Dr Cortex Quotes

Much of what we do arises from automatic programming that bypasses conscious awareness and may even run contrary to our intentions, as Dr. Schwartz points out: The passive side of mental life, which is generated solely and completely by brain mechanisms, dominates the tone and tenor of our day-to-day, even our second-to-second experience. During the quotidian business of daily life, the brain does indeed operate very much as a machine does. Decisions that we may believe to be freely made can arise from unconscious emotional drives or subliminal beliefs. They can be dictated by events of which we have no recollection. The stronger a person’s automatic brain mechanisms and the weaker the parts of the brain that can impose conscious control, the less true freedom that person will be able to exercise in her life. In OCD, and in many other conditions, no matter how intelligent and well-meaning the individual, the malfunctioning brain circuitry may override rational judgment and intention. Almost any human being when overwhelmed by stress or powerful emotions, will act or react not from intention but from mechanisms that are set off deep in the brain, rather than being generated in the conscious and volitional segments of the cortex. When acting from a driven or triggered state, we are not free.

The infestation,” Dr. Pam says. She presses a button and zooms in on the front part of Chris’s brain. The pukish color intensifies, glowing neon bright. “This is the prefrontal cortex, the thinking part of the brain—the part that makes us human.

These computer simulations try only to duplicate the interactions between the cortex and the thalamus. Huge chunks of the brain are therefore missing. Dr. [Dharmendra] Modha understands the enormity of his project. His ambitious research has allowed him to estimate what it would take to create a working model of the entire human brain, and not just a portion or a pale version of it, complete with all parts of the neocortex and connections to the senses. He envisions using not just a single Blue Gene computer [with over a hundred thousand processors and terabytes of RAM] but thousands of them, which would fill up not just a room but an entire city block. The energy consumption would be so great that you would need a thousand-megawatt nuclear power plant to generate all the electricity. And then, to cool off this monstrous computer so it wouldn't melt, you would need to divert a river and send it through the computer circuits. It is remarkable that a gigantic, city-size computer is required to simulate a piece of human tissue that weighs three pounds, fits inside your skull, raises your body temperature by only a few degrees, uses twenty watts of power, and needs only a few hamburgers to keep it going.

You must have a callus on your cortex,” Dr. Tuttle said, clucking her tongue. “Not figuratively. Not literally, I mean. I’m saying, parenthetically,” she held up her hands and cupped them side by side to demonstrate the punctuation. “You’ve built up a tolerance, but it doesn’t mean the drugs are failing.” “You’re probably right,” I replied. “Not probably.

We walk through another part of the building. While we wait for an elevator, Dr. Kenyon unfolds a dinner-size napkin and holds it up in the air in front of his forehead. “This is about the size of your brain, spread out,” he says. “The part that matters. The cerebral cortex.” The 100 billion neurons there are also known as the brain’s gray matter. “And the human brain does things beyond anyone’s comprehension. Evolution created the smartest machine in this world.

2016, Dr. Naomi Eisenberger and fellow researchers reported that the experience of helping others lowers activity in the brain’s stress and threat centers, including the amygdala, dorsal anterior cingulate cortex, and anterior insula. At the same time, increased activity is seen in the parts of our brain associated with caregiving and rewards (our ventral striatum and septal area).10 This indicates that helping others reduces our stress even as it increases our sense of well-being, making

What’s more, AI researchers have begun to realize that emotions may be a key to consciousness. Neuroscientists like Dr. Antonio Damasio have found that when the link between the prefrontal lobe (which governs rational thought) and the emotional centers (e.g., the limbic system) is damaged, patients cannot make value judgments. They are paralyzed when making the simplest of decisions (what things to buy, when to set an appointment, which color pen to use) because everything has the same value to them. Hence, emotions are not a luxury; they are absolutely essential, and without them a robot will have difficulty determining what is important and what is not. So emotions, instead of being peripheral to the progress of artificial intelligence, are now assuming central importance. If a robot encounters a raging fire, it might rescue the computer files first, not the people, since its programming might say that valuable documents cannot be replaced but workers always can be. It is crucial that robots be programmed to distinguish between what is important and what is not, and emotions are shortcuts the brain uses to rapidly determine this. Robots would thus have to be programmed to have a value system—that human life is more important than material objects, that children should be rescued first in an emergency, that objects with a higher price are more valuable than objects with a lower price, etc. Since robots do not come equipped with values, a huge list of value judgments must be uploaded into them. The problem with emotions, however, is that they are sometimes irrational, while robots are mathematically precise. So silicon consciousness may differ from human consciousness in key ways. For example, humans have little control over emotions, since they happen so rapidly and because they originate in the limbic system, not the prefrontal cortex of the brain. Furthermore, our emotions are often biased.

