Tissue Key Quotes

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I've solved the mystery: You have to submit silently. Open up, let go. Let anything penetrate you, even the most painful things. Endure. Bear up. That's the magic key! The text comes by itself, and its meaning shakes the soul ... You mustn't let scar tissue form on your wounds; you have to keep ripping them open in order to turn your insides into a marvelous instrument that is capable of anything. All this has its price.
Klaus Kinski
Once you've seen a solution to the disease that's tearing you apart, relapsing is never fun. You know there's an alternative to the way you're living and that you're going against something you've been given for free by the universe, this key to the kingdom. Drug addiction is a progressive disease, so every time you go out, it gets a little uglier than it was before; it's not like you go back to the early days of using, when there was less of a price to pay. It isn't fun anymore, but it's still desperately exciting. Once you put that first drug or drink in your body, you don't have to worry about the girlfriend or the career or the family or the bills. All those mundane aspects of life disappear. Now you have one job, and that's to keep chucking the coal in the engine, because you don't want this train to stop. If it stops, then you're going to have to feel all that other shit.
Anthony Kiedis (Scar Tissue)
Calvin told me to do something with my brain, but how? Threads of ideas appear on the edge and are gone as soon as my fingers settle on the keys. There's no connective tissue to string them together, no skeleton to hold them up. I want to live my life with the intensity I see on the stage up there, want to feel passionate about something in the same way. But what if it never happens for me?
Christina Lauren (Roomies)
The dreaminess of the night shift is constant, and objects float - keys and coffee cups and Chinese containers and tissues. Time seems free to do what it wants.
Jardine Libaire (White Fur)
I’ve had the thought almost without realizing it—the encroaching awareness that I feel settled but in truth can’t see my future at all. I have a temporary job, a temporary marriage. Will anything ever be permanent? What the hell am I going to do with my life? I only get one shot at this, and right now, I’m finding my value only in being valuable to others. How do I find value for me? Calvin told me to do something with my brain, but how? Threads of ideas appear on the edge and are gone as soon as my fingers settle on the keys. There’s no connective tissue to string them together, no skeleton to hold them up. I want to live my life with the intensity I see on the stage up there, want to feel passionate about something in that same way. But what if it never happens for me?
Christina Lauren (Roomies)
Packing up. The nagging worry of departure. Lost keys, unwritten labels, tissue paper lying on the floor. I hate it all. Even now, when I have done so much of it, when I live, as the saying goes, in my boxes. Even to-day, when shutting drawers and flinging wide a hotel wardrobe, or the impersonal shelves of a furnished villa, is a methodical matter of routine, I am aware of sadness, of a sense of loss. Here, I say, we have lived, we have been happy. This has been ours, however brief the time. Though two nights only have been spent beneath a roof, yet we leave something of ourselves behind. Nothing material, not a hair-pin on a dressing-table, not an empty bottle of aspirin tablets, not a handkerchief beneath a pillow, but something indefinable, a moment of our lives, a thought, a mood.
Daphne du Maurier (Rebecca)
First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so you move less and conserve energy) and hungry (so you eat more), and it slows down your metabolism (so you don’t die!). This “eat less, exercise more” formula is not too successful for most people. It can work for a short time, certainly, but less than 10 percent of people lose weight and keep it off for a year;4 you will almost always rebound and gain back the weight. Second, when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving. The only thing that can stop this vicious cycle is eating a lot of fat and cutting out the refined carbs and sugar. A high-fat, low-carb diet leads to a faster metabolism and sustained weight loss.
Mark Hyman (Eat Fat Get Thin: Why the Fat We Eat Is the Key to Sustained Weight Loss and Vibrant Health)
maintain muscle and other protein-containing tissues. But when you observe a human over a number of weeks of adaptation to a low carbohydrate diet, most of this initial inefficiency in protein use goes away[27]. Thus, once you are keto-adapted, your body’s need for protein isn’t much higher than during a ‘balanced diet’. This is a key fact in our understanding that low carbohydrate diets used in the long term do not need to be particularly high in protein. All the protein we eat (with the exception of stuff that is rubbed or cut off, like skin, hair, and nails) eventually gets burned for energy, yielding 4 Calories per gram. And you can’t “push” your body to build muscle by eating extra protein – muscle is built up under the stimulus of exercise (or illicit pharmaceuticals) as long as adequate protein is available at the time. No one has ever shown
Jeff S. Volek (The Art and Science of Low Carbohydrate Living: An Expert Guide to Making the Life-Saving Benefits of Carbohydrate Restriction Sustainable and Enjoyable)
Yes, man is a physical being. But already, on the first page of the Bible, we learn that man can’t be explained as a merely physical being—a collection of cells, tissues, and organs. Human beings transcend the categories of chemistry and biology. Ultimately, man can only be understood in relation to God. This great mystery of creation—that we are created in God’s image—is the key reference point for understanding all aspects of humanity, including our sexuality.
