Molecular Biology Quotes

These days vampires gravitated toward particle accelerators, projects to decode the genome, and molecular biology. Once they had flocked to alchemy, anatomy, and electricity. If it went bang, involved blood, or promised to unlock the secrets of the universe, there was sure to be a vampire around.

Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.

A curious aspect of the theory of evolution is that everybody thinks he understands it.

It is remarkable that mind enters into our awareness of nature on two separate levels. At the highest level, the level of human consciousness, our minds are somehow directly aware of the complicated flow of electrical and chemical patterns in our brains. At the lowest level, the level of single atoms and electrons, the mind of an observer is again involved in the description of events. Between lies the level of molecular biology, where mechanical models are adequate and mind appears to be irrelevant. But I, as a physicist, cannot help suspecting that there is a logical connection between the two ways in which mind appears in my universe. I cannot help thinking that our awareness of our own brains has something to do with the process which we call "observation" in atomic physics. That is to say, I think our consciousness is not just a passive epiphenomenon carried along by the chemical events in our brains, but is an active agent forcing the molecular complexes to make choices between one quantum state and another. In other words, mind is already inherent in every electron, and the processes of human consciousness differ only in degree but not in kind from the processes of choice between quantum states which we call "chance" when they are made by electrons.

Today, the theory of evolution is an accepted fact for everyone but a fundamentalist minority, whose objections are based not on reasoning but on doctrinaire adherence to religious principles.

When I started reading the literature of molecular biology, I was stunned by certain descriptions. Admittedly, I was on the lookout for anything unusual, as my investigation had led me to consider that DNA and its cellular machinery truly were an extremely sophisticated technology of cosmic origin. But as I pored over thousands of pages of biological texts, I discovered a world of science fiction that seemed to confirm my hypothesis. Proteins and enzymes were described as 'miniature robots,' ribosomes were 'molecular computers,' cells were 'factories,' DNA itself was a 'text,' a 'program,' a 'language,' or 'data.' One only had to do a literal reading of contemporary biology to reach shattering conclusions; yet most authors display a total lack of astonishment and seem to consider that life is merely 'a normal physiochemical phenomenon.

What is truly revolutionary about molecular biology in the post-Watson-Crick era is that it has become digital...the machine code of the genes is uncannily computer-like.' -Richard Dawkins

Shamanism resembles an academic discipline (such as anthropology or molecular biology); with its practitioners, fundamental researchers, specialists, and schools of thought it is a way of apprehending the world that evolves constantly. One thing is certain: Both indigenous and mestizo shamans consider people like the Shipibo-Conibo, the Tukano, the Kamsá, and the Huitoto as the equivalents to universities such as Oxford, Cambridge, Harvard, and the Sorbonne; they are the highest reference in matters of knowledge. In this sense, ayahuasca-based shamanism is an essentially indigenous phenomenon. It belongs to the indigenous people of Western Amizonia, who hold the keys to a way of knowing that they have practiced without interruption for at least five thousand years. In comparison, the universities of the Western world are less than nine hundred years old.

It is my belief that the basic knowledge that we're providing to the world will have a profound impact on the human condition and the treatments for disease and our view of our place on the biological continuum.

As Heinz Pagels has said, The challenge to our civilization which has come from our knowledge of the cosmic energies that fuels the stars, the movement of light and electrons through matter, the intricate molecular order which is the biological basis of life, must be met by the creation of a moral and political order which will accommodate these forces or we shall be destroyed. It will try our deepest resources of reason and compassion.

To grasp the reality of life as it has been revealed by molecular biology, we must magnify a cell a thousand million times until it is twenty kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would then see would be an object of unparalleled complexity and adaptive design. On the surface of the cell we would see millions of openings, like the port holes of a vast space ship, opening and closing to allow a continual stream of materials to flow in and out. If we were to enter one of these openings we would find ourselves in a world of supreme technology and bewildering complexity.

For all the accomplishments of molecular biology, we still can't tell a live cat from a dead cat.

Here, the results of recent molecular biological studies are illuminating in linking germs to the rise of food production, in Eurasia much more than in the Americas.

