and Eve, which I know is a load of crap. My father likes the myth of the Pawnee Indians, who say that the star deities populated the world: Evening Star and Morning Star hooked up and gave birth to the first female. The first boy came from the Sun and the Moon. Humans rode in on the back of a tornado. Mr. Hume, my science teacher, taught us about this primordial soup full of natural gases and muddy slop and carbon matter that somehow solidified into one-celled organisms called choanoflagellates... which sound a lot more like a sexually transmitted disease than the start of the evolutionary chain, in my opinion. But even once you get there, it's a huge leap from an amoeba to a monkey to a whole thinking person. The really amazing thing about all this is no matter what you believe, it took some doing to get from a point where there was nothing, to a point where all the right neurons fire and pop so that we can make decisions. More amazing is how even though that's become second nature, we all still manage to screw it up.

Neurons on the two ends of the log-normal distribution of activity organize themselves differently. Fast-firing neurons are better connected with each other and burst more than slow-firing neurons. The more strongly connected faster firing neurons form a “rich club” with better access to the entire neuronal population, share such information among themselves, and, therefore, generalize across situations. In contrast, slow firing neurons keep their independent solitude and elevate their activity only in unique situations. The two tails of the distribution are maintained by a homeostatic process during non-REM sleep. The emerging picture is that a simple measure, such as the baseline firing frequency, can reveal a lot about a neuron’s role in computation and its wiring properties. The

Prone in the prison of this question, Hell or salvation, fired incessantly from the neuronal network in the pallium cowering in the base of the skull, lying motionless or walking out of the question.

This new science of performance argues that you get better at a skill as you develop more myelin around the relevant neurons, allowing the corresponding circuit to fire more effortlessly and effectively. To be great at something is to be well myelinated. This understanding is important because it provides a neurological foundation for why deliberate practice works. By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill. The reason, therefore, why it’s important to focus intensely on the task at hand while avoiding distraction is because this is the only way to isolate the relevant neural circuit enough to trigger useful myelination. By contrast, if you’re trying to learn a complex new skill (say, SQL database management) in a state of low concentration (perhaps you also have your Facebook feed open), you’re firing too many circuits simultaneously and haphazardly to isolate the group of neurons you actually want to strengthen. In

One day, I had just finished making her lunch. I hadn't written the note yet. Emma saw the lunch bag on the counter without a note, and I saw the neurons firing in her brain. She scooped up the bag, came over to me with pleading eyes, and simply asked,'Napkin note?' that's when i knew it mattered...I realized that these were moments when i could help shepherd her, guide her into becoming a young woman.

Meditation has also been proven scientifically to untangle and rewire the neurological pathways in the brain that make up the conditioned personality. Buddhist monks, for example, have had their brains scanned by scientists as they sat still in deep altered states of consciousness invoked by transcendental meditation and the scientists were amazed at what they beheld. The frontal lobes of the monks lit up as bright as the sun! They were in states of peace and happiness the scientists had never seen before. Meditation invokes that which is known in neuroscience as neuroplasticity; which is the loosening of the old nerve cells or hardwiring in the brain, to make space for the new to emerge. Meditation, in this sense, is a fire that burns away the old or conditioned self, in the Bhagavad Gita, this is known as the Yajna; “All karma or effects of actions are completely burned away from the liberated being who, free from attachment, with his physical mind enveloped in wisdom (the higher self), performs the true spiritual fire rite.

However, if one or more of the neurons are in the predictive state, our theory says, only those neurons spike and the other neurons are inhibited. Thus, when an input arrives that is unexpected, multiple neurons fire at once. If the input is predicted, then only the predictive-state neurons become active. This is a common observation about the neocortex: unexpected inputs cause a lot more activity than expected ones.

The firing pattern of both mirror and canonical neurons in area F5 shows clearly that perception and action are not separated in the brain. They are simply two sides of the same coin, inextricably linked to each other. Some

is easy to recall from everyday experience that neither electricity nor magnetism have visual properties. So, on its own, it’s not hard to grasp that there is nothing inherently visual, nothing bright or colored about that candle flame. Now let these same invisible electromagnetic waves strike a human retina, and if (and only if) the waves each happen to measure between 400 and 700 nanometers in length from crest to crest, then their energy is just right to deliver a stimulus to the 8 million cone-shaped cells in the retina. Each in turn sends an electrical pulse to a neighbor neuron, and on up the line this goes, at 250 mph, until it reaches the warm, wet occipital lobe of the brain, in the back of the head. There, a cascading complex of neurons fire from the incoming stimuli, and we subjectively perceive this experience as a yellow brightness occurring in a place we have been conditioned to call “the external world.” Other creatures receiving the identical stimulus will experience something altogether different, such as a perception of gray, or even have an entirely dissimilar sensation. The point is, there isn’t a “bright yellow” light “out there” at all. At most, there is an invisible stream of electrical and magnetic pulses. We are totally necessary for the experience of what we’d call a yellow flame. Again, it’s correlative.

The healthy brain is a symphony of 100 billion neurons, the actions of each individual brain cell harmonizing into a whole that enables thoughts, movements, memories, or even just a sneeze. But it takes only one dissonant instrument to mar the cohesion of a symphony. When neurons begin to play nonstop, out of tune, and all at once because of disease, trauma, tumor, lack of sleep, or even alcohol withdrawal, the cacophonous result can be a seizure.

When jungles of neurons fire in unison to support a new thought, an additional chemical (a protein) is created within the nerve cell and makes its way to the cell’s center, or nucleus, where it lands in the DNA. The protein then switches on several genes. Since the job of the genes is to make proteins that maintain both the structure and function of the body, the nerve cell then quickly makes a new protein to create new branches between nerve cells.

If someone close to us dies, then, based on what we know about object-trace cells, our neurons still fire every time we expect our loved one to be in the room. And this neural trace persists until we can learn that our loved one is never going to be in our physical world again. We must update our virtual maps, creating a revised cartography of our new lives. Is it any wonder that it takes many weeks and months of grief and new experiences to learn our way around again?

What is Required by Paul Allen (fragment) 1 All elsewhere being World, how many times have I stood in the bright shadows of a wood, no track or trail leading in, out- as though ground cover renewed as I went through? I sometimes own the moments where I stand alone. Everything else is air and arbitrary firings of neurons we call memory if they happened, fantasy if they didn’t- same pictures. Call it prayer, then, the moments where I’m not aware even of how lovely the moment is- not liking, not disliking- not aware there is a moment until I’m back in the world and remember it- construct it in my mind as having been beautiful. 4 I’m too often bitten by silence. My mother called it dawdling, the ex, brooding. My students call it absent-minded professor. The kindest students bring me back gently. But I live most when silence, shade, and light like this harvest me, a kind of prayer I’m gathered to, not the prayer I clutter with will or words.

Science finds it hard to decipher the mysteries of the mind largely because we lack efficient tools. Many people, including many scientists, tend to confuse the mind with the brain, but they are really very different things. The brain is a material network of neurons, synapses and biochemicals. The mind is a flow of subjective experiences, such as pain, pleasure, anger and love. Biologists assume that the brain somehow produces the mind, and that biochemical reactions in billions of neurons somehow produce experiences such as pain and love. However, so far we have absolutely no explanation for how the mind emerges from the brain. How come when billions of neurons are firing electrical signals in a particular pattern, I feel pain, and when the neurons fire in a different pattern, I feel love? We haven’t got a clue. Hence even if the mind indeed emerges from the brain, at least for now studying the mind is a different undertaking than studying the brain.

Scientists have identified individual neurons, which fire, when a particular person has been recognized. Thus, [it is possible that] when a recipient’s brain analyzes the features of a person, who significantly impressed the donor, the donated organ may feed back powerful emotional messages, which signal recognition of the individual. Such feedback messages occur within milliseconds and the recipient [may even believe] that [he] knows the person.” —“Cellular Memory in Organ Transplants

Imagine having this incredible computer inside your head, billions of neurons all firing at once, giving you the ability to walk and talk and think and feel, and you chose to use all those unimaginable complexities to be mad at your brother for no reason.

All human behaviour, language, thoughts, feelings, actions, and consciousness emerge from this massively interconnected network of neurons. Each neuron is pretty dumb; it either fires in a certain situation or it doesn’t, but out of this mass dumbness comes great cleverness.

Albion Park on a fierce spring morning. A mad March day of ice and fire. Thomas's feet beat a tattoo on the path. Every hair, every bristle on his chin stands on end. He is a small star-ship of blazing neurons- He is a librarian on his way to work, half-blind with sun and cold and memory.

You gently leaned over her to kiss her forehead and pulled the blankets around her shoulders. No father can adequately articulate the experience of watching his sleeping child—it must be lived. Now, imagine you are walking out of her room. Could you turn around and look at her and believe that the sum of her existence rests in a mass of cells? Certainly not. But this is exactly how a rank secularist is obliged to view his daughter. She is nothing more than a genetic product of his and her mother’s DNA. The puffing of air through her tiny chest keeps her alive. Your time with her is precious, meaningful, but purely a biological phenomenon. Her thoughts and feelings can be traced to neuronal firing in her brain. One day you will die and she will die and that will be that. Life began through the splitting and rejoining of DNA and when they stopped functioning, she did too.

When we think thoughts, neurotransmitters at one branch of one neuron tree cross the synaptic gap to reach the root of another neuron tree. Once they cross that gap, the neuron fires with an electrical bolt of information. When we continue thinking the same thoughts, the neuron keeps firing in the same ways, strengthening the relationship between the two cells so that they can more readily convey a signal the next time those neurons fire. As a result, the brain shows physical evidence that something was not only learned, but also remembered. This process of selective strengthening is called synaptic potentiation.

Thus, shorter refractory periods mean a higher rate of action potentials. So is testosterone causing action potentials in these neurons? No. It’s causing them to fire at a faster rate if they are stimulated by something else. Similarly, testosterone increases amygdala response to angry faces, but not to other sorts.

what is called the "subconscious mind" is actually a result of the neural activity of the brain itself — your brain's neurons silently firing, without your control or awareness — rather than being a part of the activity of the "mind." In fact, the process can take place without the brain discussing it with the mind at all.

Simply put, we are looking for a reason to care. So for a story to grab us, not only must something be happening, but also there must be a consequence we can anticipate. As neuroscience reveals, what draws us into a story and keeps us there is the firing of our dopamine neurons, signaling that intriguing information is on its way. This means that whether it’s an actual event unfolding or we meet the protagonist in the midst of an internal quandary or there’s merely a hint that something’s slightly “off” on the first page, there has to be a ball already in play. Not the preamble to the ball. Not all the stuff you have to know to really understand the ball. The ball itself.

You can think of it this way: Thought is electrical activity—a bunch of neurons firing up and connecting to each other—but all this mental circuitry has to function in a liquid environment that swarms with hormones and other small molecules whose levels can register in the mind as emotions. When the liquid starts turning into tar—or worse, going into whirlpool mode and threatening total disintegration—the only way out is to strengthen the neuronal scaffolding and try to keep the circuits dry. From “think in complete sentences” the rule evolved into “think.” So I would get to the answers by thinking—not by dreaming or imagining and of course not by praying or pleading to imaginary others.

Gain is a parameter in neural network modeling, which influences the probability that a neuron fires at a given activation level. Single cell recordings in non-human primates have shown that the likelihood of a neuron firing, given a constant sensory input, is enhanced when the stimulus dimension that is preferentially processed by the neuron is attended to.11

And of those responding neurons, 51 fired in response to only a single person or thing. One neuron responded only to Halle Berry, for example. Amazingly, the “Halle Berry” neuron responded to any picture of her, including one in which she was dressed as the masked Catwoman. Even the name Halle Berry triggered that neuron, which was silent at the sight of other actresses or their names.