But what separates human consciousness from the consciousness of animals? Humans are alone in the animal kingdom in understanding the concept of tomorrow. Unlike animals, we constantly ask ourselves “What if?” weeks, months, and even years into the future, so I believe that Level III consciousness creates a model of its place in the world and then simulates it into the future, by making rough predictions. We can summarize this as follows: Human consciousness is a specific form of consciousness that creates a model of the world and then simulates it in time, by evaluating the past to simulate the future. This requires mediating and evaluating many feedback loops in order to make a decision to achieve a goal. By the time we reach Level III consciousness, there are so many feedback loops that we need a CEO to sift through them in order to simulate the future and make a final decision. Accordingly, our brains differ from those of other animals, especially in the expanded prefrontal cortex, located just behind the forehead, which allows us to “see” into the future. Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest achievement of the human brain is its ability to imagine objects and episodes that do not exist in the realm of the real, and it is this ability that allows us to think about the future. As one philosopher noted, the human brain is an ‘anticipation machine,’ and ‘making the future’ is the most important thing it does.” Using brain scans, we can even propose a candidate for the precise area of the brain where simulation of the future takes place. Neurologist Michael Gazzaniga notes that “area 10 (the internal granular layer IV), in the lateral prefrontal cortex, is almost twice as large in humans as in apes. Area 10 is involved with memory and planning, cognitive flexibility, abstract thinking, initiating appropriate behavior, and inhibiting inappropriate behavior, learning rules, and picking out relevant information from what is perceived through the senses.” (For this book, we will refer to this area, in which decision making is concentrated, as the dorsolateral prefrontal cortex, although there is some overlap with other areas of the brain.)

The realization that there were electrical pathways connecting the brain to the body wasn’t systematically analyzed until the 1930s, when Dr. Wilder Penfield began working with epilepsy patients, who often suffered from debilitating convulsions and seizures that were potentially life-threatening. For them, the last option was to have brain surgery, which involved removing parts of the skull and exposing the brain. (Since the brain has no pain sensors, a person can be conscious during this entire procedure, so Dr. Penfield used only a local anesthetic during the operation.) Dr. Penfield noticed that when he stimulated certain parts of the cortex with an electrode, different parts of the body would respond. He suddenly realized that he could draw a rough one-to-one correspondence between specific regions of the cortex and the human body. His drawings were so accurate that they are still used today in almost unaltered form. They had an immediate impact on both the scientific community and the general public. In one diagram, you could see which region of the brain roughly controlled which function, and how important each function was. For example, because our hands and mouth are so vital for survival, a considerable amount of brain power is devoted to controlling them, while the sensors in our back hardly register at all. Furthermore, Penfield found that by stimulating parts of the temporal lobe, his patients suddenly relived long-forgotten memories in a crystal-clear fashion. He was shocked when a patient, in the middle of brain surgery, suddenly blurted out, “It was like … standing in the doorway at [my] high school.… I heard my mother talking on the phone, telling my aunt to come over that night.” Penfield realized that he was tapping into memories buried deep inside the brain. When he published his results in 1951, they created another transformation in our understanding of the brain.