If it's true there's a beginning to the universe, as modern cosmologists now agree, then this implies a cause that transcends the universe. If the laws of physics are fine-tuned to permit life, as contemporary physicists are discovering, then perhaps there's a designer who fine-tuned them. If there's information in the cell, as molecular biology shows, then this suggests intelligent design. To get life going in the first place would have required biological information; the implications point beyond the material realm to a prior intelligent cause. -Stephen C Meyer, PHD

Look at any randomly selected piece of your world. Encoded deep in the biology of every cell in every blade of grass, in every insect’s wing, in every bacterium cell, is the history of the third planet from the Sun in a Solar System making its way lethargically around a galaxy called the Milky Way. Its shape, form, function, colour, smell, taste, molecular structure, arrangement of atoms, sequence of bases, and possibilities for the future are all absolutely unique. There is nowhere else in the observable Universe where you will see precisely that little clump of emergent, living complexity. It is wonderful.

I think that the formation of [DNA's] structure by Watson and Crick may turn out to be the greatest developments in the field of molecular genetics in recent years.

Every disease that’s with us is caused by DNA. And every disease can be fixed by DNA.

This overall flow of genetic information—from DNA to RNA to protein—is known as the central dogma of molecular biology, and it is the language used to communicate and express life.

The commercialization of molecular biology is the most stunning ethical event in the history of science, and it has happened with astonishing speed. For four hundred years since Galileo, science has always proceeded as a free and open inquiry into the workings of nature. Scientists have always ignored national boundaries, holding themselves above the transitory concerns of politics and even wars. Scientists have always rebelled against secrecy in research, and have even frowned on the idea of patenting their discoveries, seeing themselves as working to the benefit of all mankind. And for many generations, the discoveries of scientists did indeed have a peculiarly selfless quality... Suddenly it seemed as if everyone wanted to become rich. New companies were announced almost weekly, and scientists flocked to exploit genetic research... It is necessary to emphasize how significant this shift in attitude actually was. In the past, pure scientists took a snobbish view of business. They saw the pursuit of money as intellectually uninteresting, suited only to shopkeepers. And to do research for industry, even at the prestigious Bell or IBM labs, was only for those who couldn't get a university appointment. Thus the attitude of pure scientists was fundamentally critical toward the work of applied scientists, and to industry in general. Their long-standing antagonism kept university scientists free of contaminating industry ties, and whenever debate arose about technological matters, disinterested scientists were available to discuss the issues at the highest levels. But that is no longer true. There are very few molecular biologists and very few research institutions without commercial affiliations. The old days are gone. Genetic research continues, at a more furious pace than ever. But it is done in secret, and in haste, and for profit.

Whatever the nature of organizing relations may be,' J. Needham wrote in 1932, 'they form the central problem of biology, and biology will be fruitful in the future only if this is recognized. The hierarchy of relations, from the molecular structure of carbon compounds to the equilibrium of species and ecological wholes, will perhaps be the leading idea of the future.

I’m not sure, though, what “for later” means anymore. Something changed in the world. Not too long ago, it changed, and we know it. We don’t know how to explain it yet, but I think we all can feel it, somewhere deep in our gut or in our brain circuits. We feel time differently. No one has quite been able to capture what is happening or say why. Perhaps it’s just that we sense an absence of future, because the present has become too overwhelming, so the future has become unimaginable. And without future, time feels like only an accumulation. An accumulation of months, days, natural disasters, television series, terrorist attacks, divorces, mass migrations, birthdays, photographs, sunrises. We haven’t understood the exact way we are now experiencing time. And maybe the boy’s frustration at not knowing what to take a picture of, or how to frame and focus the things he sees as we all sit inside the car, driving across this strange, beautiful, dark country, is simply a sign of how our ways of documenting the world have fallen short. Perhaps if we found a new way to document it, we might begin to understand this new way we experience space and time. Novels and movies don’t quite capture it; journalism doesn’t; photography, dance, painting, and theater don’t; molecular biology and quantum physics certainly don’t either. We haven’t understood how space and time exist now, how we really experience them. And until we find a way to document them, we will not understand them.

