Tissue Engineering Quotes

Once you've seen a solution to the disease that's tearing you apart, relapsing is never fun. You know there's an alternative to the way you're living and that you're going against something you've been given for free by the universe, this key to the kingdom. Drug addiction is a progressive disease, so every time you go out, it gets a little uglier than it was before; it's not like you go back to the early days of using, when there was less of a price to pay. It isn't fun anymore, but it's still desperately exciting. Once you put that first drug or drink in your body, you don't have to worry about the girlfriend or the career or the family or the bills. All those mundane aspects of life disappear. Now you have one job, and that's to keep chucking the coal in the engine, because you don't want this train to stop. If it stops, then you're going to have to feel all that other shit.

She was designed to look human, her face the replica of a woman whose image Med’s tissue engineer had licensed from an old Facebook database.

Any discussion of the sexuality of the digestive tract must inevitably touch on the anus. Anal tissue is among the most densely innervated on the human body. It has to be. It requires a lot of information to do its job. The anus has to be able to tell what’s knocking at its door: Is it solid, liquid, or gas? And then selectively release either all of it or one part of it. The consequences of a misread are dire. As Mike Jones put it, “You don’t want to choose poorly.” People who understand anatomy are often cowed by the feats of the lowly anus. “Think of it,” said Robert Rosenbluth, a physician whose acquaintance I made at the start of this book. “No engineer could design something as multifunctional and fine-tuned as an anus. To call someone an asshole is really bragging him up.

So far modern medicine hasn’t extended our natural life span by a single year. Its great achievement has been to save us from premature death, and allow us to enjoy the full measure of our years. Even if we now overcome cancer, diabetes and the other major killers, it would mean only that almost everyone will get to live to ninety – but it will not be enough to reach 150, let alone 500. For that, medicine will need to re-engineer the most fundamental structures and processes of the human body, and discover how to regenerate organs and tissues.

The revolution caused by the sharing of experience and the spread of knowledge had begun. The Chinese, a thousand years ago, gave it further impetus by devising mechanical means of reproducing such marks in great numbers. In Europe, Johann Gutenberg independently, though much later, developed the technique of printing from movable type. Today, our libraries, the descendants of those mud tablets, can be regarded as immense communal brains, memorising far more than any one human brain could hold. More than that, they can be seen as extra-corporeal DNA, adjuncts to our genetic inheritance as important and influential in determining the way we behave as the chromosomes in our tissues are in determining the physical shape of our bodies. It was this accumulated wisdom that eventually enabled us to devise ways of escaping the dictates of the environment. Our knowledge of agricultural techniques and mechanical devices, of medicine and engineering, of mathematics and space travel, all depend on stored experience. Cut off from our libraries and all they represent and marooned on a desert island, any one of us would be quickly reduced to the life of a hunter-gatherer.

Drug addiction is a progressive disease, so every time you go out, it gets a little uglier than it was before; it’s not like you go back to the early days of using, when there was less of a price to pay. It isn’t fun anymore, but it’s still desperately exciting. Once you put that first drug or drink in your body, you don’t have to worry about the girlfriend or the career or the family or the bills. All those mundane aspects of life disappear. Now you have one job, and that’s to keep chucking the coal in the engine, because you don’t want this train to stop. If it stops, then you’re going to have to feel all that other shit.

Finally, Tononi argues that the neural correlate of consciousness in the human brain resembles a grid-like structure. One of the most robust findings in neuroscience is how visual, auditory, and touch perceptual spaces map in a topographic manner onto visual, auditory, and somatosensory cortices. Most excitatory pyramidal cells and inhibitory interneurons have local axons strongly connected to their immediate neighbours, with the connections probability decreasing with distance. Topographically organized cortical tissue, whether it develops naturally inside the skull or is engineered out of stem cells and grown in dishes, will have high intrinsic causal power. This tissue will feel like something, even if our intuition revels at the thought that cortical carpets, disconnected from all their inputs and outputs, can experience anything. But this is precisely what happens to each one of us when we close our eyes, go to sleep, and dream. We create a world that feels as real as the awake one, while devoid of sensory input and unable to move. Cerebral organoids or grid-like substances will not be conscious of love or hate, but of space.; of up, down, close by and far away and other spatial phenomenology distinctions. But unless provided with sophisticated motor outputs, they will be unable to do anything.

