Onto The Next Chapter Quotes

While dragging herself up she had to hang onto the rail. Her twisted progress was that of a cripple. Once on the open deck she felt the solid impact of the black night, and the mobility of the accidental home she was about to leave. Although Lucette had never died before—no, dived before, Violet—from such a height, in such a disorder of shadows and snaking reflections, she went with hardly a splash through the wave that humped to welcome her. That perfect end was spoiled by her instinctively surfacing in an immediate sweep — instead of surrendering under water to her drugged lassitude as she had planned to do on her last night ashore if it ever did come to this. The silly girl had not rehearsed the technique of suicide as, say, free-fall parachutists do every day in the element of another chapter. Owing to the tumultuous swell and her not being sure which way to peer through the spray and the darkness and her own tentaclinging hair—t,a,c,l—she could not make out the lights of the liner, an easily imagined many-eyed bulk mightily receding in heartless triumph. Now I’ve lost my next note. Got it. The sky was also heartless and dark, and her body, her head,and particularly those damned thirsty trousers, felt clogged with Oceanus Nox, n,o,x. At every slap and splash of cold wild salt, she heaved with anise-flavored nausea and there was an increasing number, okay, or numbness, in her neck and arms. As she began losing track of herself, she thought it proper to inform a series of receding Lucettes—telling them to pass it on and on in a trick-crystal regression—that what death amounted to was only a more complete assortment of the infinite fractions of solitude. She did not see her whole life flash before her as we all were afraid she might have done; the red rubber of a favorite doll remained safely decomposed among the myosotes of an un-analyzable brook; but she did see a few odds and ends as she swam like a dilettante Tobakoff in a circle of brief panic and merciful torpor. She saw a pair of new vairfurred bedroom slippers, which Brigitte had forgotten to pack; she saw Van wiping his mouth before answering, and then, still withholding the answer, throwing his napkin on the table as they both got up; and she saw a girl with long black hair quickly bend in passing to clap her hands over a dackel in a half-tom wreath. A brilliantly illumined motorboat was launched from the not-too-distant ship with Van and the swimming coach and the oilskin-hooded Toby among the would-be saviors; but by that time a lot of sea had rolled by and Lucette was too tired to wait. Then the night was filled with the rattle of an old but still strong helicopter. Its diligent beam could spot only the dark head of Van, who, having been propelled out of the boat when it shied from its own sudden shadow, kept bobbing and bawling the drowned girl’s name in the black, foam-veined, complicated waters.

Baby girl, this is your mother. I know I’ve given you explicit instructions to trace this into your yearbook, but they’re my words. That means this is from me, my heart, and my love for you. There’s so many things I want to say to you, things I want you to hear, to know, but let’s start with the reason I’m having you put these words in your senior yearbook. First of all, this book is everything. It may be pictures, some names of people you won’t remember in five years, ten years, or longer, but this book is more important than you can imagine. It’s the first book that’s the culmination of your first chapter in life. You will have many. So many! But this book is the physical manifestation of your first part in life. Keep it. Treasure it. Whether you enjoyed school or not, it’s done. It’s in your past. These were the times you were a part of society from a child to who you are now, a young adult woman. When you leave for college, you’re continuing your education, but you’re moving onto your next chapter in life. The beginning of adulthood. This yearbook is your bridge. Keep this as a memento forever. It sums up who you grew up with. It houses images of the buildings where your mind first began to learn things, where you first began to dream, to set goals, to yearn for the road ahead. It’s so bittersweet, but those memories were your foundation to set you up for who you will become in the future. Whether they brought pain or happiness, it’s important not to forget. From here, you will go on and you will learn the growing pains of becoming an adult. You will refine your dreams. You will set new limits. Change your mind. You will hurt. You will laugh. You will cry, but the most important is that you will grow. Always, always grow, honey. Challenge yourself. Put yourself in uncomfortable situations (BUT BE SAFE!) and push yourself not to think about yourself, your friends, your family, but to think about the world. Think about others. Understand others, and if you can’t understand, then learn more about them. It’s so very important. Once you have the key to understanding why someone else hurts or dreams or survives, then you have ultimate knowledge. You have empathy. Oh, honey. As I’m writing this, I can see you on the couch reading a book. You are so very beautiful, but you are so very humble. You don’t see your beauty, and I want you to see your beauty. Not just physical, but your inner kindness and soul. It’s blinding to me. That’s how truly stunning you are. Never let anyone dim your light. Here are some words I want you to know as you go through the rest of your life: Live. Learn. Love. Laugh. And, honey, know. Just know that I am with you always.

