Short Down Syndrome Quotes

Nell's husband has short-man syndrome. Eddie is one of those deadly dull people who is so upbeat that I suspect he would subconsciously like to go through the neighborhood, house by house, with a machine gun. He seems oblivious to the effect that his long, rambling monologues have on people - he doesn't notice the blank faces, the fingers flexing like those of people buried alive, the ocular tics. You could write down his words verbatim, show them to him, and he'd probably say, 'I know someone just like that!' Then he'd tell you about that person until your teeth hurt. His hostage-taking is passive-aggressive.

Ionizing radiation takes three principal forms: alpha particles, beta particles, and gamma rays. Alpha particles are relatively large, heavy, and slow moving and cannot penetrate the skin; even a sheet of paper could block their path. But if they do manage to find their way inside the body by other means—if swallowed or inhaled—alpha particles can cause massive chromosomal damage and death. Radon 222, which gathers as a gas in unventilated basements, releases alpha particles into the lungs, where it causes cancer. Polonium 210, a powerful alpha emitter, is one of the carcinogens in cigarette smoke. It was also the poison slipped into the cup of tea that killed former FSB agent Alexander Litvinenko in London in 2006. Beta particles are smaller and faster moving than alpha particles and can penetrate more deeply into living tissue, causing visible burns on the skin and lasting genetic damage. A piece of paper won’t provide protection from beta particles, but aluminum foil—or separation by sufficient distance—will. Beyond a range of ten feet, beta particles can cause little damage, but they prove dangerous if ingested in any way. Mistaken by the body for essential elements, beta-emitting radioisotopes can become fatally concentrated in specific organs: strontium 90, a member of the same chemical family as calcium, is retained in the bones; ruthenium is absorbed by the intestine; iodine 131 lodges particularly in the thyroid of children, where it can cause cancer. Gamma rays—high-frequency electromagnetic waves traveling at the speed of light—are the most energetic of all. They can traverse large distances, penetrate anything short of thick pieces of concrete or lead, and destroy electronics. Gamma rays pass straight through a human being without slowing down, smashing through cells like a fusillade of microscopic bullets. Severe exposure to all ionizing radiation results in acute radiation syndrome (ARS), in which the fabric of the human body is unpicked, rearranged, and destroyed at the most minute levels. Symptoms include nausea, vomiting, hemorrhaging, and hair loss, followed by a collapse of the immune system, exhaustion of bone marrow, disintegration of internal organs, and, finally, death.

Until recently, three unspoken principles have guided the arena of genetic diagnosis and intervention. First, diagnostic tests have largely been restricted to gene variants that are singularly powerful determinants of illness—i.e., highly penetrant mutations, where the likelihood of developing the disease is close to 100 percent (Down syndrome, cystic fibrosis, Tay-Sachs disease). Second, the diseases caused by these mutations have generally involved extraordinary suffering or fundamental incompatibilities with “normal” life. Third, justifiable interventions—the decision to abort a child with Down syndrome, say, or intervene surgically on a woman with a BRCA1 mutation—have been defined through social and medical consensus, and all interventions have been governed by complete freedom of choice. The three sides of the triangle can be envisioned as moral lines that most cultures have been unwilling to transgress. The abortion of an embryo carrying a gene with, say, only a ten percent chance of developing cancer in the future violates the injunction against intervening on low-penetrance mutations. Similarly, a state-mandated medical procedure on a genetically ill person without the subject’s consent (or parental consent in the case of a fetus) crosses the boundaries of freedom and noncoercion. Yet it can hardly escape our attention that these parameters are inherently susceptible to the logic of self-reinforcement. We determine the definition of “extraordinary suffering.” We demarcate the boundaries of “normalcy” versus “abnormalcy.” We make the medical choices to intervene. We determine the nature of “justifiable interventions.” Humans endowed with certain genomes are responsible for defining the criteria to define, intervene on, or even eliminate other humans endowed with other genomes. “Choice,” in short, seems like an illusion devised by genes to propagate the selection of similar genes.

