Glucose Quotes

It is mainly the soluble fiber and magnesium that lowered the author's fasting pre-diabetes blood glucose to 90s and 100s without taking medication

What is Insulin? Insulin is a hormone that allows the glucose (also called blood sugar) in your blood to get out of your bloodstream and into your cells for energy for whatever your current activity or inactivity is. If you have more glucose in your bloodstream than your current energy need, the excess is stored in your liver (called glycogen in its storage form). If your liver is full and you still have excess glucose in your bloodstream, the rest is stored as body fat around your butt, thighs, belly—and generally every place you don’t want it to be. 

Most weight-loss books are written by smart, well-intentioned people who read a lot of other weight-loss books and write their book based on their collected 2nd hand knowledge and their personal experience. Glucose Control Eating© is different. It’s based on over 40 years of empirical testing and over 85,000 tests on the impact of foods and drinks on weight. 

People all over the United States are ready to try to take off the unwanted weight they gained. They’re ready to start walking, jogging, riding bikes, taking exercise classes, walking the malls, or just moving more outside. They’re hoping to lose the weight they have gained. But they’ll fail, mostly.

How do you control the amount of insulin your body produces?  You control the amount of glucose you put into your bloodstream. Put in less glucose, your body will produce less insulin, and you will lose weight. Put in more glucose, your body will produce more insulin, and you will gain weight. That brings us to the premise of this book: Control your blood glucose, and you control your weight.    Lower blood glucose, and you will lose weight. This is universal.  How do you lower your blood glucose? The answers are in Glucose Control Eating©.

What Foods Create Blood Glucose? Blood glucose is not created just by sweets—it’s created by all foods. Proteins create glucose, fats create glucose, vegetables create glucose, fruits create glucose, fruit juices create glucose, starchy foods create glucose, and of course, sweets create glucose. So the key to losing weight is to consume less of the foods (including drinks) that create large amounts of glucose and replace them with foods and beverages that create smaller amounts of glucose and go into the bloodstream more slowly.

The Premise of Glucose Control Eating© You control the amount of glucose you put into your bloodstream. Put in less glucose, your body will produce less insulin, and you will lose weight. Put in more glucose, your body will produce more insulin, and you will gain weight. That brings us to the premise of this book.   Control your glucose, and you control your weight.   How do you control your glucose and your weight?    How can you know which foods create lots of glucose and weight gain and which create less glucose and weight loss?   In the book, Glucose Control Eating©, I will not only tell you, but I will also show you, based on over 85,000 blood glucose tests, how much glucose different foods will create in your body.

Your soul: pure glucose edged with hints Of tentative and half-soiled tints

The cream and hot butter mingled and overflowed separating each glucose bead of caviar from its fellows, capping it in white and gold.

The nervous system consumes more glucose than most other parts of the body, and effortful mental activity appears to be especially expensive in the currency of glucose.

Glucose, Sucrose, Fructose, and Lactose—All sugars and sweets Some found in fruits, some in milk, yet others in beets.

Why Is It So Hard to Lose Weight? Body fat is hard to lose because the body automatically burns the easiest energy source first—blood glucose; when blood glucose gets too low, the body then uses the next easiest source of energy—glycogen in the liver—which converts back to glucose and goes into the bloodstream. Then and only then, after the liver is depleted of glycogen, does the body begin to use body fat. That is why body fat is so hard to get rid of. It’s the last source of energy used and is also a very stable molecule that is hard to break down.   You can gain weight easily simply by putting more glucose in your bloodstream than you need for your current activity or inactivity. But it’s harder to lose weight because body fat is the last source of energy your body uses. This is the very reason that you can gain weight quickly, but losing weight takes longer. 

What is the right order? It’s fiber first, protein and fat second, starches and sugars last.

How We Gain and Lose Weight To understand how we gain and lose weight, we need to start with insulin. Medical researchers and internal medicine doctors almost universally agree that the amount of insulin a person produces determines weight gain and weight loss. For example, Gary Taubes, a medical researcher and recipient of multiple awards from the National Association of Science Writers, refers to insulin as “the stop-and-go light of weight gain and loss.”    Produce more insulin—you will gain weight. Produce less insulin— you will lose weight.

Even though I seem not human, a mute shelf of glucose, bottled blood, machinery to swell the lung and pump the heart—even so, do not put out my life. Let me still glow.

The leaves of the world comprise countless billion elaborations of a single, simple machine designed for one job only – a job upon which hinges humankind. Leaves make sugar. Plants are the only things in the universe that can make sugar out of nonliving inorganic matter. All the sugar that you have ever eaten was first made within a leaf. Without a constant supply of glucose to your brain, you will die. Period. Under duress, your liver can make glucose out of protein or fat – but that protein or fat was originally constructed from a plant sugar within some other animal. It’s inescapable: at this very moment, within the synapses of your brain, leaves are fueling thoughts of leaves.

The single most powerful item in our preventive tool kit is exercise, which has a two-pronged impact on Alzheimer’s disease risk: it helps maintain glucose homeostasis, and it improves the health of our vasculature

The key to the proper treatment of type 2 diabetes is to get rid of the excess sugar, not just move it around the body. The problem is both too much glucose and too much insulin.

If you’re going to eat something sweet or starchy, use your muscles afterward. Your muscles will happily uptake excess glucose as it arrives in your blood, and you’ll lessen the glucose spike, reduce the likelihood of weight gain, and avoid an energy slump.

Fructose molecules glycate things 10 times as fast as glucose, generating much more damage. Again, this is another reason why spikes from sugary foods such as cookies (which contain fructose) make us age faster than do spikes from starchy foods such as pasta (which doesn't).

Testosterone also increases confidence and optimism, while decreasing fear and anxiety.5 This explains the “winner” effect in lab animals, where winning a fight increases an animal’s willingness to participate in, and its success in, another such interaction. Part of the increased success probably reflects the fact that winning stimulates testosterone secretion, which increases glucose delivery and metabolism in the animal’s muscles and makes his pheromones smell scarier. Moreover, winning increases the number of testosterone receptors in the bed nucleus of the stria terminalis (the way station through which the amygdala communicates with the rest of the brain), increasing its sensitivity to the hormone. Success in everything from athletics to chess to the stock

Carbohydrates trigger insulin release from the pancreas, causing growth of visceral fat; visceral fat causes insulin resistance and inflammation. High blood sugars, triglycerides, and fatty acids damage the pancreas. After years of overwork, the pancreas succumbs to the thrashing it has taken from glucotoxicity, lipotoxicity, and inflammation, essentially “burning out,” leaving a deficiency of insulin and an increase in blood glucose—diabetes.

