Vascular Quotes

You don't know when you're twenty-three. You don't know what it really means to crawl into someone else's life and stay there. You can't see all the ways you're going to get tangled, how you're going to bond skin to skin. How the idea of separating will feel in five years, in ten - in fifteen. When Georgie thought about divorce now, she imagined lying side by side with Neal on two operating tables while a team of doctors tried to unthread their vascular systems. She didn't know at twenty-three.

Cut these words and they would bleed; they are vascular and alive.

Chronic rage, by contrast, floods the system with stress hormones long past the allotted time. Over the long term, such a hormonal surplus, whatever may have instigated it, can make us anxious or depressed; suppress immunity; promote inflammation; narrow blood vessels, promoting vascular disease throughout the body;

In Spanish there is a word for which I can't find a counter word in English. It is the verb vascular, present participle vacilando. I does not mean vacillating at all. If one is vacilando, he is going somewhere but doesn't greatly care whether or not her gets there, although he has direction. . . We could choose some article almost certain not to exist there and then diligently try to find it.

I'll catch any rose in my vase-shaped heart, then process it through my vascular system, until there's nothing left.

The vascular-system poster did, however, include a small ‘female pelvis’ off to one side, and me and my female pelvis were grateful for small mercies.

This has been a novel about some people who were punished entirely too much for what they did. They wanted to have a good time, but they were like children playing in the street; they could see one after another of them being killed--run over, maimed, destroyed--but they continued to play anyhow. We really all were very happy for a while, sitting around not toiling but just bullshitting and playing, but it was for such a terrible brief time, and then the punishment was beyond belief: even when we could see it, we could not believe it. For example, while I was writing this I learned that the person on whom the character Jerry Fabin is based killed himself. My friend on whom I based the character Ernie Luckman died before I began the novel. For a while I myself was one of these children playing in the street; I was, like the rest of them, trying to play instead of being grown up, and I was punished. I am on the list below, which is a list of those to whom this novel is dedicated, and what became of each. Drug misuse is not a disease, it is a decision, like the decision to step out in front of a moving car. You would call that not a disease but an error in judgment. When a bunch of people begin to do it, it is a social error,a life-style. In this particular life-style the motto is "Be happy now because tomorrow you are dying," but the dying begins almost at once, and the happiness is a memory. It is, then, only a speeding up, an intensifying, of the ordinary human existence. It is not different from your life-style, it is only faster. It all takes place in days or weeks or months instead of years. "Take the cash and let the credit go," as Villon said in 1460. But that is a mistake if the cash is a penny and the credit a whole lifetime. There is no moral in this novel; it is not bourgeois; it does not say they were wrong to play when they should have toiled;it just tells what the consequences were. In Greek drama they were beginning, as a society, to discover science, which means causal law. Here in this novel there is Nemesis: not fate, because any one of us could have chosen to stop playing in the street, but, as I narrate from the deepest part of my life and heart, a dreadful Nemesis for those who kept on playing. I myself,I am not a character in this novel; I am the novel. So, though, was our entire nation at this time. This novel is about more people than I knew personally. Some we all read about in the newspapers. It was, this sitting around with our buddies and bullshitting while making tape recordings, the bad decision of the decade, the sixties, both in and out of the establishment. And nature cracked down on us. We were forced to stop by things dreadful. If there was any "sin," it was that these people wanted to keep on having a good time forever, and were punished for that, but, as I say, I feel that, if so, the punishment was far too great, and I prefer to think of it only in a Greek or morally neutral way, as mere science, as deterministic impartial cause-and-effect. I loved them all. Here is the list, to whom I dedicate my love: To Gaylene deceased To Ray deceased To Francy permanent psychosis To Kathy permanent brain damage To Jim deceased To Val massive permanent brain damage To Nancy permanent psychosis To Joanne permanent brain damage To Maren deceased To Nick deceased To Terry deceased To Dennis deceased To Phil permanent pancreatic damage To Sue permanent vascular damage To Jerri permanent psychosis and vascular damage . . . and so forth. In Memoriam. These were comrades whom I had; there are no better. They remain in my mind, and the enemy will never be forgiven. The "enemy" was their mistake in playing. Let them all play again, in some other way, and let them be happy.

The temperature in that hangar would sometimes get down to 40 degrees, and very often I had to put on long underwear, which was so restrictive I suffered from an acute vascular disorder for days afterward.

Your spirit shouldn’t be ‘fine.’ It should be effervescent.” The “spirit” in question wasn’t the soul. Nothing so abstract. It was spirit of the body—the clear fluid pumped by the second heart through its own network of vessels, subtler and more mysterious than the primary vascular system. Its function wasn’t properly understood by science. You could live even if your second heart stopped and the spirit hardened in your veins. But it did have some connection to vitality, or “passion,” as Master Hyrrokkin said, and those without it were emotionless, lethargic. Spiritless.

What does separation look like? A wall? A wave? A body of water? A ripple of light or a shimmer of subatomic particles, parting? What does it feel like to push through? Her fingers press against the rag surface of her dream, recognize the tenacity of filaments and know that it is paper about to tear, but for the fibrous memory that still lingers there, supple, vascular, and standing tall. The tree was past and the paper is present, and yet paper still remembers holding itself upright and altogether. Like a dream, it remembers its sap.

Du Bois Reymond spoke of “a general feeling of disorder” at the very start of his attacks, and other patients speak, simply, of feeling “unsettled.” In this unsettled state one may feel hot or cold, or both (see, for example, Case 9); bloated and tight, or loose and queasy; a peculiar tension, or languor, or both; there are head pains, or other pains, sundry strains and discomforts, which come and go. Everything comes and goes, nothing is settled, and if one could take a total thermogram, or scan, or inner photograph of the body, one would see vascular beds opening and closing, peristalsis accelerating or stopping, viscera squirming or tightening in spasms, secretions suddenly increasing or lessening—as if the nervous system itself was in a state of indecision.

You don’t know what it really means to crawl into someone else’s life and stay there. You can’t see all the ways you’re going to get tangled, how you’re going to bond skin to skin. How the idea of separating will feel in five years, in ten—in fifteen. When Georgie thought about divorce now, she imagined lying side by side with Neal on two operating tables while a team of doctors tried to unthread their vascular systems.

Cum atâția ani irosiți cu tatăl meu lăsaseră niște goluri destul de mari, viața mamei a fost ca o continuă învățare de a le umple, cum sunt victimele unui accident vascular cerebral care învață din nou cuvintele uzuale. Felul timid în care se privea în oglindă, la fel de critic și plin de speranță ca un adolescent. Modul în care-și prindea bretonelul scurt cu două clămițe, pentru că, așa cum spunea ea „îmi intră-n ochi la serviciu”...

