Genetic Disease Quotes

The total amount of suffering per year in the natural world is beyond all decent contemplation. During the minute that it takes me to compose this sentence, thousands of animals are being eaten alive, many others are running for their lives, whimpering with fear, others are slowly being devoured from within by rasping parasites, thousands of all kinds are dying of starvation, thirst, and disease. It must be so. If there ever is a time of plenty, this very fact will automatically lead to an increase in the population until the natural state of starvation and misery is restored. In a universe of electrons and selfish genes, blind physical forces and genetic replication, some people are going to get hurt, other people are going to get lucky, and you won't find any rhyme or reason in it, nor any justice. The universe that we observe has precisely the properties we should expect if there is, at bottom, no design, no purpose, no evil, no good, nothing but pitiless indifference.

Family," she announced. "They're the people in your life you don't get to pick. The ones that are given to you,as opposed to those you get to choose." "You're bound to them by blood," she continued, her voice flat. "Which, you know, gives you that much more in common. Diseases, genetics, hair, and eye color. It's like they're part of your blueprint. If something's wrong with you, you can usually trace it back to them." I nodded and kept writing. "But," she said, "even though you're stuck with them, at the same time, they're also stuck with you. So that's why they always get the front rows at christenings and funerals. Because they're the ones that are there, you know, from the beginning to the end. Like it or not.

People with family histories of alcoholism tend to have lower levels of endorphins- the endogenous morphine that is responsible for many of our pleasure responses- than do people genetically disinclined to alcoholism. Alcohol will slightly raise the endorphin level of people without the genetic basis for alcoholism; it will dramatically raise the endorphin level of people with that genetic basis. Specialists spend a lot of time formulating exotic hypotheses to account for substance abuse. Most experts point out, strong motivations for avoiding drugs; but there are also strong motivations for taking them. People who claim not to understand why anyone would get addicted to drugs are usually people who haven't tried them or who are genetically fairly invulnerable to them.

People don't want to accept the responsibility for their own weakness, so they place the blame on something that they're not responsible for, like disease or genetics.

The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. —Bert Vogelstein

Psychiatrists look for twisted molecules and defective genes as the causes of schizophrenia, because schizophrenia is the name of a disease. If Christianity or Communism were called diseases, would they then look for the chemical and genetic “causes” of these “conditions”?

Settling for the view that illnesses, mental or physical, are primarily genetic allows us to avoid disturbing questions about the nature of the society in which we live. If “science” enables us to ignore poverty or man-made toxins or a frenetic and stressful social culture as contributors to disease, we can look only to simple answers: pharmacological and biological.

True, science has conquered many diseases, broken the genetic code, and even placed human beings on the moon, and yet when a man of eighty is left in a room with two eighteen-year-old cocktail waitresses nothing happens.

It is my belief that the basic knowledge that we're providing to the world will have a profound impact on the human condition and the treatments for disease and our view of our place on the biological continuum.

The defining feature of a major depression is loss of pleasure. If I had to define a major depression in a single sentence, I would describe it as a “genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.

Incurable diseases will eventually force mankind to justify disruptive nanotech and genetic engineering.

Because of patent licensing fees, it costs $25,000 for an academic institution to license the gene for researching a common blood disorder, hereditary haemochromatosis, and up to $250,000 to license the same gene for commercial testing. At that rate, it would cost anywhere from $46.4 million (for academic institutions) to $464 million (for commercial labs) to test one person for all known genetic diseases.

Sometimes the greatest scientific breakthroughs happen because someone ignores the prevailing pessimism.

Happiness is a wonderful goal for those who are inclined on a genetic level toward that emotional end of the spectrum. Happiness is a treadmill of a goal for people who are not happy by nature. Being an unhappy person does not mean you must be sad or dark. You can be interested instead of happy. You can be fascinated instead of happy.

In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic stress, microbes, toxins, and allergens, all of which wash over our DNA causing changes in our gene expression, and turning off or on different genes and messages that affect our metabolism.

Today, we have discovered that everyone is born with dozens of genetic glitches. There are no perfect human specimens. But not all our glitches are the same, so one treatment often does not fit all sufferers of a given disease.

No easy way out. No escape. From yourself. You had to LEARN to DEAL with the cards you were dealt. Had to learn the hard way that the world doesn't OWE you a fucking thing. Not a reason, nor excuse. No apologies. Had to learn that some forms of insanity run in the family, pure genetics, polluted lifelines, full of disease. Profanity. Addiction. Co-addiction. Inability to deal with reality, what the fuck ever that's suppose to mean when you're born into an emotional ghetto of endless abuse. Where the only way out is in...deep, deep inside, so you poke holes in your skin, thinking that if you could just concentrate the pain it wouldn't remain an all-consuming surround which suffocates you from the first breath of day to your last dying day. Day in. Day out. Day in. Day out. I knew all about it.

Anything with blood in it can probably go bad. Like meat. And it’s the blood that makes me worry. It carries things you don’t even know you got.

The calcium in your bones came from a star. We are all made from recycled bits and pieces of the universe. This matters because origins matter. For example, if you were born to a reigning monarch but kidnapped by the black market baby underground shortly after birth and sent to America where you were raised by common, unremarkable people from Ohio, and when you were in your thirties working as a humble UPS driver, dignitaries landed their helicopter on the roof of your crummy apartment building and informed you of their thirty-plus year search for you, His Royal Highness, the course of your life might change. You know? Our familial genetic origins -medical histories- inform us of medical conditions which exist in our families and when we know about these specific conditions, we can sometimes take certain actions to prevent them. Which is why I think it’s important to consider that billions of years before we were students and mothers and dog trainers and priests, we were particles that would form into star after star after star until forever passed, and instead of a star what formed was life; simplistic, crude, miraculous. And after another infinity, there we were. And this is why for you, anything is possible. Because you are made out of everything.

intelligent fool can make things bigger and more complex ... It takes a touch of genius and a lot of courage to move in the opposite direction. —Albert Einstein Autobiographical Notes

Old measures of health not only have failed to improve significantly but have stayed the same: some have even worsened. Mainstream newspapers and magazines often report disease in an ethnocentric manner that shrouds its true cost among African Americans. For example, despite the heavy emphasis on genetic ailments among blacks, fewer than 0.5 percent of black deaths—that’s less than one death in two hundred—can be attributed to hereditary disorders such as sickle-cell anemia. A closer look at the troubling numbers reveals that blacks are dying not of exotic, incurable, poorly understood illnesses nor of genetic diseases that target only them, but rather from common ailments that are more often prevented and treated among whites than among blacks.

Making Genetic Changes We used to think that genes created disease and that we were at the mercy of our DNA. So if many people in someone’s family died of heart disease, we assumed that their chances of also developing heart disease would be pretty high. But we now know through the science of epigenetics that it’s not the gene that creates disease but the environment that programs our genes to create disease—and not just the external environment outside our body (cigarette smoke or pesticides, for example), but also the internal environment within our body: the environment outside our cells. What do I mean by the environment within our body? As I said previously, emotions are chemical feedback, the end products of experiences we have in our external environment. So as we react to a situation in our external environment that produces an emotion, the resulting internal chemistry can signal our genes to either turn on (up-regulating, or producing an increased expression of the gene) or to turn off (down-regulating, or producing a decreased expression of the gene). The gene itself doesn’t physically change—the expression of the gene changes, and that expression is what matters most because that is what affects our health and our lives.

Our recent divergence from a small population explains another important fact, one that every human ought to know: we are a genetically homogenous species.

...it is entirely illogical to consider biology in dichotomous terms of genes and environment—all of biology is based on the continuous interaction of both.