The most surprising discovery made by Baumeister’s group shows, as he puts it, that the idea of mental energy is more than a mere metaphor. The nervous system consumes more glucose than most other parts of the body, and effortful mental activity appears to be especially expensive in the currency of glucose.

The more glucose we deliver to our body, the more often glycation happens. Once a molecule is glycated, it's damaged forever - which is why you can't untoast a piece of bread. The long term consequences of glycated molecules range from wrinkles and cataracts to heart disease and Alzheimer's disease. Since browning is aging and aging is browning, slowing down the browning reaction in your body leads to a longer life.

Grab a tall glass of water (some people find that hot water is more soothing), and pour 1 tablespoon of vinegar into it. If you don’t like the taste, start with a teaspoon or even less, and build up to it. Grab a straw, down the drink either less than 20 minutes before, during the course of, or less than 20 minutes after eating the glucose-spiking food.

Sweetness was a sign that a plant was edible (most plants that are poisonous to humans taste bitter). Sweetness is also an indication that the plant is high in glucose, which meant that it would offer us lots of energy.

If the young man ate candy, the wrangler says, that's probably what's kept him alive so long. Glucose is a natural antidote to cyanide poisoning. Based on anecdotal evidence, glucose binds with the cyanide to produce less toxic compounds.

A drink consisting of a tablespoon of vinegar in a tall glass of water, drunk a few minutes before eating something sweet, flattens the ensuing glucose and insulin spikes. With that, cravings are curbed, hunger is tamed, and more fat is burned.

if you eat the items of a meal containing starch, fibre, sugar, protein and fat in a specific order, you reduce your overall glucose spike by 73 per cent, as well as your insulin spike by 48 per cent. This is true for anyone, with or without diabetes. What is the right order? It’s fibre first, protein and fat second, starches and sugars last.

After a stressful event, we often crave comfort food. Our body is calling for more glucose and simple carbohydrates and fat... And in modern life, people tend to have fewer friends and less support, because there's no tribe. Being alone is not good for the brain.

failure of insulin to lower blood glucose is called insulin resistance.

The term ‘mycorrhiza’ is made from the Greek words for ‘fungus’ and ‘root’. It is itself a collaboration or entanglement; and as such a reminder of how language has its own sunken system of roots and hyphae, through which meaning is shared and traded. The relationship between mycorrhizal fungi and the plants they connect is ancient – around 450 million years old – and largely one of mutualism. In the case of the tree–fungi mutualism, the fungi siphon off carbon that has been produced in the form of glucose by the trees during photosynthesis, by means of chlorophyll that the fungi do not possess. In turn, the trees obtain nutrients such as phosphorus and nitrogen that the fungi have acquired from the soil through which they grow, by means of enzymes that the trees lack.

Nothing breaks my heart more than seeing that person who’s struggling to lose weight who thinks that they need to run 20 miles a week. They have no desire to do it, their knees hurt, they hate it, and they’re not losing weight. And I’d like to say, ‘Well, I’ve got great news for you. You don’t ever need to run another step a day in your life, because there’s no value in that.’ “There is value in exercise, though, and I think that the most important type of exercise, especially in terms of bang for your buck, is going to be really high-intensity, heavy strength training. Strength training aids everything from glucose disposal and metabolic health to mitochondrial density and orthopedic stability. That last one might not mean much when you’re a 30-something young buck, but when you’re in your 70s, that’s the difference between a broken hip and a walk in the park.

Your body doesn’t process sugar differently whether it came from a sugar beet, an agave plant, or a mango. As soon as a fruit is denatured and processed and its fiber is extracted, it becomes sugar like any other sugar.

Test Ideal level • fasting blood glucose less than 95 milligrams per deciliter (mg/dL) • fasting insulin below 8 µIU/ml (ideally, below 3) • hemoglobin A1C 4.8 to 5.4 percent • fructosamine 188 to 223 µmol/L • homocysteine 8µmol/L or less • vitamin D 80 ng/mL • C-reactive protein 0.00 to 3.0 mg/L • gluten sensitivity test with Cyrex array 3 test

Eating sugar in excess of what can be immediately burned causes it to be stored in the liver in the form of glucose (glycogen). Since the liver’s capacity is limited, a daily intake of refined sugar soon causes the liver to exceed its ability to store sugar, and the excess glycogen is returned to the blood in the form of fatty acids. These are taken to every part of the body and stored as fat in the most inactive areas: the belly, the buttocks, the breasts, and the thighs.

TRY THIS: Think of your favorite veggie or salad. Prepare it with care, and eat it before every lunch and dinner for a week. Notice your cravings and whether they change.

Strategies that relax and replenish can restore one’s reservoir of willpower and are thus helpful in ADHD. These strategies include: times of relaxation such as meditation, positive emotions, self-talk that is encouraging, time of play, physical exercise, adequate breaks, or even having a snack that increases blood glucose. Motivational strategies such imagery, or physical reminders of or talking about future rewards can also help.

Another, related issue is that longevity itself, and healthspan in particular, doesn’t really fit into the business model of our current healthcare system. There are few insurance reimbursement codes for most of the largely preventive interventions that I believe are necessary to extend lifespan and healthspan. Health insurance companies won’t pay a doctor very much to tell a patient to change the way he eats, or to monitor his blood glucose levels in order to help prevent him from developing type 2 diabetes. Yet insurance will pay for this same patient’s (very expensive) insulin after he has been diagnosed. Similarly, there’s no billing code for putting a patient on a comprehensive exercise program designed to maintain her muscle mass and sense of balance while building her resistance to injury. But if she falls and breaks her hip, then her surgery and physical therapy will be covered. Nearly all the money flows to treatment rather than prevention—and when I say “prevention,” I mean prevention of human suffering.

If I could really love, I would take away these tubes dripping lipids and glucose into your blood. I would liquefy the things you love and flood them through your veins: our sleeping dogs' rhythmic breathing, huge orange trumpets of the amaryllis we thought would never bloom, the crunch of the gravel road coming home. If I could really love, I would climb onto your narrow back and wrap myself around, guarding like a ladybug, or Achilles' mighty shield.