The way the universe sat waiting to become, quietly, in the nether of space and time, you too remain some cellular snuggle dangling between my legs, curled in the warm swim of my mostly quietest self. If you come to be — And who knows? — I wonder, little bubble of unbudded capillaries, little one ever aswirl in my vascular galaxies, what would you think of this world which turns itself steadily into an oblivion that hurts, and hurts bad?

vascular patterning

(Ear cartilage is similarly underserved by the vascular system, so if you plan on picking a fight with Mike Tyson, do practice good wound toilet.)

One of the advantages of having a binary vascular system was that he could always pump his blood faster than normal if he chose to, raising his body temperature at will.

Words so vascular and alive they would bleed if you cut them, words that walked and ran.

When Georgie thought about divorce now, she imagined lying side by side with Neal on two operating tables while a team of doctors tried to unthread their vascular systems.

To help with cardiovascular issues, try the Zona Plus, a digitally controlled handheld device that uses the science behind isometric exercise to increase both vascular flexibility

omega-3 consumption “lowers plasma triglycerides, resting heart rate, and blood pressure and might also improve myocardial filling and efficiency, lower inflammation, and improve vascular function.

Cum atâția ani irosiți cu tatăl meu lăsaseră niște goluri destul de mari, viața ei a fost ca o continuă învățare de a le umple, cum sunt victimele unui accident vascular cerebral care învață din nou cuvintele uzuale. Felul timid în care se privea în oglindă, la fel de critic și plin de speranță ca un adolescent. Modul în care-și prindea bretonelul scurt cu două clămițe, pentru că, așa cum spunea ea „îmi intră-n ochi la serviciu”...

This omnipresent cult of the body is extraordinary. It is the only object on which everyone is made to concentrate, not as a source of pleasure, but as an object of frantic concern, in the obsessive fear of failure or substandard performance, a sign and an anticipation of death, that death to which no one can any longer give a meaning, but which everyone knows has at all times to be prevented. The body is cherished in the perverse certainty of its uselessness, in the total certainty of its non-resurrection. Now, pleasure is an effect of the resurrection of the body, by which it exceeds that hormonal, vascular and dietetic equilibrium in which we seek to imprison it, that exorcism by fitness and hygiene. So the body has to be made to forget pleasure as present grace, to forget its possible metamorphosis into other forms of appearance and become dedicated to the utopian preservation of a youth that is, in any case, already lost. For the body which doubts its own existence is already half-dead, and the current semi-yogic, semi-ecstatic cult of the body is a morbid preoccupation. The care taken of the body while it is alive prefigures the way it will be made up in the funeral home.

WHAT’S GOOD FOR THE HEART IS GOOD FOR THE BRAIN. That is, vascular health (meaning low apoB, low inflammation, and low oxidative stress) is crucial to brain health. WHAT’S GOOD FOR THE LIVER (AND PANCREAS) IS GOOD FOR THE BRAIN. Metabolic health is crucial to brain health. TIME IS KEY. We need to think about prevention early, and the more the deck is stacked against you genetically, the harder you need to work and the sooner you need to start. As with cardiovascular disease, we need to play a very long game. OUR MOST POWERFUL TOOL FOR PREVENTING COGNITIVE DECLINE IS EXERCISE. We’ve talked a lot about diet and metabolism, but exercise appears to act in multiple ways (vascular, metabolic) to preserve brain health; we’ll get into more detail in Part III, but exercise—lots of it—is a foundation of our Alzheimer’s-prevention program.

The point I want to make about methanogens is that they were the losers in the race through a bottleneck, yet nonetheless survived in niche environments. Similarly, on a larger scale, it is rare for the loser to disappear completely, or for the latecomers never to gain at least a precarious foothold. The fact that flight had already evolved among birds did not preclude its later evolution in bats, which became the most numerous mammalian species. The evolution of plants did not lead to the disappearance of algae, or indeed the evolution of vascular plants to the disappearance of mosses.

When Franklin D. Roosevelt signed the Social Security Act in 1935, old age was defined as sixty-five years, yet estimated life expectancy in the United States at the time was sixty-one years for males and sixty-four years for females.62 A senior citizen today, however, can expect to live eighteen to twenty years longer. The downside is that he or she also should expect to die more slowly. The two most common causes of death in 1935 America were respiratory diseases (pneumonia and influenza) and infectious diarrhea, both of which kill rapidly. In contrast, the two most common causes of death in 2007 America were heart disease and cancer (each accounted for about 25 percent of total deaths). Some heart attack victims die within minutes or hours, but most elderly people with heart disease survive for years while coping with complications such as high blood pressure, congestive heart failure, general weakness, and peripheral vascular disease. Many cancer patients also remain alive for several years following their diagnosis because of chemo-therapy, radiation, surgery, and other treatments. In addition, many of the other leading causes of death today are chronic illnesses such as asthma, Alzheimer’s, type 2 diabetes, and kidney disease, and there has been an upsurge in the occurrence of nonfatal but chronic illnesses such as osteoarthritis, gout, dementia, and hearing loss.63 Altogether, the growing prevalence of chronic illness among middle-aged and elderly individuals is contributing to a health-care crisis because the children born during the post–World War II baby boom are now entering old age, and an unprecedented percentage of them are suffering from lingering, disabling, and costly diseases. The term epidemiologists coined for this phenomenon is the “extension of morbidity.

that drinking diet soda was associated with a 43 percent increase in risk of vascular events (strokes and heart attacks). The 2008 Atherosclerosis Risk in Communities Study (ARIC)10 found a 34 percent increased incidence of metabolic syndrome in diet soda users, which is consistent with data from the 2007 Framingham Heart Study,11 which showed a 50 percent higher incidence of metabolic syndrome. In 2014, Dr. Ankur Vyas from the University of Iowa Hospitals and Clinics 12 presented a study following 59,614 women over 8.7 years in the Women’s Health Initiative Observational Study. The study found a 30 percent increase risk of cardiovascular events (heart attacks and

Before I can think to doubt her for whatever reason she hurries to charge my lowly spirit with her succulent lips. Reaching for her waist my hands feel for her flesh beyond her grey ribbed sweater. More to me than the beauty of the earth it is even her name that causes me to tremble when I am close to her. The propinquity of her lissome figure arched against my body is now soup to my broken heart. Her kiss and her touch allowing love and blood to again souse the channels hastening through my vascular body. My arms hold on to her like I can never let her go. Warming her nose against my face she again offers me those lips in that sure way of which I am familiar. Knowing now just as I always have that there can be no love worthy or memorable enough to ever take her place.

This tragic sequence helps explain the fearful loss of cognition in coronary artery bypass patients.3 But neuroradiologists also report that using magnetic resonance imaging, they can detect little white spots in the brains of Americans starting at about age fifty. These spots represent small, asymptomatic strokes (see Figures 18 and 19 in insert). The brain has so much reserve capacity that at first these tiny strokes cause no trouble. But, if they continue, they begin to cause memory loss and, ultimately, crippling dementia. In fact, one recently reported study found that the presence of these “silent brain infarcts” more than doubles the risk of dementia.4 We now believe, in fact, that at least half of all senile mental impairment is caused by vascular injury to the brain.

