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patients with initially negative tests will develop positive results if retested six weeks later.) Proof of Lyme disease among these individuals who are negative on the two-tiered approach to testing may be hard to obtain, but occasionally one may get confirmation from other positive tests such as other antibody-based tests (C6 peptide ELISA or an IgG Western blot [even though the ELISA is negative]), a PCR assay for Borrelia DNA, or growth of the organism in culture. Experimental or newer tests (for example, tests of immune complexes or of Borrelia specific proteins) may also prove informative
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