Modify Car Quotes

Sometimes I'd see my father, walking past my building on his way to another nowhere. I could have given him a key, offered a piece of my floor. A futon. A bed. But I never did. If I let him inside I would become him, the line between us would blur, my own slow-motion car wreck would speed up. The slogan on the side of a moving company truck read TOGETHER WE ARE GOING PLACES--modified by a vandal or a disgruntled employee to read TOGETHER WE ARE GOING DOWN. If I went to the drowning man the drowning man would pull me under. I couldn't be his life raft.

But you know so many men,” Ophelia said, “isn’t there even one for you?” “They’re all adjectives,” I said, “they all make me feel modified; even a word like girl friend gives me this feeling I’ve been cut in half. I’d rather just be a car, not a blue car or a big one, than sit there the rest of my life being stuck with some adjective.

What are the true reasons why the purchaser is planning to spend his money on a new car instead of a piano? Because he has decided that he wants the commodity called locomotion more than he wants the commodity called music? Not altogether. He buys a car, because it is at the moment the group custom to buy cars. The modern propagandist therefore sets to work to create circumstances which will modify that custom . . . He will endeavor to develop public acceptance of the idea of a music room in the home. This he may do, for example, by organizing an exhibition of period music rooms designed by well-known decorators who themselves exert an influence on the buying groups . . . Then, in order to create dramatic interest in the exhibit, he stages an event or ceremony. To this ceremony key people, persons known to influence the buying habits of the public, such as a famous violinist, a popular artist, and a society leader, are invited. These key persons affect other groups, lifting the idea of the music room to a place in the public consciousness which it did not have before. The juxtaposition of these leaders, and the idea which they are dramatizing, are then projected to the wider public through various publicity channels . . . The music room will be accepted because it has been made the thing. And the man or woman who has a music room, or has arranged a corner of the parlor as a musical corner, will naturally think of buying a piano. It will come to him as his own idea.

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To use a more accurate car metaphor, the Honda Civic, like the pit bull, is small in size, fairly generic in appearance, inexpensive, and easy to acquire. These four characteristics make it one of the best-selling cars of all time. For those exact same reasons, the Civic is also the leading car bought, sold, and modified for purposes of street drag racing, a highly dangerous and illegal practice that kills approximately one hundred Americans every year (three times as many as are killed by all types of dogs combined). Yet no legislator has ever proposed a ban on the Honda Civic in order to correct errant human behavior by a small number of people. If

What are the true reasons why the purchaser is planning to spend his money on a new car instead of a piano? Because he has decided that he wants the commodity called locomotion more than he wants the commodity called music? Not altogether. He buys a car, because it is at the moment the group custom to buy cars. The modern propagandist therefore sets to work to create circumstances which will modify that custom. He appeals perhaps to the home instinct which is fundamental. He will endeavor to develop public acceptance of the idea of a music room in the home. This he may do, for example, by organizing an exhibition . . . key people, persons known to influence the buying habits of the public, such as a famous violinist, a popular artist, and a society leader, are invited. These key persons affect other groups, lifting the idea of the music room to a place in the public consciousness which it did not have before. The juxtaposition of these leaders, and the idea which they are dramatizing, are then projected to the wider public through various publicity channels . . . The music room will be accepted because it has been made the thing. And the man or woman who has a music room, or has arranged a corner of the parlor as a musical corner, will naturally think of buying a piano. It will come to him as his own idea.

They WERE walking alongside the road, they WERE hit by a car, and now they ARE dead. It doesn't work. Are is present tense. Dead is -- well, dead is past, isn't it? Present tense modifying past; being modifying non-being. Language, in this instance" -- and here Miriam makes a garbled noise in her throat-- "fails.

Cette rapidité décroît régulièrement à mesure qu'il s'avance vers le nord, et il faut souhaiter que cette régularité persiste, car, si, comme on a cru le remarquer, sa vitesse et sa direction viennent à se modifier, les climats européens seront soumis à des perturbations dont on ne saurait calculer les conséquences.

You hear it in every political speech, “vote for me, we’ll get the dream back.” They all reiterate it in similar words—you even hear it from people who are destroying the dream, whether they know it or not. But the “dream” has to be sustained, otherwise how are you going to get people in the richest, most powerful country in world history, with extraordinary advantages, to face the reality that they see around them? Inequality is really unprecedented. If you look at total inequality today, it’s like the worst periods of American history. But if you refine it more closely, the inequality comes from the extreme wealth in a tiny sector of the population, a fraction of 1 percent. There were periods like the Gilded Age in the 1890s and the Roaring Twenties and so on, when a situation developed rather similar to this, but the current period is extreme. Because if you look at the wealth distribution, the inequality mostly comes from super-wealth—literally, the top one-tenth of a percent are just super-wealthy. This is the result of over thirty years of a shift in social and economic policy. If you check you find that over the course of these years the government policy has been modified completely against the will of the population to provide enormous benefits to the very rich. And for most of the population, the majority, real incomes have almost stagnated for over thirty years. The middle class in that sense, that unique American sense, is under severe attack. A significant part of the American Dream is class mobility: You’re born poor, you work hard, you get rich. The idea that it is possible for everyone to get a decent job, buy a home, get a car, have their children go to school . . . It’s all collapsed.

