Neural Quotes

But if you tell folks you're a college student, folks are so impressed. You can be a student in anything and not have to know anything. Just say toxicology or marine biokinesis, and the person you're talking to will change the subject to himself. If this doesn't work, mention the neural synapses of embryonic pigeons.

So, attend carefully to your posture. Quit drooping and hunching around. Speak your mind. Put your desires forward, as if you had a right to them—at least the same right as others. Walk tall and gaze forthrightly ahead. Dare to be dangerous. Encourage the serotonin to flow plentifully through the neural pathways desperate for its calming influence.

The butterfly's wing beat of love can engender a mystical attraction in the neural meanders of our mind and generate emotional torments with a single stroke. ("I seek you")

When we dare to think differently and decide to expand our thinking, we instill fresh energy in our drained mindset. By infusing new life into our neural web, we create inner space in our journey to self-knowledge and deeper insight.( "Lost dreams")

When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate — the genetic and neural fate — of every human being to be a unique individual, to find his own path, to live his own life, to die his own death.

Relationships may become wrecked by a quirky syndrome: the “Ain't broke, don't fix”-syndrome. When there is no interaction in the neural network and no breakthrough into the mind but only a shallow skin experience, living together might be very torturous. If a heartfelt bond has not been molded, nothing can be broken and thus nothing needs to be fixed. (“I wonder what went wrong.”)

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.

Yeah, I'll just code a patch to stop feeling anxiety, wow, why didn't I think of that earlier. (That was sarcasm, I have too much organic neural tissue for that to work.) (Of course I've already tried it.)

After a fairly shaky start to the day, Arthur's mind was beginning to reassemble itself from the shell-shocked fragments the previous day had left him with. He had found a Nutri-Matic machine which had provided him with a plastic cup filled with a liquid that was almost, but not quite, entirely unlike tea. The way it functioned was very interesting. When the Drink button was pressed it made an instant but highly detailed examination of the subject's taste buds, a spectroscopic analysis of the subject's metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject's brain to see what was likely to go down well. However, no one knew quite why it did this because it invariably delivered a cupful of liquid that was almost, but not quite, entirely unlike tea.

I don't want five hundred billion neural chips. I want guts.

the mind is a neural computer

For my part, I think we need more emotion, not less. But I think, too, that we need to educate people in how to feel. Emotionalism is not the same as emotion. We cannot cut out emotion - in the economy of the human body, it is the limbic, not the neural, highway that takes precedence. We are not robots...but we act as though all our problems would be solved if only we had no emotions to cloud our judgement.

There will be no one like us when we are gone, but then there is no one like anyone else, ever. When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate—the genetic and neural fate—of every human being to be a unique individual, to find his own path, to live his own life, to die his own death. I cannot pretend I am without fear. But my predominant feeling is one of gratitude. I have loved and been loved; I have been given much and I have given something in return; I have read and traveled and thought and written. I have had an intercourse with the world, the special intercourse of writers and readers. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure.

Imagine for a moment that we are nothing but the product of billions of years of molecules coming together and ratcheting up through natural selection, that we are composed only of highways of fluids and chemicals sliding along roadways within billions of dancing cells, that trillions of synaptic conversations hum in parallel, that this vast egglike fabric of micron-thin circuitry runs algorithms undreamt of in modern science, and that these neural programs give rise to our decision making, loves, desires, fears, and aspirations. To me, that understanding would be a numinous experience, better than anything ever proposed in anyone's holy text.

The neural processes underlying that which we call creativity have nothing to do with rationality. That is to say, if we look at how the brain generates creativity, we will see that it is not a rational process at all; creativity is not born out of reasoning.

When we get business networks to function similarly to neural networks and mycelium networks, we'll have a better world.

Where attention goes, neural firing flows, and neural connection grows.

If you want your tree to produce plenty o' fruit, you've got to cut it back from time to time. Same thing with your neural cells. Some people might call it brain damage. I call it prunin'.

You will not die of pain, but you will never get used to it. Pain is unique in that it does not show habituation or neural adaptation, like smell, or touch.

The key question is, no matter how much you absorb of another person, can you have absorbed so much of them that when that primary brain perishes, you can feel that that person did not totally perish from the earth... because they live on in a 'second neural home'?... In the wake of a human being's death, what survives is a set of afterglows, some brighter and some dimmer, in the collective brains of those who were dearest to them... Though the primary brain has been eclipsed, there is, in those who remain... a collective corona that still glows.

By taking just a few extra seconds to stay with a positive experience—even the comfort in a single breath—you’ll help turn a passing mental state into lasting neural structure.

Around Mik, my powers desert me. I lose basic motor function, like my brain focuses all neural activity on my lips and shifts into kiss preparedness mode way too early, to the detriment of things like speech, and walking.

Neurons that fire together wire together. Mental states become neural traits. Day after day, your mind is building your brain. This is what scientists call experience-dependent neuroplasticity,

Make no mistake: E-mail, Facebook, and Twitter checking constitute a neural addiction.

Posthuman. It was a word that came up in the media every five or six years, and it meant different things every time. Neural regrowth hormone? Posthuman. Sex robots with inbuilt pseudo intelligence? Posthuman. Self-optimizing network routing? Posthuman. It was a word from advertising copy, breathless and empty, and all he’d ever thought it really meant was that the people using it had a limited imagination about what exactly humans were capable of.

