Cell Biology Quotes

It is a well-documented fact that guys will not ask for directions. This is a biological thing. This is why it takes several million sperm cells... to locate a female egg, despite the fact that the egg is, relative to them, the size of Wisconsin.

The complexity of the simplest known type of cell is so great that it is impossible to accept that such an object could have been thrown together suddenly by some kind of freakish, vastly improbable, event. Such an occurrence would be indistinguishable from a miracle.

Being mortal is about the struggle to cope with the constraints of our biology, with the limits set by genes and cells and flesh and bone. Medical science has given us remarkable power to push against these limits, and the potential value of this power was a central reason I became a doctor. But again and again, I have seen the damage we in medicine do when we fail to acknowledge that such power is finite and always will be. We’ve been wrong about what our job is in medicine. We think our job is to ensure health and survival. But really it is larger than that. It is to enable well-being. And well-being is about the reasons one wishes to be alive. Those reasons matter not just at the end of life, or when debility comes, but all along the way. Whenever serious sickness or injury strikes and your body or mind breaks down, the vital questions are the same: What is your understanding of the situation and its potential outcomes? What are your fears and what are your hopes? What are the trade-offs you are willing to make and not willing to make? And what is the course of action that best serves this understanding?

Just like a single cell, the character of our lives is determined not by our genes but by our responses to the environmental signals that

I've always hated biology who cares how a cell divides, it just does

The latest research supports the notion that we have a natural ability to change the brain and body by thought alone, so that it looks biologically like some future event has already happened. Because you can make thought more real than anything else, you can change who you are from brain cell to gene, given the right understanding.

Just like a single cell, the character of our lives is determined not by our genes but by our responses to the environmental signals that propel life.

You may consider yourself an individual, but as a cell biologist, I can tell you that you are in truth a cooperative community of approximately fifty trillion single-celled citizens.

if half the cells inside of you are not you, doesn't that challenge the whole notion of me as a singular pronoun, let alone as the author of my fate?

In AP Bio, I learned that the cells in our body are replaced every seven years, which means that one day, I'll have a body full of cells that were never sick. But it also means that parts of me that knew and loved Sadie will disappear. I'll still remember loving her, but it'll be a different me who loved her. And maybe this is how we move on. We grow new cells to replace the grieving ones, diluting our pain until it loses potency. The percentage of my skin that touched hers will lessen until one day my lips won't be the same lips that kissed hers, and all I'll have are the memories. Memories of cottages in the woods, arranged in a half-moon. Of the tall metal tray return in the dining hall. Of the study tables in the library. The rock where we kissed. The sunken boat in Latham's lake, Sadie, snapping a photograph, laughing the lunch line, lying next to me at the movie night in her green dress, her voice on the phone, her apple-flavored lips on mine. And it's so unfair. All of it.

If a single cell, under appropriate conditions, becomes a man in the space of a few years, there can surely be no difficulty in understanding how, under appropriate conditions, a cell may, in the course of untold millions of years, give origin to the human race.

If we had better hearing, and could discern the descants of sea birds, the rhythmic tympani of schools of mollusks, or even the distant harmonics of midges hanging over meadows in the sun, the combined sound might lift us off our feet.

Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.

Once the cells in a biological machine stop working, it can never be started again. It goes into a cascade of decay, falling toward disorder and randomness. Except in the case of viruses. They can turn off and go dead. Then, if they come in contact with a living system, they switch on and multiply. (194)

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.

Okay, forget about the disrespect, facts don’t care about your feelings. It, turns out that every chromosome, every cell in Caitlyn Jenner’s body, is male, with the exception of some of his sperm cells. … It turns out that he still has all of his male appendages. How he feels on the inside is irrelevant to the question of his biological self.

The future is too interesting and dangerous to be entrusted to any predictable, reliable agency. We need all the fallibility we can get. Most of all, we need to preserve the absolute unpredictability and total improbability of our connected minds.

Your beliefs and thoughts are wired into your biology. They become your cells, tissues, and organs. There’s no supplement, no diet, no medicine, and no exercise regimen that can compare with the power of your thoughts and beliefs. That’s the very first place you need to look when anything goes wrong with your body.

In a reductionist view, understanding something complex requires breaking it down into its components; understand those parts, add them together, and you’ll understand the big picture. And in this reductionist world, to understand cells, organs, bodies, and behavior, the best constituent part to study is genes.

The oldest, easiest to swallow idea was that the earth was man's personal property, a combination of garden, zoo, bank vault, and energy source, placed at our disposal to be consumed, ornamented, or pulled apart as we wished.

The most essential prediction of Darwinism is that, given an astronomical number of chances, unintelligent processes can make seemingly-designed systems, ones of the complexity of those found in the cell. ID specifically denies this, predicting that in the absence of intelligent input no such systems would develop. So Darwinism and ID make clear, opposite predictions of what we should find when we examine genetic results from a stupendous number of organisms that are under relentless pressure from natural selection. The recent genetic results are a stringent test. The results: 1) Darwinism’s prediction is falsified; 2) Design’s prediction is confirmed.

When I started reading the literature of molecular biology, I was stunned by certain descriptions. Admittedly, I was on the lookout for anything unusual, as my investigation had led me to consider that DNA and its cellular machinery truly were an extremely sophisticated technology of cosmic origin. But as I pored over thousands of pages of biological texts, I discovered a world of science fiction that seemed to confirm my hypothesis. Proteins and enzymes were described as 'miniature robots,' ribosomes were 'molecular computers,' cells were 'factories,' DNA itself was a 'text,' a 'program,' a 'language,' or 'data.' One only had to do a literal reading of contemporary biology to reach shattering conclusions; yet most authors display a total lack of astonishment and seem to consider that life is merely 'a normal physiochemical phenomenon.

If biologists have ignored self-organization, it is not because self-ordering is not pervasive and profound. It is because we biologists have yet to understand how to think about systems governed simultaneously by two sources of order, Yet who seeing the snowflake, who seeing simple lipid molecules cast adrift in water forming themselves into cell-like hollow lipid vesicles, who seeing the potential for the crystallization of life in swarms of reacting molecules, who seeing the stunning order for free in networks linking tens upon tens of thousands of variables, can fail to entertain a central thought: if ever we are to attain a final theory in biology, we will surely, surely have to understand the commingling of self-organization and selection. We will have to see that we are the natural expressions of a deeper order. Ultimately, we will discover in our creation myth that we are expected after all.

Look at any randomly selected piece of your world. Encoded deep in the biology of every cell in every blade of grass, in every insect’s wing, in every bacterium cell, is the history of the third planet from the Sun in a Solar System making its way lethargically around a galaxy called the Milky Way. Its shape, form, function, colour, smell, taste, molecular structure, arrangement of atoms, sequence of bases, and possibilities for the future are all absolutely unique. There is nowhere else in the observable Universe where you will see precisely that little clump of emergent, living complexity. It is wonderful.

... Because the staging of human embryos is complex, owing to the continuous process of change during development, it is proposed that a new system of classification could be developed using the terms mentioned in the Qur'an and Sunnah. The proposed system is simple, comprehensive, and conforms with present embryological knowledge.287 (Dr. Keith L. Moore, Professor Emeritus, Department of Anatomy and Cell Biology, University of Toronto)

Willpower is more than just a metaphor; self-control is a finite resource. Frontal neurons are expensive cells, and expensive cells are vulnerable cells. Consistent

Nature abhors a long silence.

Why, you might ask, do the medical mysteries of the Covid-19 pandemic sit at the center of a book on cell biology? Because cell biology sits at the center of the medical mysteries.

Healing is a biological process, not an art. It is as much a function of the living organism as respiration, digestion, circulation, excretion, cell proliferation, or nerve activity. It is a ceaseless process, as constant as the turning of the earth on its axis. Man can neither duplicate nor imitate nor provide a substitute for the process. All schools of healing are frauds.

Individual humans are not super, but the organism of which we are all tiny cellular parts is most certainly that. The life-form that's so big we forget it's there, that turns minerals on its planet into tools to touch the infinite black gap between stars or probe the obliterating pressures at the bottom of the oceans. We are already part of a superbeing, a monster, a god, a living process that is so all encompassing that it is to an individual life what water is to a fish. We are cells in the body of a three-billion-year-old life-form whose roots are in the Precambrian oceans and whose genetic wiring extends through the living structures of everything on the planet, connecting everything that has ever lived in one immense nervous system.

about the biology of stress and recovery, stress seems to have an effect on the brain similar to that of vaccines on the immune system. In limited doses, it causes brain cells to overcompensate and thus gird themselves against future demands. Neuroscientists call this phenomenon stress inoculation.

God is an energy, rather than an anthropomorphic being, and God's language is biology. Red blood cells, the principle of magnetic attraction, neurological synapse: each is a miracle, and in each is the presence and flow of God.

Our brains contain one hundred billion nerve cells (neurons). Each neuron makes links with ten thousand other neurons to form an incredible three dimensional grid. This grid therefore contains a thousand trillion connections - that's 1,000,000,000,000,000 (a quadrillion). It's hard to imagine this, so let's visualise each connection as a disc that's 1mm thick. Stack up the quadrillion discs on top of each other and they will reach the sun (which is ninety-three million miles from the earth) and back, three times over.

Mackie kneaded his forehead. "Are you sure none of you want to call your parents?" "No, thank you." "Do you know who my father is?' "My stepmother's faking a pregnancy, and she needs her rest." Mackie wasn't touching that with a ten-foot pole. He turned to the last girl, the one who'd successfully picked the lock mere seconds after he'd arrived. "What about you?" he said hopefully. "My biological father literally threatened to kill me if I become inconvenient," the girl said, leaning back against the wall of the jail cell like she wasn't wearing a designer gown. "And if anyone finds out we were arrested, I'm out five hundred thousand dollars.

To grasp the reality of life as it has been revealed by molecular biology, we must magnify a cell a thousand million times until it is twenty kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would then see would be an object of unparalleled complexity and adaptive design. On the surface of the cell we would see millions of openings, like the port holes of a vast space ship, opening and closing to allow a continual stream of materials to flow in and out. If we were to enter one of these openings we would find ourselves in a world of supreme technology and bewildering complexity.

It seems that all eukaryotic cells either have, or once had (and then lost) mitochondria. In other words, possession of mitochondria is a sine qua non of the eukaryotic condition

When most of us hear the word cells, we think biology. I think penitentiary. (It's an occupational hazard.)

TP53 seems to encode the greater good, like a suicide pill in the mouth of a soldier that dissolves only when it detects evidence that he is about to mutiny.

I knew I was going to be a cellular biologist whose research would focus on scrutinizing every nuance of the cell's ultrastructure to gain insights into the secrets of cellular life.

My mitochondria comprise a very large proportion of me. I cannot do the calculation, but I suppose there is almost as much of them in sheer dry bulk as there is the rest of me. Looked at in this way, I could be taken for a very large, motile colony of respiring bacteria, operating a complex system of nuclei, microtubules, and neurons for the pleasure and sustenance of their families, and running, at the moment, a typewriter.

If it's true there's a beginning to the universe, as modern cosmologists now agree, then this implies a cause that transcends the universe. If the laws of physics are fine-tuned to permit life, as contemporary physicists are discovering, then perhaps there's a designer who fine-tuned them. If there's information in the cell, as molecular biology shows, then this suggests intelligent design. To get life going in the first place would have required biological information; the implications point beyond the material realm to a prior intelligent cause. -Stephen C Meyer, PHD

The almost biological certainty that the more often you checked your cell phone, the more likely you were to find that one wondrous message or notification that would improve your entire life.

The intensive studies of the Qur'an and Hadith in the last four years have revealed a system of classifying human embryos that is amazing since it was recorded in the seventh century A.D... the descriptions in the Qur'an cannot be based on scientific knowledge in the seventh century...288 (Dr. Keith L. Moore, Professor Emeritus, Department of Anatomy and Cell Biology, University of Toronto)

I shall argue that the distinction between a ‘living planet’ – one that is geologically active – and a living cell is only a matter of definition. There is no hard and fast dividing line. Geochemistry gives rise seamlessly to biochemistry. From this point of view, the fact that we can’t distinguish between geology and biology in these old rocks is fitting. Here is a living planet giving rise to life, and the two can’t be separated without splitting a continuum. Move

Throughout 150 years of the science of bacteriology, there is no evidence that one species of bacteria has changed into another... Since there is no evidence for species changes between the simplest forms of unicellular life, it is not surprising that there is no evidence for evolution from prokaryotic [i.e., bacterial] to eukaryotic [i.e., plant and animal] cells, let alone throughout the whole array of higher multicellular organisms.

it is illusion to think that there is anything fragile about the life of the earth; surely this is the toughest membrane imaginable in the universe, opaque to probability, impermeable to death. We are the delicate part, transient and vulnerable as cilia. Nor is it a new thing for Man to invent an existence that he imagines to be above the rest of life; this has been his most consistent intellectual exertion down the millennia. As illusion, it has never worked out to his satisfaction in the past, any more than it does today.

The uniformity of the earth's life, more astonishing than its diversity, is accountable by the high probability that we derived, originally, from some single cell, fertilized in a bolt of lightning as the earth cooled. It is from the progeny of this parent cell that we take our looks; we still share genes around, and the resemblance of the enzymes of grasses to those of whales is a family resemblance.

Some people say that we like wolves because they remind us of our dogs, but it is my assertion that we like our dogs because they actually remind us of our ancestral link with wolves, of the freedom that we still carry dormant, deep in our cells.

Originally, the atoms of carbon from which we’re made were floating in the air, part of a carbon dioxide molecule. The only way to recruit these carbon atoms for the molecules necessary to support life—the carbohydrates, amino acids, proteins, and lipids—is by means of photosynthesis. Using sunlight as a catalyst the green cells of plants combine carbon atoms taken from the air with water and elements drawn from the soil to form the simple organic compounds that stand at the base of every food chain. It is more than a figure of speech to say that plants create life out of thin air.

The longest-lasting cells in a human body live around seven years, so once they’re gone, once the longest surviving cells in your body have turned over and been replaced, and your skin and hair and blood cells have already turned over many thousands of times, you are biologically a different person. No physical cells of the old you remain. If that’s true, no cellular part of the me that loved Buck remains. But somehow, love remains.

a cell is a “programmable chip” whose behavior and genetic activity are primarily controlled by environmental signals, not genes.

THE GREATEST CHALLENGE today, not just in cell biology and ecology but in all of science, is the accurate and complete description of complex systems.