While there was still water in the middle of the pools, animals attempted to reach it through the silt but would get bogged. We spent day after day checking dams, finding about eight to ten animals hopelessly mired in the silt at each and every dam, primarily kangaroos and wallabies. We had to get to the dams early in the morning. Some of the kangaroos had been struggling all night. Steve engineered planks and straps to rescue the animals. The silt would suck us down just as fast, so we had to be careful going out to rescue the roos. Because of the lactic acid buildup in their tissues (a product of their all-night exertions to free themselves), some of the kangaroos were too far gone and couldn’t recover. But we saved quite a few. At one point, Bob came out to lend a hand. I was at the homestead, and the ovulation strip turned bright blue. I hustled over to the creek bed where Steve and his dad were working. I motioned to Steve. “The strip is blue,” I said. He looked around nervously. “I’m out here working with me dad,” he said. “What do you want me to do?” “Just come on,” I whispered impatiently. “But my dad’s right here!” I smiled and took his hand. We headed up the dry creek bed and spent some quality time with the biting ants and the prickles. It was after this trip to our conservation property in the Brigalow Belt that I discovered I was pregnant. I tried to let Steve know by sitting down at the table and tucking into a bowl of ice cream and pickles. “What are you doing?” asked a totally confused Steve. I explained, and we were both totally overjoyed, keeping our fingers crossed for a boy to go along with our darling daughter.

Our ability to arrange atoms lies at the foundation of technology. We have come far in our atom arranging, from chipping flint for arrowheads to machining aluminum for spaceships. We take pride in our technology, with our lifesaving drugs and desktop computers. Yet our spacecraft are still crude, our computers are still stupid, and the molecules in our tissues still slide into disorder, first destroying health, then life itself. For all our advances in arranging atoms, we still use primitive methods. With our present technology, we are still forced to handle atoms in unruly herds. But the laws of nature leave plenty of room for progress, and the pressures of world competition are even now pushing us forward. For better or for worse, the greatest technological breakthrough in history is still to come. —ERIC DREXLER, ENGINES OF CREATION:THE COMING ERA OF NANOTECHNOLOGY, 1986

No doctor has the power to cause blood to clot or tissue or bone to regenerate or tumors to shrink. We don’t create, only prompt biological functions to work or not work properly on their own, and in that regard, doctors are more limited than a mechanic or an engineer who actually builds something out of nothing

We had finished the set when a lovely young woman wandered into our dressing room. She had bleached-blond hair and fire-engine-red lips and giant eyelashes that made her look like a reincarnated southern version of Marilyn Monroe. As I was prone to do at that time, I made my move before anyone else could even talk to her. I grabbed her hand and pulled her into the bathroom and asked her if she could keep me company while I took a shower. Once I got into the shower, she went into an impeccable rendition of Marilyn singing "Happy Birthday" to JFK. I got out of that shower ready to go. She immediately threw off her clothes and we made love on the floor. I had known the girl for five minutes, but I was certain of my affection for her. We spent the night together, and I found out more about her, including the fact that she went to Catholic school. (She would be the inspiration for a later song, "Catholic School Girls Rule.") The next day we drove to Baton Rouge, and of course, she came with us. After we got offstage, she came up to me and said, "I have something to tell you. My father's the chief of police and the entire state of Louisiana is looking for me because I've gone missing. Oh, and besides that, I'm only fourteen." I wasn't incredibly scared, because in my somewhat deluded mind, I knew that if she told the chief of police she was in love with me, he wasn't going to have me taken out to a field and shot, but I did want to get her the hell back home right away. So we had sex one more time, and she gave me an interesting compliment that I never forgot. She said, "When you make love to me, it's like you're a professional." I told her that she should give herself a little time and she'd realize that it was because she didn't have much to compare it to. And I put her on a bus and sent her back to New Orleans.

