Short Antibiotics Quotes

Because we humans are big and clever enough to produce and utilize antibiotics and disinfectants, it is easy to convince ourselves that we have banished bacteria to the fringes of existence. Don't you believe it. Bacteria may not build cities or have interesting social lives, but they will be here when the Sun explodes. This is their planet, and we are on it only because they allow us to be.

As James Surowiecki noted in a New Yorker article, given a choice between developing antibiotics that people will take every day for two weeks and antidepressants that people will take every day for ever, drug companies not surprisingly opt for the latter. Although a few antibiotics have been toughened up a bit, the pharmaceutical industry hasn’t given us an entirely new antibiotic since the 1970s.

pharmaceutical industry hasn’t given us an entirely new antibiotic since the 1970s. Our

That’s my problem with new-age stuff. In common with many irrational views it harks back to a sense of something ancient while rejecting anything provably historical. It’s like the miserable concept of Original Sin. There seems to be an obsession with the idea that there were ancient humans, uncorrupted by their capricious intellects, who lived in the ‘right way’. They didn’t eat too much dairy or any wheat. They didn’t sit down too long for their spines or walk around in posture-ruining shoes. They didn’t consume too many sugars or fats for their unblemished guts to digest, or pop painkilling and antibiotic tablets to deal with the short-term symptoms of long-term problems that should be dealt with by wholesale lifestyle change. They didn’t drink or smoke. They were perfect and we should sling out all our stuff and emulate them. Except they had an average life expectancy of about 18 and the planet could only support a few hundred thousand of them. Apart from that, good plan.

They maintain their own DNA. They reproduce at a different time from their host cell. They look like bacteria, divide like bacteria, and sometimes respond to antibiotics in the way bacteria do.

If you wanna plan for the long-run, stock up on paper, antibiotics, entertainment items, how-to books, and soap.  If you’re more interested in short-term gains, I’d say stick with knives, seeds, drugs, booze, coffee, and cigarettes. 

About once every million divisions, they produce a mutant. Usually this is bad luck for the mutant—change is always risky for an organism—but just occasionally the new bacterium is endowed with some accidental advantage, such as the ability to elude or shrug off an attack of antibiotics. With this ability to evolve rapidly goes another, even scarier advantage.

The speedy evolution of antibiotic resistance is not surprising, because bacteria multiply fast and are present in enormous numbers, so that any mutation that can make a cell resistant is sure to occur in a few bacteria in a population; if the bacteria are able to survive the change to their cell functions caused by the mutation and to multiply, a resistant population can rapidly build up.

We couldn’t live for two minutes without them, yet even after a billion years mitochondria behave as if they think things might not work out between us. They maintain their own DNA. They reproduce at a different time from their host cell. They look like bacteria, divide like bacteria, and sometimes respond to antibiotics in the way bacteria do. In short, they keep their bags packed. They don’t even speak the same genetic language as the cell in which they live. It is like having a stranger in your house, but one who has been there for a billion years.

The final misconception is that evolution is “just a theory.” I will boldly assume that readers who have gotten this far believe in evolution. Opponents inevitably bring up that irritating canard that evolution is unproven, because (following an unuseful convention in the field) it is a “theory” (like, say, germ theory). Evidence for the reality of evolution includes: Numerous examples where changing selective pressures have changed gene frequencies in populations within generations (e.g., bacteria evolving antibiotic resistance). Moreover, there are also examples (mostly insects, given their short generation times) of a species in the process of splitting into two. Voluminous fossil evidence of intermediate forms in numerous taxonomic lineages. Molecular evidence. We share ~98 percent of our genes with the other apes, ~96 percent with monkeys, ~75 percent with dogs, ~20 percent with fruit flies. This indicates that our last common ancestor with other apes lived more recently than our last common ancestor with monkeys, and so on. Geographic evidence. To use Richard Dawkins’s suggestion for dealing with a fundamentalist insisting that all species emerged in their current forms from Noah’s ark—how come all thirty-seven species of lemurs that made landfall on Mt. Ararat in the Armenian highlands hiked over to Madagascar, none dying and leaving fossils in transit? Unintelligent design—oddities explained only by evolution. Why do whales and dolphins have vestigial leg bones? Because they descend from a four-legged terrestrial mammal. Why should we have arrector pili muscles in our skin that produce thoroughly useless gooseflesh? Because of our recent speciation from other apes whose arrector pili muscles were attached to hair, and whose hair stands up during emotional arousal.