When Olsson inserted the microelectrodes into Armillaria’s hyphal strands, he detected regular action potential–like impulses, firing at a rate very close to that of animals’ sensory neurons—around four impulses per second, which traveled along hyphae at a speed of at least half a millimeter per second, some ten times faster than the fastest rate of fluid flow measured in a fungal hypha.

Like any other thought, a hunch is simply a network of cells firing inside your brain in an organized pattern. But for that hunch to blossom into something more substantial, it has to connect with other ideas. The hunch requires an environment where surprising new connections can be forged: the neurons and synapses of the brain itself, and the larger cultural environment that the brain occupies.

To understand the role of myelin in improvement, keep in mind that skills, be they intellectual or physical, eventually reduce down to brain circuits. This new science of performance argues that you get better at a skill as you develop more myelin around the relevant neurons, allowing the corresponding circuit to fire more effortlessly and effectively. To be great at something is to be well myelinated.

But now I speculate re the ants' invisible organ of aggregate thought... if, in a city park of broad reaches, winding paths, roadways, and lakes, you can imagine seeing on a warm and sunny Sunday afternoon the random and unpredictable movement of great numbers of human beings in the same way... if you watch one person, one couple, one family, a child, you can assure yourself of the integrity of the individual will and not be able to divine what the next moment will bring. But when the masses are celebrating a beautiful day in the park in a prescribed circulation of activities, the wider lens of thought reveals nothing errant, nothing inconstant or unnatural to the occasion. And if someone acts in a mutant un-park manner, alarms go off, the unpredictable element, a purse snatcher, a gun wielder, is isolated, surrounded, ejected, carried off as waste. So that while we are individually and privately dyssynchronous, moving in different ways, for different purposes, in different directions, we may at the same time comprise, however blindly, the pulsing communicating cells of an urban over-brain. The intent of this organ is to enjoy an afternoon in the park, as each of us street-grimy urbanites loves to do. In the backs of our minds when we gather for such days, do we know this? How much of our desire to use the park depends on the desires of others to do the same? How much of the idea of a park is in the genetic invitation on nice days to reflect our massive neuromorphology? There is no central control mechanism telling us when and how to use the park. That is up to us. But when we do, our behavior there is reflective, we can see more of who we are because of the open space accorded to us, and it is possible that it takes such open space to realize in simple form the ordinary identity we have as one multicellular culture of thought that is always there, even when, in the comparative blindness of our personal selfhood, we are flowing through the streets at night or riding under them, simultaneously, as synaptic impulses in the metropolitan brain. Is this a stretch? But think of the contingent human mind, how fast it snaps onto the given subject, how easily it is introduced to an idea, an image that it had not dreamt of thinking of a millisecond before... Think of how the first line of a story yokes the mind into a place, a time, in the time it takes to read it. How you can turn on the radio and suddenly be in the news, and hear it and know it as your own mind's possession in the moment's firing of a neuron. How when you hear a familiar song your mind adopts its attitudinal response to life before the end of the first bar. How the opening credits of a movie provide the parameters of your emotional life for its ensuing two hours... How all experience is instantaneous and instantaneously felt, in the nature of ordinary mind-filling revelation. The permeable mind, contingently disposed for invasion, can be totally overrun and occupied by all the characteristics of the world, by everything that is the case, and by the thoughts and propositions of all other minds considering everything that is the case... as instantly and involuntarily as the eye fills with the objects that pass into its line of vision.

At the level of the fifth chakra, our attention moves from the physical plane into the subtler etheric fields. Commonly known as the aura, this etheric field is generated by the totality of internal processes—from the energetic exchange of subatomic particles to the digestion of food in our cells, from the firing of neurons to our current emotional state, and on to the larger rhythms of our outer activities. Our very life force can be seen as a stream of pulsating energy. When the stream is not fragmented by blocks in the body armor, then pulsation moves freely through the body and out into the world. This streaming creates a resonant, etheric field around the body—an aura of wholeness. A resonant field makes coherent connections with the outside world. A fragmented field makes fragmented connections.

Scientists have discovered something called ‘mirror neurons.’ A mirror neuron is one that will fire in your brain when you perform an action and also when you watch that same action being performed by someone else. Why we have these neurons is a mystery. Maybe they’ve helped us become more empathetic. When you see or read about someone else’s bad news, maybe a part of you is experiencing it too. It occurred to me that when we watch videos of people falling down, we are waiting for the moment of impact- for a bruise, a hurt, a collision, and that expectation makes us full participants in the event. Every fall we see is our own, and all of us are falling all the time. I wondered if the same would hold true if I reversed the fall. Would our neurons mirror that rising? Are all of us rising right now? Are you?

(1) Every human movement, thought, or feeling is a precisely timed electric signal traveling through a chain of neurons—a circuit of nerve fibers. (2) Myelin is the insulation that wraps these nerve fibers and increases signal strength, speed, and accuracy. (3) The more we fire a particular circuit, the more myelin optimizes that circuit, and the stronger, faster, and more fluent our movements and thoughts become.

Dancing for Dopamine There is an old saying that “neurons that fire together wire together.” It simply means your brain can start associating feelings with certain experiences. For example, dance every day to the same happy song with your baby, or your pet, or a friend on facetime. After a week, play that song while folding laundry or doing dishes. Your brain has now associated happiness with your song and will provide the same dopamine reward when you hear it.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

Such networks of neurons are built following the principle that “cells that fire together, wire together” (Hebb’s rule). In short, neurons that are frequently active at the same time tend to become associated and end up connecting with one another. This principle has major implications for brain fitness. First, the more a network of neurons is activated (i.e., the more often the neurons fire together), the stronger the connections become. If a network supporting a brain function is repeatedly stimulated through practice and training, it will become stronger, contributing to the optimization of that brain function. Second, by contrast, the less a network of neurons is activated the weaker the connections become, and weak connections end up dying. This accounts for the popular idea “use it or lose it” – brain functions that are not stimulated end up losing their efficiency since the neural networks supporting them weaken or dissipate.

The process of self-exploration begins with simple things, and becomes progressively harder. At first, we realize that we do not control the world outside us. I don’t decide when it rains. Then we realize that we do not control what’s happening inside our own body. I don’t control my blood pressure. Next, we understand that we don’t even govern our brain. I don’t tell the neurons when to fire. That’s more difficult. Ultimately we should realize that we do not control our desires.

Just consider the next thought that pops up in your mind. Where did it come from? Did you freely choose to think it, and only then did you think it? Certainly not. The process of self-exploration begins with simple things, and becomes progressively harder. At first, we realise that we do not control the world outside us. I don’t decide when it rains. Then we realise that we do not control what’s happening inside our own body. I don’t control my blood pressure. Next, we understand that we don’t even govern our brain. I don’t tell the neurons when to fire. Ultimately we should realise that we do not control our desires, or even our reactions to these desires. Realising this can help us become less obsessive about our opinions, about our feelings, and about our desires. We don’t have free will, but we can be a bit more free from the tyranny of our will. Humans usually give so much importance to their desires that they try to control and shape the entire world according to these desires. In pursuit of their cravings, humans fly to the moon, wage world wars, and destabilise the entire ecosystem. If we understand that our desires are not the magical manifestations of free choice, but rather are the product of biochemical processes (influenced by cultural factors that are also beyond our control), we might be less preoccupied with them. It is better to understand ourselves, our minds and our desires rather than try to realise whatever fantasy pops up in our heads.

Scientists have found that when test monkeys spent five minutes learning how to use a rake, some of the neurons that responded to touching their hands began behaving in a new way. They began to fire in response to stimuli at the end of the rake, not on the monkey’s hand. Other neurons in the brain respond to things that appear to lie within arm’s reach. Training the monkeys to use the rakes caused these neurons to change—reacting to objects lying within rake’s reach rather than arm’s reach.

The process of self-exploration begins with simple things, and becomes progressively harder. At first, we realise that we do not control the world outside us. I don’t decide when it rains. Then we realise that we do not control what’s happening inside our own body. I don’t control my blood pressure. Next, we understand that we don’t even govern our brain. I don’t tell the neurons when to fire. Ultimately we should realise that we do not control our desires, or even our reactions to these desires.

Some people believe that mirror neurons are also central to our ability to empathize with others and may even account for the emergence of gestural communication and spoken language. What we do know is that certain neurons increase their firing rate when we perform object-oriented actions with our hands (grasping, manipulating) and communicative or ingestive actions with our mouths. These neurons also fire, albeit less rapidly, whenever we witness the same actions performed by other people. Research

An initial counter to a radical scepticism is that magic does not derive from strange whims or deliberate irrationality. Much effort has gone into the construction of a mechanistic universe in Western thought, in which planets or atoms are moved by forces, and living things are characterized by biochemical reactions or sometimes the firing of neurons. Equal effort in other cultures has gone into denying differences between the animate and the inanimate, the living and non-living, the human and non-human.

Revelation. I understand the mechanism of my own thinking. I know precisely how I know, and my understanding is recursive. I understand the infinite regress of this self-knowing, not by proceeding step by step endlessly, but by apprehending the limit. The nature of recursive cognition is clear to me. A new meaning of the term ‘self-aware.’ Fiat logos. I know my mind in terms of a language more expressive than any I’d previously imagined. Like God creating order from chaos with an utterance, I make myself anew with this language. It is meta-self-descriptive and self-editing; not only can it describe thought, it can describe and modify its own operations as well, at all levels. What Gödel would have given to see this language, where modifying a statement causes the entire grammar to be adjusted. With this language, I can see how my mind is operating. I don’t pretend to see my own neurons firing; such claims belong to John Lilly and his LSD experiments of the sixties. What I can do is perceive the gestalts; I see the mental structures forming, interacting. I see myself thinking, and I see the equations that describe my thinking, and I see myself comprehending the equations, and I see how the equations describe their being comprehended. I know how they make up my thoughts. These thoughts. Initially I am overwhelmed by all this input, paralyzed with awareness of my self. It is hours before I can control the flood of self-describing information. I haven’t filtered it away, nor pushed it into the background. It’s become integrated into my mental processes, for use during my normal activities. It will be longer before I can take advantage of it, effortlessly and effectively, the way a dancer uses her kinesthetic knowledge. All that I once knew theoretically about my mind, I now see detailed explicitly. The undercurrents of sex, aggression, and self-preservation, translated by the conditioning of my childhood, clash with and are sometimes disguised as rational thought. I recognize all the causes of my every mood, the motives behind my every decision. What

But perhaps the newest and most exciting instrument in the neurologist’s tool kit is optogenetics, which was once considered science fiction. Like a magic wand, it allows you to activate certain pathways controlling behavior by shining a light beam on the brain. Incredibly, a light-sensitive gene that causes a cell to fire can be inserted, with surgical precision, directly into a neuron. Then, by turning on a light beam, the neuron is activated. More importantly, this allows scientists to excite these pathways, so that you can turn on and off certain behaviors by flicking a switch. Although this technology is only a decade old, optogenetics has already proven successful in controlling certain animal behaviors. By turning on a light switch, it is possible to make fruit flies suddenly fly off, worms stop wiggling, and mice run around madly in circles. Monkey trials are now beginning, and even human trials are in discussion. There is great hope that this technology will have a direct application in treating disorders like Parkinson’s and depression.

When repeated shocks and repeated release of serotonin are paired with the firing of the sensory neuron in associative learning, a signal is sent to the nucleus of the sensory neuron. This signal activates a gene, CREB-1, which leads to the growth of new connections between the sensory and motor neuron (fig. 4.5, right) (Bailey and Chen 1983; Kandel 2001). These connections are what enable a memory to persist. So if you remember anything of what you have read here, it will be because your brain is slightly different than it was before you started to read.

In fact, we’re not smart and we have bodies—we’re smart because we have bodies.7 The heart has about 40,000 neurons that play a central role in shaping emotion, perception, and decision making. The stomach and intestines complete this network, containing more than 500 million nerve cells, 100 million neurons, 30 different neurotransmitters, and 90 percent of the body’s supply of serotonin (one of the major neurochemicals responsible for mood and well-being). This “second brain,” as scientists have dubbed it, lends some empirical support to the persistent notion of gut instinct.