He helped me sit up on my bed and tried to force-feed me glucose dissolved in water and a biscuit he’d grabbed from my roommate’s bedside. But I spat it right out, still thinking about calories and numbers. “That’s enough, Amira. I’m literally trying to feed you water. It’s not going to hurt you!” he screamed.

When blood insulin levels are high, those same fat cells store not only the excess glucose but the fat you ate at your last meal. Moreover, high insulin signals the fat cells to hold on to the fat and not release it for energy. If the pattern of high insulin-generating meals continues, fat cells swell up and you gain weight.

The morphine molecule exerts an analogous brainwashing on humans, pushing them to act contrary to their self-interest in pursuit of the molecule. Addicts betray loved ones, steal, live under freeways in harsh weather, and run similarly horrific risks to use the molecule. It became the poster molecule for an age of excess. No amount of it was ever enough. The molecule created ever-higher tolerance. Plus, it had a way of railing on when the body gathered the courage to throw it out. This wasn’t only during withdrawals. Most drugs are easily reduced to water-soluble glucose in the human body, which then expels them. Alone in nature, the morphine molecule rebelled. It resisted being turned into glucose and it stayed in the body. “We still can’t explain why this happens. It just doesn’t follow the rules. Every other drug in the world—thousands of them—follows this rule. Morphine doesn’t,” Coop said. “It really is almost like someone designed it that way—diabolically so.

Stick recording electrodes into numerous species’ amygdalaefn9 and see when neurons there have action potentials; this turns out to be when the animal is being aggressive.fn10 In a related approach, determine which brain regions consume extra oxygen or glucose, or synthesize certain activity-related proteins, during aggression—the amygdala tops the list.

I'll Stick to weed, Cocaine is just glucose.

Numerous studies confirm that low blood glucose levels lead to impaired attention as well as to difficulties regulating emotions and behavior.

The nervous system consumes more glucose than most other parts of the body,

Even without the immediate rise in blood sugar, fructation—glycation by fructose—is eight- to tenfold worse than glycation by glucose.

Green tea promotes long-term weight loss by increasing basal metabolic rate, improving glucose uptake by muscle, and enhancing fat-burning in the liver and muscle.18

Researchers have reported that the brain and central nervous system actually run more efficiently on ketones than they do on glucose.

effortful mental activity appears to be especially expensive in the currency of glucose.

Your body will not burn fat while your insulin level is high. It’s focused on using glucose. But once all of the glucose and glycogen is used, the insulin level falls

Fatty liver is a completely reversible process. Emptying the liver of its surplus glucose and dropping insulin levels returns the liver to normal. Hyperinsulinemia drives DNL, which is the primary determinant of fatty liver disease. Normalizing insulin levels reverses the fatty liver. Refined carbohydrates, which cause large increases in insulin, are far more sinister than dietary fat. High carbohydrate intake can increase DNL tenfold, whereas high fat consumption, with correspondingly low carbohydrate intake, does not change hepatic fat production

…Sugar has become an ingredient avoidable in prepared and packaged foods only by concerted and determined effort, effectively ubiquitous. Not just in the obvious sweet foods (candy bars, cookies, ice creams, chocolates, sodas, juices, sports and energy drinks, sweetened iced tea, jams, jellies, and breakfast cereals both cold and hot), but also in peanut butter, salad dressings, ketchup, BBQ sauces, canned soups, cold cuts, luncheon meats, bacon, hot dogs, pretzels, chips, roasted peanuts, spaghetti sauces, canned tomatoes, and breads. From the 1980's onward manufacturers of products advertised as uniquely healthy because they were low in fat…not to mention gluten free, no MSG, and zero grams trans fat per serving, took to replacing those fat calories with sugar to make them equally…palatable and often disguising the sugar under one or more of the fifty plus names, by which the fructose-glucose combination of sugar and high-fructose corn syrup might be found. Fat was removed from candy bars sugar added, or at least kept, so that they became health food bars. Fat was removed from yogurts and sugars added and these became heart healthy snacks, breakfasts, and lunches.

In our 14,384 oral glucose tolerances with insulin assays, there were 5,128 or 36 percent with lowered glucose levels after the first hour of peaking. The glucose levels were between 20 and 59 mg/dl.

During calorie restriction and fasting, blood glucose and insulin levels decline precipitously.18 Lower insulin signaling decreases growth signaling but extends life span in several species of animals.19

Fructose, which is often paired with glucose, is naturally present in fruit and honey, as well as table sugar (sucrose, which is 50 percent fructose). Assuming your baker used plenty of sugar, your cake probably has a fair amount of fructose. Unlike glucose, which can be metabolized (essentially burned) by cells throughout the body, fructose is almost entirely metabolized by the liver. The liver, however, can burn only so much fructose at once, so it converts any excess fructose into fat, which again is either stored in the liver or dumped into the bloodstream. As we will see, both of these fates cause problems.

Insulin tells the body to stop burning its fat stores and instead absorb some of the fatty acids and glucose in the blood and turn them into more body fat…but that’s not what causes you to get fatter over time—overeating does. •

In fact, according to physicians, the functioning of the digestion depends less on the brain than on hormonal mechanisms and autoregulators. However, during a fast, the digestive system gets an increasing rest. About ten hours after a meal, the contractions stop and the feeling of hunger disappears; five or six hours later the glucose stops coming directly from the intestines and begins to produce itself from the reserve of glycogen contained in the liver. From then on, the body works on itself in a closed circuit, becoming itself the source of the energy it uses. Instead of destroying an appropriating to himself nourishment taken from outside, man enters a state of nonviolence and detachment relative to the outside world.

The problem with refined grains is once again the processing, which basically “takes the life out” of the food. It strips out the nutrients and breaks down the food, making it more like an injection of glucose than something you need to digest.

Insulin’s effects on calorie storage are so potent that we can consider it the ultimate fat cell fertilizer. For example, rats given insulin infusions developed low blood glucose (hypoglycemia), ate more, and gained weight. Even when their food was restricted to that of the control animals, they still became fatter.9 Conversely, mice genetically engineered to produce less insulin had healthier fat cells, burned off more calories, and resisted weight gain, even when given a diet that makes normal mice fat.10

I would have swallowed,” she says in a slightly piqued tone. “I know, Goldie.” I sigh. I pull off my own T-shirt and regretfully wipe off the come. “But I don’t know what the carb content of my stuff is, and I didn’t want to fuck up your glucose measurements.