Pope John Paul II (Theology of the Body in Simple Language)
Can I give you my gift now?” Blake reached in his pocket. “You gave me this already.” Livia wiggled her ring finger. He unfolded the music and held it open for her.“You wrote me a song,” she gasped. “I love it, though you know I can’t read music.” She kissed his lips and held the paper against her heart. “Wait! Oh my gosh. Let me get your gift.” She grabbed a gift bag Kyle had left by the steps. Just before she could hand it to him, she pulled it back. “But what if you hate it? It’s either perfect or horrible. Now I’m worried.” Blake tilted his head and squinted his eyes. “It’s perfect. I’m sure of it. Hand it over.” Livia looked sheepish as he moved the tissue paper out of the way. He unrolled the familiar-shaped cardboard and stared at the keyboard she had painstakingly drawn. Livia tried to cover her worry with words. “I’m not sure if I should have replaced it. I mean, I know nothing could replace it. I tried to get the keys right. I went through like ten boxes and—” Blake could move quickly when he wanted to, and she gasped as he kissed her mid-word. He finally stopped long enough to thank her. “Every time I think I couldn’t love you a bit more, you stretch my heart again.
Debra Anastasia (Poughkeepsie (Poughkeepsie Brotherhood, #1))
Caxtons are mechanical birds with many wings and some are treasured for their markings-- they cause the eyes to melt or the body to shriek without pain. I have never seen one fly, but sometimes they perch on the hand. Mist is when the sky is tired of flight and rests its soft machine on the ground: then the world is dim and bookish like engravings under tissue paper. Rain is when the earth is television. It has the properites of making colours darker. Model T is a room with the lock inside -- a key is turned to free the world for movement, so quick there is a film to watch for anything missed. But time is tied to the wrist or kept in a box, ticking with impatience. In homes, a haunted apparatus sleeps, that snores when you pick it up. If the ghost cries, they carry it to their lips and soothe it to sleep with sounds. And yet, they wake it up deliberately, by tickling with a finger. Only the young are allowed to suffer openly. Adults go to a punishment room with water but nothing to eat. They lock the door and suffer the noises alone. No one is exempt and everyone's pain has a different smell. At night, when all the colours die, they hide in pairs and read about themselves -- in colour, with their eyelids shut.
Craig Raine
I want to hear her laugh. To watch sunbeams awaken her visage and shine through her eyes. To see the gray clouds of regret that hang heavy over her head rain away to nothing. I want to hear her sunny voice dance on the breeze, as light and free as glossy bubbles, floating up…up…up to pop like hiccups. I want to know the type and form of key I must cut to unshackle even a portion of her joy. If I could pluck the winning feather; if my smile could convince; if I could stroke her vocal chords like harp strings and make each treble note ascend to euphoria. Oh, to hear the giggled melody she would release into a world craving the balm of mirth! I ache to experience that. I am desperate for it. I live for the day I hear her laugh.
Richelle E. Goodrich (A Heart Made of Tissue Paper)
Vest" I put on again the vest of many pockets. It is easy to forget which holds the reading glasses, which the small pen, which the house keys, the compass and whistle, the passport. To forget at last for weeks even the pocket holding the day of digging a place for my sister's ashes, the one holding the day where someone will soon enough put my own. To misplace the pocket of touching the walls at Auschwitz would seem impossible. It is not. To misplace, for a decade, the pocket of tears. I rummage and rummage— transfers for Munich, for Melbourne, to Oslo. A receipt for a Singapore kopi. A device holding music: Bach, Garcia, Richter, Porter, Pärt. A woman long dead now gave me, when I told her I could not sing, a kazoo. Now in a pocket. Somewhere, a pocket holding a Steinway. Somewhere, a pocket holding a packet of salt. Borgesian vest, Oxford English Dictionary vest with a magnifying glass tucked inside one snapped-closed pocket, Wikipedia vest, Rosetta vest, Enigma vest of decoding, how is it one person can carry your weight for a lifetime, one person slip into your open arms for a lifetime? Who was given the world, and hunted for tissues, for ChapStick.