Whatever happens to a baby contributes to the emotional and perceptual map of the world that its developing brain creates. As my colleague Bruce Perry explains it, the brain is formed in a “use-dependent manner.”5 This is another way of describing neuroplasticity, the relatively recent discovery that neurons that “fire together, wire together.” When a circuit fires repeatedly, it can become a default setting—the response most likely to occur. If you feel safe and loved, your brain becomes specialized in exploration, play, and cooperation; if you are frightened and unwanted, it specializes in managing feelings of fear and abandonment. As infants and

He postulated that many neurons can combine into a coalition, becoming a single processing unit. The connection patterns of these units, which can change, make up the algorithms (which can also change with the changing connection patterns) that determine the brain’s response to a stimulus. From this idea came the mantra “Cells that fire together wire together.” According to this theory, learning has a biological basis in the “wiring” patterns of neurons. Hebb noted that the brain is active all the time, not just when stimulated; inputs from the outside can only modify that ongoing activity. Hebb’s proposal made sense to those designing artificial neural networks, and it was put to use in computer programs.

To give you a sense of the sheer volume of unprocessed information that comes up the spinal cord into the thalamus, let’s consider just one aspect: vision, since many of our memories are encoded this way. There are roughly 130 million cells in the eye’s retina, called cones and rods; they process and record 100 million bits of information from the landscape at any time. This vast amount of data is then collected and sent down the optic nerve, which transports 9 million bits of information per second, and on to the thalamus. From there, the information reaches the occipital lobe, at the very back of the brain. This visual cortex, in turn, begins the arduous process of analyzing this mountain of data. The visual cortex consists of several patches at the back of the brain, each of which is designed for a specific task. They are labeled V1 to V8. Remarkably, the area called V1 is like a screen; it actually creates a pattern on the back of your brain very similar in shape and form to the original image. This image bears a striking resemblance to the original, except that the very center of your eye, the fovea, occupies a much larger area in V1 (since the fovea has the highest concentration of neurons). The image cast on V1 is therefore not a perfect replica of the landscape but is distorted, with the central region of the image taking up most of the space. Besides V1, other areas of the occipital lobe process different aspects of the image, including: •  Stereo vision. These neurons compare the images coming in from each eye. This is done in area V2. •  Distance. These neurons calculate the distance to an object, using shadows and other information from both eyes. This is done in area V3. •  Colors are processed in area V4. •  Motion. Different circuits can pick out different classes of motion, including straight-line, spiral, and expanding motion. This is done in area V5. More than thirty different neural circuits involved with vision have been identified, but there are probably many more. From the occipital lobe, the information is sent to the prefrontal cortex, where you finally “see” the image and form your short-term memory. The information is then sent to the hippocampus, which processes it and stores it for up to twenty-four hours. The memory is then chopped up and scattered among the various cortices. The point here is that vision, which we think happens effortlessly, requires billions of neurons firing in sequence, transmitting millions of bits of information per second. And remember that we have signals from five sense organs, plus emotions associated with each image. All this information is processed by the hippocampus to create a simple memory of an image. At present, no machine can match the sophistication of this process, so replicating it presents an enormous challenge for scientists who want to create an artificial hippocampus for the human brain.

In real brains neural networks do not exist in isolation. They communicate with other networks by way of synaptic transmission. For example, in order to see an apple, instead of a roundish, reddish blob, the various features of the stimulus, each processed by different visual subsystems, have to be integrated. As we saw in Chapter 7, the problem of understanding the manner in which this occurs is called the binding problem. One popular solution to this problem is based on the notion of neuronal synchrony. Synchronous (simultaneous) firing, and thus binding, has been proposed as an explanation of consciousness (chap. 7), but our interest here is more in the ability of synchronous firing between cells in different interconnected regions to coordinate plasticity across the regions.

The discovery of mirror neurons was made by Giacomo Rizzolatti, Vittorio Gallase, and Marco Iaccoboni while recording from the brains of monkeys that performed certain goal-directed voluntary actions. For instance, when the monkey reached for a peanut, a certain neuron in its premotor cortex (in the frontal lobes) would fire. Another neuron would fire when the monkey pushed a button, a third neuron when he pulled a lever. The existence of such command neurons that control voluntary movements has been known for decades. Amazingly, a subset of these neurons had an additional peculiar property. The neuron fired not only (say) when the monkey reached for a peanut, but also when it watched another monkey reach for a peanut! These were dubbed “mirror neurons” or “monkey-see-monkey-do” neurons.

Hebb's notion, as you'll recall, is that "when an axon of cell A is near enough to excite cell B or repeatedly and consistently takes part in firing it, some growth process or metabolic changes take place in one or both cells such that A's efficiency, as one of the cells firing B, is increased." Let's expand this idea a little so we can see how it might apply to memory, and especially to a memory of the fact that two stimuli once occurred together. In order for two stimuli to be bound together in the mind, to become associated, the neural representations of the two events have to meet up in the brain. This means that there has to be some neuron (or a set of neurons) that receives information about both stimuli. Then, and only then, can the stimuli be linked together and an association be formed between them.

We must consider what we mean when we say that the spiking activity of a neuron 'encodes' information. We normally think of a code as something that conveys information from a sender to a recipient, and this requires that the recipient 'understands' the code. But the spiking activity of every neuron seems to encode information in a slightly different way, a way that depends on that neuron's intrinsic properties. So what sense can a recipient make of the combined input from many neurons that all use different codes? It seems that what matters must be the 'population code' - not the code that is used by single cells, but the average or aggregate signal from a population of neurons. In a now classic paper, Shadlen and Newsome considered how information is communicated among neurons of the cortex - neurons that typically receive between 3,000 and 10,000 synaptic inputs.They argued that, although some neural structures in the brain may convey information in the timing of successive spikes, when many inputs converge on a neuron the information present in the precise timing of spikes is irretrievably lost, and only the information present in the average input rate can be used. They concluded that 'the search for information in temporal patterns, synchrony and specially labeled spikes is unlikely to succeed' and that 'the fundamental signaling units of cortext may be pools on the order of 100 neurons in size.' The phasic firing of vasopressin cells is an extreme demonstration of the implausibility of spike patterning as a way of encoding usable information, but the key message - that the only behaviorally relevant information is that which is collectively encoded by the aggregate activity of a population - may be generally true.

grieving is a form of learning. Acute grief insists that we learn new habits, since our old habits automatically involved our loved one. Each day after their death, our brain is changed by our new reality, much as the rodents’ neurons had to learn to stop firing when the blue LEGO tower was removed from their box. Our little gray computer must update its predictions, as we can no longer expect our loved one to arrive home from work at six o’clock, or to pick up their cell phone when we call them with news. We learn that our loved one does not exist in the three dimensions of here, now, and close that we are expecting. We find new ways to express our continuing bonds, transforming what close looks like, because while our loved one remains in the epigenetics of our DNA and in our memories, we can no longer express our caring for them in the physical world or seek out their soothing touch.

Aerobic activity is beneficial in several ways. Exercise strengthens your cardiovascular system and improves your circulation, which means your body can deliver more blood to your brain when it’s working. Because the brain’s demand for oxygen and sugar rises when you’re concentrating hard, this can make the difference between grasping that insight or feeling like it’s just out of reach. A firing neuron uses as much energy as a leg muscle cell during a marathon. Further, sustained aerobic exercise stimulates the body to generate more small blood vessels in the brain, and a better-developed cerebral vasculature can deliver blood to the brain faster and more effectively. A 2012 study found that episodic memory improves as maximal oxygen capacity increases. (Conversely, comparative studies of adults who do and don’t exercise find that couch potatoes have lower scores on tests of executive function and processing speed and in middle age have faster rates of brain

Let’s start with an elementary example: Imagine hearing a series of identical notes, A A A A A. Each note elicits a response in the auditory areas of your brain—but as the notes repeat, those responses progressively decrease. This is called “adaptation,” a deceptively simple phenomenon that shows that your brain is learning to predict the next event. Suddenly, the note changes: A A A A A#. Your primary auditory cortex immediately shows a strong surprise reaction: not only does the adaptation fade away, but additional neurons begin to vigorously fire in response to the unexpected sound. And it is not just repetition that leads to adaptation: what matters is whether the notes are predictable. For instance, if you hear an alternating set of notes, such as A B A B A, your brain gets used to this alternation, and the activity in your auditory areas again decreases. This time, however, it is an unexpected repetition, such as A B A B B, that triggers a surprise response.

Unnecessary Creation gives you the freedom to explore new possibilities and follow impractical curiosities. Some of the most frustrated creative pros I’ve encountered are those who expect their day job to allow them to fully express their creativity and satisfy their curiosity. They push against the boundaries set by their manager or client and fret continuously that their best work never finds its way into the end product because of restrictions and compromises. A 2012 survey sponsored by Adobe revealed that nearly 75 percent of workers in the United States, United Kingdom, Germany, France, and Japan felt they weren’t living up to their creative potential. (In the United States, the number was closer to 82 percent!) Obviously, there’s a gap between what many creatives actually do each day and what they feel they are capable of doing given more resources or less bureaucracy. But those limitations aren’t likely to change in the context of an organization, where there is little tolerance for risk and resources are scarcer than ever. If day-to-day project work is the only work that you are engaging in, it follows that you’re going to get frustrated. To break the cycle, keep a running list of projects you’d like to attempt in your spare time, and set aside a specific time each week (or each day) to make progress on that list. Sometimes this feels very inefficient in the moment, especially when there are so many other urgent priorities screaming for your attention, but it can be a key part of keeping your creative energy flowing for your day-to-day work. You’ll also want to get a notebook to record questions that you’d like to pursue, ideas that you have, or experiments that you’d like to try. Then you can use your pre-defined Unnecessary Creation time to play with these ideas. As Steven Johnson explains in his book Where Good Ideas Come From, “A good idea is a network. A specific constellation of neurons—thousands of them—fire in sync with each other for the first time in your brain, and an idea pops into your consciousness. A new idea is a network of cells exploring the adjacent possible of connections that they can make in your mind.”18

Next, we discussed the relationship between the tabula rasa (blank slate) and preconfigured brain models. In the empiricist outside-in model, the brain starts out as blank paper onto which new information is cumulatively written. Modification of brain circuits scales with the amount of newly learned knowledge by juxtaposition and superposition. A contrasting view is that the brain is a dictionary with preexisting internal dynamics and syntactical rules but filled with initially nonsense neuronal words. A large reservoir of unique neuronal patterns has the potential to acquire significance for the animal through exploratory action and represents a distinct event or situation. In this alternative model, the diversity of brain components, such as firing rates, synaptic connection strengths, and the magnitude of collective behavior of neurons, leads to wide distributions. The two tails of this distribution offer complementary advantages: the “good-enough” brain can generalize and act fast; the “precision” brain is slow but careful and offers needed details in many situations.

Dopamine enhances the ability of neurons to transmit signals between one another. How? By acting as an agonist (as opposed to antagonist), or a substance that enhances neural activity. Dopamine binds to specific receptor molecule sites on the synaptic clefts of the neurons, as if it were the CTS that normally bind there.12 It increases the rate of neural firing in association with pattern recognition, which means that synaptic connections between neurons are likely to increase in response to a perceived pattern, thereby cementing those perceived patterns into long-term memory through the actual physical growth of new neural connections and the reinforcement of old synaptic links. Increasing dopamine increases pattern detection; scientists have found that dopamine agonists not only enhance learning but in higher doses can also trigger symptoms of psychosis, such as hallucinations, which may be related to that fine line between creativity (discriminate patternicity) and madness (indiscriminate patternicity). The dose is the key. Too much of it and you are likely to be making lots of Type I errors—false positives—in which you find connections that are not really there. Too little and you make Type II errors—false negatives—in which you miss connections that are real.