Though it accounts for only 2 percent of the body’s mass, it uses up a fifth of all the oxygen we breathe, and it’s where a quarter of all our glucose gets burned. The brain is the most energetically expensive piece of equipment in our body, and has been ruthlessly honed by natural selection to be efficient at the tasks for which it evolved. One might say that the whole point of our nervous system, from the sensory organs that feed information to the glob of neurons that interprets it, is to develop a sense of what is happening in the present and what will happen in the future, so that we can respond in the best possible way. Strip away the emotions, the philosophizing, the neuroses, and the dreams, and our brains, in the most reductive sense, are fundamentally prediction and planning machines.

There is new research being conducted having to do with starving cancer cells through fasting. Cancer cells can only utilize glucose, and not glycogen or ketone bodies. Moreover, cancer cells are 20–30 times less efficient at glucose utilization than normal cells. Cancer cells are real sugar addicts.

While it may be in vogue to vilify high-fructose corn syrup, which is 55 percent fructose and 45 percent glucose, it’s worth pointing out that good old table sugar (sucrose) is about the same, consisting of 50 percent fructose and 50 percent glucose. So there’s really not much of a difference between the two.

Beans contain both insoluble and soluble fiber and are very high in resistant starch. While the benefits of fiber are well-known, resistant starch is proving to be another highly desirable dietary component. Although it is technically a starch, it acts more like fiber during digestion. Typically, starches found in carbohydrate-rich foods are broken down into glucose during digestion, and the body uses that glucose as energy. Much like fiber, resistant starch “resists” digestion and passes through the small intestine without being digested. Because of this, some researchers classify resistant starch as a third type of fiber.

So, in contrast to what you may have been led to believe, eating fat doesn’t make you fat. Insulin is the primary hormone that drives the storage of fat in the fat tissues. And insulin is released not in response to dietary fat, but in response to dietary glucose. And the primary source of glucose in the modern diet is grain.

Because the insulin level in the bloodstream is determined primarily by the carbohydrates that are consumed—their quantity and quality, as I’ll discuss—it’s those carbohydrates that ultimately determine how much fat we accumulate. Here’s the chain of events: 1.  You think about eating a meal containing carbohydrates. 2. You begin secreting insulin. 3. The insulin signals the fat cells to shut down the release of fatty acids (by inhibiting HSL) and take up more fatty acids (via LPL) from the circulation. 4. You start to get hungry, or hungrier. 5. You begin eating. 6. You secrete more insulin. 7. The carbohydrates are digested and enter the circulation as glucose, causing blood sugar levels to rise.§ 8. You secrete still more insulin. 9. Fat from the diet is stored as triglycerides in the fat cells, as are some of the carbohydrates that are converted into fat in the liver. 10.  The fat cells get fatter, and so do you. 11.  The fat stays in the fat cells until the insulin level drops. If

Tightly focused attention gets fatigued—much like an overworked muscle—when we push to the point of cognitive exhaustion. The signs of mental fatigue, such as a drop in effectiveness and a rise in distractedness and irritability, signify that the mental effort needed to sustain focus has depleted the glucose that feeds neural energy.

These visceral (belly) fat cells behave differently than fat elsewhere in the body in two important ways.25 First, they are several times more sensitive to hormones and thus tend to be more metabolically active, which means they are capable of storing and releasing fat more rapidly than fat cells in other parts of the body. Second, when visceral cells release fatty acids (something fat cells do all the time), they dump the molecules almost straight into the liver, where the fat accumulates and eventually impairs the liver’s ability to regulate the release of glucose into the blood. An excess of belly fat (a paunch) is therefore a much greater risk factor for metabolic disease than a high BMI.

Why might sugar cause depression? The brain relies on glucose, a type of sugar, from the food we eat in order to survive and to function. Over a twenty-four-hour period, the brain needs only 62 grams of glucose to do its job, an incredible display of energy efficiency considering the brain has at least 100 billion cells. You can easily meet this need through

I never leave home without my cayenne pepper. I either stash a bottle of the liquid extract in my pocket book or I stick it in the shopping cart I pull around with me all over Manhattan. When it comes to staying right side up in this world, a black woman needs at least three things. The first is a quiet spot of her own, a place away from the nonsense. The second is a stash of money, like the cash my mother kept hidden in the slit of her mattress. The last is several drops of cayenne pepper, always at the ready. Sprinkle that on your food before you eat it and it’ll kill any lurking bacteria. The powder does the trick as well, but I prefer the liquid because it hits the bloodstream quickly. Particularly when eating out, I won’t touch a morsel to my lips ‘til it’s speckled with with cayenne. That’s just one way I take care of my temple, aside from preparing my daily greens, certain other habits have carried me toward the century mark. First thing I do every morning is drink four glasses of water. People think this water business is a joke. But I’m here to tell you that it’s not. I’ve known two elderly people who died of dehydration, one of whom fell from his bed in the middle of the night and couldn’t stand up because he was so parched. Following my water, I drink 8 ounces of fresh celery blended in my Vita-mix. The juice cleanses the system and reduces inflammation. My biggest meal is my first one: oatmeal. I soak my oats overnight so that when I get up all I have to do is turn on the burner. Sometimes I enjoy them with warm almond milk, other times I add grated almonds and berries, put the mixture in my tumbler and shake it until it’s so smooth I can drink it. In any form, oats do the heart good. Throughout the day I eat sweet potatoes, which are filled with fiber, beets sprinkled with a little olive oil, and vegetables of every variety. I also still enjoy plenty of salad, though I stopped adding so many carrots – too much sugar. But I will do celery, cucumbers, seaweed grass and other greens. God’s fresh bounty doesn’t need a lot of dressing up, which is why I generally eat my salad plain. From time to time I do drizzle it with garlic oil. I love the taste. I also love lychee nuts. I put them in the freezer so that when I bite into them cold juice comes flooding out. As terrific as they are, I buy them only once in awhile. I recently bit into an especially sweet one, and then I stuck it right back in the freezer. “Not today, Suzie,” I said to myself, “full of glucose!” I try never to eat late, and certainly not after nine p.m. Our organs need a chance to rest. And before bed, of course, I have a final glass of water. I don’t mess around with my hydration.