A different approach was taken in 1972 by Dr. Walter Mischel, also of Stanford, who analyzed yet another characteristic among children: the ability to delay gratification. He pioneered the use of the “marshmallow test,” that is, would children prefer one marshmallow now, or the prospect of two marsh-mallows twenty minutes later? Six hundred children, aged four to six, participated in this experiment. When Mischel revisited the participants in 1988, he found that those who could delay gratification were more competent than those who could not. In 1990, another study showed a direct correlation between those who could delay gratification and SAT scores. And a study done in 2011 indicated that this characteristic continued throughout a person’s life. The results of these and other studies were eye-opening. The children who exhibited delayed gratification scored higher on almost every measure of success in life: higher-paying jobs, lower rates of drug addiction, higher test scores, higher educational attainment, better social integration, etc. But what was most intriguing was that brain scans of these individuals revealed a definite pattern. They showed a distinct difference in the way the prefrontal cortex interacted with the ventral striatum, a region involved in addiction. (This is not surprising, since the ventral striatum contains the nucleus accumbens, known as the “pleasure center.” So there seems to be a struggle here between the pleasure-seeking part of the brain and the rational part to control temptation, as we saw in Chapter 2.) This difference was no fluke. The result has been tested by many independent groups over the years, with nearly identical results. Other studies have also verified the difference in the frontal-striatal circuitry of the brain, which appears to govern delayed gratification. It seems that the one characteristic most closely correlated with success in life, which has persisted over the decades, is the ability to delay gratification. Although this is a gross simplification, what these brain scans show is that the connection between the prefrontal and parietal lobes seems to be important for mathematical and abstract thought, while the connection between the prefrontal and limbic system (involving the conscious control of our emotions and pleasure center) seems to be essential for success in life. Dr. Richard Davidson, a neuroscientist at the University of Wisconsin–Madison, concludes, “Your grades in school, your scores on the SAT, mean less for life success than your capacity to co-operate, your ability to regulate your emotions, your capacity to delay your gratification, and your capacity to focus your attention. Those skills are far more important—all the data indicate—for life success than your IQ or your grades.

Dr. Hobson (with Dr. Robert McCarley) made history by proposing the first serious challenge to Freud’s theory of dreams, called the “activation synthesis theory.” In 1977, they proposed the idea that dreams originate from random neural firings in the brain stem, which travel up to the cortex, which then tries to make sense of these random signals. The key to dreams lies in nodes found in the brain stem, the oldest part of the brain, which squirts out special chemicals, called adrenergics, that keep us alert. As we go to sleep, the brain stem activates another system, the cholinergic, which emits chemicals that put us in a dream state. As we dream, cholinergic neurons in the brain stem begin to fire, setting off erratic pulses of electrical energy called PGO (pontine-geniculate-occipital) waves. These waves travel up the brain stem into the visual cortex, stimulating it to create dreams. Cells in the visual cortex begin to resonate hundreds of times per second in an irregular fashion, which is perhaps responsible for the sometimes incoherent nature of dreams. This system also emits chemicals that decouple parts of the brain involved with reason and logic. The lack of checks coming from the prefrontal and orbitofrontal cortices, along with the brain becoming extremely sensitive to stray thoughts, may account for the bizarre, erratic nature of dreams. Studies have shown that it is possible to enter the cholinergic state without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims that meditation, worrying, or being placed in an isolation tank can induce this cholinergic state. Pilots and drivers facing the monotony of a blank windshield for many hours may also enter this state. In his research, he has found that schizophrenics have an unusually large number of cholinergic neurons in their brain stem, which may explain some of their hallucinations. To make his studies more efficient, Dr. Allan Hobson had his subjects put on a special nightcap that can automatically record data during a dream. One sensor connected to the nightcap registers the movements of a person’s head (because head movements usually occur when dreams end). Another sensor measures movements of the eyelids (because REM sleep causes eyelids to move). When his subjects wake up, they immediately record what they dreamed about, and the information from the nightcap is fed into a computer. In this way, Dr. Hobson has accumulated a vast amount of information about dreams. So what is the meaning of dreams? I asked him. He dismisses what he calls the “mystique of fortune-cookie dream interpretation.” He does not see any hidden message from the cosmos in dreams. Instead, he believes that after the PGO waves surge from the brain stem into the cortical areas, the cortex is trying to make sense of these erratic signals and winds up creating a narrative out of them: a dream.