The physical heart, which houses the spiritual heart, beats about 100,000 times a day, pumping two gallons of blood per minute and over 100 gallons per hour. If one were to attempt to carry 100 gallons of water (whose density is lighter than blood) from one place to another, it would be an exhausting task. Yet the human heart does this every hour of every day for an entire lifetime without respite. The vascular system transporting life-giving blood is over 60,000 miles long—more than two times the circumference of the earth. So when we conceive of our blood being pumped throughout our bodies, know that this means that it travels through 60,000 miles of a closed vascular system that connects all the parts of the body—all the vital organs and living tissues—to this incredible heart.

Watching It Happen I laze about, deranged and unafraid to godly kiss you, kiss the pharmacist that whipped you, undilute, to dilate high your animus of lime and lye. I know of an upstairs hell. A creamy, vascular thump through bonus years of things that pass and things that do not move. Your cellular mouth. Your mess of inattention. Now that none of us are good looking I think that/they are right. Strokes of light you taped across my nipple. Patterns staked to fake the love we cannot feel so slick the miser of your hand through my bad heart. Genius, you are blond enough. Once in a while. And in the end, when I sweep coolly up and will not be drawn back, then I will tell you of it. How I can. In writing, I am making an attempt to depict my beautiful nose through imagery. I will tell you of it. Once in a while. I will miss you. And the tape. To be flung down, petals from a balcony.

He ran long at the White House, and arrived late to his next meeting with Hillary Clinton, Jake Sullivan and Frank Ruggiero—their first major strategy session on Taliban talks after the secret meeting with A-Rod. She was waiting in her outer office, a spacious room paneled in white and gilt wood, with tasseled blue and pink curtains and an array of colorfully upholstered chairs and couches. In my time reporting to her later, I only ever saw Clinton take the couch, with guests of honor in the large chair kitty-corner to her. She’d left it open for him that day. “He came rushing in. . . . ” Clinton later said. “And, you know, he was saying ‘oh I’m so sorry, I’m so sorry.’ ” He sat down heavily and shrugged off his coat, rattling off a litany of his latest meetings, including his stop-in at the White House. “That was typical Richard. It was, like, ‘I’m doing a million things and I’m trying to keep all the balls in the air,’ ” she remembered. As he was talking, a “scarlet red” flush went up his face, according to Clinton. He pressed his hands over his eyes, his chest heaving. “Richard, what’s the matter?” Clinton asked. “Something horrible is happening,” he said. A few minutes later, Holbrooke was in an ambulance, strapped to a gurney, headed to nearby George Washington University Hospital, where Clinton had told her own internist to prepare the emergency room. In his typically brash style, he’d demanded that the ambulance take him to the more distant Sibley Memorial Hospital. Clinton overruled him. One of our deputies on the SRAP team, Dan Feldman, rode with him and held his hand. Feldman didn’t have his BlackBerry, so he scrawled notes on a State Department expense form for a dinner at Meiwah Restaurant as Holbrooke dictated messages and a doctor assessed him. The notes are a nonlinear stream of Holbrooke’s indomitable personality, slashed through with medical realities. “Call Eric in Axelrod’s office,” the first read. Nearby: “aortic dissection—type A . . . operation risk @ > 50 percent”—that would be chance of death. A series of messages for people in his life, again interrupted by his deteriorating condition: “S”—Secretary Clinton—“why always together for medical crises?” (The year before, he’d been with Clinton when she fell to the concrete floor of the State Department garage, fracturing her elbow.) “Kids—how much love them + stepkids” . . . “best staff ever” . . . “don’t let him die here” . . . “vascular surgery” . . . “no flow, no feeling legs” . . . “clot” . . . and then, again: “don’t let him die here want to die at home w/ his fam.” The seriousness of the situation fully dawning on him, Holbrooke turned to job succession: “Tell Frank”—Ruggiero—“he’s acting.” And finally: “I love so many people . . . I have a lot left to do . . . my career in public service is over.” Holbrooke cracked wise until they put him under for surgery. “Get me anything you need,” he demanded. “A pig’s heart. Dan’s heart.

S.P. is a 68-year-old retired painter who is experiencing right leg calf pain. The pain began approximately 2 years ago but has become significantly worse in the past 4 months. The pain is precipitated by exercise and is relieved with rest. Two years ago, S.P. could walk two city blocks before having to stop because of leg pain. Today, he can barely walk across the yard. S.P. has smoked two to three packs of cigarettes per day (PPD) for the past 45 years. He has a history of coronary artery disease (CAD), hypertension (HTN), peripheral vascular disease (PVD), and osteoarthritis. Surgical history includes quadruple coronary artery bypass graft (CABG × 4) 3 years ago. He has had no further symptoms of cardiopulmonary disease since that time, even though he has not been compliant with the exercise regimen his cardiologist prescribed, he continues to eat anything he wants, and continues to smoke two to three PPD. Other surgical history includes open reduction internal fixation of the right femoral fracture 20 years ago. S.P. is in the clinic today for a routine semiannual follow-up appointment with his primary care provider. As you take his vital signs, he tells you that, besides the calf pain, he is experiencing right hip pain that gets worse with exercise, the pain doesn't go away promptly with rest, some days are worse than others, and his condition is not affected by a resting position. � Chart View General Assessment Weight 261 lb Height 5 ft, 10 in. Blood pressure 163/91 mm Hg Pulse 82 beats/min Respiratory rate 16 breaths/min Temperature 98.4° F (36.9° C) Laboratory Testing (Fasting) Cholesterol 239 mg/dL Triglycerides 150 mg/dL HDL 28 mg/dL LDL 181 mg/dL Current Medications Lisinopril (Zestril) 20 mg/day Metoprolol (Lopressor) 25 mg twice a day Aspirin 325 mg/day Simvastatin (Zocor) 20 mg/day Case Study 4 Name Class/Group Date ____________________ Group Members INSTRUCTIONS All questions apply to this case study. Your responses should be brief and to the point. When asked to provide several

attack, and stroke among 17,800 patients randomly assigned to receive either Rosuvastatin or placebo for over four years. Source: P. M. Ridker, “Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein,” New England Journal of Medicine 359 (2008): 2195–207.

There is not a scientist on earth today who can fully explain and replicate the flight efficiency of a single insect or the swimming ability of any fish. No man-made pump and piping can match the efficiency of the human heart and vascular system. Globally, we devote huge amounts of energy to cool our computers, yet nature's super-computer, the human brain, has not heating problem at all. As we'll see repeatedly throughout this book, nature always uses the least energy and the least materials for the job. Nature and humans use dramatically opposed strategies for drag reduction and neither borrows from the other.

