Metabolic Conditioning Quotes

The simplest way to look at all these associations, between obesity, heart disease, type 2 diabetes, metabolic syndrome, cancer, and Alzheimer's (not to mention the other the conditions that also associate with obesity and diabetes, such as gout, asthma, and fatty liver disease), is that what makes us fat - the quality and quantity of carbohydrates we consume - also makes us sick.

Today, of course, there’s no need to forage and hunt to survive. Yet our genes are coded for this activity, and our brains are meant to direct it. Take that activity away, and you’re disrupting a delicate biological balance that has been fine-tuned over half a million years. Quite simply, we need to engage our endurance metabolism to keep our bodies and brains in optimum condition. The ancient rhythms of activity ingrained in our DNA translate roughly to the varied intensity of walking, jogging, running, and sprinting. In broad strokes, then, I think the best advice is to follow our ancestors’ routine: walk or jog every day, run a couple of times a week, and then go for the kill every now and then by sprinting.

Labor is the activity which corresponds to the biological process of the human body, whose spontaneous growth, metabolism, and eventual decay are bound to the vital necessities produced and fed into the life process by labor. The human condition of labor is life itself.

Gordon Shepherd MD and PhD at Yale School of Medicine, said this: “The industry is geared to over-stimulating the senses of the consumer so that they eat more. The goal is to activate the parts of the brain that are susceptible to being conditioned to finding a product desirable and then wanting more of it.

In our need for more and more rapid replacement of the worldly things around us, we can no longer afford to use them, to respect and preserve their inherent durability; we must consume, devour, as it were, our houses and furniture and cars as though they were the “good things” of nature which spoil uselessly if they are not drawn swiftly into the never-ending cycle of man’s metabolism with nature. It is as though we had forced open the distinguishing boundaries which protected the world, the human artifice, from nature, the biological process which goes on in its very midst as well as the natural cyclical processes which surround it, delivering and abandoning to them the always threatened stability of a human world.

The importance of eating enough prebiotic fiber is one of the reasons you hear the bad advice to eat plenty of grains, legumes, and beans. These foods do contain prebiotic fiber, which does great things for your metabolism. Unfortunately, as I highlighted in The Bulletproof Diet, they also contain plant defense compounds called lectins, which damage your gut lining and cause inflammation and autoimmune conditions.

Six out of ten adults are living with a chronic illness. About 50 percent of Americans will deal with mental illness sometime in life. Seventy-four percent of adults are overweight or have obesity. Rates of cancer, heart disease, kidney disease, upper respiratory infections, and autoimmune conditions are all going up at the exact time we are spending more and more to treat them. In the face of these trends, American life expectancy has been declining for the most sustained period since 1860.

We have established on thermodynamic grounds that to make a cell from scratch requires a continuous flow of reactive carbon and chemical energy across rudimentary catalysts in a constrained through-flow system. Only hydrothermal vents provide the requisite conditions, and only a subset of vents – alkaline hydrothermal vents – match all the conditions needed. But alkaline vents come with both a serious problem and a beautiful answer to the problem. The serious problem is that these vents are rich in hydrogen gas, but hydrogen will not react with CO2 to form organics. The beautiful answer is that the physical structure of alkaline vents – natural proton gradients across thin semiconducting walls – will (theoretically) drive the formation of organics. And then concentrate them. To my mind, at least, all this makes a great deal of sense. Add to this the fact that all life on earth uses (still uses!) proton gradients across membranes to drive both carbon and energy metabolism, and I’m tempted to cry, with the physicist John Archibald Wheeler, ‘Oh, how could it have been otherwise! How could we all have been so blind for so long!’ Let

Downstairs in the body, sleep restocks the armory of our immune system, helping fight malignancy, preventing infection, and warding off all manner of sickness. Sleep reforms the body’s metabolic state by fine-tuning the balance of insulin and circulating glucose. Sleep further regulates our appetite, helping control body weight through healthy food selection rather than rash impulsivity. Plentiful sleep maintains a flourishing microbiome within your gut from which we know so much of our nutritional health begins. Adequate sleep is intimately tied to the fitness of our cardiovascular system, lowering blood pressure while keeping our hearts in fine condition.