Taking control of the situation There are a great many parents—as I’ve learned by attending endless parent support group meetings— who had the same high hopes for their families as I. If you’re such a parent, then you probably know that it isn’t just the child who can be out of control, but also the parent. Possibly you are also aware that continuous reacting on your part is useless as well as extremely hazardous to your health and well-being. The most ruinous thing you can do is to allow the situation to continue on its present destructive course. Here are some simple steps you can take to deactivate the negativity so rampant in your family dynamics. Please note that it takes courage and determination to carry this off successfully. Cut off all funds to the addict. Holding onto the purse strings with an iron fist will have immediate results, as well as repercussions. (Keep an eye on family valuables. In fact, lock them away.) Cut off all privileges accorded to your addicts— such as use of the family car or having their friends in your house. Carry out all threats you make. The fastest way to lose credibility with addicted children is to become a “softie” at the last minute. Refuse to rescue your addicts when they get into legal jams. Don’t pay their fines or their bail. Get yourself into a support group such as Al-Anon, Nar-Anon, Parents Anonymous, or Tough Love as fast as you can. Attempt to get your addicted kids into rehabs. If they’re underage you can sign them in. Adult admission is done on a voluntary basis, so you may be out of luck. Drugs erase any trace of conscience. Be aware that many of today’s drugged youths will think nothing of injuring or even murdering their parents for money. If you suspect that your child could resort to this level of violence, get in touch with the police. If you’re a single parent there will be one voice, but if you’re married there’ll be two. It’s important to merge those two voices so that a single, clear message reaches the addict. If you can work with your partner as a team to institute these simple steps when dealing with the addict, you’ll have done yourself and your family a great service. If, however, you entertain the notion that you were responsible for your child’s addictions in the first place, chances are you won’t be effective in enforcing these guidelines. That’s what the next chapter is all about. Note 1. Drug abuse and alcoholism are officially listed in The International Classification of Diseases, 4th edition, 9th revision, the World Health Organization’s directory on diseases.

Accountability An executive in service, as I said in the first chapter, must be one who lives for today but cares nothing for tomorrow. If this is so, and he does what he has to do day-to-day, with zeal and thoroughness, so that nothing at all is left undone, he has no reason to feel any reproach or regret. But living in the moment of the day does not mean ignoring future consequences. Troubles arise when people rely on the future and become lazy and indolent and let things slide. They put off quite urgent affairs after a lot of discussion, not to speak of less important ones, in the belief that they will do just as well the next day. They push off this responsibility onto one comrade and blame another for shortcomings. And when trying to get someone to do something for them, if there is no one to assist, they leave it undone, so that before long there is a big accumulation of unfinished jobs. This is a mistake that comes from relying on the future against which one must be very definitely on one’s guard. For instance, some executives are never accountable enough to arrive on time for a meeting. These silly fellows waste time by having a smoke or chatting with their secretaries and colleagues when they ought to be starting, and so leave their office late. They then have to hurry so much that, as they walk or drive, they do not acknowledge with courtesy people they pass. And when they do get to their destination, they are all covered with perspiration and breathing heavily, and then have to make some plausible excuse for their lateness on account of some very urgent business they had to do. When an executive has a meeting, he never ought to be late for any private reason. And if one man takes care to be a little early and then has to wait a bit for a comrade who is late, he should not sit down and yawn, neither should he hurry away when his time is up as though reluctant to be there. For these things do not look at all well either.