Here are three separate but similar things: shyness, introversion and social anxiety. You can have one, two or all three of these things simultaneously. A lot of the time people thing they're all the same thing, but that's just not true. Extroverts can be shy, introverts can be bold, and a condition like anxiety can strike whatever kind of social animal you are. Lots of people are shy. Shy is normal. A bit of anxiety is normal. Throw the two together, add some brain-signal error - a NO ENTRY sign on the neural highway from my brain to my mouth perhaps, though no one really knows - and you have me.

It takes an intellectual and physical effort to shove aside the comfortably worn neural pathways and go in a different direction.

It should be reassuring that humans don’t get what other humans are thinking, either, but it just highlights how fucked up human neural tissue can be.

Multitasking means that you are not able to make full, rich connections in your thinking, because the part of your brain that helps make connections is constantly being pulled away before neural connections can be firmed up.

As modern-day neuroscience tells us, we are never in touch with the present, because neural information-processing itself takes time. Signals take time to travel from your sensory organs along the multiple neuronal pathways in your body to your brain, and they take time to be processed and transformed into objects, scenes, and complex situations. So, strictly speaking, what you are experiencing as the present moment is actually the past.

It is this potential for plasticity of the relatively stereotyped units of the nervous system that endows each of us with our individuality.

Every time you take in the good, you build a little bit of neural structure. Doing this a few times a day—for months and even years—will gradually change your brain, and how you feel and act, in far-reaching ways.

Loss of someone we love cannot be adequately expressed with words. Grappling with loss, struggling with disconnection and despair, fills us with a sense of anguish and actual pain. Indeed, the parts of our brain that process physical pain overlap with the neural centers that record social ruptures and rejection. Loss rips us apart.

Quantum coherence in the ion channels of the neurons and the neural circuits in the brain creates the decision behaviors and quantum cognition.

For more than 2 million years, human neural networks kept growing and growing, but apart from some flint knives and pointed sticks, humans had precious little to show for it. What then drove forward the evolution of the massive human brain during those 2 million years? Frankly, we don’t know.

There will be no one like us when we are gone, but then there is no one like anyone else, ever. When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate—the genetic and neural fate—of every human being to be a unique individual, to find his own path, to live his own life, to die his own death.

As advances in AI, machine learning, and neural networks evolve, incomprehensibility will reach even higher levels - exposing these complex systems to both human and machine errors.

Just as breathing exercises help integrate body and mind, writing is a kind of psycho-neural muscular activity which helps bridge and integrate the conscious and subconscious minds. Writing distills, crystallizes, and clarifies thought and helps break the whole into parts.

How can you be sure?" "I'm a doctor, Jenna. And a scientist." "Does that make you an authority on everything? What about a soul, Father? When you were so busy implanting all your neural chips, did you think about that? Did you snip my soul from my old body, too? Where did you put it? Show me! Where? Where in all this groundbreaking technology did you insert my soul?

Our surmises regarding the subtle functions of neural processes within the brain are profoundly constrained by the fact that the brain did not evolve in order to understand itself. The complex organization of the brain evolved as a consequence of our sensorial and muscled engagement with the landscapes that surround us.

Skill is a cellular insulation that wraps neural circuits and that grows in response to certain signals.

When you realize that quantum mechanics underlies all physical processes, from the fusing of atoms in the sun to the neural firings that constitutes the stuff of thought, the far-reaching implications of the proposal become apparent. It says that there’s no such thing as a road untraveled. Yet each such road—each reality—is hidden from all others.

NirVana chakra is the chakra of neuroplasticity. It allows the brain to continuously change and adapt, and build new neural connections as needed, and abandoning the pathways that drags people down.

What is human memory?" Manning asked. He gazed at the air as he spoke, as if lecturing an invisible audience - as perhaps he was. "It certainly is not a passive recording mechanism, like a digital disc or a tape. It is more like a story-telling machine. Sensory information is broken down into shards of perception, which are broken down again to be stored as memory fragments. And at night, as the body rests, these fragments are brought out from storage, reassembled and replayed. Each run-through etches them deeper into the brain's neural structure. And each time a memory is rehearsed or recalled it is elaborated. We may add a little, lose a little, tinker with the logic, fill in sections that have faded, perhaps even conflate disparate events. "In extreme cases, we refer to this as confabulation. The brain creates and recreates the past, producing, in the end, a version of events that may bear little resemblance to what actually occurred. To first order, I believe it's true to say that everything I remember is false.

And in its broadest sense, neural Darwinism implies that we are destined, whether we wish it or not, to a life of particularity and self-development, to make our own individual paths through life.

There is a tension between what is good for someone and what they want to do. This is because people, especially older people, like to do things as they've always done them. The problem is that when the brain develops ingrained habits, it doesn't need to think anymore. Things get done very quickly and efficiently on automatic pilot, often in a very advantageous way. This creates a tendency to stick to routines, and the only way of breaking these is to confront the brain with new information.

All the experiences in your life- from single conversations to your broader culture- shape the microscopic details of your brain. Neurally speaking, who you are depends on where you've been. Your brain is a relentless shape-shifter, constantly rewriting its own circuitry- and because your experiences are unique, so are the vast detailed patterns in your neural networks. Because they continue to change your whole life, your identity is a moving target; it never reaches an endpoint.

The detection of a person as safe or dangerous triggers neurobiologically determined pro-social or defensive behaviors. Even though we may not always be aware of danger on a cognitive level, on a neurophysiological level, our body has already started a sequence of neural processes that would facilitate adaptive defense behaviors such as fight, flight or freeze. 

