Organic Chemistry Quotes

Learning organic chemistry is not any more challenging than getting to know some new characters. The elements each have their own unique personalities. The more you understand those personalities, the more you will be able to read their situations and predict the outcomes of reactions.” —Kathleen Nolta, Ph.D., Senior Lecturer in Chemistry

Let us learn to dream, gentlemen, then perhaps we shall find the truth

[R]eligion was the race's first (and worst) attempt to make sense of reality. It was the best the species could do at a time when we had no concept of physics, chemistry, biology or medicine. We did not know that we lived on a round planet, let alone that the said planet was in orbit in a minor and obscure solar system, which was also on the edge of an unimaginably vast cosmos that was exploding away from its original source of energy. We did not know that micro-organisms were so powerful and lived in our digestive systems in order to enable us to live, as well as mounting lethal attacks on us as parasites. We did not know of our close kinship with other animals. We believed that sprites, imps, demons, and djinns were hovering in the air about us. We imagined that thunder and lightning were portentous. It has taken us a long time to shrug off this heavy coat of ignorance and fear, and every time we do there are self-interested forces who want to compel us to put it back on again.

But the problem was, Sacks wasn’t comparing herself to all the students in the world taking Organic Chemistry. She was comparing herself to her fellow students at Brown. She was a Little Fish in one of the deepest and most competitive ponds in the country—and the experience of comparing herself to all the other brilliant fish shattered her confidence. It made her feel stupid, even

There is no essential self that lies pure as a vein of gold under the chaos of experience and chemistry. Anything can be changed, and we must understand the human organism as a sequence of selves that succumb to or choose one another.

I hope that in due time the chemists will justify their proceedings by some large generalisations deduced from the infinity of results which they have collected. For me I am left hopelessly behind and I will acknowledge to you that through my bad memory organic chemistry is to me a sealed book. Some of those here, Hofmann for instance, consider all this however as scaffolding, which will disappear when the structure is built. I hope the structure will be worthy of the labour. I should expect a better and a quicker result from the study of the powers of matter, but then I have a predilection that way and am probably prejudiced in judgment.

​Briefly, the Indiana biochemists encouraged me to learn organic chemistry, but after I used a bunsen burner to warm up some benzene, I was relieved from further true chemistry. It was safer to turn out an uneducated Ph.D. than to risk another explosion.

Life is simply a particular state of organized instability.

think, for example, has a higher suicide rate: countries whose citizens declare themselves to be very happy, such as Switzerland, Denmark, Iceland, the Netherlands, and Canada? or countries like Greece, Italy, Portugal, and Spain, whose citizens describe themselves as not very happy at all? Answer: the so-called happy countries. It’s the same phenomenon as in the Military Police and the Air Corps. If you are depressed in a place where most people are pretty unhappy, you compare yourself to those around you and you don’t feel all that bad. But can you imagine how difficult it must be to be depressed in a country where everyone else has a big smile on their face?2 Caroline Sacks’s decision to evaluate herself, then, by looking around her organic chemistry classroom was not some strange and irrational behavior. It is what human beings do. We compare ourselves to those in the same situation as ourselves, which means that students in an elite school—except, perhaps,

You have to make your own condensed notes. You learn from MAKING them. A lot of thinking goes into deciding what to include and exclude. You develop your own system of abbreviations and memory methods for the information.

Different sorts of survival machine appear very varied on the outside and in their internal organs. An octopus is nothing like a mouse, and both are quite different from an oak tree. Yet in their fundamental chemistry they are rather uniform, and, in particular, the replicators that they bear, the genes, are basically the same kind of molecule in all of us—from bacteria to elephants. We are all survival machines for the same kind of replicator—molecules called DNA— but there are many different ways of making a living in the world, and the replicators have built a vast range of machines to exploit them. A monkey is a machine that preserves genes up trees, a fish is a machine that preserves genes in the water; there is even a small worm that preserves genes in German beer mats. DNA works in mysterious ways.

Sometimes I rode the Circle Line reading a book on organic chemistry and sometimes I read Leave It to Psmith for the 20th or 21st time and sometimes I watched Jeremy Brett's marvellous grotesque Sherlock Holmes or of course Seven Samurai. I sometimes went out for Tennessee Fried Chicken. Day followed day. A year went by.

If you took organic chemistry in college, you’ve experienced the Dip. Academia doesn’t want too many unmotivated people to attempt medical school, so they set up a screen. Organic chemistry is the killer class, the screen that separates the doctors from the psychologists. If you can’t handle organic chemistry, well, then, you can’t go to med school.

The elements were from my mother’s own version of organic chemistry. Each person is made of five elements, she told me.

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired. Evolution has produced chemical compounds exquisitely organized to accomplish the most complicated and delicate of tasks. Many organic chemists viewing crystal structures of enzyme systems or nucleic acids and knowing the marvels of specificity of the immune systems must dream of designing and synthesizing simpler organic compounds that imitate working features of these naturally occurring compounds.

The cell, this elementary keystone of living nature, is far from being a peculiar chemical giant molecule or even a living protein and as such is not likely to fall prey to the field of an advanced chemistry. The cell is itself an organism, constituted of many small units of life.

Life may be chemistry, but it's a special circumstance of chemistry. Organisms exist not because of reactions that are possible, but because of reactions that are barely possible. Too much reactivity and we would spontaneously combust. Too little, and we would turn cold and die. Proteins enable these barely possible reactions, allowing us to live on the edges of chemical entropy-skating perilously, but never falling in.

But the problem was, Sacks wasn’t comparing herself to all the students in the world taking Organic Chemistry. She was comparing herself to her fellow students at Brown. She was a Little Fish in one of the deepest and most competitive ponds in the country—and the experience of comparing herself to all the other brilliant fish shattered her confidence. It made her feel stupid, even though she isn’t stupid at all. “Wow, other people are mastering this, even people who were as clueless as I was in the beginning, and I just can’t seem to learn to think in this manner.

A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.

Eliot, huh?" she says. The thin fabric of her long T-shirt brushes my arm. "Is everyone in your family named for a famous symbolist poet?" No, I'm named for someone who was supposed to be in the Bible but isn't." No? What happened to him?" I glance over at her, the way the corner of her mouth turns up, half-smirk, half-smile. Her hair moves as she walks. He was called to be a disciple, but he had, you know, stuff to do." Stuff, like...polishing his sandals? Making lunch?" We keep walking, over the bridge across the lake, past the swings and the playground equipment, just walking. Exactly. And what about you, Calliope...is everyone in your family named after a...what is it? A keyboard? An organ?" It's a steam-powered piano. It's also the name of the Greek goddess of poetry. You should read stuff other than chemistry; you'd know these things." Her smirky smile again, her sleeve touching my arm. I feel like my skin has been removed, every nerve exposed. I open my mouth, and this comes out: "I think you are more goddess than piano." Stupid, stupid. But she laughs. "You know, that's the nicest thing anyone's said to me today." You don't see too many calliopes," I tell her. I'm Cal, actually. I mean, that's what I prefer." I meant the steam pianos...you don't see too many." She stops and looks at me, full-on, and right away I put it on the list of the best moments in my life. Until you said that, Eliot, I wasn't fully aware of the demise of the steam piano, so thank you. Really." I smirk at her and we both fight not to smile. "Okay, smart-ass," I say.

WHY is ocean acidification so dangerous? The question is tough to answer only because the list of reasons is so long. Depending on how tightly organisms are able to regulate their internal chemistry, acidification may affect such basic processes as metabolism, enzyme activity, and protein function. Because it will

Exactly. And what about you, Calliope...is everyone in your family named after a...what is it? A keyboard? An organ?" It's a steam-powered piano. It's also the name of the Greek goddess of poetry. You should read stuff other than chemistry; you'd know these things." Her smirky smile again, her sleeve touching my arm. I feel like my skin has been removed, every nerve exposed. I open my mouth, and this is what comes out: "I think you are more goddess than piano." Stupid, stupid. But she laughs. "You know, that's the nicest thing anyone's said to me today." You don't see too many calliopes," I tell her I'm Cal, actually. I mean, that's what I prefer." I meant the steam pianos...you don't see too many." She stops and looks at me, full-on, and right away I put it on the list of the best moments in my life. Until you said that, Eliot, I wasn't fully aware of the demise of the steam piano, so thank you. Really." I smirk at her and we both fight not to smile. "Okay, smart-ass," I say. Callipe and Eliot-Scrambeled Eggs at Midnight

In 1902, Marcellin P. Berthelot, often called the founder of modern organic chemistry, was one of France's most celebrated scientists—if not the world's. He was permanent secretary of the French Academy, having succeeded the giant Louis Pasteur, the renowned microbiologist. Unlike Delage, an agnostic, Berthelot was an atheist—and militantly so.