And, irritatingly, bacteria are generating resistance to antibiotics we haven’t even thought of yet. For example, after placing a single bacterial species in a nutrient solution containing sublethal doses of a newly developed and rare antibiotic, researchers found that within a short period of time the bacteria developed resistance to that antibiotic and to twelve other antibiotics that they had never before encountered—some of which were structurally dissimilar to the first. Stuart Levy observes that “it’s almost as if bacteria strategically anticipate the confrontation of other drugs when they resist one.

In an extremely short period of geologic time the Earth has been saturated with several billion pounds of nonbiodegradable, often biologically unique pharmaceuticals designed to kill bacteria. Many antibiotics (literally meaning “against life”) do not discriminate in their activity, but kill broad groups of diverse bacteria whenever they are used. The worldwide environmental dumping, over the past 65 years, of such huge quantities of synthetic antibiotics has initiated the most pervasive impacts on the Earth’s bacterial underpinnings since oxygen-generating bacteria supplanted methanogens 2.5 billion years ago. As bacterial researcher Stuart Levy comments . . . It has stimulated evolutionary changes that are unparalleled in recorded biologic history.4

Life expectancy has increased primarily because of sanitation practices and infectious disease mitigation measures; because of emergency surgery techniques for acute and life-threatening conditions, like an inflamed appendix or trauma; and because of antibiotics to reverse life-threatening infections. In short, almost every “health miracle” we can point to is a cure for an acute issue (i.e., a problem that would kill you imminently if left unresolved). Economically, acute conditions aren’t great in our modern system, because the patient is quickly cured and no longer a customer. Starting in the 1960s, the medical system has taken the trust engendered by these acute innovations and used it to ask patients not to question its authority on chronic diseases (which can last a lifetime and thus are more profitable).

Every morning the whole team watched as the resident listened to the heart and lungs of each of our patients. Usually he said nothing because there was nothing to say. One morning while examining Richard he stopped and had each of us listen to a spot he had located on the patient’s back. “Those are rales and rhonchi,” he stated flatly. “Richard is coming down with pneumonia.” He had one of us write orders for a chest X-ray and massive doses of IV ampicillin. Four hours later Richard was short of breath, running a 105-degree fever, sick as a dog. The chest X-ray hadn’t been done and the antibiotics hadn’t been given. The one time we had a physical finding that might have made a difference on the closest thing we had to a salvageable patient, the damn orders were written but never taken off. Our resident was closer to tears than mad. Richard did well. If he had been eighty-five, he probably would have died.