In ways that certain of us are uncomfortable about, SNOOTs’ attitudes about contemporary usage resemble religious/political conservatives’ attitudes about contemporary culture. We combine a missionary zeal and a near-neural faith in our beliefs’ importance with a curmudgeonly hell-in-a-handbasket despair at the way English is routinely manhandled and corrupted by supposedly educated people. The Evil is all around us: boners and clunkers and solecistic howlers and bursts of voguish linguistic methane that make any SNOOT’s cheek twitch and forehead darken. A fellow SNOOT I know likes to say that listening to most people’s English feels like watching somebody use a Stradivarius to pound nails: We are the Few, the Proud, the Appalled at Everyone Else.

He wondered what made a person a person. Was it something mystical like a soul? Something scientific like neural connections in the brain? Or something simpler like the ability to make someone miss you ten years after you'd died?

Looking back on his life, he sees himself spread out on the earth like a giant covered in tiny threads that have held him down. Tiny threads of petty cares and small concerns, and fears he took seriously at the time. Debts, timetables, the need for money, the longing for comfort; the earworm of sex, repeating itself over and over like a neural feedback loop. He’s been the puppet of his own constricted desires.

The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life. This project is ambitious but technically feasible. It is also instrumentally rational and ethically mandatory. The metabolic pathways of pain and malaise evolved only because they once served the fitness of our genes. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last aversive experience will be a precisely dateable event.

Is it very different at home, or on the street, or waiting at the gate to board a flight? I maintain myself on the puppet drug of personal technology. Every touch of a button brings the neural rush of finding something I never knew and never needed to know until it appears at my anxious fingertips, where it remains for a shaky second before disappearing forever.

In the economy of the body, the limbic highway takes precedence over the neural pathways. We were designed and built to feel, and there is no thought, no state of mind, that is not also a feeling state. Nobody can feel too much, though many of us work very hard at feeling too little. Feeling is frightening. Well, I find it so.

Forthrightness is the brain’s default response: our neural wiring transmits our every minor mood onto the muscles of our face, making our feelings instantly visible. The display of emotion is automatic and unconscious, and so its suppression demands conscious effort. Being devious about what we feel—trying to hide our fear or anger—demands active effort and rarely succeeds perfectly.22

Internalizing problem-solving techniques enhances the neural activity that allows you to more easily hear the whispers of your growing intuition. When you know—really know—how to solve a problem just by looking at it, you’ve created a commanding chunk that sweeps like a song through your mind.

Medusa's lips split with that challenging smile, and for a second he recognized her somehow, he knew her on some primal level, the same way he'd recognized he behind the face of Brunhilde, the helmet of Achilles, or in hat ship maneuvering in space ,and then she flickered away. The simulation darkened around him. Tom pulled out his neural wire, Medusa's dangerous smile lingering in his brain.

Synapses in motion tend to stay in motion. Synapses at rest tend to stay at rest.

Unrelenting criticism, especially when it is ground in with parental rage and scorn, is so injurious that it changes the structure of the child’s brain. Repeated messages of disdain are internalized and adopted by the child, who eventually repeats them over and over to himself. Incessant repetitions result in the construction of thick neural pathways of self-hate and self-disgust. Over time a self-hate response attaches to more and more of the child’s thoughts, feelings and behaviors. Eventually, any inclination toward authentic or vulnerable self-expression activates internal neural networks of self-loathing. The child is forced to exist in a crippling state of self-attack, which eventually becomes the equivalent of full-fledged self-abandonment. The ability to support himself or take his own side in any way is decimated. With ongoing parental reinforcement, these neural pathways expand into a large complex network that becomes an Inner Critic that dominates mental activity. The inner critic’s negative perspective creates many programs of self-rejecting perfectionism. At the same time, it obsesses about danger and catastrophizes incessantly.

Every form of human conflict may be reduced to precisely the same pattern of mental events. We are all totalitarian despots over our own thoughts, bound to keep our minds in complete control. Control requires security. Security demands war. All war is the macrocosmic residue of neural synapses struggling to maintain their rhythm.

Our greatest strength is the exact opposite of narrow specialization. It is the ability to integrate broadly. According to Gary Marcus, a psychology and neural science professor who sold his machine learning company to Uber, “In narrow enough worlds, humans may not have much to contribute much longer. In more open-ended games, I think they certainly will. Not just games, in open ended real-world problems we’re still crushing the machines.

I was told that the disorder was not really in my eyes, but in my central nervous system. I might or might not experience symptoms of neural damage all my life. These symptoms, which might or might not appear, might or might not involve my eyes. They might or might not involve my arms or legs, they might or might not be disabling. Their effects might be lessened by cortisone injections, or they might not. It could not be predicted. The condition had a name, the kind of name usually associated with telethons, but the name meant nothing and the neurologist did not like to use it. The name was multiple sclerosis, but the name had no meaning. This was, the neurologist said, an exclusionary diagnosis, and meant nothing. I had, at this time, a sharp apprehension not of what it was like to be old but of what it was like to open the door to the stranger and find that the stranger did indeed have the knife. In a few lines of dialogue in a neurologist’s office in Beverly Hills, the improbable had become the probable, the norm: things which happened only to other people could in fact happen to me. I could be struck by lightning, could dare to eat a peach and be poisoned by the cyanide in the stone. The startling fact was this: my body was offering a precise physiological equivalent to what had been going on in my mind.

When the sunlight hit the trees, all the beauty and wonder come together. Soul unfolds its petals. Flowering and fruiting of plants starts. The birds song light up the spinal column and harmonize the hippocampal functioning.

We get smarter and more creative as we age, research shows. Our brain's anatomy, neural networks, and cognitive abilities can actually improve with age and increased life experiences. Contrary to the mythology of Silicon Valley, older employees may be even more productive, innovative, and collaborative than younger ones... Most people, in fact, have multiple cognitive peaks throughout their lives.