A trauma is a place where it becomes impossible to remain connected in and to the present moment. Trauma is a part of the human condition! Healing is also a part of the human condition, and we have the capacity to transform difficult experiences into a wellspring of personal and spiritual power. Trauma occurs when there is a rupture in our boundary system and our capacity to metabolize an experience is compromised. Every single human being on earth has trauma. It's an interruption of our ability to stay in the present moment, anything that lags or is not harmonized on the layers of body/mind/spirit/soul/psyche. Rachael Maddox has called it an" embodied interpersonal violation hangover." Ale Duarte called it "an open loop." Lately, many people have been telling me their stories and then telling me how they are "lucky," that "it's not that bad" compared to other people's situations. All of those statements happen in the mind, and they are largely attempts to keep ourselves from feeling the depth of our pain or sorrow. We may have white privilege, we may have class privilege, we may have had homebirth privilege—the animals of our bodies don't actually understand mental and philosophical constructs like privilege. What those constructs contribute to on an individual healing level is a lot of confusion, shame and guilt, that in spite of everything we "have," we may have still experienced helplessness, hurt, anger, or outrage or collapse, or whatever it is that our system felt. We actually cannot control those responses.

Life expectancy has increased primarily because of sanitation practices and infectious disease mitigation measures; because of emergency surgery techniques for acute and life-threatening conditions, like an inflamed appendix or trauma; and because of antibiotics to reverse life-threatening infections. In short, almost every “health miracle” we can point to is a cure for an acute issue (i.e., a problem that would kill you imminently if left unresolved). Economically, acute conditions aren’t great in our modern system, because the patient is quickly cured and no longer a customer. Starting in the 1960s, the medical system has taken the trust engendered by these acute innovations and used it to ask patients not to question its authority on chronic diseases (which can last a lifetime and thus are more profitable).

I ran to Sailor’s hutch to see if he’d made it through alive. He was backed into the corner, shivering, and in the most wretched condition: he had become so malnourished that his fur had grown horribly long, his body’s attempt to compensate for his slow metabolism and low temperature. His claws were an inch long, and worse, his front teeth had curled over his lower lip so he could hardly open his mouth. Apparently, rabbits need to be chewing on hard things like carrots; otherwise their teeth will grow. Terrified, I opened the cage door to hug little Sailor, but, in a spastic fury, he started scratching my face and neck. I still have the scars. Without anyone attending to him, he had gone feral. That’s what’s happened to me, in Seattle. Come at me, even in love, and I’ll scratch the hell out of you. ’Tis a piteous fate to have befallen a MacArthur genius, wouldn’t you say? Poof. But I do love you, Bernadette TUESDAY, DECEMBER 14 From Paul Jellinek Bernadette, Are you done?

Ocean Acidification is sometimes referred to as Global Warming's Equally Evil Twin. The irony is intentional and fair enough as far as it goes... No single mechanism explains all the mass extinctions in the record and yet changes in ocean chemistry seem to be a pretty good predictor. Ocean Acidification played a role in at least 2 of the Big Five Extinctions: the End-Permian and the End-Triassic. And quite possibly it was a major factor in a third, the End-Cretaceous. ...Why is ocean acidification so dangerous? The question is tough to answer only because the list of reasons is so long. Depending on how tightly organisms are able to regulate their internal chemistry, acidification may affect such basic processes as metabolism, enzyme activity, and protein function. Because it will change the makeup of microbial communities, it will alter the availability of key nutrients, like iron and nitrogen. For similar reasons, it will change the amount of light that passes through the water, and for somewhat different reasons, it will alter the way sound propagates. (In general, acidification is expected to make the seas noisier.) It seems likely to promote the growth of toxic algae. It will impact photosynthesis—many plant species are apt to benefit from elevated CO2 levels—and it will alter the compounds formed by dissolved metals, in some cases in ways that could be poisonous. Of the myriad possible impacts, probably the most significant involves the group of creatures known as calcifiers. (The term calcifier applies to any organism that builds a shell or external skeleton or, in the case of plants, a kind of internal scaffolding out of the mineral calcium carbonate.)... Ocean acidification increases the cost of calcification by reducing the number of carbonate ions available to organisms that build shells or exoskeletons. Imagine trying to build a house while someone keeps stealing your bricks. The more acidified the water, the greater the energy that’s required to complete the necessary steps. At a certain point, the water becomes positively corrosive, and solid calcium carbonate begins to dissolve. This is why the limpets that wander too close to the vents at Castello Aragonese end up with holes in their shells. According to geologists who work in the area, the vents have been spewing carbon dioxide for at least several hundred years, maybe longer. Any mussel or barnacle or keel worm that can adapt to lower pH in a time frame of centuries presumably already would have done so. “You give them generations on generations to survive in these conditions, and yet they’re not there,” Hall-Spencer observed.