Yet the homogeneity of contemporary humanity is most apparent when it comes to our view of the natural world and of the human body. If you fell sick a thousand years ago, it mattered a great deal where you lived. In Europe, the resident priest would probably tell you that you had made God angry and that in order to regain your health you should donate something to the church, make a pilgrimage to a sacred site, and pray fervently for God’s forgiveness. Alternatively, the village witch might explain that a demon had possessed you and that she could cast it out using song, dance, and the blood of a black cockerel. In the Middle East, doctors brought up on classical traditions might explain that your four bodily humors were out of balance and that you should harmonize them with a proper diet and foul-smelling potions. In India, Ayurvedic experts would offer their own theories concerning the balance between the three bodily elements known as doshas and recommend a treatment of herbs, massages, and yoga postures. Chinese physicians, Siberian shamans, African witch doctors, Amerindian medicine men—every empire, kingdom, and tribe had its own traditions and experts, each espousing different views about the human body and the nature of sickness, and each offering their own cornucopia of rituals, concoctions, and cures. Some of them worked surprisingly well, whereas others were little short of a death sentence. The only thing that united European, Chinese, African, and American medical practices was that everywhere at least a third of all children died before reaching adulthood, and average life expectancy was far below fifty.14 Today, if you happen to be sick, it makes much less difference where you live. In Toronto, Tokyo, Tehran, or Tel Aviv, you will be taken to similar-looking hospitals, where you will meet doctors in white coats who learned the same scientific theories in the same medical colleges. They will follow identical protocols and use identical tests to reach very similar diagnoses. They will then dispense the same medicines produced by the same international drug companies. There are still some minor cultural differences, but Canadian, Japanese, Iranian, and Israeli physicians hold much the same views about the human body and human diseases. After the Islamic State captured Raqqa and Mosul, it did not tear down the local hospitals. Rather, it launched an appeal to Muslim doctors and nurses throughout the world to volunteer their services there.15 Presumably even Islamist doctors and nurses believe that the body is made of cells, that diseases are caused by pathogens, and that antibiotics kill bacteria.

Shortly after I returned home from the Ukraine, I became severely ill with what doctors believed was a parasite. I couldn’t hold my food down and lost a lot of weight. Different doctors kept prescribing me antibiotics, but none of them seemed to help. For a couple of months, I was poked and tested in a variety of ways, only to have more questions surface than answers. Then I was sent to an ear, nose, and throat doctor for an evaluation. I was sitting in a waiting room with a bunch of toddlers, when my name was called. By the time I got into the examination room I knew I’d had enough. “Hey, I’m outta here,” I told the doctor. “I’ll take my chance with the resurrection.” Well, a couple of weeks later, my insurance agent called me. He was one of my lifelong friends and sounded concerned. “Hey, Jase,” he said. “Your insurance company wants you to see a psychiatrist.” Apparently, the ear, nose, and throat doctor recommended I undergo a full psychiatric evaluation based on my refusal to be examined, along with my speech on the resurrection! Apparently, he thought I was crazy. I convinced my buddy that I didn’t need a psychiatrist and eventually got over my illness. I would later read a passage of scripture in the Bible that caused me to smile in reflection on the entire ordeal. Second Corinthians 5:13 says: “If we are out of our mind, as some say, it is for God; if we are in our right mind, it is for you.

Nobel laureate Sir MacFarlane Burnet was moved from his perspective as an immunologist to issue similar warnings about humanity’s overconfidence. True, he said, vaccines and antibiotics had rendered most infectious diseases of the Northern Hemisphere controllable. But, he cautioned, “it is almost an axiom that action for short-term human benefit will sooner or later bring long-term ecological or social problems which demand unacceptable effort and expense for their solution. Nature has always seemed to be working for a climax state, a provisionally stable ecosystem, reached by natural forces, and when we attempt to remold any such ecosystem, we must remember that Nature is working against us.”43

We need to change the ways in which we talk about humanity and the environment and in order to do so, we need to change the way in which we think about them, not an easy task given that we use language to think and our languages make us conceive the environment as detached. A possible way out to help us approach problems, without being drawn back by the mental models that fail us, is Systems Dynamics (Meadows 2008; Sterman 2012). Unfortunately, Sterman explains, most efforts made by individuals and institutions to enhance sustainability are directed at the symptoms and not at the causes and systems (any system) will respond to any change introduced with what is known as ‘policy resistance’, that is the existing system will tend to react to change in ways that we had not intended when we first designed the intervention (a few examples are road-building programs designed to reduce congestion that ends up increasing traffic or antibiotics that stimulate the evolution of drug-resistant pathogens—for a longer list and further explanation see Sterman 2012, 24). Systems Dynamics allows us to calculate scientifically the way in which a complex system will react to change and to account beforehand for what we usually describe as ‘side-effects’. Side effects, Sterman argues, ‘are not a feature of reality but a sign that the boundaries of our mental models are too narrow, our time horizons too short’ (24). As Gonella et al. (2019) explain: ”As long as we consider the geobiosphere as a sub-system (a resources provider) of the human-made economic system, any attempt to fix environmental and social problems by keeping the business as usual, i.e., the mantra of economic growth, will fail. The reality tells us the reverse: geobiosphere is not a sub-system of the economy, economy is a sub-system of geobiosphere. As systems thinkers know, trying to keep alive at any cost the operation of a sub-system will give rise to a re-arrangement of the super-system – the geobiosphere – that will self-reorganize to absorb and make ineffective our attempt, then continuing its own way.” (Gonella et al. 2019)