The nervous system consumes more glucose than most other parts of the body, and effortful mental activity appears to be especially expensive in the currency of glucose. When you are actively involved in difficult cognitive reasoning or engaged in a task that requires self-control, your blood glucose level drops. The effect is analogous to a runner who draws down glucose stored in her muscles during a sprint. The

For a short time, one or two hours, stress does wonderful things for the brain,” Sapolsky told the conference. “More oxygen and glucose are delivered to the brain. The hippocampus, which is involved in memory, works better when you are stressed for a little while. Your brain releases more dopamine, which plays a role in the experience of pleasure, early on during stress; it feels wonderful, and your brain works better.

Sitting here in my lab, I can imagine you scratching your head again: Dr. Panda, what’s the big deal? Aren’t we talking about just a few ounces of fat gain after a late-night snack? Won’t my metabolic rhythm come back the next day? Actually, it’s worse than you think. It is hard enough for the body to monitor hormones, genes, and clocks for someone with a strict eating routine. But when eating occurs at random times throughout the day and night, the fat-making process stays on all the time. At the same time, glucose created from digested carbohydrates floods our blood and the liver becomes inefficient in its ability to absorb glucose. If this continues for a few days, blood glucose continues to rise and reaches the danger zone of prediabetes or diabetes. So, if you’ve wondered why diets haven’t worked for you before, timing might be the reason. Even if you were diligently exercising; counting calories; avoiding fats, carbs, and sweets; and piling on the protein, it’s quite likely that you weren’t respecting your circadian clocks. If you eat late at night or start breakfast at a wildly different time each morning, you are constantly throwing your body out of sync. Don’t worry, the fix is equally simple: Just set an eating routine and stick to it. Timing is everything.

Cortisol works more systemically than adrenaline does. It triggers the liver to make more glucose available in the bloodstream while it also blocks insulin receptors in nonessential organs and tissues so that you get all the glucose (fuel) that you need to deal with the threat. Cortisol’s work is a long-term strategy of insulin resistance, which serves to provide the brain with a sustained level of glucose. However, you don’t always have a lot of glucose floating around, so cortisol works to stockpile energy. It converts protein into glycogen and begins to store fat. If the stress is chronic, the increased body fat is stored in the abdomen. If you have a growing bulge in your midsection, it may be due to cortisol working to store energy. Unfortunately, that’s not the way you want it to be stored. It’s better to burn off such stored energy by exercise.

before going out for dinner, at home, he made himself a big plate of grilled broccoli and ate it with salt and hot sauce. With broccoli in his belly, he was ready for his meal out. When he got to a restaurant, he wasn’t starving,

Anything perceived as a threat trips the amygdala—the brain’s hand-wringing sentry—to set in motion the biochemical cascade known as the fight-or-flight response. Bruce Siddle, who consults in this area and sits on the board of Strategic Operations, prefers the term “survival stress response.” Whatever you wish to call it, here is a nice, concise summary, courtesy of Siddle: “You become fast, strong, and dumb.” Our hardwired survival strategy evolved back when threats took the form of man-eating mammals, when hurling a rock superhumanly hard or climbing a tree superhumanly fast gave you the edge that might keep you alive. A burst of adrenaline prompts a cortisol dump to the bloodstream. The cortisol sends the lungs into overdrive to bring in more oxygen, and the heart rate doubles or triples to deliver it more swiftly. Meanwhile the liver spews glucose, more fuel for the feats at hand. To get the goods where the body assumes they’re needed, blood vessels in the large muscles of the arms and legs dilate, while vessels serving lower-priority organs (the gut, for example, and the skin) constrict. The prefrontal cortex, a major blood guzzler, also gets rationed. Good-bye, reasoning and analysis. See you later, fine motor skills. None of that mattered much to early man. You don’t need to weigh your options in the face of a snarling predator, and you don’t have time.

Carbohydrates are not required in a healthy human diet. Another way to say this (as proponents of carbohydrate restriction have) is that there is no such thing as an essential carbohydrate. Nutritionists will say that 120 to 130 grams of carbohydrates are required in a healthy diet, but this is because they confuse what the brain and central nervous system will burn for fuel when diets are carbohydrate rich—120 to 130 grams daily—with what we actually have to eat. If there are no carbohydrates in the diet, the brain and central nervous system will run on molecules called “ketones.” These are synthesized in the liver from the fat we eat and from fatty acids, mobilized from the fat tissue because we’re not eating carbohydrates and insulin levels are low, and even from some amino acids. With no carbohydrates in the diet, ketones will provide roughly three-quarters of the energy that our brains use. And this is why severely carbohydrate-restricted diets are known as “ketogenic” diets. The rest of the energy required will come from glycerol, which is also being released from the fat tissue when the triglycerides are broken down into their component parts, and from glucose synthesized in the liver from the amino acids in protein. Because a diet that doesn’t include fattening carbohydrates will still include plenty of fat and protein, there will be no shortage of fuel for the brain.

Lemon Water A highly effective way to detoxify the body is to drink two 16-ounce glasses of water on an empty stomach after you wake up, squeezing half of a freshly cut lemon into each glass. The lemon juice activates the water, making it better able to latch onto toxins in your body and flush them out. This is especially effective for cleansing your liver, which works all night while you’re asleep to gather and purge toxins from your body. When you wake up, it’s primed to be hydrated and flushed clean with activated water. After you drink the water, give your liver half an hour to clean up. You can then eat breakfast. If you make this into a routine, your health will improve dramatically over time. For an extra boost, add a teaspoon of raw honey and a teaspoon of freshly grated ginger to the lemon water. Your liver will draw in the honey to restore its glucose reserves, purging deep toxins at the same time to make room.

You should maintain a moderate, not high, intake of protein. When it is digested, dietary protein, such as meat, breaks down into amino acids. Adequate protein is required for good health, but excess amino acids cannot be stored in the body and so the liver converts them into glucose. Therefore, eating too much protein adds sugar to the body. So you should avoid highly processed, concentrated protein sources such as protein shakes, protein bars, and protein powders.

