Short Pathways Quotes

As a consequence of the enormous social and technological changes of the last few centuries, the world is not working well. We do not live in traditional and static societies. But our government, in resisting change, act as if we did. Unless we destroy ourselves utterly, the future belongs to those societies that, while not ignoring the reptilian and mammalian parts of our being, enable the characteristically human components of our nature to flourish; to those societies that encourage diversity rather than conformity; to those societies willing to invest resources in a variety of social, political, economic and cultural experiments, and prepared to sacrifice short-term advantage for long-term benefit; to those societies that treat new ideas as delicate, fragile and immensely valuable pathways to the future.

Sometimes the journey is too long; sometimes it is too short. Sometimes too lonely; sometimes too difficult. But God's love is your resting place and anchor; His light your pathway.

It was. What sadness lengthens Romeo’s hours? ROMEO: Not having that, which, having, makes them short. BENVOLIO: In love? ROMEO: Out— BENVOLIO: Of love? ROMEO: Out of her favour, where I am in love. BENVOLIO: Alas, that love, so gentle in his view, Should be so tyrannous and rough in proof! ROMEO: Alas, that love, whose view is muffled still, Should, without eyes, see pathways to his will!

Curiosity is unruly. It doesn’t like rules, or, at least, it assumes that all rules are provisional, subject to the laceration of a smart question nobody has yet thought to ask. It disdains the approved pathways, preferring diversions, unplanned excursions, impulsive left turns. In short, curiosity is deviant.

There’s a reason for this. Curiosity is unruly. It doesn’t like rules, or at least, it assumes that all rules are provisional, subject to the laceration of a smart question nobody has yet thought to ask. It disdains the approved pathways, preferring diversions, unplanned excursions, impulsive left turns. In short, curiosity is deviant. Pursuing it is liable to bring you into conflict with authority at some point, as everyone from Galileo to Charles Darwin to Steve Jobs could have attested.

The full moon, sailing across an unclouded sky, made a pathway on the broad sea that led to the boundless realms of Forever.

see...'Reflections are but another aspect of a man, and need only an invitation and an anchor to open the pathways between worlds.

It is possible, I think as I sit there on the cold wood of the bandstand bench, to see ailing marriages as brains that have undergone a stroke. Certain connections short-circuit, abilities are lost, cognition suffers, a thousand neural pathways close down forever. Some strokes are massive, seminal, unignorable; others imperceptible. I’m told it’s perfectly possible to suffer one and not realize it until much later.

Curiosity is a shit-starter. But that’s okay. Sometimes we have to rumble with a story to find the truth. In his book Curious: The Desire to Know and Why Your Future Depends on It, Ian Leslie writes, “Curiosity is unruly. It doesn’t like rules, or, at least, it assumes that all rules are provisional, subject to the laceration of a smart question nobody has yet thought to ask. It disdains the approved pathways, preferring diversions, unplanned excursions, impulsive left turns. In short, curiosity is deviant.

The children left him and ran. A pathway led up through the close sapling oaks, and almost at the top of the ascent they encountered Mrs. Lewarne—Linnet. She too had a basket on her arm. Now Johnny might believe in fairies and suchlike, but to Mary Mrs. Lewarne was a vision of all things desirable in grown-up life—beauty, grace, carriage, a sweet commanding voice, the true accent, clothes, and all delicate appanages of wealth—everything in short that her own little soul aspired after. And yet not too proud to carry a basket!

There may be a genetic basis to how much dopamine each of our brains produces. The gene that codes for the production of dopamine is called DRD4 (dopamine receptor D4) and is located on the short arm of the eleventh chromosome. When dopamine is released by certain neurons in the brain it is picked up by other neurons that are receptive to its chemical structure, thereby establishing dopamine pathways that stimulate organisms to become more active and reward certain behaviors that then get repeated. If you knock out dopamine from either a rat or a human, for example, they will become catatonic. If you overstimulate the production of dopamine, you get frenetic behavior in rats and schizophrenic behavior in humans.

Before running into the ocean, we’d put our hands to the sky, say a short prayer and take three very deep breaths, before proceeding to run in, whooping like the children we are at heart. Greg also taught me that when you’re coming out of the water you should raise your hands to the sky and say thank you, to show gratitude for everything you have in your life. Greg told me that Einstein had appeared to him in a dream, saying that walking backwards off the beach would create new neural pathways. So we always walked backwards off the beach, keeping our eyes on the ocean, picking up pieces of littered plastic along the way. “Try to leave every environment better than when you found it,” he told me.

You must also know clearly what you want out of the situation, and be prepared to clearly articulate your desire. It’s a good idea to tell the person you are confronting exactly what you would like them to do instead of what they have done or currently are doing. You might think, “if they loved me, they would know what to do.” That’s the voice of resentment. Assume ignorance before malevolence. No one has a direct pipeline to your wants and needs—not even you. If you try to determine exactly what you want, you might find that it is more difficult than you think. The person oppressing you is likely no wiser than you, especially about you. Tell them directly what would be preferable, instead, after you have sorted it out. Make your request as small and reasonable as possible—but ensure that its fulfillment would satisfy you. In that manner, you come to the discussion with a solution, instead of just a problem. Agreeable, compassionate, empathic, conflict-averse people (all those traits group together) let people walk on them, and they get bitter. They sacrifice themselves for others, sometimes excessively, and cannot comprehend why that is not reciprocated. Agreeable people are compliant, and this robs them of their independence. The danger associated with this can be amplified by high trait neuroticism. Agreeable people will go along with whoever makes a suggestion, instead of insisting, at least sometimes, on their own way. So, they lose their way, and become indecisive and too easily swayed. If they are, in addition, easily frightened and hurt, they have even less reason to strike out on their own, as doing so exposes them to threat and danger (at least in the short term). That’s the pathway to dependent personality disorder, technically speaking.198 It might be regarded as the polar opposite of antisocial personality disorder, the set of traits characteristic of delinquency in childhood and adolescence and criminality in adulthood. It would be lovely if the opposite of a criminal was a saint—but it’s not the case. The opposite of a criminal is an Oedipal mother, which is its own type of criminal.