Because of the speed of light. The known universe is about sixteen billion light-years across, and it’s still expanding. But the speed of light is only three hundred thousand kilometers per second, a snail’s pace. This means that light can never go from one end of the universe to the other. Since nothing can move faster than the speed of light, it follows that no information and motive force can go from one end of the universe to the other. If the universe were a person, his neural signals couldn’t cover his entire body; his brain would not know of the existence of his limbs, and his limbs would not know of the existence of the brain. Isn’t that paraplegia? The image in my mind is even worse: The universe is but a corpse puffing up.” “Interesting, Dr. Guan, very interesting!” “Other than the speed of light, three hundred thousand kilometers per second, there’s another three-based symptom.” “What do you mean?” “The three dimensions. In string theory, excepting time, the universe has ten dimensions. But only three are accessible at the macroscopic scale, and those three form our world. All the others are folded up in the quantum realm.

The act of reading together secures people to one another, creating order and connection, as if we were quilt squares tacked together with threads made of stories. That's not just another metaphor, as a team of neuroscientists at Princeton has discovered. Even as reader and listener are enjoying their bouquet of neurochemicals ... their brain activity is synchronizing, creating literal order and connection in a process known as neural coupling.

My generation is on the way out, and each death I have felt as an abruption, a tearing away of part of myself. There will be no one like us when we are gone, but then there is no one like anyone else, ever. When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate — the genetic and neural fate — of every human being to be a unique individual, to find his own path, to live his own life, to die his own death.

Describing good relatedness to someone, no matter how precisely or how often, does not inscribe it into the neural networks that inspire love. Self-help books are like car repair manuals: you can read them all day, but doing so doesn't fix a thing. Working on a car means rolling up your sleeves and getting under the hood, and you have to be willing to get dirt on your hands and grease beneath your fingernails. Overhauling emotional knowledge is no spectator sport; it demands the messy experience of yanking and tinkering that comes from a limbic bond. If someone's relationship today bear a troubled imprint, they do so because an influential relationship left its mark on a child's mind. When a limbic connection has established a neural pattern, it takes a limbic connection to revise it.

He had found a Nutri-Matic machine which had provided him with a plastic cup filled with a liquid that was almost, but not quite, entirely unlike tea. The way it functioned was very interesting. When the Drink button was pressed it made an instant but highly detailed examination of the subject’s taste buds, a spectroscopic analysis of the subject’s metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject’s brain to see what was likely to go down well. However, no one knew quite why it did this because it invariable delivered a cupful of liquid that was almost, but not quite, entirely unlike tea. The Nutri-Matic was designed and manufactured by the Sirius Cybernetics Corporation whose complaint department now covers all the major landmasses of the first three planets in the Sirius Tau Star system.

We focus on other people’s faults. There is a saying that the world is divided into people who think they are right. The more inadequate we feel, the more uncomfortable it is to admit our faults. Blaming others temporarily relieves us from the weight of failure. The painful truth is that all of these strategies simply reinforce the very insecurities that sustain the trance of unworthiness. The more we anxiously tell ourselves stories about how we might fail or what is wrong with us or with others, the more we deepen the grooves—the neural pathways—that generate feelings of deficiency. Every time we hide a defeat we reinforce the fear that we are insufficient. When we strive to impress or outdo others, we strengthen the underlying belief that we are not good enough as we are. This doesn’t mean that we can’t compete in a healthy way, put wholehearted effort into work or acknowledge and take pleasure in our own competence. But when our efforts are driven by the fear that we are flawed, we deepen the trance of unworthiness.

As the blood poured from his tattered heart into the open air and his brain suffocated, all those incomplete thoughts of Wittgenstein decayed with the dying neurons. Neural connections in the gray matter storing memories and ideas in their ordered configurations fired across the gaps, last gaps of mental life. Thoughts on Truth and Will were erased as flesh sloshed soft and limp against alabaster, no more than rotting human fruit.

If music serves to convey feelings through the interaction of physical gestures and sound, the musician needs his brain state to match the emotional state he is trying to express. Although the studies haven't been performed yet, I'm willing to bet that when B.B. King is playing the blues and when he is feeling the blues, the neural signatures are very similar. (Of course there will be differences, too, and part of the scientific hurdle will be subtracting out the processes involved in issuing motor commands and listening to music, versus just sitting on a chair, head in hands, and feeling down.) And as listeners, there is every reason to believe that some of our brain states will match those of the musicians we are listening to.

The systems we will be exploring in order are: ● Breeding Targets: Arousal patterns tied to systems meant to get our ancestors to have sex with things that might bear offspring (e.g., arousal from things like penises, the female form, etc.). ● Inverse Systems: Arousal patterns that arise from a neural mix-up, causing something that disgusts the majority of the population to arouse a small portion of it (e.g., arousal from things like being farted on, dead bodies, having insects poured on one’s face, etc.). ● Emotional States and Concepts / Dominance and Submission: Arousal patterns that stem from either emotional concepts (such as betrayal, transformation, being eaten, etc.) or dominance and submission pathways. ● Emotional Connections to People: While emotional connections do not cause arousal in and of themselves, they do lower the threshold for arousal (i.e., you may become more aroused by a moderately attractive person you love than a very attractive stranger). ● Trope Attraction: Arousal patterns that are enhanced through a target’s adherence to a specific trope (a nurse, a goth person, a cheerleader, etc.). ● Novelty: Arousal patterns tied to the novelty of a particular stimulus. ● Pain and Asphyxiation: Arousal patterns associated with or enhanced by pain and oxygen deprivation. ● Basic Instincts: Remnants of our pre-cognitive mating instincts running off of a “deeper” autopilot-like neurological system (dry humping, etc.) that compel mating behavior without necessarily generating a traditional feeling of arousal. ● Physical Stimuli: Arousal patterns derived from physical interaction (kissing, touching an erogenous zone, etc.). ● Conditioned Responses: Arousal patterns resulting from conditioning (arousal from shoes, doorknobs, etc.).