Ode to Charlie THE DOG OF A LIFETIME We got a pup named Charlie One year at Christmastime. He changed our lives completely So I’ll share this dog rhyme. His ears were long and dangly, His legs were short and fat, His naps were almost constant, ’Cept when he chased the cat. I dressed him up in outfits, In dresses, shirts, and jeans, In boots and leather loafers-- The dapp’rest pup I’d seen! He started working cattle With Ladd and all the crew. He thought this was his purpose. Oh, if he only knew! That he was just a Bassett And bred for not so much. But Charlie rose above it And learned that cowdog touch. But man, that short dog syndrome… He thought he was in charge And ruled the other doggies His bravado, always large! But deep down, all he wanted Were tummy rubs all day And sausage, ham, and burgers And bacon, I would say. He snored just like an engine, His breath was not so great, His ears were always crusty From hanging in his plate. But Charlie Boy was perfect And loyal through and through. He knew what we were thinking, He sensed what we would do. We thought he’d live forever But cancer came and stayed, Then left with our dear Charles And left us all dismayed. And yet, we feel so lucky He got to be our friend. We have a million memories Right up until the end. We loved you, Charlie, you were the best We never will forget you And the very second we get to Heaven… We’re coming straight to get you!

British colonial disdain for human rights even left its mark on the English language. The word “coolie” was borrowed from a Chinese word that literally means “bitter labor.” The Romanized first syllable coo means “bitter” and the second syllable lie mimics the pronunciation of the Chinese logograph that means “labor.” This Chinese word sprang into existence shortly after the Opium War in the nineteenth century when Britain annexed several territories along the eastern seaboard of China. Those territories included Hong Kong, parts of Shanghai, Canton city (Guangzhou) and parts of Tianjin, a seaport near Beijing. In those newly acquired territories, the British employed a vast number of manual laborers who served as beasts of burden on the waterfront in factories and at train stations. The coolies’ compensation was opium, not money. The British agency and officers that conceived this unusual scheme of compensation—opium for back-breaking hard labor—were as pernicious and ruthless as they were clever and calculating. Opium is a palliative drug. An addict becomes docile and inured to pain. He has no appetite and only craves the next fix. In the British colonies and concessions, the colonizers, by paying opium to the laborers for their long hours of inhumane, harsh labor, created a situation in which the Chinese laborers toiled obediently and never complained about the excessive workload or the physical devastation. Most important of all, the practice cost the employers next to nothing to feed and house the laborers, since opium suppressed the appetite of the addicts and made them oblivious to pain and discomfort. What could be better or more expedient for the British colonialists whose goal was to make a quick fortune? They had invented the most efficient and effective way to accumulate capital at a negligible cost in a colony. The only consequence was the loss of lives among the colonial subjects—an irrelevant issue to the colonialists. In addition to the advantages of this colonial practice, the British paid a pittance for the opium. In those days, opium was mostly produced in another British colony, Burma, not far from China. The exploitation of farmhands in one colony lubricated the wheels of commerce in another colony. On average, a coolie survived only a few months of the grim regime of harsh labor and opium addiction. Towards the end, as his body began to break down from malnutrition and overexertion, he was prone to cardiac arrest and sudden death. If, before his death, a coolie stumbled and hurt his back or broke a limb, he became unemployed. The employer simply recruited a replacement. The death of coolies in Canton, Hong Kong, Shanghai and other coastal cities where the British had established their extraterritorial jurisdiction during the late 19th century was so common that the Chinese accepted the phenomenon as a routine matter of semi-colonial life. Neither injury nor death of a coolie triggered any compensation to his family. The impoverished Chinese accepted injury and sudden death as part of the occupational hazard of a coolie, the “bitter labor.” “Bitter” because the labor and the opium sucked the life out of a laborer in a short span of time. Once, a 19th-century British colonial officer, commenting on the sudden death syndrome among the coolies, remarked casually in his Queen’s English, “Yes, it is unfortunate, but the coolies are Chinese, and by God, there are so many of them.” Today, the word “coolie” remains in the English language, designating an over-exploited or abused unskilled laborer.