She handed Mrs. Hines, the librarian, a list of college textbooks. “Could you please help me find The Principles of Organic Chemistry by Geissman, Invertebrate Zoology of the Coastal Marsh by Jones, and Fundamentals of Ecology by Odum . . .” She’d seen these titles referenced in the last of the books Tate had given before he left her for college.

Third, we never say fairy godfathers. The fairy person is always female.” “Because of organized crime?” Madeline asked.

We never say fairy godfathers. The fairy person is always female. Because of organized crime?

convinced the baby was snatching her internal organs like suitcases as if to ensure she’d have plenty to wear on the outside,

In the Gaia theory air, water, and soil are major components of one central organism, planet Earth. What we typically think of as life - the plants and animals that inhabit the earth - has evolved merely to regulate the chemistry of the biosphere. Humans are insignificant participants, far less important to the life cycle than termites. Even the imbalance that we have created by adding massive quantities of carbon dioxide to the atmosphere may be brought back to acceptable levels by other organisms functioning in their capacity to correct excesses.

All my life I have wondered about the possibility of life elsewhere. What would it be like? Of what would it be made? All living things on our planet are constructed of organic molecules—complex microscopic architectures in which the carbon atom plays a central role. There was once a time before life, when the Earth was barren and utterly desolate. Our world is now overflowing with life. How did it come about? How, in the absence of life, were carbon-based organic molecules made? How did the first living things arise? How did life evolve to produce beings as elaborate and complex as we, able to explore the mystery of our own origins? And on the countless other planets that may circle other suns, is there life also? Is extraterrestrial life, if it exists, based on the same organic molecules as life on Earth? Do the beings of other worlds look much like life on Earth? Or are they stunningly different—other adaptations to other environments? What else is possible? The nature of life on Earth and the search for life elsewhere are two sides of the same question—the search for who we are. In the great dark between the stars there are clouds of gas and dust and organic matter. Dozens of different kinds of organic molecules have been found there by radio telescopes. The abundance of these molecules suggests that the stuff of life is everywhere. Perhaps the origin and evolution of life is, given enough time, a cosmic inevitability. On some of the billions of planets in the Milky Way Galaxy, life may never arise. On others, it may arise and die out, or never evolve beyond its simplest forms. And on some small fraction of worlds there may develop intelligences and civilizations more advanced than our own. Occasionally someone remarks on what a lucky coincidence it is that the Earth is perfectly suitable for life—moderate temperatures, liquid water, oxygen atmosphere, and so on. But this is, at least in part, a confusion of cause and effect. We earthlings are supremely well adapted to the environment of the Earth because we grew up here. Those earlier forms of life that were not well adapted died. We are descended from the organisms that did well. Organisms that evolve on a quite different world will doubtless sing its praises too. All life on Earth is closely related. We have a common organic chemistry and a common evolutionary heritage. As a result, our biologists are profoundly limited. They study only a single kind of biology, one lonely theme in the music of life. Is this faint and reedy tune the only voice for thousands of light-years? Or is there a kind of cosmic fugue, with themes and counterpoints, dissonances and harmonies, a billion different voices playing the life music of the Galaxy? Let

Only three of the naturally occurring elements were manufactured in the big bang. The rest were forged in the high-temperature hearts and explosive remains of dying stars, enabling subsequent generations of star systems to incorporate this enrichment, forming planets and, in our case, people. For many, the Periodic Table of Chemical Elements is a forgotten oddity—a chart of boxes filled with mysterious, cryptic letters last encountered on the wall of high school chemistry class. As the organizing principle for the chemical behavior of all known and yet-to-be-discovered elements in the universe, the table instead ought to be a cultural icon, a testimony to the enterprise of science as an international human adventure conducted in laboratories, particle accelerators, and on the frontier of the cosmos itself.

Every branch of science likes to think it’s important, and of course, they all are. But they’re specializations. Much of biology, for example, is biochemistry, which is a specialization of organic chemistry, which is a specialization of chemistry, which is a specialization of physics, and physics is practical mathematics. No matter which set of matryoshka dolls you open in science, the innermost is always math.

Three worlds emerge as the top candidates for occupying this new Goldilocks sweet spot. Europa and Enceladus may have the right combination of liquid water, elements, and energy needed to give rise to life and power life as we know it. Lastly, Titan, although perhaps too large to have a rocky seafloor, is flush with carbon and interesting organic chemistry that make it hard to resist when it comes to the prospect of life.

These guys weren't just shmucks off the street. They had a reputation for being right about stuff. According to some histories, Berzelius is the scientist who first called molecules that contained only carbon, hydrogen, oxygen, and nitrogen "organic," because they're found in living things -- thus inventing "organic chemistry," the college course that destroys the hopes of so many kids who think they're going to be doctors.

When she was in labor and in horrific pain, convinced the baby was snatching her internal organs like suitcases as if to ensure she’d have plenty to wear on the outside, she screamed so violently the bed frame shook.

He used his intellect as he used his legs: to carry him somewhere else. He studied astrology, astronomy, botany, chemistry, numerology, fortification, divination, organ building, metallurgy, medicine, perspective, the kabbala, toxicology, philosophy, and jurisprudence. He kept his interest in anatomy and did a dissection whenever he could get hold of a body. He learned Arabic, Catalan, Polish, Icelandic, Basque, Hungarian, Romany, and demotic Greek.

Steps for Problem-Solving Know your nomenclature. Identify the functional groups. Identify the other reagents. Identify the most reactive functional group(s). Identify the first step of the reaction. Consider stereoselectivity.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.

The next time you drive into a Walmart parking lot, pause for a second to note that this Walmart—like the more than five thousand other Walmarts across the country—costs taxpayers about $1 million in direct subsidies to the employees who don’t earn enough money to pay for an apartment, buy food, or get even the most basic health care for their children. In total, Walmart benefits from more than $7 billion in subsidies each year from taxpayers like you. Those “low, low prices” are made possible by low, low wages—and by the taxes you pay to keep those workers alive on their low, low pay. As I said earlier, I don’t think that anyone who works full-time should live in poverty. I also don’t think that bazillion-dollar companies like Walmart ought to funnel profits to shareholders while paying such low wages that taxpayers must pick up the ticket for their employees’ food, shelter, and medical care. I listen to right-wing loudmouths sound off about what an outrage welfare is and I think, “Yeah, it stinks that Walmart has been sucking up so much government assistance for so long.” But somehow I suspect that these guys aren’t talking about Walmart the Welfare Queen. Walmart isn’t alone. Every year, employers like retailers and fast-food outlets pay wages that are so low that the rest of America ponies up a collective $153 billion to subsidize their workers. That’s $153 billion every year. Anyone want to guess what we could do with that mountain of money? We could make every public college tuition-free and pay for preschool for every child—and still have tens of billions left over. We could almost double the amount we spend on services for veterans, such as disability, long-term care, and ending homelessness. We could double all federal research and development—everything: medical, scientific, engineering, climate science, behavioral health, chemistry, brain mapping, drug addiction, even defense research. Or we could more than double federal spending on transportation and water infrastructure—roads, bridges, airports, mass transit, dams and levees, water treatment plants, safe new water pipes. Yeah, the point I’m making is blindingly obvious. America could do a lot with the money taxpayers spend to keep afloat people who are working full-time but whose employers don’t pay a living wage. Of course, giant corporations know they have a sweet deal—and they plan to keep it, thank you very much. They have deployed armies of lobbyists and lawyers to fight off any efforts to give workers a chance to organize or fight for a higher wage. Giant corporations have used their mouthpiece, the national Chamber of Commerce, to oppose any increase in the minimum wage, calling it a “distraction” and a “cynical effort” to increase union membership. Lobbyists grow rich making sure that people like Gina don’t get paid more. The

Wöhler’s experiment demolished vitalism. Organic and inorganic chemicals, he proved, were interchangeable. Biology was chemistry: perhaps even a human body was no different from a bag of busily reacting chemicals—a beaker with arms, legs, eyes, brain, and soul.