Because memory…is everything. Physically speaking, a memory is nothing but a specific combination of neurons firing together—a symphony of neural activity. But in actuality, it’s the filter between us and reality. You think you’re tasting this wine, hearing the words I’m saying, in the present, but there’s no such thing. The neural impulses from your taste buds and your ears get transmitted to your brain, which processes them and dumps them into working memory—so by the time you know you’re experiencing something, it’s already in the past. Already a memory.” Helena leans forward, snaps her fingers. “Just what your brain does to interpret a simple stimulus like that is incredible. The visual and auditory information arrive at your eyes and ears at different speeds, and then are processed by your brain at different speeds. Your brain waits for the slowest bit of stimulus to be processed, then reorders the neural inputs correctly, and lets you experience them together, as a simultaneous event—about half a second after what actually happened. We think we’re perceiving the world directly and immediately, but everything we experience is this carefully edited, tape-delayed reconstruction.

Individuality is deeply imbued in us from the very start, at the neuronal level. Even at a motor level, researchers have shown, an infant does not follow a set pattern of learning to walk or how to reach for something. Each baby experiments with different ways of reaching for objects and over the course of several months discovers or selects his own motor solutions. When we try to envisage the neural basis of such individual learning, we might imagine a "population" of movements (and their neural correlates) being strengthened or pruned away by experience. Similar considerations arise with regard to recover and rehabilitation after strokes and other injuries. There are no rules; there is no prescribed path of recovery; every patient must discover or create his own motor and perceptual patterns, his own solutions to the challenges that face him; and it is the function of a sensitive therapist to help him in this. And in its broadest sense, neural Darwinism implies that we are destined, whether we wish it or not, to a life of particularity and self-development, to make our own individual paths through life.

The current technological and scientific revolution implies not that authentic individuals and authentic realities can be manipulated by algorithms and TV cameras, but rather that authenticity is a myth. People are afraid of being trapped inside a box, but they don’t realise that they are already trapped inside a box – their brain – which is locked within a bigger box – human society with its myriad fictions. When you escape the matrix the only thing you discover is a bigger matrix. When the peasants and workers revolted against the tsar in 1917, they ended up with Stalin; and when you begin to explore the manifold ways the world manipulates you, in the end you realise that your core identity is a complex illusion created by neural networks.

This sense of the brain’s remarkable plasticity, its capacity for the most striking adaptations, not least in the special (and often desperate) circumstances of neural or sensory mishap, has come to dominate my own perception of my patients and their lives. So much so, indeed, that I am sometimes moved to wonder whether it may not be necessary to redefine the very concepts of “health” and “disease,” to see these in terms of the ability of the organism to create a new organization and order, one that fits its special, altered disposition and needs, rather than in the terms of a rigidly defined “norm.

The neural basis for the self, as I see it, resides with the continuous reactivation of at least two sets of representations. One set concerns representations of key events in an individual's autobiography, on the basis of which a notion of identity can be reconstructed repeatedly, by partial activation in topologically organized sensory maps. ... In brief, the endless reactivation of updated images about our identity (a combination of memories of the past and of the planned future) constitutes a sizable part of the state of self as I understand it. The second set of representations underlying the neural self consists of the primordial representations of an individual's body ... Of necessity, this encompasses background body states and emotional states. The collective representation of the body constitute the basis for a "concept" of self, much as a collection of representations of shape, size, color, texture, and taste can constitute the basis for the concept of orange.

Western culture prefers us not to believe we're defined or limited. It wants us to buy the fiction that the self is open, free, nothing but pure, bright possibility; that we're all born with the same suite of potential abilities, as neural 'blank slates', as if all human brains come off the production line at Foxconn. This seduces us into accepting the cultural lie that says we can do anything we set our minds to, that we can be whoever we want to be. This false idea is of immense value to our neoliberal economy. The game it compels us to play can best be justified morally if all the contestants start out with an equal shot at winning. Moreover, if we believe we're all the same, this legitimizes calls for deregulated corporation and smaller government: it means that men and women who lose simply didn't want it badly enough, that they just didn't believe - in which case, why should anyone else catch their fall?

It’s possible that the reason I've never experienced a ghostly presence is that my temporal lobes aren't wired for it. It could well be that the main difference between skeptics (Susan Blackmore notwithstanding) and believers is the neural structure they were born with. But the question still remains: Are these people whose EMF-influenced brains alert them to “presences” picking up something real that the rest of us can’t pick up, or are they hallucinating? Here again, we must end with the Big Shrug, a statue of which is being erected on the lawn outside my office.

Is a mind a complicated kind of abstract pattern that develops in an underlying physical substrate, such as a vast network of nerve cells? If so, could something else be substituted for the nerve cells – something such as ants, giving rise to an ant colony that thinks as a whole and has an identity – that is to say, a self? Or could something else be substituted for the tiny nerve cells, such as millions of small computational units made of arrays of transistors, giving rise to an artificial neural network with a conscious mind? Or could software simulating such richly interconnected computational units be substituted, giving rise to a conventional computer (necessarily a far faster and more capacious one than we have ever seen) endowed with a mind and a soul and free will?