Out of the 7 billion people in the world, how many really understand quantum mechanics, cell biology or macroeconomics?

In the secret places of her thymus gland Louise is making too much of herself. Her faithful biology depends on regulation but the white T-cells have turned bandit. They don't obey the rules. They are swarming into the bloodstream, overturning the quiet order of spleen and intestine. In the lymph nodes they are swelling with pride. It used to be their job to keep her body safe from enemies on the outside. They were her immunity, her certainty against infection. Now they are the enemies on the inside. The security forces have rebelled. Louise is the victim of a coup. Will you let me crawl inside you, stand guard over you, trap them as they come at you? Why can't I dam their blind tide that filthies your blood? Why are there no lock gates on the portal vein? The inside of your body is innocent, nothing has taught it fear. Your artery canals trust their cargo, they don't check the shipments in the blood. You are full to overflowing but the keeper is asleep and there's murder going on inside. Who comes here? Let me hold up my lantern. It's only the blood; red cells carrying oxygen to the heart, thrombocytes making sure of proper clotting. The white cells, B and T types, just a few of them as always whistling as they go. The faithful body has made a mistake. This is no time to stamp the passports and look at the sky. Coming up behind are hundreds of them. Hundreds too many, armed to the teeth for a job that doesn't need doing. Not needed? With all that weaponry? Here they come, hurtling through the bloodstream trying to pick a fight. There's no-one to fight but you Louise. You're the foreign body now.

Suddenly I realized that a cell's life is controlled by the physical and energetic environment and not by its genes. Genes are simply molecular blueprints used in the construction of cells, tissues, and organs. The environment serves as a "contractor" who reads and engages those genetic blueprints and is ultimately responsible for the character of a cell's life. It is a single cell's "awareness" of the environment, not its genes, that sets into motion the mechanisms of life.

The living cell is the most complex system of its size known to mankind. Its host of specialized molecules, many found nowhere else but within living material, are themselves already enormously complex. They execute a dance of exquisite fidelity, orchestrated with breathtaking precision. Vastly more elaborate than the most complicated ballet, the dance of life encompasses countless molecular performers in synergetic coordination. Yet this is a dance with no sign of a choreographer. No intelligent supervisor, no mystic force, no conscious controlling agency swings the molecules into place at the right time, chooses the appropriate players, closes the links, uncouples the partners, moves them on. The dance of life is spontaneous, self-sustaining, and self-creating.

And so we have come full circle, from the discovery that consciousness contains the whole of objective reality—the entire history of biological life on the planet, the world's religions and mythologies, and the dynamics of both blood cells and stars—to the discovery that the material universe can also contain within its warp and weft the innermost processes of consciousness. Such is the nature of the deep connectivity that exists between all things in a holographic universe. In the next chapter we will explore how this connectivity, as well as other aspects of the holographic idea, affect our current understanding of health.

school you may have learned the basic components of a cell: the nucleus that contains genetic material, the energy-producing mitochondria, the protective membrane at the outside rim, and the cytoplasm in between.

Consider this: the human genome codes for about 1,500 different TFs, contains 4,000,000 TF-binding sites, and the average cell uses about 200,000 such sites to generate its distinctive gene-expression profile.5 This is boggling.

An irrefutable proof that such single-celled primaeval animals really existed as the direct ancestors of Man, is furnished according to the fundamental law of biogeny by the fact that the human egg is nothing more than a simple cell.

In fact, certain foods and lifestyle practices can unlock immense self-regenerative energetic resources within your cells, optimizing DNA expression and making them more important in affecting your health than any other single factor.

A solitary ant, afield, cannot be considered to have much of anything on his mind; indeed, with only a few neurons strung together by fibers, he can’t be imagined to have a mind at all, much less a thought. He is more like a ganglion on legs. Four ants together, or ten, encircling a dead moth on a path, begin to look more like an idea. They fumble and shove, gradually moving the food toward the Hill, but as though by blind chance. It is only when you watch the dense mass of thousands of ants, crowded together around the Hill, blackening the ground, that you begin to see the whole beast, and now you observe it thinking, planning, calculating. It is an intelligence, a kind of live computer, with crawling bits for its wits.

The principal result of my investigation is that a uniform developmental principle controls the individual elementary units of all organisms, analogous to the finding that crystals are formed by the same laws in spite of the diversity of their forms.

When your grandmother was five months pregnant with your mother, the precursor cell of the egg you developed from was already present in your mother’s ovaries. This means that before your mother was even born, your mother, your grandmother, and the earliest traces of you were all in the same body—three generations sharing the same biological environment.1 This isn’t a new idea: embryology textbooks have told us as much for more than a century. Your inception can be similarly traced in your paternal line. The precursor cells of the sperm you developed from were present in your father when he was a fetus in his mother’s womb.

We should not be too quick to dismiss our own [ocular] arrangement. As so often in biology, the situation is more complex.....we have the advantage that our own light-sensitive cells are embedded directly in their support cells (the retinal pigment epithelium) with an excellent blood supply immediately underneath. Such an arrangement supports the continuous turnover of photosensitive pigments. The human retina consumes even more oxygen than the brain, per gram, making it the most energetic organ in the body.

The cell, this elementary keystone of living nature, is far from being a peculiar chemical giant molecule or even a living protein and as such is not likely to fall prey to the field of an advanced chemistry. The cell is itself an organism, constituted of many small units of life.

Well, biology is not only about genes and environment, but also cells and the constraints of their physical structure, which we shall see have little to do with either genes or environment directly. The predictions that arise from these disparate world views are strikingly different.

Stress and glucocorticoids have inverted-U effects here as well. Moderate, transient stress (or exposure to the equivalent glucocorticoid levels) increases spine number in the hippocampus; sustained stress or glucocor-ticoid exposure does the opposite.7 Moreover, major depression or anxiety—two disorders associated with elevated glucocorticoid levels—can reduce hippocampal dendrite and spine number. This arises from decreased levels of that key growth factor mentioned earlier this chapter, BDNF. Sustained stress and glucocorticoids also cause dendritic retraction and synapse loss, lower levels of NCAM (a “neural cell adhesion molecule” that stabilizes synapses), and less glutamate release in the frontal cortex.

Only the neurosurgeon dares to improve upon five billion years of evolution in a few hours. The human brain. A trillion nerve cells storing electrical patterns more numerous than the water molecules of the world’s oceans. The soul’s tapestry lies woven in the brain’s nerve threads. Delicate, inviolate, the brain floats serenely in a bone vault like the crown jewel of biology. What motivated the vast leap in intellectual horsepower between chimp and man? Between tree dweller and moon walker? Is the brain a gift from God, or simply the jackpot of a trillion rolls of DNA dice?

Bill read in a biology book about how cells replace themselves over the years; how bodies died and were remade out of interchangeable pieces. It depressed him how foreign his younger self looked to him now, how his body had stolen the identity of this happy dead kid, and with his own life, had made a complete mess of it

Elevated blood sugar stirs up inflammation in the bloodstream, as excess sugar can be toxic if it’s not swept up and used by cells. It also triggers a reaction called glycation—the biological process by which sugar binds to proteins and certain fats, resulting in deformed molecules that don’t function well. These sugar proteins are technically called advanced glycation end products (AGEs). The body does not recognize AGEs as normal, so they set off inflammatory reactions. In the brain, sugar molecules and brain proteins combine to produce lethal new structures that contribute to the degeneration of the brain and its functioning. The relationship between poor blood sugar control and Alzheimer’s disease in particular is so strong that researchers are now calling Alzheimer’s disease type-3 diabetes.14

fields and land to one side and the other. It finds its way into wells and is drawn up to launder petticoats and be boiled for tea. It is sucked into root membranes, travels up cell by cell to the surface, is held in the leaves of watercress that find themselves in the soup bowls and on the cheeseboards of the county’s diners. From teapot or soup dish, it passes into mouths, irrigates complex internal biological networks that are worlds in themselves, before returning eventually to the earth via a chamber pot. Elsewhere the river water clings to the leaves of the willows that droop to touch its surface and then, when the sun comes up, a droplet appears to vanish into the air, where it travels invisibly and might join a cloud, a vast floating lake, until it falls again as rain. This is the unmappable journey of the Thames.

A tissue is evidently an enduring thing. It's functional and structural conditions become modified from moment to moment. Time is really the fourth dimension of living organisms. It enters as part into the constitution of a tissue. Cell colonies, or organs, are events which progressively unfold themselves. They must be studied like history.

Do you know what a fate map is in biology? It’s a map of which cells in an embryo should develop into which specific adult tissues. But what they should develop into isn’t necessarily what they actually do develop into. They can be manipulated, or change on their own, and end up as something completely different from what they were fated for.

This, rather, is the story of how the concept of the cell, and our comprehension of cellular physiology, altered medicine, science, biology, social structures, and culture.

If intelligent design was true the human body would make its own food and alcohol would kill fat cells instead of brain cells.

I have no more sense of what goes on in the mind of mankind than I have for the mind of an ant. Come to think of it, this might be a good place to start.

Now all I know about her is my memories of her. And these memories fade further and further into the distance like displaced cells. Was it all biology?

You could make iPS cells by introducing just four genes into a differentiated cell.

All of today's DNA, strung through all the cells of the earth, is simply an extension and elaboration of [the] first molecule.

The cause of nutrition and growth resides not in the organism as a whole but in the separate elementary parts—the cells.

Happiness is a drug. It creates a biological change in the brain cells that inhibits negative feelings. Happiness boosts energy and increases energy in others.

Arriving at cell theory has been considered even more important to biology than Darwin’s theory of evolution,

Every cell dreams of becoming two cells”. Cells just become populations

The genome constitutes only about 1 percent of the dry weight of a cell, which means that only a tiny proportion of the cell is actually synthetic.

It’s incredible to think that mammalian cells carry about 20,000 genes, and yet it only takes four to turn a fully differentiated cell into something that is pluripotent.

My instinct, of course, is to imagine us as one of many planets racing its evolution against its sun--merely one in the galactic Darwinian pursuit. But maybe we're not. Maybe all this talk of the inevitability of aliens is garbage and we're miraculously, beautifully alone in our biological success. What if we're winning? What if we're actually the most evolved intelligence in all this big bang chaos? What if other planets have bacteria and single-celled genotypes but nothing more? The precedent is all the more pressing. Humans alone could be winning the race against our giant gas time bomb and running with the universal Olympic torch. What an honor. What a responsibility. What a gift we have been given to be born in an atmosphere with oxygen and carbon dioxide and millions of years and phenotypes cheering us on with recycles of energy. The thing is, I think we can make it. I think we can shove ourselves into spaceships before things get too cold. I only hope we don't fuck things up before that. Because millions of years is a long time and I don't want to let the universe down.

Darwin, with his Origin of Species, his theories about Natural Selection, the Survival of the Fittest, and the influence of environment, shed a flood of light upon the great problems of plant and animal life. These things had been guessed, prophesied, asserted, hinted by many others, but Darwin, with infinite patience, with perfect care and candor, found the facts, fulfilled the prophecies, and demonstrated the truth of the guesses, hints and assertions. He was, in my judgment, the keenest observer, the best judge of the meaning and value of a fact, the greatest Naturalist the world has produced. The theological view began to look small and mean. Spencer gave his theory of evolution and sustained it by countless facts. He stood at a great height, and with the eyes of a philosopher, a profound thinker, surveyed the world. He has influenced the thought of the wisest. Theology looked more absurd than ever. Huxley entered the lists for Darwin. No man ever had a sharper sword -- a better shield. He challenged the world. The great theologians and the small scientists -- those who had more courage than sense, accepted the challenge. Their poor bodies were carried away by their friends. Huxley had intelligence, industry, genius, and the courage to express his thought. He was absolutely loyal to what he thought was truth. Without prejudice and without fear, he followed the footsteps of life from the lowest to the highest forms. Theology looked smaller still. Haeckel began at the simplest cell, went from change to change -- from form to form -- followed the line of development, the path of life, until he reached the human race. It was all natural. There had been no interference from without. I read the works of these great men -- of many others – and became convinced that they were right, and that all the theologians -- all the believers in "special creation" were absolutely wrong. The Garden of Eden faded away, Adam and Eve fell back to dust, the snake crawled into the grass, and Jehovah became a miserable myth.

The fact is that hundreds of trillions of microbial “invaders,” mostly in our gut, are absolutely necessary for our survival, and there are ten times more of them than cells in the human body. Because the body cannot survive without its microbes (collectively called the “microbiome”), they are the functional equivalent of any of our other vital organ systems. In (belated) recognition of the importance of the microbiome, humans and most other organisms are now properly defined as superorganisms (complex organisms composed of many smaller organisms). (Saey

Biology is run by intricate cellular mechanisms. Cellular mechanisms are run by Nature. Thus, the more we attempt to understand Nature, the more we get closer to our existential properties.

Nanotechnology will enable the design of nanobots: robots designed at the molecular level, measured in microns (millionths of a meter), such as “respirocytes” (mechanical red-blood cells).33 Nanobots will have myriad roles within the human body, including reversing human aging (to the extent that this task will not already have been completed through biotechnology, such as genetic engineering).

count of white blood cells, or leukocytes. Manufactured in the bone marrow, these cells are the foundation of the body’s immune system and among the most reliable biological markers of the effects of ARS.

it was widely known that the gene-carrying chromosomes within cells contained DNA, but most biologists thought that DNA was too simple and boring a molecule to be responsible for such a complex phenomenon as heredity.

In AP Bio, I learned that the cells in our body are replaced every seven years, which means that one day I'll have a body full of cells that were never sick. But it also means that the parts of me that knew and loved Sadie will disappear. I'll still remember loving her, but it'll be a different me who loved her. And maybe this is how we move on. We grow new cells to replace the grieving ones, diluting our pain until it loses potency.

over 80 percent of noncoding DNA is involved with regulating the production and assembly of gene-encoded proteins. A major discovery also found that “dark” DNA contains mechanisms by which environmental information can be used to modify the readout of protein-encoding genes. It turns out that dark DNA uses epigenetic mechanisms that enable a human cell with 19,000 gene blueprints to code for over a hundred thousand different protein molecules!