Somewhere in all this, it was thought, there also resided a mysterious élan vital, the force that brought inanimate objects to life. No-one knew where this ethereal essence lay, but two things seemed probable: that you could enliven it with a jolt of electricity (a notion Mary Shelley exploited to full effect in her novel Frankenstein); and that it existed in some substances but not others, which is why we ended up with two branches of chemistry4: organic (for those substances that were thought to have it) and inorganic (for those that did not).

The housecleaning our bodies perform while we sleep is powered by the shakti that energizes the sympathetic, parasympathetic, and autonomous nervous systems to send instructions to the lymphatic system, the pituitary gland, and a host of other places in our slumbering forms. Whether it is blood circulating in the veins and arteries, a nerve impulse jumping a synaptic gap in the brain, our body straining while running the hundred-meter dash, or the working out of a physics or organic chemistry problem, our shakti provides the energy to accomplish the activity.

The end-Permian extinction also seems to have been triggered by a change in the climate. But in this case, the change went in the opposite direction. Right at the time of extinction, 252 million years ago, there was a massive release of carbon into the air—so massive that geologists have a hard time even imagining where all the carbon could have come from. Temperatures soared—the seas warmed by as much as eighteen degrees—and the chemistry of the oceans went haywire, as if in an out-of-control aquarium. The water became acidified, and the amount of dissolved oxygen dropped so low that many organisms probably, in effect, suffocated.

Life may be chemistry, but it’s a special circumstance of chemistry. Organisms exist not because of reactions that are possible, but because of reactions that are barely possible. Too much reactivity and we would spontaneously combust. Too little, and we would turn cold and die. Proteins enable these barely possible reactions, allowing

The ceiling is actually the jungle that keeps most people away from the hidden treasure. And if you’re ready to work on the skills category of your Career Savings Account, this is a tremendous gift. Author Seth Godin calls it the “Dip.” He says, “The Dip is the set of artificial screens set up to keep people like you out. If you took organic chemistry in college, you’ve experienced the Dip. Academia doesn’t want too many unmotivated people to attempt medical school, so they set up a screen. Organic chemistry is the killer class, the screen that separates the doctors from the psychologists. If you can’t handle organic chemistry, well, then you can’t go to med school.”2

that you could enliven it with a jolt of electricity (a notion Mary Shelley exploited to full effect in her novel Frankenstein) and that it existed in some substances but not others, which is why we ended up with two branches of chemistry: organic (for those substances that were thought to have it) and inorganic (for those that did not).

Scientists who had worked on the atom bomb added their voices to the growing movement. George Kistiakowsky, a Harvard University chemistry professor who had worked on the first atomic bomb, and later was science adviser to President Eisenhower, became a spokesman for the disarmament movement. HIs last public remarks, before his death from cancer at the age of eighty-two, were in an editorial for the Bulletin of Atomic Scientist in December 1982. "I tell you as my parting words: Forget the channels. There simply is not enough time left before the world explodes. Concentrate instead on organizing, with so many others of like mind, a mass movement for peace such as there has not been before.

This is one of the most fantastic pieces of detective work that has ever been done—organic chemistry. To discover the arrangement of the atoms in these enormously complicated arrays the chemist looks at what happens when he mixes two different substances together. The physicist could never quite believe that the chemist knew what he was talking about when he described the arrangement of the atoms. For about twenty years it has been possible, in some cases, to look at such molecules (not quite as complicated as this one, but some which contain parts of it) by a physical method, and it has been possible to locate every atom, not by looking at colors, but by measuring where they are. And lo and behold!, the chemists are almost always correct.

Here I should issue a caveat. In origins-of-life research (and probably in most other disciplines as well), scientists gravitate to models that highlight their personal scientific specialty. Organic chemist Stanley Miller and his cohorts saw life’s origins as essentially a problem in organic chemistry. Geochemists, by contrast, have tended to focus on more intricate origins scenarios involving such variables as temperature and pressure and chemically complex rocks. Experts in membrane-forming lipid molecules promote the “lipid world,” while molecular biologists who study DNA and RNA view the “RNA world” as the model to beat. Specialists who study viruses, or metabolism, or clays, or the deep biosphere have their idiosyncratic prejudices as well. We all do it; we all focus

ABOUT 14 BILLION YEARS AGO, MATTER, energy, time and space came into being in what is known as the Big Bang. The story of these fundamental features of our universe is called physics. About 300,000 years after their appearance, matter and energy started to coalesce into complex structures, called atoms, which then combined into molecules. The story of atoms, molecules and their interactions is called chemistry. About 4 billion years ago, on a planet called Earth, certain molecules combined to form particularly large and intricate structures called organisms. The story of organisms is called biology. About 70,000 years ago, organisms belonging to the species Homo sapiens started to form even more elaborate structures called cultures. The subsequent development of these human cultures is called history.

We may regard the cell quite apart from its familiar morphological aspects, and contemplate its constitution from the purely chemical standpoint. We are obliged to adopt the view, that the protoplasm is equipped with certain atomic groups, whose function especially consists in fixing to themselves food-stuffs, of importance to the cell-life. Adopting the nomenclature of organic chemistry, these groups may be designated side-chains. We may assume that the protoplasm consists of a special executive centre (Leistungs-centrum) in connection with which are nutritive side-chains... The relationship of the corresponding groups, i.e., those of the food-stuff, and those of the cell, must be specific. They must be adapted to one another, as, e.g., male and female screw (Pasteur), or as lock and key (E. Fischer).

Technology, I said before, is most powerful when it enables transitions—between linear and circular motion (the wheel), or between real and virtual space (the Internet). Science, in contrast, is most powerful when it elucidates rules of organization—laws—that act as lenses through which to view and organize the world. Technologists seek to liberate us from the constraints of our current realities through those transitions. Science defines those constraints, drawing the outer limits of the boundaries of possibility. Our greatest technological innovations thus carry names that claim our prowess over the world: the engine (from ingenium, or “ingenuity”) or the computer (from computare, or “reckoning together”). Our deepest scientific laws, in contrast, are often named after the limits of human knowledge: uncertainty, relativity, incompleteness, impossibility. Of all the sciences, biology is the most lawless; there are few rules to begin with, and even fewer rules that are universal. Living beings must, of course, obey the fundamental rules of physics and chemistry, but life often exists on the margins and interstices of these laws, bending them to their near-breaking limit. The universe seeks equilibriums; it prefers to disperse energy, disrupt organization, and maximize chaos. Life is designed to combat these forces. We slow down reactions, concentrate matter, and organize chemicals into compartments; we sort laundry on Wednesdays. “It sometimes seems as if curbing entropy is our quixotic purpose in the universe,” James Gleick wrote. We live in the loopholes of natural laws, seeking extensions, exceptions, and excuses.

Such was my understanding of the history of art – its ‘narrative’, I ought to call it – until I met my wife. It is barely more sophisticated now, though I’ve picked up a few things along the way, enough to get by, so that my art appreciation is almost on a par with my French. In the early days of our relationship Connie was quite evangelical and bought me several books, second-hand editions because we were in our happy-but-poor phase. Gombrich’s The Story of Art was one, The Shock of the New another, given specifically to stop me tutting at modern art. Well, in the first flush of love, if someone tells you to read something then you damn well read it, and they’re terrific books, both of them, though I’ve retained almost nothing of their contents. Perhaps I should have given Connie a basic primer in organic chemistry in return, but she never expressed an interest.

If we analyse the classes of life, we readily find that there are three cardinal classes which are radically distinct in function. A short analysis will disclose to us that, though minerals have various activities, they are not "living." The plants have a very definite and well known function-the transformation of solar energy into organic chemical energy. They are a class of life which appropriates one kind of energy, converts it into another kind and stores it up; in that sense they are a kind of storage battery for the solar energy; and so I define THE PLANTS AS THE CHEMISTRY-BINDING class of life. The animals use the highly dynamic products of the chemistry-binding class-the plants-as food, and those products-the results of plant-transformation-undergo in animals a further transformation into yet higher forms; and the animals are correspondingly a more dynamic class of life; their energy is kinetic; they have a remarkable freedom and power which the plants do not possess-I mean the freedom and faculty to move about in space; and so I define ANIMALS AS THE SPACE-BINDING CLASS OF LIFE. And now what shall we say of human beings? What is to be our definition of Man? Like the animals, human beings do indeed possess the space-binding capacity but, over and above that, human beings possess a most remarkable capacity which is entirely peculiar to them-I mean the capacity to summarise, digest and appropriate the labors and experiences of the past; I mean the capacity to use the fruits of past labors and experiences as intellectual or spiritual capital for developments in the present; I mean the capacity to employ as instruments of increasing power the accumulated achievements of the all-precious lives of the past generations spent in trial and error, trial and success; I mean the capacity of human beings to conduct their lives in the ever increasing light of inherited wisdom; I mean the capacity in virtue of which man is at once the heritor of the by-gone ages and the trustee of posterity. And because humanity is just this magnificent natural agency by which the past lives in the present and the present for the future, I define HUMANITY, in the universal tongue of mathematics and mechanics, to be the TIME-BINDING CLASS OF LIFE.