Corn is what feeds the steer that becomes the steak. Corn feeds the chicken and the pig, the turkey, and the lamb, the catfish and the tilapia and, increasingly, even the salmon, a carnivore by nature that the fish farmers are reengineering to tolerate corn. The eggs are made of corn. The milk and cheese and yogurt, which once came from dairy cows that grazed on grass, now typically comes from Holsteins that spend their working lives indoors tethered to machines, eating corn. Head over to the processed foods and you find ever more intricate manifestations of corn. A chicken nugget, for example, piles up corn upon corn: what chicken it contains consists of corn, of course, but so do most of a nugget's other constituents, including the modified corn starch that glues the things together, the corn flour in the batter that coats it, and the corn oil in which it gets fried. Much less obviously, the leavenings and lecithin, the mono-, di-, and triglycerides, the attractive gold coloring, and even the citric acid that keeps the nugget "fresh" can all be derived from corn. To wash down your chicken nuggets with virtually any soft drink in the supermarket is to have some corn with your corn. Since the 1980s virtually all the sodas and most of the fruit drinks sold in the supermarket have been sweetened with high-fructose corn syrup (HFCS) -- after water, corn sweetener is their principal ingredient. Grab a beer for you beverage instead and you'd still be drinking corn, in the form of alcohol fermented from glucose refined from corn. Read the ingredients on the label of any processed food and, provided you know the chemical names it travels under, corn is what you will find. For modified or unmodified starch, for glucose syrup and maltodextrin, for crystalline fructose and ascorbic acid, for lecithin and dextrose, lactic acid and lysine, for maltose and HFCS, for MSG and polyols, for the caramel color and xanthan gum, read: corn. Corn is in the coffee whitener and Cheez Whiz, the frozen yogurt and TV dinner, the canned fruit and ketchup and candies, the soups and snacks and cake mixes, the frosting and candies, the soups and snacks and cake mixes, the frosting and gravy and frozen waffles, the syrups and hot sauces, the mayonnaise and mustard, the hot dogs and the bologna, the margarine and shortening, the salad dressings and the relishes and even the vitamins. (Yes, it's in the Twinkie, too.) There are some forty-five thousand items in the average American supermarket and more than a quarter of them now contain corn. This goes for the nonfood items as well: Everything from the toothpaste and cosmetics to the disposable diapers, trash bags, cleansers, charcoal briquettes, matches, and batteries, right down to the shine on the cover of the magazine that catches your eye by the checkout: corn. Even in Produce on a day when there's ostensibly no corn for sale, you'll nevertheless find plenty of corn: in the vegetable wax that gives the cucumbers their sheen, in the pesticide responsible for the produce's perfection, even in the coating on the cardboard it was shipped in. Indeed, the supermarket itself -- the wallboard and joint compound, the linoleum and fiberglass and adhesives out of which the building itself has been built -- is in no small measure a manifestation of corn.

There is simply no compelling reason we know of to explain why human brains got large,’ says Tattersall. Huge brains are demanding organs: they make up only 2 per cent of the body’s mass, but devour 20 per cent of its energy42. They are also comparatively picky in what they use as fuel. If you never ate another morsel of fat, your brain would not complain because it won’t touch the stuff. It wants glucose instead, and lots of it, even if it means short-changing other organs.

If we lack new sources of glucose, the brain’s preferred fuel, the liver converts our fat into ketone bodies, as an alternative energy source that can sustain us for a very long time, depending on the extent of our fat stores. (Unlike muscle or liver, the brain itself does not store energy.) When our fat runs out, we will begin to consume our own muscle tissue, then our other organs, and even bone, all in order to keep the brain running at all costs. The brain is the last thing to shut off.

The conditions in the womb—in the intrauterine environment—influence the development of the fetus, so that subtly different conditions will lead, in effect, to the birth of newborns who respond differently to the environment they face outside the womb. In particular, the nutrients that the developing child receives in the womb—including the supply of glucose—pass across the placenta in proportion to the nutrient concentration in the mother’s circulation. The higher the mother’s blood sugar, the greater the supply of glucose to the fetus. The developing pancreas responds by overproducing insulin-secreting cells. “The baby is not diabetic,” says Boyd Metzger, who studies diabetes and pregnancy at Northwestern University, “but the insulin-producing cells in the pancreas are stimulated to function and grow in size and number by the environment they’re in. So they start overfunctioning. That in turn leads to a baby laying down more fat, which is why the baby of a diabetic mother is typified by being a fat baby.

Your body can pack about 400 grams (14 ounces) of glycogen into liver and muscle cells. A gram of carbohydrates — including glucose — has four calories. If you add up all the glucose stored in glycogen to the small amount of glucose in your cells and blood, it equals about 1,800 calories of energy. If your diet provides more carbohydrates than you need to produce this amount of stored calories in the form of glucose and glycogen in your cells, blood, muscles, and liver, the excess will be converted to fat. And that’s how

If blood-sugar levels increase—say, after a meal containing carbohydrates—then more glucose is transported into the fat cells, which increases the use of this glucose for fuel, and so increases the production of glycerol phosphate. This is turn increases the conversion of fatty acids into triglycerides, so that they’re unable to escape into the bloodstream at a time when they’re not needed. Thus, elevating blood sugar serves to decrease the concentration of fatty acids in the blood, and to increase the accumulated fat in the fat cells.

Below are recommended optimal ranges for key metabolic blood tests. Falling outside of these ranges is an indicator that you could have brewing dysfunction. The remainder of Part 2 and the plan in Part 3 will give specific steps to increase Good Energy and improve these biomarkers: Triglycerides: Less than 80 mg/dL HDL: 50 to 90 mg/dL Fasting Glucose: 70 to 85 mg/dL Blood Pressure: Less than 120 systolic and less than 80 diastolic mmHg Waist Circumference: <80 cm (31.5 inches) for women and <90 cm (35 inches) for men (South Asian, Chinese, Japanese, and South and Central Americans) <80 cm (31.5 inches) for women and <94 cm (37 inches) for men (European, Sub-Saharan African, Middle Eastern, and Eastern Mediterranean) Triglyceride-to-HDL Ratio: Below 1.5. Above 3 is a clear sign of metabolic dysfunction. Fasting Insulin: From 2 to 5 mIU/L. Above 10 mIU/L is concerning and above 15 mIU/L is significantly elevated. HOMA-IR: Less than 2.0 High-Sensitivity CRP (hsCRP): Less than 0.3 mg/dL Hemoglobin A1c: From 5.0 to 5.4 percent Uric Acid: Less than 5 mg/dL for men, and from 2 to 4 mg/dL for women