Jane Hirshfield (Ledger: Poems)
are out of balance, your life quality diminishes substantially. The hormones estrogen, progesterone, and testosterone make us men and women. Every woman and man has different hormonal requirements. That’s why there is no “one pill fits all” solution. Your hormonal requirements are unique. What you need is different from what I need. This is what hormones “do”; now you might be wondering what they are made of—what they are exactly? A hormone is a chemical substance produced in your body by your glands. They are a complex combination of chemical keys that turn important metabolic locks in our cells, tissues, and organs. All the approximately sixty to ninety trillion cells in our bodies are influenced to some degree by these amazing hormonal keys. The turning on of these “locks” stimulates activity within the cells of our brain, intestines, muscles, genital organs, and skin. As such, hormones determine the rate at which our cells burn up nutrients and other food substances, release energy, and determine whether our cells should produce milk, hair, secretions, enzymes, or some other metabolic (life) product. Hormones affect virtually every function in your body. They affect your mood, how you cope, your sexuality, your sex drive. We all have hormones and without them
Suzanne Somers (I'm Too Young for This!: The Natural Hormone Solution to Enjoy Perimenopause)
When he interviewed Stockdale, Collins asked him, “Who didn’t make it out?” Stockdale replied, “Oh, that’s easy. The optimists.” Stockdale explained that the optimists would believe they’d be out by Christmas, and Christmas would come and go. Then they would believe they’d be out by Easter, and that date would come and go. And the years would tick by like that. He explained to Collins, “They died of a broken heart.” Stockdale told Collins, “This is a very important lesson. You must never confuse faith that you will prevail in the end—which you can never afford to lose—with the discipline to confront the most brutal facts of your current reality, whatever they might be.” We named this third key learning gritty faith and gritty facts, and today we all work to take responsibility for both dreaming and reality-checking those dreams with facts. When stress is high, we can still find ourselves slipping into some of these patterns, especially failing to communicate all of these pieces and to maintain connective tissue. What’s powerful about doing this work is that we now recognize it very quickly and we can name it. Once that happens, we know what rumble needs to happen and why. At the end of the meeting, I apologized for offloading my emotions on them. And, of equal importance, I made a commitment to make good on that apology by
Brené Brown (Dare to Lead: Brave Work. Tough Conversations. Whole Hearts.)
humans have dozens of additional adaptations in our muscles and bones for endurance running whose traces first appear in fossils of H. erectus. Most of these features allow us to use our legs like giant springs to jump efficiently from one leg to another in a manner totally different from walking, which uses the legs like pendulums. As figure 7 shows, when your foot hits the ground during a run, your hips, knees, and ankles flex during the first half of stance, causing your center of mass to drop, thus stretching many of the muscles and tendons in your legs.43 When these tissues stretch, they store up elastic energy, which they release while recoiling during the second half of stance, helping you jump into the air. In fact, a running human’s legs store and release energy so efficiently that running is only about 30 to 50 percent more costly than walking in the endurance-speed range. What’s more, these springs are so effective that they make the cost of human endurance running (but not sprinting) independent of speed: it costs the same number of calories to run five miles at a pace of either 7 or 10 minutes per mile, a phenomenon many people find counterintuitive.44 Since running uses the legs like springs, some of our most important adaptations for running are literally springs. One key spring is the dome-shaped arch of the foot, which develops from the way ligaments and muscles bind together the foot’s bones as children start to walk and run. As discussed
Daniel E. Lieberman (The Story of the Human Body: Evolution, Health and Disease)
REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,
Ray Kurzweil (Fantastic Voyage: Live Long Enough To Live Forever)
Thyroid tissue disorder related to thyroid peroxidase (TPO) autoimmune response:366 TPO is the enzyme in the thyroid responsible for the production of thyroid hormones and is a common site for autoimmune attacks. A positive TPO antibody test suggests Hashimoto’s disease. Nutritional support Regulatory T-cell Support • Emulsified vitamin D and liposomal glutathione and superoxide dismutase cream. TH-1 response or TH-2 response •     Nutritional compounds to support the TH-1 response. Key ingredients include astragalus root extract, echinacea purpurea root, licorice root extract, porcine thymus gland, lemon balm, maitake mushroom, and pomegranate. •     Nutritional compounds to support the TH-2 response. Key ingredients include pine bark extract, grape seed extract, green tea extract, resveratrol, and pycnogenol. Please work with a qualified healthcare practitioner to safely and correctly use these nutrients in the right amounts.