The consensus reached at a recent NICHD/NIH sponsored workshop is that preeclampsia is a multifactorial disease whose pathogenesis is not solely vascular, genetic, immunologic, or environmental but a complex combination of factors (Ilekis et al. , 2007

brain and other nerve-related problems such as headaches from concussions, vascular dementia (dementia caused by blood vessel problems in the brain), migraines, Bell’s palsy (a paralysis of the facial nerve), and tinnitus (ringing of the ears). He emphasized he was influenced by research that had been done in Israel on light therapy and the brain. Dr. Shimon Rochkind, a neurosurgeon at Tel Aviv University, originally pioneered work using lasers to treat injuries in the peripheral nervous system, that is, all the nerves in the body except those in the brain and spinal cord. Injury to peripheral nerves can lead to problems sensing or moving.

The common embryological origin of the endothelium and blood cells perhaps explains why many cytokines that control hematopoiesis are released by the vascular endothelium.

Bisphosphonates comprise a unique class of medications that has been shown to inhibit osteoclasts and possibly interfere with angiogenesis through actions such as inhibition of vascular endothelial growth factor

detonar las cefaleas. Es imposible enumerar todos los posibles culpables, pero puedo ofrecerte algunos consejos para ponerle fin al sufrimiento: Establece horarios estrictos para dormir. Es la clave para regular las hormonas del cuerpo y mantener la homeostasis, es decir, el estado predilecto del cuerpo en el que su fisiología está equilibrada. Deshazte de la grasa. Mientras más peses, es más probable que padezcas cefaleas. Mantente activo. El sedentarismo fomenta la inflamación. Modera tu consumo de cafeína y alcohol. Beberlos en exceso puede detonar dolores de cabeza. No te saltes comidas y no tengas hábitos alimenticios erráticos. Al igual que con el sueño, tener patrones de alimentación ordenados controla varios procesos hormonales que pueden influir en el riesgo de padecer cefaleas. Maneja el estrés emocional, la ansiedad, la preocupación y todo tipo de emociones fuertes. Éstas están entre los detonantes más comunes de los dolores de cabeza. Quienes sufren migrañas suelen ser sensibles a los eventos estresantes, los cuales dan pie a la liberación de ciertas sustancias químicas en el cerebro que pueden provocar cambios vasculares y causar una migraña. Para colmo de males, las emociones como la ansiedad y la preocupación incrementan la tensión muscular y dilatan los vasos sanguíneos, lo cual intensifica la gravedad de la migraña. Adopta una dieta sin gluten, sin aditivos y sin alimentos procesados. La dieta de bajo índice glicémico, baja en carbohidratos y alta en grasas saludables que delineo en el capítulo 11 te ayudará a reducir tu propensión a las cefaleas. Ten mucho cuidado con los quesos añejos, los embutidos y otras fuentes de glutamato monosódico (GMS, el cual suele encontrarse en la comida china), pues estos ingredientes pueden llegar a ser responsables hasta de 30% de las migrañas. Rastrea los patrones de tus experiencias con la cefalea. Eso te permitirá saber cuándo estás más vulnerable a ellas, de manera que puedas prestar más atención en esos momentos. Las mujeres, por ejemplo, con frecuencia pueden rastrear patrones relacionados con su ciclo menstrual. Si eres capaz de definirlos, entenderás mejor tus propios dolores de cabeza y actuarás en función de ellos.

Chlorophyll: builds a high red blood cell count helps prevent cancer provides iron to organs makes the body more alkaline counteracts toxins eaten improves anemic conditions cleans and deodorizes bowel tissues helps purify the liver aids hepatitis improvement regulates menstruation aids hemophilia condition improves milk production helps sores heal faster eliminates body odors resists bacteria in wounds cleans tooth and gum structure in pyorrhea eliminates bad breath relieves sore throat makes an excellent oral surgery gargle benefits inflamed tonsils soothes ulcer tissues soothes painful hemorrhoids and piles aids catarrhal discharges revitalizes vascular system in the legs improves varicose veins reduces pain caused by inflammation improves vision

The generally reported lack of relationship between the severity of diabetes and the vascular complications… suggest that hyperglycemia is not the factor linking diabetes with atherosclerosis. The possibility that insulin contributes to the development of the large vessel complications of diabetes has been explored, and evidence has been presented that insulin stimulates arterial smooth muscle cell proliferation and lipid synthesis in the arterial wall.   —”Diabetes and atherosclerosis.” In J. S. Bajaj, ed. Insulin and Metabolism. Amsterdam, London, New York: Excerpta Medica 27(1979): 1-13.

Those with cardiovascular disease not identified with diabetes are simply undiagnosed. Dr. Stout in 1977 identified the origin of the pathology of type 2 diabetes as vascular (arterial), directly related to hyperinsulinemia and not to hypergly-cemia.

The clogging of the arteries inside, and leading to, the brain with cholesterol-filled plaque can drastically reduce the amount of blood—and therefore oxygen—your brain receives. Supporting this theory, autopsies have demonstrated that Alzheimer’s patients had particularly significant arterial blockage in the arteries leading to the memory centers of their brains.75 In light of such findings, some experts have even suggested that Alzheimer’s be reclassified as a vascular disorder.76

Soy consumption has been clearly linked to a higher risk of vascular dementia, or Alzheimer’s disease, in men (White et al. 1996). The isoflavones of soy inhibit the enzyme conversion of testosterone to estradiol via the aromatase enzyme, which is necessary for male brain function and maintenance (Irvine et al. 1998).

I walked under the arch—Empire State Building in front, Freedom Tower behind—glorious to be here, on this day, some new beat in my vascular system, an anticipatory cadence that matched the wider pulse of traffic and construction noise. Life, life. Manhattan was saying it. In the interstices between tragedies, the spaces between the arrowing buildings, the rush of air in alleyways and tunnels, breezes across rooftops, life. So much sweat and energy absorbed by the inanimate, I thought, if you removed every human from this island the stones would cry out. Faulkner said the East and Middlewest—New York, Chicago—are young because they’re alive, the South old because it’s dead. Killed by the Civil War. Maybe that was what I felt. I’d come up from Nashville to find myself among the living.

We do know that blood pressure is controlled by the tiny smooth muscles lining the interior of blood vessels and the nerves that control them. These muscles’ ability to dilate or constrict governs the pressure and blood flow to each organ and tissue, thus allowing the body to adapt to various states such as sleep, digestion, or exercise, as well as to external circumstances such as a hot or cold environment. When the muscles throughout the vascular system dilate, blood pressure drops. When the muscles constrict, blood pressure rises. If this constriction occurs continuously, the blood pressure remains abnormally high. This is hypertension. What influences the relaxing and tightening of the tiny smooth muscles lining the blood vessels? Many factors, but among the foremost is the mineral magnesium. Actually, the balance of magnesium and another mineral, calcium, in and around the muscle cells lining the arteries is a primary determinant of their state of relaxation and constriction. Calcium tends to make muscles constrict, whereas magnesium causes them to relax.