As the subject watches the movies, the MRI machine creates a 3-D image of the blood flow within the brain. The MRI image looks like a vast collection of thirty thousand dots, or voxels. Each voxel represents a pinpoint of neural energy, and the color of the dot corresponds to the intensity of the signal and blood flow. Red dots represent points of large neural activity, while blue dots represent points of less activity. (The final image looks very much like thousands of Christmas lights in the shape of the brain. Immediately you can see that the brain is concentrating most of its mental energy in the visual cortex, which is located at the back of the brain, while watching these videos.) Gallant’s MRI machine is so powerful it can identify two to three hundred distinct regions of the brain and, on average, can take snapshots that have one hundred dots per region of the brain. (One goal for future generations of MRI technology is to provide an even sharper resolution by increasing the number of dots per region of the brain.) At first, this 3-D collection of colored dots looks like gibberish. But after years of research, Dr. Gallant and his colleagues have developed a mathematical formula that begins to find relationships between certain features of a picture (edges, textures, intensity, etc.) and the MRI voxels. For example, if you look at a boundary, you’ll notice it’s a region separating lighter and darker areas, and hence the edge generates a certain pattern of voxels. By having subject after subject view such a large library of movie clips, this mathematical formula is refined, allowing the computer to analyze how all sorts of images are converted into MRI voxels. Eventually the scientists were able to ascertain a direct correlation between certain MRI patterns of voxels and features within each picture. At this point, the subject is then shown another movie trailer. The computer analyzes the voxels generated during this viewing and re-creates a rough approximation of the original image. (The computer selects images from one hundred movie clips that most closely resemble the one that the subject just saw and then merges images to create a close approximation.) In this way, the computer is able to create a fuzzy video of the visual imagery going through your mind. Dr. Gallant’s mathematical formula is so versatile that it can take a collection of MRI voxels and convert it into a picture, or it can do the reverse, taking a picture and then converting it to MRI voxels. I had a chance to view the video created by Dr. Gallant’s group, and it was very impressive. Watching it was like viewing a movie with faces, animals, street scenes, and buildings through dark glasses. Although you could not see the details within each face or animal, you could clearly identify the kind of object you were seeing. Not only can this program decode what you are looking at, it can also decode imaginary images circulating in your head.

Recently, brain scans of schizophrenics taken while they were having auditory hallucinations have helped explain this ancient disorder. For example, when we silently talk to ourselves, certain parts of the brain light up on an MRI scan, especially in the temporal lobe (such as in Wernicke’s area). When a schizophrenic hears voices, the very same areas of the brain light up. The brain works hard to construct a consistent narrative, so schizophrenics try to make sense of these unauthorized voices, believing they originate from strange sources, such as Martians secretly beaming thoughts into their brains. Dr. Michael Sweeney of Ohio State writes, “Neurons wired for the sensation of sound fire on their own, like gas-soaked rags igniting spontaneously in a hot, dark garage. In the absence of sights and sounds in the surrounding environment, the schizophrenic’s brain creates a powerful illusion of reality.” Notably, these voices seem to be coming from a third party, who often gives the subject commands, which are mostly mundane but sometimes violent. Meanwhile, the simulation centers in the prefrontal cortex seem to be on automatic pilot, so in a way it’s as though the consciousness of a schizophrenic is running the same sort of simulations we all do, except they’re done without his permission. The person is literally talking to himself without his knowledge. HALLUCINATIONS The mind constantly generates hallucinations of its own, but for the most part they are easily controlled. We see images that don’t exist or hear spurious sounds, for example, so the anterior cingulate cortex is vital to distinguish the real from the manufactured. This part of the brain helps us distinguish between stimuli that are external and those that are internally generated by the mind itself. However, in schizophrenics, it is believed that this system is damaged, so that the person cannot distinguish real from imaginary voices. (The anterior cingulate cortex is vital because it lies in a strategic place, between the prefrontal cortex and the limbic system. The link between these two areas is one of the most important in the brain, since one area governs rational thinking, and the other emotions.) Hallucinations, to some extent, can be created on demand. Hallucinations occur naturally if you place someone in a pitch-black room, an isolation chamber, or a creepy environment with strange noises. These are examples of “our eyes playing tricks on us.” Actually, the brain is tricking itself, internally creating false images, trying to make sense of the world and identify threats. This effect is called “pareidolia.” Every time we look at clouds in the sky, we see images of animals, people, or our favorite cartoon characters. We have no choice. It is hardwired into our brains. In a sense, all images we see, both real and virtual, are hallucinations, because the brain is constantly creating false images to “fill in the gaps.” As we’ve seen, even real images are partly manufactured. But in the mentally ill, regions of the brain such as the anterior cingulate cortex are perhaps damaged, so the brain confuses reality and fantasy.