In other words, carbs can be seen as a far dirtier fuel than fats. When you adopt a high-fat, low-carb diet and make the switch to burning fat and ketones for fuel instead of glucose, your mitochondria’s exposure to oxidative damage drops by as much as 30 to 40 percent compared to when your primary source of fuel is sugar, as is typical in American diets today. This means that when you are “fat adapted”—that is, when you have made the transition to burning fat for fuel—your mitochondrial DNA, cell membranes, and protein can remain stronger, healthier, and more resilient. In order

In 1957, Pardee, Monod, and Jacob discovered that the lactose operon was controlled by a single master switch-a protein eventually called the repressor. The repressor functioned like a molecular lock. When lactose was added to the growth medium, the repressor protein sensed the lactose, altered its molecular structure, and "unlocked" the lactose-digesting and lactose-transporting genes (i.e. allowed the genes to be activated), thereby enabling a cell to metabolize lactose. When another sugar, such as glucose, was present, the lock remained intact, and no lactose-digesting genes were allowed to be activated,

From the moment we are diagnosed with any type of diabetes, we begin a part of our lives in which we are constantly graded. Constantly tested. Constantly told whether we’re doing a great job, a good job, an okay job, or a really bad job based on the numbers that show up on our glucose meter and A1C test. We are graded on what we eat or on how often we exercise. Whether we check our blood sugar regularly or rarely, and somewhere in our heads we can’t help but tell ourselves that we’re “good” or “bad” based entirely on how well we are able to accomplish this neverending to-do list throughout every single day. And that is exhausting.

The most surprising discovery made by Baumeister’s group shows, as he puts it, that the idea of mental energy is more than a mere metaphor. The nervous system consumes more glucose than most other parts of the body, and effortful mental activity appears to be especially expensive in the currency of glucose. When you are actively involved in difficult cognitive reasoning or engaged in a task that requires self-control, your blood glucose level drops. The effect is analogous to a runner who draws down glucose stored in her muscles during a sprint. The bold implication of this idea is that the effects of ego depletion could be undone by ingesting glucose, and Baumeister and his colleagues have confirmed this hypothesis in several experiments. Volunteers in one of their studies watched a short silent film of a woman being interviewed and were asked to interpret her body language. While they were performing the task, a series of words crossed the screen in slow succession. The participants were specifically instructed to ignore the words, and if they found their attention drawn away they had to refocus their concentration on the woman’s behavior. This act of self-control was known to cause ego depletion. All the volunteers drank some lemonade before participating in a second task. The lemonade was sweetened with glucose for half of them and with Splenda for the others. Then all participants were given a task in which they needed to overcome an intuitive response to get the correct answer. Intuitive errors are normally much more frequent among ego-depleted people, and the drinkers of Splenda showed the expected depletion effect. On the other hand, the glucose drinkers were not depleted. Restoring the level of available sugar in the brain had prevented the deterioration of performance. It will take some time and much further research to establish whether the tasks that cause glucose-depletion also cause the momentary arousal that is reflected in increases of pupil size and heart rate.

Myth #3: Fasting Causes Low Blood Sugar Sometimes people worry that blood sugar will fall very low during fasting and they will become shaky and sweaty. Luckily, this does not actually happen. Blood sugar level is tightly monitored by the body, and there are multiple mechanisms to keep it in the proper range. During fasting, our body begins by breaking down glycogen (remember, that’s the glucose in short-term storage) in the liver to provide glucose. This happens every night as you sleep to keep blood sugars normal as you fast overnight. FASTING ALL-STARS AMY BERGER People who engage in fasting for religious or spiritual purposes often report feelings of extreme clear-headedness and physical and emotional well-being. Some even feel a sense of euphoria. They usually attribute this to achieving some kind of spiritual enlightenment, but the truth is much more down-to-earth and scientific than that: it’s the ketones! Ketones are a “superfood” for the brain. When the body and brain are fueled primarily by fatty acids and ketones, respectively, the “brain fog,” mood swings, and emotional instability that are caused by wild fluctuations in blood sugar become a thing of the past and clear thinking is the new normal. If you fast for longer than twenty-four to thirty-six hours, glycogen stores become depleted. The liver now can manufacture new glucose in a process called gluconeogenesis, using the glycerol that’s a by-product of the breakdown of fat. This means that we do not need to eat glucose for our blood glucose levels to remain normal. A related myth is that brain cells can only use glucose for energy. This is incorrect. Human brains, unique amongst animals, can also use ketone bodies—particles that are produced when fat is metabolized—as a fuel source. This allows us to function optimally even when food is not readily available. Ketones provide the majority of the energy we need. Consider the consequences if glucose were absolutely necessary for brain function. After twenty-four hours without food, glucose stored in our bodies in the form of glycogen is depleted. At that point, we’d become blubbering idiots as our brains shut down. In the Paleolithic era, our intellect was our only advantage against wild animals with their sharp claws, sharp fangs, and bulging muscles. Without it, humans would have become extinct long ago. When glucose is not available, the body begins to burn fat and produce ketone bodies, which are able to cross the blood-brain barrier to feed the brain cells. Up to 75 percent of the brain’s energy requirements can be met by ketones. Of course, that means that glucose still provides 25 percent of the brain’s energy requirements. So does this mean that we have to eat for our brains to function?

Say Goodbye to Fingersticks & hello to Continuous Glucose Monitoring Systems Living with diabetes is a daily challenge, requiring individuals to closely monitor their blood glucose levels to maintain stable health. Fortunately, advancements in medical technology have revolutionized diabetes management, with one such innovation being Continuous Glucose Monitoring (CGM) systems. CGM has become a game-changer for diabetics, providing real-time data and insights that enable better control of blood sugar levels and, ultimately, a higher quality of life. In this article, we will explore the benefits of Continuous Glucose Monitoring and how it has transformed diabetes management for the better.