Stress can be bad for you. We no longer die of smallpox or the plague and instead die of stress-related diseases of lifestyle, like heart disease or diabetes, where damage slowly accumulates over time. It is understood how stress can cause or worsen disease or make you more vulnerable to other risk factors. Much of this is even understood on the molecular level. Stress can even cause your immune system to abnormally target hair follicles, causing your hair to turn gray.

Suddenly I realized that a cell's life is controlled by the physical and energetic environment and not by its genes. Genes are simply molecular blueprints used in the construction of cells, tissues, and organs. The environment serves as a "contractor" who reads and engages those genetic blueprints and is ultimately responsible for the character of a cell's life. It is a single cell's "awareness" of the environment, not its genes, that sets into motion the mechanisms of life.

The living cell is the most complex system of its size known to mankind. Its host of specialized molecules, many found nowhere else but within living material, are themselves already enormously complex. They execute a dance of exquisite fidelity, orchestrated with breathtaking precision. Vastly more elaborate than the most complicated ballet, the dance of life encompasses countless molecular performers in synergetic coordination. Yet this is a dance with no sign of a choreographer. No intelligent supervisor, no mystic force, no conscious controlling agency swings the molecules into place at the right time, chooses the appropriate players, closes the links, uncouples the partners, moves them on. The dance of life is spontaneous, self-sustaining, and self-creating.

Molecular machines display a key signature or hallmark of design, namely, irreducible complexity. In all irreducibly complex systems in which the cause of the system is known by experience or observation, intelligent design or engineering played a role in the origin of the system... We find such systems within living organisms.

But in the last century or so, the culture of medicine has largely been shaped by an exuberant overemphasis on the biologic and molecular phenomena of disease. Improving the social conditions that shape health has become an afterthought.

Nonetheless, the appeal of Copenhagen makes some sense, seen in this light. Quantum physics drove much of the technological and scientific progress of the past ninety years: nuclear power, modern computers, the Internet. Quantum-driven medical imaging changed the face of health care; quantum imaging techniques at smaller scales have revolutionized biology and kicked off the entirely new field of molecular genetics. The list goes on. Make some kind of personal peace with Copenhagen, and contribute to this amazing revolution in science . . . or take quantum physics seriously, and come face-to-face with a problem that even Einstein couldn't solve. Shutting up never looked so good.

Nuclear didn't describe families. How could it? Dry physics was not equal to that task. In the twentieth century we needed a biological metaphor, Darwinian in scope, to suggest the gnash and crash of carnivorous life in the family gene pool. But for the 21st century, the new century, I think the metaphors must be chemical. Molecular. In the molecular family people are connected without being bound. They spindle themselves around shared experiences and affections rather than splashing in the shared gene pool.

I feel like the caterpillar that we think is making a choice when he eats or pupates but, in fact, is not. He's ruled by molecular forms of incluence acting on the base components of a moth. Likewise, perhaps I have become a killer through circumstances acting on my biological make-up. Which means, of course, that none of this is my fault and that it's all out of my hands.

Nanotechnology will enable the design of nanobots: robots designed at the molecular level, measured in microns (millionths of a meter), such as “respirocytes” (mechanical red-blood cells).33 Nanobots will have myriad roles within the human body, including reversing human aging (to the extent that this task will not already have been completed through biotechnology, such as genetic engineering).

Twin, family, and population studies have all conclusively shown that psychological traits are at least partly, and sometimes largely, heritable—that is, a sizable portion of the variation that we see in these traits across the population is attributable to genetic variation. However, as we have seen in the preceding chapters, the relationship between genes and traits is far from simple. The fact that a given trait is heritable seems to suggest that there must be genes for that trait. But phrasing it in that way is a serious conceptual trap. It implies that genes exist that are dedicated to that function—that there are genes for intelligence or sociability or visual perception. But this risks confusing the two meanings of the word gene: one, from the study of heredity, refers to genetic variants that affect a trait; the other, from molecular biology, refers to the stretches of DNA that encode proteins with various biochemical or cellular functions.