If this is hard to understand from a map, the rest is harder. For one thing, the river that flows ever onwards is also seeping sideways, irrigating the fields and land to one side and the other. It finds its way into wells and is drawn up to launder petticoats and be boiled for tea. It is sucked into root membranes, travels up cell by cell to the surface, is held in the leaves of watercress that find themselves in the soup bowls and on the cheeseboards of the county’s diners. From teapot or soup dish, it passes into mouths, irrigates complex internal biological networks that are worlds in themselves, before returning eventually to the earth via a chamber pot. Elsewhere the river water clings to the leaves of the willows that droop to touch its surface and then, when the sun comes up, a droplet appears to vanish into the air, where it travels invisibly and might join a cloud, a vast floating lake, until it falls again as rain. This is the unmappable journey of the Thames. And there is more: what we see on a map is only the half of it. A river no more begins at its source than a story begins with the first page.

Remarkably, the fetal brain generates far more neurons than are found in the adult. Why? During late fetal development, there is a dramatic competition in much of the brain, with winning neurons being the ones that migrate to the correct location and maximize synaptic connections to other neurons. And neurons that don’t make the grade? They undergo “programmed cell death”—genes are activated that cause them to shrivel and die, their materials then recycled.

The evolutionists, piercing beneath the show of momentary stability, discovered, hidden in rudimentary organs, the discarded rubbish of the past. They detected the reptile under the lifted feathers of the bird, the lost terrestrial limbs dwindling beneath the blubber of the giant cetaceans. They saw life rushing outward from an unknown center, just as today the astronomer senses the galaxies fleeing into the infinity of darkness. As the spinning galactic clouds hurl stars and worlds across the night, so life, equally impelled by the centrifugal powers lurking in the germ cell, scatters the splintered radiance of consciousness and sends it prowling and contending through the thickets of the world.

Logically, when the amygdala wants to mobilize a behavior—say, fleeing—it talks to the frontal cortex, seeking its executive approval. But if sufficiently aroused, the amygdala talks directly to subcortical, reflexive motor pathways. Again, there’s a trade-off—increased speed by bypassing the cortex, but decreased accuracy. Thus the input shortcut may prompt you to see the cell phone as a gun. And the output shortcut may prompt you to pull a trigger before you consciously mean to.

Logically, when the amygdala wants to mobilize a behavior—say, fleeing—it talks to the frontal cortex, seeking its executive approval. But if sufficiently aroused, the amygdala talks directly to subcortical, reflexive motor pathways. Again, there’s a trade-off—increased speed by by-passing the cortex, but decreased accuracy. Thus the input shortcut may prompt you to see the cell phone as a gun. And the output shortcut may prompt you to pull a trigger before you consciously mean to.

Buchner proposed that fermentation was carried out by biological catalysts that he named enzymes (from the Greek en zyme, meaning in yeast). He concluded that living cells are chemical factories, in which enzymes manufacture the various products.

Another clue to the cause of aging might be telomerase, which helps to regulate our biological clock. Every time a cell divides, the tips of the chromosomes, called telomeres, get a bit shorter. Eventually, after approximately fifty to sixty divisions, the telomeres become so short that they disappear and the chromosome begins to fall apart, so the cell enters a state of senescence and no longer functions correctly. Thus there is a limit to how many times a cell can divide, called the Hayflick limit.

She’d spent so much of her life seeing the world as black-and-white, separating right from wrong as confidently as she sorted plant cells from animal cells during a biology exam. But the past year had been a brutal crash course in moral relativity. Clarke

Making energy creates waste, like exhaust from a car. That’s the byproduct of running the engine. Your cells work the same way, but this biological exhaust comes in the form of what are called free radicals, which are chemicals that can damage your cells.

Morgan had discovered an important modification to Mendel's laws. Genes did not travel separately; instead, they moved in packs. Packets of information were themselves packaged-into chromosomes, and ultimately in cells. But the discovery had a more important consequence: conceptually, Morgan had not just linked genes; he had linked two disciplines-cell biology and genetics. The gene was not a "purely theoretical unit." It was a material thing that lived in a particular location, and a particular form, within a cell.

[W]hen food is placed at the start and end points of the maze, the slime mold withdraws from the dead-end corridors and shrinks its body to a tube spanning the shortest path between food sources. The single-celled slime solves the maze in this way each time it is tested.”23 Toshiyuki Nakagaki, the researcher conducting the study, commented that Even for humans it is not easy to solve a maze. But the plasmodium of true slime mold, an amoeba-like organism, has shown an amazing ability to do so. This implies that an algorithm and a high computing capacity are included in the unicellular organism.24 This capacity for mathematical differentiation and computation is wide spread. All self-organized biological systems possess it. One of the more amazing examples is the Clark’s Nutcracker.

So one way of looking at our trillion-celled bodies is that they are protein machines, although, as you know, I think we are more than machines! It sounds simple, but it isn’t. For one thing, it takes over 100,000 different types of proteins to run our bodies. Let

Synthetic biology56 is built around the idea that DNA is essentially software—nothing more than a four-letter code arranged in a specific order. Much like with computers, the code drives the machine. In biology, the order of the code governs the cell’s manufacturing processes, instructing it to make specific proteins and such. But, as with all software, DNA can be reprogrammed. Nature’s original code can be swapped out for new, human-written code. We can co-opt the machinery of life, telling it to produce—well, whatever we can think of.

How does this work? Rodents produce pheromonal odors with individual signatures, derived from genes called the major histocompatibility complex (MHC). This is a super variable gene cluster that produces unique proteins that form a signature for an individual. This was first studied by immunologists. What does the immune system do? It differentiates between you and invaders—“self” and “nonself”—and attacks the latter. All your cells carry your unique MHC-derived protein, and surveillance immune cells attack any cell lacking this protein password.

The reality is that most of us grow up strapped in an educational system that favors obedience over independent thinking. We’re rewarded for trusting authority, and punished for challenging it. We focus on memorizing the stuff other people came up with—formulas in math, grammar rules in English, theories in physics, cell functions in biology—rather than grasping the logic behind our most important breakthroughs and tracing the footsteps of their discovery. We answer test questions with what we think our teacher wants to hear. We chase grades instead of knowledge. And worst of all, we leave the classroom woefully unequipped with the thinking skills that matter most: how to balance open-mindedness with skepticism, how to identify bias, and how to challenge assumptions—including our own—in a way that’s truly objective.

For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.

Were it not for the melanin in our skin, myoglobin in our muscles and haemoglobin in our blood, we would be the colour of mitochondria. And, if this were so, we would change colour when we exercised or ran out of breath, so that you could tell how energized someone was from his or her colour.

You gently leaned over her to kiss her forehead and pulled the blankets around her shoulders. No father can adequately articulate the experience of watching his sleeping child—it must be lived. Now, imagine you are walking out of her room. Could you turn around and look at her and believe that the sum of her existence rests in a mass of cells? Certainly not. But this is exactly how a rank secularist is obliged to view his daughter. She is nothing more than a genetic product of his and her mother’s DNA. The puffing of air through her tiny chest keeps her alive. Your time with her is precious, meaningful, but purely a biological phenomenon. Her thoughts and feelings can be traced to neuronal firing in her brain. One day you will die and she will die and that will be that. Life began through the splitting and rejoining of DNA and when they stopped functioning, she did too.

Your cells are a country of ten thousand trillion citizens, each devoted in some intensively specific way to your overall well-being. There isn’t a thing they don’t do for you. They let you feel pleasure and form thoughts. They enable you to stand and stretch and caper. When you eat, they extract the nutrients, distribute the energy, and carry off the wastes - all those things you learned about in junior high school biology - but they also remember to make you hungry in the first place and reward you with a feeling of well-being afterward so that you won’t forget to eat again. They keep your hair growing, your ears waxed, your brain quietly purring. They manage every corner of your being. They will jump to your defence the instant you are threatened. They will unhesitatingly die for you - billions of them do so daily. And not once in all your years have you thanked even one of them.

Today we know that in fact our brains are constantly being reshaped, with nerve cells routinely breaking off old connections and creating new ones. To be more precise, the sensitivity of the receptors in the synapses changes. If we allow ourselves to be overwhelmed by a new cultural phenomenon such as the torrent of news, it reshapes our mental apparatus. It literally brainwashes us. This adaptation takes place on the level of biology. News rewires us. As a consequence, our brain works differently even when we’re not actively reading the news. Differently, and – you’ve guessed it – not for the better.

almost every living cell there was already a functioning computer with a huge memory? A mammalian cell had a DNA complement of several billion base pairs, each acting as a piece of information. What was reproduction, after all, but a computerized biological process of enormous complexity and reliability?

When scientists underestimate complexity, they fall prey to the perils of unintended consequences. The parables of such scientific overreach are well-known: foreign animals, introduced to control pests, become pests in their own right; the raising of smokestacks, meant to alleviate urban pollution, releases particulate effluents higher in the air and exacerbates pollution; stimulating blood formation, meant to prevent heart attacks, thickens the blood and results in an increased risk of blood clots in the heart. But when nonscientists overestimate [italicized, sic] complexity- 'No one can possibly crack this [italicized, sic] code" - they fall into the trap of unanticipated consequences. In the early 1950s , a common trope among some biologists was that the genetic code would be so context dependent- so utterly determined by a particular cell in a particular organism and so horribly convoluted- that deciphering it would be impossible. The truth turned out to be quite the opposite: just one molecule carries the code, and just one code pervades the biological world. If we know the code, we can intentionally alter it in organisms, and ultimately in humans. Similarly, in the 1960s, many doubted that gene-cloning technologies could so easily shuttle genes between species. by 1980, making a mammalian protein in a bacterial cell, or a bacterial protein in a mammalian cell, was not just feasible, it was in Berg's words, rather "ridiculously simple." Species were specious. "Being natural" was often "just a pose.

Minnows and catfish can recognize each member of their own species by his particular, person-specific odor. It is hard to imagine a solitary, independent, existentialist minnow, recognizable for himself alone; minnows in a school behave like interchangeable, identical parts of an organism. But there it is.

There is a significant hereditary contribution to ADD but I do not believe any genetic factor is decisive in the emergence of ADD traits in any child. Genes are codes for the synthesis of the proteins that give a particular cell its characteristic structure and function. They are, as it were, alive and dynamic architectural and mechanical plans. Whether the plan becomes realized depends on far more than the gene itself. It is determined, for the most part, by the environment. To put it differently, genes carry potentials inherent in the cells of a given organism. Which of multiple potentials become expressed biologically is a question of life circumstances. Were we to adopt the medical model — only temporarily, for the sake of argument — a genetic explanation by itself would still be unsuitable. Medical conditions for which genetic inheritance are fully or even mostly responsible, such as muscular dystrophy, are rare. “Few diseases are purely genetic,” says Michael Hayden, a geneticist at the University of British Columbia and a world-renowned researcher into Huntington’s disease. “The most we can say is that some diseases are strongly genetic.” Huntington’s is a fatal degeneration of the nervous system based on a single gene that, if inherited, will almost invariably cause the disease. But not always. Dr. Hayden mentions cases of persons with the gene who live into ripe old age without any signs of the disease itself. “Even in Huntington’s, there must be some protective factor in the environment,” Dr. Hayden says.

Our prototypical behavior has occurred. How was it influenced by events when the egg and sperm that formed that person joined, creating their genome—the chromosomes, the sequences of DNA—destined to be duplicated in every cell in that future person’s body? What role did those genes play in causing that behavior?

The brain is the last and grandest biological frontier, the most complex thing we have yet discovered in our universe. It contains hundreds of billions of cells interlinked through trillions of connections. The brain boggles the mind.”   —James D. Watson, Nobel Laureate and co-discoverer of the structure of DNA.

The case I’ve presented in this book suggests that humans are undergoing what biologists call a major transition. Such transitions occur when less complex forms of life combine in some way to give rise to more complex forms. Examples include the transition from independently replicating molecules to replicating packages called chromosomes or, the transition from different kinds of simple cells to more complex cells in which these once-distinct simple cell types came to perform critical functions and become entirely mutually interdependent, such as the nucleus and mitochondria in our own cells. Our species’ dependence on cumulative culture for survival, on living in cooperative groups, on alloparenting and a division of labor and information, and on our communicative repertoires mean that humans have begun to satisfy all the requirements for a major biological transition. Thus, we are literally the beginnings of a new kind of animal.1 By contrast, the wrong way to understand humans is to think that we are just a really smart, though somewhat less hairy, chimpanzee. This view is surprisingly common. Understanding how this major transition is occurring alters how we think about the origins of our species, about the reasons for our immense ecological success, and about the uniqueness of our place in nature. The insights generated alter our understandings of intelligence, faith, innovation, intergroup competition, cooperation, institutions, rituals, and the psychological differences between populations. Recognizing that we are a cultural species means that, even in the short run (when genes don’t have enough time to change), institutions, technologies, and languages are coevolving with psychological biases, cognitive abilities, emotional responses, and preferences. In the longer run, genes are evolving to adapt to these culturally constructed worlds, and this has been, and is now, the primary driver of human genetic evolution. Figure 17.1.

Over a decade prior, horrific cancer had deprived the world of an angel. My mother’s death had come quickly and unexpectedly. There was nothing that could be done to save her. She was admitted to the hospital, and a week later, she was gone, stolen from her beloved family and friends by the cells of her own body. Cells that had morphed from friend to mutant foe. Cells that, without remorse, mustered into a rogue army that cared nothing about extinguishing one of humanity’s true lights of kindness, compassion, and love. Malfunctions of biology and physiology had left only wonderful memories as well as the persistence of beauty in the lives she had touched.

Adults who faced early life stress show greater erosion in what’s known as telomeres—which are protective caps that sit on the ends of strands of DNA to keep DNA healthy and intact. As telomeres erode, we’re more likely to develop disease, and we age faster. As our telomeres age and expire, our cells expire, and eventually, so do we.

The multiplicity of human identity is not just a spiritual principle, it’s a biological fact—a basic ecological reality. ... only 10% of the cells in your body belong to you. The rest are the cells of bacteria and microorganisms that call your body home, and without these symbionts living on and within your physical self, you would be unable to digest and process the nutrients necessary to keep you alive. Your physical body is teeming with a microscopic diversity of life that rivals a rainforest. The insight of the Gaia Theory—that “the Earth system behaves as a single self-regulating system comprised of physical, chemical, biological and human components”—is as much a statement about our own physical bodies as it is about the planet. If we imagine the Earth as the body of a goddess, we can also imagine our own bodies as a sacred home to an ecologically complex and diverse array of microscopic life." -- Alison Leigh Lilly, "Naming the Water: Human and Deity Identity from an Earth-Centered Perspective

examines how we either live in the anticipation of future events or repeatedly revisit past memories (or both) until the body begins to believe it is living in a time other than the present moment. The latest research supports the notion that we have a natural ability to change the brain and body by thought alone, so that it looks biologically like some future event has already happened. Because you can make thought more real than anything else, you can change who you are from brain cell to gene, given the right understanding. When you learn how to use your attention and access the present, you will enter through the door to the quantum field, where all potentials exist.

