Against Obese Quotes

The obesity pandemic is due to our altered biochemistry, which is a result of our altered environment.

Coffee, even the decaffeinated version, appears to protect against type 2 diabetes. In a 2009 review, each additional daily cup of coffee lowered the risk of diabetes by 7 percent, even up to six cups per day.23

Exercise is the single best thing you can do for yourself. It’s way more important than dieting, and easier to do. Exercise works at so many levels—except one: your weight.

The marijuana paradox - although associated with increased appetite and calorie consumption, regular use of cannabis, protects against diabetes and obesity. How it manages to do so, however, is still anybody's guess!

Politics is the entertainment branch of industry.” —Frank Zappa

The Japanese have a saying, “Eat until you are 80 percent full.

The real problem is not in losing the weight but in keeping it off for any meaningful length of time. Numerous sources show that almost every lifestyle intervention works for the first three to six months. But then the weight comes rolling back.

Sugar is now the most ubiquitous foodstuff worldwide, and has been added to virtually every processed food, limiting consumer choice and the ability to avoid it. Approximately 80 percent of the 600,000 consumer packaged foods in the United States have added caloric sweeteners.

Unfortunately, food now matters even more than it should. Food is beyond a necessity; it’s also a commodity, and it has been reformulated to be an addictive substance. This has many effects on our world: economically, politically, socially, and medically. There

Food processing is the Mr. Hyde of this obesity pandemic. And the way to reverse it is to do the opposite.

Fat cells want to be downsized about as much as General Motors or AIG.

In other words, the FDA is concerned only with acute toxins in food (those chemicals that kill you immediately), not chronic toxins, which kill you slowly by promoting chronic disease.

As every close observer of the deadlocks arising from the political correctness knows, the separation of legal justice from moral Goodness –which should be relativized and historicized- ends up in an oppressive moralism brimming with resentment. Without any “organic” social substance grounding the standards of what Orwell approvingly called “common decency” (all such standards having been dismissed as subordinating individual freedoms to proto-Fascist social forms), the minimalist program of laws intended simply to prevent individuals from encroaching upon one another (annoying or “harassing” each other) turns into an explosion of legal and moral rules, an endless process (a “spurious infinity” in Hegel’s sense) of legalization and moralization, known as “the fight against all forms of discrimination.” If there are no shared mores in place to influence the law, only the basic fact of subjects “harassing other subjects, who-in the absence of mores- is to decide what counts as “harassment”? In France, there are associations of obese people demanding all the public campaigns against obesity and in favor of healthy eating be stopped, since they damage the self-esteem of obese persons. The militants of Veggie Pride condemn the speciesism” of meat-eaters (who discriminate against animals, privileging the human animal-for them, a particularly disgusting form of “fascism”) and demand that “vegeto-phobia” should be treated as a kind of xenophobia and proclaimed a crime. And we could extend the list to include those fighting for the right of incest marriage, consensual murder, cannibalism . . . The problem here is the obvious arbitrariness of the ever-new rule. Take child sexuality, for example: one could argue that its criminalization is an unwarranted discrimination, but one could also argue that children should be protected from sexual molestation by adults. And we could go on: the same people who advocate the legalization of soft drugs usually support the prohibition of smoking in public places; the same people who protest the patriarchal abuse of small children in our societies worry when someone condemns a member of certain minority cultures for doing exactly this (say, the Roma preventing their children from attending public schools), claiming that this is a case od meddling with other “ways of life”. It is thus for necessary structural reasons that the “fight against discrimination” is an endless process which interminably postpones its final point: namely a society freed from all moral prejudices which, as Michea puts it, “would be on this very account a society condemned to see crimes everywhere.

If, in recommending that Americans avoid meat, cheese, milk, cream, butter, eggs, and the rest, it turns out that nutrition experts made a mistake, it will have been a monumental one. Measured just by death and disease, and not including the millions of lives derailed by excess weight and obesity, it’s very possible that the course of nutrition advice over the past sixty years has taken an unparalleled toll on human history. It now appears that since 1961, the entire American population has, indeed, been subjected to a mass experiment, and the results have clearly been a failure. Every reliable indicator of good health is worsened by a low-fat diet. Whereas diets high in fat have been shown, again and again, in a large body of clinical trials, to lead to improved measures for heart disease, blood pressure, and diabetes, and are better for weight loss. Moreover, it’s clear that the original case against saturated fats was based on faulty evidence and has, over the last decade, fallen apart. Despite more than two billion dollars in public money spent trying to prove that lowering saturated fat will prevent heart attacks, the diet-heart hypothesis has not held up.

Without a doubt, what the war on obesity has created the most of is stigma. It has turned fatness into the ultimate moral sin and given the public a medically motivated reason to bully, harass, and discriminate against someone based on their size.

As you will see, all successful diets share three precepts: low sugar, high fiber (which means high micronutrients), and fat and carbohydrate consumed together in the presence of an offsetting amount of fiber. Anything after that is window dressing.

I feel my hand. I am these two beasts struggling at the end of my arms. My hand scratches one of its paws with the nail of the other paw; I feel its weight on the table which is not me. It's long, long, this impression of weight, it doesn't pass. There is no reason for it to pass. It becomes intolerable ... I draw back my hand and put it in my pocket; but immediately I feel the warmth of my thigh through the stuff. I pull my hand out of my pocket and let it hang against the back of the chair. Now I feel a weight at the end of my arm. It pulls a little, softly, insinuatingly it exists. I don't insist: no matter where I put it it will go on existing; I can't suppress it, nor can I suppress the rest of my body, the sweaty warmth, which soils my shirt, nor all this warm obesity which turns lazily, as if someone were stirring it with a spoon, nor all the sensations going on inside, going, coming, mounting from my side to my armpit or quietly vegetating from morning to night, in their usual corner.

The American food industry produces 3,900 calories per person per day, with about 29 percent wastage, but we should rationally eat 1,800–2,000. Who eats the difference? We do! Throughout evolution, humans could eat only a fixed amount, but today that amount is limitless.