The truth is that anxiety is at once a function of biology and philosophy, body and mind, instinct and reason, personality and culture. Even as anxiety is experienced at a spiritual and psychological level, it is scientifically measurable at the molecular level and the physiological level. It is produced by nature and it is produced by nurture. It’s a psychological phenomenon and a sociological phenomenon. In computer terms, it’s both a hardware problem (I’m wired badly) and a software problem (I run faulty logic programs that make me think anxious thoughts). The origins of a temperament are many faceted; emotional dispositions that may seem to have a simple, single source—a bad gene, say, or a childhood trauma—may not.

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired. Evolution has produced chemical compounds exquisitely organized to accomplish the most complicated and delicate of tasks. Many organic chemists viewing crystal structures of enzyme systems or nucleic acids and knowing the marvels of specificity of the immune systems must dream of designing and synthesizing simpler organic compounds that imitate working features of these naturally occurring compounds.

Exploring all I could find, often with reckless dedication, I devoured the philosophies and theologies of animistic and shamanistic traditions. Hungrily I began learning: how to feel connection with the wind and the waves, how to hear the songs of the land and the stories of the ancestors, how to dissolve into darkness and ride the thermals of light. Slowly I discovered how these traditions are still alive, not just in lands that, with a mix of disquiet and envy, Western cultures call primitive and uncivilized. Returning to the islands of my ancestors, with wonder and relief, I found animistic religions in the rolling hills and flowering gardens of Britain. To my surprise and delight, I found too that here my passion for science was as nurtured as my soul’s artistic creativity. There was nothing in quantum physics or molecular biology, or the theories of the physiology of consciousness that could negate my growing understanding and experience of sanctity. I found the power of reason here, naturally inherent within the language of a religion.

The differentiation of science into its specialties is, after all, an artificial and man-made state of affairs. While the level of knowledge was still low, the division was useful and seemed natural. It was possible for a man to study astronomy or biology without reference to chemistry or physics, or for that matter to study either chemistry or physics in isolation. With time and accumulated information, however, the borders of the specialties approached, met, and finally overlapped. The- techniques of one science became meaningful and illuminating in another. In the latter half of the nineteenth century, physical techniques made it possible to determine the chemical constitution and physical structure of stars, and the science of "astrophysics" was born. The study of the vibrations set up in the body of the earth by quakes gave rise to the study of "geophysics." 'Me study of chemical reactions through physical techniques initiated and constantly broadened the field of "physical chemistry," and the latter in turn penetrated the study of biology to produce what we now call "molecular biology.

Much of the literature on creativity focuses on how to trigger these moments of innovative synthesis; how to drive the problem phase toward its resolution. And it turns out that epiphanies often happen when we are in one of two types of environment. The first is when we are switching off: having a shower, going for a walk, sipping a cold beer, daydreaming. When we are too focused, when we are thinking too literally, we can’t spot the obscure associations that are so important to creativity. We have to take a step back for the “associative state” to emerge. As the poet Julia Cameron put it: “I learned to get out of the way and let that creative force work through me.”8 The other type of environment where creative moments often happen, as we have seen, is when we are being sparked by the dissent of others. When Kevin Dunbar, a psychologist at McGill University, went to look at how scientific breakthroughs actually happen, for example (he took cameras into four molecular biology labs and recorded pretty much everything that took place), he assumed that it would involve scientists beavering away in isolated contemplation. In fact, the breakthroughs happened at lab meetings, where groups of researchers would gather around a desk to talk through their work. Why here? Because they were forced to respond to challenges and critiques from their fellow researchers. They were jarred into seeing new associations.

The Melding Plague attacked our society at the core. It was not quite a biological virus, not quite a software virus, but a strange and shifting chimera of the two. No pure strain of the plague has ever been isolated, but in its pure form it must resemble a kind of nano-machinery, analogous to the molecular-scale assemblers of our own medichine technology. That it must be of alien origin seems beyond doubt. Equally clear is the fact that nothing we have thrown against the plague has done more than slow it. More often than not, our interventions have only made things worse. The plague adapts to our attacks; it perverts our weapons and turns them against us. Some kind of buried intelligence seems to guide it. We don’t know whether the plague was directed toward humanity—or whether we have just been terribly unlucky.