I think knowledge is a blessing, not a curse. This is especially true in the case of genetic knowledge. To understand the molecular nature of cancer for the first time, to diagnose and prevent Alzheimer’s disease, to discover the secrets of human history, to reconstruct the organisms that populated the pre-Cambrian seas – these seem to me to be immense blessings.

the genes of modern-day Africans are a treasure house for all humanity. They possess our species’ greatest reservoir of genetic diversity, of which further study will shed new light on the heredity of the human body and mind. Perhaps the time has come, in light of this and other advances in human genetics, to adopt a new ethic of racial and hereditary variation, one that places value on the whole of diversity rather than on the differences composing the diversity. It would give proper measure to our species’ genetic variation as an asset, prized for the adaptability it provides all of us during an increasingly uncertain future. Humanity is strengthened by a broad portfolio of genes that can generate new talents, additional resistance to diseases, and perhaps even new ways of seeing reality. For scientific as well as for moral reasons, we should learn to promote human biological diversity for its own sake instead of using it to justify prejudice and conflict.

A closer look at the troubling numbers reveals that blacks are dying not of exotic, incurable, poorly understood illnesses nor of genetic diseases that target only them, but rather from common ailments that are more often prevented and treated among whites than among blacks. Three

Imagine a person who enjoys alcohol, perhaps a bit too much. He has a quick three or four drinks. His blood alcohol level spikes sharply. This can be extremely exhilarating, particularly for someone who has a genetic predisposition to alcoholism.23 But it only occurs while blood alcohol levels are actively rising, and that only continues if the drinker keeps drinking. When he stops, not only does his blood alcohol level plateau and then start to sink, but his body begins to produce a variety of toxins, as it metabolizes the ethanol already consumed. He also starts to experience alcohol withdrawal, as the anxiety systems that were suppressed during intoxication start to hyper-respond. A hangover is alcohol withdrawal (which quite frequently kills withdrawing alcoholics), and it starts all too soon after drinking ceases. To continue the warm glow, and stave off the unpleasant aftermath, the drinker may just continue to drink, until all the liquor in his house is consumed, the bars are closed and his money is spent. The next day, the drinker wakes up, badly hungover. So far, this is just unfortunate. The real trouble starts when he discovers that his hangover can be “cured” with a few more drinks the morning after. Such a cure is, of course, temporary. It merely pushes the withdrawal symptoms a bit further into the future. But that might be what is required, in the short term, if the misery is sufficiently acute. So now he has learned to drink to cure his hangover. When the medication causes the disease, a positive feedback loop has been established.

One of the more exciting benefits of good nutrition is the prevention of diseases that are thought to be due to genetic predisposition. We now know that we can largely avoid these “genetic” diseases even though we may harbor the gene (or genes) that is (are) responsible for the disease.

If the history of the last century taught us the dangers of empowering governments to determine genetic “fitness” (i.e., which person fits within the triangle, and who lives outside it), then the question that confronts our current era is what happens when this power devolves to the individual. It is a question that requires us to balance the desires of the individual— to carve out a life of happiness and achievement, without undue suffering— with the desires of a society that, in the short term, may be interested only in driving down the burden of disease and the expense of disability. And operating silently in the background is a third set of actors: our genes themselves, which reproduce and create new variants oblivious of our desires and compulsions— but, either directly or indirectly, acutely or obliquely, influence our desires and compulsions. Speaking at the Sorbonne in 1975, the cultural historian Michel Foucault once proposed that “a technology of abnormal individuals appears precisely when a regular network of knowledge and power has been established.” Foucault was thinking about a “regular network” of humans. But it could just as easily be a network of genes.

Hammond shook his head sadly. “Yet, you’ll remember,” he said, “the original genetic engineering companies, like Genentech and Cetus, were all started to make pharmaceuticals. New drugs for mankind. Noble, noble purpose. Unfortunately, drugs face all kinds of barriers. FDA testing alone takes five to eight years—if you’re lucky. Even worse, there are forces at work in the marketplace. Suppose you make a miracle drug for cancer or heart disease—as Genentech did. Suppose you now want to charge a thousand dollars or two thousand dollars a dose. You might imagine that is your privilege. After all, you invented the drug, you paid to develop and test it; you should be able to charge whatever you wish. But do you really think that the government will let you do that? No, Henry, they will not. Sick people aren’t going to pay a thousand dollars a dose for needed medication—they won’t be grateful, they’ll be outraged. Blue Cross isn’t going to pay it. They’ll scream highway robbery. So something will happen. Your patent application will be denied. Your permits will be delayed. Something will force you to see reason—and to sell your drug at a lower cost. From a business standpoint, that makes helping mankind a very risky business. Personally, I would never help mankind.

Sturtevant’s rudimentary genetic map would foreshadow the vast and elaborate efforts to map genes along the human genome in the 1990s. By using linkage to establish the relative positions of genes on chromosomes, Sturtevant would also lay the groundwork for the future cloning of genes tied to complex familial diseases, such as breast cancer, schizophrenia, and Alzheimer’s disease. In about twelve hours, in an undergraduate dorm room in New York, he had poured the foundation for the Human Genome Project.

Congenital disease can warp the heart with great variety. Valves can be sealed tight, missing parts—or absent altogether. Major vessels can be misplaced, narrowed, or blocked completely. A chamber can be too small or missing, a wall too thick or thin. The heart’s electrical system—its nerves—may go haywire. The muscle can be weak. Holes may occur almost anywhere, in almost any size. Studying heart pathology, one is reminded that the genetic symphony that produces a normal baby is indeed a wondrous and delicate one.

To see what everyone else has seen but to think what nobody else has thought

We are what our genetics say we are. Melissa Mae Palmer on being born with one of the rarest diseases in history and possessing the only genetic living code.

In evolutionary terms, that means we asked for it.

Children who eat breakfast are statistically more likely to do well at school than children who skip breakfast.

You could make iPS cells by introducing just four genes into a differentiated cell.

hemophilia is an inherited blood-clotting deficiency, transmitted by women according to the sex-linked recessive Mendelian pattern. Thus, while women carry the defective genes, they almost never suffer from the disease. With rare exceptions, it strikes only males. Yet it does not necessarily strike all the males in a family. Genetically as well as clinically, hemophilia is capricious.

Every genetic “illness” is a mismatch between an organism’s genome and its environment. In some cases, the appropriate medical intervention to mitigate a disease might be to alter the environment to make it “fit” an organismal form (building alternative architectural realms for those with dwarfism; imagining alternative educational landscapes for children with autism). In other cases, conversely, it might mean changing genes to fit environments. In yet other cases, the match may be impossible to achieve: the severest forms of genetic illnesses, such as those caused by nonfunction of essential genes, are incompatible with all environments. It is a peculiar modern fallacy to imagine that the definitive solution to illness is to change nature—i.e., genes—when the environment is often more malleable. 10.

The human has genetic adaptation to natural electromagnetic radiation. Increasing, reducing or removing the natural radiation exposures results in a sickened human that may progress onto a diseased state.

People in here, People everywhere, they all want to take their own problems, usually created by themselves, and try to pass them off on someone or something else. I know my Mother and Father did the best they could and gave me the best they could and loved me the best they could and if anything, they are victims of me. I could say I'm flawed in my genetic makeup, that I have this disease and my addictions are caused by the presence of it, but I think that's a load of shit. I'm a victim of nothing but myself, just as I believe that most People with this so-called disease aren't victims of anything other than themselves. If you want to call that philosophy stubbornness, go right ahead. I call it being responsible. I call it the acceptance of my own problems and my own weakness with honor and dignity. I call it getting better.