We have nothing against playing video games; they have many good features and benefits. Our concern is that when they are played to excess, especially in social isolation, they can hinder a young man's ability and interest in developing his face-to-face social skills. Multiple problems, including obesity, violence, anxiety, lower school performance, social phobia and shyness, greater impulsivity and depression, have all been associated with excessive gaming. The variety and intensity of video game action makes other parts of life, like school, seem comparatively boring, and that creates a problem with their academic performance, which in turn might require medication to deal with attention deficit hyperactivity disorder (ADHD), which then leads to other problems down the road in a disastrous negative cycle...

THE RELIABLE WAY OUT OF OBESITY IS VIA PERSONAL RESPONSIBILITY. This point has been lost on the hundreds of folks who have railed against my arguments for food addiction in periodicals, so I"m eager to make it here: No one but me put the food in my mouth. Even if I had grown up imprisoned in a crawl space under the basement stairs (I wasn't), even if tragedy has befallen me every 15 minutes since (it hasn't), I"m still responsible for what I eat. If my food is out of control (it was), then I'm responsible for finding, requesting, and accepting the help I need.

For instance, have you ever been going about your business, enjoying your life, when all of sudden you made a stupid choice or series of small choices that ultimately sabotaged your hard work and momentum, all for no apparent reason? You didn’t intend to sabotage yourself, but by not thinking about your decisions—weighing the risks and potential outcomes—you found yourself facing unintended consequences. Nobody intends to become obese, go through bankruptcy, or get a divorce, but often (if not always) those consequences are the result of a series of small, poor choices. Elephants Don’t Bite Have you ever been bitten by an elephant? How about a mosquito? It’s the little things in life that will bite you. Occasionally, we see big mistakes threaten to destroy a career or reputation in an instant—the famous comedian who rants racial slurs during a stand-up routine, the drunken anti-Semitic antics of a once-celebrated humanitarian, the anti-gay-rights senator caught soliciting gay sex in a restroom, the admired female tennis player who uncharacteristically threatens an official with a tirade of expletives. Clearly, these types of poor choices have major repercussions. But even if you’ve pulled such a whopper in your past, it’s not extraordinary massive steps backward or the tragic single moments that we’re concerned with here. For most of us, it’s the frequent, small, and seemingly inconsequential choices that are of grave concern. I’m talking about the decisions you think don’t make any difference at all. It’s the little things that inevitably and predictably derail your success. Whether they’re bone-headed maneuvers, no-biggie behaviors, or are disguised as positive choices (those are especially insidious), these seemingly insignificant decisions can completely throw you off course because you’re not mindful of them. You get overwhelmed, space out, and are unaware of the little actions that take you way off course. The Compound Effect works, all right. It always works, remember? But in this case it works against you because you’re doing… you’re sleepwalking.

No, my friends, this won’t be solved from the top-down. This will have to be a bottom-up movement. You can’t expect government to do the right thing. You have to coerce it into doing the right thing. When there are more votes at stake than dollars, that’s when legislators will come around. But that’s not a reason to be daunted. In a democracy, the public has power.

Barry Popkin of the University of North Carolina states that of the six hundred thousand food items for sale in the United States, 80 percent are laced with added sugar. Ninety percent of the food produced in the United States is sold to you by a total of ten conglomerates—Coca-Cola, ConAgra, Dole, General Mills, Hormel, Kraft, Nestle, Pepsico, Procter and Gamble, and Unilever.

Michael Pollan, in his New York Times article “Unhappy Meals,” exhorts us to “Eat food. Not too much. Mostly plants.” That’s seven words; I’ll reduce it to three: eat real food. The “not too much” will take care of itself. And the “mostly plants” isn’t a worry if you eat the plants as they came out of the ground, or the animals who ate the food that came out of the ground—because they ate plants.

By specifying energy or caloric content as the instrument through which foods influence body weight, it implies that a calorie of sugar would be no more or less capable of causing obesity, and thus diabetes, than a calorie of broccoli or olive oil or eggs or any other food. By the 1960s, the phrase “a calorie is a calorie” had become a mantra of the nutrition-and-obesity research community, and it was invoked to make just this argument (as it still is).

Everyone knows that the environments we created to satisfy our wishes for sweets, salt, fat and leisure have resulted in epidemics of chronic disease. Obesity and eating disorders are prime examples, but alcoholism and drug addiction are also made possible by ready access to substances and means of administration that have only recently become available. Lack of selection until recent times against these often fatal disorders is an essential part of any evolutionary explanation.

The question is, why is the USDA in charge of the country’s nutrition anyway? In 2003 the Chicago Tribune reported the comments of Senator Peter Fitzgerald (R-Ill.)15: “The primary mission of the USDA is, after all, to promote the sale of agricultural products…So putting the USDA in charge of dietary advice is in some respects like putting the fox in charge of the henhouse.” So who should be in charge of our nutrition? How about anyone without a vested interest in pushing the poison?

One of our greatest epidemics today is obesity. It is estimated that more than 500 million people suffer from obesity worldwide today, and that it kills more than three million people each year. In comparison, about 55,000 people are killed in war each year, which of course in no way suggests that we are overestimating the horror and seriousness of war – how could we? – but the little attention we give to obesity in comparison does suggest, however, that we are not taking the “war” we should be waging against obesity seriously. It seems that we overlook what a merciless killer and cause of pain that obesity and the overeating that leads to it really is: it increases the risk of heart disease (the most common cause of death worldwide), many kinds of cancer, type 2 diabetes, degenerative joint disease and mental problems such as depression and low self-esteem.[27] Fortunately, a lot seems to imply that we have a powerful and peaceful weapon at our hands that can help us overcome obesity: a vegan diet.