Over the next couple of years, Cole and the rest of psychiatry settled on a trial design for testing psychotropic drugs. Psychiatrists and nurses would use “rating scales” to measure numerically the characteristic symptoms of the disease that was to be studied. Did a drug for schizophrenia reduce the patient’s “anxiety”? His or her “grandiosity”? “Hostility”? “Suspiciousness”? “Unusual thought content”? “Uncooperativeness”? The severity of all of those symptoms would be measured on a numerical scale and a total “symptom” score tabulated, and a drug would be deemed effective if it reduced the total score significantly more than a placebo did within a six-week period. At least in theory, psychiatry now had a way to conduct trials of psychiatric drugs that would produce an “objective” result. Yet the adoption of this assessment put psychiatry on a very particular path: The field would now see short-term reduction of symptoms as evidence of a drug’s efficacy. Much as a physician in internal medicine would prescribe an antibiotic for a bacterial infection, a psychiatrist would prescribe a pill that knocked down a “target symptom” of a “discrete disease.” The six-week “clinical trial” would prove that this was the right thing to do. However, this tool wouldn’t provide any insight into how patients were faring over the long term. Were they able to work? Were they enjoying life? Did they have friends? Were they getting married? None of those questions would be answered. This was the moment that magic-bullet medicine shaped psychiatry’s future. The use of the clinical trial would cause psychiatrists to see their therapies through a very particular prism, and even at the 1956 conference, New York State Psychiatric Institute researcher Joseph Zubin warned that when it came to evaluating a therapy for a psychiatric disorder, a six-week study induced a kind of scientific myopia. “It would be foolhardy to claim a definite advantage for a specified therapy without a two- to five-year follow-up,” he said. “A two-year follow-up would seem to be the very minimum for the long-term effects.

In the privacy of my room, armed with a mirror, shaving cream, razor, and bowl of water, I sat on my floor with a towel propped under my bare ass. Leaning back against my bed with my legs wide open as if I were about to give birth, I shaved everything off. My lady parts looked like a barren desert after a massive forest fire. I saw parts of myself that had long vanished beneath pubescent growth. Suddenly, I felt sexy. There was something about going bare that made me feel sensual and touchable. But that was short lived. I was ill prepared for my skin’s reaction to the change. I completely broke out. My pussy flushed as razor bumps shot across my flesh as if I’d had an allergic reaction to my underwear. It took weeks of applying antibiotic ointment to calm my skin.

It should be clear by now that even short-term antibiotic treatments can lead to long-term shifts in the microbes colonizing our bodies. A full recovery or bounce-back of healthy bacteria is in no way guaranteed, despite the long-held belief that such was the case. But that is not my only worry. I also fear that some of our residential organisms—what I think of as contingency species—may disappear altogether.