WHEN RELIGION CANNOT KNEEL Aristotle said democracy would only work in a culture already committed to virtue. There is no communal myth left that teaches us the essentially tragic nature of human life; there is no vision that proclaims the primacy of the common good; there is no transcendent image that makes human virtue a divine reflection. There is No One to reflect and No One to love and serve. I do not want to belong to a religion that cannot kneel. I do not want to live in a world where there is No One to adore. It is a lonely and labored world if I am its only center. My life is too short to discover wisdom on my own, to identify and properly name my own self-importance, to learn how to love if I have to start at zero.

Where are we going?” Arin stared out the carriage window at the trees of the Garden District, their bare branches slim and violet in the dusk. Kestrel fidgeted with her skirts. “Arin. You know that we are going to Irex’s party.” “Yes,” he said shortly, but didn’t tear his gaze away from the passing trees. Better he look at them than at her. The velvet dress was a deep red, the skirts deliberately crushed in a pattern highlighted by golden embroidered leaves that twined up toward the bodice, where they interlaced and would catch the light. Conspicuous. The dress made her conspicuous. Kestrel sank into her corner of the carriage, feeling her dagger dig into her side. This evening at Irex’s wouldn’t be easy. Arin seemed to think the same. He held himself so rigidly on the carriage seat across from her that he looked wooden. Tension seeped into the air between them. When torches lit the darkness outside the windows and the driver lined up behind other carriage waiting to access the pathway to Irex’s villa, Kestrel said, “Perhaps we should return home.” “No,” said Arin. “I want to see the house.” He opened the door. They were silent as they walked up the path to the villa. Though not as large as Kestrel’s, it was also a former Herrani home: elegant, prettily designed. Arin fell behind Kestrel, as was expected of slaves, but this made her uneasy. It was unsettling to feel him close and not see his face. They entered the house with the other guests and made their way into the receiving room, which was lined with Valorian weapons. “They don’t belong there,” she heard Arin say. She turned to see him staring in shock at the walls. “Irex is an exceptional fighter,” said Kestrel. “And not very modest.” Arin said nothing, so neither did Kestrel.

They reached the eastern outskirts of the Dimmerskog on the afternoon of the next day. Although the forest was covered in a thick blanket of white snow, it nevertheless seemed, as Binabik had named it, a place of shadows. The company did not pass beneath its eaves, and might have chosen not to even had their path lain that way, so thick with foreboding was the wood’s atmosphere. The trees, despite their size—and some of them were huge indeed—seemed dwarfish and twisted, as though they squirmed bitterly beneath their burden of needled branches and snow. The open spaces between the contorted trunks seemed to bend away crazily like tunnels dug by some huge and drunken mole, leading at last to dangerous, secretive depths. Passing in near silence, his horse’s hooves crunching softly in the snow, Simon imagined following the gaping pathways into the bark-pillared, white-roofed halls of Dimmerskog, coming at last to—who could guess? Perhaps to the dark, malicious heart of the forest, a place where the trees breathed together and passed endless rumors with the scaly rub of branch on branch, or the malicious exhalation of wind through twigs and frozen leaves. They camped that night in the open again, even though the Dimmerskog crouched only a short distance away like a sleeping animal. None of them wanted to spend a night beneath the forest’s branches—especially Sludig, who had been raised on stories of the ghastly things that stalked the wood’s pale corridors. The Sithi did not seem to care, but Jiriki spent part of the evening oiling his dark witchwood sword. Again the company huddled around a naked fire, and the east wind razored past them all the long evening, sending great powdery spouts of snow whirling all around, and sporting among the Dimmerskog’s upper reaches. When they lay down that night to sleep it was to the sound of the forest creaking, and the wind-ridden branches sawing one against the other.

For years, exercise scientists have been convinced that the only way to increase mitochondrial density is with aerobic endurance training, but recent studies have proved otherwise. Not only is an increase in the size and number of mitochondria a proven adaptation to HIIT, but the mitochondrial benefit of HIIT goes way beyond size and number. For example, all your mitochondria contain oxidative enzymes, such as citrate synthase, malate dehydrogenase, and succinate dehydrogenase. These oxidative enzymes lead to improved metabolic function of your skeletal muscles—particularly by causing more effective fat and carbohydrate breakdown for fuel and also by accelerating energy formation from ATP. So more oxidative enzymes means that you have a higher capacity for going longer and harder. And it turns out that, according to an initial study on the effect of HIIT on oxidative enzymes, there were enormous increases in skeletal muscle oxidative enzymes in seven weeks in subjects who did four to ten thirty-second maximal cycling sprints followed by four minutes of recovery just three days a week. But what about HIIT as opposed to aerobic cardio? Another six-week training study compared the increase in oxidative enzymes that resulted from either: 1. Four to six thirty-second maximal-effort cycling sprints, each followed by four-and-a-half minutes of recovery, performed three days a week (classic HIIT training) or 2. Forty to sixty minutes of steady cycling at 65 percent VO2 max (an easy aerobic intensity) five days a week The levels of oxidative enzymes in the mitochondria in subjects who performed the HIIT program were significantly higher—even though they were training at a fraction of the volume of the aerobic group. How could this favorable endurance adaptation happen with such short periods of exercise? It turns out that the increased mitochondrial density and oxidative-enzyme activity from HIIT are caused by completely different message-signaling pathways than those created by traditional endurance training.