About 74 percent of U.S. adults are overweight or obese, and 93.2 percent have metabolic dysfunction. These numbers sound high until you realize how many levers of modern society are stacked against our mitochondria and metabolism: too much sugar, too much stress, too much sitting, too much pollution, too many pills, too many pesticides, too many screens, too little sleep, and too little micronutrients. These trends—with trillions of dollars behind them—are causing epidemic levels of mitochondrial dysfunction and underpowered, sick, inflamed bodies.

The strongest evidence yet was published in 2010. In a painstaking long-term study, much larger and more thorough than anything done previously, an international team of researchers tracked one thousand children in New Zealand from birth until the age of thirty-two. Each child’s self-control was rated in a variety of ways (through observations by researchers as well as in reports of problems from parents, teachers, and the children themselves). This produced an especially reliable measure of children’s self-control, and the researchers were able to check it against an extraordinarily wide array of outcomes through adolescence and into adulthood. The children with high self-control grew up into adults who had better physical health, including lower rates of obesity, fewer sexually transmitted diseases, and even healthier teeth. (Apparently, good self-control includes brushing and flossing.) Self-control was irrelevant to adult depression, but its lack made people more prone to alcohol and drug problems. The children with poor self-control tended to wind up poorer financially. They worked in relatively low-paying jobs, had little money in the bank, and were less likely to own a home or have money set aside for retirement. They also grew up to have more children being raised in single-parent households, presumably because they had a harder time adapting to the discipline required for a long-term relationship. The children with good self-control were much more likely to wind up in a stable marriage and raise children in a two-parent home. Last, but certainly not least, the children with poor self-control were more likely to end up in prison. Among those with the lowest levels of self-control, more than 40 percent had a criminal conviction by the age of thirty-two, compared with just 12 percent of the people who had been toward the high end of the self-control distribution in their youth.

After a series of promotions—store manager at twenty-two, regional manager at twenty-four, director at twenty-seven—I was a fast-track career man, a personage of sorts. If I worked really hard, and if everything happened exactly like it was supposed to, then I could be a vice president by thirty-two, a senior vice president by thirty-five or forty, and a C-level executive—CFO, COO, CEO—by forty-five or fifty, followed of course by the golden parachute. I’d have it made then! I’d just have to be miserable for a few more years, to drudge through the corporate politics and bureaucracy I knew so well. Just keep climbing and don't look down. Misery, of course, encourages others to pull up a chair and stay a while. And so, five years ago, I convinced my best friend Ryan to join me on the ladder, even showed him the first rung. The ascent is exhilarating to rookies. They see limitless potential and endless possibilities, allured by the promise of bigger paychecks and sophisticated titles. What’s not to like? He too climbed the ladder, maneuvering each step with lapidary precision, becoming one of the top salespeople—and later, top sales managers—in the entire company.10 And now here we are, submerged in fluorescent light, young and ostensibly successful. A few years ago, a mentor of mine, a successful businessman named Karl, said to me, “You shouldn’t ask a man who earns twenty thousand dollars a year how to make a hundred thousand.” Perhaps this apothegm holds true for discontented men and happiness, as well. All these guys I emulate—the men I most want to be like, the VPs and executives—aren’t happy. In fact, they’re miserable.  Don’t get me wrong, they aren’t bad people, but their careers have changed them, altered them physically and emotionally: they explode with anger over insignificant inconveniences; they are overweight and out of shape; they scowl with furrowed brows and complain constantly as if the world is conspiring against them, or they feign sham optimism which fools no one; they are on their second or third or fourth(!) marriages; and they almost all seem lonely. Utterly alone in a sea of yes-men and women. Don’t even get me started on their health issues.  I’m talking serious health issues: obesity, gout, cancer, heart attacks, high blood pressure, you name it. These guys are plagued with every ailment associated with stress and anxiety. Some even wear it as a morbid badge of honor, as if it’s noble or courageous or something. A coworker, a good friend of mine on a similar trajectory, recently had his first heart attack—at age thirty.  But I’m the exception, right?

The second development, in 1960, was the development of a new technology that allowed researchers for the first time ever to measure accurately the level of hormones circulating in the bloodstream. It was the invention of Rosalyn Yalow, a medical physicist, and Solomon Berson, a physician, and was called the radioimmunoassay. When Yalow won the Nobel Prize for the work in 1977 (Berson by then was not alive to share it), the Nobel Foundation would describe it aptly as bringing about “a revolution in biological and medical research.” Those interested in obesity could now finally answer the questions about which the pre–World War II European clinicians could only speculate: which hormones were regulating the storage of fat in fat cells and its use for fuel by the rest of the body? Answers began coming with the very first publications out of Yalow and Berson’s laboratory and were swiftly confirmed by others. As it turns out, virtually all hormones work to mobilize fat from fat cells so that it can then be used for fuel. Hormones are signaling our bodies to act—flee or fight, reproduce, grow—and they also signal the fat cells to make available the fuel necessary for these actions. The one dominant exception to this fuel-mobilization signaling is insulin, the same hormone that researchers still assumed in the early 1960s to be deficient in all cases of diabetes. Insulin, Yalow and Berson reported, can be thought of as orchestrating how the body uses or “partitions” the fuel it takes in.

Ethanol (Grain Alcohol) Ethanol is a naturally occurring by-product of carbohydrate metabolism, called fermentation. Upon ingestion of 120 calories of ethanol (e.g., a 1.5-ounce shot of 80-proof hard spirits), 10 percent (12 calories) is metabolized within the stomach and intestine (called the first-pass effect) and 10 percent is metabolized by the brain and other organs. The metabolism in the brain is what leads to the alcohol’s intoxicating effects. Approximately 96 calories reach the liver—four times more than with glucose. And that’s important, as the detrimental effects are dose-dependent.

