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Disseminated intravascular coagulation (DIC) Also known as consumptive coagulopathy, this is an acquired disorder of haemostasis (p. 1050); it is common in critically ill patients and often heralds the onset of MOF. It is characterised by an increase in prothrombin time, partial thromboplastin time and fibrin degradation products, and a fall in platelets and fibrinogen. The clinically dominant feature may be widespread bleeding from vascular access points, gastrointestinal tract, bronchial tree and surgical wound sites, or widespread microvascular and even macrovascular thrombosis. Management is supportive with infusions of fresh frozen plasma and platelets, while the underlying cause is treated.
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Nicki R. Colledge (Davidson's Principles and Practice of Medicine (MRCP Study Guides))