Every multicellular organism begins as one cell, which contains all of the intricate instructions to synthesize, organize, and regulate not only this cell but the development and maintenance of all cells that will inevitably comprise the organism. All of these instructions are encoded in the first cell's DNA. This underscores the complexity of the genome and how each cell's expression must be controlled in specific ways depending on its function. The cells hailing from each tissue in the human body (e.g., muscle, lung, heart, liver) harbor a unique epigen­etic signature, which enables the maintenance of tissue-specific func­tions through the control of gene regulation, as just discussed. "Our knowledge of the total number of unique cells, or cell types, is still growing. Previous estimates put the number of unique cell types in the human body at ~300, but new estimates from the Human Cell Atlas have shown that we may have thousands of cell types and subtypes, each harboring a unique function for a specific physiological state or response to stimuli. But even cells of the same cell type will not be identical. A cell's 'presentation' of molecules on their surface can radi­cally change depending on internal variables such as genetic mutations or altered states of their epigenome, transcriptome, and proteome, as well as external stimuli including drugs and interactions with other cells. This novel presentation is most pronounced with a neoantigen, when a cancer cell creates an entirely new molecule on the surface of a cell. Given its unique presentation, which wouldn't be found in nor­mal cells, this offers a unique target for safer cancer therapies. "The human body has about 30 trillion human cells plus another 30-40 trillion bacterial cells, for a total of about 70 trillion cells. If your body were a democracy, the human cells would often be the minority or equal party. You (as a human) would never win an election. Your loss of control would likely result in you rolling around in the soil or lying in a bathtub full of yogurt, which I do sometimes on Sundays. Regard­less of how you spend your Sundays, there are a lot of microbes in, on, and around your body. There are in fact so many microbes that they compose the bulk of the cells on Earth. This is a humbling and exciting statistic, and one which is vividly apparent for anyone who has ever had explosive diarrhea.

HOW TO KILL YOUR BEST FRIEND Method 4: Electrocution Hair dryer dropped in a bath tub? I suppose it's just about believable and I could probably engineer such a situation. But I Googled it (not on my own device, of course), and it seems that it's actually very unlikely to be fatal. Electricity is lazy; it seeks the path of least resistance. The current will almost certainly run to ground through the bathwater and the bath plug, rather than through the cardiac tissue, meaning that the only thing that gets successfully fried is the bath salts. How else can you engender a fatal electrocution? With difficulty, according to the Google search results. There are too many variables. AC or DC current. Wet or dry hands. The material of the shoes the person is wearing. Whether the current finds a way to breach the skin to reach the soft, vulnerable, unresistant tissues inside-and how much water and how much fat are in those tissues. The more I look at this, the more I realize how exceedingly difficult it is to kill a person-without immediately getting caught, I mean. Which is, ordinarily, a good thing, one supposes. Though not much help to me now.

P2 - We are well on the way in a number of areas. Both billionaires and big Pharma are getting increasingly interested and money is starting to pour into research because it is clear we can see the light at the end of the tunnel which to investors equates to return on investment. Numerous factors will drive things forward and interest and awareness is increasing rapidly among both scientists, researchers and the general population as well as wealthy philanthropists. The greatest driving force of all is that the baby boomers are aging and this will place increasing demands on healthcare systems. Keep in mind that the average person costs more in medical expenditure in the last year of their life than all the other years put together. Also, the number of workers is declining in most developed countries which means that we need to keep the existing population working and productive as long as possible. Below are a list which are basically all technologies potentially leading to radical life extension with number 5 highlighted which I assume might well be possible in the second half of the century: 1. Biotechnology - e.g stem cell therapies, enhanced autophagy, pharmaceuticals, immunotherapies, etc 2. Nanotechnology - Methods of repairing the body at a cellular and molecular level such as nanobots. 3. Robotics - This could lead to the replacement of increasing numbers of body parts and tends to go hand in hand with AI and whole brain emulation. It can be argued that this is not life extension and that it is a path toward becoming a Cyborg but I don’t share that view because even today we don’t view a quadriplegic as less human if he has four bionic limbs and this will hold true as our technology progresses. 4. Gene Therapies - These could be classified under the first category but I prefer to look at it separately as it could impact the function of the body in very dramatic ways which would suppress genes that negatively impact us and enhance genes which increase our tendency toward longer and healthier lives. 5. Whole brain emulation and mindscaping - This is in effect mind transfer to a non biological host although it could equally apply to uploading the brain to a new biological brain created via tissue engineering this has the drawback that if the original brain continues to exist the second brain would have a separate existence in other words whilst you are identical at the time of upload increasing divergence over time will be inevitable but it means the consciousness could never die provided it is appropriately backed up. So what is the chance of success with any of these? My answer is that in order for us to fail to achieve radical life extension by the middle of the century requires that all of the above technologies must also fail to progress which simply won't happen and considering the current rate of development which is accelerating exponentially and then factoring in that only one or two of the above are needed to achieve life extension (although the end results would differ greatly) frankly I can’t see how we can fail to make enough progress within 10-20 years to add at least 20 to 30 years to current life expectancy from which point progress will rapidly accelerate due to increased funding turning aging at the very least into a manageable albeit a chronic incurable condition until the turn of the 22nd century. We must also factor in that there is also a possibility that we could find a faster route if a few more technologies like CRISPR were to be developed. Were that to happen things could move forward very rapidly. In the short term I'm confident that we will achieve significant positive results within a year or two in research on mice and that the knowledge acquired will then be transferred to humans within around a decade. According to ADG, a dystopian version of the post-aging world like in the film 'In Time' not plausible in the real world: "If you CAREFULLY watch just the first