When a person is exposed to cold, his body is stimulated to produce these brown fats. This is a result of the body trying to keep warm by increasing heat production through cell metabolism. More brown fats and improved metabolism means a faster and more efficient way of losing weight and keeping it off. The increased levels of brown fats in the body help to retard the signs of aging and help to fight against obesity, diabetes, and heart disease.

a 2014 meta-analysis (a compilation of many similar studies) showing that vegetarian diets may be particularly good at lowering blood pressure.110 And the more plants, perhaps, the better. Meat-free diets in general “confer protection against cardiovascular diseases . . . some cancers and total mortality,” but completely plant-based diets “seem to offer additional protection for obesity, hypertension, type-2 diabetes, and cardiovascular mortality.”111

FOREWORD When Commander Perry opened up to the occidental world that shut-tight little island Kingdom, Japan, he did more than merely contact for our manufacturers a people who bought "Nifty Clothes," with two pair of pants. He gave us an insight into a world that was thoroughly organized and civilized long before Columbus discovered West where the East should have been. The Japanese learned much from the so-called civilized world, -but they taught us something we could never have learned from intercourse with any other nation. They gave our governmental forces of law and order a weapon that aided materially in the suppression of disorderly elements throughout our great cities. It took time, of course, to break down the prejudices that our early enforcement officers, in common with our then wild and wooly population, had against anything that was foreign. But when the great police forces of our largest metropolises realized that guns and billies alone would not be proof against big, burly lawbreakers, and that to instil respect in the hearts of "bruisers" they needed something other than armaments—pistols that could not be drawn fast enough,—they then discovered the wonder of Jiu-jitsu. They found that the wily little brown man depended on brain instead of brawn and that he had developed a Science and an Art that utilized another's strength to his own undoing. Strangely enough it was the layman who first appreciated the potential value of Jiu-jitsu. For many years before the Police Forces of our cities put a study of this Science into the training of every rookie policeman, there were physical culture experts in America who advocated the use of it by everyone who had any respect for physical prowess but who found the spirit more willing than the flesh. They showed that it needed no possession of unusual strength to overcome an opponent that depended entirely on his bulk and ferocious appearance to cow the meeker ones of the earth into submission. The Japanese, by the very fact of their small stature, are compelled to place more emphasis on strategy than on force. Thus they have thoroughly developed Jiu-jitsu and there is barely a saffron-hued tot in Japan that doesn't know something about the "Gentle-Art" as it is known. President Masaryk of Czechoslovakia, one of the world's greatest educators, who, together with millions of his enlightened and progressive countrymen, is a firm believer in "a strong mind in a strong body," sought to teach every schoolboy in his country some knowledge of the wisest of all physical sciences. While it does not itself develop and build muscle, it is an invaluable aid to the sensible use of the body. It is a form of wrestling that combines the cunning of the fox with the lithe grace and agility of the panther. It sharpens the brain and quickens the nerve centers. The man or woman who has self-respect must not sit by and permit our people to become a nation of spectators watching athletic specialists perform, while we become obese and ungainly applauders. Jiu-jitsu gives the man, woman and child, denied by nature a great frame, the opportunity to walk without fear, to resist successfully the bullies of their particular world, and the self-confidence which only a "well-armed" athlete can have. By its use, differences in weight, height and reach are practically wiped out, so that he who knows, may smilingly face superior odds and conquer.

As if to confirm the difference between Korean and European anti-Americanism, Salman Rushdie sees parallel patterns in the difference between the anti-Americanism of the Muslim and European worlds. The former, according to Rushdie, chiefly enlists political reasons for its antipathy to America, but the latter is anti-American in its essence and entire behavior: These days there seem to be as many of these accusers outside the Muslim world as inside it. Anybody who has visited Britain and Europe, or followed the public conversation there during the past five months, will have been struck, even shocked, by the depth of antiAmerican feeling among large segments of the population. Western anti-Americanism is an altogether more petulant phenomenon than its Islamic counterpart and far more personalized. Muslim countries don’t like America’s power, its “arrogance,” its success; but in the nonAmerican West, the main objection seems to be to American people. Night after night, I have found myself listening to Londoners’ diatribes against the sheer weirdness of the American citizenry. The attacks on America are routinely discounted. . . . American patriotism, obesity, emotionality, self-centeredness: these are the crucial issues.”37

Coffee drinking is associated with a 10 per cent to 15 per cent reduction in total mortality.26 Large-scale studies27 found that most major causes of death, including heart disease, were reduced. Coffee may guard against the neurologic diseases Alzheimer’s,28, 29 Parkinson’s disease,30, 31 liver cirrhosis32 and liver cancer.33 A word of caution here: While these correlation studies are suggestive, they are not proof of benefit. However, they suggest that coffee may not be as harmful as we imagined.

AN INSULINOMA IS a rare tumor3, 4 that secretes abnormally large amounts of insulin in the absence of any other significant disease. As the patient’s insulin levels increase, his or her levels of insulin resistance increase in lock step—a protective mechanism and a very good thing. If insulin resistance did not develop, the high insulin levels would rapidly lead to very, very low blood sugars. The resulting severe hypoglycemia would quickly lead to seizures and death. Since the body doesn’t want to die (and neither do we), it protects itself by developing insulin resistance—demonstrating homeostasis. The resistance develops naturally to shield against the unusually large insulin levels. Insulin causes insulin resistance.

The fundamental biological principle at work here is homeostasis. There appears to be a ‘set point’ for body weight and fatness, as first proposed in 1984 by Keesey and Corbett.9 Homeostatic mechanisms defend this body set weight against changes, both up and down. If weight drops below body set weight, compensatory mechanisms activate to raise it. If weight goes above body set weight, compensatory mechanisms activate to lower it. The problem in obesity is that the set point is too high.

STEP 5: INCREASE YOUR CONSUMPTION OF PROTECTIVE FACTORS FIBER CAN REDUCE the insulin-stimulating effects of carbohydrates, making it one of the main protective factors against obesity, but the average North American diet falls far short of recommended daily intakes. (For more on fiber as a protective factor, see chapter 16.) Numerous studies and observations have confirmed the weight-lowering effects of dietary fiber. Natural whole foods contain plenty of fiber, which is often removed during processing. Fruits, berries, vegetables, whole grains, flax seeds, chia seeds, beans, popcorn, nuts, oatmeal and pumpkin seeds provide ample fiber.