Self-parenting exercises taught me to slowly rebuild healthy self-talk. But it must be said: Even though I know reparenting had helped dozens of my friends and acquaintances, almost everyone has told me it’s exhausting. Reparenting takes time, and concentration, and calmness. It takes an intellectual and physical effort to shove aside the comfortably worn neural pathways and go in a different direction. And even though that effort comes with joyous rewards, sometimes it also comes with sadness. Because expressing the kindness to yourself that you deserve often reminds you of the kindness you didn’t get.

Dreaming may simply be a by-product of this nightly cerebral housecleaning. As the brain clears wastes and consolidates memories, neural circuits fire randomly, briefly throwing up fragmentary images, a bit like someone jumping between television channels when looking for something to watch. Confronted with this incoherent flow of memories, anxieties, fantasies, suppressed emotions, and the like, the brain possibly tries to make a sensible narrative out of it all, or possibly, because it is itself resting, doesn’t try at all, and just lets the incoherent pulses flow past. That may explain why we generally don’t remember dreams much despite their intensity—because they are not actually meaningful or important.

After three of four years of schooling, the nucleus basalis, which forms sharp memories in the brain, falls into disuse and decays. This is the part of the brain that makes learning so effortless for small children, and it is always activated in undomesticated humans. But neuroplasticity research has shown that damage to the nucleus basalis can be reversed by reintroducing activities involving highly focused attention, which results in massive increases in production of acetylcholine and dopamine. Using new skills under conditions of intense focus rewires billions of neural connections and reactivates the nucleus basalis. Loss of function in this part of the brain is not a natural stage of development--we are supposed to retain and even increase it throughout our lives. Until very recently in human history, we did.

What science offers for explaining the feelings we experience when believing in God or falling in love is complementary, not conflicting; additive, not detractive. I find it deeply interesting to know that when I fall in love with someone my initial lustful feelings are enhanced by dopamine, a neurohormone produced by the hypothalamus that triggers the release of testosterone, the hormone that drives sexual desire, and that my deeper feelings of attachment are reinforced by oxytocin, a hormone synthesized in the hypothalamus and secreted into the blood by the pituitary. Further, it is instructive to know that such hormone-induced neural pathways are exclusive to monogamous pair-bonded species as an evolutionary adaptation for the long-term care of helpless infants. We fall in love because our children need us! Does this in any way lessen the qualitative experience of falling in love and doting on one’s children? Of course not, any more than unweaving a rainbow into its constituent parts reduces the aesthetic appreciation of the rainbow.

Nature likes to overinsure itself. Layers of redundancy are the central risk management property of natural systems. We humans have two kidneys (this may even include accountants), extra spare parts, and extra capacity in many, many things (say, lungs, neural system, arterial apparatus), while human design tends to be spare and inversely redundant, so to speak—we have a historical track record of engaging in debt, which is the opposite of redundancy (fifty thousand in extra cash in the bank or, better, under the mattress, is redundancy; owing the bank an equivalent amount, that is, debt, is the opposite of redundancy). Redundancy is ambiguous because it seems like a waste if nothing unusual happens. Except that something unusual happens—usually.

Scientists are cautiously beginning to question the view that the brain is the sole and absolute ruler over the body. The gut not only possesses an unimaginable number of nerves, those nerves are also unimaginably different from those of the rest of the body. The gut commands an entire fleet of signaling substances, nerve-insulation materials, and ways of connecting. There is only one other organ in the body that can compete with the gut for diversity—the brain. The gut’s network of nerves is called the “gut brain” because it is just as large and chemically complex as the gray matter in our heads. Were the gut solely responsible for transporting food and producing the occasional burp, such a sophisticated nervous system would be an odd waste of energy. Nobody would create such a neural network just to enable us to break wind. There must be more to it than that.

The role of dominance and submission in human sexuality cannot be overstated. Our survey suggests that the majority (over 50%) of humans are very aroused by either acting out or witnessing dominance or submission. But it gets crazier than that: While 45% of women taking our survey said they found the naked male form to be very arousing and 48% said they found the sight of a penis to very arousing, a heftier 53% said they found their partner acting dominant in a sexual context to be very arousing. Dominance is literally more likely to be very arousing to the average female than naked men or penises. To say: “Dominance and submission are tied to human arousal patterns” is more of an understatement than saying: “Penises are tied to human arousal patterns.” We have a delectable theory about what is going on here: If you look at all the emotional states that frequently get tied to arousal pathways, the vast majority of them seem to be proxies for behaviors that would have been associated with our pre-human ancestors’ and early humans’ dominance and submission displays. For example, things like humiliation, being taken advantage of, chains, being used, being useful, being constrained, a lack of freedom, being prey, and a lack of free will may all have been concepts and emotions important in early human submission displays. We posit that most of the time when a human is turned on by a strange emotional concept—being bound for instance—their brain is just using that concept as a proxy for a pre-human submission display and lighting up the neural pathways associated with it, creating a situation in which it looks like a large number of random emotional states are turning humans on, when in reality they all boil down to just a fuzzy outline of dominance and submission. Heck, speaking of binding as a submission display, there were similar ritualized submission displays in the early middle ages, in which a vassal would present their hands clasped in front of their lord and allow the lord to hold their clasped hands in a way that rendered them unable to unclasp them (this submission display to one’s lord is where the symbolism of the Christian kneeling and hands together during prayer ritual comes from). We suspect the concept of binding and defenselessness have played important roles in human submission displays well into pre-history. Should all this be the case, why on earth have our brains been hardwired to bind (hehe) our recognition of dominance and submission displays to our sexual arousal systems?!?