In our own bodies, only the liver is capable of limited regeneration, but chop a limb off a starfish or a salamander, and it will grow a new one. We are starting to understand the molecular signals that are used by these species to regenerate limbs in adult life. Mammals seem to only use this signalling pathway during the growth of the early embryo but it is a pathway that may well have the potential to be reactivated. Following surgical removal, the wings can grow back in embryonic chickens when the production of a protein called wnt is switched on. Frog limb regeneration can also take place later in the life cycle when wnt protein is expressed. Tadpoles have this ability but it is normally lost when they metamorphose into frogs. The expression of wnt signalling protein around an injury is thought to cause a reprogramming or transdifferentiation of mature cells into stem cells capable of producing the cell types needed for the limb. Very young children have been known to re-grow severed fingertips, and so there are intriguing possibilities for human tissue regeneration.

This is central to understanding the nature of motivation, as well as its failures (e.g., during depression, where there is inhibition of dopamine signaling thanks to stress, or in anxiety, where such inhibition is caused by projections from the amygdala).100 It also tells us about the source of the frontocortical power behind willpower. In a task where one chooses between an immediate and a (larger) delayed reward, contemplating the immediate reward activates limbic targets of dopamine (i.e., the mesolimbic pathway), whereas contemplating the delayed reward activates frontocortical targets (i.e., the mesocortical pathway). The greater the activation of the latter, the more likely there’ll be gratification postponement. These studies involved scenarios of a short burst of work soon followed by reward.101 What about when the work required is prolonged, and reward is substantially delayed? In that scenario there is a secondary rise of dopamine, a gradual increase that fuels the sustained work; the extent of the dopamine ramp-up is a function of the length of the delay and the anticipated size of the reward:

It was when they determined that I had been born dead That my life became easier to understand. For a long time, I wondered why rooms felt colder when I entered them, Why nothing I said seemed to stick in anyone’s ear, Frankly, why I never had any money. I wondered Why the cities I walked through drifted into cloud Even as I admired their architecture, as I pointed out The cornerstones marked “1820,” “1950.” The only songs I ever loved were filled with scratch, dispatches from A time when dead ones like me were a dime a dozen. I spent my life in hotels: some looked like mansions, Some more like trailer parks, or pathways toward A future I tried to point to, but how could I point, With nothing but a hand no hand ever matched, With fingers that melted into words that no one read. I rehearsed names that others taught me: Caravaggio, Robert Brandom, Judith, Amber, Emmanuelle Cat. I got hungry the way only the dead get hungry, The hunger that launches a thousand dirty wars, But I never took part in the wars, because no one lets A dead man into their covert discussions. So I drifted from loft to cellar, ageless like a ghost, And America became my compass, and Europe became The way that dead folks talk, in short, who cares, There’s nothing to say because nobody listens, There’s no radio for the dead and the pillows seem Like sand. Let me explain: when you’re alive, As I understand it, pillows cushion the head, the way A lover might soothe the heart. The way it works for me, In contrast, is everything is sand. Beds are sand, The women I profess to love are sand, the sound of music In the darkest night is sand, and whatever I have to say Is sand. This is not, for example, a political poem, Because the dead have no politics. They might have A hunger, but nothing you’ve ever known Could begin to assuage it.

Life is pretty short yet magnanimous if we know just how to live right. It isn't that easy, it takes a lot of our soul, sometimes too many broken pieces to finally come together in binding a masterpiece that smiles like a solitary star forever gazing around at the music of an eternal cosmos. The most brutal yet beautiful truth about Life is that It is marked, marked with Time where every moment takes us closer to death, it doesn't have to sound or feel bad or scary because death is the most inevitable truth in this mortal world. While the knowledge of death jolts our mind with the uncertainty of Life, clutches us in the emotion of fear to think of pain or the loss of bonds, when we acknowledge that as a part of our souls' journey and take every moment as our precious gift, a blessing to experience this Life with its beautiful garden of emotions blossoming with wonderful smiles that we can paint on others, then we make our Life magnanimous, then we make even the very face of death as that of an angel coming to take us to a different voyage, soaked in a lot of memories and experiences beautifully binding our soul. I have realised that when we live each day as if it's the last day of our life, we become more loving and gentle to everyone around and especially to our own selves. We forgive and love more openly, we grace and embrace every opportunity we get to be kind, to stay in touch with everything that truly matters. I have realised that when we rise every morning with gratitude knowing that the breath of air still passes through our body, just in the mere understanding that we have one more day to experience Life once again, we stay more compassionate towards everything and everyone around and invest more of our selves into everything and everyone that truly connect and resonate with our soul. I have realised that when we consciously try to be good and kind, no matter however bad or suffocating a situation is we always end up taking everything at its best holding on to the firm grip of goodness, accepting everything as a part of our souls' lesson or just a turn of Time or Fate and that shapes into our strength and roots our core with the truest understanding of Life, the simple act of going on and letting go. Letting go of anything and everything that chains our Soul while going on with a Heart open to Love and a Soul ready to absorb all that falls along the pathway of this adventure called Life. I have realised that when we are kind and do anything good for another person, that gives us the most special happiness, something so pure that even our hearts don't know how deep that joy permeates inside our soul. I have realised that at the end of the day we do good not because of others but because of our own selves, for if tomorrow death comes to grace me I hope to smile and say I have Lived, loved unconditionally and embraced forgiveness, kindness and goodness and all the other colours of Love with every breath I caught, I have lived a Life magnanimous. So each time someone's unkind towards you, hold back and smile, and try to give your warmth to that person. Because Kindness is not a declaration of who deserves it, it's a statement of who you are. So each time some pieces of your heart lay scattered, hold them up and embrace everyone of them with Love. Because Love is not a magic potion that is spilled from a hollow space, it's a breath of eternity that flows through the tunnel of your soul. So each time Life puts up a question of your Happiness, answer back with a Smile of Peace. Because Happiness is not what you look for in others, it's what you create in every passing moment, with the power of Life, that is pretty short when we see how counted it stands in days but actually turns out absolutely incredibly magnanimous when loved and lived in moments.