Chloroplasts bear chlorophyll; they give the green world its color, and they carry out the business of photosynthesis. Around the inside perimeter of each gigantic cell trailed a continuous loop of these bright green dots. They spun . . . they pulsed, pressed, and thronged . . . they shone, they swarmed in ever-shifting files around and around the edge of the cell; they wandered, they charged, they milled, raced . . . they flowed and trooped greenly . . . All the green in the planted world consists of these whole, rounded chloroplasts . . . If you analyze a molecule of chlorophyll itself, what you get is one hundred thirty-six atoms of hydrogen, carbon, oxygen, and nitrogen arranged in an exact and complex relationship around a central ring. At the ring’s center is a single atom of magnesium. Now: If you remove the atom of magnesium and in its place put an atom of iron, you get a molecule of hemoglobin. The iron atom combines with all the other atoms to make red blood, the streaming red dots in the goldfish’s tail.

Humanity shares a common ancestry with all living things on Earth. We often share especially close intimacies with the microbial world. In fact, only a small percentage of the cells in the human body are human at all. Yet, the common biology and biochemistry that unites us also makes us susceptible to contracting and transmitting infectious disease.

...because the great beauty of embryo development, the bit that human beings find so hard to grasp, is that it is a totally decentralised process...no cell need wait for instructions from authority; every cell can act on its own information and the signals it receives from its neighbours. We do not organise societies that way...Perhaps we should try.

Despite the intervening six decades of scientific inquiry since Selye’s groundbreaking work, the physiological impact of the emotions is still far from fully appreciated. The medical approach to health and illness continues to suppose that body and mind are separable from each other and from the milieu in which they exist. Compounding that mistake is a definition of stress that is narrow and simplistic. Medical thinking usually sees stress as highly disturbing but isolated events such as, for example, sudden unemployment, a marriage breakup or the death of a loved one. These major events are potent sources of stress for many, but there are chronic daily stresses in people’s lives that are more insidious and more harmful in their long-term biological consequences. Internally generated stresses take their toll without in any way seeming out of the ordinary. For those habituated to high levels of internal stress since early childhood, it is the absence of stress that creates unease, evoking boredom and a sense of meaninglessness. People may become addicted to their own stress hormones, adrenaline and cortisol, Hans Selye observed. To such persons stress feels desirable, while the absence of it feels like something to be avoided. When people describe themselves as being stressed, they usually mean the nervous agitation they experience under excessive demands — most commonly in the areas of work, family, relationships, finances or health. But sensations of nervous tension do not define stress — nor, strictly speaking, are they always perceived when people are stressed. Stress, as we will define it, is not a matter of subjective feeling. It is a measurable set of objective physiological events in the body, involving the brain, the hormonal apparatus, the immune system and many other organs. Both animals and people can experience stress with no awareness of its presence. “Stress is not simply nervous tension,” Selye pointed out. “Stress reactions do occur in lower animals, and even in plants, that have no nervous systems…. Indeed, stress can be produced under deep anaesthesia in patients who are unconscious, and even in cell cultures grown outside the body.” Similarly, stress effects can be highly active in persons who are fully awake, but who are in the grip of unconscious emotions or cut off from their body responses. The physiology of stress may be triggered without observable effects on behaviour and without subjective awareness, as has been shown in animal experiments and in human studies.

A nutritive centre, anatomically considered, is merely a cell, the nucleus of which is the permanent source of successive broods of young cells, which from time to time fill the cavity of their parent, and carrying with them the cell wall of the parent, pass off in certain directions, and under various forms, according to the texture or organ of which their parent forms a part.

In Molecules of Emotion, Pert revealed how her study of information-processing receptors on nerve cell membranes led her to discover that the same “neural” receptors were present on most, if not all, of the body’s cells. Her elegant experiments established that the “mind” was not focused in the head but was distributed via signal molecules to the whole body. As importantly, her work emphasized that emotions were not only derived through a feedback of the body’s environmental information. Through self-consciousness, the mind can use the brain to generate “molecules of emotion” and override the system. While proper use of consciousness can bring health to an ailing body, inappropriate unconscious control of emotions can easily make a healthy body diseased,

In the first scenario, when the cell makes new receptor sites, the body will crave those specific chemicals when the brain doesn’t make enough, and consequently, our feelings will determine our thinking—our bodies will control our minds. That’s what I mean when I say the body memorizes the emotion. It has become biologically conditioned and altered to be a reflection of the mind.

nine of every ten cells in our bodies belong not to us, but to these microbial species (most of them residents of our gut), and that 99 percent of the DNA we’re carrying around belongs to those microbes. Some scientists, trained in evolutionary biology, began looking at the human individual in a humbling new light: as a kind of superorganism, a community of several hundred coevolved and interdependent species.

On every trip to Kya's, Tate took school or library books, especially on marsh creatures and biology. Her progress was startling. She could read anything now, her said, and once you can read anything you can learn everything. It was up to her. "Nobody's come close to filling their brains," he said. "We're all like giraffes not using their necks to reach the higher leaves." Alone for hours, by the light of the lantern, Kya read how plants and animals change over time to adjust to the ever-shifting earth; how some cells divide and specialize into lungs or hearts, while others remain uncommitted as stem cells in case they're needed later. Birds sing mostly at dawn because the cool, moist air of morning carries their songs and their meanings much farther. All her life, she'd seen these marvels at eye level, so nature's ways came easily to her.

Humans are not biological robots. We live for meaning, for the personal value of every experience. The body metabolizes our experiences and sends the message to every cell, while the mind, in its own domain, processes experience in terms of sensations, images, thoughts, and feelings. Nothing fuses the whole-system effects of love and non-love like the human heart, which needs to be understood as more than a physical organ.

For example, a computer virus is a program that will make copies of itself in the memory of a computer, and will transfer itself to other computers. Thus it fits the definition of a living system that I have given. Like a biological virus, it is a rather degenerate form, because it contains only instructions or genes, and doesn’t have any metabolism of its own. Instead, it reprograms the metabolism of the host computer, or cell.

The problem with racial discrimination, though, is not the inference of a person's race from their genetic characteristics. It is quite the opposite: it is the inference of a person's characteristics from their race. The question is not, can you, given an individual's skin color, hair texture, or language, infer something about their ancestry or origin. That is a question of biological systematics -- of lineage, taxonomy, of racial geography, of biological discrimination. Of course you can -- and genomics as vastly refined that inference. You can scan any individual genome and infer rather deep insights about a person's ancestry, or place of origin. But the vastly more controversial question is the converse: Given a racial identity -- African or Asian, say -- can you infer anything about an individual's characteristics: not just skin or hair color, but more complex features, such as intelligence, habits, personality, and aptitude? /I/ Genes can certainly tell us about race, but can race tell us anything about genes? /i/ To answer this question, we need to measure how genetic variation is distributed across various racial categories. Is there more diversity _within_ races or _between_ races? Does knowing that someone is of African versus European descent, say, allow us to refine our understanding of their genetic traits, or their personal, physical, or intellectual attributes in a meaningful manner? Or is there so much variation within Africans and Europeans that _intraracial_ diversity dominates the comparison, thereby making the category "African" or "European" moot? We now know precise and quantitative answers to these questions. A number of studies have tried to quantify the level of genetic diversity of the human genome. The most recent estimates suggest that the vast proportion of genetic diversity (85 to 90 percent) occurs _within_ so-called races (i.e., within Asians or Africans) and only a minor proportion (7 percent) within racial groups (the geneticist Richard Lewontin had estimated a similar distribution as early as 1972). Some genes certainly vary sharply between racial or ethnic groups -- sickle-cell anemia is an Afro-Caribbean and Indian disease, and Tay-Sachs disease has a much higher frequency in Ashkenazi Jews -- but for the most part, the genetic diversity within any racial group dominates the diversity between racial groups -- not marginally, but by an enormous amount. The degree of interracial variability makes "race" a poor surrogate for nearly any feature: in a genetic sense, an African man from Nigria is so "different" from another man from Namibia that it makes little sense to lump them into the same category.

What an unlikely wonder is life, that it holds in itself the whole wildness of death – those bacteria didn’t come into life at the point of death, they were always there and they always wanted to eat you, and your cells always contained in them the enzymes that would assist your rotting. It was only ever your vehemence to survive that prevented all that. Did you know, were you ever able to detect within, the passionate warfare that kept you here?

Yes, man is a physical being. But already, on the first page of the Bible, we learn that man can’t be explained as a merely physical being—a collection of cells, tissues, and organs. Human beings transcend the categories of chemistry and biology. Ultimately, man can only be understood in relation to God. This great mystery of creation—that we are created in God’s image—is the key reference point for understanding all aspects of humanity, including our sexuality.

and I am convinced that healthy emotional boundaries—such as being clear and vocal about what you will and will not let into your life—are what make relationships functional. Your gut lining is a boundary between you and everything else in the universe that is poised to inundate and overwhelm your biology and generate unrelenting inflammation. Healing and strengthening your gut lining with food—therefore creating and strengthening this critical boundary and reducing intestinal permeability or “leaky gut”—allows you to be selective about what you want to take in from the universe on a material level. You can choose what serves you. I reflect on the fact that many of the problems in society—including violence, mental illness, developmental issues, and pain—start in humans, and humans are made by cells that become dysfunctional largely because of oxidative stress, mitochondrial dysfunction, and chronic inflammation. How miraculous that food can directly combat those things. We can’t have a healthy society without well-functioning humans. We can’t have well-functioning humans without well-functioning cells. And we can’t have well-functioning cells with mitochondrial dysfunction, oxidative stress, chronic inflammation, and cellular and hormone disruption from toxic chemicals in our food. We combat those things through nutrient-dense, unprocessed foods grown in living, thriving soil.

Proto-oncogenes and tumor suppressors are the molecular pivots of the cell. They are the gatekeepers of cell division, and the division of cells is so central to our physiology that genes and pathways that coordinate this process intersect with nearly every other aspect of our biology. In the laboratory, we call this the six-degrees-of-separation-from-cancer rule: you can ask any biological question, no matter how seemingly distant—what makes the heart fail, or why

Order Out of Chaos ... At the right temperature ... two peptide molecules will stay together long enough on average to find a third. Then the little trio finds a fourth peptide to attract into the little huddle, just through the random side-stepping and tumbling induced by all the rolling water molecules. Something extraordinary is happening: a larger structure is emerging from a finer system, not in spite of the chaotic and random motion of that system but because of it. Without the chaotic exploration of possibilities, the rare peptide molecules would never find each other, would never investigate all possible ways of aggregating so that the tape-like polymers emerge as the most likely assemblies. It is because of the random motion of all the fine degrees of freedom that the emergent, larger structures can assume the form they do. Even more is true when the number of molecules present becomes truly enormous, as is automatically the case for any amount of matter big enough to see. Out of the disorder emerges a ... pattern of emergent structure from a substrate of chaos.... The exact pressure of a gas, the emergence of fibrillar structures, the height in the atmosphere at which clouds condense, the temperature at which ice forms, even the formation of the delicate membranes surrounding every living cell in the realm of biology -- all this beauty and order becomes both possible and predictable because of the chaotic world underneath them.... Even the structures and phenomena that we find most beautiful of all, those that make life itself possible, grow up from roots in a chaotic underworld. Were the chaos to cease, they would wither and collapse, frozen rigid and lifeless at the temperatures of intergalactic space. This creative tension between the chaotic and the ordered lies within the foundations of science today, but it is a narrative theme of human culture that is as old as any. We saw it depicted in the ancient biblical creation narratives of the last chapter, building through the wisdom, poetic and prophetic literature. It is now time to return to those foundational narratives as they attain their climax in a text shot through with the storm, the flood and the earthquake, and our terrifying ignorance in the face of a cosmos apparently out of control. It is one of the greatest nature writings of the ancient world: the book of Job.

The extracellular genesis of cells in animals seemed to me, ever since the publication of the cell theory [of Schwann], just as unlikely as the spontaneous generation of organisms. These doubts produced my observations on the multiplication of blood cells by division in bird and mammalian embryos and on the division of muscle bundles in frog larvae. Since then I have continued these observations in frog larvae, where it is possible to follow the history of tissues back to segmentation.

Years ago, however, with the development of lipid nanoparticles (LNPs), molecules were found that could act as brain-penetrating packaging material; that is, they could cross the blood-brain barrier. Their original use was to deliver chemotherapeutic drugs to the brain for the treatment of brain tumors (see sidebar Brain Toxic Packaging).37 It was no secret that LNPs could also be used to deliver genetic material in the form of DNA or mRNA to the brain or brain cells to become biologically active.

The biological universe was full of molecules picking out their partners like clever locks designed to fit a key: toxins clinging inseparably to antitoxins, dyes that highlighted only particular parts of cells, chemical stains that could nimbly pick out one class of germs from a mixture of microbes. If biology was an elaborate mix-and-match game of chemicals, Ehrlich reasoned, what if some chemical could discriminate bacterial cells from animal cells--and kill the former without touching the host?

Like a biological virus, it is a rather degenerate form, because it contains only instructions or genes, and doesn’t have any metabolism of its own. Instead, it reprograms the metabolism of the host computer, or cell. Some people have questioned whether viruses should count as life, because they are parasites, and cannot exist independently of their hosts. But then most forms of life, ourselves included, are parasites, in that they feed off and depend for their survival on other forms of life. I think computer viruses should count as life.

are biased toward studying individual organisms. It is often difficult for scientists to grasp the idea that individual brains do not exist in nature. As much as one may adhere to the notion of the isolated self, humans have evolved as social creatures and are constantly regulating one another’s biology. Without mutually stimulating interactions, people (and neurons for that matter) wither and die. In neurons this process is called apoptosis (programmed cell death); in humans it is called failure to thrive, depression, or dying of a broken heart.