In Canada, an estimated one in three people lives with at least one chronic disease. Conditions that appeared to increase the risk and severity of COVID-19 included type 2 diabetes, obesity, high blood pressure and other heart conditions, chronic obstructive pulmonary disease (COPD), chronic kidney disease and cancer. All of these conditions have been shown to be associated with inadequate diets and malnutrition, either as a cause or consequence of the disease. We normally associate the word "malnutrition" with undernutrition or starvation. However, malnutrition also applies to overconsumption of calories, protein or fat and frequently results in overweight or obesity. A well-primed immune response depends on good nutrition to function, and malnutrition is known to increase susceptibility to infections. In turn, infection can aggravate malnutrition, since it increases the body's demand for nutrients. This creates a vicious cycle, further increasing vulnerability to infection. In Canada, malnutrition is much more widespread than we would like to believe. A cross-Canada study conducted in eighteen hospitals screened patients for malnutrition on admission and found 45 per cent of them to be malnourished. Those who were malnourished had significantly longer hospital stays than those who were not.

I don’t care about any of this shit,” he muttered against her apple shampoo-smelling hair. “All I care about is right here in my arms and outside attempting to play catch with a morbidly obese dog.

To explore how physical activity helps but doesn’t entirely prevent cardiovascular diseases, let’s return to the trinity of intertwined factors that are the root causes of the problem: high cholesterol, high blood pressure, and inflammation. Cholesterol. A cholesterol test usually measures the levels of three molecules in your blood. The first is low-density lipoprotein (LDL), often termed bad cholesterol. Your liver produces these balloon-like molecules to transport fats and cholesterol throughout your bloodstream, but some LDLs have a harmful tendency to burrow into the walls of arteries, especially when blood pressure is high. These intrusions cause an inflammatory reaction that generates plaques. The second type of cholesterol is high-density lipoprotein (HDL), sometimes called good cholesterol, because these molecules scavenge and return LDLs back to the liver. The third type are triglycerides, fat molecules that are floating freely in the bloodstream and a signpost for metabolic syndrome. To make a long story short, diets rich in sugar and saturated fats contribute to cardiovascular disease because they promote high levels of plaque-forming LDLs. Conversely, physical activity helps prevent cardiovascular disease by lowering triglycerides, raising HDL levels, and to a lesser degree lowering LDL. Blood pressure. A blood pressure test gives you two readings: the higher (systolic) number is the pressure your heart’s main chamber overcomes when it squeezes blood throughout your body; the lower (diastolic) number is the pressure your heart experiences as its main chamber fills with blood. By convention high blood pressure is a reading greater than 130/90 or 140/90. Blood pressures above these values are concerning because, unabated, they damage the walls of arteries, making them vulnerable to invasion by plaque-inducing LDLs. As we already saw, once plaques start to form, blood pressure can rise, potentially stimulating yet more plaques. Chronically high blood pressure also strains the heart, causing it to thicken abnormally and weaken. By forcing more blood to flow more rapidly through arteries, physical activity stimulates the generation of new arteries throughout the body and helps keep existing arteries supple, protecting against high blood pressure. Inflammation. Plaques don’t form out of the blue but instead occur when white blood cells in the bloodstream react to the inflammation caused by LDLs and high blood pressure. Chronic inflammation also increases one’s likelihood of developing plaques from high cholesterol and blood pressure.40 And, as we have previously seen, while inflammation is caused by factors such as obesity, junky diets, excess alcohol, and smoking, it is substantially lowered by physical activity.

specifying energy or caloric content as the instrument through which foods influence body weight, it implies that a calorie of sugar would be no more or less capable of causing obesity, and thus diabetes, than a calorie of broccoli or olive oil or eggs or any other food. By the 1960s, the phrase “a calorie is a calorie” had become a mantra of the nutrition-and-obesity research community, and it was invoked to make just this argument (as it still is).

Bottom line, although lots of effort and money have been thrown at various methods of obesity prevention at the individual education level, the results are downright disappointing.18 When it comes right down to it, you can’t change behavior with information alone, especially when you’re talking about addictive substances. Necessary, but not sufficient. Because the biochemical drive will eventually overcome any cognitive attempt to control it. Nope, it’s going to be all about changing the environment, and that means changing availability.

Do we need to eat what our ancestors did or eschew all carbs? I would propose that all we need to do is eat “safe carbs.” That means low sugar to prevent insulin resistance, and high fiber to reduce flux to the liver and prevent insulin hypersecretion. And while we’re at it, eat “safe fat,” that is, real fat rather than synthetic fat (such as trans fats, which can’t be metabolized).

None of the suggestions in this chapter is remotely actionable today, because government has been co-opted in what is known as “elite capture.” By this we mean that the government bends the regulatory systems in the food industry’s favor, to maintain a decidedly lopsided power structure. Either the legislative branch won’t act because the food industry is paying it off, the executive branch won’t act because it’s afraid of the political repercussions, or the populace won’t act because as far as they are concerned, “a calorie is still a calorie” and they still believe in personal responsibility—and they’re addicted anyway.

The report then provided recommendations on how we might remain cancer free. The first is to “be as lean as possible” and “to avoid weight gain and increased waist circumference through adulthood.” The second recommendation is to “be physically active as part of everyday life,” because the experts who wrote this report believe that “physical activity protects against weight gain, overweight and obesity” and by doing so protects against cancer. And the third recommendation is to “limit consumption of energy-dense foods [and] avoid sugary drinks,” because this is also thought “to prevent and control weight gain, overweight and obesity.

Coffee drinking is associated with a 10 percent to 15 percent reduction in total mortality.26 Large-scale studies27 found that most major causes of death, including heart disease were reduced. Coffee may guard against the neurologic diseases Alzheimer’s,28, 29 Parkinson’s disease,30, 31 liver cirrhosis32 and liver cancer.