They basically suggest that specificity allows for a handful of neurons, whose activity is too faint to be measurable, to hypothetically explain lifetimes of complex and coherent experiences. Resuscitation specialist Dr. Sam Parnia’s candid rebuttal of this suggestion seems to frame it best: ‘When you die, there’s no blood flow going into your brain. If it goes below a certain level, you can’t have electric activity. It takes a lot of imagination to think there’s somehow a hidden area of your brain that comes into action when everything else isn’t working.’38 But even if we grant that there is hidden neural activity somewhere, the materialist position immediately raises the question of why we are born with such large brains if only a handful of neurons were sufficient to confabulate unfathomable dreams. After all, as a species, we pay a high price for our large brains in terms of metabolism and in terms of having to be born basically premature, since a more developed head cannot pass through a woman’s birth canal. Moreover, under ordinary conditions, it has been scientifically demonstrated that we generate measurable neocortical activity even when we dream of the mere clenching of a hand!39 It is, thus, incoherent to postulate that undetectable neural firings – the extreme of specificity – are sufficient to explain complex experiences.

With the term vita activa, I propose to designate three fundamental human activities: labor, work, and action. They are fundamental because each corresponds to one of the basic conditions under which life on earth has been given to man. Labor is the activity which corresponds to the biological process of the human body, whose spontaneous growth, metabolism, and eventual decay are bound to the vital necessities produced and fed into the life process by labor. The human condition of labor is life itself. Work is the activity which corresponds to the unnaturalness of human existence, which is not imbedded in, and whose mortality is not compensated by, the species’ ever-recurring life cycle. Work provides an “artificial” world of things, distinctly different from all natural surroundings. Within its borders each individual life is housed, while this world itself is meant to outlast and transcend them all. The human condition of work is worldliness. Action, the only activity that goes on directly between men without the intermediary of things or matter, corresponds to the human condition of plurality, to the fact that men, not Man, live on the earth and inhabit the world. While all aspects of the human condition are somehow related to politics, this plurality is specifically the condition—not only the conditio sine qua non, but the conditio per quam—of all political life. Thus the language of the Romans, perhaps the most political people we have known, used the words “to live” and “to be among men” (inter homines esse) or “to die” and “to cease to be among men” (inter homines esse desinere) as synonyms.

Over time, the active verbs of the Shema-recite, walk, talk, lie down, rise, bind, fix, write, all in the service of love-become too much for us to imagine, let alone perform. Our search for superpowers has created many of the most pressing problems of our time. The defining mental activity of our time is scrolling Our capacities of attention, memory, and concentration are diminishing; to compensate, we toggle back and forth between infinite feeds of news, posts, images, episodes - taking shallow hits of trivia, humor, and outrage to make up for the depths of learning, joy, and genuine lament that now feel beyond our reach. The defining illness of our time is metabolic syndrome, the chronic combination of high weight, high cholesterol, high blood pressure, and high blood sugar that is the hallmark of an inactive life. Our strength is atrophying and our waistline expanding, and to compensate, we turn to the superpowers of the supermarket with the aisles of salt and fat convincing our bodies’ reward systems, one bite at a time, that we have never been better in our life. The defining emotional challenge of our time is anxiety, the fear of what might be instead of the courageous pursuit of what could be. Once, we lived with allness of heart, with a boldness of quest that was too in love with the good to call off the pursuit when we encountered risk. Now we live as voyeurs, pursuing shadowy vestiges of what we desire from behind the one-way mirror of a screen, invulnerable but alone. And, of course, the soul is the plane of human ex- istence that our technological age neglects most of all. Jesus asked whether it was worth gaining the whole world at the cost of losing one's soul. But in the era of superpowers, we have not only lost a great deal of our souls-we have lost much of the world as well. We are rarely overwhelmed by wind or rain or snow. We rarely see, let alone name, the stars. We have lost the sense that we are both at home and on a pilgrimage in the vast, mysterious cosmos, anchored in a rich reality beyond ourselves. We have lost our souls without even gaining the world. So it is no wonder that the defining condition of our time is a sense of loneliness and alienation. For if human flourishing requires us to love with all our hearts, souls, minds, and strength, what happens When nothing in our lives develops those capacities? With what, exactly, will we love?

