Miller Urey Quotes

IN 1953, STANLEY Miller, a graduate student at the University of Chicago, took two flasks—one containing a little water to represent a primeval ocean, the other holding a mixture of methane, ammonia, and hydrogen sulphide gases to represent Earth’s early atmosphere—connected them with rubber tubes, and introduced some electrical sparks as a stand-in for lightning. After a few days, the water in the flasks had turned green and yellow in a hearty broth of amino acids, fatty acids, sugars, and other organic compounds. “If God didn’t do it this way,” observed Miller’s delighted supervisor, the Nobel laureate Harold Urey, “He missed a good bet.

Stanley Miller and Harold Urey, was to simulate the conditions on Earth in primordial times, three or four billion years ago, when life appeared for the first time. The experiments were intended to see if they could make something come alive using nothing but nonliving chemicals. Do you know what emerged? Not life, but something fascinating all the same. The chemicals gave rise to significant chemical compounds: a handful of amino acids, essential components in the chemistry of life. Amino acids are molecules that hook together to form the proteins that run almost every aspect of biology.

Misplaced belief in the Miller-Urey experiment continues. A 2011 study of twenty-two high school textbooks found that nineteen discuss the Miller-Urey experiment as a possible explanation of the origin of life.4 I have met many people who think life began simply because lightning struck some primeval pond billions of years ago. The Disney movie Fantasia contains such a scene, set to the music of Stravinsky’s “Rite of Spring.” Despite this popular perception, the Miller-Urey experiment is no longer considered good science. We

More than fifty years have passed since the flask experiments by Stanley Miller and Harold Urey rekindled the primordial soup hypothesis for the origin of life. Scientists now realize, however, that generating miniscule amounts of a few amino acids is irrelevant to the origin of life because the chemicals in Miller and Urey’s experiment were exposed to neither oxygen nor ultraviolet light. The fact that Earth never possessed measurable quantities of prebiotics (see p. 73) and that the universe appears devoid of reservoirs for life’s fundamental chemical building blocks (see p. 74) also argues for the famed experiment’s irrelevance. As far back as 1973, a deep sense of frustration over any possible naturalistic explanation for life’s origin on Earth or anywhere else within the vast reaches of interstellar space led Francis Crick (who shared the Nobel Prize for the discovery of the double helix nature of DNA) and Leslie Orgel (one of the world’s preeminent origin-of-life researchers) to suggest that intelligent aliens must have salted Earth with bacteria about 3.8 billion years ago.[24] This suggestion, however intriguing or bizarre, fails to answer the question of where the aliens might have come from. It also contradicts evidence that shows intelligent life could not have arrived on the cosmic scene any sooner than about 13.7 billion years after the cosmic origin event. The implausibility of interstellar space travel also remains an intractable problem. Ruling out a visit by aliens from a planetary system far, far away narrows the reasonable options down to one: Something or Someone from beyond the physics and dimensions of the universe, who is not subject to them, placed life and humanity in the only location in the universe at the only time in cosmic history where and when such creatures could survive and thrive.

New York Times article from March 8, 1953, titled “Looking Back Two Billion Years.” “Obviously,” Edmond said, “this experiment raised some eyebrows. The implications could have been earth-shattering, especially for the religious world. If life magically appeared inside this test tube, we would know conclusively that the laws of chemistry alone are indeed enough to create life. We would no longer require a supernatural being to reach down from heaven and bestow upon us the spark of Creation. We would understand that life simply happens…as an inevitable by-product of the laws of nature. More importantly, we would have to conclude that because life spontaneously appeared here on earth, it almost certainly did the same thing elsewhere in the cosmos, meaning: man is not unique; man is not at the center of God’s universe; and man is not alone in the universe.” Edmond exhaled. “However, as many of you may know, the Miller-Urey experiment failed. It produced a few amino acids, but nothing even closely resembling life. The chemists tried repeatedly, using different combinations of ingredients, different heat patterns, but nothing worked. It seemed that life—as the faithful had long believed—required divine intervention. Miller and Urey eventually abandoned their experiments. The religious community breathed a sigh of relief, and the scientific community went back to the drawing board.” He paused, an amused glimmer in his eyes. “That is, until 2007…when there was an unexpected development.” Edmond now told the tale of how the forgotten Miller-Urey testing vials had been rediscovered in a closet at the University of California in San Diego after Miller’s death. Miller’s students had reanalyzed the samples using far more sensitive contemporary techniques—including liquid chromatography and mass spectrometry—and the results had been startling. Apparently, the original Miller-Urey experiment had produced many more amino acids and complex compounds than Miller had been able to measure at the time. The new analysis of the vials even identified several important nucleobases—the building blocks of RNA, and perhaps eventually…DNA. “It was an astounding science story,” Edmond concluded, “relegitimizing the notion that perhaps life does simply happen…without divine intervention. It seemed the Miller-Urey experiment had indeed been working, but just needed more time to gestate. Let’s remember one key point: life evolved over billions of years, and these test tubes had been sitting in a closet for just over fifty. If the timeline of this experiment were measured in miles, it was as if our perspective were limited to only the very first inch…” He let that thought hang in the air. “Needless to say,” Edmond went on, “there was a sudden resurgence in interest surrounding the idea of creating life in a lab.” I remember that, Langdon thought. The Harvard biology faculty had thrown