This migration to higher transport property is induced by vascular endothelial growth factor (VEGF), analogous to the pathophysiology of diabetic retinopathy.

The word “moss” is commonly applied to plants which are not actually mosses. Reindeer “moss” is a lichen, Spanish “moss” is a flowering plant, sea “moss” is an alga, and club “moss” is a lycophyte. So what is a moss? A true moss or bryophyte is the most primitive of land plants. Mosses are often described by what they lack, in comparison to the more familiar higher plants. They lack flowers, fruits, and seeds and have no roots. They have no vascular system, no xylem and phloem to conduct water internally. They are the most simple of plants, and in their simplicity, elegant. With just a few rudimentary components of stem and leaf, evolution has produced some 22,000 species of moss worldwide. Each one is a variation on a theme, a unique creation designed for success in tiny niches in virtually every ecosystem.

Your extensive white matter damage causes faster cognitive decline and puts you at risk for dementia, stroke, and even death.10 White matter hyperintensities are part of the main pathology for vascular dementia, the second leading cause of dementia.

those self-grafted knots, the two trees join their vascular systems together and become one. Networked together underground by countless thousands of miles of living fungal threads, her trees feed and heal each other, keep their young and sick alive, pool their resources and metabolites into community chests. . . . It will take years for the picture to emerge. There

查尔姆斯工业大学毕业文凭【微信Q86013792】在线办理国外毕业证成绩单Chalmers University of Technology瑞典【真实留信认证】wse认证【国外原版证书文凭】offer入取通知书办理Now, moving into my current situation, I have my soon to be 87 year old mother with vascular dementia living with us. She has, over the past 6 years, been having seizures that have brought on different aspects of her dementia. She had about 3 years since her last major seizure but,

if I want to know a poem, Biblically, respiratorily, cardio- vascularly, I chart the rhythms of its lines—and I no longer fear that beat interests me so deeply because I was a child beaten to the 4/4 beat

Now, I’ve been using the term choked a little loosely,” I said to the jurors. “You’ll hear testimony from a physician that what the defendant used was a ‘vascular hold,’ a grip to cut off the flow of blood from arteries to the brain. Police departments used to do this to restrain unruly suspects… until the suspects started dying.

One of the common myths about eating is that it is easy and instinctive. Eating is actually the most complex physical task humans engage in. It is the only physical task that utilizes all of the body’s organ systems: the brain and cranial nerves; the heart and vascular system; the respiratory, endocrine, and metabolic systems; all the muscles of the body; and the entire GI tract. Swallowing alone requires the coordination of 26 muscles and six cranial nerves.

An orderly approach to cardio vascular disease, according to Beach, was to first relieve the inequality in the circulation, so that the burden is removed from the heart. After this has been accomplished, it is possible to see the real condition of the heart, and to treat it with heart-specific remedies, if necessary.

Once industrialisation ocurred, non-communicable (chronic) diseases (NCDs; e.g., cancers, cardiovascular disease, diabetes, cardio-vascular, and non-infectious respiratory diseases) started to rise and replace infections. Tobacco use, physical inactivity, unhealthy diets and the harmful use of alcohol are key risk factors for NCDs.

It is best to take L-arginine just before retiring for the night. Our vascular endothelial

Is Alzheimer’s a Vascular Disorder? In 1901, a woman named Auguste was taken to an insane asylum in Frankfurt, Germany, by her husband. She was described as a delusional, forgetful, disoriented woman who “could not carry out her homemaking duties.”66 She was seen by a Dr. Alzheimer and was to become the subject of the case that made Alzheimer a household name. On autopsy, Alzheimer described the plaques and tangles in her brain that would go on to characterize the disease. But lost in the excitement of discovering a new disease, a clue may have been overlooked. He wrote, “Die größeren Hirngefäße sind arteriosklerotisch verändert,” which translates to “The larger cerebral vessels show arteriosclerotic change.” He was describing the hardening of arteries inside his patient’s brain.67 We generally think of atherosclerosis as a condition of the heart, but it’s been described as “an omnipresent pathology that involves virtually the entire human organism.”68 You have blood vessels in every one of your organs, including your brain. The concept of “cardiogenic dementia,” first proposed in the 1970s, suggested that because the aging brain is highly sensitive to a lack of oxygen, lack of adequate blood flow may lead to cognitive decline.69 Today, we have a substantial body of evidence strongly associating atherosclerotic arteries with Alzheimer’s disease.70 Autopsies have shown repeatedly that Alzheimer’s patients tend to have significantly more atherosclerotic plaque buildup and narrowing of the arteries within the brain.71,72,73 Normal resting cerebral blood flow—the amount of blood circulating to the brain—is typically about a quart per minute. Starting in adulthood, people appear to naturally lose about half a percent of blood flow per year. By age sixty-five, this circulating capacity could be down by as much as 20 percent.74 While such a drop alone may not be sufficient to impair brain function, it can put you close to the edge. The clogging of the arteries inside, and leading to, the brain with cholesterol-filled plaque can drastically reduce the amount of blood—and therefore oxygen—your brain receives. Supporting this theory, autopsies have demonstrated that Alzheimer’s patients had particularly significant arterial blockage in the arteries leading to the memory centers of their brains.75 In light of such findings, some experts have even suggested that Alzheimer’s be reclassified as a vascular disorder.76

Chronic rage, by contrast, floods the system with stress hormones long past the allotted time. Over the long term, such a hormonal surplus, whatever may have instigated it, can – make us anxious or depressed; – suppress immunity; – promote inflammation; – narrow blood vessels, promoting vascular disease throughout the body; – encourage cancer growth; – thin the bones; – make us resistant to our own insulin, inducing diabetes; – contribute to abdominal obesity, elevating the risk of cardiovascular and metabolic problems; – impair essential cognitive and emotional circuits in the brain; and – elevate blood pressure and increase blood clotting, raising the risk of heart attacks or strokes.

L-arginine dysfunction is being seen in COVID patients and is associated with immune and vascular dysfunction.