The ingestion of carbohydrates, especially the refined grains and sugars that are so prominent in the modern diet, causes a spike in blood sugar and a temporary energy boost. Then, because a glucose overdose is toxic in the bloodstream, insulin floods the bloodstream to remove any glucose you don’t burn immediately and stores it as either glycogen (in the liver and muscle tissues) or in the fat cells as triglyceride (the storage form of fat). When insulin removes glucose from your bloodstream and transports it into storage, you experience the familiar sugar crash and a craving for quick-energy carbohydrates. You have plenty of fat energy locked away in storage, but a high-insulin-producing diet prevents you from being able to access it. Instead, you become reliant on your next snack or meal for energy, and you exist in a state of carbohydrate dependency.

many (some say most) Asians, Africans, Middle Easterners, South Americans, and Eastern, Central, or Southern Europeans are deficient in lactase, the enzyme that splits lactose (milk sugar) into glucose and galactose. If these people drink milk or eat milk products, they end up with a lot of undigested lactose in their intestinal tracts. This undigested lactose makes the bacteria living there happy as clams — but not the person who owns the intestines: As bacteria feast on the undigested sugar, they excrete waste products that give their host gas and cramps. To avoid this anomaly, many national cuisines purposely avoid milk as an ingredient. (Quick! Name one native Asian dish that’s made with milk. No, coconut milk doesn’t count.) To get the calcium their bodies need, these people simply substitute high-calcium foods such as greens or calcium-enriched soy products for milk.

The fact that early languages, no matter how many there are, utilize the same streams implies that the brain doesn't have a native language. The brain can only reflect the fact that a set of neural circuits was built and activated for a certain period of time. Nor does the brain care if those neural circuits map onto things that the rest of the world calls languages or dialects. It really cares only about what activates those circuits. Thus, the brain patters that typify language use across skill levels can be mapped. Brain imaging technology monitors the intensity of oxygen use around the brain - higher oxygen use represents higher energy use by cells burning glucose. The deeply engrained language circuits will create dim MRI images, because they are working efficiently, requiring less glucose overall. More recently acquired languages, as well as those used less frequently, would make neural circuits shine more brightly, because they require more brain cells, thus more glucose.

Flow is an extremely potent response to external events and requires an extraordinary set of signals. The process includes dopamine, which does more than tune signal-to-noise ratios. Emotionally, we feel dopamine as engagement, excitement, creativity, and a desire to investigate and make meaning out of the world. Evolutionarily, it serves a similar function. Human beings are hardwired for exploration, hardwired to push the envelope: dopamine is largely responsible for that wiring. This neurochemical is released whenever we take a risk or encounter something novel. It rewards exploratory behavior. It also helps us survive that behavior. By increasing attention, information flow, and pattern recognition in the brain, and heart rate, blood pressure, and muscle firing timing in the body, dopamine serves as a formidable skill-booster as well. Norepinephrine provides another boost. In the body, it speeds up heart rate, muscle tension, and respiration, and triggers glucose release so we have more energy. In the brain, norepinephrine increases arousal, attention, neural efficiency, and emotional control. In flow, it keeps us locked on target, holding distractions at bay. And as a pleasure-inducer, if dopamine’s drug analog is cocaine, norepinephrine’s is speed, which means this enhancement comes with a hell of a high. Endorphins, our third flow conspirator, also come with a hell of a high. These natural “endogenous” (meaning naturally internal to the body) opiates relieve pain and produce pleasure much like “exogenous” (externally added to the body) opiates like heroin. Potent too. The most commonly produced endorphin is 100 times more powerful than medical morphine. The next neurotransmitter is anandamide, which takes its name from the Sanskrit word for “bliss”—and for good reason. Anandamide is an endogenous cannabinoid, and similarly feels like the psychoactive effect found in marijuana. Known to show up in exercise-induced flow states (and suspected in other kinds), this chemical elevates mood, relieves pain, dilates blood vessels and bronchial tubes (aiding respiration), and amplifies lateral thinking (our ability to link disparate ideas together). More critically, anandamide also inhibits our ability to feel fear, even, possibly, according to research done at Duke, facilitates the extinction of long-term fear memories. Lastly, at the tail end of a flow state, it also appears (more research needs to be done) that the brain releases serotonin, the neurochemical now associated with SSRIs like Prozac. “It’s a molecule involved in helping people cope with adversity,” Oxford University’s Philip Cowen told the New York Times, “to not lose it, to keep going and try to sort everything out.” In flow, serotonin is partly responsible for the afterglow effect, and thus the cause of some confusion. “A lot of people associate serotonin directly with flow,” says high performance psychologist Michael Gervais, “but that’s backward. By the time the serotonin has arrived the state has already happened. It’s a signal things are coming to an end, not just beginning.” These five chemicals are flow’s mighty cocktail. Alone, each packs a punch, together a wallop.

Now, for breakfast, she has oatmeal with ground flax seeds, hemp seeds, nuts, pea protein powder, and a sausage on the side. At lunchtime, two hard-boiled eggs, carrot sticks, celery, peanut butter or avocado, a protein smoothie (with collagen powder, 1 tablespoon of chia seeds, half a tablespoon of coconut oil, and a whole bunch of greens), and half a banana last. For a snack in the afternoon, Greek yogurt, berries, and half a protein bar. Finally, at dinner, fish or chicken, kale sautéed with avocado oil, and roasted sweet potatoes.

Let’s consider what happens to our metabolism when we eat carbohydrate, or, in particular, the carbohydrate in grains. Most of the carbohydrate contained in grains exists in the form of starch, which is just a large chain of glucose molecules. Starch is quickly broken down into its individual glucose units by enzymes in our saliva and those released by the pancreas. The glucose is then absorbed into the blood, causing a rise in “blood sugar.” The spike in blood sugar triggers the release of insulin from the pancreas, a hormone whose primary function is to remove glucose from the bloodstream by facilitating its transport into the bodily tissues. Once inside the tissues, the glucose can then be burned for energy. Once those tissues have their fill of glucose, however, any that’s left over in the blood must still be eliminated. Glucose that stays around too long ends up sticking to bodily tissues and causing irreversible damage. So how does our body get rid of this excess glucose? It stores it…as fat. Yes, that’s right. Any starch you consume that’s in excess of what your body needs is, under the direction of insulin, converted to fat. And, in addition to driving the storage of glucose as fat, insulin also suppresses the release of fat from the adipose tissue.