Tourette’s syndrome is a neurodevelopmental disorder where the patient frequently suffers from involuntary convulsive movements (tics) which in some cases are associated with involuntary swearing. Two unrelated individuals with this disorder were shown to have the same single base change in the 3′ UTR of a gene called SLITRK139. SLITRK1 appears to be required for neuronal development. The base change in the Tourette’s patients introduced a binding site for a short ncRNA called miR-189. This suggests that SLITRK1 expression may be abnormally down-regulated via such binding, at critical points in development. This alteration is only present in a few cases of Tourette’s but raises the tantalising suggestion that mis-regulation of miRNA binding sites in other neuronal genes may be involved in other patients.

Then she told me I should probably invest in an athletic cup because she was pretty sure she was going to come down with Restless Leg Syndrome and start kicking people willy-nilly whenever the mood struck,” Brian continued. “She’s crazy.

She traced the dragon’s body on his biceps where it transitioned into rope. “I just thought it would be more difficult. After all this time, the heartache, the waiting, the despairing and giving up, the pure pissed-offness of dealing with near misses…" She blew out a breath. “And there it is. With you, easy as breathing. ‘I’m in love with you.’ You said it and meant it. It changes the universe, but the way throwing a stone in a pond does. All those ripples. It's…amazing.” She frowned and cocked her head. “There should at least be dramatic music.” "I can retract it if you want. Brood for a while, play commitment paranoia games, alienate you so we break up, sort of, and then I chase you down before you make some monumental decision, like moving back to New York, or signing up for a three year stint in the merchant marines. Then we can have a big makeup scene.“ She pursed her lips. "Complete with dramatic music.” "Absolutely. If I could afford it, I’d hire John Williams to come up with the score.“ "You’d do all that for me?” "Hell, no.” He snorted, puffing a short, playful breath against her. “I’d tie you up and keep you in my basement until you contracted Stockholm syndrome and couldn’t breathe without me.“ She tipped her head back, sobering. "Sometimes, it feels like I can’t. Crazy, right?” He put his mouth on hers and took her air in the best kind of way, all while giving it back to her. at her, boyishly appealing, but then sobered. "We’re normal, extraordinary people,” he said. “It took us a while, but we always knew what it would look like when it happened. The simplicity of it is what makes it extraordinary. A tadpole gets legs and walks on land, and evolution begins. All in a simple blink, the whole world changes.