Because race is not a biological reality, medications based upon group biological differences will work only for some African Americans. This will lead to a false sense of security, and will stymie the search for more inclusive, more efficacious, and, in a word, better treatments. We must recognize the powerful stigmatizing potential of genetic approaches to disease, especially when they are touted as the only approach.

Once a virus gets into an intensive poultry shed it can move quickly through the flock, constantly replicating itself. Any ‘errors’ or changes to the genetic code during replication don’t get repaired: this is how the virus mutates and new variant strains emerge. The tragedy is that while intensive farms provide ideal conditions for the emergence of new aggressive disease strains, wild birds can then become infected too. Experience

Back in the 1980s, there was enormous enthusiasm about gene therapy, i.e., repairing broken genes. There are at least 10,000 known genetic diseases afflicting the human race. There was a belief that science would enable us to rewrite the code of life, correcting the mistakes of Mother Nature. There was even talk that gene therapy might be able to enhance the human race as well, improving our health and intelligence at the genetic level.

We face no such difficulty if we see that what is being transmitted genetically is not ADD or its equally ill-mannered and discombobulating relatives, but sensitivity. The existence of sensitive people is an advantage for humankind because it is this group that best expresses humanity’s creative urges and needs. Through their instinctual responses the world is best interpreted. Under normal circumstances, they are artists or artisans, seekers, inventors, shamans, poets, prophets. There would be valid and powerful evolutionary reasons for the survival of genetic material coding for sensitivity. It is not diseases that are being inherited but a trait of intrinsic survival value to human beings. Sensitivity is transmuted into suffering and disorders only when the world is unable to heed the exquisitely tuned physiological and psychic responses of the sensitive individual.

Every textbook description of a disease should have, in our opinion, a section devoted to its evolutionary aspects. This section should address the following questions: 1. Which aspects of the syndrome are direct manifestations of the disease, and which are actually defenses? 2. If the disease has a genetic component, why do the responsible genes persist? 3. Do novel environmental factors contribute to the disease? 4. If the disease is related

Willpower doesn’t change everything. We can’t be just anything we want to be. My mother couldn’t will herself to be like she was when she was thirty or forty. She couldn’t choose to be normal — her muscles were degenerating.

In some environments in the universe, the most efficient way for humans to thrive might be to alter their own genes. Indeed, we are already doing that in our present environment, to eliminate diseases that have in the past blighted many lives. Some people object to this on the grounds (in effect) that a genetically altered human is no longer human. This is an anthropomorphic mistake. The only uniquely significant thing about humans (whether in the cosmic scheme of things or according to any rational human criterion) is our ability to create new explanations, and we have that in common with all people. You do not become less of a person if you lose a limb in an accident; it is only if you lose your brain that you do. Changing our genes in order to improve our lives and to facilitate further improvements is no different in this regard from augmenting our skin with clothes or our eyes with telescopes.

The greatest disease of mankind is a lack of love for children, leading to their psychological and sometimes even physical abuse, which predisposes those children to a hopeless-helpless attitude and to disease later in life. We cannot keep blaming physical poisons or genetic defects for every disease. We have to realize that there are social and psychosocial poisons in our own homes that predispose us to disease by creating certain attitudes and feelings within us.

But for years questions persisted about whether most cannibalism was religiously motivated and selective or culinary and routine. DNA suggests routine. Every known ethnic group worldwide has one of two genetic signatures that help our bodies fight off certain diseases that cannibals catch, especially mad-cow-like diseases that come from eating each other’s brains. This defensive DNA almost certainly wouldn’t have become fixed worldwide if it hadn’t once been all too necessary.

McKusick's belief in this paradigm-the focus on disability rather than abnormalcy-was actualized in the treatment of patients in his clinic. Patients with dwarfism, for instance, were treated by an interdisciplinary team of genetic counselors, neurologists, orthopedic surgeons, nurses, and psychiatrists trained to focus on specific disabilities of persons with short stature. Surgical interventions were reserved to correct specific deformities as they arose. The goal was not to restore "normalcy"-but vitality, joy, and function. McKusic had rediscovered the founding principles of modern genetics in the realm of human pathology. In humans as in wild flies, genetic variations abounded. Here too genetic variants, environments, and gene-environment interactions ultimately collaborated to cause phenotypes-except in this case, the "phenotype" in question was disease. Here too some genes had partial penetrance and widely variable expressivity. One gene could cause many diseases, and one disease could be caused by many genes. And here too "fitness" could not be judged in absolutes. Rather the lack of fitness-illness [italicized, sic] in colloquial terms- was defined by the relative mismatch between an organism and environment.

The language of cancer is grammatical, methodical, and even—I hesitate to write—quite beautiful. Genes talk to genes and pathways to pathways in perfect pitch, producing a familiar yet foreign music that rolls faster and faster into a lethal rhythm. Underneath what might seem like overwhelming diversity is a deep genetic unity. Cancers that look vastly unlike each other superficially often have the same or similar pathways unhinged. “Cancer,” as one scientist recently put it, “really is a pathway disease.

It’s not just humans who have trisomies of the sex chromosomes. One day you may be happily amazing your friends with your confident statement that their tortoiseshell cat is female when they deflate you by telling you that their pet has been sexed by the vet and is actually a Tom. At this point, smile smugly and then say ‘Oh, in that case he’s karyotypically abnormal. He has an XXY karyotype, rather than XY’. And if you’re feeling particularly mean, you can tell them that Tom is infertile. That should shut them up.

The pineal gland is activated by light and controls the body's bio- rhythms in concert with the hypothalamus gland which regulates hunger, thirst, sexual desire and the biological clock that dictates how fast we age. Look at the potential for mass control if you can externally suppress and manipulate the pineal and hypothalamus glands alone. You can make it much harder to perceive beyond the five senses, decide how quickly people age, how much they want sex, when they are hungry and thirsty and for how long. This is the key reason for putting sodium fluoride into water supplies and toothpaste. The pineal gland absorbs more fluoride than any other part of the body and becomes calcified by this highly-damaging toxin. Sodium fluoride is an appalling waste product of the aluminum industry and has been used in rat poison. It causes cancer, genetic damage, Alzheimer's disease, disrupts the endocrine system and dumbs down the brain. It was added to drinking water in the Nazi concentration camps to make the inmates more acquiescent and docile.

WHAT’S GOOD FOR THE HEART IS GOOD FOR THE BRAIN. That is, vascular health (meaning low apoB, low inflammation, and low oxidative stress) is crucial to brain health. WHAT’S GOOD FOR THE LIVER (AND PANCREAS) IS GOOD FOR THE BRAIN. Metabolic health is crucial to brain health. TIME IS KEY. We need to think about prevention early, and the more the deck is stacked against you genetically, the harder you need to work and the sooner you need to start. As with cardiovascular disease, we need to play a very long game. OUR MOST POWERFUL TOOL FOR PREVENTING COGNITIVE DECLINE IS EXERCISE. We’ve talked a lot about diet and metabolism, but exercise appears to act in multiple ways (vascular, metabolic) to preserve brain health; we’ll get into more detail in Part III, but exercise—lots of it—is a foundation of our Alzheimer’s-prevention program.

Poor health was not just the result of random acts, bad luck, bad behavior or unfortunate genetics. Deliberate public policy decision about housing, education, parks and streets were the key drivers of racial differences in mortality. Crime kept people off the streets and limited their ability to exercise. The lack of grocery stores limited dietary choices. The lack of primary care doctors and specialists in these communities made chronic disease care more difficult. The degradation and loss of hospital services in these communities affected hospital-based outcomes. … The chronic underfunding of critical health services at Cook County Hospital and other safety-net providers contributed to these poor outcomes as well. The deleterious impact of social structures such as urban poverty and racism on health has been called 'structural violence.