When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate—the genetic and neural fate—of every human being to be a unique individual, to find his own path, to live his own life, to die his own death. I cannot pretend I am without fear. But my predominant feeling is one of gratitude. I have loved and been loved; I have been given much and I have given something in return; I have read and traveled and thought and written. I have had an intercourse with the world, the special intercourse of writers and readers. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure.

Jazz presumes that it would be nice if the four of us--simpatico dudes that we are--while playing this complicated song together, might somehow be free and autonomous as well. Tragically, this never quite works out. At best, we can only be free one or two at a time--while the other dudes hold onto the wire. Which is not to say that no one has tried to dispense with wires. Many have, and sometimes it works--but it doesn't feel like jazz when it does. The music simply drifts away into the stratosphere of formal dialectic, beyond our social concerns. Rock-and-roll, on the other hand, presumes that the four of us--as damaged and anti-social as we are--might possibly get it to-fucking-gether, man, and play this simple song. And play it right, okay? Just this once, in tune and on the beat. But we can't. The song's too simple, and we're too complicated and too excited. We try like hell, but the guitars distort, the intonation bends, and the beat just moves, imperceptibly, against our formal expectations, whetehr we want it to or not. Just because we're breathing, man. Thus, in the process of trying to play this very simple song together, we create this hurricane of noise, this infinitely complicated, fractal filigree of delicate distinctions. And you can thank the wanking eighties, if you wish, and digital sequencers, too, for proving to everyone that technologically "perfect" rock--like "free" jazz--sucks rockets. Because order sucks. I mean, look at the Stones. Keith Richards is always on top of the beat, and Bill Wyman, until he quit, was always behind it, because Richards is leading the band and Charlie Watts is listening to him and Wyman is listening to Watts. So the beat is sliding on those tiny neural lapses, not so you can tell, of course, but so you can feel it in your stomach. And the intonation is wavering, too, with the pulse in the finger on the amplified string. This is the delicacy of rock-and-roll, the bodily rhetoric of tiny increments, necessary imperfections, and contingent community. And it has its virtues, because jazz only works if we're trying to be free and are, in fact, together. Rock-and-roll works because we're all a bunch of flakes. That's something you can depend on, and a good thing too, because in the twentieth century, that's all there is: jazz and rock-and-roll. The rest is term papers and advertising.

The more a sufferer concentrates on his symptoms, the deeper those symptoms are etched into his neural circuits. In the worst cases, the mind essentially trains itself to be sick. Many addictions, too, are reinforced by the strengthening of plastic pathways to the brain. Even very small doses of addictive drugs can dramatically alter the flow of neurotransmitters in a person’s synapses, resulting in long-lasting alterations in brain circuitry and function. In some cases, the buildup of certain kinds of neurotransmitters, such as dopamine, a pleasure-producing cousin to adrenaline, seems to actually trigger the turning on or off particular genes, bringing even stronger cravings for the drug. The vital path turns deadly.

In the statistical gargon used in psychology, p refers to the probability that the difference you see between two groups (of introverts and extroverts, say, or males and females) could have occurred by chance. As a general rule, psychologists report a difference between two groups as 'significant' if the probability that it could have occurred by chance is 1 in 20, or less. The possibility of getting significant results by chance is a problem in any area of research, but it's particularly acute for sex differences research. Supppose, for example, you're a neuroscientist interested in what parts of the brain are involved in mind reading. You get fifteen participants into a scanner and ask them to guess the emotion of people in photographs. Since you have both males and females in your group, you rin a quick check to ensure that the two groups' brains respond in the same way. They do. What do you do next? Most likely, you publish your results without mentioning gender at all in your report (except to note the number of male and female participants). What you don't do is publish your findings with the title "No Sex Differences in Neural Circuitry Involved in Understanding Others' Minds." This is perfectly reasonable. After all, you weren't looking for gender difference and there were only small numbers of each sex in your study. But remember that even if males and females, overall, respond the same way on a task, five percent of studies investigating this question will throw up a "significant" difference between the sexes by chance. As Hines has explained, sex is "easily assessed, routinely evaluated, and not always reported. Because it is more interesting to find a difference than to find no difference, the 19 failures to observe a difference between men and women go unreported, whereas the 1 in 20 finding of a difference is likely to be published." This contributes to the so-called file-drawer phenomenon, whereby studies that do find sex differences get published, but those that don't languish unpublished and unseen in a researcher's file drawer.

Uncouth, clannish, lumbering about the confines of Space and Time with a puzzled expression on his face and a handful of things scavenged on the way from gutters, interglacial littorals, sacked settlements and broken relationships, the Earth-human has no use for thinking except in the service of acquisition. He stands at every gate with one hand held out and the other behind his back, inventing reasons why he should be let in. From the first bunch of bananas, his every sluggish fit or dull fleabite of mental activity has prompted more, more; and his time has been spent for thousands of years in the construction and sophistication of systems of ideas that will enable him to excuse, rationalize, and moralize the grasping hand. His dreams, those priceless comic visions he has of himself as a being with concerns beyond the material, are no more than furtive cannibals stumbling round in an uncomfortable murk of emotion, trying to eat each other. Politics, religion, ideology — desperate, edgy attempts to shift the onus of responsibility for his own actions: abdications. His hands have the largest neural representation in the somesthetic cortex, his head the smallest; but he's always trying to hide the one behind the other.