I am, reluctantly, a self-confessed carbon chauvinist. Carbon is abundant in the Cosmos. It makes marvelously complex molecules, good for life. I am also a water chauvinist. Water makes an ideal solvent system for organic chemistry to work in and stays liquid over a wide range of temperatures. But sometimes I wonder. Could my fondness for materials have something to do with the fact that I am made chiefly of them? Are we carbon- and water-based because those materials were abundant on the Earth at the time of the origin of life? Could life elsewhere—on Mars, say—be built of different stuff? I am a collection of water, calcium and organic molecules called Carl Sagan. You are a collection of almost identical molecules with a different collective label. But is that all? Is there nothing in here but molecules? Some people find this idea somehow demeaning to human dignity. For myself, I find it elevating that our universe permits the evolution of molecular machines as intricate and subtle as we. But the essence of life is not so much the atoms and simple molecules that make us up as the way in which they are put together. Every now and then we read that the chemicals which constitute the human body cost ninety-seven cents or ten dollars or some such figure; it is a little depressing to find our bodies valued so little. However, these estimates are for human beings reduced to our simplest possible components. We are made mostly of water, which costs almost nothing; the carbon is costed in the form of coal; the calcium in our bones as chalk; the nitrogen in our proteins as air (cheap also); the iron in our blood as rusty nails. If we did not know better, we might be tempted to take all the atoms that make us up, mix them together in a big container and stir. We can do this as much as we want. But in the end all we have is a tedious mixture of atoms. How could we have expected anything else? Harold Morowitz has calculated what it would cost to put together the correct molecular constituents that make up a human being by buying the molecules from chemical supply houses. The answer turns out to be about ten million dollars, which should make us all feel a little better. But even then we could not mix those chemicals together and have a human being emerge from the jar. That is far beyond our capability and will probably be so for a very long period of time. Fortunately, there are other less expensive but still highly reliable methods of making human beings. I think the lifeforms on many worlds will consist, by and large, of the same atoms we have here, perhaps even many of the same basic molecules, such as proteins and nucleic acids—but put together in unfamiliar ways. Perhaps organisms that float in dense planetary atmospheres will be very much like us in their atomic composition, except they might not have bones and therefore not need much calcium. Perhaps elsewhere some solvent other than water is used. Hydrofluoric acid might serve rather well, although there is not a great deal of fluorine in the Cosmos; hydrofluoric acid would do a great deal of damage to the kind of molecules that make us up, but other organic molecules, paraffin waxes, for example, are perfectly stable in its presence. Liquid ammonia would make an even better solvent system, because ammonia is very abundant in the Cosmos. But it is liquid only on worlds much colder than the Earth or Mars. Ammonia is ordinarily a gas on Earth, as water is on Venus. Or perhaps there are living things that do not have a solvent system at all—solid-state life, where there are electrical signals propagating rather than molecules floating about. But these ideas do not

Not one of them [formulae] can be shown to have any existence, so that the formula of one of the simplest of organic bodies is confused by the introduction of unexplained symbols for imaginary differences in the mode of combination of its elements... It would be just as reasonable to describe an oak tree as composed of blocks and chips and shavings to which it may be reduced by the hatchet, as by Dr Kolbe's formula to describe acetic acid as containing the products which may be obtained from it by destructive influences. A Kolbe botanist would say that half the chips are united with some of the blocks by the force parenthesis; the other half joined to this group in a different way, described by a buckle; shavings stuck on to these in a third manner, comma; and finally, a compound of shavings and blocks united together by a fourth force, juxtaposition, is joined to the main body by a fifth force, full stop.

Yes, man is a physical being. But already, on the first page of the Bible, we learn that man can’t be explained as a merely physical being—a collection of cells, tissues, and organs. Human beings transcend the categories of chemistry and biology. Ultimately, man can only be understood in relation to God. This great mystery of creation—that we are created in God’s image—is the key reference point for understanding all aspects of humanity, including our sexuality.

But when it has been shown by the researches of Pasteur that the septic property of the atmosphere depended not on the oxygen, or any gaseous constituent, but on minute organisms suspended in it, which owed their energy to their vitality, it occurred to me that decomposition in the injured part might be avoided without excluding the air, by applying as a dressing some material capable of destroying the life of the floating particles. Upon this principle I have based a practice.

The ability to do hard things is perhaps the most useful ability you can foster in yourself or your children. And proof that you are someone who can do them is one of the most useful assets you can have on your life resume. Our self-image is composed of historical evidence of our abilities. The more hard things you push yourself to do, the more competent you will see yourself to be. If you can run marathons or throw double your body weight over your head, the sleep deprivation from a newborn is only a mild irritant. If you can excel at organic chemistry or econometrics, onboarding for a new finance job will be a breeze. But if we avoid hard things, anything mildly challenging will seem insurmountable. We’ll cry into TikTok over an errant period at the end of a text message. We’ll see ourselves as incapable of learning new skills, taking on new careers, and escaping bad situations. The proof you can do hard things is one of the most powerful gifts you can give yourself.

Pointsman is the only one here maintaining his calm. He appears unruffled and strong. His lab coats have even begun lately to take on a Savile Row serenity, suppressed waist, flaring vents, finer material, rather rakishly notched lapels. In this parched and fallow time, he gushes affluence. After the baying has quieted down at last, he speaks, soothing: “There’s no danger.” “No danger?” screams Aaron Throwster, and the lot of them are off again muttering and growling. “Slothrop’s knocked out Dodson-Truck and the girl in one day!” “The whole thing’s falling apart, Pointsman!” “Since Sir Stephen came back, Fitzmaurice House has dropped out of our scheme, and there’ve been embarrassing inquires down from Duncan Sandys—“ “That’s the P.M.’s son-in-law, Pointsman, not good, not good!” “We’ve already begun to run into a deficit—“ “Funding,” IF you can keep your head, “is available, and will be coming in before long… certainly before we run into any serious trouble. Sir Stephen, far from being ‘knocked out,’ is quite happily at work at Fitzmaurice House, and is At Home there should any of you wish to confirm. Miss Borgesius is still active in the program, and Mr. Duncan Sandys is having all his questions answered. But best of all, we are budgeted well into fiscal ’46 before anything like a deficit begins to rear its head.” “Your Interested Parties again?” sez Rollo Groast. “Ah, I noticed Clive Mossmoon from Imperial Chemicals closeted with you day before yesterday,” Edwin Treacle mentions now. “Clive Mossmoon and I took an organic chemistry course or two together back at Manchester. Is ICI one of our, ah, sponsors, Pointsman?” “No,” smoothly, “Mossmoon, actually, is working out of Malet Street these days. I’m afraid we were up to nothing more sinister than a bit of routine coordination over the Schwarzkommando business.” “The hell you were. I happen to know Clive’s at ICI, managing some sort of polymer research.” They stare at each other. One is lying, or bluffing, or both are, or all of the above. But whatever it is Pointsman has a slight advantage. By facing squarely the extinction of his program, he has gained a great of bit of Wisdom: that if there is a life force operating in Nature, still there is nothing so analogous in a bureaucracy. Nothing so mystical. It all comes down, as it must, to the desires of men. Oh, and women too of course, bless their empty little heads. But survival depends on having strong enough desires—on knowing the System better than the other chap, and how to use it. It’s work, that’s all it is, and there’s no room for any extrahuman anxieties—they only weaken, effeminize the will: a man either indulges them, or fights to win, und so weiter. “I do wish ICI would finance part of this,” Pointsman smiles. “Lame, lame,” mutters the younger Dr. Groast. “What’s it matter?” cries Aaron Throwster. “If the old man gets moody at the wrong time this whole show can prang.” “Brigadier Pudding will not go back on any of his commitments,” Pointsman very steady, calm, “we have made arrangements with him. The details aren’t important.” They never are, in these meetings of his.