Ireland, like Ukraine, is a largely rural country which suffers from its proximity to a more powerful industrialised neighbour. Ireland’s contribution to the history of tractors is the genius engineer Harry Ferguson, who was born in 1884, near Belfast. Ferguson was a clever and mischievous man, who also had a passion for aviation. It is said that he was the first man in Great Britain to build and fly his own aircraft in 1909. But he soon came to believe that improving efficiency of food production would be his unique service to mankind. Harry Ferguson’s first two-furrow plough was attached to the chassis of the Ford Model T car converted into a tractor, aptly named Eros. This plough was mounted on the rear of the tractor, and through ingenious use of balance springs it could be raised or lowered by the driver using a lever beside his seat. Ford, meanwhile, was developing its own tractors. The Ferguson design was more advanced, and made use of hydraulic linkage, but Ferguson knew that despite his engineering genius, he could not achieve his dream on his own. He needed a larger company to produce his design. So he made an informal agreement with Henry Ford, sealed only by a handshake. This Ford-Ferguson partnership gave to the world a new type of Fordson tractor far superior to any that had been known before, and the precursor of all modern-type tractors. However, this agreement by a handshake collapsed in 1947 when Henry Ford II took over the empire of his father, and started to produce a new Ford 8N tractor, using the Ferguson system. Ferguson’s open and cheerful nature was no match for the ruthless mentality of the American businessman. The matter was decided in court in 1951. Ferguson claimed $240 million, but was awarded only $9.25 million. Undaunted in spirit, Ferguson had a new idea. He approached the Standard Motor Company at Coventry with a plan, to adapt the Vanguard car for use as tractor. But this design had to be modified, because petrol was still rationed in the post-war period. The biggest challenge for Ferguson was the move from petrol-driven to diesel-driven engines and his success gave rise to the famous TE-20, of which more than half a million were built in the UK. Ferguson will be remembered for bringing together two great engineering stories of our time, the tractor and the family car, agriculture and transport, both of which have contributed so richly to the well-being of mankind.

it would cost $250,000. Musk declared that insane and told Mueller they should make it themselves. They were able to do so in months at a fraction of the cost. Another supplier quoted a price of $120,000 for an actuator that would swivel the nozzle of the upper-stage engines. Musk declared it was not more complicated than a garage door opener, and he told one of his engineers to make it for $5,000. Jeremy Hollman, one of the young engineers working for Mueller, discovered that a valve that was used to mix liquids in a car wash system could be modified to work with rocket fuel.

It’s true, organic food is more expensive to grow, and we have to be willing to pay for it. Some people see that as a luxury. I always come back to the same question: Would we rather give our money to the farmer or the pharmacist, the grocer or the doctor? Do we want to spend a fortune in the future trying to fix the damage being done today? Once we compare the potential risk and reward, the extra cost of eating clean food may seem worth it. Eating is the single most important thing we can do to stay healthy. If good, clean food isn’t worth our money, what is? Organic blackberries cost double the normal kind? How does that compare to the price of chemotherapy? How does burning out your insides with toxic chemicals and destroying your immune system and puking out your guts and losing all your hair stack up against spending three dollars more on that organic produce? Your body responds to what you put inside it. It’s simple. How could anything else be possible? You’d accept that if we were talking about your car. Why not your body? Clean also means food that contains no genetically modified organisms—GMOs. This is the really scary stuff, and it’s in the news every day as the big corporations fight every effort to label engineered foods. The fact that the industry is against truth in labeling tells us all we need to know.

When the same genes are repeatedly activated by the same information from the brain, then the genes keep getting selected over and over again, and just like gears in a car, they start to wear out. The body makes proteins with weaker structures and lesser functions. We get sick and we age. In time, one of two scenarios can occur. The intelligence of the cell membrane, which is consistently receiving the same information, can adapt to the body’s needs and demands by modifying its receptor sites so that it can accommodate more of those chemicals. Basically, it creates more docking stations to satisfy the demand—just as supermarkets open up additional checkout lanes when the lines get too long.