Datis Kharrazian (Why Do I Still Have Thyroid Symptoms? When My Lab Tests Are Normal: A revolutionary breakthrough in understanding Hashimoto's disease and hypothyroidism)
Fat is able to exit your cells primarily through the actions of three enzymes called hormone sensitive lipase (HSL), monoglyceride lipase (MGL), and adipose triglyceride lipase (ATGL). Each of these enzymes are like little ushers that help move fat out of your cellular theater after the show is over. Again, without them, the fat would just stay seated in the cell taking up space. Now, the head usher responsible for the mobilization of free fatty acids from adipose tissue (i.e., lipolysis) is considered to be HSL. It’s more easily acted upon by hormones we can influence (thus the name hormone-sensitive), so, for our enzymatic fat loss communication, that’s where we’re going to put our focus. HSL is an intracellular lipase that has broad substrate specificity (meaning it can break down all kinds of fat). If you watched the cartoon Scooby-Doo when you were younger, you probably remember a time or twenty that someone in the crew had a “skeleton key” that was able to unlock any random door they wanted to get into. While other enzymes are like specialized keys that can break down one type of fat, HSL is like a skeleton key that can open the door to break down many types of fat.
Shawn Stevenson (Eat Smarter: Use the Power of Food to Reboot Your Metabolism, Upgrade Your Brain, and Transform Your Life)
We identified four key learnings during our rumble. First, as a leadership team, we need a shared understanding of all the moving pieces so no single person is the connective tissue. We’ve fixed this with new communication processes that include the team continuing to meet—across all areas of the businesses—when I’m locked away writing, researching, or on the road. We also have a new meeting minutes process. Everyone takes their own notes, but one person in the meeting volunteers to capture minutes.
Brené Brown (Dare to Lead: Brave Work. Tough Conversations. Whole Hearts.)
The sauce is made from the turtle soup stock she made, thickened into a glaze! Poured over the patty, it gives the meat a richer, more full-bodied flavor! "I mixed the turtle's blood in with the patty. It warms the body from the inside out. But that isn't all. I also added dried, powdered tortoise-shell to the patty. Tortoise-shell has long been a prime ingredient in vitality tonics in Chinese medicine." "Both the sauce and the patty are chock-full of turtle everything!" "No wonder the judges look that thoroughly satisfied." "I totally get it! She must've made one incredible burger!" "No. You cannot fully understand. Only those who have tasted this dish can understand its true essence." "What?" "The key to that power lies in the turtle's meat... with the plentiful amounts of gelatin found in it and the sticky sensation that creates!" "Huh?" "Stickiness?" "That is correct, sir. Thick, piping-hot sauce... how thick it is greatly affects the flavor of the dish. The higher the viscosity, the more full-bodied the flavor becomes. Both the burger patty and the sauce I made from turtle stock are filled with gelatin-rich turtle essence. At the back of the roof of the mouth is a collection of soft tissue... called the soft palate. It is one of the most sensitive areas in the entire human body! With every mouthful, the thick, chewy patty and sticky sauce... get pinned between the twin walls of the tongue and the soft palate... stimulating that most sensitive of areas with each seductive bite! In other words, this dish excites not only a person's sense of taste via flavor... ... it also seduces their sense of touch via texture!
Yuto Tsukuda (食戟のソーマ 9 [Shokugeki no Souma 9] (Food Wars: Shokugeki no Soma, #9))
Will anything ever be permanent? What the hell am I going to do with my life? I only get one shot at this, and right now, I’m finding my value only in being valuable to others. How do I find value for me? Calvin told me to do something with my brain, but how? Threads of ideas appear on the edge and are gone as soon as my fingers settle on the keys. There’s no connective tissue to string them together, no skeleton to hold them up. I want to live my life with the intensity I see on the stage up there, want to feel passionate about something in that same way. But what if it never happens for me?
Christina Lauren (Roomies)
The next day, Trump toured Fauci’s lab, the NIH Vaccine Research Center, as part of the White House effort to showcase the president’s determination to speed up the creation of a vaccine. Fauci again reminded Trump that getting a vaccine in a year was wildly optimistic. At the end of the tour, Fauci and Azar drove with the president across Wisconsin Avenue from the NIH campus to the helipad at Walter Reed National Military Medical Center, where Marine One awaited to fly Trump back to the White House. “So how’s Francis Collins doing?” the president asked Azar, referring to the NIH director they had just said goodbye to. “He’s really helped us on the fetal tissue ban,” Azar said. He referred to Trump’s 2019 decision to dramatically cut government funding at NIH and elsewhere for medical research that relied on tissues of aborted fetuses. This was a move to please antiabortion conservatives, a key part of the president’s political base. Collins didn’t agree with the policy, Azar told Trump, but was “being very professional in implementing it.” Azar was surprised when Trump asked, “Is that fetal tissue issue going to slow down the vaccine and therapies?” When he learned the answer was yes, the president said he wanted them to reverse the ban, but that never happened.