Another common form of mental illness is bipolar disorder, in which a person suffers from extreme bouts of wild, delusional optimism, followed by a crash and then periods of deep depression. Bipolar disorder also seems to run in families and, curiously, strikes frequently in artists; perhaps their great works of art were created during bursts of creativity and optimism. A list of creative people who were afflicted by bipolar disorder reads like a Who’s Who of Hollywood celebrities, musicians, artists, and writers. Although the drug lithium seems to control many of the symptoms of bipolar disorder, the causes are not entirely clear. One theory states that bipolar disorder may be caused by an imbalance between the left and right hemispheres. Dr. Michael Sweeney notes, “Brain scans have led researchers to generally assign negative emotions such as sadness to the right hemisphere and positive emotions such as joy to the left hemisphere. For at least a century, neuroscientists have noticed a link between damage to the brain’s left hemisphere and negative moods, including depression and uncontrollable crying. Damage to the right, however, has been associated with a broad array of positive emotions.” So the left hemisphere, which is analytical and controls language, tends to become manic if left to itself. The right hemisphere, on the contrary, is holistic and tends to check this mania. Dr. V. S. Ramachandran writes, “If left unchecked, the left hemisphere would likely render a person delusional or manic.… So it seems reasonable to postulate a ‘devil’s advocate’ in the right hemisphere that allows ‘you’ to adopt a detached, objective (allocentric) view of yourself.” If human consciousness involves simulating the future, it has to compute the outcomes of future events with certain probabilities. It needs, therefore, a delicate balance between optimism and pessimism to estimate the chances of success or failures for certain courses of action. But in some sense, depression is the price we pay for being able to simulate the future. Our consciousness has the ability to conjure up all sorts of horrific outcomes for the future, and is therefore aware of all the bad things that could happen, even if they are not realistic. It is hard to verify many of these theories, since brain scans of people who are clinically depressed indicate that many brain areas are affected. It is difficult to pinpoint the source of the problem, but among the clinically depressed, activity in the parietal and temporal lobes seems to be suppressed, perhaps indicating that the person is withdrawn from the outside world and living in their own internal world. In particular, the ventromedial cortex seems to play an important role. This area apparently creates the feeling that there is a sense of meaning and wholeness to the world, so that everything seems to have a purpose. Overactivity in this area can cause mania, in which people think they are omnipotent. Underactivity in this area is associated with depression and the feeling that life is pointless. So it is possible that a defect in this area may be responsible for some mood swings.

For instance, emotional memories are stored in the amygdala, but words are recorded in the temporal lobe. Meanwhile, colors and other visual information are collected in the occipital lobe, and the sense of touch and movement reside in the parietal lobe. So far, scientists have identified more than twenty categories of memories that are stored in different parts of the brain, including fruits and vegetables, plants, animals, body parts, colors, numbers, letters, nouns, verbs, proper names, faces, facial expressions, and various emotions and sounds. Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the brain stem, to the thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the hippocampus to form long-term memories. (illustration credit 5.1) A single memory—for instance, a walk in the park—involves information that is broken down and stored in various regions of the brain, but reliving just one aspect of the memory (e.g., the smell of freshly cut grass) can suddenly send the brain racing to pull the fragments together to form a cohesive recollection. The ultimate goal of memory research is, then, to figure out how these scattered fragments are somehow reassembled when we recall an experience. This is called the “binding problem,” and a solution could potentially explain many puzzling aspects of memory. For instance, Dr. Antonio Damasio has analyzed stroke patients who are incapable of identifying a single category, even though they are able to recall everything else. This is because the stroke has affected just one particular area of the brain, where that certain category was stored. The binding problem is further complicated because all our memories and experiences are highly personal. Memories might be customized for the individual, so that the categories of memories for one person may not correlate with the categories of memories for another. Wine tasters, for example, may have many categories for labeling subtle variations in taste, while physicists may have other categories for certain equations. Categories, after all, are by-products of experience, and different people may therefore have different categories. One novel solution to the binding problem uses the fact that there are electromagnetic vibrations oscillating across the entire brain at roughly forty cycles per second, which can be picked up by EEG scans. One fragment of memory might vibrate at a very precise frequency and stimulate another fragment of memory stored in a distant part of the brain. Previously it was thought that memories might be stored physically close to one another, but this new theory says that memories are not linked spatially but rather temporally, by vibrating in unison. If this theory holds up, it means that there are electromagnetic vibrations constantly flowing through the entire brain, linking up different regions and thereby re-creating entire memories. Hence the constant flow of information between the hippocampus, the prefrontal cortex, the thalamus, and the different cortices might not be entirely neural after all. Some of this flow may be in the form of resonance across different brain structures.