Did you know that the fundamental building blocks of life are not cells, are not DNA are not even carbon but language yeah 'cause DNA is just a four-character language and binary code is a two-character language and what these languages are saying is the very act of revealing, so you reach an X-point when language attains a level of complexity where it begins to fold in upon itself trying to understand itself and this is sentience. Did you know that the entire Library of Congress can be encoded in our DNA because all you have to do is translate a binary system into a four-character system to where you can decode the genes like you're searching a microfiche and if you were to genetically engineer the corpus of human knowledge into our DNA then we'd be able to genetically pass the entire library along from generation to generation like frickin' disease, man.

Drug addiction was a disease, and just as I wouldn’t judge a cancer patient for a tumor, so I shouldn’t judge a narcotics addict for her behavior. At thirteen, I found this patently absurd, and Mom and I often argued over whether her newfound wisdom was scientific truth or an excuse for people whose decisions destroyed a family. Oddly enough, it’s probably both: Research does reveal a genetic disposition to substance abuse, but those who believe their addiction is a disease show less of an inclination to resist it. Mom was telling herself the truth, but the truth was not setting her free.

There is a significant hereditary contribution to ADD but I do not believe any genetic factor is decisive in the emergence of ADD traits in any child. Genes are codes for the synthesis of the proteins that give a particular cell its characteristic structure and function. They are, as it were, alive and dynamic architectural and mechanical plans. Whether the plan becomes realized depends on far more than the gene itself. It is determined, for the most part, by the environment. To put it differently, genes carry potentials inherent in the cells of a given organism. Which of multiple potentials become expressed biologically is a question of life circumstances. Were we to adopt the medical model — only temporarily, for the sake of argument — a genetic explanation by itself would still be unsuitable. Medical conditions for which genetic inheritance are fully or even mostly responsible, such as muscular dystrophy, are rare. “Few diseases are purely genetic,” says Michael Hayden, a geneticist at the University of British Columbia and a world-renowned researcher into Huntington’s disease. “The most we can say is that some diseases are strongly genetic.” Huntington’s is a fatal degeneration of the nervous system based on a single gene that, if inherited, will almost invariably cause the disease. But not always. Dr. Hayden mentions cases of persons with the gene who live into ripe old age without any signs of the disease itself. “Even in Huntington’s, there must be some protective factor in the environment,” Dr. Hayden says.

If any field needs integration, it is medicine. If any field needs an integrative paradigm that can make sense out of all the different models of healing, it is medicine. The weaknesses of the conventional medical model have been clear for some time. Its procedures are too invasive and have too many harmful side effects. There is no conventional medical model for the treatment of most chronic and degenerative diseases (germ theory and genetic predisposition are not adequate explanations for most conditions in this category). Last, but not least, conventional medicine is expensive. In contrast, there are so many

Nobel laureate Elizabeth Blackburn is more optimistic and says, "Every sign, including genetics, says there's some causality [between telomeres] and the nasty things that happen with aging." She notes that there is a direct link between the shortened telomeres and certain diseases. For example, if you have shortened telomeres- if your telomeres are in the bottom third of the population in terms of length-then your risk of cardiovascular disease is 40 percent greater. "Telomere shortening," she concludes, "seems to underlie the risks for the diseases that kill you...heart disease, diabetes, cancer, even Alzheimer's.

Perhaps there is something within the genetic make-up of specific individuals which predisposes them to accumulate and retain aluminium in their brain, as is similarly suggested for individuals with familial Alzheimer’s disease. The new evidence strongly suggests that aluminium is entering the brain in ASD via pro-inflammatory cells which have become loaded up with aluminium in the blood and/or lymph, much as has been demonstrated for monocytes at injection sites for vaccines including aluminium adjuvants. Perhaps we now have the putative link between vaccination and ASD, the link being the inclusion of an aluminium adjuvant in the vaccine.

The single hardest burden for a human being to carry is a lack of nurturance in childhood. Physical or sexual abuse, neglect, constant criticism: in the face of such treatment, our bodies and minds brace for a tough life ahead, even down to the level of how our genes are expressed. Genetics research has revealed that our life experiences influence which of our genes will become more or less active. For example, a specific group of genes is involved in responding to stress. A lack of nurturance intensifies their activity, making us less able to handle stress and decreasing our resistance to disease. We can also experience emotional instability or emotional blunting that can be lifelong.

Mother Nature, truly we are grateful for what you have made us. No doubt you did the best you could. However, with all due respect, we must say that you have in many ways done a poor job with the human constitution. You have made us vulnerable to disease and damage. You compel us to age and die – just as we’re beginning to attain wisdom. And, you forgot to give us the operating manual for ourselves! … What you have made is glorious, yet deeply flawed … We have decided that it is time to amend the human constitution … We do not do this lightly, carelessly, or disrespectfully, but cautiously, intelligently, and in pursuit of excellence … Over the coming decades we will pursue a series of changes to our own constitution … We will no longer tolerate the tyranny of aging and death … We will expand our perceptual range … improve on our neural organization and capacity … reshape our motivational patterns and emotional responses … take charge over our genetic programming and achieve mastery over our biological and neurological processes.

When most people had to hunt, a minor genetic variation in your ability to focus attention was hardly a problem, and may even have been an advantage [enabling a hunter to maintain his focus on multiple and simultaneous targets, for instance]. When most people have to make it through high school, the same variation can become a life-altering disease.

Our best minds are not wasting their time trying to give meaning to death. Instead, they are busy investigating the physiological, hormonal and genetic systems responsible for disease and old age. They are developing new medicines, revolutionary treatments and artificial organs that will lengthen our lives and might one day vanquish the Grim Reaper himself.

with the elucidation of the genetic code in 1966, Francis Crick confidently declared vitalism dead and buried. Only it still lives on in various pseudosciences. Homeopathy is based on vitalism. Its founder Samuel Hahnemann believed that diseases ‘are solely spirit-like (dynamic) derangements of the spirit-like power (the vital principle) that animates the human body’.

Vaccinations are the application of evolutionary principles in action. If we can control the contact made between pathogen and lymphocyte populations, we can go a long way toward eliminating disease.108 It doesn’t require total annihilation but rather a control on population dynamics. Vaccines are the way we use selective cloning to keep a pathogenic population in a state of benign coexistence. The process is based on evolution, as pointed out by Nobel laureate Susumu Tonegawa: “Genes can mutate and recombine. These dynamic characteristics of genetic material are essential elements of evolution. Do they also play an important role during the development of a single multicellular organism? Our results strongly suggest that this is the case for the immune system.

In 1995, China passed the National Maternal and Infant Health Law, forbidding couples who had “genetic diseases of a serious nature” to procreate. The conditions listed include mental retardation, mental illness, and seizures. These couples were required to undergo a mandatory premarital medical exam. It was hugely controversial, reviving international criticism that China practices eugenics. Actually, the wording of the national law was considered mild. Some provinces had more explicit regulations. In 1988, Gansu Province passed local regulations prohibiting “reproduction of the dull-witted, idiots, or blockheads.” Gansu abolished that law in 2002. Similarly, the National Maternal and Infant Health Law was defanged when requirements for the premarital medical examination were quietly dropped in 2003.

The contamination of drinking water in dense urban settlements did not merely affect the number of V. cholerae circulating through the small intestines of mankind. It also greatly increased the lethality of the bacteria. This is an evolutionary principle that has long been observed in populations of disease-spreading microbes. Bacteria and viruses evolve at much faster rates than humans do, for several reasons. For one, bacterial life cycles are incredibly fast: a single bacterium can produce a million offspring in a matter of hours. Each new generation opens up new possibilities for genetic innovation, either by new combinations of existing genes or by random mutations. Human genetic change is several orders of magnitude slower; we have to go through a whole fifteen-year process of maturation before we can even think about passing our genes to a new generation.