FÓRMULA MEGAVITAMÍNICA Cada dos cápsulas contiene: Tocoferol (Vit. E) 600 IU PABA 50 mg Palmitato (Vit. A) 2.000 IU Hesperidina 200 mg Colecalciferol (Vit. D3) 5.000 IU Biotina 500 µg Inositol 200 mg Tiamina (B.1) 200 mg Riboflavina (B.2) 200 mg BHT 350 mg Niacina (B.3) 300 mg Colina 250 mg Ácido pantoténico (B.5) 300 mg  Zinc 25 mg Piridoxina (B.6) 50 mg Cianocobalamina (B.12) 5000 µg Folato 5000 mcg (en caso de polimorfismo MTRF, pedir 5THF) Betacaroteno 10.000 IU Selenio 75 µg Menaquinonas, menatetrenonas (K1, K2) 5000 µg Ascorbato o ascórbico 500 mg * Debido al volumen, deben usarse cápsulas 000, pudiendo variar su tamaño de no haber disponibilidad. Se regula el volumen de la mezcla aumentando o disminuyendo la cantidad de vitamina C (ya sea en forma de ácido ascórbico o de ascorbato de sodio, pero sin agregar otros excipientes. **  Del resto de los suplementos (por ejemplo, CoQ-10, L-Cisteína con B.1, o L-Carnitina con Ácido Lipoico), durante la fase de refeeding, pueden tomarse cantidades variables según se requieran y toleren. *** La vitamina C, en cualquiera de sus formas, debe tomarse a diario en todas las circunstancias. No hay ninguna razón para excluir este formidable nutriente esencial durante las fases de inanición ya que no portan valor energético (calorías) ni interrumpen la autofagia regenerativa. VITAMINA C (ácido ascórbico): Quizá el más poderoso y versátil antioxidante hidrosoluble, protege el cerebro y la médula espinal del constante ataque de los radicales libres. En los tejidos, garantiza una apropiada hidroxilacion del colágeno, protegiendo el endotelio vascular, cicatrizando heridas, fracturas, quemaduras y previniendo estrías. Disminuye el colesterol -al precipitar su conversión en ácidos biliares- así como el ácido úrico (C5H4N4O3). También es necesaria para fabricar neurotransmisores y hormonas. Es ergogénica, antitóxica, inmunoestimulante, anticancerígena, y antimutagénica. Su efecto quimioterapéutico mejora la eficacia de las drogas oncológicas a la vez que protege

In old age the blood can become cold, low, slow, and thick. This results in varicose veins, prolapse of tissues, less blood to the head, dizziness, mental vacuity, decline of mental and physical energy, arthritis, diabetes, stroke, vascular disease, or heart attack.

OUR MOST POWERFUL TOOL FOR PREVENTING COGNITIVE DECLINE IS EXERCISE. We’ve talked a lot about diet and metabolism, but exercise appears to act in multiple ways (vascular, metabolic) to preserve brain health; we’ll get into more detail in Part III, but exercise—lots of it—is a foundation of our Alzheimer’s-prevention program.

Scientists have been exploring the medical mysteries of the human heart for almost as long as poets have been probing its metaphorical depths. It is a wondrous organ, a tireless muscle that pumps blood around the body every moment of our lives. It pounds hard when we are exercising, slows down when we sleep, and even microadjusts its rate between beats, a hugely important phenomenon called heart rate variability. And when it stops, we stop. Our vascular network is equally miraculous, a web of veins, arteries, and capillaries that, if stretched out and laid end to end, would wrap around the earth more than twice (about sixty thousand miles, if you’re keeping score). Each individual blood vessel is a marvel of material science and engineering, capable of expanding and contracting dozens of times per minute, allowing vital substances to pass through its membranes, and accommodating huge swings in fluid pressure, with minimal fatigue. No material created by man can even come close to matching this.

Mosses are often described by what they lack, in comparison to the more familiar higher plants. They lack flowers, fruits, and seeds and have no roots. They have no vascular system, no xylem and phloem to conduct water internally. They are the most simple of plants, and in their simplicity, elegant. With just a few rudimentary components of stem and leaf, evolution has produced some 22,000 species of moss worldwide.

We will become able to act naturally within heat and cold and withstand all the elements of nature without significantly impacting our core body temperature. And it’s amazing what kinds of health benefits stem from there. Not only is it good for our vascular system, which again is the transportation system for all of the vitamins, oxygen, and nutrients our cells need, it also relieves the cells of biological stress. With that comes peace. Deep peace.

Our vascular system needs to be stimulated to achieve the desired muscular tone. It doesn’t need training, only awakening. Then, once it’s awakened and optimized, let’s say in ten days, a whole sequence of magic begins to occur within the body.

Cold showers are the gateway to flow and energy and peace. I’m not exaggerating. It’s the entry point from which you will learn the power of the mind over the body. If you do just ten days of cold showers after warm showers, meaning that you end your regular, warm showers with a minute or so of cold water, then you will be able to command your vascular system to close up when you go into the cold.

Hippies masquerading as pseudo philosophers love to tell anyone who will listen that reality doesn’t exist, it’s a construct, like everything else. But if reality doesn’t exist, then explain my shadow, the kid’s, the looks we receive. I remember coming home to you after receiving my extra shadow, both of us sore with shame and guilt. You were able to shed those feelings within a few days once the freshness wore off. But me, I’m simple—things designed to manipulate me tend to succeed. And my shadow is no exception. It follows me everywhere, a constant reminder of the one thing I can’t find it in me to talk about. I showed up to school and, seeing the shame in my eyes, one of my troubled kids pulled me aside and said, Old news, right, Miss? and I started crying on the spot. But you never blamed me, did you, Beau? It actually made me feel worse, as if I had to double the blame to make up for your understanding. If I was the only one blaming me, the guilt had no outlet, nothing to do but grow its own vascular system and circulate through my body. “What’s today going to be like?” I ask the kid. “Like yesterday, except today?” She is covered in snot, needing me.

The things she catches Doug-firs doing, over the course of these years, fill her with joy. When the lateral roots of two Douglas-firs run into each other underground, they fuse. Through those self-grafted knots, the two trees join their vascular systems together and become one. Networked together underground by countless thousands of miles of living fungal threads, her trees

Pomegranates inhibit breast cancer, prostate cancer, colon cancer, and leukemia, and prevent vascular changes that promote tumor growth in lab animals.55 2. Pomegranates inhibit angiotensin-converting enzymes and naturally lower blood pressure. (Angiotensin, as you may recall, is a hormone that promotes angiogenesis.)56 3. The potent antioxidative compounds in pomegranates reverse atherosclerosis and reduce excessive blood clotting and platelet clumping, factors that can lead to heart attacks and strokes.57 4. Pomegranates have estrogen-like compounds that stimulate serotonin and estrogen receptors, improving symptoms of depression and helping build bone mass in lab animals.58 5. Pomegranates reduce tissue damage in those with kidney problems, reduce the incidence of infections, and prevent serious infections.59 6. Lastly but impressively, pomegranates improve heart health. Heart patients with severe carotid artery blockages were given a daily dose of less than an ounce of pomegranate juice for a year. Not only did their blood pressure decrease by over 20 percent, but there was a 30 percent reduction in atherosclerotic plaque.60

Writing a long series of essays represents grafting the shoots from all the discordant elements of a person’s personality together into a unique, progressively created organism. Joining the vascular tissue of the conscious mind with the vaporous mist of the personal unconscious represents an act of asexual reproduction of a revised self through artistic inosculation.