Parental efforts to gain leverage generally take two forms: bribery or coercion. If a simple direction such as “I'd like you to set the table” doesn't do, we may add an incentive, for example, “If you set the table for me, I'll let you have your favorite dessert.” Or if it isn't enough to remind the child that it is time to do homework, we may threaten to withdraw some privilege. Or we may add a coercive tone to our voice or assume a more authoritarian demeanor. The search for leverage is never-ending: sanctions, rewards, abrogation of privileges; the forbidding of computer time, toys, or allowance; separation from the parent or separation from friends; the limitation or abolition of television time, car privileges, and so on and so on. It is not uncommon to hear someone complain about having run out of ideas for what still might remain to be taken away from the child. As our power to parent decreases, our preoccupation with leverage increases. Euphemisms abound: bribes are called variously rewards, incentives, and positive reinforcement; threats and punishments are rechristened warnings, natural consequences, and negative reinforcements; applying psychological force is often referred to as modifying behavior or teaching a lesson. These euphemisms camouflage attempts to motivate the child by external pressure because his intrinsic motivation is deemed inadequate. Attachment is natural and arises from within; leverage is contrived and imposed from without. In any other realm, we would see the use of leverage as manipulation. In parenting, such means of getting a child to follow our will have become embraced by many as normal and appropriate. All attempts to use leverage to motivate a child involve the use of psychological force, whether we employ “positive” force as in rewards or “negative” force as in punishments. We apply force whenever we trade on a child's likes or when we exploit a child's dislikes and insecurities in order to get her to do our will. We resort to leverage when we have nothing else to work with — no intrinsic motivation to tap, no attachment for us to lean on. Such tactics, if they are ever to be employed, should be a last resort, not our first response and certainly not our modus operandi. Unfortunately, when children become peer-oriented, we as parents are driven to leverage-seeking in desperation. Manipulation, whether in the form of rewards or punishments, may succeed in getting the child to comply temporarily, but we cannot by this method make the desired behavior become part of anyone's intrinsic personality. Whether it is to say thank-you or sorry, to share with another, to create a gift or card, to clean up a room, to be appreciative, to do homework, or to practice piano, the more the behavior has been coerced, the less likely it is to occur voluntarily. And the less the behavior occurs spontaneously, the more inclined parents and teachers are to contrive some leverage. Thus begins a spiraling cycle of force and counterwill that necessitates the use of more and more leverage. The true power base for parenting is eroded.

Google unveiled its latest driverless car. It plans to build 100 prototypes from scratch, rather than modifying others’ vehicles as it has done in the past. The car has no steering wheel or pedals, only a “stop” and a “go” button. The two-seater electric vehicle can travel up to 25mph (40kph) and the firm hopes to pilot it on Californian roads within two years. However, there remain significant regulatory and legal barriers to its spread.

Western medical practitioners, except for a few enlightened exceptions, still regard the human body as a car and discuss problems and solutions in mechanical terms. If the human being is not working properly, for example, the solution is to find and change the defective part or in some way modify it.

Imagine trying to jerry-rig a Volkswagen Beetle to travel at speeds of 150 miles per hour. In 1933, Adolf Hitler commissioned Dr. Ferdinand Porsche to develop a cheap car that could get 40 miles per gallon of gas and provide a reliable form of transportation for the average German family. The result was the VW Beetle. This history, Hitler’s plan, places constraints on the ways we can modify the Beetle today; the engineering can be tweaked only so far before major problems arise and the car reaches its limit. In many ways, we humans are the fish equivalent of a hot-rod Beetle. Take the body plan of a fish, dress it up to be a mammal, then tweak and twist that mammal until it walks on two legs, talks, thinks, and has superfine control of its fingers—and you have a recipe for problems. We can dress up a fish only so much without paying a price. In a perfectly designed world—one with no history—we would not have to suffer everything from hemorrhoids to cancer.

The 49-year-old Bryant, who resembles a cereal box character himself with his wide eyes, toothy smile, and elongated chin, blames Kellogg's financial woes on the changing tastes of fickle breakfast eaters. The company flourished in the Baby Boom era, when fathers went off to work and mothers stayed behind to tend to three or four children. For these women, cereal must have been heaven-sent. They could pour everybody a bowl of Corn Flakes, leave a milk carton out, and be done with breakfast, except for the dishes. Now Americans have fewer children. Both parents often work and no longer have time to linger over a serving of Apple Jacks and the local newspaper. Many people grab something on the way to work and devour it in their cars or at their desks while checking e-mail. “For a while, breakfast cereal was convenience food,” says Abigail Carroll, author of Three Squares: The Invention of the American Meal. “But convenience is relative. It's more convenient to grab a breakfast bar, yogurt, a piece of fruit, or a breakfast sandwich at some fast-food place than to eat a bowl of breakfast cereal.” People who still eat breakfast at home favor more laborintensive breakfasts, according to a recent Nielsen survey. They spend more time at the stove, preparing oatmeal (sales were up 3.5 percent in the first half of 2014) and eggs (up 7 percent last year). They're putting their toasters to work, heating up frozen waffles, French toast, and pancakes (sales of these foods were up 4.5 percent in the last five years). This last inclination should be helping Kellogg: It owns Eggo frozen waffles. But Eggo sales weren't enough to offset its slumping U.S. cereal numbers. “There has just been a massive fragmentation of the breakfast occasion,” says Julian Mellentin, director of food analysis at research firm New Nutrition Business. And Kellogg faces a more ominous trend at the table. As Americans become more healthconscious, they're shying away from the kind of processed food baked in Kellogg's four U.S. cereal factories. They tend to be averse to carbohydrates, which is a problem for a company selling cereal derived from corn, oats, and rice. “They basically have a carb-heavy portfolio,” says Robert Dickerson, senior packagedfood analyst at Consumer Edge. If such discerning shoppers still eat cereal, they prefer the gluten-free kind, sales of which are up 22 percent, according to Nielsen. There's also growing suspicion of packagedfood companies that fill their products with genetically modified organisms (GMOs). For these breakfast eaters, Tony the Tiger and Toucan Sam may seem less like friendly childhood avatars and more like malevolent sugar traffickers.