The problem of the origin of life is, at bottom, a problem in organic chemistry—the chemistry of carbon compounds—but organic chemistry within an unusual framework. Living things, as we shall see, are specified in detail at the level of atoms and molecules, with incredible delicacy and precision. At the beginning it must have been molecules that evolved to form the first living system. Because life started on earth such a long time ago—perhaps as much as four billion years ago—it is very difficult for us to discover what the first living things were like. All living things on earth, without exception, are based on organic chemistry, and such chemicals are usually not stable over very long periods of time at the range of temperatures which exist on the earth's surface. The constant buffeting of thermal motion over hundreds of millions of years eventually disrupts the strong chemical bonds which hold the atoms of an organic molecule firmly together over shorter periods; over our own lifetime, for example. For this reason it is almost impossible to find "molecular fossils" from these very early times.

As long as museums and universities send out expeditions to bring to light new forms of living and extinct animals and new data illustrating the interrelations of organisms and their environments, as long as anatomists desire a broad comparative basis human for anatomy, as long as even a few students feel a strong curiosity to learn about the course of evolution and relationships of animals, the old problems of taxonomy, phylogeny and evolution will gradually reassert themselves even in competition with brilliant and highly fruitful laboratory studies in cytology, genetics and physiological chemistry.

What was the nature of the universe into which she had been born? Why did it exist at all? If it had a purpose, what was it? These seemed to her the only questions worth exploring. And the only valid technique evolved by humans for exploring such questions was the scientific method, a robust and self-correcting search for the truth. Yet it had become obvious to her since about the age of twelve that science as it had progressed so far – physics, chemistry, biology, all the rest – had only inched towards grappling with the true questions, the fundamentals. Those questions had only been addressed by theologians and philosophers, it seemed to her. Unfortunately, their answers were a mush of doubt, self-delusion and flummery that had probably done more harm than good. And yet that was all there was. For now she had devoted herself, nominally at least, to theology and philosophy, as well as to explorations of the natural sciences, such as on this expedition. She had even received grants to help support this mission to the stepwise East from the Vatican, the Mormons, from Muslim orders, and various philosophical foundations. Dealing with such bodies, she had quickly learned when not to share her view that organized religion was a kind of mass delusion.

The Chemical Society of London was not founded until 1841 and didn’t begin to produce a regular journal until 1848, by which time most learned societies in Britain—Geological, Geographical, Zoological, Horticultural, and Linnaean (for naturalists and botanists)—were at least twenty years old and often much more. The rival Institute of Chemistry didn’t come into being until 1877, a year after the founding of the American Chemical Society. Because chemistry was so slow to get organized, news of Avogadro’s important breakthrough of 1811 didn’t begin to become general until the first international chemistry congress, in Karlsruhe, in 1860.

Gilbert (1540–1603) published his great book on the magnet in 1600. Harvey (1578–1657) discovered the circulation of the blood, and published his discovery in 1628. Leeuwenhoek (1632–1723) discovered spermatozoa, though another man, Stephen Hamm, had discovered them, apparently, a few months earlier; Leeuwenhoek also discovered protozoa or unicellular organisms, and even bacteria. Robert Boyle (1627–91) was, as children were taught when I was young, 'the father of chemistry and son of the Earl of Cork'; he is now chiefly remembered on account of 'Boyle's Law', that in a given quantity of gas at a given temperature, pressure is inversely proportional to volume.

In general, everybody got respectable performances out of peroxide, although there were some difficulties with ignition and with combustion stability, but that freezing point was a tough problem, and most organizations rather lost interest in the oxidizer. Except the Navy. At just that time the admirals were kicking and screaming and refusing their gold-braided lunches at the thought of bringing nitric acid aboard their beloved carriers; they were also digging in their heels with a determined stubbornness that they hadn't shown since that day when it had first been suggested that steam might be preferable to sail for moving a battleship from point A to point B.

First, given what is known about the chemical basis of biology and genetics, what is the likelihood that self-reproducing life forms should have come into existence spontaneously on the early earth, solely through the operation of the laws of physics and chemistry? The second question is about the sources of variation in the evolutionary process that was set in motion once life began: In the available geological time since the first life forms appeared on earth, what is the likelihood that, as a result of physical accident, a sequence of viable genetic mutations should have occurred that was sufficient to permit natural selection to produce the organisms that actually exist?

Atheism will appeal to psychology and sociology to explain human behavior, which is legitimate, but what explains human psychology? Atheism can only find explanatory power in evolution such that the mind is - paradoxically - a mindless organ that is forced to act according to its chemistry and cannot act otherwise. The fact that humans are capable of recognizing depravity in others, are offended by it, seek to reform it, feel guilt, and are capable of redemptive behavior all speak against this explanation. The fact that humans are capable of meta-cognition - thinking about thinking - and are therefore able to postulate their own mindlessness is counter-intuitive to say the least.

Religion invents a problem where none exists by describing the wicked as also made in the image of god and the sexually nonconformist as existing in a state of incurable mortal sin that can incidentally cause floods and earthquakes. How did such evil nonsense ever come to be so influential? And why are we so continually locked in combat with its violent and intolerant votaries? Well, religion was the race’s first (and worst) attempt to make sense of reality. It was the best the species could do at a time when we had no concept of physics, chemistry, biology or medicine. We did not know that we lived on a round planet, let alone that the said planet was in orbit in a minor and obscure solar system, which was also on the edge of an unimaginably vast cosmos that was exploding away from its original source of energy. We did not know that micro-organisms were so powerful and lived in our digestive systems in order to enable us to live, as well as mounting lethal attacks on us as parasites. We did not know of our close kinship with other animals. We believed that sprites, imps, demons, and djinns were hovering in the air about us. We imagined that thunder and lightning were portentous. It has taken us a long time to shrug off this heavy coat of ignorance and fear, and every time we do there are self-interested forces who want to compel us to put it back on again.

It is the form of hemoglobin, then, that permits its function. The physical structure of the molecule enables its chemical nature, the chemical nature enables its physiological function, and its physiology ultimately permits is biological activity. The complex workings of living beings can be perceived in terms of these layers: physics enabling chemistry, and chemistry enabling physiology. To Schrodinger's "What is life?" a biochemist might answer, "If not chemicals." And what are chemicals- a biophysicist might add-if not molecules of matter? This description of physiology-as the exquisite matching of form and function, down to the molecular level-dates back to Aristotle. For Aristotle, living organisms were nothing more than exquisite assemblages of machines.

But here through the dusk comes one who is not glad to be at rest. He is a workman on the ranch, an old man, an immigrant Italian. He takes his hat off to me in all servility, because, forsooth, I am to him a lord of life. I am food to him, and shelter, and existence. He has toiled like a beast all his days, and lived less comfortably than my horses in their deep-strawed stalls. He is labour-crippled. He shambles as he walks. One shoulder is twisted higher than the other. His hands are gnarled claws, repulsive, horrible. As an apparition he is a pretty miserable specimen. His brain is as stupid as his body is ugly. "His brain is so stupid that he does not know he is an apparition," the White Logic chuckles to me. "He is sense-drunk. He is the slave of the dream of life. His brain is filled with superrational sanctions and obsessions. He believes in a transcendent over-world. He has listened to the vagaries of the prophets, who have given to him the sumptuous bubble of Paradise. He feels inarticulate self-affinities, with self-conjured non-realities. He sees penumbral visions of himself titubating fantastically through days and nights of space and stars. Beyond the shadow of any doubt he is convinced that the universe was made for him, and that it is his destiny to live for ever in the immaterial and supersensuous realms he and his kind have builded of the stuff of semblance and deception. "But you, who have opened the books and who share my awful confidence—you know him for what he is, brother to you and the dust, a cosmic joke, a sport of chemistry, a garmented beast that arose out of the ruck of screaming beastliness by virtue and accident of two opposable great toes. He is brother as well to the gorilla and the chimpanzee. He thumps his chest in anger, and roars and quivers with cataleptic ferocity. He knows monstrous, atavistic promptings, and he is composed of all manner of shreds of abysmal and forgotten instincts." "Yet he dreams he is immortal," I argue feebly. "It is vastly wonderful for so stupid a clod to bestride the shoulders of time and ride the eternities." "Pah!" is the retort. "Would you then shut the books and exchange places with this thing that is only an appetite and a desire, a marionette of the belly and the loins?" "To be stupid is to be happy," I contend. "Then your ideal of happiness is a jelly-like organism floating in a tideless, tepid twilight sea, eh?