When Christensenellaceae was added to human stool devoid of this group, the altered stool protected against obesity.

obesity is also associated with poverty, and even extreme poverty, and that should be a compelling argument against physical inactivity as a cause of the disease. Those who earn their living through manual labor tend to be the less advantaged members of societies in developed nations, and yet they will have the greatest obesity rates.

for all its problems in teaching other subjects, the United States is leading the pack in commercial indoctrination. The massive wave of advertising to children is considered a contributing factor in the epidemic of juvenile obesity, the growth of attention-deficit disorders, and other psychological issues, as well as the rampant sexualization of girls at ever-younger ages.

In short—insulin makes you gain weight, while cortisol tells you where to put it.

For half a century, nutrition experts have been dedicated to the hypothesis that fat, especially saturated fat, causes heart disease (plus obesity and cancer). Any evidence to the contrary has been difficult, if not impossible, for experts to acknowledge—even though there has been plenty of it. A careful look at the vast body of scientific observations about diet and health shows a surprising and unexpected picture, and one that does not seem to support a solid argument against saturated fat.

■Hormone production. Bones produce osteocalcin, a hormone which not only helps regulate bone formation, but also protects against obesity, glucose intolerance, and diabetes mellitus. (Osteocalcin is discussed further in Chapter 16.)

The 5-unit BMI difference between vegans and nonvegetarians indicates a substantial potential of vegetarianism to protect against obesity. Increased conformity to vegetarian diets protected against risk of type 2 diabetes after lifestyle characteristics and BMI were taken into account. Pesco- and semi-vegetarian diets afforded intermediate protection.

The sum of the evidence against saturated fat over the past half-century amounts to this: the early trials condemning saturated fat were unsound; the epidemiological data showed no negative association; saturated fat’s effect on LDL-cholesterol (when properly measured in subfractions) is neutral; and a significant body of clinical trials over the past decade has demonstrated the absence of any negative effect of saturated fat on heart disease, obesity, or diabetes.

Of course, even once mast cell disease is diagnosed, it can still be difficult to stabilize and reverse associated obesity simply via mast-cell-directed therapy,

Since mast cell disease can drive accumulation of fat and therefore obesity in some patients,

People under chronic stress often change their eating habits, and many of them overeat. Psychological stress elevates circulating ghrelin, which stimulates a preference for calorie-rich “comfort” foods. These foods activate reward circuits, increasing dopamine and reducing stress-induced anxiety and depression. In our laboratory, we found that a high-fat diet protects against the deleterious effects of chronic stress. This blunting effect of a high-fat diet on stress is likely mediated by the HPA axis. At some point this can move behavior from impulsive to compulsive. Like an addiction, you can become tolerant to comfort food, and no longer get the same dopamine reward. That can increase your anxiety and depression, which can lead to additional overeating. This in turn can lead to obesity, which further contributes to anxiety and depression.110

The combination of too many free radicals, oxidative stress, and glycation leads to a generalized state of inflammation in the body. Inflammation is a protective measure; it’s the result of the body trying to defend against invaders. But chronic inflammation is harmful because it turns against our own body. From the outside, you might see redness and swelling, and on the inside, tissues and organs are slowly getting damaged. Inflammation can also be driven up by alcohol, smoking, stress, leaky gut syndrome, and substances released by body fat. Chronic inflammation is the source of most chronic illnesses, such as stroke, chronic respiratory diseases, heart disorders, liver disease, obesity, and diabetes. The World Health Organization calls inflammation-based diseases “the greatest threat to human health.” Worldwide, three out of five people will die of an inflammation-based disease. The good news is, a diet that reduces glucose spikes decreases inflammation and along with it your risk of contracting any of these inflammation-based diseases.

The hypothesis addressed in this book, for instance, is that sugar is the dietary trigger of obesity and diabetes and, if so, the diseases such as heart disease that associate with them.

The sum of the evidence against saturated fat over the past half-century amounts to this: the early trials condemning saturated fat were unsound; the epidemiological data showed no negative association; saturated fat’s effect on LDL-cholesterol (when properly measured in subfractions) is neutral; and a significant body of clinical trials over the past decade has demonstrated the absence of any negative effect of saturated fat on heart disease, obesity, or diabetes. In other words, every plank in the case against saturated fat has, upon rigorous examination, crumbled away. It seems now that what sustains it is not so much science as generations of bias and habit—although, as the latest 2013 AHA-ACC guidelines show, bias and habit present powerful, if not impenetrable, barriers to change.

sexual thoughts are only the beginning of why it would be a disaster if we could read each other’s minds,” continued Hall, right on cue. “And I’m not talking about just being able to read each other’s surface thoughts, which would be bad enough, but being able to read each other’s innermost thoughts. The problem goes far beyond just reading all the white lies we tell each other dozens of times a day to spare each other’s feelings.” “Like telling your friend you like her new outfit when you actually despise it?” “Right. You could argue that these lies are at least told for the right reasons. But what I’m talking about is far worse. People wishing other people were dead. Wives learning what their husbands are really thinking about when they’re pretending to be listening to them, and vice versa. Or what their partners are thinking about during sex. Spouses learning of the sordid details of past infidelities, both real and fantasized. Subordinates who despise their bosses. You think there are any employees only pretending to laugh at the bosses’ jokes? Coworkers who badmouth colleagues behind their backs. Kids learning what their parents really think about their fifth grade art projects, and their general criticisms and disappointments. And parents reading the hatred toward them that nearly all kids feel at one time or another. And revealed prejudices, even among the best and most open-minded of us. Not necessarily just against blacks, or whites, or Asians, or homosexuals, or Arabs. But against the obese. Rednecks. Snobs. Sluts. Believe me, I’ve been reading minds. I know.