So many synapses,' Drisana said. 'Ten trillion synapses in the cortex alone.' Danlo made a fist and asked, 'What do the synapses look like?' 'They're modelled as points of light. Ten trillion points of light.' She didn't explain how neurotransmitters diffuse across the synapses, causing the individual neurons to fire. Danlo knew nothing of chemistry or electricity. Instead, she tried to give him some idea of how the heaume's computer stored and imprinted language. 'The computer remembers the synapse configuration of other brains, brains that hold a particular language. This memory is a simulation of that language. And then in your brain, Danlo, select synapses are excited directly and strengthened. The computer speeds up the synapses' natural evolution.' Danlo tapped the bridge of his nose; his eyes were dark and intent upon a certain sequence of thought. 'The synapses are not allowed to grow naturally, yes?' 'Certainly not. Otherwise imprinting would be impossible.' 'And the synapse configuration – this is really the learning, the essence of another's mind, yes?' 'Yes, Danlo.' 'And not just the learning – isn't this so? You imply that anything in the mind of another could be imprinted in my mind?' 'Almost anything.' 'What about dreams? Could dreams be imprinted?' 'Certainly.' 'And nightmares?' Drisana squeezed his hand and reassured him. 'No one would imprint a nightmare into another.' 'But it is possible, yes?' Drisana nodded her head. 'And the emotions ... the fears or loneliness or rage?' 'Those things, too. Some imprimaturs – certainly they're the dregs of the City – some do such things.' Danlo let his breath out slowly. 'Then how can I know what is real and what is unreal? Is it possible to imprint false memories? Things or events that never happened? Insanity? Could I remember ice as hot or see red as blue? If someone else looked at the world through shaida eyes, would I be infected with this way of seeing things?' Drisana wrung her hands together, sighed, and looked helplessly at Old Father. 'Oh ho, the boy is difficult, and his questions cut like a sarsara!' Old Father stood up and painfully limped over to Danlo. Both his eyes were open, and he spoke clearly. 'All ideas are infectious, Danlo. Most things learned early in life, we do not choose to learn. Ah, and much that comes later. So, it's so: the two wisdoms. The first wisdom: as best we can, we must choose what to put into our brains. And the second wisdom: the healthy brain creates its own ecology; the vital thoughts and ideas eventually drive out the stupid, the malignant and the parasitical.

The human brain is the most complex entity in the universe. It has between fifty and one hundred billion nerve cells, or neurons, each branched to form thousands of possible connections with other nerve cells. It has been estimated that laid end to end, the nerve cables of a single human brain would extend into a line several hundred thousand miles long. The total number of connections, or synapses, is in the trillions. The parallel and simultaneous activity of innumerable brain circuits, and networks of circuits, produces millions of firing patterns each and every second of our lives. The brain has well been described as “a supersystcm of systems.” Even though fully half of the roughly hundred thousand genes in the human organism are dedicated to the central nervous system, the genetic code simply cannot carry enough information to predetermine the infinite number of potential brain circuits. For this reason alone, biological heredity could not by itself account for the densely intertwined psychology and neurophysiology of attention deficit disorder. Experience in the world determines the fine wiring of the brain. As the neurologist and neuroscientist Antonio Damasio puts it, “Much of each brain’s circuitry, at any given moment in adult life, is individual and unique, truly reflective of that particular organism’s history and circumstances.” This is no less true of children and infants. Not even in the brains of genetically identical twins will the same patterns be found in the shape of nerve cells or the numbers and configuration of their synapses with other neurons. The microcircuitry of the brain is formatted by influences during the first few years of life, a period when the human brain undergoes astonishingly rapid growth. Five-sixths of the branching of nerve cells in the brain occurs after birth. At times in the first year of life, new synapses are being established at a rate of three billion a second. In large part, each infant’s individual experiences in the early years determine which brain structures will develop and how well, and which nerve centers will be connected with which other nerve centers, and establish the networks controlling behavior. The intricately programmed interactions between heredity and environment that make for the development of the human brain are determined by a “fantastic, almost surrealistically complex choreography,” in the apt phrase of Dr. J. S. Grotstein of the department of psychiatry at UCLA. Attention deficit disorder results from the miswiring of brain circuits, in susceptible infants, during this crucial period of growth.

They basically suggest that specificity allows for a handful of neurons, whose activity is too faint to be measurable, to hypothetically explain lifetimes of complex and coherent experiences. Resuscitation specialist Dr. Sam Parnia’s candid rebuttal of this suggestion seems to frame it best: ‘When you die, there’s no blood flow going into your brain. If it goes below a certain level, you can’t have electric activity. It takes a lot of imagination to think there’s somehow a hidden area of your brain that comes into action when everything else isn’t working.’38 But even if we grant that there is hidden neural activity somewhere, the materialist position immediately raises the question of why we are born with such large brains if only a handful of neurons were sufficient to confabulate unfathomable dreams. After all, as a species, we pay a high price for our large brains in terms of metabolism and in terms of having to be born basically premature, since a more developed head cannot pass through a woman’s birth canal. Moreover, under ordinary conditions, it has been scientifically demonstrated that we generate measurable neocortical activity even when we dream of the mere clenching of a hand!39 It is, thus, incoherent to postulate that undetectable neural firings – the extreme of specificity – are sufficient to explain complex experiences.

In a nutshell, serotonin gives your neurons a thick skin, so they can withstand the pace of the bristling, bustling, neural metropolis. And then along comes a tiny army of LSD molecules, marching out of their Trojan Horse—a small purple tablet—and they look just like serotonin molecules. If you were a receptor site, you wouldn’t be able to tell the difference. Through this insidious trickery, LSD molecules fool the receptors that normally suck up serotonin. They elbow serotonin out of the way and lodge themselves in these receptors instead. They do this in perceptual regions of the cortex, such as the occipital and temporal lobes, in charge of seeing and hearing, and in more cognitive zones, such as the prefrontal cortex, where conscious judgments take place. They do it in brain-stem nuclei that send their messages throughout the brain and body, felt as arousal and alertness. And once they’ve taken up their positions, Troy begins to fall. Not through force, as with the devastating blows of alcohol and dextromethorphan, but through passivity. Once encamped in their serotonin receptors, LSD molecules simply remain passive. They don’t inhibit, they don’t soothe, they don’t regulate, or filter, or modulate. They sit back with evil little grins and say, “It’s showtime! You just go ahead and fire as much as you like. You’re going to pick up a lot of channels you never got before. So have fun. And call me in about eight hours when my shift is over.

Brain function is largely an uncharted territory. But just to get a glimpse of the terrain, however foggy, consider some numbers. The human retina, a thin slab of 100 million neurons that's smaller than a dime and about as thick as a few sheets of paper, is one of the best-studied neuronal clusters. The robotics researcher Hans Moravec has estimated that for a computer-based retinal system to be on a par with that of humans, it would need to execute about a billion operations each second. To scale up from the retina's volume to that of the entire brain requires a factor of roughly 100,000; Moravec suggests that effectively simulating a brain would require a comparable increase in processing power, for a total of about 100 million million (10^14) operations per second. Independent estimates based on the number of synapses in the brain and their typical firing rates yield processing speeds within a few orders of magnitude of this result, about 10^17 operations per second. Although it's difficult to be more precise, this gives a sense of the numbers that come into play. The computer I'm now using has a speed that's about a billion operations per second; today's fastest supercomputers have a peak speed of about 10^15 operations per second ( a statistic that no doubt will quickly date this book). If we use the faster estimate for brain speed, we find that a hundred million laptops, or a hundred supercomputers, approach the processing power of a human brain. Such comparisons are likely naive: the mysteries of the human brain are manifold, and speed is only one gross measure of function.

Dr Joe Dispeza also explains Neuroplasticity in the hit film, What The Bleep do we Know!? Down the Rabbit Hole: The brain does not know the difference between what it sees in its environment, and what it remembers, because the same specific neural nets are firing. The brain is made up of tiny nerve cells called neurons. These neurons have tiny branches that reach out and connect to other neurons to form a neural net. Each place where they connect is integrated into a thought, or a memory. Now, the brain builds up all its concepts by the law of associative memory. For example, ideas, thoughts and feelings are all constructed then interconnected in this neural net, and all have a possible relationship with one another. The concept in the feeling of love, for instance, is stored in the vast neural net, but we build the concept of love from many other different ideas. Some people have love connected to disappointment. When they think about love they experience the memory of pain, sorrow, anger and even rage. Rage maybe linked to hurt, which maybe linked to a specific person, which then is connected back to love. Who is in the driver’s seat when we control our emotions or response to emotion? We know physiologically the nerve cells that fire together, wire together. If you practise something over and over, those nerve cells have a long-term relationship. If you get angry on a daily basis, be it frustrated on a daily basis, if you suffer and give reason for the victimization in your life, you’re rewiring and re-integrating that neural net on a daily basis. That net then has a long-term relationship with all those other nerve cells called an identity. We also know that when nerve cells don’t fire together, they no longer wire together. They lose their long-term relationship, because every time we interrupt the thought process that produces a chemical response, every time we interrupt it, those nerve cells that are connected to each other start breaking their long-term relationship. When we start interrupting and observing, not by stimulus and response to the automatic reaction, but by observing the effects it takes, then we are no longer the body, mind, conscious, emotional person that is responding to its environment as if it is automatic. ‘A life

The message. This was the leap of faith Vittoria was still struggling to accept. Had God actually communicated with the camerlengo? Vittoria’s gut said no, and yet hers was the science of entanglement physics—the study of interconnectedness. She witnessed miraculous communications every day—twin sea-turtle eggs separated and placed in labs thousands of miles apart hatching at the same instant . . . acres of jellyfish pulsating in perfect rhythm as if of a single mind. There are invisible lines of communication everywhere, she thought. But between God and man? Vittoria wished her father were there to give her faith. He had once explained divine communication to her in scientific terms, and he had made her believe. She still remembered the day she had seen him praying and asked him, “Father, why do you bother to pray? God cannot answer you.” Leonardo Vetra had looked up from his meditations with a paternal smile. “My daughter the skeptic. So you don’t believe God speaks to man? Let me put it in your language.” He took a model of the human brain down from a shelf and set it in front of her. “As you probably know, Vittoria, human beings normally use a very small percentage of their brain power. However, if you put them in emotionally charged situations—like physical trauma, extreme joy or fear, deep meditation—all of a sudden their neurons start firing like crazy, resulting in massively enhanced mental clarity.” “So what?” Vittoria said. “Just because you think clearly doesn’t mean you talk to God.” “Aha!” Vetra exclaimed. “And yet remarkable solutions to seemingly impossible problems often occur in these moments of clarity. It’s what gurus call higher consciousness. Biologists call it altered states. Psychologists call it super-sentience.” He paused. “And Christians call it answered prayer.” Smiling broadly, he added, “Sometimes, divine revelation simply means adjusting your brain to hear what your heart already knows.” Now, as she dashed down, headlong into the dark, Vittoria sensed perhaps her father was right. Was it so hard to believe that the camerlengo’s trauma had put his mind in a state where he had simply “realized” the antimatter’s location? Each of us is a God, Buddha had said. Each of us knows all. We need only open our minds to hear our own wisdom.