If you’re a teacher, enjoy your gregarious and participatory students. But don’t forget to cultivate the shy, the gentle, the autonomous, the ones with single-minded enthusiasms for chemistry sets or parrot taxonomy or nineteenth-century art. They are the artists, engineers, and thinkers of tomorrow. If you’re a manager, remember that one third to one half of your workforce is probably introverted, whether they appear that way or not. Think twice about how you design your organization’s office space. Don’t expect introverts to get jazzed up about open office plans or, for that matter, lunchtime birthday parties or team-building retreats. Make the most of introverts’ strengths—these are the people who can help you think deeply, strategize, solve complex problems, and spot canaries in your coal mine.

About 13.5 billion years ago, matter, energy, time and space came into being in what is known as the Big Bang. The story of these fundamental features of our universe is called physics. About 300,000 years after their appearance, matter and energy started to coalesce into complex structures, called atoms, which then combined into molecules. The story of atoms, molecules and their interactions is called chemistry. About 3.8. billion years ago, on a planet called Earth, certain molecules combined to form particularly large and intricate structures called organisms. The story of organisms is called biology. About 70,000 years ago, organisms belonging to the species Homo sapiens started to form even more elaborate structures called cultures. The subsequent development of these human cultures is called history.

This irrelevance of molecular arrangements for macroscopic results has given rise to the tendency to confine physics and chemistry to the study of homogeneous systems as well as homogeneous classes. In statistical mechanics a great deal of labor is in fact spent on showing that homogeneous systems and homogeneous classes are closely related and to a considerable extent interchangeable concepts of theoretical analysis (Gibbs theory). Naturally, this is not an accident. The methods of physics and chemistry are ideally suited for dealing with homogeneous classes with their interchangeable components. But experience shows that the objects of biology are radically inhomogeneous both as systems (structurally) and as classes (generically). Therefore, the method of biology and, consequently, its results will differ widely from the method and results of physical science.

If a society, a city, or a territory, were to guarantee the necessaries of life to its inhabitants (and we shall see how the conception of the necessaries of life can be so extended as to include luxuries), it would be compelled to take possession of what is absolutely needed for production; that is to say — land, machinery, factories, means of transport, etc. Capital in the hands of private owners would be expropriated and returned to the community. The great harm done by bourgeois society, as we have already mentioned, is not only that capitalists seize a large share of the profits of each industrial and commercial enterprise, thus enabling them to live without working, but that all production has taken a wrong direction, as it is not carried on with a view to securing well-being to all. For this reason we condemn it. Moreover, it is impossible to carry on mercantile production in everybody’s interest. To wish it would be to expect the capitalist to go beyond his province and to fulfill duties that he cannot fulfill without ceasing to be what he is — a private manufacturer seeking his own enrichment. Capitalist organization, based on the personal interest of each individual trader, has given all that could be expected of it to society — it has increased the productive force of work. The capitalist, profiting by the revolution effected in industry by steam, by the sudden development of chemistry and machinery, and by other inventions of our century, has endeavoured in his own interest to increase the yield of work, and in a great measure he has succeeded. But to attribute other duties to him would be unreasonable. For example, to expect that he should use this superior yield of work in the interest of society as a whole, would be to ask philanthropy and charity of him, and a capitalist enterprise cannot be based on charity.

Superimposed on the hierarchical framework of defined components of a cell there is another layer. This second layer is highly flexible and can take on an almost infinite variety of forms, like soft and responsive flesh on a bony skeleton. The deep question is whether this higher layer in the construction of cells is itself organized. Are there hierarchies, or at least rules, in the protein-modifying, RNA splicing, gene-regulating processes of a cell? If so, then we have a chance of understanding them. If not, we will never know exactly what a cell will do next. If the detailed chemistry of the cell is simply the outcome of a historical ragbag of ad hoc interactions, then it will be no more predictable than the weather. I do not have an answer to this question. But two features of cells might be relevant. One is a sense of time, or causation - knowledge of the way that things in the real world follow in a certain sequence. The other is integrity, which enables a cell to distinguish between what belongs to itself and what belongs to the outside world.

Timeline of History Years Before the Present 13.5 billion Matter and energy appear. Beginning of physics. Atoms and molecules appear. Beginning of chemistry. 4.5 billion Formation of planet Earth. 3.8 billion Emergence of organisms. Beginning of biology. 6 million Last common grandmother of humans and chimpanzees. 2.5 million Evolution of the genus Homo in Africa. First stone tools. 2 million Humans spread from Africa to Eurasia. Evolution of different human species. 500,000 Neanderthals evolve in Europe and the Middle East. 300,000 Daily usage of fire. 200,000 Homo sapiens evolves in East Africa. 70,000 The Cognitive Revolution. Emergence of fictive language. Beginning of history. Sapiens spread out of Africa. 45,000 Sapiens settle Australia. Extinction of Australian megafauna. 30,000 Extinction of Neanderthals. 16,000 Sapiens settle America. Extinction of American megafauna. 13,000 Extinction of Homo floresiensis. Homo sapiens the only surviving human species. 12,000 The Agricultural Revolution. Domestication of plants and animals. Permanent settlements. 5,000 First kingdoms, script and money. Polytheistic religions. 4,250 First empire – the Akkadian Empire of Sargon. 2,500 Invention of coinage – a universal money. The Persian Empire – a universal political order ‘for the benefit of all humans’. Buddhism in India – a universal truth ‘to liberate all beings from suffering’. 2,000 Han Empire in China. Roman Empire in the Mediterranean. Christianity. 1,400 Islam. 500 The Scientific Revolution. Humankind admits its ignorance and begins to acquire unprecedented power. Europeans begin to conquer America and the oceans. The entire planet becomes a single historical arena. The rise of capitalism. 200 The Industrial Revolution. Family and community are replaced by state and market. Massive extinction of plants and animals. The Present Humans transcend the boundaries of planet Earth. Nuclear weapons threaten the survival of humankind. Organisms are increasingly shaped by intelligent design rather than natural selection. The Future Intelligent design becomes the basic principle of life? Homo sapiens is replaced by superhumans?

However, if we keep living in survival and we are overly sexual, over-consuming, or overstressed by living our lives from the first three centers, we keep drawing from this invisible field of energy carrying information that surrounds the body, and we are consistently turning it into chemistry. The repetition of this process over time causes the field around the body to shrink. (See Figure 4.5.) As a result, we diminish our light and there is no energy that carries a conscious intention moving through these centers to create the correlated mind in each. Essentially, we’ve tapped our own energy field as a resource. That limited level of mind with its limited amount of energy in each center will send a limited signal to the surrounding cells, tissues, organs, and systems of the body. The result can produce a weakened signal and a lower frequency of energy carrying vital information to the body. Therefore, the lowering frequency of the signals creates disease. We could say that from an energetic level, all disease is a lowering of frequency and an incoherent message.

DuPont, for 130 years, had confined itself to making munitions and explosives. In the mid-1920s it then organized its first research efforts in other areas, one of them the brand-new field of polymer chemistry, which the Germans had pioneered during World War I. For several years there were no results at all. Then, in 1928, an assistant left a burner on over the weekend. On Monday morning, Wallace H. Carothers, the chemist in charge, found that the stuff in the kettle had congealed into fibers. It took another ten years before DuPont found out how to make Nylon intentionally. The point of the story is, however, that the same accident had occurred several times in the laboratories of the big German chemical companies with the same results, and much earlier. The Germans were, of course, looking for a polymerized fiber—and they could have had it, along with world leadership in the chemical industry, ten years before DuPont had Nylon. But because they had not planned the experiment, they dismissed its results, poured out the accidentally produced fibers, and started all over again.