Carol Leonnig (I Alone Can Fix It: Donald J. Trump's Catastrophic Final Year)
The key to tooth development is that an interaction between these two layers of tissue, an outer sheet of cells and an inner loose layer of cells, causes the tissue to fold and makes both layers secrete the molecules that build the organ. It turns out that exactly the same process underlies the development of all the structures that develop within skin: scales, hair, feathers, sweat glands, even mammary glands. In each case, two layers come together, fold, and secrete proteins. Indeed, the batteries of the major genetic switches that are active in this process in each kind of tissue are largely similar.
Neil Shubin (Your Inner Fish: a Journey into the 3.5-Billion-Year History of the Human Body)
What is diabetes? The term diabetes refers to a group of diseases that affect the way your body uses blood glucose, commonly called blood sugar. Glucose is vital to your health because it’s the main source of energy for the cells that make up your muscles and tissues. It’s your body’s main source of fuel. If you have diabetes — no matter what type — it means you have too much glucose in your blood, although the reasons why may differ. And too much glucose can lead to serious problems. To understand diabetes, it helps to understand how your body normally processes blood glucose. Processing of blood glucose Blood glucose comes from two major sources: the food you eat and your liver. During digestion, glucose is absorbed into your bloodstream. Normally, it then enters your body’s cells, aided by the action of insulin. The hormone insulin comes from your pancreas. When you eat, your pancreas secretes insulin into your bloodstream. As insulin circulates, it acts like a key, unlocking microscopic doors that allow glucose to enter your cells. In this way, insulin lowers the amount of glucose in your bloodstream and prevents it from reaching high levels. As your blood glucose level drops, so does the secretion of insulin from your pancreas. Your liver acts as a glucose storage and manufacturing center. When the level of insulin in your blood is high, such as after a meal, your liver stores extra glucose as glycogen in case your cells need it later. When your insulin levels are low, for example, when you haven’t eaten in a while, your liver releases the stored glucose into your bloodstream to keep your blood sugar level within a normal range. When you have diabetes If you have diabetes, this process doesn’t work properly. Instead of being transported into your cells, excess glucose builds up in your bloodstream, and eventually some of it is excreted in your urine. This usually occurs when your pancreas produces little or no insulin, or your cells don’t respond properly to insulin, or for both reasons. The medical term for this condition is diabetes mellitus (MEL-lih-tuhs). Mellitus is a Latin word meaning “honey sweet,” referring to the excess sugar in your blood and urine. Another form of diabetes, called diabetes insipidus (in-SIP-uh-dus), is a rare condition in which the kidneys are unable to conserve water, leading to increased urination and excessive thirst. Rather than an insulin problem, diabetes insipidus results from a different hormone disorder. In this book, the term diabetes refers only to diabetes mellitus.
Mayo Clinic (Mayo Clinic Essential Book of Diabetes: How to Prevent, Control, and Live Well with Diabetes)
Human Cloning: The Least Interesting Application of Cloning Technology One of the most powerful methods of applying life’s machinery involves harnessing biology’s own reproductive mechanisms in the form of cloning. Cloning will be a key technology—not for cloning actual humans but for life-extension purposes, in the form of “therapeutic cloning.” This process creates new tissues with “young” telomere-extended and DNA-corrected cells to replace without surgery defective tissues or organs. All responsible ethicists, including myself, consider human cloning at the present time to be unethical. The reasons, however, for me have little to do with the slippery-slope issues of manipulating human life. Rather, the technology today simply does not yet work reliably. The current technique of fusing a cell nucleus from a donor to an egg cell using an electric spark simply causes a high level of genetic errors.57 This is the primary reason that most of the fetuses created by this method do not make it to term. Even those that do make it have genetic defects. Dolly the Sheep developed an obesity problem in adulthood, and the majority of cloned animals produced thus far have had unpredictable health problems.58
Ray Kurzweil (The Singularity is Near: When Humans Transcend Biology)