Dr. Small points out that this atmosphere of manic disruption makes my adrenal gland pump up production of cortisol and adrenaline. In the short run, these stress hormones boost energy levels and augment memory, but over time they actually impair cognition, lead to depression, and alter the neural circuitry in the hippocampus, amygdala, and prefrontal cortex—the brain regions that control mood and thought. Chronic and prolonged techno-brain burnout can even reshape the underlying brain structure. Techno-brain

Our brain processes incoming sensory input from the bottom up (see Figures 2 and 10), and if someone has a life with chaotic, uncontrollable, or extreme and prolonged stress, particularly early in life, they’re more likely to act before thinking. Their cortex is not as active, and reactivity in the lower areas of the brain becomes more dominant. It’s very difficult to meaningfully connect with or get through to someone who is not regulated. And it’s nearly impossible to reason with them. This is why telling someone who is dysregulated to “calm down” never works. Oprah: It just makes them angrier. Dr. Perry: Of course. When someone is very upset, words themselves are not very effective. The tone and rhythm of the voice probably has more impact than the actual words. Oprah: So you want to be present with them? Dr. Perry: Yes, it’s best if you can simply be present. If you do use words, it’s best to restate what they’re saying; this is called reflective listening.

Whatever the pertinent factor is,” Dr Caldwell says, her voice a quick, low murmur, “you’re its apogee. Do you know that? Genius-level mind and all that grey muck growing through your brain doesn’t affect it one bit. Ophiocordyceps should have eaten out your cortex until all that’s left is motor nerves and random backfires. But here you are.” She takes a step forward, and Melanie locksteps back away from her. “I’m

Because of the sequential processing of experience, this boy will always process “whiteness” in the lower part of his brain first. When he encounters a new white man, his original—and therefore default—association of white men and threat will cause a stress activation that can influence how he feels, thinks, and behaves. It’s like an evocative cue. The boy’s brain has already activated his fear response by the time any other information about the new white man can get to his cortex. In his cortex, he does have some autobiographical memory from seeing me, some stored information that “Dr. Perry is white, but he was okay.” But in the moment, with an activated fear response, he cannot efficiently access that information. He will look at this new white man and feel, “But this isn’t Dr. Perry.” Our first experiences create the filters through which all new experiences must pass.

In recent years, scientists have come to understand that consciously controlling your breath can have huge benefits on your overall system, primarily with regard to the regulation of your nervous system in relation to anxiety, depression, and restlessness. The vagal response is the stimulation of the vagus nerve, which runs down along the anterior portion of your spine from your brain to your internal organs. When the vagus nerve is stimulated, a signal is sent to the brain to reduce your blood pressure and calm your body and mind, reducing stress and helping to manage chronic illness, as healing can happen only in a more relaxed state of being. For example, if your amygdala, the nerve center at the lower-central part of your brain, is agitated, it triggers your sympathetic nervous system (SNS) and your fight-or-flight response. You may become anxious, fearful, reactive, or frozen. Once triggered, this response lasts at least 20 minutes, but you can often find yourself stuck in this state for much longer. According to Dr. Mladen Golubic, an internist at Cleveland Clinic’s Center for Integrative Medicine, when in this state, you take shallow chest breaths, sometimes halting the breath completely, extending the effects of your SNS response. By taking deeper and fuller breaths, especially by allowing the abdomen to relax and expand, the vagus nerve is stimulated, and calm can quickly be restored. This calming and stress-reducing response is called the parasympathetic nervous system (PNS) response, or vagal response. When your SNS is calmed, you have more access to the prefrontal cortex of your brain, boosting your ability to think clearly and rationalize. Dr. Golubic goes on to say, “The vagal response reduces stress. It reduces our heart rate and blood pressure.” This regulation of the nervous system is one of the primary benefits of a consistent pranayama practice.

