Motor Neurone Disease Quotes

Three years ago I was diagnosed with Motor Neurone Disease. The

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

After the war, in the early fifties, when the great break-throughs in science followed one after the other so rapidly, there wasn't time to take stock, to ask the sensible questions. Suddenly there were all these new possibilities laid before us, all these ways to cure so many previously incurable conditions. This was what the world noticed the most, wanted the most. And for a long time, people preferred to believe these organs appeared from nowhere, or at most that they grew in a kind of vacuum. Yes, there were arguments. But by the time people became concerned about . . . about students, by the time they came to consider just how you were reared, whether you should have been brought into existence at all, well by then it was too late. There was no way to reverse the process. How can you ask a world that has come to regard cancer as curable, how can you ask such a world to put away that cure, to go back to the dark days? There was no going back. However uncomfortable people were about your existence, their overwhelming concern was that their own children, their spouses, their parents, their friends, did not die from cancer, motor neurone disease. So for a long time you were kept in the shadows, and people did their best not to think about you. And if they did, they tried to convince themselves you weren't really like us. That you were less than human, so it didn't matter.

From your perspective today, Kathy, your bemusement is perfectly reasonable. But you must try and see it historically. After the war, in the early fifties, when the great breakthroughs in science followed one after another so rapidly, there wasn't time to take stock, to ask the sensible questions. Suddenly there were all these new possibilities laid before us, all these ways to cure so many previously incurable conditions. This was what the world noticed the most, wanted the most...By the time people became concerned about students, by the time they came to consider just how you were reared, whether you should have been brought into existence at all, well, by then it was too late...How can you ask a world that has come to regard cancer as curable, how can you ask such a world to put away that cure, to go back to the dark days? There was no going back. However uncomfortable people were about your existence, their overwhelming concern was that their own children, their spouses, their parents, their friends, did not die from cancer, motor neurone disease, heart disease. For a long time you were kept in the shadow...[and if people think about you], they tried to convince themselves you weren't really like us. That you were less than human, so it didn't matter...Do you see what we were up against? We were virtually attempting to square the circle. Here was the world, requiring students to donate. While that remained the case, there would always be a barrier against seeing you as properly human.

It is within this network of intermediary neurons, arranged end-to-end and side-by-side between our sensory nerve endings and our motor units, that all of our tone levels, reflexes, gestures, habits, tendencies, feelings, attitudes, postures, styles have their genesis. It is called the internuncial net, and it has come into its fullest flower in the human being. [Internuncios were official messengers for the Pope, taking information and bringing back responses from the various courts of Europe.) This net composes roughly ninety percent of our nervous systems, including the entire spinal cord and the brain. It is nothing less than the total activity of this internuncial net which influences the responses of the motor units. Let us recall our stiff old man who was anaesthetized for surgery. The anaesthesia had no direct effect on either sensory endings or motor units; rather, it interrupted the normal flow of signals in the internuncial network in the brain. The result was flaccid, unresponsive muscles, and a blanking out of all sensation produced by the scalpel and the probe. It is only by influencing the flow of impulses through the vast internuncial net that we can have any effect upon tone, habit, and behavior. The conditions which direct that flow into specific patterns have been evolved through the handling of particular qualities and amounts of sensory experience and the repetitions of specific appropriate motor responses. One of the readiest means we have of actually influencing—rather than just temporarily interrupting—the conditions within the net is the introduction of more and more positive sensory experience, which elicits new kinds of motor responses, and can thus form the basis for the development of new habits, new conditions, new patterns of neural flow. The complexities of the internuncial net are forbidding. The suggestion that bodywork might in some way make significant and lasting changes in its function may sound like the ravings of a necromancer turned amateur neurosurgeon. We know so very little, and would presume to do so much. And yet we do know that very simple means can produce remarkable and demonstrably repeatable results in this fantastically complicated network. Infants who do not receive adequate physical stimulation die or are dwarfed and deformed. Laboratory rats who are handled on a daily basis develop markedly stronger resistance to fatal diseases, even to the loss of vital organs. Between these two extremes is a wide spectrum of quantity and quality of touching, all of which must certainly affect the health of the organism if touch in the orphanage and in the laboratory can be proven to be so crucial.

Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig’s disease, is a progressive, highly morbid, debilitating neurological disease that attacks the neurons responsible for controlling voluntary muscles. The disease is one of a group of motor neuron diseases in which the etiology is characterized by

Stephen Hawking, the scientist whose incurable motor-neuron disease left him paralyzed and unable to talk at age 21.

This has been used with some success in the treatment of Parkinson’s disease, which results from the loss of neurons that make dopamine.116 Areas responsible for motor control depend on dopamine, and its absence leads to dysregulation of the associated circuits and results in tremors. In gene therapy for Parkinson’s, genes are attached to viruses that are injected into the motor control regions of the basal ganglia and carry the new genes into neurons. The

In Parkinson's disease (PD), the results of dopamine deficiency include increased neuronal activity in the subthalamic nucleus (STN) and globus pallidus internus (GPi), with irregular and bursting neuronal firing patterns. Increased synchrony is found among sensorimotor networks, which may contribute to PD motor signs.

astrocytes, and Myron’s discus thrower was using his neurons. For the astrocyte to be the root of thought, it must be able to process sensory information coming from neurons. It must also be able to communicate to motor neurons to stimulate action. In the peripheral nerves, electrical impulses rapidly fire through sodium and potassium exchange to the muscles to cause contraction, electrical impulses we know as “action potentials.” Action potentials also carry information pertaining to sensory input from the body to the brain.