As their expanded name suggests, EMI wasn’t only a record label. In the 1960s the company was as interesting for its electrical activities as for its musical ones. In 1959 it had launched a commercial computer called the EMIDEC 1100; it also made color TV cameras, recording equipment, guided missiles, and kettles. The piles of cash brought in by Beatlemania helped create a culture of investment at EMI. One of the things they invested in was medical equipment research. Godfrey Hounsfield, the researcher behind the EMIDEC, began work on the first commercially viable medical scanner. As the project developed, he was significantly supported by the UK government, which provided over £600,000 of support or £7 million at 2016 prices (Maizlin and Vos 2012). Over four years, he and his team invented and built the first computed tomography scanner (CT or “CAT scanner”—the A stands for “axial”). This was a remarkable feat of science and engineering. For the first time, it allowed doctors to make accurate, 3D representations of patients’ soft tissues. This was a real medical breakthrough, transforming everything from brain surgery to cancer treatment. Hounsfield was piled with honors: he received a Nobel prize and a knighthood and was made a Fellow of the Royal Society. But from a commercial point of view, it was something of a failure for EMI.

ChiroCynergy - Dr. Matthew Bradshaw | Active Release Technique (A.R.T.) in Leland, NC What exactly is Active Release Technique (A.R.T.)? ART is a patented, state-of-the-art, soft tissue management system developed by Dr. Michael Leahy (an Air Force engineer/chiropractor) that treats problems occurring with: - Muscles - Tendons - Ligaments - Fascia - Nerves Injuries to these tissues can occur in 3 different ways: Acute trauma injury – a sprained ankle playing racquetball is a great example of this type of injury. Compression injury – an example of a compression injury would be back stiffness and pain and/or numbness down the leg (sciatica) caused by sitting behind a computer frequently and for long periods of time. Sitting causes reduced oxygen flow to the tissues, which in turn causes the numbness and/or pain. Overuse injuries – frequently seen in people whose jobs involve typing all day. The repetitive motion can produce wrist and hand pain (i.e. carpal tall syndrome) due to the accumulation of small tears in the tissues. Each of these changes causes your body to produce tough, dense scar tissue in the affected area. This scar tissue binds up and ties down tissues that need to move freely. As scar tissue builds up: Muscles become shorter and weaker. Tension on tendons causes tendonitis. Nerves can become trapped. This can result in reduced ranges of motion, loss of strength, and pain. With trapped nerves, you may also feel tingling, numbness, shooting pains, burning sensations, weakness, muscle atrophy and circulatory changes. Even when most doctors say medications or surgery is the only answer, ART may still be able to resolve the symptoms and put you back on the field or back to work and into your best game. ChiroCynergy can help! We offer Active Release Technique (A.R.T.) in Leland, NC. Call us: (910) 368-1528 #chiropractor_Leland_nc #best_chiropractor_Leland_nc #chiropractor_near_Leland_nc #chiropractic_in_Leland_nc #best_chiropractor_in_Leland_nc #chiropractic_near_me #chiropractor_near_me #family_chiropractor_in_Leland_nc #female_chiropractors_in_Leland_nc #physical_therapy_in_Leland_nc #sports_chiropractor_in_Leland_nc #pregnancy_chiropractor_in_Leland_nc #sciatica_chiropractor_in_Leland_nc #car_accident_chiropractor_in_Leland_nc #Active_Release_Technique_in_Leland_nc #Cold_Laser_Therapy_in_Leland_nc #Spinal_Decompression_in_Leland_nc