Perhaps nowhere is modern chemistry more important than in the development of new drugs to fight disease, ameliorate pain, and enhance the experience of life. Genomics, the identification of genes and their complex interplay in governing the production of proteins, is central to current and future advances in pharmacogenomics, the study of how genetic information modifies an individual's response to drugs and offering the prospect of personalized medicine, where a cocktail of drugs is tailored to an individual's genetic composition. Even more elaborate than genomics is proteomics, the study of an organism's entire complement of proteins, the entities that lie at the workface of life and where most drugs act. Here computational chemistry is in essential alliance with medical chemistry, for if a protein implicated in a disease can be identified, and it is desired to terminate its action, then computer modelling of possible molecules that can invade and block its active site is the first step in rational drug discovery. This too is another route to the efficiencies and effectiveness of personalized medicine.

we have much to learn from the struggles in Alabama and Mississippi in the early 1960s. In the spring of 1963 the Southern Christian Leadership Conference led by Dr. King launched a “fill the jails” campaign to desegregate downtown department stores and schools in Birmingham. But few local blacks were coming forward. Black adults were afraid of losing their jobs, local black preachers were reluctant to accept the leadership of an “Outsider,” and city police commissioner Bull Connor had everyone intimidated. Facing a major defeat, King was persuaded by his aide, James Bevel, to allow any child old enough to belong to a church to march. So on D-day, May 2, before the eyes of the whole nation, thousands of schoolchildren, many of them first graders, joined the movement and were beaten, fire-hosed, attacked by police dogs, and herded off to jail in paddy wagons and school buses. The result was what has been called the “Children’s Miracle.” Inspired and shamed into action, thousands of adults rushed to join the movement. All over the country rallies were called to express outrage against Bull Connor’s brutality. Locally, the power structure was forced to desegregate lunch counters and dressing rooms in downtown stores, hire blacks to work downtown, and begin desegregating the schools. Nationally, the Kennedy administration, which had been trying not to alienate white Dixiecrat voters, was forced to begin drafting civil rights legislation as the only way to forestall more Birminghams. The next year as part of Mississippi Freedom Summer, activists created Freedom Schools because the existing school system (like ours today) had been organized to produce subjects, not citizens. People in the community, both children and adults, needed to be empowered to exercise their civil and voting rights. A mental revolution was needed. To bring it about, reading, writing, and speaking skills were taught through discussions of black history, the power structure, and building a movement. Everyone took this revolutionary civics course, then chose from more academic subjects such as algebra and chemistry. All over Mississippi, in church basements and parish halls, on shady lawns and in abandoned buildings, volunteer teachers empowered thousands of children and adults through this community curriculum. The Freedom Schools of 1964 demonstrated that when Education involves young people in making community changes that matter to them, when it gives meaning to their lives in the present instead of preparing them only to make a living in the future, young people begin to believe in themselves and to dream of the future.

Ocean Acidification is sometimes referred to as Global Warming's Equally Evil Twin. The irony is intentional and fair enough as far as it goes... No single mechanism explains all the mass extinctions in the record and yet changes in ocean chemistry seem to be a pretty good predictor. Ocean Acidification played a role in at least 2 of the Big Five Extinctions: the End-Permian and the End-Triassic. And quite possibly it was a major factor in a third, the End-Cretaceous. ...Why is ocean acidification so dangerous? The question is tough to answer only because the list of reasons is so long. Depending on how tightly organisms are able to regulate their internal chemistry, acidification may affect such basic processes as metabolism, enzyme activity, and protein function. Because it will change the makeup of microbial communities, it will alter the availability of key nutrients, like iron and nitrogen. For similar reasons, it will change the amount of light that passes through the water, and for somewhat different reasons, it will alter the way sound propagates. (In general, acidification is expected to make the seas noisier.) It seems likely to promote the growth of toxic algae. It will impact photosynthesis—many plant species are apt to benefit from elevated CO2 levels—and it will alter the compounds formed by dissolved metals, in some cases in ways that could be poisonous. Of the myriad possible impacts, probably the most significant involves the group of creatures known as calcifiers. (The term calcifier applies to any organism that builds a shell or external skeleton or, in the case of plants, a kind of internal scaffolding out of the mineral calcium carbonate.)... Ocean acidification increases the cost of calcification by reducing the number of carbonate ions available to organisms that build shells or exoskeletons. Imagine trying to build a house while someone keeps stealing your bricks. The more acidified the water, the greater the energy that’s required to complete the necessary steps. At a certain point, the water becomes positively corrosive, and solid calcium carbonate begins to dissolve. This is why the limpets that wander too close to the vents at Castello Aragonese end up with holes in their shells. According to geologists who work in the area, the vents have been spewing carbon dioxide for at least several hundred years, maybe longer. Any mussel or barnacle or keel worm that can adapt to lower pH in a time frame of centuries presumably already would have done so. “You give them generations on generations to survive in these conditions, and yet they’re not there,” Hall-Spencer observed.

Lovelock comments in response . . . We [as scientists] had become so used to thinking in terms of cause and effect that we no longer seemed to realize that the whole could be more than the sum of its parts. . . . The Earth self regulates its climate and chemistry so as to keep itself habitable and it is this that is the sticking point for many, if not most, scientists. Such a conclusion could never have come from reductionist thinking, and that is why arguments with biologists and others over Gaia have been so acrimonious for so long. The fact that reductionist science cannot offer a rational explanation for quantum phenomena like entanglement, nor of whole systems phenomena such as emergence, does not mean that these phenomena do not exist. Their existence confirms the limits of the Cartesian view of the universe. . . . Eminent representatives of the Earth and Life sciences secure in their disciplines ignored the fact that organisms massively alter their environment as well as adapting to it, and they did not see the evolution of the organisms and the evolution of their environment as a single coupled process. . . . I know it is unrealistic to expect them to welcome a theory like Gaia, which not only asks them to join together as if married but also to take a vow to believe in the phenomena of emergence.

My own observations had by now convinced me that the mind of the average Westerner held an utterly distorted image of Islam. What I saw in the pages of the Koran was not a ‘crudely materialistic’ world-view but, on the contrary, an intense God-consciousness that expressed itself in a rational acceptance of all God-created nature: a harmonious side-by-side of intellect and sensual urge, spiritual need and social demand. It was obvious to me that the decline of the Muslims was not due to any shortcomings in Islam but rather to their own failure to live up to it. For, indeed, it was Islam that had carried the early Muslims to tremendous cultural heights by directing all their energies toward conscious thought as the only means to understanding the nature of God’s creation and, thus, of His will. No demand had been made of them to believe in dogmas difficult or even impossible of intellectual comprehension; in fact, no dogma whatsoever was to be found in the Prophet’s message: and, thus, the thirst after knowledge which distinguished early Muslim history had not been forced, as elsewhere in the world, to assert itself in a painful struggle against the traditional faith. On the contrary, it had stemmed exclusively from that faith. The Arabian Prophet had declared that ‘Striving after knowledge is a most sacred duty for every Muslim man and woman’: and his followers were led to understand that only by acquiring knowledge could they fully worship the Lord. When they pondered the Prophet’s saying, ‘God creates no disease without creating a cure for it as well’, they realised that by searching for unknown cures they would contribute to a fulfilment of God’s will on earth: and so medical research became invested with the holiness of a religious duty. They read the Koran verse, ‘We create every living thing out of water’ - and in their endeavour to penetrate to the meaning of these words, they began to study living organisms and the laws of their development: and thus they established the science of biology. The Koran pointed to the harmony of the stars and their movements as witnesses of their Creator’s glory: and thereupon the sciences of astronomy and mathematics were taken up by the Muslims with a fervour which in other religions was reserved for prayer alone. The Copernican system, which established the earth’s rotation around its axis and the revolution of the planet’s around the sun, was evolved in Europe at the beginning of the sixteenth century (only to be met by the fury of the ecclesiastics, who read in it a contradiction of the literal teachings of the Bible): but the foundations of this system had actually been laid six hundred years earlier, in Muslim countries - for already in the ninth and tenth centuries Muslim astronomers had reached the conclusion that the earth was globular and that it rotated around its axis, and had made accurate calculations of latitudes and longitudes; and many of them maintained - without ever being accused of hearsay - that the earth rotated around the sun. And in the same way they took to chemistry and physics and physiology, and to all the other sciences in which the Muslim genius was to find its most lasting monument. In building that monument they did no more than follow the admonition of their Prophet that ‘If anybody proceeds on his way in search of knowledge, God will make easy for him the way to Paradise’; that ‘The scientist walks in the path of God’; that ‘The superiority of the learned man over the mere pious is like the superiority of the moon when it is full over all other stars’; and that ‘The ink of the scholars is more precious that the blood of martyrs’. Throughout the whole creative period of Muslim history - that is to say, during the first five centuries after the Prophet’s time - science and learning had no greater champion than Muslim civilisation and no home more secure than the lands in which Islam was supreme.