Most narratives of the movement for gay equality exalt an uprising by the patrons at a New York City bar, the martyrdom of a San Francisco city councilor, and the activism against an orange juice spokeswoman in Miami. All of these played a significant role. But the spark for the revolution was lit, and its flame was tended, in Washington, DC, by a motley procession of once-secret people beginning with a stubborn astronomer who fought back against government discrimination by appealing to the country’s founding documents; an obese albino pornographer who won for his fellow gay men the same freedom to read that their heterosexual countrymen enjoyed; the African American civil rights leader who refused to let a powerful segregationist dictate the terms of his citizenship as a man who was both Black and gay; the lesbian presidential aide so deeply closeted that she never came out yet who organized the first meeting of gay activists at the White House; and the thousands of clerks, managers, secretaries, legislative directors, technology specialists, cryptologists, speechwriters, legal counsels, librarians, and other ordinary people who chose to live their lives honestly. Like

I was struck, during COVID-19’s early months, that America’s Doctor, apparently preoccupied with his single vaccine solution, did little in the way of telling Americans how to bolster their immune response. He never took time during his daily White House briefings from March to May 2020 to instruct Americans to avoid tobacco (smoking and e-cigarettes/vaping double death rates from COVID); to get plenty of sunlight and to maintain adequate vitamin D levels (“Nearly 60 percent of patients with COVID-19 were vitamin D deficient upon hospitalization, with men in the advanced stages of COVID-19 pneumonia showing the greatest deficit”); or to diet, exercise, and lose weight (78 percent of Americans hospitalized for COVID-19 were overweight or obese). Quite the contrary, Dr. Fauci’s lockdowns caused Americans to gain an average of two pounds per month and to reduce their daily steps by 27 percent. He didn’t recommend avoiding sugar and soft drinks, processed foods, and chemical residues, all of which amplify inflammation, compromise immune response, and disrupt the gut biome which governs the immune system. During the centuries that science has fruitlessly sought remedies against coronavirus (aka the common cold), only zinc has repeatedly proven its efficacy in peer-reviewed studies. Zinc impedes viral replication, prophylaxing against colds and abbreviating their duration. The groaning shelves that commercial pharmacies devote to zinc-based cold remedies attest to its extraordinary efficacy. Yet Anthony Fauci never advised Americans to increase zinc uptake following exposure to infection.

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especially older adults.” As a coauthor of a 2017 paper by the International Society for Sports Nutrition, Dr. Lopez, along with contributors, stated that creatine not only enhances recovery, muscle mass, and strength in connection with exercise, but also protects against age-related muscle loss and various forms of brain injury.36 There’s even some evidence that creatine may boost our immune function and fat and carbohydrate metabolism. Generally well tolerated, creatine has a strong safety profile at a daily dose of three to five grams.37 7.

I Want The Golden World (The Sonnet) No matter what you say, I want the golden world. To hell with the sayers of nay, I keep working without reward. You may have your comfort, Enjoy all your luxuries futile. For me there's no other joy, Like making someone smile. All you do is take and take, Yet I have nothing against thee. Just remember that one day, You shall die of obesity. Vegetables can mock all they want. I shall die building the golden world.

The point of the BoPo movement isn’t necessarily for everyone to simply just “love” their bodies or feel positively about them, but rather, to take a stance against social norms and pressures of what society says beauty “should” be by bringing adequate representation to people of color, people of different ethnicities, people from LGBTQIA+ communities, older adults, and those with disabilities.44 But rather than bringing adequate representation and diversity to society’s ideal body standards, what has unfortunately happened is that many thin, fit, White, and conventionally attractive people, specifically cisgender White women, have taken its message to simply be “love yourself despite your ‘imperfections.’” They’ve taken something that wasn’t meant for them to be used to further validate their own beauty standards.

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In the 1980s, Lewis Landsberg, a Harvard endocrinologist who would later become dean of the Northwestern University School of Medicine, discovered yet another mechanism by which insulin works to increase blood pressure and perhaps induce hypertension—in this case, by stimulating the central nervous system. Landsberg’s revelation has since been integrated into established thinking as an explanation for why the obese are hypertensive: they’re insulin-resistant, with chronically elevated levels of insulin, which in turn stimulates the nervous system, increasing heart rate, constricting blood vessels, and chronically elevating blood pressure. Since the obese seem to have increased sympathetic nervous activity, it makes perfect sense.

women who are sixty-four pounds above average weight are paid 9 percent less than women in the normal range, equivalent to three years of work experience. Wage discrimination against the obese occurs across a variety of countries, ethnic groups, and professions. In laboratory studies, candidates with identical qualifications are less likely to be hired or promoted and are offered lower salaries if they are described as obese.

I was relieved to come across a more expansive population study of nearly seventy thousand patients that showed that the medical care given to overweight patients is no different than what non-overweight patients receive.14 Despite an ingrained societal bias against obesity—one that affects physicians as well as patients—the medical profession seems to be able to deliver comparable treatment.

Washington figures like Nancy Pelosi lined up against HCQ on the incredible grounds that it was “something that has not been approved by scientists,” and added that the drug wasn’t intended for the likes of the “morbidly obese” President Trump.

The diet and lifestyle changes for the Tokelauans who immigrated to New Zealand were abrupt and even more dramatic. Bread and potatoes replaced breadfruit in their diets; meat replaced fish; they hardly ate any coconuts. Sugar consumption skyrocketed, as did physical activity: the men went to work as manual laborers in the forest service or on the railway, and the women got jobs in electrical assembly plants or clothing factories, or they cleaned offices during the evening hours, walking miles to and from work. In both populations, a similar pattern of chronic diseases erupted with the Westernization of the diet. Between the late 1960s and early 1980s, diabetes prevalence shot upward, particularly among the immigrants. By 1982, almost 20 percent of the immigrant women and 11 percent of the immigrant men—one in five and one in nine, respectively—were diabetic. Hypertension, heart disease, and gout also increased significantly, particularly in the migrant population (the migrants were nine times as likely to get gout as those remaining behind on the atolls). Obesity, unsurprisingly, also increased: Both men and women gained, on average, between twenty and thirty pounds. Children, too, got fatter.