For one, a modified vegetable oil that makes asphalt less likely to crack in the winter or turn to tar in the summer. Cargill started selling it two years ago and has already shipped 30 million pounds of the product around the world. The plan is to be selling 100 million pounds of it a year by 2020. Another big win could be soybean oil that can be tweaked into foam for car seats.

L’homme sait aujourd’hui que la terre n’est qu’une boule animée d’un mouvement multiforme et vertigineux qui court sur un abîme insondable, attirée et dominée par les forces qu’exercent sur elle d’autres corps célestes, incomparablement plus grands et situés à des distances inimaginables ; il sait que la terre où il vit n’est qu’un grain de poussière par rapport au soleil, et que le soleil lui-même n’est qu’un grain au milieu de myriades d’autres astres incandescents ; il sait aussi que tout cela bouge. Une simple irrégularité dans cet enchaînement de mouvements sidéraux, l’interférence d’un astre étranger dans le système planétaire, une déviation de la trajectoire normale du soleil, ou tout autre incident cosmique, suffirait pour faire vaciller la terre au cours de sa révolution, pour troubler la succession des saisons, modifier l’atmosphère et détruire l’humanité. L’homme aujourd’hui sait par ailleurs que le moindre atome renferme des forces qui, si elles étaient déchaînées, pourraient provoquer sur terre une conflagration planétaire presque instantanée. Tout cela, l’“infiniment petit” et l’“infiniment grand”, apparaît, du point de vue de la science moderne, comme un mécanisme d’une complexité inimaginable, dont le fonctionnement est dû à des forces aveugles. Et pourtant, l’homme d’aujourd’hui vit et agit comme si le déroulement normal et habituel des rythmes de la nature lui était garanti. Il ne pense, en effet, ni aux abîmes du monde intersidéral, ni aux forces terribles que renferme chaque corpuscule de matière. Avec des yeux d’enfant, il regarde au-dessus de lui la voûte céleste avec le soleil et les étoiles, mais le souvenir des théories astronomiques l’empêche d’y voir des signes de Dieu. Le ciel a cessé de représenter pour lui la manifestation naturelle de l’esprit qui englobe le monde et l’éclaire. Le savoir universitaire s’est substitué en lui à cette vision “naïve” et profonde des choses. Non qu’il ait maintenant conscience d’un ordre cosmique supérieur, dont l’homme serait aussi partie intégrante. Non. Il se sent comme abandonné, privé d’appui solide face à ces abîmes qui n’ont plus aucune commune mesure avec lui-même. Car rien ne lui rappelle plus désormais que tout l’univers, en définitive, est contenu en lui-même, non pas dans son être individuel, certes, mais dans l’esprit qui est en lui et qui, en même temps, le dépasse, lui et tout l’univers visible.

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Dès le premier film, [...] j'avais été fascinée par l'espace de vie japonais et par ces portes coulissantes refusant de pourfendre l'espace et glissant en douceur sur des rails invisibles. Car, lorsque nous ouvrons une porte, nous transformons les lieux de bien mesquine façon. Nous heurtons leur pleine extension et introduisons une brèche malavisée à force de mauvaises proportions. Si on y réfléchit bien, il n'y a rien de plus laid qu'une porte ouverte. Dans la pièce où elle se trouve, elle introduit comme une rupture, un parasitage provincial qui brise l'unité de l'espace. Dans la pièce contiguë, elle engendre une dépression, une fissure béante et néanmoins stupide, perdue sur un bout de mur qui eût préféré être entier. Dans les deux cas, elle perturbe l'étendue sans autre contrepartie que la licence de circuler, laquelle peut pourtant être assurée par bien d'autres procédés. La porte coulissante, elle, évite les écueils et magnifie l'espace. Sans en modifier l'équilibre, elle en permet la métamorphose. Lorsqu'elle s'ouvre, deux lieux communiquent sans s'offenser. Lorsqu'elle se ferme, elle redonne à chacun son intégrité. Le partage et la réunion se font sans intrusion. La vie y est une calme promenade, lors qu'elle s'apparente chez nous à une longue suite d'effractions.