Physics becomes chemistry, chemistry becomes biology, biology becomes psychology, and so on. Or, put another way: cells emerge from the interactions of atoms, organs emerge from the interactions of cells, and societies emerge from the interactions of people. Each level of emergence produces higher order functionalities.

And then the colossal success of modern natural science and the associated technology can lead us to feel that it unlocks all mysteries, that it will ultimately explain everything, that human science must be developed on the same basic plan, or even ultimately reduced to physics, or at least organic chemistry. And

Any of the components of an organism-say, a haemoglobin molecule-can be given an arbitrarily complete and precise description in the language of atomic physics or chemistry, and yet this description will miss something that is nevertheless materially relevant to its structure and its very existence. Specifically, it will provide no hint of why this highly improbable molecular configuration is so prevalent, as compared with the astronomical number of molecular forms that are not present. Haemoglobin,

these are the topics that MCAT 2015 will no longer test: General Chemistry Phase equilibria removed Exception: phase diagrams still tested Organic Chemistry Several compounds no longer directly tested Simple organic compounds (alkanes, alkenes, alkynes); Exception: nucleophilic substitution reactions still tested Aromatic compounds Ethers Amines Physics Momentum removed Solids (density, elastic properties, and so on) removed Periodic motion (springs & pendulums) removed Exception: Spring potential energy still tested

Nor can one underestimate the lengths to which the Catholic hierarchy went to keep its ugly secrets to itself. One lay Catholic described it as follows: “Their structure and social chemistry is almost identical to the Mafia. There is a deep secrecy and a fierce loyalty to the organization.

But this story isn’t about Toby’s twelfth birthday, or the car wreck at Jonas’s party—not really. There is a type of problem in organic chemistry called a retrosynthesis. You are presented with a compound that does not occur in nature, and your job is to work backward, step by step, and ascertain how it came to exist—what sort of conditions led to its eventual creation. When you are finished, if done correctly, the equation can be read normally, making it impossible to distinguish the question from the answer. I still think that everyone’s life, no matter how unremarkable, has a singular tragic encounter after which everything that really matters will happen. That moment is the catalyst—the first step in the equation. But knowing the first step will get you nowhere—it’s what comes after that determines the result.

Today chemists can artificially make hundreds of thousands of organic compounds, most of which are not duplicated in nature.

AS I TELL MY PATIENTS, your skin, hair, and nails are repairable and replaceable, and most of your organs can be revitalized. But the brain is the one organ you can’t replace (no matter what you’ve seen in horror movies). The brain is where your life resides. It governs all aspects of your health as well as your emotional state. And while you can’t get a new brain, you can improve the one you have. There are many different ways to literally make your brain younger which can enhance every facet of your health. This chapter will show how you can lose weight permanently once you balance your brain. Without taking the brain into account, you can diet for the rest of your life and never be happy with the results.

Your organization’s culture is the product of the people in it, and every addition and subtraction will alter the chemistry. Do everything you can to keep it harmonious.

Nomenclature is one of the most important prerequisites for answering organic chemistry questions on Test Day; if you don’t know which chemical compound the question is asking about, it’s hard to get the answer right! That’s

Subspecialty : Botany Studies : plants Subspecialty : Zoology Studies : animals Subspecialty : Marine biology Studies : organisms living in and around oceans, and seas Subspecialty : Fresh water biology Studies : organisms living in and around freshwater lakes, streams, rivers, ponds, etc. Subspecialty : Microbiology Studies : microorganisms Subspecialty : Bacteriology Studies : bacteria Subspecialty : Virology Studies : viruses ( see Figure below ) Subspecialty : Entomology Studies : insects Subspecialty : Taxonomy Studies : the classification of organisms Subspecialty : Studies : Life Science : Cell biology What it Examines : cells and their structures (see Figure below ) Life Science : Anatomy What it Examines : the structures of animals Life Science : Morphology What it Examines : the form and structure of living organisms Life Science : Physiology What it Examines : the physical and chemical functions of tissues and organs Life Science : Immunology What it Examines : the mechanisms inside organisms that protect them from disease and infection Life Science : Neuroscience What it Examines : the nervous system Life Science : Developmental biology and embryology What it Examines : the growth and development of plants and animals Life Science : Genetics What it Examines : the genetic make up of all living organisms (heredity) Life Science : Biochemistry What it Examines : the chemistry of living organisms Life Science : Molecular biology What it Examines : biology at the molecular level Life Science : Epidemiology What it Examines : how diseases arise and spread Life Science : What it Examines : Life Science : Ecology What it Examines : how various organisms interact with their environments Life Science : Biogeography What it Examines : the distribution of living organisms (see Figure below ) Life Science : Population biology What it Examines : the biodiversity, evolution, and environmental biology of populations of organisms Life Science : What it Examines :

The iron group are the only metals that fall from the sky.

Bog iron ore is limonite or goethite, deposited with the aid of iron bacteria in anaerobic swamps. The iron is carried in by waters containing CO2 as soluble bicarbonates. The organic matter reduces it to oxides, which make characteristic iridescent patches on the water, then precipitate on the bottom of the marsh to form an iron-rich layer. It was smelted at Lynn, Massachusetts with oyster shells and charcoal to be hammered into bars to be traded for slaves in Africa, which were sold in the Caribbean for sugar to be brought to New England for fermentation and distillation into rum to be sold to the Indians, making the fortunes of Boston and Providence. The Lynn ironworks have been reconstructed, but with questionable fidelity.

Eye contact should never be forced but should come organically as our children learn to trust us. With eye contact comes deeper trust and connection. Working on this simple yet important skill improves brain chemistry, regulation, and most importantly, your relationship with your child.

Because it was the fate of the damned to run of course, not jog, run, their piss on fire and their shit molten, boiling sperm and their ovaries frying; what they were permitted of body sprinting at full throttle, wounded gallop, burning not fat—fat sizzled off in the first seconds, bubbled like bacon and disappeared, evaporate as steam, though the weight was still there, still with you, its frictive drag subversive as a tear in a kite and not even muscle, which blazed like wick, but the organs themselves, the liver scorching and the heart and brains at flash point, combusting the chemistries, the irons and phosphates, the atoms and elements, conflagrating vitamin, essence, soul, yet somehow everything still within the limits if not of endurance then of existence. Damnation strictly physical, nothing personal, Hell’s lawless marathon removed from character. ‘Sure,’ someone had said, ‘we hit the Wall with every step. It’s all Wall down here. It’s wall-to-wall Wall. What, did you think Hell would be like some old-time baker’s oven? That all you had to do was lie down on a pan like dough, the insignificant heat bringing you out, fluffing you up like bread or oatmeal cookies? You think we’re birthday cake? We’re fucking stars. Damnation is hard work, eternity lousy hours.

Ek-sistence can be said only of the essence of the human being, that is, only of the human way "to be." For as far as our experience shows, only the human being is admitted to the destiny of ek-sistence. Therefore ek-sistence can also never be thought of as a specific kind of living creature among others - granted that the human being is destined to think the essence of his being and not merely to give accounts of the nature and history of his constitution and activities. Thus even what we attribute to the human being as aniditar on the basis of the comparison with "beastsn is itself grounded in the essence of ek-sistence. The human body is something essentially 11561 other than an animal organism. Nor is the error of biologism overcome by adjoining a soul to the human body, a mind to the soul. and the existentiell to the mind, and then louder than before singing the praises of the mind - only to let everything relapse into "life-experience," with a warning that thinking by its inflexible concepts disrupts the flow of life and that thought of being distorts existence. The fact that physiology and physiological chemistry can scientifically investigate the human being as an organism is no proof that in this "organicn thing, that is, in the body scientifically explained, the essence of the human being consists. That has as little validity as the notion that the essence of nature has been discovered in atomic energy. It could even be that nature, in the face it turns toward the human being's technical mastery, is simply concealing in essence. Just as little as the essence of the human being consists in being an animal organism can this insufficient definition of the essence of the human being be overcome or offset by outfimng the human being with an immortal soul, the power of reason, or the character of a person. In each instance its essence is passed over, and passed over on the basis of the same metaphysical projection.

In 1928, within weeks of moving to DuPont, Carothers decided to prove his theory about the bonding in giant molecules by building one. One of the best-known reactions in organic chemistry involves creating compounds called esters by joining together certain acids and alcohols. Carothers hypothesized that molecules that had acid functions on both ends could be reacted with molecules that had alcohol groupings on both ends in order to form long chains. He was right: Carothers had invented polyesters