Cannabinoids relax the rules of cortical crowd control, but 300 micrograms of d-lysergic acid diethylamide break them completely. This is a clean sweep. This is the Renaissance after the Dark Ages. Dopamine—the fuel of desire—is only one of four major neuro modulators. Each of the neuromodulators fuels brain operations in its own particular way. But all four of them share two properties. First, they get released and used up all over the brain, not at specific locales. Second, each is produced by one specialized organ, a brain part designed to manufacture that one potent chemical (see Figure 3). Instead of watering the flowers one by one, neuromodulator release is like a sprinkler system. That’s why neuromodulators initiate changes that are global, not local. Dopamine fuels attraction, focus, approach, and especially wanting and doing. Norepinephrine fuels perceptual alertness, arousal, excitement, and attention to sensory detail. Acetylcholine energizes all mental operations, consciousness, and thought itself. But the final neuromodulator, serotonin, is more complicated in its action. Serotonin does a lot of different things in a lot of different places, because there are many kinds of serotonin receptors, and they inhabit a great variety of neural nooks, staking out an intricate network. One of serotonin’s most important jobs is to regulate information flow throughout the brain by inhibiting the firing of neurons in many places. And it’s the serotonin system that gets dynamited by LSD. Serotonin dampens, it paces, it soothes. It raises the threshold of neurons to the voltage changes induced by glutamate. Remember glutamate? That’s the main excitatory neurotransmitter that carries information from synapse to synapse throughout the brain. Serotonin cools this excitation, putting off the next axonal burst, making the receptive neuron less sensitive to the messages it receives from other neurons. Slow down! Take it easy! Don’t get carried away by every little molecule of glutamate. Serotonin soothes neurons that might otherwise fire too often, too quickly. If you want to know how it feels to get a serotonin boost, ask a depressive several days into antidepressant therapy. Paxil, Zoloft, Prozac, and all their cousins leave more serotonin in the synapses, hanging around, waiting to help out when the brain becomes too active. Which is most of the time if you feel the world is dark and threatening. Extra serotonin makes the thinking process more relaxed—a nice change for depressives, who get a chance to wallow in relative normality.

Dr. Hobson (with Dr. Robert McCarley) made history by proposing the first serious challenge to Freud’s theory of dreams, called the “activation synthesis theory.” In 1977, they proposed the idea that dreams originate from random neural firings in the brain stem, which travel up to the cortex, which then tries to make sense of these random signals. The key to dreams lies in nodes found in the brain stem, the oldest part of the brain, which squirts out special chemicals, called adrenergics, that keep us alert. As we go to sleep, the brain stem activates another system, the cholinergic, which emits chemicals that put us in a dream state. As we dream, cholinergic neurons in the brain stem begin to fire, setting off erratic pulses of electrical energy called PGO (pontine-geniculate-occipital) waves. These waves travel up the brain stem into the visual cortex, stimulating it to create dreams. Cells in the visual cortex begin to resonate hundreds of times per second in an irregular fashion, which is perhaps responsible for the sometimes incoherent nature of dreams. This system also emits chemicals that decouple parts of the brain involved with reason and logic. The lack of checks coming from the prefrontal and orbitofrontal cortices, along with the brain becoming extremely sensitive to stray thoughts, may account for the bizarre, erratic nature of dreams. Studies have shown that it is possible to enter the cholinergic state without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims that meditation, worrying, or being placed in an isolation tank can induce this cholinergic state. Pilots and drivers facing the monotony of a blank windshield for many hours may also enter this state. In his research, he has found that schizophrenics have an unusually large number of cholinergic neurons in their brain stem, which may explain some of their hallucinations. To make his studies more efficient, Dr. Allan Hobson had his subjects put on a special nightcap that can automatically record data during a dream. One sensor connected to the nightcap registers the movements of a person’s head (because head movements usually occur when dreams end). Another sensor measures movements of the eyelids (because REM sleep causes eyelids to move). When his subjects wake up, they immediately record what they dreamed about, and the information from the nightcap is fed into a computer. In this way, Dr. Hobson has accumulated a vast amount of information about dreams. So what is the meaning of dreams? I asked him. He dismisses what he calls the “mystique of fortune-cookie dream interpretation.” He does not see any hidden message from the cosmos in dreams. Instead, he believes that after the PGO waves surge from the brain stem into the cortical areas, the cortex is trying to make sense of these erratic signals and winds up creating a narrative out of them: a dream.

Recently, brain scans of schizophrenics taken while they were having auditory hallucinations have helped explain this ancient disorder. For example, when we silently talk to ourselves, certain parts of the brain light up on an MRI scan, especially in the temporal lobe (such as in Wernicke’s area). When a schizophrenic hears voices, the very same areas of the brain light up. The brain works hard to construct a consistent narrative, so schizophrenics try to make sense of these unauthorized voices, believing they originate from strange sources, such as Martians secretly beaming thoughts into their brains. Dr. Michael Sweeney of Ohio State writes, “Neurons wired for the sensation of sound fire on their own, like gas-soaked rags igniting spontaneously in a hot, dark garage. In the absence of sights and sounds in the surrounding environment, the schizophrenic’s brain creates a powerful illusion of reality.” Notably, these voices seem to be coming from a third party, who often gives the subject commands, which are mostly mundane but sometimes violent. Meanwhile, the simulation centers in the prefrontal cortex seem to be on automatic pilot, so in a way it’s as though the consciousness of a schizophrenic is running the same sort of simulations we all do, except they’re done without his permission. The person is literally talking to himself without his knowledge. HALLUCINATIONS The mind constantly generates hallucinations of its own, but for the most part they are easily controlled. We see images that don’t exist or hear spurious sounds, for example, so the anterior cingulate cortex is vital to distinguish the real from the manufactured. This part of the brain helps us distinguish between stimuli that are external and those that are internally generated by the mind itself. However, in schizophrenics, it is believed that this system is damaged, so that the person cannot distinguish real from imaginary voices. (The anterior cingulate cortex is vital because it lies in a strategic place, between the prefrontal cortex and the limbic system. The link between these two areas is one of the most important in the brain, since one area governs rational thinking, and the other emotions.) Hallucinations, to some extent, can be created on demand. Hallucinations occur naturally if you place someone in a pitch-black room, an isolation chamber, or a creepy environment with strange noises. These are examples of “our eyes playing tricks on us.” Actually, the brain is tricking itself, internally creating false images, trying to make sense of the world and identify threats. This effect is called “pareidolia.” Every time we look at clouds in the sky, we see images of animals, people, or our favorite cartoon characters. We have no choice. It is hardwired into our brains. In a sense, all images we see, both real and virtual, are hallucinations, because the brain is constantly creating false images to “fill in the gaps.” As we’ve seen, even real images are partly manufactured. But in the mentally ill, regions of the brain such as the anterior cingulate cortex are perhaps damaged, so the brain confuses reality and fantasy.

Endrocrine cells have neither dendrites nor axons, but many are like neurons in other ways. Some are electrically exitable: when pancreatic beta cells see an increase in extracellular glucose concentration they fire in bursts of spikes that are like the phasic bursts of vasopressin neurons; these bursts lead to calcium entry and trigger insulin secretion. In both neurons and endocrine cells, peptides are packages in vesicles just as neurotransmitters are. Typically, peptide secretion is the result of the same process as that by which neurotransmitters are released: exocytosis is triggered in both cases by an increase in intracellular calcium. In neurons, this happens when spikes depolarize the neuron, opening voltage-sensitive calcium channels, and the same occurs in spiking endocrine cells. However, endocrine cells have another trick. Th cell bodies of all eukaryotic cells contain rough endoplasmic reticulum, which sequesters free calcium, and activation of receptors for some neurotransmitters or hormones can release calcium from these stores. In many endocrine cells, this 'calcium mobilization' can trigger exocytosis of vesicles without any involvement of spikes. There is no rough endoplasmic reticulum in axon terminals, so spikes are necessarily involved in the release of synaptic vesicles.

Originally, I firmly believed that I would never date a woman with bipolar disorder. Having children with such a woman would increase the likelihood of my children having the illness. I didn’t want that for them, so I wrote off bipolar women. Then I met Delilah, and my prejudice got turned upside-down. She suffered just like me, and I couldn’t have imagined, let alone comprehended, how much that would mean to me. I could feel her suffering, and it pressed against me. One by one, my neurons started to light up and fire to each other. When she was manic, I was enamored by her charm, and when she was depressed, I found her more beautiful than ever. She was a magnet, and I was her polar opposite.

neuroplasticity, the relatively recent discovery that neurons that “fire together, wire together.” When a circuit fires repeatedly, it can become a default setting—the response most likely to occur. If you feel safe and loved, your brain becomes specialized in exploration, play, and cooperation; if you are frightened and unwanted, it specializes in managing feelings of fear and abandonment.

When it comes to the firing of our neurons, it’s a mistake to assume that more is better.

When we watch another human being making a movement, whether it is sticking out a tongue, carrying packages, swerving, dancing, eating, or clapping hands, our neurons fire in the same way, as if we ourselves were making the movement. From the brain's perspective . . . watching is pretty similar to doing. The brain has a built-in empathic and mimicking capacity. It translates what is seen through the eyes into the equivalent of doing and is structured to absorb and prepare itself for what we may not yet have mastered.

Thoughts are electrochemical responses that happen thanks to the firing of neurons in the brain. Thoughts serve a purpose; they allow us to problem solve, create, and form connections.

This understanding is important because it provides a neurological foundation for why deliberate practice works. By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill. The reason, therefore, why it’s important to focus intensely on the task at hand while avoiding distraction is because this is the only way to isolate the relevant neural circuit enough to trigger useful myelination.

Norepinephrine: The Wake-Up Neurotransmitter One of norepinephrine’s effects on the brain is to sharpen attention. As we saw earlier, norepinephrine (aka noradrenaline) can function as both a neurotransmitter and a hormone. When we perceive stress and activate the fight-or-flight response, the brain produces bursts of norepinephrine, triggering anxiety. But sustained and moderate secretion can also produce a beneficial result in the form of heightened attention, even euphoria, and meditation has been shown to produce a rise in norepinephrine in the brain. A modest dose of norepinephrine is also associated with reduced beta brain waves. 5.11. Norepinephrine: your wake-up molecule. Notice the paradox here. Norepinephrine is associated with both anxiety and attentiveness. How do you get enough to be alert, but not so much you’re stressed? Surrender is the key. Steven Kotler, co-author of Stealing Fire, says that stress neurochemicals like norepinephrine actually prime the brain for flow states. At first, the meditator is frustrated by Monkey Mind. But if she surrenders, despite the perpetual self-chatter of the DMN, she enters the next phase of flow, which is focus. She has hacked her biology, using the negative experience of mind wandering as a springboard to flow. Norepinephrine’s molecular structure is similar to its cousin, epinephrine. While epinephrine works on a number of sites in the body, norepinephrine works exclusively on the arteries. When both dopamine and norepinephrine are present in the brain at the same time, they amplify focus. Attention becomes sharp, while perception is enhanced. Staying alert is a key function of the brain’s attention circuit, which keeps you focused on the object of your meditation and counteracts the wandering mind. It also stops you from becoming drowsy, an occupational hazard for meditators. That’s because pleasure neurotransmitters such as serotonin and melatonin (for which serotonin is the precursor) can put you to sleep if not balanced by alertness-producing norepinephrine. Again, the ratios are the key. Oxytocin: The Hug Drug 5.12. Oxytocin: your cuddle molecule. Oxytocin is produced by the hypothalamus, part of the brain’s limbic system. When activated, neurons in the hypothalamus stimulate the pituitary gland to release oxytocin into the bloodstream. So even though oxytocin is produced in the brain, it has effects on the body as well, giving it the status of a hormone. It is one of a group of small protein molecules called neuropeptides. A closely related neuropeptide is vasopressin. All mammals produce some variant of these neuropeptides. Oxytocin promotes bonding between humans. It is responsible for maternal feelings and physically prepares the female body for childbirth and nursing. It is generated through physical touch but also by emotional intimacy. Oxytocin also facilitates generosity and trust within a group. Oxytocin is the hormone associated with the long slow waves of delta. A researcher hooking subjects up to an EEG found that touch stimulated greater amounts of delta, with certain regions of the skin being more sensitive. The biggest effect was produced by tapping the cheek, as we do in EFT. It produced an 800% spike in delta.