With the relief of knowing I had passed through a crisis, I sighed because there was nothing to hold me back. It was no time for fear or pretense, because it could never be this way with anyone else. All the barriers were gone. I had unwound the string she had given me, and found my way out of the labyrinth to where she was waiting. I loved her with more than my body. I don’t pretend to understand the mystery of love, but this time it was more than sex, more than using a woman’s body. It was being lifted off the earth, outside fear and torment, being part of something greater than myself. I was lifted out of the dark cell of my own mind, to become part of someone else—just as I had experienced it that day on the couch in therapy. It was the first step outward to the universe—beyond the universe—because in it and with it we merged to recreate and perpetuate the human spirit. Expanding and bursting outward, and contracting and forming inward, it was the rhythm of being—of breathing, of heartbeat, of day and night—and the rhythm of our bodies set off an echo in my mind. It was the way it had been back there in that strange vision. The gray murk lifted from my mind, and through it the light pierced into my brain (how strange that light should blind!), and my body was absorbed back into a great sea of space, washed under in a strange baptism. My body shuddered with giving, and her body shuddered its acceptance. This was the way we loved, until the night became a silent day. And as I lay there with her I could see how important physical love was, how necessary it was for us to be in each other’s arms, giving and taking. The universe was exploding, each particle away from the next, hurtling us into dark and lonely space, eternally tearing us away from each other—child out of the womb, friend away from friend, moving from each other, each through his own pathway toward the goal-box of solitary death. But this was the counterweight, the act of binding and holding. As when men to keep from being swept overboard in the storm clutch at each other’s hands to resist being torn apart, so our bodies fused a link in the human chain that kept us from being swept into nothing. And in the moment before I fell off into sleep, I remembered the way it had been between Fay and myself, and I smiled. No wonder that had been easy. It had been only physical. This with Alice was a mystery. I leaned over and kissed her eyes. Alice knows everything about me now, and accepts the fact that we can be together for only a short while. She has agreed to go away when I tell her to go. It’s painful to think about that, but what we have, I suspect, is more than most people find in a lifetime.

In short, these professionals need to understand money’s language and be able to speak it to help breakaway students find pathways to higher education and solutions for their financial and family obligations.

The pathways with axons pointed towards the core, and which carry impulses inward, are called the afferent pathways. They originate in the various sensory endings of the body—the exteroceptors on the surface, the proprioceptors in the connective tissues (especially the joints), and the interoceptors in the the internal organs. Their final axons terminate in the sensory cortex. They are often referred to as the sensory pathways. Their job is to carry to all the levels of the nervous system information about everything that is affecting the organism—that is, all sensory stimulation. Four of these afferent pathways are short and distinct, arising from the highly localized and specialized areas of the “special senses”—sight, hearing, taste, and smell. The fifth kind of sensory information, that wide array of sensations we refer to collectively as “touch,” converges on the cortex from virtually every surface and cranny of the body. These are the “somatic senses,” and they include all of the pathways and endings which inform us of our internal state of affairs and our relationship to the outside world. The afferent, inflowing pathways of the nervous system constitute one of the principal tools of bodywork. It is by their means that surface contact and pressure enter into the deeper strata of the mind, where genetic potential and sensory experience are fused into behavior and character. Each successive afferent neuron is a finger reaching deeper and deeper into the interior, making its influence felt on all levels which influence behavior. It is sensory input which has conditioned our reflexes, postures, and habits into the patterns in which we find ourselves living. Nothing would seem to be more reasonable than the expectation that different sensory input can recondition these habits and patterns, alter them, improve them. This input can be different both in the sense of being more, giving additional nutritive contact to the various subtle degrees of “deprivation dwarfism,” and in the sense of being more pleasurable, more caring, softening and dissolving compulsive patterns that have been created by pain and stress.

Those that form the nucleus of our friendships and family bonds, at any given point in our lives, do not necessarily remain with us through time. There may be a variety of reasons for this. The relationships themselves may be fragile or their world may only ever have been intended to collide with ours for a short span of time. Ambition and love draw people in different directions, work lives can create nomadic pathways and loves journeys can take us on geographically diverse paths. Death may also arrive to cause its ultimate diversion or, as so often is the case these days, our mental health may become mental illness.