Can you prove to me that there's no God, professor?' 'I could prove there is no need for a god, which is the next best thing. The Big Bang is the explanation. The Big Bang followed by billions of years of evolution by natural selection.' 'But what was there before the Big Bang?' 'Nothing.' 'Surely that is based on belief, too. You believe there was nothing. You cannot prove it.' 'Just as there are laws of physics, so there are laws of biology and the main one, the one which explains every living thing on the planet - and every planet in the universe, for that matter - is that all things must start simply and become complex. The complex dolphin began its evolutionary journey hundreds of millions of years ago as a simple, single-celled prokaryote. For a god to create the universe he would have to be hyper intelligent. But intelligence only evolves over time. The argument for a god starts by assuming what it is attempting to explain - intelligence, complexity, it amounts to the same thing - and so it explains nothing. God is a non-explanation. The Big Bang followed by billions of years of evolution is an explanation.

here’s a highly simplified version of the next chapter’s focus on genes: (a) each gene specifies the production of a specific type of protein; (b) a gene has to be “activated” for the protein to be produced and “deactivated” to stop producing it—thus genes come with on/off switches; (c) every cell in our bodies contains the same library of genes; (d) during development, the pattern of which genes are activated determines which cells turn into nose, which into toes, and so on; (e) forever after, nose, toes, and other cells retain distinctive patterns of gene activation.

If you weren’t an android,” Rick interrupted, “if I could legally marry you, I would.” Rachael said, “Or we could live in sin, except that I’m not alive.” “Legally you’re not. But really you are. Biologically. You’re not made out of transistorized circuits like a false animal; you’re an organic entity.” And in two years, he thought, you’ll wear out and die. Because we never solved the problem of cell replacement, as you pointed out. So I guess it doesn’t matter anyhow. This is my end, he said to himself. As a bounty hunter. After the Batys there won’t be any more. Not after this, tonight. “You look so sad,” Rachael said. Putting his hand out, he touched her cheek. “You’re not going to be able to hunt androids any longer,” she said calmly. “So don’t look sad. Please.” He stared at her. “No bounty hunter ever has gone on,” Rachael said. “After being with me. Except one. A very cynical man. Phil Resch. And he’s nutty; he works out in left field on his own.” “I see,” Rick said. He felt numb. Completely. Throughout his entire body. “But this trip we’re taking,” Rachael said, “won’t be wasted, because you’re going to meet a wonderful, spiritual man.

The Newtonian model of biology is based on linear events in which chemical reactions occur in a sequence of steps. But that’s not actually how biology works; you can no longer explain something even as simple as how a cut heals without the understanding of the interconnected coherent information pathways you just read about. Cells share an intercommunication of information in a nonlinear way. The universe and all the biological systems within it share an integration of independent, entangled energy fields that, in turn, share information beyond space and time on a moment-to-moment basis.

Cancer may be seen as a disease of cell replication. The normal processes of cell division and cell death are somehow subverted. A cell that should give rise to healthy offspring escapes from control and divides into malformed facsimiles that replicate themselves without regard to the biological needs of the organism. With millions of cells dying or being formed in the body every day, natural accident would, by itself, lead to a great number of spontaneous abnormal transformations. “It’s a fact that every one of us has a number of tiny cancerous tumours growing in our bodies at every moment,” writes Candace Pert.

Yes, all the interesting things in the world can be shot through with chaoticism, including a cell, an organ, an organism, a society. And as a result, there are really important things that can’t be predicted, that can never be predicted. But nonetheless, every step in the progression of a chaotic system is made of determinism, not whim. And yes, take a huge number of simple component parts that interact in simple ways, let them interact, and stunningly adaptive complexity emerges. But the component parts remain precisely as simple, and they can’t transcend their biological constraints to contain magical things like free will

As in any layered system, however, the system can become jeopardized if a core component that transfers information from one layer to another malfunctions. In the case of biological tissue, if the kinds of proteins that connect cells together are defective, then information may not be able to transfer from the individual-cell layer to the tissue layer, and the entire system could shut down. While not perfect, the layered design of biological systems is advantageous because it minimizes the number of points in the system that, if attacked, would result in catastrophic damage, and it limits the effects of attacks at other points.

This process, exquisitely beautiful and seemingly simple, is full of problems for biology. What organizes the growth? What is the control factor? How does the blastema "know" that it must make a foreleg in-stead of a bind leg? (The salamander never makes a mistake.) How does all the information about the missing parts get to these undifferentiated cells, telling them what to become, which genes to activate, what proteins to make, where to position themselves? It's as if a pile of bricks were to spontaneously rearrange itself into a building, becoming not only walls but windows, light sockets, steel beams, and furniture in the process.

Astounding, really, that Michel could consider psychology any kind of science at all. So much of it consisted of throwing together. Of thinking of the mind as a steam engine, the mechanical analogy most ready to hand during the birth of modern psychology. People had always done that when they thought about the mind: clockwork for Descartes, geological changes for the early Victorians, computers or holography for the twentieth century, AIs for the twenty-first…and for the Freudian traditionalists, steam engines. Application of heat, pressure buildup, pressure displacement, venting, all shifted into repression, sublimation, the return of the repressed. Sax thought it unlikely steam engines were an adequate model for the human mind. The mind was more like—what?—an ecology—a fellfield—or else a jungle, populated by all manner of strange beasts. Or a universe, filled with stars and quasars and black holes. Well—a bit grandiose, that—really it was more like a complex collection of synapses and axons, chemical energies surging hither and yon, like weather in an atmosphere. That was better—weather—storm fronts of thought, high-pressure zones, low-pressure cells, hurricanes—the jet streams of biological desires, always making their swift powerful rounds…life in the wind. Well. Throwing together. In fact the mind was poorly understood.

The history of the knowledge of the phenomena of life and of the organized world can be divided into two main periods. For a long time anatomy, and particularly the anatomy of the human body, was the a and ? of scientific knowledge. Further progress only became possible with the discovery of the microscope. A long time had yet to pass until through Schwann the cell was established as the final biological unit. It would mean bringing coals to Newcastle were I to describe here the immeasurable progress which biology in all its branches owes to the introduction of this concept of the cell. For this concept is the axis around which the whole of the modem science of life revolves.

The disgusting smell of death of death is the result of certain airborne molecules with evocative names like cadaverine and putrescine. These molecules are not produced by death, however, but by life growing on death. After an animal dies, its cells self destruct and become food for the body's resident bacteria. They chew through the walls of the gut and spread through the body. They release cadaverine and putrescine merely as byproducts of their metabolism. These molecules are not actually dangerous to us. They won't kill us like a whiff of sarin or cyanide. Yet our ancestors evolved a keen sensitivity to these molecules, along with an instinctive response to recoil at the merest whiff.

My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.

using a virus that could glue cells together, they fused the B cell with a cancer cell. I am still awestruck by the idea. How did they even think of using the undead to resuscitate the dying? The result was one of the strangest cells in biology. The plasma cell retained its antibody-secreting property, while the cancer cell conferred its immortality. They called their peculiar cell a hybridoma—a, well, hybrid of hybrid and oma, the suffix of carcinoma. The immortal plasma cell was now capable of perpetually secreting only one kind of antibody. We call this antibody of a single type (in other words, a clone), a monoclonal antibody. Milstein and Köhler’s paper was published in Nature in 1975.

He postulated that many neurons can combine into a coalition, becoming a single processing unit. The connection patterns of these units, which can change, make up the algorithms (which can also change with the changing connection patterns) that determine the brain’s response to a stimulus. From this idea came the mantra “Cells that fire together wire together.” According to this theory, learning has a biological basis in the “wiring” patterns of neurons. Hebb noted that the brain is active all the time, not just when stimulated; inputs from the outside can only modify that ongoing activity. Hebb’s proposal made sense to those designing artificial neural networks, and it was put to use in computer programs.

Things I worried about on the bus: a snapshot of an anxious brain . . . Is that car slowing down? Is someone going to get out and kidnap me? It is slowing down. What if someone asks for directions? What if—Oh. They’re just dropping someone off. The bus is late. What if it doesn’t arrive? What if I’m late getting to school? Did I turn my straighteners off ? What if the bus isn’t running today and no one told me? Where’s the—oh. There’s the bus. Oh crap is that Rowan from Biology? What if he sees me? What if he wants to chat? Hide. Okay, he hasn’t seen me. He hasn’t seen me. What if he did see me and now he thinks I’m weird for not saying hi? Did I remember to clean out Rita’s bowl properly? What if she gets sick? One day Rita will die. One day I’ll die. One day everyone will die. What if I die today and everyone sees that my bra has a hole in it? What if the bus crashes? Where are the exits? Why is there an exit on the ceiling? What if that headache Dad has is a brain tumor? Would I live with Mum all the time if Dad died? Why am I thinking about my living arrangements instead of how horrible it would be if Dad died? What’s wrong with me? What if Rhys doesn’t like me? What if he does? What if we get together and we split up? What if we get together and don’t split up and then we’re together forever until we die? One day I’ll die. Did I remember to turn my straighteners off ? Yes. Yes. Did I? Okay my stop’s coming up. I need to get off in about two minutes. Should I get up now? Will the guy next to me get that I have to get off or will I have to ask him to move? But what if he’s getting off too and I look like a twat? What if worrying kills brain cells? What if I never get to go to university? What if I do and it’s awful? Should I say thank you to the driver on the way off ? Okay, get up, move toward the front of the bus. Go, step. Don’t trip over that old man’s stick. Watch out for the stick. Watch out for the—shit. Did anyone notice that? No, no one’s looking at me. But what if they are? Okay, doors are opening, GO! I didn’t say thank you to the driver. What if he’s having a bad day and that would have made it better? Am I a bad person? Yeah but did I actually turn my straighteners off ?

Patriotism comes from the same Latin word as father. Blind patriotism is collective transference. In it the state becomes a parent and we citizens submit our loyalty to ensure its protection. We may have been encouraged to make that bargain from our public school education, our family home, religion, or culture in general. We associate safety with obedience to authority, for example, going along with government policies. We then make duty, as it is defined by the nation, our unquestioned course. Our motivation is usually not love of country but fear of being without a country that will defend us and our property. Connection is all-important to us; excommunication is the equivalent of death, the finality we can’t dispute. Healthy adult loyalty is a virtue that does not become blind obedience for fear of losing connection, nor total devotion so that we lose our boundaries. Our civil obedience can be so firm that it may take precedence over our concern for those we love, even our children. Here is an example: A young mother is told by the doctor that her toddler is allergic to peanuts and peanut oil. She lets the school know of her son’s allergy when he goes to kindergarten. Throughout his childhood, she is vigilant and makes sure he is safe from peanuts in any form. Eighteen years later, there is a war and he is drafted. The same mother, who was so scrupulously careful about her child’s safety, now waves goodbye to him with a tear but without protest. Mother’s own training in public school and throughout her life has made her believe that her son’s life is expendable whether or not the war in question is just. “Patriotism” is so deeply ingrained in her that she does not even imagine an alternative, even when her son’s life is at stake. It is of course also true that, biologically, parents are ready to let children go just as the state is ready to draft them. What a cunning synchronic-ity. In addition, old men who decide on war take advantage of the timing too. The warrior archetype is lively in eighteen-year-olds, who are willing to fight. Those in their mid-thirties, whose archetype is being a householder and making a mark in their chosen field, will not show an interest in battlefields of blood. The chiefs count on the fact that young braves will take the warrior myth literally rather than as a metaphor for interior battles. They will be willing to put their lives on the line to live out the collective myth of societies that have not found the path of nonviolence. Our collective nature thus seems geared to making war a workable enterprise. In some people, peacemaking is the archetype most in evidence. Nature seems to have made that population smaller, unfortunately. Our culture has trained us to endure and tolerate, not to protest and rebel. Every cell of our bodies learned that lesson. It may not be virtue; it may be fear. We may believe that showing anger is dangerous, because it opposes the authority we are obliged to appease and placate if we are to survive. This explains why we so admire someone who dares to say no and to stand up or even to die for what he believes. That person did not fall prey to the collective seduction. Watching Jeopardy on television, I notice that the audience applauds with special force when a contestant risks everything on a double-jeopardy question. The healthy part of us ardently admires daring. In our positive shadow, our admiration reflects our own disavowed or hidden potential. We, too, have it in us to dare. We can stand up for our truth, putting every comfort on the line, if only we can calm our long-scared ego and open to the part of us that wants to live free. Joseph Campbell says encouragingly, “The part of us that wants to become is fearless.” Religion and Transference Transference is not simply horizontal, from person to person, but vertical from person to a higher power, usually personified as God. When

The ancestors of the higher animals must be regarded as one-celled beings, similar to the Amoebae which at the present day occur in our rivers, pools, and lakes. The incontrovertible fact that each human individual develops from an egg, which, in common with those of all animals, is a simple cell, most clearly proves that the most remote ancestors of man were primordial animals of this sort, of a form equivalent to a simple cell. When, therefore, the theory of the animal descent of man is condemned as a 'horrible, shocking, and immoral' doctrine, tho unalterable fact, which can be proved at any moment under the microscope, that the human egg is a simple cell, which is in no way different to those of other mammals, must equally be pronounced 'horrible, shocking, and immoral.

Not all social animals are social with the same degree of commitment. In some species, the members are so tied to each other and interdependent as to seem the loosely conjoined cells of a tissue. The social insects are like this; they move, and live all their lives, in a mass; a beehive is a spherical animal. In other species, less compulsively social, the members make their homes together, pool resources, travel in packs or schools, and share the food, but any single one can survive solitary, detached from the rest. Others are social only in the sense of being more or less congenial, meeting from time to time in committees, using social gatherings as ad hoc occasions for feeding and breeding. Some animals simply nod at each other in passing, never reaching even a first-name relationship.

As a result of this conscious or unconscious process, your biology stays the same. Neither your brain nor your body changes at all, because you’re thinking the same thoughts, performing the same actions, and living by the same emotions—even though you may be secretly hoping your life will change. You create the same brain activity, which activates the same brain circuits and reproduces the same brain chemistry, which affects your body chemistry in the same way. And that same chemistry signals the same genes in the same ways. And the same gene expression creates the same proteins, the building blocks of cells, which keep the body the same (I’ll go into more on proteins later). And since the expression of proteins is the expression of life or health, your life and your health stay the same.