Mates are … an intense thing for the Fae.” She swallowed audibly. “It’s a lifetime commitment. Something sworn between bodies and hearts and souls. It’s a binding between beings. You say I’m your mate in front of any Fae, and it’ll mean something big to them.” “And we don’t mean something big like that?” he asked carefully, hardly daring to breathe. She held his heart in her hands. Had held it since day one. “You mean everything to me,” she breathed, and he exhaled deeply. “But if we tell Ruhn that we’re mates, we’re as good as married. To the Fae, we’re bound on a biological, molecular level. There’s no undoing it.” “Is it a biological thing?” “It can be. Some Fae claim they know their mates from the moment they meet them. That there’s some kind of invisible link between them. A scent or soul-bond.” “Is it ever between species?” “I don’t know,” she admitted, and ran her fingers over his chest in dizzying, taunting circles. “But if you’re not my mate, Athalar, no one is.” “A winning declaration of love.” She scanned his face, earnest and open in a way she so rarely was with others. “I want you to understand what you’re telling people, telling the Fae, if you say I’m your mate.” “Angels have mates. Not as … soul-magicky as the Fae, but we call life partners mates in lieu of husbands or wives.” Shahar had never called him such a thing. They’d rarely even used the term lover. “The Fae won’t differentiate. They’ll use their intense-ass definition.” He studied her contemplative face. “I feel like it fits. Like we’re already bound on that biological level.” “Me too. And who knows? Maybe we’re already mates.

By one billion years ago, plants, working cooperatively, had made a stunning change in the environment of the Earth. Green plants generate molecular oxygen. Since the oceans were by now filled with simple green plants, oxygen was becoming a major constituent of the Earth’s atmosphere, altering it irreversibly from its original hydrogen-rich character and ending the epoch of Earth history when the stuff of life was made by nonbiological processes. But oxygen tends to make organic molecules fall to pieces. Despite our fondness for it, it is fundamentally a poison for unprotected organic matter. The transition to an oxidizing atmosphere posed a supreme crisis in the history of life, and a great many organisms, unable to cope with oxygen, perished. A few primitive forms, such as the botulism and tetanus bacilli, manage to survive even today only in oxygen-free environments. The nitrogen in the Earth’s atmosphere is much more chemically inert and therefore much more benign than oxygen. But it, too, is biologically sustained. Thus, 99 percent of the Earth’s atmosphere is of biological origin. The sky is made by life.

The final misconception is that evolution is “just a theory.” I will boldly assume that readers who have gotten this far believe in evolution. Opponents inevitably bring up that irritating canard that evolution is unproven, because (following an unuseful convention in the field) it is a “theory” (like, say, germ theory). Evidence for the reality of evolution includes: Numerous examples where changing selective pressures have changed gene frequencies in populations within generations (e.g., bacteria evolving antibiotic resistance). Moreover, there are also examples (mostly insects, given their short generation times) of a species in the process of splitting into two. Voluminous fossil evidence of intermediate forms in numerous taxonomic lineages. Molecular evidence. We share ~98 percent of our genes with the other apes, ~96 percent with monkeys, ~75 percent with dogs, ~20 percent with fruit flies. This indicates that our last common ancestor with other apes lived more recently than our last common ancestor with monkeys, and so on. Geographic evidence. To use Richard Dawkins’s suggestion for dealing with a fundamentalist insisting that all species emerged in their current forms from Noah’s ark—how come all thirty-seven species of lemurs that made landfall on Mt. Ararat in the Armenian highlands hiked over to Madagascar, none dying and leaving fossils in transit? Unintelligent design—oddities explained only by evolution. Why do whales and dolphins have vestigial leg bones? Because they descend from a four-legged terrestrial mammal. Why should we have arrector pili muscles in our skin that produce thoroughly useless gooseflesh? Because of our recent speciation from other apes whose arrector pili muscles were attached to hair, and whose hair stands up during emotional arousal.