There’s only one activity that stimulates the brain to produce all seven at the same time, and that’s the ecstatic state of flow. The shortest way there is deep, alpha-driven meditation. When you blend all seven into a single cocktail, the result is euphoria. Let’s see: What might a combination of the first letters of each drug look like? Serotonin, Oxytocin, Norepinephrine, Dopamine, Anandamide, Nitric oxide, and Beta-endorphin? Just for fun, let’s combine them, and call our cocktail’s special blend SONDANoBe. This is the magic formula that, produced inside our own bodies in the proper ratios, bathes the brain in the chemicals of ecstasy. GETTING HIGH ON YOUR OWN SUPPLY When I meditate, I can feel the moment when each drug in the cocktail kicks in. First, I use EFT tapping and release any and every negative thought, emotion, and energy. This drops my level of cortisol, along with suppressing the high beta brain waves of stress. I now have a molecular substrate in my brain upon which I can build a deep and focused meditative experience. Next, I close my eyes and focus. Dopamine kicks in as I anticipate the delicious hormone and neurotransmitter drug cocktail I’m about to be rewarded with. The dopaminergic reward system of my brain fires up and the “body learning” of how to meditate—stored in my basal ganglia, which memorize frequently performed actions—comes online. Ingredient one. My mind starts to wander. My email inbox. The morning’s first meeting. The laugh line of the movie I watched last night. An overdue deadline. Damn, I’m way out of the zone already, cortisol rising, and I haven’t been meditating more than 5 minutes. Dopamine brings me back to focus, aided by norepinephrine. I’m motivated. I want Bliss Brain more than I want an endless loop of the Me Show. I return to center. Cortisol drops. Ahhh, I’m back. Norepinephrine stimulates my attention. Ingredient two. Then I realize that my body is uncomfortable. I have a twinge in my right knee. My lower back hurts. My tummy’s rumbling because it’s empty. I consciously shift my wandering mind back into focus. Back in sync, my neurons secrete beta-endorphin, which masks the pain. The discomfort drops away, and being in a body feels wonderful. Ingredient three. I tune in to each of the archetypal strands that guide me. Mother Mary. Kwan Yin. Healing. Strength. Beauty. Wisdom. I imagine myself meditating in a field of a million saints. I’m lost in Bliss Brain, as serotonin, the satisfaction drug, kicks in. Ingredient four. I feel one with the universe. Oxytocin starts to flow, as I bond with everything. Ingredient five. That releases nitric oxide and anandamide. Ingredients six and seven.

Emotional self-regulation isn’t just “emotional” in the sense of feelings, such as anger, shame, guilt, and resentment. It’s physical, in the form of bundles of neurons that fire together and wire together, sometimes communicating with distant parts of the brain. Behavior that demonstrates poor emotional self-regulation is the external evidence of the activity of neural pathways deep inside the limbic system. In people who are depressed, the hippocampus shrinks over time. In people with chronic PTSD, high cortisol levels produce calcium deposits on the hippocampus. You want lots of calcium in your bones and teeth. You certainly don’t want it ossifying your brain’s memory and learning center. Conversely, people with effective emotional self-regulation grow a larger hippocampus and much greater volumes of neural tissue in substructures like the dentate gyrus, a part of the hippocampus that coordinates emotional control among different parts of the brain. As happy people practice the emotional regulation required to shift their focus away from random thoughts and the problems of life, they turn states to traits.

Holy crap does smiling make a difference. Smiling makes you feel better. Try it now. I’ll wait… The body is the mind. Neurons fire when you smile. It may not get you out of deep depression, but hell it can help the average joe have a merrier day. The best part is you have complete control over whether you smile or not, and it is absolutely free.

LOCAL SELF AS HOST FOR NONLOCAL SELF When you drop back into your daily life after meditation, you’re changed. You’ve communed with nonlocal mind for an hour, experiencing the highest possible cadence of who you are. That High Self version of you rearranges neurons in your head to create a physical structure to anchor it. You now have a brain that accommodates both the local self and the nonlocal self. My experience has been that the longer you spend in Bliss Brain, whether in or out of meditation, the greater the volume of neural tissue available to anchor that transcendent self in physical experience. Once a critical mass of neurons has wired together, a tipping point occurs. You begin to flash spontaneously into Bliss Brain throughout your day. When you’re idle for a while, like being stuck in traffic or standing in line at the grocery store, the most natural activity seems to be to go into Bliss Brain for a few moments. This reminds you, in the middle of everyday life, that the nonlocal component of your Self exists. It also brings all the enhanced creativity, productivity, and problem-solving ability of Bliss Brain to bear on your daily tasks. You become a happy, creative, and effective person. These enhanced capabilities render you much more able to cope with the challenges of life. They don’t confer exceptional luck. When everyone’s house burns down, yours does too. When the economy nosedives, it takes you with it. But because you possess resilience, and a daily experience of your nonlocal self, you take it in stride. Even when external things vanish, you still have the neural network that Bliss Brain created. No one can take that away from you. DEEPENING PRACTICES Here are practices you can do this week to integrate the information in this chapter into your life: Posttraumatic Growth Exercise 1: In your journal, write down the names of the most resilient people you’ve known personally. They can be alive or dead. They’re people who’ve gone through tragedy and come out intact. Make an appointment to spend time with at least two of the living ones in the coming month. Listen to their stories and allow inspiration to fill you. Neural Reconsolidation Exercise: This week, after a particularly deep meditation, savor the experience. Set a timer and lie down for 15 to 30 minutes. Visualize your synapses wiring together as you deliberately fire them by remembering the deliciousness of the meditation. Choices Exercise: Make 10 photocopies of illustration 7.4, the two doors. Next, analyze in what areas of your environment you often make negative choices. Maybe it’s in online meetings with an annoying colleague at work. Maybe it’s the food choices you make when you walk to the fridge. Maybe it’s the movies you watch on your TV. Tape a copy of the two doors illustration to those objects, such as the monitor, fridge, or TV. This will help you remember, when you’re under stress, that you have a choice.

Becoming defensive or counterattacking simply reinforces the idea that you think these people are wrong and unimportant (and stupid), which amplifies their mirror neuron gap and fuels their fire. When you make a counterintuitive move and encourage them to talk, you do the opposite: You mirror respect and interest, and they feel compelled to send the same message back.

First, after the fast-firing neurons get tired, they take a long nap while previously dormant ones are invigorated, keeping the overall activity distribution the same but with revolving active participants. Second, the rate distributions remain correlated across brain states and across various testing situations, implying that some neurons must work harder than others forever. If you cannot decide, no worries. When I asked many of my colleagues, the majority favored the first option, but some argued in favor of the second, which is correct. Individual neurons maintain their firing rate ranks over days, weeks, and months, as if they sense their own firing outputs and adjust them to a set point customized to each cell.

neurons that fire together wire together.

Culture guides how we process information. Cultures with a strong oral tradition rely heavily on the brain’s memory and social engagement systems to process new learning. Learning will be more effective if processed using the common cultural learning aids—stories, music, and repetition. These elements help build neural pathways and activate myelination. They help neurons fire and wire together in ways that make learning “sticky.” Collectivist cultures use social interactions such as conversation and storytelling as learning aids. Because of society’s history of segregation and unequal educational opportunities, many communities of color continue to use the natural learning modalities in the home and community. As a result, their neural pathways are primed to learn using story, art, movement, and music.

Make it last by staying with it for 5, 10, even 20 seconds; don’t let your attention skitter off to something else. The longer that something is held in awareness and the more emotionally stimulating it is, the more neurons that fire and thus wire together, and the stronger the trace in memory (Lewis 2005).

Words are felt bodily presences. They take up residence in our connective tissue, in the inner sanctum of our cells and the rapid fire of neurons. They await our grasp and their play upon the page. They await our writing, our consideration and gaze. They want to be touched by writing and partake in one form becoming another form, a flesh body shedding a skin for a text body.

By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill.

The other truth is that limbic system trauma has a profound affect on the central nervous system and on brain function, and as a result, it can alter our sensory perception. While complete avoidance of triggers may prevent symptoms temporarily, in the long run, avoidance can actually reinforce the pathological neural pathways that are in play with these conditions. In the “neurons that fire together – wire together” model, every time a specific encounter is avoided out of fear, the threat response to that stimulus is heightened.

During the first five to six weeks post conception, the primitive nervous system is in place (we have a brain at the end of four weeks), and there are about 100,000 neurons firing, so it’s possible that some of the experience before we were attached to our biological mothers is stored in our body and mind. Perhaps, they suggest, in that tiny window, before attaching to an anxious, ambivalent, or unhappy mother, there might be a body memory of safety.

A neuronal firework explodes and a biochemical machine gun starts firing an uninterrupted sequence of thoughts.

Those neurons that fire together wire together. In essence, the more we practice activating particular neural networks, the more easily they are to activate, and the more permanent they become in the brain. In his epistle to the church in Rome, St. Paul suggests that renewal is possible: I urge you, brothers and sisters, in view of God’s mercy, to offer your bodies as a living sacrifice, holy and pleasing to God—this is your true and proper worship. Do not conform to the pattern of this world, but be transformed by the renewing of your mind. Then you will be able to test and approve what God’s will is—his good, pleasing and perfect will. (Romans 12:1-2) It is fair to say that although Paul was not a neuroscientist, he refers here to what we now see through the lens of neuroplasticity. Renewal of the mind, therefore, is not just an abstraction. It means real change in real bodies.

neurons that fire together wire together.

neurons that fire together, wire together’.

Today, as provost of Harvard University, Steve Hyman is mostly engaged in the many political and administrative tasks that come with leading a large institution. But he is a neuroscientist by training, and in 1996 to 2001, when he was the director of the NIMH, he wrote a paper, one both memorable and provocative in kind, that summed up all that had been learned about psychiatric drugs. Titled “Initiation and Adaptation: A Paradigm for Understanding Psychotropic Drug Action,” it was published in the American Journal of Psychiatry, and it told of how all psychotropic drugs could be understood to act on the brain in a common way.46 Antipsychotics, antidepressants, and other psychotropic drugs, he wrote, “create perturbations in neurotransmitter functions.” In response, the brain goes through a series of compensatory adaptations. If a drug blocks a neurotransmitter (as an antipsychotic does), the presynaptic neurons spring into hyper gear and release more of it, and the postsynaptic neurons increase the density of their receptors for that chemical messenger. Conversely, if a drug increases the synaptic levels of a neurotransmitter (as an antidepressant does), it provokes the opposite response: The presynaptic neurons decrease their firing rates and the postsynaptic neurons decrease the density of their receptors for the neurotransmitter. In each instance, the brain is trying to nullify the drug’s effects. “These adaptations,” Hyman explained, “are rooted in homeostatic mechanisms that exist, presumably, to permit cells to maintain their equilibrium in the face of alterations in the environment or changes in the internal milieu.” However, after a period of time, these compensatory mechanisms break down. The “chronic administration” of the drug then causes “substantial and long-lasting alterations in neural function,” Hyman wrote. As part of this long-term adaptation process, there are changes in intracellular signaling pathways and gene expression. After a few weeks, he concluded, the person’s brain is functioning in a manner that is “qualitatively as well as quantitatively different from the normal state.” His was an elegant paper, and it summed up what had been learned from decades of impressive scientific work. Forty years earlier, when Thorazine and the other first-generation psychiatric drugs were discovered, scientists had little understanding of how neurons communicated with one another. Now they had a remarkably detailed understanding of neurotransmitter systems in the brain and of how drugs acted on them. And what science had revealed was this: Prior to treatment, patients diagnosed with schizophrenia, depression, and other psychiatric disorders do not suffer from any known “chemical imbalance.” However, once a person is put on a psychiatric medication, which, in one manner or another, throws a wrench into the usual mechanics of a neuronal pathway, his or her brain begins to function, as Hyman observed, abnormally.