The role played by stress in the causation of cancer is so great that it would not be an exaggeration to say that 80% or more cancer cases have their immediate origin in some form of mental pressure or strain. Grief, distress, fear, worry, and anger are emotions which have horrible effects on the body's functions. Researchers have discovered that these emotions cause the release of chemicals from the brain called neuropeptides. These potent compounds have a profound immune-suppressive action. Scientists have traced a pathway from the brain to the immune cells proving that negative emotions can stop the immune cells dead in their tracks. This results in part from the release of chemicals from nerve endings. Once this happens, harmful microbes or cancer cells can invade any tissue in the body.

you and I having this conversation right now, and anyone reading the magazine, is part of an unbroken chain of communication – an interpretive process, with messages being exchanged millions of times per second, between cells and even organelles within cells, that stretches back, totally unbroken, 3.7 billion years. That’s 3.7 billion years of conversation going on between living structures in order to allow us to be here today. If there had ever been a break, even for a second, you wouldn’t be here. If you were looking for a metaphysical thought to give you a sense of overwhelming wonder, all you need is to meditate for a moment on the fact that you are part of this unbroken exchange, a conversation that goes all the way back to the puddle, or the clay-like substrate, that all life emerged from.

The DNA-RNA apparatus isn't the whole secret of life, but a sort of computer program by which the real secret, the control system, ex-presses its pattern in terms of living cells.This pattern is part of what many people mean by the soul, which somany philosophies have tried to explicate. However, most of the pro-posed answers haven't been connected with the physical world of biology in a way that offered a toehold for experiment. Like many attempts, the latest major scientific guess, the morphogenetic field proposed by Paul Weiss in 1939, was just a restatement of the problem, though a useful one. Weiss conjectured that development was guided by some sort of field projected from the fertilized egg. As the dividing cell mass became an embryo and then an adult, the field changed its shape and somehow led the cells onward.

Jack coughed slightly and offered his hand. “Hi, uh. I’m Jack.” Kim took it. “Jack what?” “Huh?” “Your last name, silly.” “Jackson.” She blinked at him. “Your name is Jack Jackson?” He blushed. “No, uh, my first name’s Rhett, but I hate it, so…” He gestured to the chair and she sat. Her dress rode up several inches, exposing pleasing long lines of creamy skin. “Well, Jack, what’s your field of study?” “Biological Engineering, Genetics, and Microbiology. Post-doc. I’m working on a research project at the institute.” “Really? Oh, uh, my apple martini’s getting a little low.” “I’ve got that, one second.” He scurried to the bar and bought her a fresh one. She sipped and managed to make it look not only seductive but graceful as well. “What do you want to do after you’re done with the project?” Kim continued. “Depends on what I find.” She sent him a simmering smile. “What are you looking for?” Immediately, Jack’s eyes lit up and his posture straightened. “I started the project with the intention of learning how to increase the reproduction of certain endangered species. I had interest in the idea of cloning, but it proved too difficult based on the research I compiled, so I went into animal genetics and cellular biology. It turns out the animals with the best potential to combine genes were reptiles because their ability to lay eggs was a smoother transition into combining the cells to create a new species, or one with a similar ancestry that could hopefully lead to rebuilding extinct animals via surrogate birth or in-vitro fertilization. We’re on the edge of breaking that code, and if we do, it would mean that we could engineer all kinds of life and reverse what damage we’ve done to the planet’s ecosystem.” Kim stared. “Right. Would you excuse me for a second?” She wiggled off back to her pack of friends by the bar. Judging by the sniggering and the disgusted glances he was getting, she wasn’t coming back. Jack sighed and finished off his beer, massaging his forehead. “Yes, brilliant move. You blinded her with science. Genius, Jack.” He ordered a second one and finished it before he felt smallish hands on his shoulders and a pair of soft lips on his cheek. He turned to find Kamala had returned, her smile unnaturally bright in the black lights glowing over the room. “So…how did it go with Kim?” He shot her a flat look. “You notice the chair is empty.” Kamala groaned. “You talked about the research project, didn’t you?” “No!” She glared at him. “…maybe…” “You’re so useless, Jack.” She paused and then tousled his hair a bit. “Cheer up. The night’s still young. I’m not giving up on you.” He smiled in spite of himself. “Yet.” Her brown eyes flashed. “Never.

One of the four genes used by Yamanaka to reverse cellular fate is called c-myc. Myc, the rejuvenating factor, is no ordinary gene: it is one of the most forceful regulators of cell growth and metabolism known in biology. Activated abnormally, it can certainly coax an adult cell back into an embryo-like state, thereby enabling Yamanaka's cell-fate reversal experiment (this function requires the collaboration of the three other genes found by Yamanaka). But myc is also one of the most potent cancer-causing genes known in biology; it is also activated in leukemias and lymphomas, and in pancreatic, gastric, and uterine cancer. As in some ancient moral fable, the quest for eternal youthfulness appears to come at a terrifying collateral cost. The very genes that enable a cell to peel away mortality and age can also tip its fate toward malignant immortality, perpetual growth, and agelessness-the hallmarks of cancer.

For everyday purposes, we know and can say, e.g., whether an animal is alive or not. But, upon closer inquiry, we find that this is, in many cases, a very complex question, as the jurists know very well. They have cudgelled their brains in vain to discover a rational limit beyond which the killing of the child in its mother's womb is murder. It is just as impossible to determine absolutely the moment of death, for physiology proves that death is not an instantaneous, momentary phenomenon, but a very protracted process. In like manner, every organized being is every moment the same and not the same; every moment, it assimilates matter supplied from without, and gets rid of other matter; every moment, some cells of its body die and others build themselves anew; in a longer or shorter time, the matter of its body is completely renewed, and is replaced by other molecules of matter, so that every organized being is always itself, and yet something other than itself.

What is especially striking about the earth is the way in which it contains time capsules nested within time capsules, like a Russian doll. Individual biological cells (properly interpreted) are time capsules from which biologists read genetic time. Organs within the body are again time capsules, and contain traces of the history and morphogenesis of our bodies. The body itself is a time capsule. History is written in a face, which carries a date - the approximate date of our birth. We can all tell the rough age of a person from a glance at their face. Wherever we look, we find mutually consistent time capsules - in grains of sand, in ripe cherries, in books in libraries. This consistent meshing of stories even extends far from the Earth and into the outermost reaches of the universe. The abundances of the chemical elements and isotopes in the gas of stars and the waters of the oceans tell the story of the stars and a Big Bang that created the lightest elements. It all fits together so well.

It is in our collective behavior that we are the most mysterious. We won't be able to construct machines like ourselves until we've understood this, and we're not even close. All we know is the phenomenon: we spend our time sending messages to each other, talking and trying to listen at the same time, exchanging information. This seems to be our most urgent biological function; it is what we do with our lives. By the time we reach the end, each of us has taken in a staggering store, enough to exhaust any computer, much of it incomprehensible, and we generally manage to put out even more than we take in. Information is our source of energy; we are driven by it. It has become a tremendous enterprise, a kind of energy system on its own. All 3 billion of us are being connected by telephones, radios, television sets, airplanes, satellites, harangues on public-address systems, newspapers, magazines, leaflets dropped from great heights, words got in edgewise. We are becoming a grid, a circuitry around the earth.

Superimposed on the hierarchical framework of defined components of a cell there is another layer. This second layer is highly flexible and can take on an almost infinite variety of forms, like soft and responsive flesh on a bony skeleton. The deep question is whether this higher layer in the construction of cells is itself organized. Are there hierarchies, or at least rules, in the protein-modifying, RNA splicing, gene-regulating processes of a cell? If so, then we have a chance of understanding them. If not, we will never know exactly what a cell will do next. If the detailed chemistry of the cell is simply the outcome of a historical ragbag of ad hoc interactions, then it will be no more predictable than the weather. I do not have an answer to this question. But two features of cells might be relevant. One is a sense of time, or causation - knowledge of the way that things in the real world follow in a certain sequence. The other is integrity, which enables a cell to distinguish between what belongs to itself and what belongs to the outside world.

Enzymes have made and unmade every single biomolecule inside every living cell that lives or has ever lived. Enzymes are as close as anything to the vital factors of life. So the discovery that some, and possibly all, enzymes work by promoting the dematerialization of particles from one point in space and their instantaneous materialization in another provides us with a novel insight into the mystery of life. And while there remain many unresolved issues related to enzymes that need to be better understood, such as the role of protein motions, there is no doubt that quantum tunneling plays a role in the way they work. Even so, we should address a criticism made by many scientists who accept the findings of Klinman, Scrutton and others, but nevertheless claim that quantum effects have as relevant a role in biology as they have in the workings of a steam train: they are always there but are largely irrelevant to understanding how either system works. Their argument is often positioned within a debate about whether or not enzymes evolved to take advantage of quantum phenomena such as tunneling. The

It is hard to feel affection for something as totally impersonal as the atmosphere, and yet there it is, as much a part and product of life as wine and bread. Taken all in al, the sky is a miraculous achievement. It works, and for what it is designed to accomplish it is as infallible as anything in nature. I doubt whether any of us could think of a way to improve on it, beyond maybe shifting a local cloud from here to there on occasion. The word 'chance' does not serve to account well for structures of such magnificence... We should credit it for what it is: for sheer size and perfection of function, it is far and away the grandest product of collaboration in all of nature. It breathes for us, and it does another thing for our pleasure. Each day, millions of meteorites fall against the outer limits of the membrane and are burned to nothing by the friction. Without this shelter, our surface would long since have become the pounded powder of the moon. Even though our receptors are not sensitive enough to hear it, there is comfort in knowing the sound is there overhead, like the random noise of rain on the roof at night.

Bergson, on s'en souvient, voyait dans l'évolution l'expression d'une force créatrice, absolue en ce sens qu'il ne la supposait pas tendue à une autre fin que la création en elle-même et pour elle-même. En cela il diffère radicalement des animistes (qu'il s'agisse d'Engels, de Teilhard ou des positivistes optimistes tels que Spencer) qui tous voient dans l'évolution le majestueux déroulement d'un programme inscrit dans la trame même de l'Univers. Pour eux, par conséquent, l'évolution n'est pas véritablement création, mais uniquement 'révélation' des intentions jusque-là inexprimées de la nature. D'où la tendance à voir dans le développement embryonnaire une émergence de même ordre que l'émergence évolutive. Selon la théorie moderne, la notion de 'révélation' s'applique au développement épigénétique, mais non, bien entendu, à l'émergence évolutive qui, grâce précisément au fait qu'elle prend sa source dans l'imprévisible essentiel, est créatrice de nouveauté absolue. Cette convergence apparente entre les voies de la métaphysique bergsonienne et celles de la science serait-elle encore l'effet d'une pure coïncidence? Peut-être pas: Bergson, en artiste et poète qu'il était, très bien informé par ailleurs des sciences naturelles de son temps, ne pouvait manquer d'être sensible à l'éblouissante richesse de la biosphère, à la variété prodigieuse des formes et des comportements qui s'y déploient, et qui paraissent témoigner presque directement, en effet, d'une prodigalité créatrice inépuisable, libre de toute contrainte. Mais là où Bergson voyait la preuve la plus manifeste que le 'principe de la vie' est l'évolution elle-même, la biologie moderne reconnaît, au contraire, que toutes les propriétés des êtres vivants reposent sur un mécanisme fondamental de conservation moléculaire. Pour la théorie moderne l'évolution n'est nullement une propriété des êtres vivants puisqu'elle a sa racine dans les imperfections mêmes du mécanisme conservateur qui, lui, constitute bien leur unique privilège. Il faut donc dire que la même source de perturbations, de 'bruit', qui, dans un système non vivant, c'est-à-dire non réplicatif, abolirait peu à peu toute structure, est à l'origine de l'évolution dans la biosphère, et rend compte de sa totale liberté créatrice, grâce à ce conservatoire du hasard, sourd au bruit autant qu'à la musique: la structure réplicative de l'ADN.

A living being like you or me usually has two elements: a set of instructions that tell the system how to keep going and how to reproduce itself, and a mechanism to carry out the instructions. In biology, these two parts are called genes and metabolism. But it is worth emphasising that there need be nothing bio-logical about them. For example, a computer virus is a program that will make copies of itself in the memory of a computer, and will transfer itself to other computers. Thus it fits the definition of a living system that I have given. Like a biological virus, it is a rather degenerate form, because it contains only instructions or genes, and doesn’t have any metabolism of its own. Instead, it reprograms the metabolism of the host computer, or cell. Some people have questioned whether viruses should count as life, because they are parasites, and cannot exist independently of their hosts. But then most forms of life, ourselves included, are parasites, in that they feed off and depend for their survival on other forms of life. I think computer viruses should count as life. Maybe it says something about human nature that the only form of life we have created so far is purely destructive. Talk about creating life in our own image. I shall return to electronic forms of life later on.

The human brain is the most complex entity in the universe. It has between fifty and one hundred billion nerve cells, or neurons, each branched to form thousands of possible connections with other nerve cells. It has been estimated that laid end to end, the nerve cables of a single human brain would extend into a line several hundred thousand miles long. The total number of connections, or synapses, is in the trillions. The parallel and simultaneous activity of innumerable brain circuits, and networks of circuits, produces millions of firing patterns each and every second of our lives. The brain has well been described as “a supersystcm of systems.” Even though fully half of the roughly hundred thousand genes in the human organism are dedicated to the central nervous system, the genetic code simply cannot carry enough information to predetermine the infinite number of potential brain circuits. For this reason alone, biological heredity could not by itself account for the densely intertwined psychology and neurophysiology of attention deficit disorder. Experience in the world determines the fine wiring of the brain. As the neurologist and neuroscientist Antonio Damasio puts it, “Much of each brain’s circuitry, at any given moment in adult life, is individual and unique, truly reflective of that particular organism’s history and circumstances.” This is no less true of children and infants. Not even in the brains of genetically identical twins will the same patterns be found in the shape of nerve cells or the numbers and configuration of their synapses with other neurons. The microcircuitry of the brain is formatted by influences during the first few years of life, a period when the human brain undergoes astonishingly rapid growth. Five-sixths of the branching of nerve cells in the brain occurs after birth. At times in the first year of life, new synapses are being established at a rate of three billion a second. In large part, each infant’s individual experiences in the early years determine which brain structures will develop and how well, and which nerve centers will be connected with which other nerve centers, and establish the networks controlling behavior. The intricately programmed interactions between heredity and environment that make for the development of the human brain are determined by a “fantastic, almost surrealistically complex choreography,” in the apt phrase of Dr. J. S. Grotstein of the department of psychiatry at UCLA. Attention deficit disorder results from the miswiring of brain circuits, in susceptible infants, during this crucial period of growth.