Like high blood pressure and diabetes, chronic inflammation has no visible symptoms (though it can be measured by a lab test known as high-sensitivity C-reactive protein [hs CRP]). But it damages the vascular system, the organs, the brain, and body tissues. It slowly erodes your health, gradually overwhelming the body’s anti-inflammatory defenses. It causes heart disease. It causes cognitive decline and memory loss. Even obesity and diabetes are linked to inflammation because fat cells are veritable factories for inflammatory chemicals. In fact, it’s likely that inflammation is the key link between obesity and all the diseases obesity puts you at risk for developing. When your joints are chronically inflamed, degenerative diseases like arthritis are right around the corner. Inflamed lungs cause asthma and other respiratory illnesses. Inflammation in the brain is linked to Alzheimer’s disease and other neurological conditions, including brain fog and everyday memory lapses that we write off as normal aging—except those memory lapses are not an inevitable consequence of aging at all. They are, however, an inevitable consequence of inflammation, because inflammation sets your brain on fire. Those “I forgot where I parked the car” moments start happening more frequently, and occurring prematurely. Inflamed arteries can signal the onset of heart disease. Chronic inflammation has also been linked to various forms of cancer; it triggers harmful changes on a molecular level that result in the growth of cancer cells. Inflammation is so central to the process of aging and breakdown at the cellular level that some health pundits have begun referring to the phenomena as “inflam-aging.” That’s because inflammation accelerates aging, including the visible signs of aging we all see in the skin. In addition to making us sick, chronic inflammation can make permanent weight loss fiendishly difficult. The fat cells keep churning out inflammatory proteins called cytokines, promoting even more inflammation. That inflammation in turn prevents the energy-making structures in the cells, called mitochondria, from doing their jobs efficiently, much like a heat wave would affect the output of a factory that lacks air-conditioning—productivity declines under extreme conditions. One of the duties of the mitochondria is burning fat; inflammation interferes with the job of the mitochondria, making fat burning more difficult and fat loss nearly impossible. While someone trying to lose weight may initially be successful, after a while, the number on the scale gets stuck. The much-discussed weight-loss “plateau” is often a result of this cycle of inflammation and fat storage. And here’s even more bad news: Adding more exercise or eating fewer calories in an attempt to break through the plateau will have some effect on weight loss, but not much. And continuing to lose weight becomes much harder to accomplish. Why? Because inflammation decreases our normal ability to burn calories. (We’ll tell you more about other factors that contribute to the plateau—and how the Smart Fat Solution can help you to move beyond them—in Part 2 of this book.)
Steven Masley (Smart Fat: Eat More Fat. Lose More Weight. Get Healthy Now.)
We identified four key learnings during our rumble. First, as a leadership team, we need a shared understanding of all the moving pieces so no single person is the connective tissue.
Brené Brown (Dare to Lead: Brave Work. Tough Conversations. Whole Hearts.)
It was too late to think about that. No time—no time for anything but action as the gate swung back. As Crawford entered behind him. The Colt came out in his hand, a long black shape in the night. He saw his target’s eyes widen, the suppressor almost touching the man’s chest as he pulled the trigger. Once, twice—the .45-caliber hollow-point slugs smashing through bone, body tissue, deforming and expanding outward as they traveled through the body. The young man staggered, but didn’t fall—staring down at the holes in his chest as if it belonged to someone else. Disbelief filling his features. Harry could hear the slide of Crawford’s Sig-Sauer cycling behind him, a deadly cadence. The strangled cry as the older jihadist went down. Taking care of business. He didn’t hesitate, raising the pistol to put a third shot between his target’s eyes, the head snapping back from the impact of the round. No remorse. “Clear.” He glanced back to see Crawford standing over the body of the older man, his pistol aimed down—his finger tightening around the trigger. There was a loud cough, and then the SAS sergeant looked up. “Clear.” Harry keyed his mike, glancing upward toward the building where Hale was providing overwatch. “Bring the Range Rover around and keep it running. We’re going in.
Stephen England (Lodestone (Shadow Warriors #2.6))
With barely controlled patience, then with growing amazement, Sam watched, along with everyone else, as Miss Kent pulled out the broken straps of her suitcase and set them on the table. Then came an overstuffed wallet, a ring of keys that could sink a cargo ship, three packets of airline peanuts, a packet of tissues, an address book, and a candy bar that was squished beyond recognition. She began to mutter softly, her words lost in the cavern of her purse.