Thus the nerve may be taken to be a relay with essentially two states of activity: firing and repose. Leaving aside those neurons which accept their messages from free endings or sensory end organs, each neuron has its message fed into it by other neurons at points of contact known as synapses. For a given outgoing neuron, these vary in number from a very few to many hundred. It is the state of the incoming impulses at the various synapses, combined with the antecedent state of the outgoing neuron itself, which determines whether it will fire or not. If it is neither firing nor refractory, and the number of incoming synapses which “fire” within a certain very short fusion interval of time exceeds a certain threshold, then the neuron will fire after a known, fairly constant synaptic delay. This is perhaps an oversimplification of the picture: the “threshold” may not depend simply on the number of synapses but on their “weight” and their geometrical relations to one another with respect to the neuron into which they feed; and there is very convincing evidence that there exist synapses of a different nature, the so-called “inhibitory synapses,” which either completely prevent the firing of the outgoing neuron or at any rate raise its threshold with respect to stimulation at the ordinary synapses. What is pretty clear, however, is that some definite combinations of impulses on the incoming neurons having synaptic connections with a given neuron will cause it to fire, while others will not cause it to fire. This is not to say that there may not be other, non-neuronic influences, perhaps of a humoral nature, which produce slow, secular changes tending to vary that pattern of incoming impulses which is adequate for firing.

Then there are “virtual organs”—feelings (courage, anger, desire) and the phenomenal experience of seeing colored objects or hearing music or having a certain episodic memory. The immune response, which is realized only when needed, is another example of a virtual organ: For a certain time, it creates special causal properties, has a certain function, and does a job for the organism. When the job is done, it disappears. Virtual organs are like physical organs in that they fulfill a specific function; they are coherent assemblies of functional properties that allow you to do new things. Though part of a behavioral repertoire on the macro level of observable traits, they can also be seen as composed of billions of concerted micro-events—immune cells or neurons firing away. Unlike a liver or a heart, they are realized transiently.

your brain has around 100 billion neurons, averaging around 5’000 connections each, which is similar to having 500 trillion microprocessors wired up together in a single network. The potential combinations of these neurons firing or not, is at least 10 to the millionth power – more than all the atoms in the known universe.

She looked out over the lines of Fjerdan soldiers. She could hear their hearts beating. She could see their neurons firing, feel their impulses forming. Everything made sense. Their bodies were a map of cells, a thousand equations, solved by the second, by the millisecond, and she knew only answers.

When we experience any event, a unique network of neurons is activated depending on the nature of the event. Watching a sunset? Visual centers that represent shadows and light, pink, orange, and yellow are activated. That same sunset a half hour earlier or later looks different, and so invokes correspondingly different neurons for representing it. Watching a tennis game? Neurons fire for face recognition for the players, motion detection for the movements of their bodies, the ball, the rackets, while higher cognitive centers keep track of whether they stayed in bounds and what the score is. Each of our thoughts, perceptions, and experiences has a unique neural correlate—if it didn’t, we would perceive the events as identical; it is the difference in neuronal activations that allows us to distinguish events from one another.

Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn’t it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain? Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don’t want to go to Montana. How do I know I really want to go and it isn’t just some neurons firing or something? Maybe it’s just an accidental flash in the medulla and suddenly there I am in Montana and I find out I really didn’t want to go there in the first place. I can’t control what happens in my brain, so how can I be sure what I want to do ten seconds from now, much less Montana next summer? It’s all this activity in the brain and you don’t know what’s you as a person and what’s some neuron that just happens to fire or just happens to misfire. Isn’t that why Tommy Roy killed those people?

But Kandel’s safety-conditioned mice barge right out into the middle of open space when they hear those beeps that they’ve learned to associate with the absence of immediate danger. Boldly going where no mouse has gone before, they wander much farther afield in a bout of what Kandel calls “adventurous exploration.” What makes these mice turn lion-hearted? When safety-conditioned mice hear the series of beeps, neurons in the caudoputamen—a part of the mouse brain similar to our caudate area—go into overdrive, firing at nearly three times their normal intensity. At the same time, neurons in the amygdala—a fear center in the mouse brain, as it is in ours—quiet down. It’s as if the perception of safety leads to a feeling of mastery over the environment, numbing the brain’s ability to be afraid. No wonder investors take more risk when their own gains fool them into thinking the market has gotten safer.

A precise time provides a cue for the brain that will hasten the “neurons-that-fire-together-wire-together” process.

Rate of myelination in different brain areas The various brain areas begin and end myelination at different ages. For example, visual areas finish myelinating by six months. At that age an infant can see an object moving through space as a homogeneous object; before that, it’s just a collection of disconnected colors and edges. Watch babies wave a toy back and forth in front of their eyes. This rehearsal wires up the visual areas so they can begin to recognize and track objects. Over and over, the same groups of neurons fire together, forming visual functional groups that eventually work together well enough to let the baby recognize familiar objects. Babies’ other senses work along with sight to help form a mental image of objects. Here’s one study that continues to astonish me every time I think about it: Newborns, still in the hospital, were given pacifiers to suck. There were several different shapes: square, round, pointed. Large models of all the different-shaped pacifiers were hung above their cribs. The babies stared longest at the pacifier that matched the one that had been in their mouth. These infants appeared able to relate the mental image created with touch — what was in their mouths — with the one created with vision — what was dangling above their heads. I remember the first time our oldest daughter saw a book. She was about three months old — barely able to sit up — and we put a cardboard book with very simple pictures of toys in front of her. Instantly she put her face right above the book, and she inspected every square inch of the page from about an inch away. Then she sat back up and slapped the pages all over. We could almost see her brain working: “What is this? It’s flat but it reminds me a lot of the things I see around me.” She combined the senses of touch and sight together to examine a new phenomenon in her world. Speech begins with babbling at around six months of age. I remember our youngest daughter beginning speech by mimicking the up and down flow of the sentence before she began to make individual sounds. The flow of speech is supported by language centers in the right hemisphere; the details of speech are supported by language centers in the left hemisphere. Our daughter was practicing how to talk, using the brain areas that were currently available. Her right hemisphere appeared to mature before her left hemisphere. As the speech areas develop and these groups become more extensively coordinated, the child’s speech becomes clearer and connected. The auditory areas finish myelinating by two years. The child now has the brain foundation for speech production. She can distinguish the individual sounds that make up words, and can begin to string words together into phrases and sentences. The motor system is myelinated by four years. Before that, children are very slow to respond. Have you ever played catch with a three-year-old? He holds out his arms, the ball hits his chest, it falls on the ground — and then he closes his arms. It takes so long for the message to move from his eyes to his brain, from his brain to the spinal cord, and finally from his spinal cord to his arms, that he misses the ball. You can practice with him all you like, but his reactions won’t speed up until his motor system myelinates.

My 2005 calculations in The Singularity Is Near noted 1016 operations per second as an upper bound on the brain’s processing speed (as we have on the order of 1011 neurons with on the order of 103 synapses each firing on the order of 102 times per second).[

Learning can be draining. The average adult human brain weighs only about three pounds, but it’s an energy hog, consuming an inordinate amount of glucose, oxygen, and blood flow. As the brain takes in new information, millions of neurons are firing at once, burning energy and leading to fatigue and exhaustion.

neurons that fire together wire together.

Neurons are firing left and right, attempting to psychoanalyze the psycho.

This understanding is important because it provides a neurological foundation for why deliberate practice works. By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill. The reason, therefore, why it’s important to focus intensely on the task at hand while avoiding distraction is because this is the only way to isolate the relevant neural circuit enough to trigger useful myelination. By

Learning to like something new takes longer than you’d think, however. Your brain doesn’t see it as important information if it doesn’t trigger your happy chemicals. And new things are hard to focus on because the neurons don’t fire easily. Here’s a simple example. Fred wants to drink less alcohol. He decides to substitute a new pleasure with fewer side effects. He looks around for something that can grow on him and remembers how he enjoyed sketching when he was young. He resolves to take out his sketch pad every time he feels like drinking. Fred doesn’t actually feel like sketching when he longs for a drink. And once he starts sketching, he doesn’t feel fabulous. So he accepts that he will live with bad feelings for a while. He plans to do this for two months because he has a big event on the calendar then. At first, he finds it hard. He hates his sketches and he hates the feeling he gets when he doesn’t drink. But he sticks to his goal of repeating the strategy whether it feels good immediately or not. After a while, Fred learns to see the sketching time as a gift he’s given himself rather than an extra burden on his already hard life. He learns that his unhappy feelings pass without killing him, and once they’ve passed, he discovers the pleasure of being alert and responsible. Before the two months is over, he stops looking at the calendar. His sketching circuit has grown as big as his alcohol circuit.Now, he’s a healthy person with a fun hobby and a cool skill, not a person at war with himself

When someone is told to speak, the area of the left temporal cortex is flushed with blood. Knowing that astrocytes, not neurons, have their end feet on the blood vessels, it is possible that astrocytes signal to neurons to fire to move the tongue in specific manner for speaking while also controlling blood flow to oxygenate themselves and neurons in the area. As sodium goes in the cell, neurons need oxygen in their mitochondria in order to produce the energy they need to pump out the sodium.

astrocytes, and Myron’s discus thrower was using his neurons. For the astrocyte to be the root of thought, it must be able to process sensory information coming from neurons. It must also be able to communicate to motor neurons to stimulate action. In the peripheral nerves, electrical impulses rapidly fire through sodium and potassium exchange to the muscles to cause contraction, electrical impulses we know as “action potentials.” Action potentials also carry information pertaining to sensory input from the body to the brain.

Even now, when I imagine Einstein’s dendrites and neurons firing as his brain lit upon relativity, I picture Baghdad, with its minarets and modern-antennaed buildings sparkling beneath thousands of phantasmagorical tracers, under Allied attack on a very dark night.

I'm not into IQ tests. Mine has been dropping steadily for years! Is our intelligence really dependent on how fast our neurons fire? Given time, just about anyone could get an IQ of 200.

A half century after Nidetch’s Mallomar binges, scientists had developed a technology that could see cravings erupting, like solar flares, inside the human brain. In early 2008, a research team at the Lewis Center for Neuroimaging at the University of Oregon measured just such a craving in a nineteen-year-old college student we will call Debbie. Debbie had her head inside a very large, very expensive round magnet called an MRI scanner when an image of a chocolate milk shake was flashed before her eyes for two seconds. As soon as Debbie saw it, certain parts of her brain became “activated,” which is to say they drew in lots of blood as millions of neurons were fired. These regions—the left medial orbitofrontal cortex, anterior cingulate cortex, and three other small, curly pockets of gray matter—are all associated with “motivation.” And the functional MRI (fMRI) showed them glowing a bright yellowy orange, like coals in a hot fire, indicating those parts of her brain were churning through quite a lot of blood. She was experiencing “incentive salience,” the scientific term for a Frankenstein craving, or a heightened state of “wanting.” Debbie got what she wanted.

Twenty years after that first recording in the laboratory, a cascade of well-controlled experiments with monkeys and later with humans (different kinds of experiments, for the most part; no needles inserted through skulls) have confirmed the remarkable phenomenon. The simple fact that a subset of the cells in our brains—the mirror neurons—fire when an individual kicks a soccer ball, sees a ball being kicked, hears a ball being kicked, and even just says or hears the word “kick” leads to amazing consequences and new understandings. THE FAB FOUR We now know that about 20 percent of the cells in area F5 of the macaque brain are mirror neurons; 80 percent are not.

What happens in your mind changes your brain, both temporarily and in lasting ways; neurons that fire together wire together.

The human brain operates electro-chemically. Each neuron can fire, carrying an input/output signal 100 times a second. Each neuron has roughly 10,000 connections. There are roughly 100 billion neurons. It adds up to a full capacity of ten to the seventeenth power, but since humans don’t run their brains at full capacity, ten to the sixteenth power is likely a better estimate, albeit a rough one.