Like high blood pressure and diabetes, chronic inflammation has no visible symptoms (though it can be measured by a lab test known as high-sensitivity C-reactive protein [hs CRP]). But it damages the vascular system, the organs, the brain, and body tissues. It slowly erodes your health, gradually overwhelming the body’s anti-inflammatory defenses. It causes heart disease. It causes cognitive decline and memory loss. Even obesity and diabetes are linked to inflammation because fat cells are veritable factories for inflammatory chemicals. In fact, it’s likely that inflammation is the key link between obesity and all the diseases obesity puts you at risk for developing. When your joints are chronically inflamed, degenerative diseases like arthritis are right around the corner. Inflamed lungs cause asthma and other respiratory illnesses. Inflammation in the brain is linked to Alzheimer’s disease and other neurological conditions, including brain fog and everyday memory lapses that we write off as normal aging—except those memory lapses are not an inevitable consequence of aging at all. They are, however, an inevitable consequence of inflammation, because inflammation sets your brain on fire. Those “I forgot where I parked the car” moments start happening more frequently, and occurring prematurely. Inflamed arteries can signal the onset of heart disease. Chronic inflammation has also been linked to various forms of cancer; it triggers harmful changes on a molecular level that result in the growth of cancer cells. Inflammation is so central to the process of aging and breakdown at the cellular level that some health pundits have begun referring to the phenomena as “inflam-aging.” That’s because inflammation accelerates aging, including the visible signs of aging we all see in the skin. In addition to making us sick, chronic inflammation can make permanent weight loss fiendishly difficult. The fat cells keep churning out inflammatory proteins called cytokines, promoting even more inflammation. That inflammation in turn prevents the energy-making structures in the cells, called mitochondria, from doing their jobs efficiently, much like a heat wave would affect the output of a factory that lacks air-conditioning—productivity declines under extreme conditions. One of the duties of the mitochondria is burning fat; inflammation interferes with the job of the mitochondria, making fat burning more difficult and fat loss nearly impossible. While someone trying to lose weight may initially be successful, after a while, the number on the scale gets stuck. The much-discussed weight-loss “plateau” is often a result of this cycle of inflammation and fat storage. And here’s even more bad news: Adding more exercise or eating fewer calories in an attempt to break through the plateau will have some effect on weight loss, but not much. And continuing to lose weight becomes much harder to accomplish. Why? Because inflammation decreases our normal ability to burn calories. (We’ll tell you more about other factors that contribute to the plateau—and how the Smart Fat Solution can help you to move beyond them—in Part 2 of this book.)

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These changes in stroke volume are due to alterations in circulating blood volume and systemic vascular resistance. Circulating

There is now good dietary information for the two chief conditions referring to mental decline. On the modest side, there is a condition called "cognitive impairment" or "cognitive dysfunction." This condition describes the declining ability to remember and think as well as one once did. It represents a continuum of disease ranging from cases that only hint at declining abilities to those that are much more obvious and easily diagnosed. Then there are mental dysfunctions that become serious, even life threatening. These are called dementia, of which there are two main types: vascular dementia and Alzheimer's disease. Vascular dementia is primarily caused by multiple little strokes resulting from broken blood vessels in the brain. It is common for elderly people to have "silent" strokes in their later years. A stroke is considered silent if it goes undetected and undiagnosed. Each little stroke incapacitates part of the brain. The other type of dementia, Alzheimer's, occurs when a protein substance called beta-amyloid accumulates in critical areas of the brain as a plaque, rather like the cholesterol-laden plaque that builds up in cardiovascular diseases.

This study provides evidence that the health of the arteries and vessels that transport blood to and from your brain is dependent on how well you eat. By extension, it is logical to assume that eating fruits and vegetables will protect against dementia caused by poor vascular health. Research again seems to prove the point

The dementia that is caused by the same vascular problems that lead to stroke is clearly affected by diet. In a publication from the famous Framingham Study, researchers conclude that for every three additional servings of fruits and vegetables a day, the risk of stroke will be reduced by 22%.73

MRI | MedCross Imaging The MedCross Imaging is proud to offer patients and physicians GE 1.5T High-Field MRI. Magnetic Resonance Imaging (MRI) uses magnetism and radio waves to produce remarkably clear pictures of your head, spine, or other parts of your body. Magnetic Resonance Angiography (MRA) is a technique for imaging vascular anatomy and pathology that does not use ionizing radiation.

Second, a huge part of plankton is made up of plants or other organisms that have chlorophyll and produce their own food. As a side effect of this process, the oceans produce 50 percent of the oxygen in the earth’s atmosphere, 95 percent of which comes from phytoplankton and 5 percent from bigger algae (kelp and seaweed) or the few marine vascular plants that live near shore.

According to a large study from Kaiser Permanente, for every 0.05 increase above 4.72, patients had an additional 6 percent increased risk of developing diabetes in the next ten years (4.82 = 12 percent increased risk, etc.) Above 5 indicates that vascular damage has already occurred and a patient is at risk for having damage to the kidneys and eyes. Why is high fasting blood sugar a problem? High blood sugar causes vascular problems throughout your whole body, including your brain. Over time, it causes blood vessels to become brittle and vulnerable to breakage. It leads not only to diabetes but also to heart disease, strokes, visual impairment, impaired wound healing, wrinkled skin, and cognitive problems. Diabetes doubles the risk for Alzheimer’s disease.

Most commonly, hypertensive emergencies occur in the setting of uncontrolled or unknown chronic hypertension. Hypertensive emergencies also may develop as secondary hypertension in association with such diverse etiologies as renal vascular disease, sleep apnea, hyperaldosteronism, pheochromocytoma, and pregnancy (preeclampsia).

These vascular changes, evident to the clinician by examination of the retina, are mirrored by changes in the kidney, leading to a proliferative arteritis, and in advanced stages of the process, fibrinoid necrosis.

Disseminated intravascular coagulation (DIC) Also known as consumptive coagulopathy, this is an acquired disorder of haemostasis (p. 1050); it is common in critically ill patients and often heralds the onset of MOF. It is characterised by an increase in prothrombin time, partial thromboplastin time and fibrin degradation products, and a fall in platelets and fibrinogen. The clinically dominant feature may be widespread bleeding from vascular access points, gastrointestinal tract, bronchial tree and surgical wound sites, or widespread microvascular and even macrovascular thrombosis. Management is supportive with infusions of fresh frozen plasma and platelets, while the underlying cause is treated.

When the lateral roots of two Douglas-firs run into each other underground, they fuse. Through those self-grafted knots, the two trees join their vascular systems together and become one. Networked together underground by countless thousands of miles of living fungal threads, her trees feed and heal each other, keep their young and sick alive, pool their resources and metabolites into community chests. . . . It

The more surplus water there is to be thrown out of the blood, the more sodium sulphate required. All so-called bilious or malarial troubles are simply a chemical effect or action caused by deficient sulphate of soda. Chills and fever are Nature’s method of getting rid of surplus water by squeezing it out of the blood through violent muscular, nervous and vascular spasms. No “shakes” or ague can occur if blood be properly balanced chemically.