Whether the result of wear, tear, and exhaustion of resources or whether genetically programmed, all life has a finite span and each species has its own particular longevity. For human beings, this would appear to be approximately 100 to 110 years. This means that even were it possible to prevent or cure every disease that carries people off before the ravages of senescence do, virtually no one would live beyond a century or a bit more.

The scariest thing is that nobody seems to be considering the impact on those wild fish of fish farming on the scale that is now being proposed on the coast of Norway or in the open ocean off the United States. Fish farming, even with conventional techniques, changes fish within a few generations from an animal like a wild buffalo or a wildebeest to the equivalent of a domestic cow. Domesticated salmon, after several generations, are fat, listless things that are good at putting on weight, not swimming up fast-moving rivers. When they get into a river and breed with wild fish, they can damage the wild fish's prospects of surviving to reproduce. When domesticated fish breed with wild fish, studies indicate the breeding success initially goes up, then slumps as the genetically different offspring are far less successful at returning to the river. Many of the salmon in Norwegian rivers, which used to have fine runs of unusually large fish, are now of farmed origin. Domesticated salmon are also prone to potentially lethal diseases, such as infectious salmon anemia, which has meant many thousands have had to be quarantined or killed. They are also prone to the parasite Gyrodactylus salaris, which has meant that whole river systems in Norway have had to be poisoned with the insecticide rotenone and restocked.

The problem with racial discrimination, though, is not the inference of a person's race from their genetic characteristics. It is quite the opposite: it is the inference of a person's characteristics from their race. The question is not, can you, given an individual's skin color, hair texture, or language, infer something about their ancestry or origin. That is a question of biological systematics -- of lineage, taxonomy, of racial geography, of biological discrimination. Of course you can -- and genomics as vastly refined that inference. You can scan any individual genome and infer rather deep insights about a person's ancestry, or place of origin. But the vastly more controversial question is the converse: Given a racial identity -- African or Asian, say -- can you infer anything about an individual's characteristics: not just skin or hair color, but more complex features, such as intelligence, habits, personality, and aptitude? /I/ Genes can certainly tell us about race, but can race tell us anything about genes? /i/ To answer this question, we need to measure how genetic variation is distributed across various racial categories. Is there more diversity _within_ races or _between_ races? Does knowing that someone is of African versus European descent, say, allow us to refine our understanding of their genetic traits, or their personal, physical, or intellectual attributes in a meaningful manner? Or is there so much variation within Africans and Europeans that _intraracial_ diversity dominates the comparison, thereby making the category "African" or "European" moot? We now know precise and quantitative answers to these questions. A number of studies have tried to quantify the level of genetic diversity of the human genome. The most recent estimates suggest that the vast proportion of genetic diversity (85 to 90 percent) occurs _within_ so-called races (i.e., within Asians or Africans) and only a minor proportion (7 percent) within racial groups (the geneticist Richard Lewontin had estimated a similar distribution as early as 1972). Some genes certainly vary sharply between racial or ethnic groups -- sickle-cell anemia is an Afro-Caribbean and Indian disease, and Tay-Sachs disease has a much higher frequency in Ashkenazi Jews -- but for the most part, the genetic diversity within any racial group dominates the diversity between racial groups -- not marginally, but by an enormous amount. The degree of interracial variability makes "race" a poor surrogate for nearly any feature: in a genetic sense, an African man from Nigria is so "different" from another man from Namibia that it makes little sense to lump them into the same category.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

When we focus on thoughts about bitter past memories or imagined dreadful futures to the exclusion of everything else, we prevent the body from regaining homeostasis. In truth, we’re capable of turning on the stress response by thought alone. If we turn it on and then can’t turn it off, we’re surely headed for some type of illness or disease—be it a cold or cancer—as more and more genes get downregulated in a domino effect, until we eventually arrive at our genetic destiny.

compiling the information on the number of years of education for over four hundred thousand people of European ancestry whose genomes have been surveyed in the course of various disease studies, Daniel Benjamin and colleagues identified seventy-four genetic variations each of which has overwhelming evidence of being more common in people with more years of education than in people with fewer years even after controlling for such possibly confounding factors as heterogeneity in the study population.25

The Good News: Taller, Longer-Lived, and Healthier Bodies The last 150 years have profoundly transformed how we eat, work, travel, fight disease, keep clean, and even sleep. It is as if the human species had a total makeover: our daily lives would be barely comprehensible to our ancestors from just a few generations ago, but we are essentially identical genetically, anatomically, and physiologically. The change has been so rapid that too little time has elapsed for more than a modicum of natural selection to have occurred.

This is the mitochondrial DNA.” Bowers nodded back to the cryo-case. “It’s the genetic material that actually makes the energy that powers our cells. Think of it like this. Each of our cells has the usual 23 pairs of chromosomes that make us human and determine our physical appearance, how we fight off disease, and other physical characteristics. Now think of the mitochondria as little organisms within our cells. Like cells within a cell. It’s those little organisms that make energy for our cells. And they have their own DNA.” “I

We cannot deny the existence of substantial average genetic differences across populations, not just in traits such as skin color, but also in bodily dimensions, the ability to efficiently digest starch or milk sugar, the ability to breathe easily at high altitudes, and susceptibility to particular diseases. These differences are just the beginning. I expect that the reason we don’t know about a much larger number of differences among human populations is that studies with adequate statistical power to detect them have not yet been carried out. For the great majority of traits,

There's a psychologist called Mary & Diamond who at Brooklyn in California, in the 80s studied rats. And they took rats at different ages. Newborns, some of whom they deliberately brain damaged, adult, middle-aged, elderly rats. And they exposed these rats to different levels of environmental stimulation, better food, more playmates, toys to play with and so on. They found out a couple of months later that the rats, at any age, including the brain-damaged rats, who had the better stimulation, they were smarter. But in the autopsy then they also found that in the front part of their brain they had larger nerve-cells with more connections with other nerve-cells and richer blood supply. In other words that environmental stimulation actually caused a change in the state of the brain, even in the older rats. And that's called neuroplasticity. The capacity of the brain to develop new circuits. So whether it comes to ADHD, addiction, depression or other childhood disorders or any other issue with adults as well, if we recognize them not as ingrained, genetically-determined diseases, but as problems of development, then the question becomes very different. Then the question becomes not just "how do we treat the symptoms?" (and addiction itself is a symptom, depression is a symptom), but "how do we help people develop out of these conditions?" In other words, it is not a medical question, purely, but a developmental question. And development always requires the right environment. Now, if you're a gardener you know that. If you are growing plants in your backyard and you want them to grow into healthy, functioning beings, botanical beings, you want to provide them with the right nurturing, the right nutrition, minerals, water, sunlight and so on. So the real question is how do we provide the conditions for further development for people whose development was impaired in the first place? Now we know how to do that. We are just not doing it.

SO MUCH FOR our dispassionate examination of the germ’s interests. Now let’s get back to considering our own selfish interests: to stay alive and healthy, best done by killing the damned germs. One common response of ours to infection is to develop a fever. Again, we’re used to considering fever as a “symptom of disease,” as if it developed inevitably without serving any function. But regulation of body temperature is under our genetic control and doesn’t just happen by accident. A few microbes are more sensitive to heat than our own bodies are. By raising our body temperature, we in effect try to bake the germs to death before we get baked ourselves.