We live in a world where we consider pain to be, largely, an avoidable experience. Worldwide, the over-the-counter analgesic market was worth over US$30 billion in 2007. For many of us, even a mild headache or sprain has us reaching for the paracetamol (acetaminophen) or the ibuprofen. Yet, a little over a century and a half ago, things were very different. For most people, especially poor people, pain was more or less a daily experience. There were no readily available analgesics, which meant that pain of all kinds simply had to be endured. Poor nutrition, poor sanitation, overcrowding, and unsafe working conditions created an environment in which problems like rickets, abscesses, and toothache flourished. In the absence of pain relief, childbirth was a dreaded experience for many women. Occasionally, a person would be suffering so dreadfully from pain that he or she would submit to surgery, without any form of anaesthetic. A limb crushed by the wheel of a cart would, in the absence of antibiotics, quickly turn gangrenous and cause the death of its owner – if not swiftly amputated.

as soon as you sign a commitment and post it on your wall, you’ve created a mental cost for writing an unnecessary prescription. If you’re tempted to write that script, you’ll now be hyperaware that doing so means breaking your word. After all, you signed your name to a framed letter promising not to do this very thing. In short, the “price” of prescribing an unnecessary antibiotic has gone up.

But my favourite cautionary tale is of Australian junior doctor Barry Marshall and his pathologist colleague Robin Warren. In the early 1980s they disagreed with the general medical consensus that most stomach ulcers were caused by stress, bad diet, alcohol, smoking and genetic factors. Instead Marshall and Warren were convinced that a particular bacterium, Helicobacter pylori, was the cause. And if they were right, the solution to many patients’ ulcers could be a simple course of antibiotics, not the risky stomach surgery that was often on the cards. Barry must have picked the short straw, because instead of setting up a test on random members of the public – and having to convince those well-known fun-skewerers of human trials: ethics committees – he just went ahead and swallowed a bunch of the little bugs. Imagine the joy, as his hypothesis was proved right! Imagine the horror, as his stomach became infected, which led to gastritis, the first stage of the stomach ulcers! Imagine his poor wife and family, as the vomiting and halitosis became too much to bear! Dr Marshall lasted 14 days before taking antibiotics to kill the H. pylori, but it was another 20 years before he and Warren were awarded the 2005 Nobel Prize for Physiology or Medicine. So, hang on, is self-experimenting really that bad if it wins you a Nobel Prize? I guess you can only have a go and find out…but please don’t go as far as US army surgeon Jesse Lazear: in trying to prove that yellow fever was contagious, and that infected blood could be transferred via mosquito bites, he was bitten by one and died. The mosquito that caused his death might not even have been part of his experiment. It’s thought that it could just have been a local specimen. But one that enjoyed both biting humans and dramatic irony. Gastrointestinal elements

Subway restaurants agreed to remove the “yoga mat chemical” from their bread following a petition I started.1 Kraft decided to remove artificial food dyes from their kids’ mac and cheese products after I stormed their headquarters with over 200,000 petitions.2 Chick-fil-A’s chicken went antibiotic free following my meetings with them urging them to do so.3 Anheuser-Busch and Miller-Coors both agreed to publish their ingredients for the first time in history following another of my petitions.4 I was finishing up my first book, exposing the chemicals in our food, and it was slated to be out in a few short months. I had just published an investigation into Starbucks’ famous Pumpkin Spice Latte,5 calling them out for their use of “class IV” caramel coloring (a chemical linked to cancer).6 This piece went viral, with millions of views and shares (which ultimately led to Starbucks dropping this coloring from their drinks).

From the wheel to the steel - from papyrus to kindle - from churchbell to doorbell - from holy books to comic books - from monotheism to secularism - from fundamentalism to humanism - from steam engine to jet engine - from cave painting to apple pencil - from antibiotics to antipsychotics - from embroidery to surgery - from moving pics to netflix - every single feat that we can think of, good or bad, is born of the neurons. In short, neurons can make the world or break the world.

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In Yakutia, where the earth’s largest thermokarst—the “Batagai Depression”—a kilometer in length, 100 meters deep and still growing rapidly, is also the site for scientists who are gathering samples of preserved and frozen soils up to 200,000 years old. Using molecular genetic and microbiological procedures they hope to extract bacteria and viruses from the soils that could lead to new antibiotics. But for the third straight year terrible fires are devouring the forests of Yakutia. The smoke drifts out into the Pacific and people on ships and in Alaska and along the North American west coast cough and gasp in the pungent brown haze.