Janet Chapman (The Man Must Marry (Sinclair Brothers, #1))
I have to make some signs for tomorrow,” she said, sitting down on the edge of the coffee table as she laced up her sneakers. “I’m going to turn my desk into a store, and let the kids come shopping.” “Yeah?” Jarek found his own shoes and put them on. “What are you selling?” “Oh, the usual. Toothpaste, tissues. Bananas and pencils. Whatever previously learned vocabulary items
Julianna Keyes (Going the Distance)
Take the keys from my bag,’ or ‘There’s a pack of tissues in my bag; you can take those.’ He had not touched a handbag without explicit prior authorisation, more like a command that was only valid for a very limited time. If Laurent couldn’t find the keys or the tissues in less than ten seconds and began to rummage about in the bag, it was immediately reclaimed by its owner. The action was accompanied by an irritated little exclamation, always in the imperative, ‘Give that to me!’ And
Antoine Laurain (The Red Notebook)
ncRNAs have recently been implicated in Lamarckian transmission of inherited characteristics. In one example, fertilised mouse eggs were injected with a miRNA which targeted a key gene involved in growth of heart tissue. The mice which developed from these eggs had enlarged hearts (cardiac hypertrophy) suggesting that the early injection of the miRNA disturbed the normal developmental processes. Remarkably, the offspring of these mice also had a high frequency of cardiac hypertrophy. This was apparently because the abnormal expression of the miRNA was recreated during generation of sperm in these mice. There was no change in the DNA code of the mice, so this was a clear case of a miRNA driving epigenetic inheritance
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
One of the most common uses of early stone tools was to crack open bones in order to get to the marrow. Some researchers believe this was our original niche. Just as woodpeckers specialise in extracting insects from the trunks of trees, the first humans specialised in extracting marrow from bones. Why marrow? Well, suppose you observe a pride of lions take down and devour a giraffe. You wait patiently until they’re done. But it’s still not your turn because first the hyenas and jackals – and you don’t dare interfere with them – scavenge the leftovers. Only then would you and your band dare approach the carcass, look cautiously left and right – and dig into the edible tissue that remained. This is a key
Yuval Noah Harari (Sapiens: A Brief History of Humankind)
A unified Iran is constituted not only politically but also affectively. Liberty and constitutional rule bring "Affection among us." The affective sentiment- that of bonding among differing brothers-produces political bonds of national unity and was associatively linked with other desires. Perhaps foremost was the desire to care for and defend the mother, in particular her bodily integrity. The same words were commonly used to discuss territory and the female body. Laura Mulvey calls these words keys "that could turn either way between the psychoanalytic and the social" (1980, 180). They are not "just words" that open up to either domain; they mediate between these domains, taking power of desire from one to the other. More appropriately, they should be considered cultural nodes of psyhosocial condensation. Tajavuz, literally meaning transgression, expresses both rape and the invasion of territory. Another effective expression, as already noted, was Khak-i pak-i vatan, the pure soil of the homeland. The word used for "pure," pak, is saturated with connotations of sexual purity. Linked to the idea of the purity of a female vatan was the metaphoric notion of the "skirt of chastity" (daman-i 'iffat) and its purity-whether it was stained or not. It was the duty of Iranian men to protect that skirt. The weak and sometimes dying figure of motherland pleaded t her dishonorable sons to arise and cut the hands of foreigners from her skirt. Expressing hope for the success of the new constitutional regime by recalling and wishing away the horrors of previous years, an article in Sur-o Israfil addressed Iran in the following terms: "O Iran! O our Mother! You who have given us milk from the blood of your veins for many long years, and who have fed us with the tissues of your own body! Will we ever live to see your unworthy children entrust your skirt of chastity to the hands of foreigners? Will our eyes ever see foreigners tear away the veil of your chastity?
Afsaneh Najmabadi (Women with Mustaches and Men without Beards: Gender and Sexual Anxieties of Iranian Modernity)
Just as woodpeckers specialise in extracting insects from the trunks of trees, the first humans specialised in extracting marrow from bones. Why marrow? Well, suppose you observe a pride of lions take down and devour a giraffe. You wait patiently until they’re done. But it’s still not your turn because first the hyenas and jackals – and you don’t dare interfere with them – scavenge the leftovers. Only then would you and your band dare approach the carcass, look cautiously left and right – and dig into the edible tissue that remained. This is a key to understanding our history and psychology. Genus Homo’s position in the food chain was, until quite recently, solidly in the middle. For millions of years, humans hunted smaller creatures and gathered what they could, all the while being hunted by larger predators. It was only 400,000 years ago that several species of man began to hunt large game on a regular basis, and only in the last 100,000 years – with the rise of Homo sapiens – that man jumped to the top of the food chain. That spectacular leap from the middle to the top had enormous consequences. Other animals at the top of the pyramid, such as lions and sharks, evolved into that position very gradually, over millions of years. This enabled the ecosystem to develop checks and balances that prevent lions and sharks from wreaking too much havoc. As lions became deadlier, so gazelles evolved to run faster, hyenas to cooperate better, and rhinoceroses to be more bad-tempered. In contrast, humankind ascended to the top so quickly that the ecosystem was not given time to adjust. Moreover, humans themselves failed to adjust. Most top predators of the planet are majestic creatures. Millions of years of dominion have filled them with self-confidence. Sapiens by contrast is more like a banana-republic dictator. Having so recently been one of the underdogs of the savannah, we are full of fears and anxieties over our position, which makes us doubly cruel and dangerous. Many historical calamities, from deadly wars to ecological catastrophes, have resulted from this over-hasty jump.