So as I said, the world was mutating," she said, prick, prick, pricking at the cloth, looking up at me once to make sure, I assume, I was listening. "From the earth sprung hateful and ugly things that flourished amid all that was lush and good. There would be no more accord among the animals now; they would follow a different order, no longer subsisting exclusively on plants but also on one another. Adam's flesh was no longer the same, though it would take centuries for disease to manifest itself, for bodies so genetically pure that a man could marry his sister to corrupt down through generations to the point where a man dare not marry even his cousin.

An important attribute of metabolites is their close relationship to both the biological states of interest (i.e. disease status) and relevant genomic, transcriptomic, and proteomic variants causally related to the disease state. As such, metabo-profiles can be viewed as an intermediate measure that links pre-disposing genes and environmental exposures to a resulting disease state. Causal metabolites also typically have a stronger relationship (i.e. larger effect size) to the underlying genetics and the disease phenotype. Thus, the integration of metabolomic data into systems biology approaches may provide a missing link between genes and disease states.

Our slowest defensive response is through natural selection, which changes our gene frequencies from generation to generation. For almost any disease, some people prove to be genetically more resistant than are others. In an epidemic those people with genes for resistance to that particular microbe are more likely to survive than are people lacking such genes. As a result, over the course of history, human populations repeatedly exposed to a particular pathogen have come to consist of a higher proportion of individuals with those genes for resistance—just because unfortunate individuals without the genes were less likely to survive to pass their genes on to babies.

If you were going to start a bioengineering company, Henry, what would you do? Would you make products to help mankind, to fight illness and disease? Dear me, no. That’s a terrible idea. A very poor use of new technology.” Hammond shook his head sadly. “Yet, you’ll remember,” he said, “the original genetic engineering companies, like Genentech and Cetus, were all started to make pharmaceuticals. New drugs for mankind. Noble, noble purpose. Unfortunately, drugs face all kinds of barriers. FDA testing alone takes five to eight years—if you’re lucky. Even worse, there are forces at work in the marketplace. Suppose you make a miracle drug for cancer or heart disease—as Genentech did. Suppose you now want to charge a thousand dollars or two thousand dollars a dose. You might imagine that is your privilege. After all, you invented the drug, you paid to develop and test it; you should be able to charge whatever you wish. But do you really think that the government will let you do that? No, Henry, they will not. Sick people aren’t going to pay a thousand dollars a dose for needed medication—they won’t be grateful, they’ll be outraged. Blue Cross isn’t going to pay it. They’ll scream highway robbery. So something will happen. Your patent application will be denied. Your permits will be delayed. Something will force you to see reason—and to sell your drug at a lower cost. From a business standpoint, that makes helping mankind a very risky business. Personally, I would never help mankind.

Scientists know your DNA reflects the genetic legacy of your parents, their parents, and your ancestors. It’s possible that it also reflects their emotional experiences. As researchers learn more about our DNA, maybe we’ll find that our cells have encoded the traumas of our ancestors. Experiments in mice have shown that aversion to certain smells is passed down to the offspring after the parental mice were trained to avoid a certain smell by being shocked every time they smelled it.8 While we know that a family history of heart disease may mean close relatives share genes and genetic markers, if we look back, we can often see in family stories hearts that are broken, conflicted, and prevented from loving fully. In my family, people tend to die of heart disease prematurely. My maternal

When fat is heated to frying temperatures, whether it be animal fat, such as lard, or plant fat, such as vegetable oil, toxic volatile chemicals with mutagenic properties (those able to cause genetic mutations) are released into the air.22 This happens even before the “smoke point” temperature is reached.23 If you do fry at home, good ventilation in the kitchen may reduce lung cancer risk.24 Cancer risk may also depend on what’s being fried. A study of women in China found that smokers who stir-fried meat every day had nearly three times the odds of lung cancer compared to smokers who stir-fried foods other than meat on a daily basis.25 This is thought to be because of a group of carcinogens called heterocyclic amines that are formed when muscle tissue is subjected to high temperatures.

You and I know how to stay alive in an urban community. As humans, we are genetically encoded to adapt to many environments when given proper teaching from more experienced humans. We know not to talk to strangers, not to cross on the red light, and not to leave the doors unlocked. Most of us are more or less successful and only occasionally make a life-threatening mistake. Some of us may have an additional set of survival skills, depending on our circumstances. We can live with a debilitating disease, be shot into space and live in a capsule, or survive summer camp. After summer camp, we are still the same people we were before summer camp, except now we know write our name in our underware, not chew gum found under the bed, and to stay away from things that look like sticks but are, in fact, snakes.

Thirdly, and most importantly, American plantations in places such as Virginia, Haiti and Brazil were plagued by malaria and yellow fever, which had originated in Africa. Africans had acquired over the generations a partial genetic immunity to these diseases, whereas Europeans were totally defenceless and died in droves. It was consequently wiser for a plantation owner to invest his money in an African slave than in a European slave or indentured labourer. Paradoxically, genetic superiority (in terms of immunity) translated into social inferiority: precisely because Africans were fitter in tropical climates than Europeans, they ended up as the slaves of European masters! Due to these circumstantial factors, the burgeoning new societies of America were to be divided into a ruling caste of white Europeans and a subjugated caste of black Africans.

Healing is the initial justification for every upgrade. Find some professors experimenting in genetic engineering or brain–computer interfaces, and ask them why they are engaged in such research. In all likelihood they would reply that they are doing it to cure disease. ‘With the help of genetic engineering,’ they would explain, ‘we could defeat cancer. And if we could connect brains and computers directly, we could cure schizophrenia.’ Maybe, but it will surely not end there. When we successfully connect brains and computers, will we use this technology only to cure schizophrenia? If anybody really believes this, then they may know a great deal about brains and computers, but far less about the human psyche and human society. Once you achieve a momentous breakthrough, you cannot restrict its use to healing and completely forbid using it for upgrading.

Dr. Kary Mullis, who won the Nobel Prize in Chemistry for inventing PCR, stated publicly numerous times that his invention should never be used for the diagnosis of infectious diseases. In July of 1997, during an event called Corporate Greed and AIDS in Santa Monica CA, Dr. Mullis explained on video, “With PCR you can find almost anything in anybody. It starts making you believe in the sort of Buddhist notion that everything is contained in everything else, right? I mean, because if you can model amplify one single molecule up to something that you can really measure, which PCR can do, then there’s just very few molecules that you don’t have at least one single one of them in your body. Okay? So that could be thought of as a misuse of it, just to claim that it’s meaningful.” Mikki explained, “The major issue with PCR is that it’s easily manipulated. It functions through a cyclical process whereby each revolution amplifies magnification. On a molecular level, most of us already have trace amounts of genetic fragments similar to coronavirus within us. By simply over-cycling the process, a negative result can be flipped to a positive. Governing bodies such as the CDC and the WHO can control the number of cases by simply advising the medical industry to increase or decrease the cycle threshold (CT).” In August of 2020, the New York Times reported that “a CT beyond 34 revolutions very rarely detect live virus, but most often, dead nucleotides that are not even contagious. In compliance with guidance from the CDC and the WHO, many top US labs have been conducting tests at cycle thresholds of 40 or more. NYT examined data from Massachusetts, New York, and Nevada and determined that up to 90 percent of the individuals who tested positive carried barely any virus.”17 90 percent! In May of 2021, CDC changed the PCR cycle threshold from 40 to 28 or lower for those who have been vaccinated. This one adjustment of the numbers allowed the vaccine pushers to praise the vaccines as a big success.