I can bring a glass of water smoothly to my lips because practice has taught me just how much contractile effort and speed is necessary to lift it and carry it through the air without either dropping it or throwing the water towards the ceiling. This familiar feel for the resistance of the glass of water, and for the appropriate muscular effort to both overcome that resistance and remain in constant control, are functions of the variable settings of the inhibitory response of the Golgi tendon organs. And I use this reflex mechanism every time I use a screwdriver or a wrench, row a boat, push a car, do a push-up or a deep knee bend, pick up an object—in short, every time I need a specific amount of effort delivered in order to accomplish a specific task—any time “too much” is just as mistaken as “too little.” This includes, of course, almost all the controlled uses to which I put my muscles. Now in order to be helpful in all situations, this variable setting of the tension values which trigger the reflex must be capable of both a wide range of adjustment and rapid shifts. Objects that we need to manipulate with carefully controlled efforts may be small or large, light or heavy. Building a rock wall can require just as much finesse and balance as building a house of playing cards, but the levels of tension which require equally sensitive monitoring are very different in each case. Since these relative tension values can be altered rapidly at will, and are refined with practice, it seems evident that they can be controlled by higher brain centers. This is presumably done through descending neural pathways which can generate impulses that either facilitate or inhibit the action of the Golgi/motor neuron synapses. In this way, control signals from higher nervous centers could automatically set the level of tension at which the muscle would be maintained. If the required tension is high, then the muscle tension would be set by the servo-feedback mechanism to this high level of tension. On the other hand, if the desired tension level is low, the muscle tension would be set this level.9

if you need some time away from the crowds, take a short stroll and enjoy the solitude along the walkway between Tomorrowland (to the left of Space Mountain's gift shop) and Mickey's Toontown Fair (to the right of the train station). Most guests never find this pathway, so it remains quiet all day.

warlords battled constantly for supremacy and the possibility of attack was ever present. The castle itself was squat and powerful, with thick walls and heavy towers at each of the four corners. It had none of the soaring grace of Redmont or Castle Araluen. Rather, it was a dark, brooding and forbidding structure, built for war and for no other reason. Halt had told Horace that the word Montsombre translated to mean “dark mountain.” It seemed an appropriate name for the thick-walled building at the end of the winding, tortuous pathway. The name became even more meaningful as they climbed higher. There were poles lining the side of the road, with strange, square structures hanging from them. As they drew closer, Horace could make out, to his horror, that the structures were iron cages, only an arm span wide, containing the remains of what used to be men. They hung high above the roadway, swaying gently in the wind that keened around the upper reaches of the path. Some had obviously been there for many months. The figures inside were dried-out husks, blackened and shriveled by their long exposure, and festooned in fluttering rags of rotting cloth. But others were newer and the men inside were recognizable. The cages were constructed from iron bars arranged in squares, leaving room for ravens and crows to enter and tear at the men’s flesh. The eyes of most of the bodies had been plucked out by the birds. He glanced, sickened, at Halt’s grim face. Deparnieux saw the movement and smiled at him, delighted with the impression his roadside horrors were having on the boy. “Just the occasional criminal,” he said easily. “They’ve all been tried and convicted, of course. I insist on a strict rule of law in Montsombre.” “What were their crimes?” the boy asked. His throat was thick and constricted and it was difficult to form the words. Again, Deparnieux gave him that unconcerned smile. He made a pretense of trying to think. “Let’s say ‘various,’” he replied. “In short, they displeased me.” Horace held the other man’s amused gaze for a few seconds, then,

He wanted to step away from the overtrodden pathways of thought that, painful as they were, had been too easy to follow again and again. It was, in short, a longing to begin anew.

Bliss is an illuminating experience followed by a great feeling of acceptance and calmness. Joy and gratitude are part of this experience. We hold at the same time the deepest sorrow of the world and most exalted happiness. We experience the double nature of reality. ... One of the quickest pathways to bliss is to experience a life threatening illness. All of a sudden life's sweetness and tragedy unfurl before us. When we hear that we may only have a short time to live, life seems incredibly precious.

Although a few enzymes (e.g. carbonic anhydrase) catalyse a single isolated reaction, most are part of a team that catalyses a series of reactions in which each enzyme picks up its predecessor’s product, taking it a step further to create a metabolic pathway. This pathway may be to build up, say, an amino acid from simpler starting molecules, or conversely to break down food molecules to yield new chemical building blocks and sometimes also to trap useable energy. Life is the combined outcome of this seemingly logical enzyme teamwork. Like most things in the living world, this gives the appearance of purposeful planning down to the last detail. Such meticulous perfection would in past eras have been confidently attributed to the attentive skill of an all-powerful Creator. Since Charles Darwin, however, we have an alternative way of explaining how things in the living world come to be the way they are. Darwin led us to understand that natural selection could bring about stepwise beneficial adaptation over thousands or even millions of years, and, in the 150 years since the Origin of Species, we have learnt far more about the genetic mechanisms that can bring about such change. Does this kind of thinking work at the molecular level when we come to look at metabolic pathways and individual enzymes? In fact the study of enzymes and other proteins allows us to be a great deal more certain than Victorian biologists could be. Many of the distinctive biological characteristics studied in comparing animals and plants, like eye colour or wing shape, have turned out to be controlled by multiple genes, whereas, in looking at individual proteins, we are looking at the products of individual genes, and latterly we can even examine those genes directly. The possibility of determining protein amino acid sequences, and, more recently, the corresponding DNA sequences, allows comparison of the same enzyme from many species and also of enzymes catalysing different but similar reactions from a single species.

The Japanese word zen in fact means "meditation" or "state of meditative concentration." In Chinese, zen is pronounced chan. Chan is short for channa, which is how the CHinese pronounced dhyana, the Sanskrit word used in India for practices or rarified states of meditative concentration.