Yuval Noah Harari (Sapiens: A Brief History of Humankind)
Effect On Culture Organizations are made up of people. Those people work and “live” there with other people at least 40 hours per week. Like the connective tissue that begins to form when we are injured or when we are healing and becomes a part of who we are, team members are a part of the connective tissue of the organization. What happens when we remove or tear out a piece of that tissue? Not only does it hurt a lot, it causes heavy bleeding. If it doesn’t heal properly, there are complications. We may never regain our function in that area. When good productive people leave, we feel the pain and so does the culture of the team. The only way to mend the tissue permanently is to do the right things to engage and retain them. Spillover Effect We don’t talk about this much, but there is a psychological impact on other productive and engaged employees when they are forced to work with disengaged employees. Whether it is during water cooler talk or just in combined work spaces, the negative energy that disengaged employees pass to the entire team and organization can be toxic. Oftentimes, the disengaged employees are the scapegoats to deeper organizational issues. When we do not look at what is causing them to be disengaged, we enable the spillover effect to continue. Organizations that want a thriving workplace must rid themselves of disengaged employees, not necessarily by termination, but by living by the Laws found in this book. Negative Word Of Mouth Remember that unhappy employees don’t make for good promoters of your brand. In fact, disengaged employees are likely to tell more people and blurt it out all over social media and at every party. Reputationally, this negative word of mouth works against your brand promise. Who are you out in the world to your customers? Whatever that is, it must match who you are to your employees. Loss Of Organizational Stability Stop for a minute and think about what it says to your customers, partners, and investors when your employees keep walking out the door. Potentially, they could be in the middle of a complex project implementation and having a consistent point of contact through that process is key.
Heather R. Younger (The 7 Intuitive Laws of Employee Loyalty: Fascinating Truths About What It Takes to Create Truly Loyal and Engaged Employees)
when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving.
Mark Hyman (Eat Fat, Get Thin: Why the Fat We Eat Is the Key to Sustained Weight Loss and Vibrant Health)
The reason many people gain weight as they age, especially beginning in their 30s, is because they have less muscle than they had in their late teens and early twenties. As we age, our bodies naturally lose muscle, especially as we are less active in our lives. This muscle tissue loss results in a decreasing metabolic rate. And then, if you continue to eat like you did when you were younger … well, you’ll slowly gain weight, pound by pound, month by month, year by year, until one day you look in the mirror and wonder, “What happened?” This is how the average American adult gains 2.2 pounds per year. The key to eliminating accumulated body fat is regaining your youthful metabolism by regaining your muscle through strength training.
Mark Lauren (You Are Your Own Gym: The Bible of Bodyweight Exercises)
As soon as possible, following your workout you need to consume: • 30 – 50 grams of a lean complete protein like whey, soy, egg, chicken or fish. • 30 – 50 grams of carbohydrates with a high glycemic index. Why lean protein? Because fat slows the absorption of protein and carbs. During a brief window of opportunity after your workout, protein synthesis occurs at the highest rate. This is due to the micro-trauma (broken-down muscle tissue) that occurred during your workout. Complete recovery will be optimized if you provide your muscles with a large supply of amino acids—the key components of protein—within 45 minutes after your training session. A whey protein shake is the best post-workout protein choice because it is so rapidly absorbed, and it has the highest efficiency ratio, or availability to the body, of all proteins. Why carbs with a high glycemic index? Immediately following your workout is the only time to eat carbs that rapidly absorb into the blood stream as the glucose causes an insulin spike. Insulin helps shuttle protein into the muscles, repairing and building new muscle. It is also an important hormone that regulates the storage, replacement, and use of glucose. During a workout, the body uses stored glucose that is in the blood and muscles as fuel for the activity. If the lost glucose isn’t refilled within about 45 minutes after training, your body rapidly goes from an anabolic state (muscle growth and repair) to a catabolic state (cannibalizing of the body’s muscle for protein and energy). Since insulin signals the body to replenish and store glycogen, and the release of insulin is best triggered by eating foods with a high glycemic index, it makes sense that eating carbohydrates with a high glycemic index, along with some lean protein, is the best post-workout choice. An effective and convenient post workout meal is a whey or soy protein supplement, which contains maltodextrin, or simple sugars, as its carb source.
Mark Lauren (You Are Your Own Gym: The Bible of Bodyweight Exercises)