By the end of this decade, permutations and combinations of genetic variants will be used to predict variations in human phenotype, illness, and destiny. Some diseases might never be amenable to such a genetic test, but perhaps the severest variants of schizophrenia or heart disease, or the most penetrant forms of familial cancer, say, will be predictable by the combined effect of a handful of mutations. And once an understanding of "process" has been built into predictive algorithms, the interactions between various gene variants could be used to compute ultimate effects on a whole host of physical and mental characteristics beyond disease alone. Computational algorithms could determine the probability of the development of heart disease or asthma or sexual orientation and assign a level of relative risk for various fates to each genome. The genome will thus be read not in absolutes, but in likelihoods-like a report card that does not contain grades but probabilities, or a resume that does not list past experiences but future propensities. It will become a manual for previvorship.

Brocq's disease was incurable until 1951 when a sixteen-year-old boy with an advanced case of the affliction was referred as a last resort to a hypnotherapist named A. A. Mason at the Queen Victoria Hospital in London. Mason discovered that the boy was a good hypnotic subject and could easily be put into a deep state of trance. While the boy was in trance, Mason told him that his Brocq's disease was healing and would soon be gone. Five days later the scaly layer covering the boy's left arm fell off, revealing soft, healthy flesh beneath. By the end of ten days the arm was completely normal. Mason and the boy continued to work on different body areas until all of the scaly skin was gone. The boy remained symptom-free for at least five years, at which point Mason lost touch with him.6 0 This is extraordinary because Brocq's disease is a genetic condition, and getting rid of it involves more than just controlling autonomic processes such as blood flow patterns and various cells of the immune system. It means tapping into the masterplan, our DNA programming itself. So, it would appear that when we access the right strata of our beliefs, our minds can override even our genetic makeup.

The main ones are the symbolists, connectionists, evolutionaries, Bayesians, and analogizers. Each tribe has a set of core beliefs, and a particular problem that it cares most about. It has found a solution to that problem, based on ideas from its allied fields of science, and it has a master algorithm that embodies it. For symbolists, all intelligence can be reduced to manipulating symbols, in the same way that a mathematician solves equations by replacing expressions by other expressions. Symbolists understand that you can’t learn from scratch: you need some initial knowledge to go with the data. They’ve figured out how to incorporate preexisting knowledge into learning, and how to combine different pieces of knowledge on the fly in order to solve new problems. Their master algorithm is inverse deduction, which figures out what knowledge is missing in order to make a deduction go through, and then makes it as general as possible. For connectionists, learning is what the brain does, and so what we need to do is reverse engineer it. The brain learns by adjusting the strengths of connections between neurons, and the crucial problem is figuring out which connections are to blame for which errors and changing them accordingly. The connectionists’ master algorithm is backpropagation, which compares a system’s output with the desired one and then successively changes the connections in layer after layer of neurons so as to bring the output closer to what it should be. Evolutionaries believe that the mother of all learning is natural selection. If it made us, it can make anything, and all we need to do is simulate it on the computer. The key problem that evolutionaries solve is learning structure: not just adjusting parameters, like backpropagation does, but creating the brain that those adjustments can then fine-tune. The evolutionaries’ master algorithm is genetic programming, which mates and evolves computer programs in the same way that nature mates and evolves organisms. Bayesians are concerned above all with uncertainty. All learned knowledge is uncertain, and learning itself is a form of uncertain inference. The problem then becomes how to deal with noisy, incomplete, and even contradictory information without falling apart. The solution is probabilistic inference, and the master algorithm is Bayes’ theorem and its derivates. Bayes’ theorem tells us how to incorporate new evidence into our beliefs, and probabilistic inference algorithms do that as efficiently as possible. For analogizers, the key to learning is recognizing similarities between situations and thereby inferring other similarities. If two patients have similar symptoms, perhaps they have the same disease. The key problem is judging how similar two things are. The analogizers’ master algorithm is the support vector machine, which figures out which experiences to remember and how to combine them to make new predictions.

Yet another study by the Brain Research Institute of the University of Zurich in 2011 exposed baby mice to stressful situations by separating them from their mothers. The abandoned mice experienced anxiety and depression—which, right, seems obvious. What was shocking was how this separation affected future generations of mice. When the traumatized mice had babies, and then when their babies had babies, the scientists never separated them from their parents. They led perfectly content, nurtured little mouse lives. But for three subsequent generations, the anxiety and depression persisted. There is real scientific evidence that the traumas we experience can be passed on to our children and even our grandchildren. DNA, of course, is the genetic code that determines the shape of our nose, our eye color, our likelihood to contract certain diseases. So when our body is making and remaking itself, every cell in our body actually “reads” our DNA and uses it as a blueprint for what to build. But not every cell reads the entire blueprint—the whole, long string of DNA. Inside each cell is both our DNA—or our genome—and the epigenome, a layer of chemical markers that sits on top of our DNA. The epigenome is like a SparkNotes for the cells—it flags which genes our cells really need to read. So the epigenome helps decide which genes actually get represented by our bodies. It turns certain genes on and other genes off. Both the genome and our epigenome are passed down generationally.

Take the famous slogan on the atheist bus in London … “There’s probably no God. Now stop worrying and enjoy your life.” … The word that offends against realism here is “enjoy.” I’m sorry—enjoy your life? Enjoy your life? I’m not making some kind of neo-puritan objection to enjoyment. Enjoyment is lovely. Enjoyment is great. The more enjoyment the better. But enjoyment is one emotion … Only sometimes, when you’re being lucky, will you stand in a relationship to what’s happening to you where you’ll gaze at it with warm, approving satisfaction. The rest of the time, you’ll be busy feeling hope, boredom, curiosity, anxiety, irritation, fear, joy, bewilderment, hate, tenderness, despair, relief, exhaustion … This really is a bizarre category error. But not necessarily an innocent one … The implication of the bus slogan is that enjoyment would be your natural state if you weren’t being “worried” by us believer … Take away the malignant threat of God-talk, and you would revert to continuous pleasure, under cloudless skies. What’s so wrong with this, apart from it being total bollocks? … Suppose, as the atheist bus goes by, that you are the fifty-something woman with the Tesco bags, trudging home to find out whether your dementing lover has smeared the walls of the flat with her own shit again. Yesterday when she did it, you hit her, and she mewled till her face was a mess of tears and mucus which you also had to clean up. The only thing that would ease the weight on your heart would be to tell the funniest, sharpest-tongued person you know about it: but that person no longer inhabits the creature who will meet you when you unlock the door. Respite care would help, but nothing will restore your sweetheart, your true love, your darling, your joy. Or suppose you’re that boy in the wheelchair, the one with the spasming corkscrew limbs and the funny-looking head. You’ve never been able to talk, but one of your hands has been enough under your control to tap out messages. Now the electrical storm in your nervous system is spreading there too, and your fingers tap more errors than readable words. Soon your narrow channel to the world will close altogether, and you’ll be left all alone in the hulk of your body. Research into the genetics of your disease may abolish it altogether in later generations, but it won’t rescue you. Or suppose you’re that skanky-looking woman in the doorway, the one with the rat’s nest of dreadlocks. Two days ago you skedaddled from rehab. The first couple of hits were great: your tolerance had gone right down, over two weeks of abstinence and square meals, and the rush of bliss was the way it used to be when you began. But now you’re back in the grind, and the news is trickling through you that you’ve fucked up big time. Always before you’ve had this story you tell yourself about getting clean, but now you see it isn’t true, now you know you haven’t the strength. Social services will be keeping your little boy. And in about half an hour you’ll be giving someone a blowjob for a fiver behind the bus station. Better drugs policy might help, but it won’t ease the need, and the shame over the need, and the need to wipe away the shame. So when the atheist bus comes by, and tells you that there’s probably no God so you should stop worrying and enjoy your life, the slogan is not just bitterly inappropriate in mood. What it means, if it’s true, is that anyone who isn’t enjoying themselves is entirely on their own. The three of you are, for instance; you’re all three locked in your unshareable situations, banged up for good in cells no other human being can enter. What the atheist bus says is: there’s no help coming … But let’s be clear about the emotional logic of the bus’s message. It amounts to a denial of hope or consolation, on any but the most chirpy, squeaky, bubble-gummy reading of the human situation. St Augustine called this kind of thing “cruel optimism” fifteen hundred years ago, and it’s still cruel.