In a naive accounting, speaking seems to cost almost nothing—just the calories we expend flexing our vocal cords and firing our neurons as we turn thoughts into sentences. But this is just the tip of the iceberg. A full accounting will necessarily include two other, much larger costs: 1.The opportunity cost of monopolizing information. As Dessalles says, “If one makes a point of communicating every new thing to others, one loses the benefit of having been the first to know it.”11 If you tell people about a new berry patch, they’ll raid the berries that could have been yours. If you show them how to make a new tool, soon everyone will have a copy and yours won’t be special anymore. 2.The costs of acquiring the information in the first place. In order to have interesting things to say during a conversation, we need to spend a lot of time and energy foraging for information before the conversation.12 And sometimes this entails significant risk. Consider the explorer who ventures further than others, only to rush home and broadcast her hard-won information, rather than keeping it for herself. This requires an explanation.

Why Does Mirroring Work? Scientific research suggests ‘mirroring’ techniques works because of the mirror-neurons which are fired in our brains when we both perceive and take action. When we observe someone doing something, we may feel as if we are having the same experience.

Escitalopram is at least 100-fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake and inhibition of 5-HT neuronal firing rate.

In chapter 3, “Redesigning the Brain,” we learned two key laws of plasticity that also underlie this treatment. The first is that Neurons that fire together wire together. By doing something pleasurable in place of the compulsion, patients form a new circuit that is gradually reinforced instead of the compulsion. The second law is that Neurons that fire apart wire apart. By not acting on their compulsions, patients weaken the link between the compulsion and the idea it will ease their anxiety. This delinking is crucial because, as we’ve seen, while acting on a compulsion eases anxiety in the short term, it worsens OCD in the long term. Schwartz

Neurons that fire together, wire together. Neurons that fail to link, fire out of sync.

Each neuron acts in an essentially unpredictable fashion. When an entire network of neurons receives input (from the outside world or from other networks of neurons), the signaling among them appears at first to be frenzied and random. Over time, typically a fraction of a second or so, the chaotic interplay of the neurons dies down and a stable pattern of firing emerges.

In some medical circles, the neurons in the brain that control our body language are called Monkey See - Monkey Do neurons. The study that discovered these neurons was done in 1996, by the Italian researchers Vittorio Gallese and Giacomo Rizzolatti. These neurons are the nerve cells that control our muscles. They don’t react only when we make a movement, but when other people make a movement also. They fire up, even when we see that other people are about to make a certain body movement. That is why it’s important to observe confident people,

The number of possible combinations of 100 billion neurons firing or not is approximately 10 to the millionth power, or 1 followed by a million zeros, in principle; this is the number of possible states of your brain. To put this quantity in perspective, the number of atoms in the universe is estimated to be “only” about 10 to the eightieth power.

I look at that woman and all my neurons start firing at once,” Devlin said. “My head shuts down and that’s not the worst of it.” But he wasn’t about to describe the effect she had on his body. Even if the stallion was looking particularly supportive. The memory of A.J. in his arms was potent enough without adding to it the power of words. “What the hell am I going to do?” If the stallion had an answer, he wasn’t sharing, and Devlin pulled away from the stall with a frustrated groan. “To top it off, she’s got me turning to a horse for advice.

Neurons that fire together wire together.” What this means in terms of memory is that the more intense the activity is between neurons constituting your memory of any given event, the more robust the memory will

Mirror neurons fire for something as simple as drinking water and as complex as yelling in anger. When you watch someone else get angry, stress hormones such as adrenaline and cortisol start to flow. You may not always manage stress the way you hope to, but the very fact that you are working on it will benefit your children.

However, the most interesting property of your spacetime tube isn't its bulk shape, but its internal structure, which is remarkably complex. Whereas the particles that constitute the Moon are stuck together in a rather static arrangement, many of your particles are in constant motion relative to one another. Consider, for example, the particles that make up your red blood cells. As your blood circulates through your body to deliver the oxygen you need, each red blood cell traces out its own unique tube shape through spacetime, corresponding to a complex itinerary through your arteries, capillaries and veins with regular returns to your heart and lungs. These spacetime tubes of different red blood cells are intertwined to form a braid pattern (Figure 11.4, middle panel) which is more elaborate than anything you'll ever see in a hair salon: whereas a classic braid consists of three strands with perhaps thirty thousand hairs each, intertwined in a simple repeating pattern, this spacetime braid consists of trillions of strands (one for each red blood cell), each composed of trillions of hairlike elementary-particle trajectories, intertwined in a complex pattern that never repeats. In other words, if you imagine spending a year giving a friend a truly crazy hairdo, braiding his hair by separately intertwining not strands but all the individual hairs, the pattern you'd get would still be very simple in comparison. Yet the complexity of all this pales in comparison to the patterns of information processing in your brain. As we discussed in Chapter 8 and illustrated in Figure 8.7, your roughly hundred billion neurons are constantly generating electric signals ("firing"), which involves shuffling around billions of trillions of atoms, notably sodium, potassium and calcium ions. The trajectories of these atoms form an extremely elaborate braid through spacetime, whose complex intertwining corresponds to storing and processing information in a way that somehow gives rise to our familiar sensation of self-awareness. There's broad consensus in the scientific community that we still don't understand how this works, so it's fair to say that we humans don't yet fully understand what we are. However, in broad brushstrokes, we might say this: You're a pattern in spacetime. A mathematical pattern. Specifically, you're a braid in spacetime-indeed one of the most elaborate braids known.

The monoamine neurotransmitters, or modulators, as they are often called, are like volume buttons in the brain. Neurons “talk” to each other by releasing tiny molecules called neurotransmitters into clefts between them called synapses. The signaling neuron releases a packet of transmitters, which can then lock into receptors on the receiving neuron, altering that neuron’s behavior. Then the transmitters are broken down or transported back inside the signaling neuron. The two most important neurotransmitters are glutamate and GABA. Glutamate is excitatory, meaning that when it’s released and encounters a receptor, it encourages that second neuron to “fire” and send its own neurotransmitters to still more neurons. GABA is the chief inhibitory neurotransmitter, meaning that it tells neurons not to fire. Without it, the brain would go haywire.

Hebb’s rule, as it has come to be known, is the cornerstone of connectionism. Indeed, the field derives its name from the belief that knowledge is stored in the connections between neurons. Donald Hebb, a Canadian psychologist, stated it this way in his 1949 book The Organization of Behavior: “When an axon of cell A is near enough cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased.” It’s often paraphrased as “Neurons that fire together wire together.

Emotions, particularly strong emotions in people we care about, are contagious. But just as so-called negative emotions are contagious, so are calming and compassionate ones. [...] Mirror neurons in the brain are what cause us to feel the experiences and emotions of people around us. In the classic example, if I am watching you eat a banana, the neurons in my brain that are involved in eating bananas begin to fire. Likewise, if I am sitting across from you and feeling sad or angry, you are likely to have those neurons fire in your brain as well; thus you are *feeling* those emotions yourself, not just detecting them.

And in the brain, neurons that fire together quite literally wire together.

two key preconditions become clear. First, the sheer size of the network: you can’t have an epiphany with only three neurons firing.

Reflexes depend on the speed with which your neurons fire impulses, as well as the speed with which your muscles respond to those impulses.

Plaster holo screens against a mountain a full kilometer high, covering it until it glitters with a half million dancing images. Each holo used a quarter of a million pixels to shape its image, so the array musters immense representational power. Now compress those screens on a sheet of aluminum foil a millimeter thick. Crumple it. Stuff it into a grapefruit. That is the brain, a hundred billion neurons firing at varying intensities. Nature had accomplished that miracle,

The frequency of these brain waves has been crudely correlated with states of consciousness. Delta waves (0.5 to 3 cycles per second) indicate deep sleep. Theta waves (4 to 8 cycles per second) indicate trance, drowsiness, or light sleep. Alpha waves (8 to 14 cycles per second) appear during relaxed wakefulness or meditation. And beta waves (14 to 35 cycles per second), the most uneven forms, accompany all the modulations of our active everyday consciousness. Underlying these rhythms are potentials that vary much more slowly, over periods as long as several minutes. Today's EEG machines are designed to filter them out because they cause the trace to wander and are considered insignificant anyway. There's still no consensus as to where the EEG voltages come from. They would be most easily explained by direct currents, both steady state and pulsing, throughout the brain, but that has been impossible for most biologists to accept. The main alternative theory, that large numbers of neurons firing simultaneously can mimic real electrical activity, has never been proven.

In the mid-1990s, at Duke University, Miguel Nicolelis and John Chapin began a behavioral experiment, with the goal of learning to read an animal’s thoughts. They trained a rat to press a bar, electronically attached to a water-releasing mechanism. Each time the rat pressed the bar, the mechanism released a drop of water for the rat to drink. The rat had a small part of its skull removed, and a small group of microelectrodes were attached to its motor cortex. These electrodes recorded the activity of forty-six neurons in the motor cortex involved in planning and programming movements, neurons that normally send instructions down the spinal cord to the muscles. Since the goal of the experiment was to register thoughts, which are complex, the forty-six neurons had to be measured simultaneously. Each time the rat moved the bar, Nicolelis and Chapin recorded the firing of its forty-six motor-programming neurons, and the signals were sent to a small computer. Soon the computer “recognized” the firing pattern for bar pressing. After the rat became used to pressing the bar, Nicolelis and Chapin disconnected the bar from the water release. Now when the rat pressed the bar, no water came. Frustrated, it pressed the bar a number of times, but to no avail. Next the researchers connected the water release to the computer that was connected to the rat’s neurons. In theory, now, each time the rat had the thought “press the bar,” the computer would recognize the neuronal firing pattern and send a signal to the water release to dispense a drop. After a few hours, the rat realized it didn’t have to touch the bar to get water. All it had to do was to imagine its paw pressing the bar, and water would come! Nicolelis and Chapin trained four rats to perform this task.

Amid great anticipation, Giacomo slowly lowered the electrode into the callosum. As is commonly done in neurophysiology, the recording system was hooked up to a loudspeaker so that the rat-tat-tat of the neurons firing could be heard. We were ready to hear the Morse code of the brain. Then it happened. The electrode pierced the callosum. Instead of the rat-tat-tat we expected, the loudspeaker boomed with the excruciatingly clear voice of Ringo Starr singing, “We all live in a yellow submarine, a yellow submarine, a yellow submarine.” Giacomo looked up from the cat and calmly said, “Now that is what I call high-order information.” Some kind of electronic ground loop had been closed, and we were picking up the local radio station. We all laughed, though we knew this brain code thing was going to be a long haul.

When neurons fire together, they exchange charged elements that then produce electromagnetic fields, and these fields are what are measured during a brain scan (like an electroencephalograph, or EEG). Humans have several measurable brain-wave frequencies, and the slower the brain-wave state we’re in, the deeper we go into the inner world of the subconscious mind.

This discovery led to an important question. How does the brain make predictions? One potential answer is that the brain has two types of neurons: neurons that fire when the brain is actually seeing something, and neurons that fire when the brain is predicting it will see something. To avoid hallucinating, the brain needs to keep its predictions separate from reality. Using two sets of neurons does this nicely. However, there are two problems with this idea.

Remember: the neurons that fire together wire together, so you can reroute and redeem your thinking patterns.

When zebra finches are raised by Bengalese finch foster parents, the juvenile birds retains the silent gaps characteristic of zebra finch song patterns, which is distinct from the shorter gaps of the Bengalese song. Thus, the syntactic rules are genetically inherited species-specific patterns, just like brain rhythms in mammals, whereas the variable content of the syllables and words can be acquired by experience. The pattern and content are processed by dissociable neuronal circuits in the bird's brain. In the auditory cortex, slow-firing neurons are mainly sensitive to the acoustic features, such as timbre and pitch. In contrast, faster firing, possible inhibitory, neurons encode the silent gaps and rhythm of the song, and they are insensitive to acoustic features. This division of labor between the inherited temporal patterns that serve as the syntax and the flexible content may be similar to the way human speech is organized.

Kids whose parents talk to them about their feelings also develop a more robust emotional intelligence and can therefore be better at noticing and understanding their own and other people’s feelings. Neurons that fire together wire together, changing the changeable brain.