Stress and glucocorticoids have inverted-U effects here as well. Moderate, transient stress (or exposure to the equivalent glucocorticoid levels) increases spine number in the hippocampus; sustained stress or glucocor-ticoid exposure does the opposite.7 Moreover, major depression or anxiety—two disorders associated with elevated glucocorticoid levels—can reduce hippocampal dendrite and spine number. This arises from decreased levels of that key growth factor mentioned earlier this chapter, BDNF. Sustained stress and glucocorticoids also cause dendritic retraction and synapse loss, lower levels of NCAM (a “neural cell adhesion molecule” that stabilizes synapses), and less glutamate release in the frontal cortex.

After he had sailed around the Mediterranean in 1869, Mark Twain said that travel was “fatal to prejudice, bigotry, and narrow-mindedness.” Neuroscientists have been trying for years to pin down what it is about travel that alters us, how it effects mental change. Neural pathways become ingrained, automatic, if they operate only by habit. They are highly attuned to alterations, to novelty. New sights, sounds, languages, tastes, smells stimulate different synapses in the brain, different message routes, different webs of connection, increasing our neuroplasticity. Our brains have evolved to notice differences in our environment: it’s how we’re alerted to predators, to potential danger. To be sensitive to change, then, is to ensure survival.

A synthesis—an abstraction, chunk, or gist idea—is a neural pattern. Good chunks form neural patterns that resonate, not only within the subject we’re working in, but with other subjects and areas of our lives. The abstraction helps you transfer ideas from one area to another. That’s why great art, poetry, music, and literature can be so compelling. When we grasp the chunk, it takes on a new life in our own minds—we form ideas that enhance and enlighten the neural patterns we already possess, allowing us to more readily see and develop other related patterns. Once we have created a chunk as a neural pattern, we can more easily pass that chunked pattern to others, as Cajal and other great artists, poets, scientists, and writers have done for millennia, Once other people grasp that chunk, not only can they use it, but also they can more easily create similar chunks that apply to other areas in their lives—an important part of the creative process.

It is difficult to describe how it feels to gaze at living human beings whom you’ve seen perform in hard-core porn. To shake the hand of a man whose precise erectile size, angle, and vasculature are known to you. That strange I-think-we’ve-met-before sensation one feels upon seeing any celebrity in the flesh is here both intensified and twisted. It feels intensely twisted to see reigning industry queen Jenna Jameson chilling out at the Vivid booth in Jordaches and a latex bustier and to know already that she has a tattoo of a sundered valentine with the tagline HEART BREAKER on her right buttock and a tiny hairless mole just left of her anus. To watch Peter North try to get a cigar lit and to have that sight backlit by memories of his artilleryesque ejaculations.13 To have seen these strangers’ faces in orgasm—that most unguarded and purely neural of expressions, the one so vulnerable that for centuries you basically had to marry a person to get to see it.

mental activity such as directing attention, actually shape the structure of the brain?” As we’ve seen, experience means neural firing. When neurons fire together, the genes in their nuclei—their master control centers—become activated and “express” themselves. Gene expression means that certain proteins are produced. These proteins then enable the synaptic linkages to be constructed anew or to be strengthened. Experience also stimulates the production of myelin, the fatty sheath around axons, resulting in as much as a hundredfold increase in the speed of conduction down the neuron’s length. And as we now know, experience can also stimulate neural stem cells to differentiate into wholly new neurons in the brain. This neurogenesis, along with synapse formation and myelin growth, can take place in response to experience throughout our lives. As discussed before, the capacity of the brain to change is called neuroplasticity We are now discovering how the careful focus of attention amplifies neuroplasticity by stimulating the release of neurochemicals that enhance the structural growth of synaptic linkages among the activated neurons.

This new science of performance argues that you get better at a skill as you develop more myelin around the relevant neurons, allowing the corresponding circuit to fire more effortlessly and effectively. To be great at something is to be well myelinated. This understanding is important because it provides a neurological foundation for why deliberate practice works. By focusing intensely on a specific skill, you’re forcing the specific relevant circuit to fire, again and again, in isolation. This repetitive use of a specific circuit triggers cells called oligodendrocytes to begin wrapping layers of myelin around the neurons in the circuits—effectively cementing the skill. The reason, therefore, why it’s important to focus intensely on the task at hand while avoiding distraction is because this is the only way to isolate the relevant neural circuit enough to trigger useful myelination. By contrast, if you’re trying to learn a complex new skill (say, SQL database management) in a state of low concentration (perhaps you also have your Facebook feed open), you’re firing too many circuits simultaneously and haphazardly to isolate the group of neurons you actually want to strengthen. In

Pattern recognition is so basic that the brain's pattern detection modules and its reward circuitry became inextricably linked. Whenever we successfully detect a pattern-or think we detect a pattern-the neurotransmitters responsible for sensations of pleasure squirt through our brains. If a pattern has repeated often enough and successfully enough in the past, the neurotransmitter release occurs in response to the mere presence of suggestive cues, long before the expected outcome of that pattern actually occurs. Like the study participants who reported seeing regular sequences in random stimuli, we will use alomst any pretext to get our pattern recognition kicks. Pattern recognition is the most primitive form of analogical reasoning, part of the neural circuitry for metaphor. Monkeys, rodents, and birds recognize patterns, too. What distinguishes humans from other species, though, is that we have elevated pattern recognition to an art. "To understand," the philosopher Isaiah Berlin observed, "is to perceive patterns." Metaphor, however, is not the mere detection of patterns; it is the creation of patterns, too. When Robert Frost wrote, "A bank is a place where they lend you an umbrella in fair weather and ask for it back when it begins to rain" his brain created a pattern connecting umbrellas to banks, a pattern retraced every time someone else reads this sentence. Frost believed passionately that an understanding of metaphor was essential not just to survival in university literature courses but also to survival in daily life.