Pathophysiology Quotes

33,3% of the mice used in this experiment were cured by the test drug; 33,3% of the population were unaffected by the drug and remained in a moribund condition; the third mouse got away.

The pathophysiological consequences of ME/CFS are multi-systemic and may include: immune and neuroendocrine abnormalities; brain dysfunction and neurocognitive defects; cardiovascular and autonomic disturbances; abnormalities in energy production including mitochondrial dysfunction, and changes in the expression of certain genes.

...exercise has not been shown to produce a long term cure for ME/CFS and studies have not shown that exercise reverses the pathophysiological changes found in this illness... ...for many patients, adding an injudicious exercise program has caused post exertional malaise and deterioration of function

For one thing, psychiatric diseases are not considered diseases at all. Diseases are based on knowledge of the cause (or etiology) of a particular disorder and the effects (or pathophysiology) they have on the body. Unlike for many true diseases of other organ systems, we don’t have this luxury with diseases of the mind since so little is known of the underlying pathological biological mechanisms at work. Despite advances in our understanding of how the brain works, the organ is still largely a mystery to us. Therefore, most psychiatric problems are called disorders or syndromes. Psychopathy stands on the lowest rung of this disease-disorder ladder, since no one agrees on what defines it—or if it exists at all— and so there is no professional agreement as to the underlying causes.

Does it surprise you that Alzheimer’s disease is referred to as “type III diabetes” by virtue of their similar pathophysiology? It shouldn’t. Nor should the preventable nature of these diseases. So

Physiology at MIT recognized that the richness and detail of the collected data opened the feasibility of creating a new generation of monitoring systems to track the physiologic state of the patient, employing the power of modern signal processing, pattern recognition, computational modeling, and knowledge-based clinical reasoning. In the long term, we hoped to design monitoring systems that not only synthesized and reported all relevant measurements to clinicians, but also formed pathophysiologic hypotheses that best explained the observed data. Such systems would permit early detection of complex problems, provide useful guidance on therapeutic interventions, and ultimately lead to improved patient outcomes.

This migration to higher transport property is induced by vascular endothelial growth factor (VEGF), analogous to the pathophysiology of diabetic retinopathy.

Even as I approached the emergency room that first night, my thoughts were the measured, structured thoughts of a physician. I was unable to relate to myself as a patient. Presented with the problem of pain, I responded by listing differential diagnoses and prognosticating for myself. When I found myself dizzy and unable to stand in OB triage, the physician in me perversely enjoyed experiencing shock firsthand. The intensity of my focus on medicine was such that I felt fortunate to have the learning opportunity, to personally engage with the pathophysiology I had studied for so long. I knew I was dying, and I was still awestruck by the science of my decline.

Pathophysiological effects of dysbiosis are becoming clearer, but knowledge has not yet translated to development of new therapies (Am J Gastroenterol 2015;110:1399).

understand bubbles and crashes in the same way. For example, their pathophysiology involves the vagaries of human psychology and the unstable supply of credit from a modern banking system. Their anatomy consists of the “four ps”: promoters, public, politicians, and press. Finally, their signs and symptoms include the contagious societal infatuation with nearly effortless wealth, the hubris of the promoters, and their veneration by the public.366

some other property, such as hormone production, which is more highly developed in other cells. The eight chief cellular functions are as follows: • Movement. Muscle cells can generate forces that produce motion. Muscles that attach to bones produce limb movements, whereas muscles that enclose hollow

In short, no psychiatric diagnosis is, or can be, pathology-driven; instead, all such diagnoses are driven by nonmedical (economic, personal, legal, political, and social) factors or incentives. Accordingly, psychiatric diagnoses do not point to pathoanatomic or pathophysiological lesions and do not identify causative agents—but rather refer to human behaviors. Moreover, the psychiatric terms used to refer to such behaviors allude to the plight of the denominated patient, hint at the dilemmas with which patient and psychiatrist alike try to cope as well as exploit, and mirror the beliefs and values of the society that both inhabit.

The pathophysiology of drowning went like this: two conscious people who slipped underwater would first hold their breath. They would understand that the air existed above the surface and would try to get to it. They would struggle and fight. This would use up the oxygen that was stored in their bodies, rendering them unconscious in thirty to sixty seconds. Even if their hearts stopped beating, the damage done within those sixty seconds would not be irreversible.

Reproductive hormones and serotonin, stress hormones and neurotransmitters. The whole rickety biological pathophysiology of our women. The PMDD women, maybe all women. She sees the dangerous relays in the suffering body. She understands the mad pulses of the blood.

that needs to be reached in order to tip the balance toward APP’s anti-Alzheimer’s pathway. What this means is that you don’t have to address all thirty-six holes. When you have patched enough of them, the rest aren’t serious enough to let much water into your house. If we leave our roofing analogy to get back to Alzheimer’s, the presence of a few of the factors nudging APP down the Alzheimer’s-causing pathway isn’t enough to exert that nudge in enough of your brain neurons enough of the time to cause Alzheimer’s. Unfortunately, we don’t yet have a simple way to measure how many of the thirty-six each person can safely live with, and each hole is a different size for each person, depending on his/her genetics and biochemistry, so it’s best to address as many as you can until you see improvement. This is in fact what happens in the treatment of cardiovascular disease. When you address enough of the key pathophysiological parameters, like lowering your blood levels of triglycerides and reaching a healthy weight, you reverse cardiovascular disease, eliminating arterial plaque, as Dr. Dean Ornish has shown. Even if you do not patch all of the cardiovascular holes—maybe you still have an imperfect diet or some mild stress

KeywordsBig data​ – ​Confounding variables​ – ​Residual confounding​ – ​Selection bias​ – ​Pathophysiology​ – ​Propensity scores Take Home Messages Any observational study may have unidentified confounding variables that influence the effects of the primary exposure, therefore we must rely on research transparency along with thoughtful and careful examination of the limitations to

In 2016 Neurotrack released the Imprint Cognitive Assessment Test, a five-minute web-based visual cognitive assessment that, by tracking eye movements, detects which objects and other stimuli people recognize as novel. It thus detects impairment of the hippocampus and nearby structures, identifying people who have dysfunction of this region and may be manifesting the pathophysiology of Alzheimer’s disease. GOAL:

The evidence to support cutting out meat consumption is very strong. From studies showing pathophysiologic changes (doctor-speak for “bad stuff happening in the body”) associated with animal consumption that hypothetically could cause heart disease, to epidemiologic studies to randomized control trials, it’s easy to see that the less animal protein, the happier your heart.

There was little precedent in other diseases for such an astonishing diversity of causes. Diabetes, a complex illness with complex manifestations, is still fundamentally a disease of abnormal insulin signaling. Coronary heart disease occurs when a clot, arising from a ruptured and inflamed atherosclerotic plaque, occludes a blood vessel of the heart. But the search for a unifying mechanistic description of cancer seemed to be sorely missing. What, beyond abnormal, dysregulated cell division, was the common pathophysiological mechanism underlying cancer? To answer this question, cancer biologists would need to return to the birth of cancer, to the very first steps of a cell’s journey toward malignant transformation—to carcinogenesis.

Thus, homeostatic compensations that ensue after injury, disease, or major environmental challenges to the body may represent a “trade-off” that is necessary to maintain vital body functions but may, in the long term, contribute to additional abnormalities of body function. The discipline of pathophysiology seeks to explain how the various physiological processes are altered in diseases or injury.

The label ‘chronic fatigue syndrome’ (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term ‘myalgic encephalomyelitis’ (ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization’s International Classification of Diseases (ICD G93.3).