I recommend that you begin with short ten-minute meditation periods, once or twice a day, and over several weeks gradually lengthen your meditation periods to twenty-five minutes, even if you can only find time to do this once a day. Even for an experienced meditator, it often takes ten or fifteen minutes to really settle into a meditative state, and so it is not surprising that the minimum length of time for a meditation period in temples and monasteries is usually twenty-five minutes.

She stepped inside and followed a brick pathway lined with short trees bearing clusters of disproportionately large, bell-shaped blooms. They gave off a cloying scent like a bottle of dropped perfume. Her backpack brushed one of the trees as she passed, and suddenly a swirl of tiny turquoise birds flew out.

you can start to formulate your get-away plan. Via the thalamic pathways, the body and brain become primed for action. Now, what’s needed is some cognitive input — a little thought, to refine your escape. The second pathway, after a short stopover at the cortex, continues back to the amygdala, where it meets up with the original thalamic pathway.

Withdrawal occurs once a person stops eating any addictive food. Though abstaining from foods is a contentious subject in the scientific literature, there is no question that it will cause a level of discomfort that often drives addicts back to eating... Feelings of deprivation, obsessions about food, and anxiety arising from unresolved trauma that was being 'medicated' by the addictive foods may appear like spectres that linger, worsening before they get better... It may seem that life without one's comfort foods is simply not worth living. Even problematic eating is seen as better than feeling bereft to the point of suicidal thoughts. But others might find the symptoms so common they are not even recognizable as withdrawal... The good news is that detoxification is not a long process; it only lasts for a relatively short period - between one week and four weeks... Cheating by having a bite here or a spoonful there is also an excellent way to suffer withdrawal in perpetuity. Withdrawal will not end if the substance is constantly being reintroduced back into the brain reward pathway.

Modern economics, by which I mean the style of economics taught and practised in today's leading universities, likes to start the enquiries from the ground up: from individuals, through the household, village, district, state, country, to the whole world. In various degrees, the millions of individual decisions shape the eventualities people face; as both theory, common sense, and evidence tell us that there are enormous numbers of consequences of what we all do. Some of these consequences have been intended, but many are unintended. There is, however, a feedback, in that those consequences in turn go to shape what people subsequently can do and choose to do. When Becky's family drive their cars or use electricity, or when Desta's family create compost or burn wood for cooking, they add to global carbon emissions. Their contributions are no doubt negligible, but the millions of such tiny contributions sum to a sizeable amount, having consequences that people everywhere are likely to experience in different ways. It can be that the feedbacks are positive, so that the whole contribution is greater than the sum of the parts. Strikingly, unintended consequences can include emergent features, such as market prices, at which the demand for goods more or less equals their supply. Earlier, I gave a description of Becky's and Desta's lives. Understanding their lives involves a lot more; it requires analysis, which usually calls for further description. To conduct an analysis, we need first of all to identify the material prospects the girls' households face - now and in the future, under uncertain contingencies. Second, we need to uncover the character of their choices and the pathways by which the choices made by millions of households like Becky's and Desta's go to produce the prospects they all face. Third, and relatedly, we need to uncover the pathways by which the families came to inherit their current circumstances. These amount to a tall, even forbidding, order. Moreover, there is a thought that can haunt us: since everything probably affects everything else, how can we ever make sense of the social world? If we are weighed down by that worry, though, we won't ever make progress. Every discipline that I am familiar with draws caricatures of the world in order to make sense of it. The modern economist does this by building models, which are deliberately stripped down representations of the phenomena out there. When I say 'stripped down', I really mean stripped down. It isn't uncommon among us economists to focus on one or two causal factors, exclude everything else, hoping that this will enable us to understand how just those aspects of reality work and interact. The economist John Maynard Keynes described our subject thus: 'Economics is a science of thinking in terms of models joined to the art of choosing models which are relevant to the contemporary world.

Then there are the fully intentional pleasures, which, although in some way tied up with sensory or perceptual experience, are modes of exploration of the world. Aesthetic pleasures are like this. Aesthetic pleasures are contemplative - they involve studying an object OUTSIDE of the self, to which one is GIVING something (namely, attention and all that flows from it), and not TAKING, as in the pleasure that comes from drugs and drinks. Hence such pleasures are not addictive - there is no pathway to reward that can be short-circuited here, and a serotonin injection is not a cheap way of obtaining the experience of PARISFAL or THE MERCHANT OF VENICE.

This hijacking of the brain’s attention by an overload of social stimulation engages the same chemical pathways of reward as do such drugs as caffeine, nicotine, cocaine, and the amphetamines. Drugs with abuse potential short-circuit and amplify the rewarding dopamine responses to normal social interactions by blocking the dopamine-recycling systems that balance dopamine with the other chemical messengers, such as serotonin, and protect the brain from excess stimulation. Cocaine or amphetamines, for example, when taken in small doses induce the rush of an immediate and pleasurable high. But with repeated use or excessive dose, the pleasure dissolves into a dysphoric and dangerous, drug-driven mania. From

FRESH GRIEF FEELS LIKE THIS: Your mind is a maze and every pathway leads to a bricked-up wall, the one where you can see the real world just on the other side, but you can’t reach it. It’s a feeling like someone’s scooped out your insides with a spoon and all that’s left is a shell that walks like you and talks like you, but your body and soul have parted ways for a time. Your senses don’t fire and you can’t connect with another human being because to string all that grief together like a strand of paper dolls would create something as powerful as an atom bomb—you’d implode. So you’re all alone. And, for a short while, at least until it sinks in, you can fake anything.

Something was wrong with the devices themselves. Digging deep into the internal structure of the circuit boards with powerful microscopes, Simon's team had discovered broken and incorrect connections, electronic dead-ends, short circuits, and nonsensical pathways.