My favourite quotes, Part Two -- from Michael Connelly's "Harry Bosch" series The Black Box On Bosch’s first call to Henrik, the twin brother of Anneke - Henrik: "I am happy to talk now. Please, go ahead.” “Thank you. I, uh, first want to say as I said in my email that the investigation of your sister’s death is high priority. I am actively working on it. Though it was twenty years ago, I’m sure your sister’s death is something that hurts till this day. I’m sorry for your loss.” “Thank you, Detective. She was very beautiful and very excited about things. I miss her very much.” “I’m sure you do.” Over the years, Bosch had talked to many people who had lost loved ones to violence. There were too many to count but it never got any easier and his empathy never withered. The Burning Room 2 Grace was a young saxophonist with a powerful sound. She also sang. The song was “Somewhere Over the Rainbow,” and she produced a sound from the horn that no human voice could ever touch. It was plaintive and sad but it came with an undeniable wave of underlying hope. It made Bosch think that there was still a chance for him, that he could still find whatever it was he was looking for, no matter how short his time was. ---------------- He grabbed his briefcase off his chair and walked toward the exit door. Before he got there, he heard someone clapping behind him. He turned back and saw it was Soto, standing by her desk. Soon Tim Marcia rose up from his cubicle and started to clap. Then Mitzi Roberts did the same and then the other detectives. Bosch put his back against the door, ready to push through. He nodded his thanks and held his fist up at chest level and shook it. He then went through the door and was gone. The Burning Room 3 “What do you want to know, Bosch?” Harry nodded. His instinct was right. The good ones all had that hollow space inside. The empty place where the fire always burns. For something. Call it justice. Call it the need to know. Call it the need to believe that those who are evil will not remain hidden in darkness forever. At the end of the day Rodriguez was a good cop and he wanted what Bosch wanted. He could not remain angry and mute if it might cost Orlando Merced his due. ------------ “I have waited twenty years for this phone call . . . and all this time I thought it would go away. I knew I would always be sad for my sister. But I thought the other would go away.” “What is the other, Henrik?” Though he knew the answer. “Anger . . . I am still angry, Detective Bosch.” Bosch nodded. He looked down at his desk, at the photos of all the victims under the glass top. Cases and faces. His eyes moved from the photo of Anneke Jespersen to some of the others. The ones he had not yet spoken for. “So am I, Henrik,” he said. “So am I.” Angle of Investigation 1972 They were heading south on Vermont through territory unfamiliar to him. It was only his second day with Eckersly and his second on the job. Now He knew that passion was a key element in any investigation. Passion was the fuel that kept his fire burning. So he purposely sought the personal connection or, short of that, the personal outrage in every case. It kept him locked in and focused. But it wasn’t the Laura syndrome. It wasn’t the same as falling in love with a dead woman. By no means was Bosch in love with June Wilkins. He was in love with the idea of reaching back across time and catching the man who had killed her. The Scarecrow At one time the newsroom was the best place in the world to work. A bustling place of camaraderie, competition, gossip, cynical wit and humor, it was at the crossroads of ideas and debate. It produced stories and pages that were vibrant and intelligent, that set the agenda for what was discussed and considered important in a city as diverse and exciting as Los Angeles.

Nigga, you need to calm yo lil’ short syndrome looking ass down somewhere. Like where the fuck did you leave your height at the muthafuckin’ crib, nigga? Coming up in here talking shit and yo’ ass got the nerve to be the size of my muthafuckin’ shoe,” Nas said to him, as he and Priest both burst out laughing.

18 Jail-Time He was in Gentry's loft. He was watching Cherry do nurse-things to Gentry. Cherry looked over at him from where she sat on the edge of Gentry's bed. 'How y'doin', Slick?' 'Okay... I'm okay.' 'Remember me asking you before?' He was looking down at the face of the man Kid Afrika called the Count. Cherry was fiddling with something on the stretcher's superstructure, a bag of fluid the color of oatmeal. 'How y'feel, Slick?' 'Feel okay.' 'You're not okay. You keep for-' He was sitting on the floor of Gentry's loft. His face was wet. Cherry was kneeling beside him, close, her hands on his shoulders. 'You did time?' He nodded. 'Chemo-penal unit?' 'Yeah.' 'Induced Korsakov's?' He - 'Episodes?' Cherry asked him. He was sitting on the floor in Gentry's loft. Where was Gentry? 'You get episodes like this? Short term-memory goes?' How did she know? Where was Gentry? 'What's the trigger?' 'What triggers the syndrome, Slick? What kicks you into jail-time?' He was sitting on the floor in Gentry's loft and Cherry was practically on top of him. 'Stress,' he said, wondering how she knew about that. 'Where's Gentry?' 'I put him to bed.' 'Why?' 'He collapsed. When he saw that thing...' 'What thing?' Cherry was pressing a pink derm against his wrist. 'Heavy trank,' she said. 'Maybe get you out of it...' 'Out of what?' She sighed. 'Never mind.

You could always change your name to Barbie," Della said, grinning. "My mom wouldn't even let us play with Barbie because she said it was an unhealthy body image. I think it was because she knew that with us being part Asian, we would probably suffer from the no butt, no boobs syndrome. And she didn't want us to get our body image from a stacked piece of plastic." "You've got a butt," Miranda said. "Yeah, thank God. I at least got that from my mom. She's not short on bootie." She looked down at her chest. "Unfortunately, I took my dad's boobs.