D’autre part, nous avons eu aussi l’occasion de faire remarquer la faiblesse, pour ne pas dire plus, de l’attitude qu’on est convenu d’appeler « apologétique », et qui consiste à vouloir défendre une tradition contre des attaques telles que celles de la science moderne en discutant les arguments de celle-ci sur son propre terrain, ce qui ne va presque jamais sans entraîner des concessions plus ou moins fâcheuses, et ce qui implique en tout cas une méconnaissance du caractère transcendant de la doctrine traditionnelle. Cette attitude est habituellement celle d’exotéristes, et l’on peut penser que, bien souvent, ils sont surtout poussés par la crainte qu’un plus ou moins grand nombre d’adhérents de leur tradition ne s’en laissent détourner par les objections scientifiques ou soi-disant telles qui sont formulées contre elle ; mais, outre que cette considération « quantitative » est elle-même d’un ordre assez profane, ces objections méritent d’autant moins qu’on y attache une telle importance que la science dont elles s’inspirent change continuellement, ce qui devrait suffire à prouver leur peu de solidité. Quand on voit, par exemple, des théologiens se préoccuper d’« accorder la Bible avec la science », il n’est que trop facile de constater combien un tel travail est illusoire, puisqu’il est constamment à refaire à mesure que les théories scientifiques se modifient, sans compter qu’il a toujours l’inconvénient de paraître solidariser la tradition avec l’état présent de la science profane, c’est-à-dire avec des théories qui ne seront peut-être plus admises par personne au bout de quelques années, si même elles ne sont pas déjà abandonnées par les savants, car cela aussi peut arriver, les objections qu’on s’attache à combattre ainsi étant plutôt ordinairement le fait des vulgarisateurs que celui des savants eux-mêmes. Au lieu d’abaisser maladroitement les Écritures sacrées à un pareil niveau, ces théologiens feraient assurément beaucoup mieux de chercher à en approfondir autant que possible le véritable sens, et de l’exposer purement et simplement pour le bénéfice de ceux qui sont capables de le comprendre, et qui, s’ils le comprenaient effectivement, ne seraient plus tentés par là même de se laisser influencer par les hypothèses de la Science profane, non plus d’ailleurs que par la « critique » dissolvante d’une exégèse moderniste et rationaliste, c’est-à-dire essentiellement anti-traditionnelle, dont les prétendus résultats n’ont pas davantage à être pris en considération par ceux qui ont conscience de ce qu’est réellement la tradition. [La science profane devant les doctrines traditionnelles]

- Rien n'est moins sûr. Mais, pour le cas où les jurés m'auraient lu, croyez bien que ça ne change rien à ma théorie. Il y a tant de gens qui poussent la sophistication jusqu'à lire sans lire. Comme des hommes-grenouilles, ils traversent les livres sans prendre une goutte d'eau. - Oui, vous en aviez parlé au cours d'une entrevue précédente. - Ce sont les lecteurs-grenouilles. Ils forment l'immense majorité des lecteurs humains, et pourtant je n'ai découvert leur existence que très tard. Je suis d'une telle naïveté. Je pensais que tout le monde lisait comme moi ; moi, je lis comme je mange : ça ne signifie pas soulement que j'en ai besoin, ça signifie surtout que ça entre dans mes composantes et que ça les modifie. On n'est pas le même selon qu'on a mangé du boudin ou du caviar ; on n'est pas le même non plus selon qu'on vient de lire du Kant (Dieu m'en préserve ) ou du Queneau. Enfin, quand je dis , je devrais dire , car la plupart des gens émergent de Proust ou de Simenon dans un état identique, sans avoir perdu une miette de ce qu'ils étaient et sans avoir acquis une miette supplémentaire. Ils ont lu, c'est tout : dans le meilleur des cas, ils savent .

When deployed in rap vernacular, the word villain feels slightly anachronistic, particularly when prefaced by the adjective mother-fuckin’. It’s a little old-timey. But there simply wasn’t a word that better described N.W.A’s public aspirations with such accuracy. I suppose gangsta is the only other word that came close, a modifier so flexible it could even be used to describe how rappers operated their cars. If you lowered the seat and tilted your body toward the vehicle’s passenger side, the posture was referred to as the “gangsta lean.” Spawned in 1972 by forgotten R&B wunderkind William DeVaughn, “gangsta lean” is an amazingly evocative term, particularly to those who did not initially know what it meant. But once you unpacked the definition, it merely outlined a villainous way to drive your jalopy to White Castle, operating from the position that appearing villainous was an important way to appear at all possible times. This was very, very important to the members of N.W.A. It was the only thing they seemed to worry about. Everything they attempted had to possess criminal undertones. I can only assume they spent hours trying to deduce villainous ways to microwave popcorn (and if they’d succeeded, there would absolutely be a song about it, assumedly titled “Pop Goes the Corn Killa” or “45 Seconds to Bitch Snack”).

C’est pour créer cette illusion qu’on a inventé le « suffrage universel » : c’est l’opinion de la majorité qui est supposée faire la loi ; mais ce dont on ne s’aperçoit pas, c’est que l’opinion est quelque chose que l’on peut très facilement diriger et modifier ; on peut toujours, à l’aide de suggestions appropriées, y provoquer des courants allant dans tel ou tel sens déterminé ; nous ne savons plus qui a parlé de « fabriquer l’opinion », et cette expression est tout à fait juste, bien qu’il faille dire, d’ailleurs, que ce ne sont pas toujours les dirigeants apparents qui ont en réalité à leur disposition les moyens nécessaires pour obtenir ce résultat. Cette dernière remarque donne sans doute la raison pour laquelle l’incompétence des politiciens les plus « en vue » semble n’avoir qu’une importance très relative ; mais, comme il ne s’agit pas ici de démonter les rouages de ce qu’on pourrait appeler la « machine à gouverner », nous nous bornerons à signaler que cette incompétence même offre l’avantage d’entretenir l’illusion dont nous venons de parler : c’est seulement dans ces conditions, en effet, que les politiciens en question peuvent apparaître comme l’émanation de la majorité, étant ainsi à son image, car la majorité, sur n’importe quel sujet qu’elle soit appelée à donner son avis, est toujours constituée par les incompétents, dont le nombre est incomparablement plus grand que celui des hommes qui sont capables de se prononcer en parfaite connaissance de cause.