Damfield Gardens and Collier's Croft are purpose-built residential care homes located at Maghull and Haydock, near Liverpool in Merseyside. Both care homes come equipped with state-of-the-art-rooms and facilities, and offer 24-hour specialised care for residents with dementia-type illnesses, including lewy bodies, mixed dementia, alzheimers, huntingdon's disease and vascular dementia. We’re immensely proud of our luxurious and stunning residential care home facilities.

Vascular X Muscle Building Vascular X Muscle Building Canada program and whilst you you attend most effort and live a hundred% continuing. This shape of male enhancement works quite for you to physical activities for the remainder of your

It didn’t matter what expressions were on those famous faces at the moment the future erupted from Goettreider’s device—skeptical, awed, distracted, amused, jealous, angry, thoughtful, frightened, detached, concerned, excited, nonchalant, harried, weary, cheeky, or wise—they were all fatally irradiated. Hematopoietic degradation leading to aplastic anemia, irregular cell division, genetic warping, gastrointestinal liquefaction and vascular collapse, catastrophic neurological damage, coma, prayer, death.

Our team eventually identified about 1,100 U.S. churches, synagogues, and mosques that served as vascular screening centers13—despite a scientific consensus that people should not be screened this way for this disease.

Your corpus luteum forms rapidly, and it’s an amazing feat. The tissue grows from virtually nothing to a fully vascularized, 4-centimeter structure in less than one day.

help with cardiovascular issues, try the Zona Plus, a digitally controlled handheld device that uses the science behind isometric exercise to increase both vascular flexibility (thus decreasing blood pressure) and the production and flow of nitric oxide throughout the body, which is linked to treating various cardiovascular conditions, erectile dysfunction, and muscle fatigue.

Considering the time necessary for the effects to show up, we, by analogy with other physiological literature, have observed “conditioning” improvements after a very short training period (1-2 weeks). These short-term changes are rather due to a better neuromuscular and vascular control (a more efficient metabolism, blood flow distribution and use of muscle fibers) than to changes in the muscle structure and will therefore be lost quickly with inactivity. Stable or longer lasting adaptations involve the remodeling of the muscle, such as the enhancement of the mitochondria content or an increase of capillaries, and require, therefore, much longer and continuous training periods.

AN NAD+ BOOSTER BEING TESTED BY THE US SPECIAL FORCES When it comes to boosting NAD+, there may be a new game in town in the next two or three years and it goes by the code name MIB-626. MIB-626 is a proprietary, synthetically manufactured molecule that is similar to, but not identical to NMN. It’s being developed and tested by a company called Metrobiotech that Peter and I have invested in. Historically, when measured, the most NMN has been able to boost NAD+ levels intracellularly has been 40 percent, but recent studies in humans show that fourteen days of dosing with MIB-626 can raise NAD+ levels by as much as 200 to 300 percent! “We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise,” said senior study investigator David Sinclair.

How did nature manage to evolve such complicated architecture? Mandelbrot's point is that the complications exist only in the context of traditional Euclidean geometry. As fractals, branching structures can be described with transparent simplicity, with just a few bits of information. Perhaps the simplest transformations that gave rise to the shapes devised by Koch, Peano, and Sierpinski have their analogue in the coded instructions of an organism's genes. DNA surely cannot specify the vast number of bronchi, bronchioles, and alveoli or the particular spatial structure of the resulting tree, but it can specify a repeating process of bifurcation and development. Such processes suit nature's purposes. When E.I. Dupont de Nemours & Company and the United States Army finally began to produce a synthetic match for goose down, it was by finally realizing that the phenomenal air-trapping ability of the natural product came from the fractal nodes and branches of down's key protein, keratin. Mandelbrot glided matter-of-factly from pulmonary and vascular trees to real botanical trees, trees that need to capture sun and resist wind, with fractal branches and fractal leaves. And theoretical biologists began to speculate that fractal scaling was not just common but universal in morphogenesis. They argued that understanding how such patterns were encoded and processed had become a major challenge to biology.

The current research points to "diet-microbiome interplay" as a cause of vascular disease and perhaps end-organ diseases like heart failure and renal failure and raises the prospect of interventions that "modulate" the microbiome for prevention of heart-failure development and progression.

SAMPLING OF SOME OF THE MAJOR TRIAL RESULTS WITH EDTA CHELATION A 1993analysis of 19 studies of 22,765 patients receiving EDTA chelation therapy for vascular disease found measurable improvement in 87%. A study of 2,870 patients with various degrees of degenerative diseases, especially vascular disease, almost 90% of the patients showed excellent improvement. The study measured walking distance, ECG, and Doppler blood flow changes. A small, blinded, crossover study of patients with peripheral vascular disease found significant improvements in walking distance and ankle/brachial blood flow. In 30 patients with carotid artery stenosis, there was a 30% improvement in blood flow after EDTA treatment. EDTA chelation treatment was evaluated in patients with carotid and coronary disease using technetium 99 isotope techniques. Significant improvement in arterial blood flow and ejection fraction (a measure of heart pumping ability) was reported. 65 patients on the waiting list for CABG surgery for an average of 6 months were treated with EDTA chelation therapy. The symptoms in 89% (58) improved so much they were able to cancel their surgery. In the same study, of 27 patients recommended for limb amputation due to poor peripheral circulation, EDTA chelation saved 24 limbs.

When we cross some threshold of damage, dementia begins to manifest itself. If we’re diabetic and hypertensive, which also means we’re insulin-resistant, we’re going to have more vascular damage and so reach that threshold of damage sooner.

As we become ever more insulin-resistant and glucose-intolerant, as our blood sugar gets higher along with our insulin levels, as our blood pressure elevates and we get ever fatter, we are more likely to be diagnosed as diabetic and manifest the diseases and conditions that associate with diabetes. These include not just heart disease, gout, cancer, Alzheimer’s, and the cluster of Western diseases that Burkitt and Trowell included in their provisional list, but all the conditions typically perceived as complications of diabetes: blood-vessel (vascular) complications that lead to strokes, dementia, and kidney disease; retinopathy (blindness) and cataracts; neuropathies (nerve disorders); plaque deposits in the arteries of the heart (leading to heart attacks) or the legs and feet (leading to amputations); accumulation of advanced glycation end products, AGEs, in the collagen of our skin that can make diabetics look prematurely old, and that in joints, arteries, and the heart and lungs can cause the loss of elasticity as we age. It’s this premature aging of the skin, arteries, and joints that has led some diabetes researchers to think of the disease as a form of accelerated aging. But increasing our risk of contracting all these other chronic conditions means we’re also likely to get these ailments at ever-younger ages and thus, effectively, age faster.