Our brains differ as much as our bodies. Indeed, they may differ more. One part of the brain, the anterior commissure … varies seven-fold in area between one person and the next. Another part, the massa intermedia…, is not found at all in one in four people. The primary visual cortex can vary three-fold in area. Something called our amygdala (it is responsible for our fears and loves) can vary two-fold in volume—as can something called our hippocampus (involved in memory). Most surprisingly, our cerebral cortex varies in non-learning impaired people nearly two-fold in volume. Dr. John Robert Skoyles

As described by the Association for Contextual Behavioral Science, Acceptance and Commitment Therapy (ACT) is a form of empirically based psychological intervention that focuses on mindfulness. Mindfulness is the state of focusing on the present to remove oneself from feeling consumed by the emotion experienced in the moment. To properly observe yourself, begin by noticing where in your body you experience emotion. For example, think about a time when you felt really sad. You may have felt despair in your chest, or a sense of hollowness in your stomach. If you were angry, you may have felt a burning sensation in your arms. This occurs within everyone, in different variations. A study conducted by Carnegie Mellon University traced emotional responses in the brain to different activity signatures in the body through a functional magnetic resonance imaging (fMRI) scanner. If someone recalled a painful or traumatic memory, the prefrontal cortex and neocortex became less active, and their “reptilian brain” was activated. The former areas of the brain are responsible for conscious thought, spatial reasoning, and higher functions such as sensory perception. The latter is responsible for fight-or-flight responses. This means that the bodily responses caused by your emotions provide an opportunity for you to be mindful of them. Your emotions create sensations in your body that reflect your mind. Dr. Bruce Lipton, a developmental biologist who studies gene expression in relation to environmental factors, released a study on epigenetics that sheds light on this matter. It revealed that an individual’s body cannot heal when it is in its sympathetic state. The sympathetic nervous system, informally known as the fight-or-flight state, is triggered by certain emotional responses. This means that when we are consumed by emotion, an effective solution cannot be found until we shift our mind into reflecting on our emotions.

As described by the Association for Contextual Behavioral Science, Acceptance and Commitment Therapy (ACT) is a form of empirically based psychological intervention that focuses on mindfulness. Mindfulness is the state of focusing on the present to remove oneself from feeling consumed by the emotion experienced in the moment. To properly observe yourself, begin by noticing where in your body you experience emotion. For example, think about a time when you felt really sad. You may have felt despair in your chest, or a sense of hollowness in your stomach. If you were angry, you may have felt a burning sensation in your arms. This occurs within everyone, in different variations. A study conducted by Carnegie Mellon University traced emotional responses in the brain to different activity signatures in the body through a functional magnetic resonance imaging (fMRI) scanner. If someone recalled a painful or traumatic memory, the prefrontal cortex and neocortex became less active, and their “reptilian brain” was activated. The former areas of the brain are responsible for conscious thought, spatial reasoning, and higher functions such as sensory perception. The latter is responsible for fight-or-flight responses. This means that the bodily responses caused by your emotions provide an opportunity for you to be mindful of them. Your emotions create sensations in your body that reflect your mind. Dr. Bruce Lipton, a developmental biologist who studies gene expression in relation to environmental factors, released a study on epigenetics that sheds light on this matter. It revealed that an individual’s body cannot heal when it is in its sympathetic state. The sympathetic nervous system, informally known as the fight-or-flight state, is triggered by certain emotional responses. This means that when we are consumed by emotion, an effective solution cannot be found until we shift our mind into reflecting on our emotions. Let’s take a moment and test this theory together. Try to focus on what you’re feeling and where, and this will ground you in the present moment. By focusing on how you are responding, you essentially remove yourself from being consumed by your emotions in that moment. This brings you back into your sensory perception and moves the response in your brain back into the cortex and neocortex. This transition helps bring you back into a more logical state where emotions are not controlling your reactions.

Research actually shows that all childhood trauma, even bullying by our peers, can cause structural change in our amygdala,15 the part of our brain that detects threats in our environment, as well as in our prefrontal cortex,16 the region responsible for our “executive functions,” like our ability to plan, make decisions, and manage our social behavior. These structural changes as a result of childhood trauma create a state of hypervigilance whenever our nervous system is on alert. When this state becomes chronic or consistent over time it can manifest itself as social anxiety or complex post-traumatic stress disorder (C-PTSD), with related difficulties managing emotions, exercising inhibition, and, ultimately, having relationships.17 When our nervous system remains on high alert, we constantly scan our environment, engage in worst-case scenario thinking, and often become overwhelmed with racing thoughts while we anxiously wait for the other shoe to drop.