Censoring Measuring response rate and progression offers more problems than measurement error. We may not be considering the right denominator of patients. In 2017, the FDA approved the first cellular cancer therapy, called tisagenlecleucel (Kymriah, Novartis), or CAR-T, for short. A CAR-T is a chimeric antigen receptor T-cell, basically a genetically modified cell taken from a patient that is trained to attack cancer cells and then placed back in the patient. In the data submitted to the FDA, 88 patients had the cells removed, but 18% (16/88) did not receive the cells because some patients died and some patients’ cells could not be manufactured.17 Unfortunately, the FDA excluded these patients from the denominator and assessed response only in patients who got the cells. This violates a principle called intention to treat, that is, you should judge a drug based on all patients allocated to get it, irrespective of whether or not they received it. Why? Because therapies that take a long time to give (this CAR-T took approximately 22 days to make) may exclude the sickest patients who die while waiting, thus distorting their benefit. In fact, if I have a patient in my office and we decide to treat with tisagenlecleucel, the response rate from the package overestimates her chances of success, as I am unsure she will live long enough to receive the cells.

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I like to explain stability using an analogy from my favorite sport, auto racing. A few years ago I drove to a racetrack in Southern California to spend a couple of days training with my coach. To warm up, I took a few “sedan laps” in my street car at the time, a modified BMW M3 coupe with a powerful 460+ HP engine. After months of creeping along on clogged Southern California freeways, it was hugely fun to dive into the corners and fly down the straightaways. Then I switched to the track car we had rented, basically a stripped-down, race-worthy version of the popular BMW 325i. Although this vehicle’s engine produced only about one-third as much power (165 HP) as my street car, my lap times in it were several seconds faster, which is an eternity in auto racing. What made the difference? The track car’s 20 percent lighter weight played a part, but far more important were its tighter chassis and its stickier, race-grade tires. Together, these transmitted more of the engine’s force to the road, allowing this car to go much faster through the corners. Though my street car was quicker in the long straights, it was much slower overall because it could not corner as efficiently. The track car was faster because it had better stability. Without stability, my street car’s more powerful engine was not much use. If I attempted to drive it through the curves as fast as I drove the track car, I’d end up spinning into the dirt. In the context of the gym, my street car is the guy with huge muscles who loads the bar with plates but who always seems to be getting injured (and can’t do much else besides lift weights in the gym). The track car is the unassuming-looking dude who can deadlift twice his body weight, hit a fast serve in tennis, and then go run up a mountain the next day. He doesn’t necessarily look strong. But because he has trained for stability as well as strength, his muscles can transmit much more force across his entire body, from his shoulders to his feet, while protecting his vulnerable back and knee joints. He is like a track-ready race car: strong, fast, stable—and healthy, because his superior stability allows him to do all these things while rarely, if ever, getting injured.

In 1922, a fourteen-year-old boy with type 1 diabetes was resuscitated from a coma—born anew, as it were—by the infusion of insulin extracted from the pancreatic cells of a dog. In 2010, when Emily Whitehead received her infusion of CAR (chimeric antigen receptor) T cells, or twelve years later, when the first patients with sickle cell anemia are surviving, disease-free, with gene-modified blood stem cells, we are transitioning from the century of the gene to a contiguous, overlapping century of the cell.

The game FR Legends MOD APK is all about drifting and racing. You can customize your car and participate in various drift competitions. The game has a variety of cars to choose from, and you can modify them according to your preferences. The game also has different tracks that you can race on, and each track has its own unique challenges.