The medical research community came to recognize that insulin resistance and a condition now known as “metabolic syndrome” is a major, if not the major, risk factor for heart disease and diabetes. Before we get either heart disease or diabetes, we first manifest metabolic syndrome. The CDC now estimates that some seventy-five million adult Americans have metabolic syndrome. The very first symptom or diagnostic criterion that doctors are told to look for in diagnosing metabolic syndrome is an expanding waistline. This means that if you’re overweight or obese—as two-thirds of American adults are—there’s a good chance that you have metabolic syndrome; it also means that your blood pressure is likely to be elevated, and you’re glucose-intolerant and thus on the way to becoming diabetic. This is why you’re more likely to have a heart attack than a lean individual—although lean individuals can also have metabolic syndrome, and those who do are more likely to have heart disease and diabetes than lean individuals without it. Metabolic syndrome ties together a host of disorders that the medical community typically thought of as unrelated, or at least having separate and distinct causes—getting fatter (obesity), high blood pressure (hypertension), high triglycerides, low HDL cholesterol (dyslipidemia), heart disease (atherosclerosis), high blood sugar (diabetes), and inflammation (pick your disease)—as products of insulin resistance and high circulating insulin levels (hyperinsulinemia). It’s a kind of homeostatic disruption in which regulatory systems throughout the body are misbehaving with slow, chronic, pathological consequences everywhere.

But if sugar actually causes insulin resistance—as the biochemistry and the animal experiments suggest—then it also is the very likely trigger of excess fat accumulation and thus obesity. Remove the sugar, and the insulin resistance improves and weight is lost, not because the subjects ate less, which they may have, but because their insulin resistance resolved.

Women who are glucose-intolerant during their pregnancies will have children who are born larger and fatter than women who aren’t, and those children will carry a greater risk of obesity

All these women will have higher blood sugar on average than women who remain lean and healthy; their triglycerides will be higher as well. This would explain why maternal obesity, as has been documented repeatedly, is a strong risk factor for childhood obesity and among the strongest predictors of metabolic syndrome and obesity in adulthood. This implies, of course, that if insulin-resistant, obese, and/or diabetic mothers give birth to children who are more predisposed to being insulin-resistant, obese, and diabetic when they, in turn, are of childbearing age, the problem will get worse with each successive generation—a “vicious cycle,” as it’s often described in the medical literature by researchers who pay attention to the issue.

The ADA, for instance, calls it a “myth” that sugar causes type 2 diabetes, because that’s caused by “genetics and lifestyle factors” that make us fat—i.e., “calories from any source.” It then proceeds to recommend that we all avoid sugar-sweetened beverages to prevent diabetes, adding that we can “save money” by doing so. The organization accepts the role of fat accumulation in the liver as quite possibly a causal factor in the development of insulin resistance, diabetes, and obesity, but ignores the evidence building steadily since the 1980s that implicates sugars as the cause of that hepatic fat accumulation.

Artificial sweeteners (noncaloric sweeteners, as the USDA calls them) as a replacement for sugar muddy these waters even more. Much of the anxiety about these sweeteners was generated in the 1960s and 1970s by the research, partly funded by the sugar industry, as we’ve seen, that led to the banning of cyclamates as a possible carcinogen, and the suggestion that saccharin could cause cancer (at least in rats, at extraordinarily high doses). Though this particular anxiety has tapered off with time, it has been replaced by the suggestion that maybe these artificial sweeteners can cause metabolic syndrome, and thus obesity and diabetes. This conjecture comes primarily from epidemiological studies that show an association between the use of artificial sweeteners and obesity and diabetes. But whether this means artificial sweeteners cause obesity and diabetes is, again, impossible to say.

PROVISIONAL LIST OF WESTERN DISEASES Metabolic and cardiovascular: essential hypertension, obesity, diabetes mellitus (type II), cholesterol gallstones, cerebrovascular disease, peripheral vascular disease, coronary heart disease, varicose veins, deep vein thrombosis, and pulmonary embolism Colonic: constipation, appendicitis, diverticular disease, haemorrhoids; cancer and polyp of large bowel Other diseases: dental caries, renal stone, hyperuricaemia and gout, thyroidtoxicosis, pernicious anaemia, subacute combined degeneration, also other forms of cancer such as breast and lung HUGH TROWELL AND DENIS BURKITT, Western Diseases: Their Emergence and Prevention, 1981

When populations underwent Westernization, chronic diseases emerged with it, whether rapid or not, and typically in the same order, beginning with periodontal disease (tooth decay), gout, obesity, diabetes, and hypertension, and eventually encompassing all of them.

In 2003, epidemiologists from the Centers for Disease Control, led by Eugenia Calle, published an analysis in The New England Journal of Medicine reporting that cancer mortality in the United States was clearly associated with obesity and overweight. The heaviest men and women, they reported, were 50 and 60 percent more likely, respectively, to die from cancer than the lean. This increased risk of death held true for a host of common cancers—esophageal, colorectal, liver, gallbladder, pancreatic, and kidney cancers, as well as, in women, cancers of the breast, uterus, cervix, and ovary. In 2004, the CDC followed up with an analysis linking cancer to diabetes, particularly pancreatic, colorectal, liver, bladder, and breast cancers. Cancer researchers trying to make sense of this association would later say that something about cancer seems to thrive on the metabolic environment of the obese and the diabetic. One conspicuous clue as to what that something might be was that the same association was seen with people who weren’t obese and diabetic (or at least not yet) but suffered only from metabolic syndrome and thus were insulin-resistant. The higher their levels of circulating insulin, and that of a related hormone known as insulin-like growth factor, the greater the likelihood that they would get cancer.

There is no fat accumulation without insulin. Insulin shunts sugar to fat. It makes your fat cells grow. The more insulin, the more fat, period.

If fiber can protect against elevated insulin, then it should protect against type 2 diabetes, right? That’s exactly what the studies show.

The battle of the bulge is a battle against biology, so obesity is not some moral failing. I can’t stress enough that becoming overweight is a normal, natural response to the abnormal, unnatural ubiquity of calorie-dense, sugary, and fatty foods.