Prospective data indicates that the CRP is a better predictor of cardiovascular risk than a low-density lipoprotein (LDL) cholesterol, the standby predictor of cardiovascular disease. The CRP advantage is that “inflammation,” (but not the elevated LDL) is associated with the components of the metabolic syndrome. CRP levels are not only demonstrated with “inflammation” of cardiovascular disease, but also with triglycerides, obesity, elevated blood pressure, and elevated fasting blood glucose. In addition, CRP also correlates with endothelial dysfunction, impaired fibrinolysis, and most importantly, insulin resistance, which is hyperinsulinemia, type 2 diabetes. I ask you, the reader, to please note that the clinical conditions associated with CRP, especially its application for cardiovascular disease, is the pathology of insulin resistance, hyperinsulinemia, type 2 diabetes. Please see Chapter 14, Pathology of Type 2 Diabetes.

Labour is, first of all, a process between man and nature, a process by which man, through his own actions, mediates, regulates and controls the metabolism between himself and nature. He confronts the materials of nature as a force of nature. He sets in motion the natural forces which belong to his own body, his arms, legs, head and hands, in order to appropriate the materials of nature in a form adapted to his own needs. Through this movement he acts upon external nature and changes it, and in this way he simultaneously changes his own nature. . . . It [the labor process] is the universal condition for the metabolic interaction [Stoffwechsel] between man and nature, the everlasting nature-imposed condition of human existence.

If we look at a map of the world today, one of the striking observations is that illnesses like Crohn’s disease are common in more developed countries and rare in less developed ones. The hygiene hypothesis accounts for this uneven distribution by suggesting that less childhood exposure to bacteria and parasites in affluent societies like the United States and Europe actually increases susceptibility to disease by suppressing the natural development of the immune system. This concept has also been linked to the rise of many of our chronic ailments: the obesity epidemic, deadly disorders like metabolic syndrome and heart disease, psychiatric conditions like depression, poorly understood afflictions like autism, and even some forms of cancer—and clinical studies have shown significant disturbances in the microbiome in all of them. We spend huge amounts of time making sure we’re clean—scrubbing ourselves with harsh soaps, sanitizing our hands and environment with chemicals, and eliminating any trace of dirt from our homes and lives—but since the evidence suggests that germs may actually be essential for our well-being, it may be time to rethink our approach to cleanliness and hygiene.

Make a conscious point to actively ENJOY every bite of the stuff that you’ve conditioned yourself to believe is unhealthy with intense focus every time you decide to eat it.

All these phenomena-scores of them-are captured, encapsulated in a myriad of devices, and replicated, some many thousands of times in as many thousands of identical components. That all these phenomena are caught and captured and schooled and put to work in parallel at exactly the right temperature and pressure and airflow conditions; that all these execute in concert with exactly the right timing; that all these persist despite extremes of vibration and heat and stress; that all these perform together to produce tens of thousands of pounds of thrust is not to be taken for granted. It is a wonder. Seen this way, a technology in operation-in this case a jet engine-ceases to be a mere object at work. It becomes a metabolism. This is not a familiar way to look at any technology. But what I mean is that the technology becomes a complex of interactive processes-a complex of captured phenomena-supporting each other, using each other, "conversing" with each other, "calling" each other much as subroutines in computer programs call each other. The "calling" here need not be triggered in some sequence as in computing. It is ongoing and continuously interactive. Some assemblies are on, some are off; some operate continuously. Some operate in sequence; some operate in parallel. Some are brought in only in abnormal conditions.

Abundant data support the importance of biodiversity in health, and its loss causes various inflammatory conditions, including asthma, allergic and inflammatory bowel diseases, type 1 diabetes, liver disease, obesity, and much more.