Embury was the first true cocktailian of the modern age, and he took time to analyze the components of a cocktail, breaking them down into a base (usually a spirit, it must be at least 50 percent of the drink); a modifying, smoothing, or aromatizing agent, such as vermouth, bitters, fruit juice, sugar, cream, or eggs; and “additional special flavoring and coloring ingredients,” which he defined as liqueurs and nonalcoholic fruit syrups. Embury taught us that the Ramos Gin Fizz must be shaken for at least five minutes in order to achieve the proper silky consistency, suggested that Peychaud’s bitters be used in the Rob Roy, and noted that “for cocktails, such as the Side Car, a three-star cognac is entirely adequate, although a ten-year-old cognac will produce a better drink.” In the second edition of his book, Embury mentioned that he had been criticized for omitting two drinks from his original work: the Bloody Mary, which he described as “strictly vile,” and the Moscow Mule, as “merely mediocre.” On the subject of Martinis, he explained that although most cocktail books call for the drink to be made with one-third to one-half vermouth, “quite recently, in violent protest of this wishy-washy type of cocktail, there has sprung up the vermouth-rinse method of making Martinis.” He describes a drink made from chilled gin in a cocktail glass coated in vermouth. Embury didn’t approve of either version, and went on to say that a ratio of seven parts gin to one part vermouth was his personal favorite. While Embury was taking his drinking seriously, many Americans were quaffing Martinis by the pitcher, and Playboy magazine commissioned cocktail maven Thomas Mario and, later, Emanuel Greenberg to deliver cocktail news to a nation of people who drank for fun, and did it on a regular basis. Esquire magazine issued its Handbook for Hosts as early as 1949, detailing drinks such as the Sloe Gin Fizz, the Pan American, the “I Died Game, Boys” Mixture, and the Ginsicle—gin with fruit juice or simple syrup poured over chipped ice in a champagne glass. A cartoon in the book depicts a frustrated bartender mopping his fevered brow and exclaiming, “She ordered it because it had a cute name.” The world of cocktails was tilting slightly on its axis, and liquor companies lobbied long and hard to get into the act. In the fifties, Southern Comfort convinced us to make Comfort Manhattans and Comfort Old-Fashioneds by issuing a booklet: How to Make the 32 Most Popular Drinks. By the seventies, when the Comfort Manhattan had become the Improved Manhattan, they were bringing us Happy Hour Mixology Plus a Primer of Happy Hour Astrology, presumably so we would have something to talk about at bars: “Oh, you’re a Virgo—discriminating, keenly analytical, exacting, and often a perfectionist. Wanna drink?

Because the library had been built in the 1800s, the main entrance was designed to accommodate horse-drawn carriages, although very few people arrived that way nowadays, so it had been modified into a drop-off area for cars.

Je pensais que tout le monde lisait comme moi; moi, je lis comme je mange: ça ne signifie pas seulement que j'en ai besoin, ça signifie surtout que ça entre dans mes composantes et que ça les modifie. On n'est pas le même selon qu'on a mangé du boudin ou du caviar; on n'est pas le même non plus selon qu'on vient de lire du Kant (Dieu m'en préserve) ou du Queneau. Enfin, quand je dis "on", je devrais dire "moi et quelques autres", car la plupart des gens émergent de Proust ou de Simenon dans un état identique sans avoir perdu une miette de ce qu'ils étaient et sans avoir acquis une miette supplémentaire. Ils ont lu, c'est tout: dans le meilleur des cas, ils savent "ce dont il s'agit". Ne croyez pas que je brode. Combien de fois ai-je demandé, à des personnes intelligentes "Ce livre vous a-t-il changé?" Et on me regardait, les yeux ronds, l'air de dire: "Pourquoi voulez-vous qu'il me change?

Où Est La Marijuana À Vendre? ] < < < Télégramme: Broklyn07382 * COMMENT TROUVER LE TEMPS D'ACHETER L'ÉTAGÈRE SUPÉRIEURE * MARIJUANA + BOURGEONS + FLEURS TWITTER Comment est-ce que je fais de la marijuana? La marijuana est la partie séchée de la plante de marijuana. Il contient des produits chimiques qui modifient votre conscience et votre humeur. La consommation de marijuana a des effets à court et à long terme. Les consommateurs de marijuana ont tendance à avoir moins d'estime de soi, moins de confiance et moins de relations. Des doses élevées peuvent entraîner une surdose, de l'anxiété et de la panique. Les personnes qui consomment de la marijuana peuvent également perdre le contact avec la réalité et avoir des hallucinations. Voici les coordonnées des vendeurs de marijuana légitimes ci-dessous: Chaîne de télégramme : jerrymushkush Compte Telegram: Broklyn07382 wickr: charleskolu420 Pour cultiver du cannabis, vous avez besoin d'un endroit sûr pour que ses racines se développent. Le cannabis ne peut pas prospérer sans racines saines. Des racines saines permettent à la plante d'absorber l'eau et les nutriments et de s'ancrer au sol. Pour fournir l'environnement optimal à vos plantes de cannabis, utilisez des plateaux ou des récipients réutilisés avec des trous dans le fond. Assurez-vous qu'il y a un drainage adéquat car les pots gorgés d'eau peuvent entraîner la pourriture des racines. De plus, installez un drainage pour que les plants de marijuana ne restent pas dans l'eau tout le temps. Voici les coordonnées des vendeurs de marijuana légitimes ci-dessous: Chaîne de télégramme : jerrymushkush Compte Telegram: Broklyn07382 wickr: charleskolu420 La marijuana est une plante dont les feuilles, les fleurs et d'autres parties sont séchées et fumées. Il existe également des variétés de marijuana à plus forte puissance, communément appelées haschisch, sinsemilla et extraits. La marijuana contient plus de 500 produits chimiques, le delta-9-tétrahydrocannabinol, ou THC, étant responsable de la plupart de ses effets psychotropes. Voici les coordonnées des vendeurs de marijuana légitimes ci-dessous: Chaîne de télégramme : jerrymushkush Compte Telegram: Broklyn07382 wickr: charleskolu420