Responsibility has a role too. Even though my particles, and hence my behaviors, are under the full jurisdiction of physical law, “I” am in a very literal if unfamiliar way responsible for my actions. At any given moment, I am my collection of particles; “I” is nothing but a shorthand that signifies my specific particulate configuration (which, although dynamic, maintains sufficiently stable patterns to provide a consistent sense of personal identity45). Accordingly, the behavior of my particles is my behavior. That physics underlies this behavior through its control of my particles is surely interesting. That such behavior is not freely willed is worthy of acknowledgment. But these observations do not diminish the higher-level description which recognizes that my specific particle configuration—the way my particles are arranged into an intricate chemical and biological network including genes, proteins, cells, neurons, synaptic connections, and so on—responds in a manner that is unique to me. You and I speak differently, act differently, respond differently, and think differently because our particles are arranged differently. As my particle arrangement learns and thinks and synthesizes and interacts and responds, it imprints my individuality and stamps my responsibility on every action I take.

When General Genius built the first mentar [Artificial Intelligence] mind in the last half of the twenty-first century, it based its design on the only proven conscious material then known, namely, our brains. Specifically, the complex structure of our synaptic network. Scientists substituted an electrochemical substrate for our slower, messier biological one. Our brains are an evolutionary hodgepodge of newer structures built on top of more ancient ones, a jury-rigged system that has gotten us this far, despite its inefficiency, but was crying out for a top-to-bottom overhaul. Or so the General genius engineers presumed. One of their chief goals was to make minds as portable as possible, to be easily transferred, stored, and active in multiple media: electronic, chemical, photonic, you name it. Thus there didn't seem to be a need for a mentar body, only for interchangeable containers. They designed the mentar mind to be as fungible as a bank transfer. And so they eliminated our most ancient brain structures for regulating metabolic functions, and they adapted our sensory/motor networks to the control of peripherals. As it turns out, intelligence is not limited to neural networks, Merrill. Indeed, half of human intelligence resides in our bodies outside our skulls. This was intelligence the mentars never inherited from us. ... The genius of the irrational... ... We gave them only rational functions -- the ability to think and feel, but no irrational functions... Have you ever been in a tight situation where you relied on your 'gut instinct'? This is the body's intelligence, not the mind's. Every living cell possesses it. The mentar substrate has no indomitable will to survive, but ours does. Likewise, mentars have no 'fire in the belly,' but we do. They don't experience pure avarice or greed or pride. They're not very curious, or playful, or proud. They lack a sense of wonder and spirit of adventure. They have little initiative. Granted, their cognition is miraculous, but their personalities are rather pedantic. But probably their chief shortcoming is the lack of intuition. Of all the irrational faculties, intuition in the most powerful. Some say intuition transcends space-time. Have you ever heard of a mentar having a lucky hunch? They can bring incredible amounts of cognitive and computational power to bear on a seemingly intractable problem, only to see a dumb human with a lucky hunch walk away with the prize every time. Then there's luck itself. Some people have it, most don't, and no mentar does. So this makes them want our bodies... Our bodies, ape bodies, dog bodies, jellyfish bodies. They've tried them all. Every cell knows some neat tricks or survival, but the problem with cellular knowledge is that it's not at all fungible; nor are our memories. We're pretty much trapped in our containers.

We will not find the enemy.8 Because the enemy does not exist in space, but in time: four thousand years ago. We are about to destroy each other, and the world, because of profound mistakes made in Bronze Age patriarchal ontology—mistakes about the nature of being, about the nature of human being in the world. Evolution itself is a time-process, seemingly a relentlessly linear unfolding. But biology also dreams, and in its dreams and waking visions it outleaps time, as well as space. It experiences prevision, clairvoyance, telepathy, synchronicity. Thus we have what has been called a magical capacity built into our genes. It is built into the physical universe. Synchronicity is a quantum phenomenon. The tachyon is consciousness, which can move faster than light. So, built into our biological-physical selves evolving linearly through time and space, is an authentically magical capacity to move spirally, synchronously, multi-sensorially, simultaneously back and forth, up and down, in and out through all time and space. In our DNA is a genetic memory going back through time to the first cell, and beyond; back through space to the big bang (the cosmic egg), and before that. To evolve then—to save ourselves from species extinction—we can activate our genetic capacity for magic. We can go back in time to our prepatriarchal consciousness of human oneness with the earth. This memory is in our genes, we have lived it, it is ours. This

The unification of our understanding of life with our understanding of matter and energy was the greatest scientific achievement of the second half of the twentieth century. One of its many consequences was to pull the rug out from under social scientists like Kroeber and Lowie who had invoked the “sound scientific method” of placing the living and nonliving in parallel universes. We now know that cells did not always come from other cells and that the emergence of life did not create a second world where before there was just one. Cells evolved from simpler replicating molecules, a nonliving part of the physical world, and may be understood as collections of molecular machinery—fantastically complicated machinery, of course, but machinery nonetheless. This leaves one wall standing in the landscape of knowledge, the one that twentieth-century social scientists guarded so jealously. It divides matter from mind, the material from the spiritual, the physical from the mental, biology from culture, nature from society, and the sciences from the social sciences, humanities, and arts. The division was built into each of the doctrines of the official theory: the blank slate given by biology versus the contents inscribed by experience and culture, the nobility of the savage in the state of nature versus the corruption of social institutions, the machine following inescapable laws versus the ghost that is free to choose and to improve the human condition. But this wall, too, is falling.

Perhaps it is in this respect that language differs most sharply from other biologic systems for communication. Ambiguity seems to be an essential, indispensable element for the transfer of information from one place to another by words, where matters of real importance are concerned. It is often necessary, for meaning to come through, that there be an almost vague sense of strangeness and askewness. Speechless animals and cells cannot do this. The specifically locked-on antigen at the surface of a lymphocyte does not send the cell off in search of something totally different; when a bee is tracking sugar by polarized light, observing the sun as though consulting his watch, he does not veer away to discover an unimaginable marvel of a flower. Only the human mind is designed to work in this way, programmed to drift away in the presence of locked-on information, straying from each point in a hunt for a better, different point. If it were not for the capacity for ambiguity, for the sensing of strangeness, the words in all languages provide, we would have no way of recognizing the layers of counterpoint in meaning, and we might be spending all our time sitting on stone fences, staring into the sun. To be sure, we would always have had some everyday use to make of the alphabet, and we might have reached the same capacity for small talk, but it is unlikely that we would have been able to evolve from words to Bach. The great thing about human language is that it prevents us from sticking to the matter at hand.

Men cooperate with one another. The totality of interhuman relations engendered by such cooperation is called society. Society is not an entity in itself. It is an aspect of human action. It does not exist or live outside of the conduct of people. It is an orientation of human action. Society neither thinks nor acts. Individuais in thinking and acting constitute a complex of relations and facts that are called social relations and facts. The issue has been confused by an arithmetical metaphor. Is society, people asked, merely a sum of individuals or is it more than this and thereby an entity endowed with independent reality? The question is nonsensical. Society is neither the sum of individuais nor more nor less. Arithmetical concepts cannot be applied to the matter. Another confusion arises from the no less empty question whether society is—in logic and in time—anterior to individuais or not. The evolution of society and that of civilization were not two distinct processes but one and the same process. The biological passing of a species of primates beyond the levei of a mere animal existence and their transformation into primitive men implied already the development of the first rudiments of social cooperation. Homo sapiens appeared on the stage of earthly events neither as a solitary foodseeker nor as a member of a gregarious flock, but as a being consciously cooperating with other beings of his own kind. Only in cooperation with his fellows could he develop language, the indispensable tool of thinking. We cannot even imagine a reasonable being living in perfect isolation and not cooperating at least with members of his family, clan, or tribe. Man as man is necessarily a social animal. Some sort of cooperation is an essential characteristic of his nature. But awareness of this fact does not justify dealing with social relations as if they were something else than relations or with society as if it were an independent entity outside or above the actions of individual men. Finally there are the misconstructions caused by the organismic metaphor. We may compare society to a biological organism. The tertium comparationis is the fact that division of labor and cooperation exist among the various parts of a biological body as among the various members of society. But the biological evolution that resulted in the emergence of the structurefunction systems of plant and animal bodies was a purely physiological process in which no trace of a conscious activity on the part of the cells can be discovered. On the other hand, human society is an intellectual and spiritual phenomenon. In cooperating with their fellows, individuais do not divest themselves of their individuality. They retain the power to act antisocially, and often make use of it. Its place in the structure of the body is invariably assigned to each cell. But individuais spontaneously choose the way in which they integrate themselves into social cooperation. Men have ideas and seek chosen ends, while the cells and organs of the body lack such autonomy.

The Creation of Human Beings From Water Allah created every [living] creature from water. Some of them go on their bellies, some of them on two legs, and some on four. Allah creates whatever He wills. Allah has power over all things. (Qur'an, 24:45) Do those who disbelieve not see that the heavens and the Earth were sewn together and then We unstitched them and that We made from water every living thing? So won't they believe? (Qur'an, 21:30) And it is He Who created human beings from water and then gave them relations by blood and marriage. Your Lord is All-Powerful. (Qur'an, 25:54) When we look at the verses concerned with the creation of human beings and living things, we clearly see evidence of a miracle. One such miracle is of the creation of living things from water. It was only possible for people to come by that information, clearly expressed in those verses, hundreds of years afterwards with the invention of the microscope. Allah's Miracles in the Qur'an 165 The words "Water is the main component of organic matter. 50-90% of the weight of living things consists of water" appear regularly in encyclopaedias. Furthermore, 80% of the cytoplasm (basic cell material) of a standard animal cell is described as water in biology textbooks. The analysis of cytoplasm and its appearance in textbooks took place hundreds of years after the revelation of the Qur'an. It is therefore impossible for this fact, now accepted by the scientific community, to have been known at the time the Qur'an was revealed. Yet, attention was drawn to it in the Qur'an 1,400 years before its discovery.

By habitus, I mean dispositions that inhere and mold the deepest, subtlest, intricate structures of personhood, are constituted and emergent in the most elusive folds and lineaments of consciousness, and are articulated in lastingly resilient, enduring textual tapestries of experience, orientations, desires. The range of habitus is deep and broad: habitus forms the long arc of evolutionary developments and arrangements of the body in action and at rest, posture, gait, stance, and gesture; it is the silent teacher of the phonemic alphabet, determining subtle distinctions of timbre and tone, accents and intonations in voice articulations; it is the subcutaneous, ingrained dynamic inhering in daily competencies, executed flawlessly and yet seemingly unconsciously, such as balancing huge loads the size of a person’s body weight on the head as Kikuyu women often do, or walking fearlessly on narrow glacial paths through plunging cliffs as the Sherpas do, or weaving in and out of traffic while engaged in deep conversations on a cell phone as Californians do. Habitus describes the imbrication of structure and culture in desire. It is what defines subtle distinctions of taste, those almost ineffable differences of sweetness, succulence, spiciness, and bitterness in food and drink; the raging fetishes and unbidden cravings that shadow sexuality; the fickle difference between scents that intoxicate or trigger upheavals of wretching. Habitus, then, is “human nature” understood as the deep penetration of sociality with biology in such a manner that it is the motor of self, of choice, of vocation.

The watcher’s eyes are likely to swivel forward in a sequence of stately turns as the screen’s pixel glows: each quarter-ounce mass of eyeball tugged by six flat muscles, in a glissando slide within the slippery fat lining the orbital cavity. The eye blinks, the widened pupils are in position, and the incoming electromagnetic waves roar in. Ripping through the thin layer of the cornea, they decelerate slightly, with their outermost edges forming a nearly flat plane as they travel inward, carrying the as-yet-undetected signal from the screen deep into the waiting human. The waves continue through the liquid of the aqueous humor and on to the gaping hole of the pupil. The human may have squinted to avoid the glare, but human reflexes work at the rate of slow thousandths of a second and are no match for these racing intruders. The pupil is crossed without obstruction. The stiff lens just below focuses the incoming waves even more, sending them into the inland sea of the jellylike vitreous humor deeper down in the eye. A very few of the incoming electric waves explode against the organic molecules in their way, but most simply whirl through those soft biological barriers and continue straight down, piercing the innermost wrapping of the eyeball, till they reach the end-point of their journey: the fragile, stalklike projection from the living brain known as the retina. And deep inside there, in the dark, barely slowed from their original 670 million mph, the waves splatter into the ancient, moist blood vessels and cell membranes, and something unexpected happens. An electric current switches on.

Statistically, the probability of any one of us being here is so small that you'd think the mere fact of existing would keep us all in a contented dazzlement of surprise. We are alive against the stupendous odds of genetics, infinitely outnumbered by all the alternates who might, except for luck, be in our places. Even more astounding is our statistical improbability in physical terms. The normal, predictable state of matter throughout the universe is randomness, a relaxed sort of equilibrium, with atoms and their particles scattered around in an amorphous muddle. We, in brilliant contrast, are completely organized structures, squirming with information at every covalent bond. We make our living by catching electrons at the moment of their excitement by solar photons, swiping the energy released at the instant of each jump and storing it up in intricate loops fro ourselves. We violate probability, by our nature. To be able to do this systematically, and in such wild varieties of form, from viruses to whales, is extremely unlikely; to have sustained the effort successfully for the several billion years of our existence, without drifting back into randomness, was nearly a mathematical impossibility. Add to this the biological improbability that makes each member of our own species unique. Everyone is one in 3 billion at the moment, which describes the odds. Each of us is a self-contained, free-standing individual, labeled by specific protein configurations at the surfaces of cells, identifiable by whorls of fingertip skin, maybe even by special medleys of fragrance. You'd think we'd never stop dancing.