This table only counts physical health effects due to disruptions that took place in the Illusion of Control phase. It considers both short-run and long-run effects. Each of the claimed effects is based on a published study about that effect. First on the list is the disruption to vaccination programs for measles, diphtheria, cholera, and polio, which were either cancelled or reduced in scope in some 70 countries. That disruption was caused by travel restrictions. Western experts could not travel, and within many poor countries travel and general activity were also halted in the early days of the Illusion of Control phase. This depressive effect on vaccination programs for the poor is expected to lead to large loss of life in the coming years. The poor countries paying this cost are most countries in Africa, the poorer nations in Asia, such as India, Indonesia and Myanmar, and the poorer countries in Latin America. The second listed effect in the table relates to schooling. An estimated 90% of the world’s children have had their schooling disrupted, often for months, which reduces their lifetime opportunities and social development through numerous direct and indirect pathways. The UN children’s organisation, UNICEF, has released several reports on just how bad the consequences of this will be in the coming decades.116 The third element in Joffe’s table refers to reports of economic and social primitivisation in poor countries. Primitivisation, also seen after the collapse of the Soviet Union in the early 1990s, is just what it sounds like: a regression away from specialisation, trade and economic advancement through markets to more isolated and ‘primitive’ choices, including attempted economic self-sufficiency and higher fertility. Due to diminished labour market prospects, curtailed educational activities and decreased access to reproductive health services, populations in the Illusion of Control phase began reverting to having more children precisely in those countries where there is already huge pressure on resources. The fourth and fifth elements listed in the table reflect the biggest disaster of this period, namely the increase in extreme poverty and expected famines in poor countries. Over the 20 years leading up to 2020, gradual improvements in economic conditions around the world had significantly eased poverty and famines. Now, international organisations are signalling rapid deterioration in both. The Food and Agriculture Organisation (FAO) now expects the world to have approximately an additional 100 million extremely poor people facing starvation as a result of Covid policies. That will translate into civil wars, waves of refugees and huge loss of life. The last two items in Joffe’s table relate to the effect of lower perinatal and infant care and impoverishment. Millions of preventable deaths are now expected due to infections and weakness in new mothers and young infants, and neglect of other health problems like malaria and tuberculosis that affect people in all walks of life. The whole of the poor world has suffered fewer than one million deaths from Covid. The price to be paid in human losses in these countries through hunger and health neglect caused by lockdowns and other restrictions is much, much larger. All in the name of stopping Covid.

At that point, she came upon a technique of relinquishing guilt by studying the “Workbook” of A Course in Miracles. In working with this home-study course, which consists of contemplating exactly one short lesson a day for 365 days, she began to undo all of her guilt and resentment through the mechanism of forgiveness.

As you craft a business story for your company, it is worth reminding yourself that you are not a creative novelist and that you are creating a foundation for a valuation. Consequently, you should aim to do the following: Keep it simple: When telling business stories for companies, it is easy to get distracted by strands of these stories that may be interesting but that have little relevance for value. The most powerful business stories in valuation tend to be compact, boiling the company down to its core. In our valuations of Amazon from 1997 to 2012, our core story for Amazon was that it was a Field of Dreams company, built around the belief that if you build it (revenues), they (profits) will come, and in our valuations after 2013, the story shifted to that of a Disruption Machine, a company that would go after any business that it felt had soft spots that could be exploited by a more efficient and patient player. Keep it focused: No matter what business you are valuing, the end game, for it to be valuable, is that it must make money. In short, a business story, even if it is not money making now, must include pathways to make money in the future.

say never start a story with a waking, but when you’ve been hard asleep for thirty years it’s difficult to know where else to begin. Start with a waking, end with a wake, maybe. Hard asleep is, I am informed, the technical term. Hard, because you’re shut down, dried out, frozen for the trip from star to star. They have it down to a fine art—takes eleven minutes, like clockwork. A whole ship full of miscreants who are desiccated down to something that can… well, I was about to say survive indefinitely, but that’s not how it goes, of course. You don’t survive. You die, but in a very specific flash-frozen way that allows for you to be restarted again more or less where you left off at the other end. After all the shunting about that would kill any body—the permanent, non-recoverable kind of kill—who wasn’t withered down. They pump you full of stuff that reinflates you to more or less your previous dimensions—you’ll note there’s a lot of more or less in this process. It is an exact science, just not one that cares about the exact you. Your thought processes don’t quite pick up where they left off. Short-term memory isn’t preserved; more recent mental pathways don’t make the cut. Start with a waking, therefore, because in that instant it’s all you’ve got, until you can establish some connection to older memories. You know who you are, but you don’t know where you are or how you got there. Which sounds terrifying but then let me tell you what you’re waking up into: actual hell. The roaring of colossal structural damage as the ship breaks up all around you. The jostling jolt as the little translucent bubble of plastic you’re travelling in is jarred loose and begins to tumble. A cacophony of vibration coming through the curved surface to you: the death throes of the vessel which has carried you all this way, out into the void, and is now fragmenting. There’s a world below that you know nothing about, not in your head right then. And above you are only the killing fields of space. The fact there’s a below and an above shows that the planet’s already won that particular battle over your soul and you’re falling.

... if we went out the way we came in, you'd never find anything. It's too short.

We all need to feel safe, that the world is predicable, that obstacles can be overcome, and conflicts resolved -in short, to maintain narcissistic equilibrium. When such conditions are met, infants can pleasurably engage with their environments. When faced with overwhelming experience, internal or external, they must find a way to restore their fragile self-esteem. Some infants, especially when faced with overwhelm that cannot be overcome, turn away from reality and toward omnipotent solution. This learned response feels dependable and, over time, takes on an addictive quality, restricting her access to other solutions and pathways to further growth.