Supporters of the psi-mediated instrumental response (PMIR) model and first-sight model and theory (FSMT) would probably say yes. PMIR is a model for channeling experiences that happen spontaneously in daily life. It proposes that people unconsciously get information that is relevant to what they need. They then unconsciously use this information to modify their behavior to meet their needs (Stanford 2015), just like I was unconsciously late and avoided a car accident. PMIR refers to the psychological ways that channeling might function in a person’s life that serves their inherent qualities of mind and character and needs. It basically says that you use channeling without any conscious effort or awareness that it is even happening. Similarly, the first-sight model and theory (FSMT) proposes that it is in your essential nature to participate actively, all the time, and unconsciously in your world. And that your world is much larger in time and space than your immediate boundaries. All of your experiences and behaviors result from unconscious psychological processes that are acted out based on multiple sources of information, including those beyond your traditional five senses (Carpenter, n.d.). FSMT proposes that channeling is not an ability that needs to be nurtured or trained or coaxed into working but an innate universal characteristic of all living organisms.

[...] C’est pour créer cette illusion qu’on a inventé le « suffrage universel » : c’est l’opinion de la majorité qui est supposée faire la loi ; mais ce dont on ne s’aperçoit pas, c’est que l’opinion est quelque chose que l’on peut très facilement diriger et modifier ; on peut toujours, à l’aide de suggestions appropriées, y provoquer des courants allant dans tel ou tel sens déterminé ; nous ne savons plus qui a parlé de « fabriquer l’opinion », et cette expression est tout à fait juste, bien qu’il faille dire, d’ailleurs, que ce ne sont pas toujours les dirigeants apparents qui ont en réalité à leur disposition les moyens nécessaires pour obtenir ce résultat. Cette dernière remarque donne sans doute la raison pour laquelle l’incompétence des politiciens les plus « en vue » semble n’avoir qu’une importance très relative ; mais, comme il ne s’agit pas ici de démonter les rouages de ce qu’on pourrait appeler la « machine à gouverner », nous nous bornerons à signaler que cette incompétence-même offre l’avantage d’entretenir l’illusion dont nous venons de parler : c’est seulement dans ces conditions, en effet, que les politiciens en question peuvent apparaître comme l’émanation de la majorité, étant ainsi à son image, car la majorité, sur n’importe quel sujet qu’elle soit appelée à donner son avis, est toujours constituée par les incompétents, dont le nombre est incomparablement plus grand que celui des hommes qui sont capables de se prononcer en parfaite connaissance de cause.

Israël est l’essence de la spiritualité proprement judaïque et le patriarche éponyme du peuple juif. Étymologiquement, ce Nom est lié à une idée de puissance et de victoire, car il signifie : ≪ que Dieu règne ! Qu’Il se montre fort ! ≫. Et c’est ce Nom sacré qui va être porte par un Etat moderne, subversif dans sa constitution même puisqu’il prétend mettre fin par des moyens profanes a une sanction divine ! Il faut toute l’indifférence et l’inconscience du monde occidentale pour ne pas réaliser l’énormité d’une telle usurpation. Imagine-t-on une ≪ République d’Allah ≫, un ≪ Royaume du Christ-Roi ≫ ou ≪ du Voyage Nocturne ≫ s’installant en Palestine ? En l’occurrence, l’acte profanateur est d’autant plus dangereux qu’il comporte une astuce tactique. La préoccupation majeure d’un Etat illégitime, pour ne pas dire sa hantise, est naturellement d’être reconnu. Or, dans le cas présent cette reconnaissance ne porte pas seulement sur l’existence de cet Etat, mais aussi sur le droit à porter le nom qu’il s’est attribué. Reconnaître l’ ≪ Etat d’Israël ≫ implique que l’on valide la profanation dont il s’est rendu coupable, que l’on devienne son complice, et surtout qu’on le déclare, à tort, favorisé par une bénédiction divine et investi de la charge d’instaurer le règne de Dieu et d’assurer Sa puissance. Combattre un tel Etat, c’est le renforcer ; le reconnaître, c’est le renforcer davantage : tel est le dilemme infernal. Pour tout esprit traditionnel, la seule attitude légitime, fondée à la fois sur la vérité et le droit, est de refuser cette reconnaissance, quel que soit le prix à payer pour ce déni. Le premier devoir d’un juif orthodoxe, d’un chrétien ou d’un musulman est de ne pas reconnaître l’Etat juif. Ceci dit, il va de soi que la duplicité et la faiblesse des hommes n’ont pas le pouvoir de modifier le Droit divin ou de le rendre caduc. En vertu de sa mission propre et grâce à sa position cyclique, l’islam est mieux à même que toute autre religion de veiller au respect de ce Droit et au maintien de l’orthodoxie traditionnelle. On peut tenir pour assuré qu’il n’acceptera jamais le fais accompli.