In other words, if we believe we can or we believe we can’t, we are right. Belief itself is the key. To reiterate: positive thinking alone has no power. Belief must include our heart. We can make the choice for life by believing the Lord and dealing with any barriers that prevent us from receiving the promises of God. This is why God says in His Word: “I have set before you life and death, blessing and cursing; therefore choose life” (Deut. 30:19). The healing power of the Divine Healer is in our own heart: “All things are possible to him who believes” (Mark 9:23). We make the connection with Him through our belief. “All things are possible to him who believes!” PRACTICE PRAY: PRAYER STEP 1 Notice that when you close your eyes to pray, your focus shifts from your head to your spiritual heart in your belly (see John 7:38 KJV). Yield to Christ within. PRACTICE: Pray Prayer is fellowship with a Person. Come into the presence of the Divine Healer to honor Him. Pray. Close your eyes and pray, placing your hand on your belly. Focus. Focus on Christ within. Feel peace. Yield and feel peace. RECEIVE: PRAYER STEP 2 PRACTICE: Receive Pray. Close your eyes and pray, placing your hand on your belly. Yield. Yield to the Divine Healer in your heart. Receive. Welcome healing into every cell of your body. TROUBLESHOOTING REMOVING FEAR Pray. Close your eyes and pray, placing your hand on your belly. First. You may see a situation, another person, or yourself. Feel. Allow yourself to feel the fear momentarily. Forgive. Receive forgiveness for taking in fear (see 1 John 4:18). ENDNOTES   1. “More than 9 in 10 Americans continue to believe

The Company We Keep So now we have seen that our cells are in relationship with our thoughts, feelings, and each other. How do they factor into our relationships with others? Listening and communicating clearly play an important part in healthy relationships. Can relationships play an essential role in our own health? More than fifty years ago there was a seminal finding when the social and health habits of more than 4,500 men and women were followed for a period of ten years. This epidemiological study led researchers to a groundbreaking discovery: people who had few or no social contacts died earlier than those who lived richer social lives. Social connections, we learned, had a profound influence on physical health.9 Further evidence for this fascinating finding came from the town of Roseto, Pennsylvania. Epidemiologists were interested in Roseto because of its extremely low rate of coronary artery disease and death caused by heart disease compared to the rest of the United States. What were the town’s residents doing differently that protected them from the number one killer in the United States? On close examination, it seemed to defy common sense: health nuts, these townspeople were not. They didn’t get much exercise, many were overweight, they smoked, and they relished high-fat diets. They had all the risk factors for heart disease. Their health secret, effective despite questionable lifestyle choices, turned out to be strong communal, cultural, and familial ties. A few years later, as the younger generation started leaving town, they faced a rude awakening. Even when they had improved their health behaviors—stopped smoking, started exercising, changed their diets—their rate of heart disease rose dramatically. Why? Because they had lost the extraordinarily close connection they enjoyed with neighbors and family.10 From studies such as these, we learn that social isolation is almost as great a precursor of heart disease as elevated cholesterol or smoking. People connection is as important as cellular connections. Since the initial large population studies, scientists in the field of psychoneuroimmunology have demonstrated that having a support system helps in recovery from illness, prevention of viral infections, and maintaining healthier hearts.11 For example, in the 1990s researchers began laboratory studies with healthy volunteers to uncover biological links to social and psychological behavior. Infected experimentally with cold viruses, volunteers were kept in isolation and monitored for symptoms and evidence of infection. All showed immunological evidence of a viral infection, yet only some developed symptoms of a cold. Guess which ones got sick: those who reported the most stress and the fewest social interactions in their “real life” outside the lab setting.12 We Share the Single Cell’s Fate Community is part of our healing network, all the way down to the level of our cells. A single cell left alone in a petri dish will not survive. In fact, cells actually program themselves to die if they are isolated! Neurons in the developing brain that fail to connect to other cells also program themselves to die—more evidence of the life-saving need for connection; no cell thrives alone. What we see in the microcosm is reflected in the larger organism: just as our cells need to stay connected to stay alive, we, too, need regular contact with family, friends, and community. Personal relationships nourish our cells,

James Tour is a leading origin-of-life researcher with over 630 research publications and over 120 patents. He was inducted into the National Academy of Inventors in 2015, listed in “The World’s Most Influential Scientific Minds” by Thomson Reuters in 2014, and named “Scientist of the Year” by R&D Magazine. Here is how he recently described the state of the field: We have no idea how the molecules that compose living systems could have been devised such that they would work in concert to fulfill biology’s functions. We have no idea how the basic set of molecules, carbohydrates, nucleic acids, lipids and proteins were made and how they could have coupled in proper sequences, and then transformed into the ordered assemblies until there was the construction of a complex biological system, and eventually to that first cell. Nobody has any idea on how this was done when using our commonly understood mechanisms of chemical science. Those that say that they understand are generally wholly uninformed regarding chemical synthesis. Those that say, “Oh this is well worked out,” they know nothing—nothing—about chemical synthesis—nothing. … From a synthetic chemical perspective, neither I nor any of my colleagues can fathom a prebiotic molecular route to construction of a complex system. We cannot even figure out the prebiotic routes to the basic building blocks of life: carbohydrates, nucleic acids, lipids, and proteins. Chemists are collectively bewildered. Hence I say that no chemist understands prebiotic synthesis of the requisite building blocks, let alone assembly into a complex system. That’s how clueless we are. I have asked all of my colleagues—National Academy members, Nobel Prize winners—I sit with them in offices. Nobody understands this. So if your professors say it’s all worked out, if your teachers say it’s all worked out, they don’t know what they’re talking about.23

The Western medical model — and I don't mean the science of it, I mean the practice of it, because the science is completely at odds with the practice — makes two devastating separations. First of all we separate the mind from the body, we separate the emotions from the physiology. So we don't see how the physiology of people reflects their lifelong emotional experience. So we separate the mind from the body, which is not something that traditional medicine has done, I mean, Ayuverdic or Chinese medicine or shamanic tribal cultures and medicinal practices throughout the world have always recognized that mind and body are inseparable. They intuitively knew it. Many Western practitioners have known this and even taught it, but in practice we ignore it. And then we separate the individual from the environment. The studies are clear, for example, that when people are emotionally isolated they tend to get sick more quickly and they succumb more rapidly to their disease. Why? Because people's physiology is completely related to their psychological, social environment and when people are isolated and alone their stress levels are much higher because there's nothing there to help them moderate their stress. And physiologically it is straightforward, you know, it takes a five-year-old kid to understand it. However because in practice we separate them... when somebody shows up with an inflamed joint, all we do is we give them an anti-inflammatory or because the immune system is hyperactive and is attacking them we give them a medication to suppress their immune system or we give them a stress hormone like cortisol or one of its analogues, to suppress the inflammation. But we never ask: "What does this manifest about your life?", "What does this say about your relationships?", "How stressful is your job?", "To what extent do you lack control in your life?", "Where are you not authentic?", "How are you trying to work so hard to meet your attachment needs by suppressing yourself?" (because that is what you learn to do as a kid). Then we do all this research that has to do with cell biology, so we keep looking for the cause of cancer in the cell. Now there's a wonderful quote in the New York Times a couple of years ago they did a series on cancer and somebody said: "Looking for the cause of cancer inside the individual cell is like trying to understand a traffic jam by studying the internal combustion engine." We will never understand it, but we spend hundreds of billions of dollars a year looking for the cause of cancer inside the cell, not recognizing that the cell exists in interaction with the environment and that the genes are modulated by the environment, they are turned on and off by the environment. So the impact of not understanding the unity of emotions and physiology on one hand and in the other hand the relationship between the individual and the environment.. in other words.. having a strictly biological model as opposed to what has been called a bio-psycho-social, that recognizes that the biology is important, but it also reflects our psychological and social relationships. And therefore trying to understand the biology in isolation from the psychological and social environment is futile. The result is that we are treating people purely through pharmaceuticals or physical interventions, greatly to the profit of companies that manufacture pharmaceuticals and which fund the research, but it leaves us very much in the dark about a) the causes and b) the treatment, the holistic treatment of most conditions. So that for all our amazing interventions and technological marvels, we are still far short of doing what we could do, were we more mindful of that unity. So the consequences are devastating economically, they are devastating emotionally, they are devastating medically.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

This, in turn, has given us a “unified theory of aging” that brings the various strands of research into a single, coherent tapestry. Scientists now know what aging is. It is the accumulation of errors at the genetic and cellular level. These errors can build up in various ways. For example, metabolism creates free radicals and oxidation, which damage the delicate molecular machinery of our cells, causing them to age; errors can build up in the form of “junk” molecular debris accumulating inside and outside the cells. The buildup of these genetic errors is a by-product of the second law of thermodynamics: total entropy (that is, chaos) always increases. This is why rusting, rotting, decaying, etc., are universal features of life. The second law is inescapable. Everything, from the flowers in the field to our bodies and even the universe itself, is doomed to wither and die. But there is a small but important loophole in the second law that states total entropy always increases. This means that you can actually reduce entropy in one place and reverse aging, as long as you increase entropy somewhere else. So it’s possible to get younger, at the expense of wreaking havoc elsewhere. (This was alluded to in Oscar Wilde’s famous novel The Picture of Dorian Gray. Mr. Gray was mysteriously eternally young. But his secret was the painting of himself that aged horribly. So the total amount of aging still increased.) The principle of entropy can also be seen by looking behind a refrigerator. Inside the refrigerator, entropy decreases as the temperature drops. But to lower the entropy, you have to have a motor, which increases the heat generated behind the refrigerator, increasing the entropy outside the machine. That is why refrigerators are always hot in the back. As Nobel laureate Richard Feynman once said, “There is nothing in biology yet found that indicates the inevitability of death. This suggests to me that it is not at all inevitable and that it is only a matter of time before biologists discover what it is that is causing us the trouble and that this terrible universal disease or temporariness of the human’s body will be cured.

A virus particle is a very small capsule made of proteins locked together in a mathematical pattern. The pattern of the interlocking proteins in a virus is far more complicated than a snowflake. The protein capsule is sometimes wrapped in an oily membrane. Inside the capsule there is a small amount of DNA or RNA, the molecules that contain the genetic code of the virus. The genetic code is the virus’s operating system, or wetware, the complete set of instructions for the virus to make copies of itself. Unlike a snowflake or any other kind of crystal, a virus is able to re-create its form. It would be as if a single snowflake started copying itself as it falls, and those copies of the snowflake copy themselves, creating ever-growing numbers of identical copies of the first snowflake, until the air is filled with falling snow, and each flake is a perfect replica of the first flake. Many virologists feel that viruses are not truly living things. At the same time, viruses are obviously not dead. Virologists like to describe them as life forms. The term is a contradiction: How can something be a form of life that isn’t alive? Viruses carry on their existence in a misty borderland that lies between life and death, a gray zone where the things we encounter are neither provably alive nor certainly dead. One way to understand viruses is to think about them as biological machines. A virus is a wet nanomachine, a tiny, complicated, slightly fuzzy mechanism, which is rubbery, flexible, wobbly, and often a little bit imprecise in its operation—a microscopic nugget of squishy parts. Viruses are subtle, logical, tricky, reactive, devious, opportunistic. They are constantly evolving, their forms steadily changing as time passes. Like all kinds of life, viruses possess a relentless drive to reproduce themselves so that they can persist through time. When a virus starts copying itself strongly and rapidly in a host, the process is called virus amplification. As a virus amplifies itself in its host, the host, a living organism, can be destroyed. Viruses are the undead of the living world, the zombies of deep time. Nobody knows the origin of viruses—how they came into existence or when they appeared in the history of life on earth. Viruses may be examples or relics of life forms that operated at the dawn of life. Viruses may have come into existence with the first stirrings of life on the planet, roughly four billion years ago. Or they may have arisen after life started, during the time when single-celled bacteria had already come into existence—nobody knows.

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns. In effect this etches a memory of what the organism was doing or experiencing into its cells—a crucial first step for any Lamarck-like inheritance. Unfortunately, bad experiences can be etched into cells as easily as good experiences. Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be. Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains. As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse. These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic. Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves. The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways. Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes. These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli. Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout. But epigenetic changes are de facto mutations; genes might as well not function. And just like mutations, epigenetic changes live on in cells and their descendants. Indeed, each of us accumulates more and more unique epigenetic changes as we age. This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year. It also means that that detective-story trope of one twin committing a murder and both getting away with it—because DNA tests can’t tell them apart—might not hold up forever. Their epigenomes could condemn them. Of course, all this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance. Normally when sperm and egg unite, embryos erase this epigenetic information—allowing you to become you, unencumbered by what your parents did. But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children—close enough to bona fide Lamarckism to make Cuvier and Darwin grind their molars.

In physical terms, we know that every human action can be reduced to a series of impersonal events: Genes are transcribed, neurotransmitters bind to their receptors, muscle fibers contract, and John Doe pulls the trigger on his gun. But for our commonsense notions of human agency and morality to hold, it seems that our actions cannot be merely lawful products of our biology, our conditioning, or anything else that might lead others to predict them. Consequently, some scientists and philosophers hope that chance or quantum uncertainty can make room for free will. For instance, the biologist Martin Heisenberg has observed that certain processes in the brain, such as the opening and closing of ion channels and the release of synaptic vesicles, occur at random, and cannot therefore be determined by environmental stimuli. Thus, much of our behavior can be considered truly “self-generated”—and therein, he imagines, lies a basis for human freedom. But how do events of this kind justify the feeling of free will? “Self-generated” in this sense means only that certain events originate in the brain. If my decision to have a second cup of coffee this morning was due to a random release of neurotransmitters, how could the indeterminacy of the initiating event count as the free exercise of my will? Chance occurrences are by definition ones for which I can claim no responsibility. And if certain of my behaviors are truly the result of chance, they should be surprising even to me. How would neurological ambushes of this kind make me free? Imagine what your life would be like if all your actions, intentions, beliefs, and desires were randomly “self-generated” in this way. You would scarcely seem to have a mind at all. You would live as one blown about by an internal wind. Actions, intentions, beliefs, and desires can exist only in a system that is significantly constrained by patterns of behavior and the laws of stimulus-response. The possibility of reasoning with other human beings—or, indeed, of finding their behaviors and utterances comprehensible at all—depends on the assumption that their thoughts and actions will obediently ride the rails of a shared reality. This is true as well when attempting to understand one’s own behavior. In the limit, Heisenberg’s “self-generated” mental events would preclude the existence of any mind at all. The indeterminacy specific to quantum mechanics offers no foothold: If my brain is a quantum computer, the brain of a fly is likely to be a quantum computer, too. Do flies enjoy free will? Quantum effects are unlikely to be biologically salient in any case. They play a role in evolution because cosmic rays and other high-energy particles cause point mutations in DNA (and the behavior of such particles passing through the nucleus of a cell is governed by the laws of quantum mechanics). Evolution, therefore, seems unpredictable in principle.13 But few neuroscientists view the brain as a quantum computer. And even if it were, quantum indeterminacy does nothing to make the concept of free will scientifically intelligible. In the face of any real independence from prior events, every thought and action would seem to merit the statement “I don’t know what came over me.” If determinism is true, the future is set—and this includes all our future states of mind and our subsequent behavior. And to the extent that the law of cause and effect is subject to indeterminism—quantum or otherwise—we can take no credit for what happens. There is no combination of these truths that seems compatible with the popular notion of free will.