As strange as it sounds, it is no longer possible to determine how many human genomes have been sequenced. At present the strategy of choice is whole-genome re-sequencing (Chapter 3) whereby next-generation sequence data are mapped onto a reference genome. The results have been breathtaking. The recently concluded (and aptly named) 1000 Genomes Project Consortium catalogued ~85 million SNPs, 3.6 million short insertions/deletions, and 60,000 larger structural variants in a global sampling of human genetic diversity. These data are catalysing research in expected and unexpected ways. Beyond providing a rich source of data for GWA-type studies focused on disease, scientists are also using the 1000 Genomes Project data to learn about our basic biology, something that proved surprisingly difficult when only a pair of genomes was available. For example, a recent GWAS taking advantage of the 1000 Genomes Project data identified ten genes associated with kidney development and function, genes that had previously not been linked to this critical aspect of human physiology. In 2016, Craig Venter’s team reported the sequencing of 10,545 human genomes. Beyond the impressively low cost (US$1,000–2,000 per genome) and high quality (30–40× coverage), the study was significant in hinting at the depths of human genome diversity yet to be discovered. More than 150 million genetic variants were identified in both coding and non-coding regions of the genome; each sequenced genome had on average ~8,600 novel variants. Furthermore, each new genome was found to contain 0.7 Mbp of sequence that is not contained in the reference genome. This underscores the need for methods development in the area of structure variation detection in personal genome data. Overall, however, the authors concluded that ‘the data generated by deep genome sequencing is of the quality necessary for clinical use’.

I’m just happy because I like it when you call me Joshua,” he said, smiling. His fingers brushed the hair at the top of my forehead and he kissed me gently. There was something so intimate in the way he was with me I had to change the subject. “What’s this, Joshua?” I asked, looking away from him, picking up a dog-eared copy of Under a Flaming Sky from the upside-down box he used as a nightstand. I flopped onto my back. “I didn’t know you like to read.” He scooted down to lie next to me and propped himself on his elbow. “I like to read about fires.” I held the book over my face. “Is it any good? What’s it about?” I smiled at him. “Will you read me a chapter?” He took the book from me and leaned over the other side of the bed. “It’s about a firestorm in Minnesota, back in 1894.” When he came back up, he was wearing glasses. I blinked at him as he flipped to the dog-eared page, scooting to sit up against his pillows. “Shut the fuck up,” I said, staring at him. He looked over at me. “What?” “You wear glasses?” “Just for reading. Why?” Just when I thought the man couldn’t get any more attractive, he goes and puts on motherfucking glasses. “This is a joke, right? You are not allowed to get hotter than you already are. I forbid it.” He set the book down across his lap and grinned at me. “You like the glasses, huh?” He bounced his eyebrows. “Want me to keep them on the next time?” I giggled. “Yes, please.” He pulled the glasses down and then put them back on. His eyes got wide. “Oh, wow. Look how pretty you are!” I laughed and moved his book, climbing over his lap until I straddled him. His sweatshirt rode up my thighs. Then I held his cheeks in my hands and peppered kisses all over his face. He closed his eyes and let me, beaming like a happy little kid.

Maybe we were still on the same page - we'd just moved onto the next chapter.

going to happen when I get you back here tonight. I want you to think about how, first, I’m going to get you out of that dress, then, second, I’m going to fuck you thoroughly and ruthlessly.” My lips part, my body feeling as if thick, warm cream has just been poured all over the outside and inside of me. It pools between my legs, bubbling. With an arrogant grin, Travis leaves me alone, and I fall back onto the luxurious bed. In case I had any delusions about scoring a victory today, Travis has just let me know that he’ll always be in charge. Chapter 21 Travis doesn’t allow me to forget my place the next few days, but there’s something new between us now. Something that started in Times Square and