Like the team at the FDA, the EIR team enlisted entrepreneurs familiar with the obstacles, including SoftLayer senior executive Paul Ford, to work alongside the USCIS personnel committed to removing or clearing them. “You get fresh thinking, you get a very low-cost way of trying to impact the situation because the people doing this are committed to try to find what’s not working and propose solutions, rather than take a partisan or political or hierarchical or structural view to the environment,” Feld said. “They’re short-timers, so they’re committed for a period of time to come do something, but they’re not here for career advancement, so they are going to speak their mind.” Feld also believed that the presence of Ford and other outside entrepreneurs made the participants feel more comfortable to speak freely than if they had been working with government officials alone. In the spring of 2012, the team began building a prototype of an alternative application process for entrepreneurs and by fall had achieved a significant breakthrough: the launch of the Entrepreneurship Pathways web portal, designed to close the information gap between USCIS and those in the entrepreneurial community, by letting them know which visa may be most appropriate—including the O-1—for their situation.24 While the results of this exercise were not empirically conclusive at the time of an interview for this book, Feld did offer his anecdotal assessment “that there’s an increased number of people who I know have been able to get into the country and get valid visas who are entrepreneurs. I’ve definitely heard a decrease in the negative.

Agreeable, compassionate, empathic, conflict-averse people (all those traits group together) let people walk on them, and they get bitter. They sacrifice themselves for others, sometimes excessively, and cannot comprehend why that is not reciprocated. Agreeable people are compliant, and this robs them of their independence. The danger associated with this can be amplified by high trait neuroticism. Agreeable people will go along with whoever makes a suggestion, instead of insisting, at least sometimes, on their own way. So, they lose their way, and become indecisive and too easily swayed. If they are, in addition, easily frightened and hurt, they have even less reason to strike out on their own, as doing so exposes them to threat and danger (at least in the short term). That’s the pathway to dependent personality disorder, technically speaking.198 It might be regarded as the polar opposite of antisocial personality disorder, the set of traits characteristic of delinquency in childhood and adolescence and criminality in adulthood. It would be lovely if the opposite of a criminal was a saint—but it’s not the case. The opposite of a criminal is an Oedipal mother, which is its own type of criminal.

This final maturation process of the nerves and brain takes place during the first three months of Baby's life - some experts even say it's the first nine months - also known as "The Fourth Trimester". This short period of time is vital for your baby's physical and emotional development. Imagine the shock of emerging from the most peaceful, luxurious warm bath into a cold world as bright and loud as Times Square on New Year's Eve. You can't comprehend what's happened and you can't communicate to anyone about it. Meanwhile, you are being bombarded with stimuli your brain and body are not yet ready to process. It's enough to give a fully-grown adult a panic attack. Without the proper support in the beginning of life, babies can carry that initial anxiety with them throughout their development, ingraining it into their nervous pathways.

of stimulating reward pathways in the brain, such as drugs, sex, aggression, and intimidating others, could become relatively more attractive and less constrained by concern about violating trusting relationships. The ability to modify behavior based on negative experiences may be impaired.30 Hard-core drug addicts, whose lives invariably began under conditions of severe stress, are all too readily triggered into a stress reaction. Not only does the stress response easily overwhelm the addict’s already-challenged capacity for rational thought when emotionally aroused, but the hormones of stress also “cross-sensitize” with addictive substances. The more one is present, the more the other is craved. Addiction is a deeply ingrained response to stress, an attempt to cope with it through self-soothing. Maladaptive in the long term, it is highly effective in the short term. Predictably, stress is a major cause of continued drug dependence. It increases opiate craving and use, enhances the reward efficacy of drugs, and provokes relapse to drug seeking and drug taking.31 “Exposure to stress is the most powerful and reliable experimental manipulation used to induce reinstatement of alcohol or drug use,” one team of researchers reports.32 “Stressful experiences,” another research group points out, “increase the vulnerability of the individual to either develop drug self-administration or relapse.”33

He argues that short-term memory pathways will start to deteriorate from underuse if we overuse technology.

Agreeable, compassionate, empathic, conflict-averse people (all those traits group together) let people walk on them, and they get bitter. They sacrifice themselves for others, sometimes excessively, and cannot comprehend why that is not reciprocated. Agreeable people are compliant, and this robs them of their independence. The danger associated with this can be amplified by high trait neuroticism. Agreeable people will go along with whoever makes a suggestion, instead of insisting, at least sometimes, on their own way. So, they lose their way, and become indecisive and too easily swayed. If they are, in addition, easily frightened and hurt, they have even less reason to strike out on their own, as doing so exposes them to threat and danger (at least in the short term). That’s the pathway to dependent personality disorder, technically speaking.

The universe you inhabit and the life you have today come from God’s hand as something you do not deserve. Your life is on loan for a short while, and one day God will call time and take it back, just like the library will recall that overdue book on your shelf. So embrace life for what it is rather than what you’d like it to be. Live it before God with reverence and obedience. This is the pathway to joy, even though as you walk it, there will be mystery and pain. Have some nice food. Enjoy a good wine if you want—​​​but be sure to enjoy whatever good things come your way. Chapter 4 adds a new layer to this picture. As you enjoy, share. Share what you have with others. It’s as simple as

long; team ministry is the higher pathway. Are you in this for the long haul or just the short run? To judge a city or build one up?