Chemically induced joy comes at a cost. That cost can be high. Very, very high. So high that you’re going to think twice after reading what science has to say about drug use. One study found that adolescents who smoke just a couple of joints of marijuana show changes in their brains. That’s not a couple of years of smoking or the decades that some adults rack up. It’s just two joints. A research team led by Dr. Gabriella Gobbi, a professor and psychiatrist at the McGill University Health Center in Montreal, discovered that teenagers using cannabis had a nearly 40% greater risk of depression and a 50% greater risk of suicidal ideation in adulthood. Dr. Gobbi stated that “given the large number of adolescents who smoke cannabis, the risk in the population becomes very big. About 7% of depression is probably linked to the use of cannabis in adolescence, which translates into more than 400,000 cases.” The research that revealed these startling numbers was not just a single study of adolescent marijuana use. It was a meta-analysis and review of 11 studies with a total of 23,317 teenage subjects followed through young adulthood. Further, Gobbi’s team only reviewed studies that provided information on depression in the subjects prior to their cannabis use. “We considered only studies that controlled for [preexisting] depression,” said Dr. Gobbi. “They were not depressed before using marijuana, so they probably weren’t using it to self-medicate.” Marijuana use preceded depression. The specific findings of Gobbi’s research include: The risk of depression associated with marijuana use in teens below age 18 is 1.4 times higher than among nonusers. The risk of suicidal thoughts is 1.5 times higher. The likelihood that teen marijuana users will attempt suicide is 3.46 times greater. In adults with prolonged marijuana use, the wiring of the brain degrades. Areas affected include the hippocampus (learning and memory), insula (compassion), and prefrontal cortex (executive functions). The authors of one study stated that “regular cannabis use is associated with gray matter volume reduction in the medial temporal cortex, temporal pole, parahippocampal gyrus, insula, and orbitofrontal cortex; these regions are rich in cannabinoid CB1 receptors and functionally associated with motivational, emotional, and affective processing. Furthermore, these changes correlate with the frequency of cannabis use . . . [while the] . . . age of onset of drug use also influences the magnitude of these changes.” A large number of studies show that cannabis use both increases anxiety and depression and leads to worse health. Key parts of your brain shrink more, based on how early you began smoking weed, and how often you smoke it. That’s a “high” price to pay.

People, on the other hand, defensively clung to their need to be right no matter how flawed their thinking. “Consciousness enabled by our particularly well-developed brains is what sets us apart,”he managed. He continued with a little more confidence. “Homo sapiens have a uniquely evolved neocortex, prefrontal cortex, and temporal lobes that make us capable of abstract thought, language, problem solving, and introspection.”“Our awareness makes us human then?”“No. It’s not simply a matter of passive awareness. Even slugs and plants have a level of sentience. It’s our ability to harness the power of our minds to gather knowledge, organize it into something relevant, and advance to a more evolved state. Our thoughts are the gateway. We think, therefore, we are.”“And how can we trust our thoughts?”“It’s a matter of intelligence and careful observation. You said yourself that ours is a universe of observable phenomena. The only barrier to apprehending the truth is our own unwillingness to see the world as it is instead of how we prefer it to be.”The professor’s lips nudged into a smile. “Perhaps. Well said, Mr. Hartt.”He turned toward the class. “Our time’s up today. For next class, please read chapters twenty through forty-five. And”—he glanced up at Austin—“be sure to arrive on time for the discussion.”Austin nodded as he stood. “Mr. Hartt, a word with you please?”Dr. Riley said, stuffing his papers into a leather briefcase

But we know from the experience of Tony Cicoria and many others that a hallucinatory journey to the bright light and beyond, a full-blown NDE, can occur in twenty or thirty seconds, even though it seems to last much longer. Subjectively, during such a crisis, the very concept of time may seem variable or meaningless. The one most plausible hypothesis in Dr. Alexander’s case, then, is that his NDE occurred not during his coma, but as he was surfacing from the coma and his cortex was returning to full function. It is curious that he does not allow this obvious and natural explanation but instead insists on a supernatural one.