No one likes to be told there’s something wrong with them, especially something like their genes, which they can’t change.” “You think there’s really something wrong with you?” “I guess so. It’s like a disease, right? They can see it in our genes. That’s not really up for debate, is it?” “I’m not saying your genes aren’t different,” I say. “I’m just saying that doesn’t mean one set is damaged and one set isn’t. The genes for blue eyes and brown eyes are different too, but are blue eyes ‘damaged’? It’s like they just arbitrarily decided that one kind of DNA was bad and the other was good.” “Based on the evidence that GD behavior was worse,” Christina points out. “Which could be caused by a lot of things,” I retort. “I don’t know why I’m arguing with you when I’d really like for you to be right,” Christina says, laughing. “But don’t you think a bunch of smart people like these Bureau scientists could figure out the cause of bad behavior?” “Sure,” I say. “But I think that no matter how smart, people usually see what they’re already looking for, that’s all.” “Maybe you’re biased too,” she says. “Because you have friends--and a boyfriend--with this genetic issue.” “Maybe.” I know I’m fumbling for an explanation, one I may not really believe, but I say it anyway: “I guess I don’t see a reason to believe in genetic damage. Will it make me treat other people better? No. The opposite, maybe.” And besides, I see what it’s doing to Tobias, how it’s making him doubt himself, and I don’t understand how anything good can possibly come from it. “You don’t believe things because they make your life better, you believe them because they’re true,” she points out. “But--” I speak slowly as I mull that over--“isn’t looking at the result of a belief a good way of evaluating if it’s true?” “Sounds like a Stiff way of thinking.” She pauses. “I guess my way is very Candor, though. God, we really can’t escape factions no matter where we go, can we?” I shrug. “Maybe it’s not so important to escape them.” Tobias walks into the dormitory, looking pale and exhausted, like he always does these days. His hair is pushed up on one side from lying on his pillow, and he’s still wearing what he wore yesterday. He’s been sleeping in his clothes since we came to the Bureau. Christina gets up. “Okay, I’m going to go. And leave you two...to all this space. Alone.” She gestures at all the empty beds, and then winks conspicuously at me as she walks out of the dormitory. Tobias smiles a little.

What do you think about it?” I say. “I don’t know. I guess it makes me angry.” She frowns. “No one likes to be told there’s something wrong with them, especially something like their genes, which they can’t change.” “You think there’s really something wrong with you?” “I guess so. It’s like a disease, right? They can see it in our genes. That’s not really up for debate, is it?” “I’m not saying your genes aren’t different,” I say. “I’m just saying that doesn’t mean one set is damaged and one set isn’t. The genes for blue eyes and brown eyes are different too, but are blue eyes ‘damaged’? It’s like they just arbitrarily decided that one kind of DNA was bad and the other was good.” “Based on the evidence that GD behavior was worse,” Christina points out. “Which could be caused by a lot of things,” I retort. “I don’t know why I’m arguing with you when I’d really like for you to be right,” Christina says, laughing. “But don’t you think a bunch of smart people like these Bureau scientists could figure out the cause of bad behavior?” “Sure,” I say. “But I think that no matter how smart, people usually see what they’re already looking for, that’s all.” “Maybe you’re biased too,” she says. “Because you have friends--and a boyfriend--with this genetic issue.” “Maybe.” I know I’m fumbling for an explanation, one I may not really believe, but I say it anyway: “I guess I don’t see a reason to believe in genetic damage. Will it make me treat other people better? No. The opposite, maybe.” And besides, I see what it’s doing to Tobias, how it’s making him doubt himself, and I don’t understand how anything good can possibly come from it. “You don’t believe things because they make your life better, you believe them because they’re true,” she points out. “But--” I speak slowly as I mull that over--“isn’t looking at the result of a belief a good way of evaluating if it’s true?” “Sounds like a Stiff way of thinking.” She pauses. “I guess my way is very Candor, though. God, we really can’t escape factions no matter where we go, can we?” I shrug. “Maybe it’s not so important to escape them.” Tobias walks into the dormitory, looking pale and exhausted, like he always does these days. His hair is pushed up on one side from lying on his pillow, and he’s still wearing what he wore yesterday. He’s been sleeping in his clothes since we came to the Bureau. Christina gets up. “Okay, I’m going to go. And leave you two...to all this space. Alone.” She gestures at all the empty beds, and then winks conspicuously at me as she walks out of the dormitory. Tobias smiles a little.

For abolitionists, who advocated the immediate emancipation of all slaves, and free-soilers, who simply opposed the spread of slavery into the western territories, the existence of such a group proved the destructive effect of slavery on social morals and human industry and the inordinate economic power of the planter elite. It also served as an implicit warning of the disastrous consequences of the spread of slavery into nonslaveholding regions and its debilitating effect on the work ethic of otherwise stalwart white farmers. For slave-holders, particularly those at the apex of southern society, the idleness of rural working-class whites justified the “peculiar institution” and made clear the need for a planter-led economic and social hierarchy. Planter D. R. Hundley wrote, for example, that “poor whites” were “the laziest two-legged animals that walk erect on the face of the earth . . . [and exhibited] a natural stupidity or dullness of intellect that almost surpasses belief.” To abolitionists and proslavery ideologues alike, therefore, southern poor whites utterly lacked industry, intelligence, social propriety, and honor, the essential ingredients for political and social equality and thus should not be trusted with political decision-making.7 Northern and southern middle- to upper-class commentators perceived this class of people as so utterly degraded that they challenged their assertion of “whiteness,” the one claim southern working-class whites had to political equality, “normative” status, and social superiority to free and enslaved blacks. Like Byrd and the author of “The Carolina Sand-Hillers,” journalists and travel writers repeatedly compared “poor whites” unfavorably to other supposedly inferior people of color, be they enslaved blacks, Indians, or even Mexican peasants. Through a variety of arguments, including genetic inferiority, excessive interbreeding with “nonwhites,” and environmental factors, such as the destructive influences of the southern climate, rampant disease, and a woefully inadequate diet, these writers asserted that “poor whites” were neither truly “white” nor clearly “nonwhite” but instead, a separate “‘Cracker’ race” in all ways so debased that they had no capacity for social advancement. This attitude is clear in an 1866 article from the Boston Daily Advertiser that proclaimed that this social class had reached depths of “[s]uch filthy poverty, such foul ignorance, such idiotic imbecility” that they could never be truly civilized. “[T]ime and effort will lead the negro up to intelligent manhood,” the author concluded, “but I almost doubt if it will be possible to ever lift this ‘white trash’ into respectability.”8 Contempt for working-class whites was almost as strong among African Americans as among middle-class and elite whites. Enslaved African Americans invented derogatory terms containing explicit versions of “whiteness” such as “(poor) white trash” and “poor buckra” (a derivative form of the West African word for “white man”). Although relations between slaves and non-elite southern whites were complex, many slaves deeply resented the role of poor whites as overseers and patrol riders and adopted their owners’ view that elite southern planters were socially and morally superior. Many also believed that blacks, enslaved and free, formed a middle layer of social respectability between the planter aristocracy at the top of the social system and the “poor whites” at the bottom. The construction of a “poor white” and “white trash” social and cultural category thus allowed black slaves to carve out a space of social superiority, as well as permitted the white planter elite to justify enormous economic and social inequality among whites in a supposedly democratic society.9