Richter compares the conditions of rat domestication with those now provided by the 'Welfare State'-ample food, no danger, no stress, uniform environment and climate, and so forth. But he notes that, under these seemingly favorable conditions, organic deterioration has taken place: a decrease in the size of the adrenal glands, which help the organism meet stress or fatigue and forfend certain diseases: while the thyroid gland, the regulator of metabolism, becomes less active. Not strangely, perhaps, the brains of the domestic rat, and perhaps their mental ability, are smaller. At the same time, the sex glands mature earlier, become bigger, show more activity, and result in a higher rate of fertility. How human!

1. GROWTH HORMONES IN MEAT When you eat conventional meat, you’re probably eating hormones, antibiotics, steroids, and chemicals created by the fear and stress suffered by the animal during slaughter and in its inhumane living conditions. In 2009, two Japanese researchers published a startling study in Annals of Oncology. They pointed out that there has been a surge in hormone-dependent cancers that roughly parallels the surge of beef consumption in Japan. Over the last twenty-five years, hormone-dependent cancers such as breast, ovarian, endometrial, and prostate cancer rose fivefold in that country. More than 25 percent of the beef imported to Japan comes from the United States, where livestock growers regularly use the growth hormonal steroid estradiol. The researchers found that US beef had much higher levels of estrogen than Japanese beef because of the added hormones. This finding led them to conclude that eating a lot of estrogen-rich beef could be the reason for the rising incidence of these life-threatening cancers. Injected hormones like estrogen mimic the activity of our natural hormones and prevent those hormones from doing their jobs. This situation creates chaos. Growth hormones may alter the way in which natural hormones are produced, eliminated, or metabolized. And guess what? Hormone impersonators can trigger unnatural cell growth that may develop into cancer. The United States is one of the only industrialized countries that still allows their animals to be injected with growth hormone. Australia, New Zealand, Canada, Japan, and the entire European Union have banned rBGH and rBST because of their dangerous impact on human and bovine health. US farmers fatten up their livestock by injecting them with estrogen-based hormones, which can migrate from the meat we eat to our bodies—and possibly stimulate the growth of human breast cancer, according to the Breast Cancer Fund, an organization committed to preventing breast cancer by

Someone starts out sedentary, overweight, and somewhat insulin resistant. They set out to improve their health and lose some weight by following a low-carb diet. It works great. They lose weight, their insulin sensitivity improves, and their energy is through the roof. They start exercising, which helps them lose some more weight, as well as build some lean muscle mass. Now they are really into it, and the frequency and intensity of their training increases. This individual is now at a healthy weight (or relatively lean), is exercising regularly, and has better insulin sensitivity. They are a completely different person, metabolically speaking, then when they started. But the problem is they are no longer properly fueling their body and recovering from their intense training sessions (which were once non-existent). They are starting to feel tired and fatigued in the gym, are always in a bad mood, are holding on to stubborn body fat, can’t sleep at night, get sick all of the time, and are maybe having some sexual performance and hormonal issues. Their diet no longer matches their new activity levels and current metabolic condition, because those have completely changed over time. If this person objectively looked at their situation and progress and listened to their own body and biofeedback, they would consider some dietary adjustments. A moderate-to-higher carb intake might be a better fit. But some people will cling to a diet that initially gave them good results, and got them from Point A to Point B, thinking it will get them from Point B to Point C. I’ve been there myself. Part of it is initial experience, part of it is marketing material, and part of it is pure emotion. It doesn’t always work that way for continued progress.

she exercised so much while consuming a limited diet, Kate’s condition caused her body to perceive her well-meaning tactics as deprivation, and this activated a powerful weight defense system that made her body store all her fuel as fat for protection.

The Whole30 rules and meal recommendations also target a sluggish metabolism, helping you restore a healthy hormonal balance, effectively regulate blood sugar, and become “fat adapted” (able to use dietary and body fat as fuel). Over time, the overconsumption of foods with no brakes conditions your body to rely on sugar for energy, leaving you unable to burn the fat stored on your body, and requiring you to eat every few hours to maintain energy, focus, and a pleasant demeanor.

By perceiving obesity as an eating disorder, a defect of behavior rather than physiology, and by perceiving excessive hunger as the cause of obesity, rather than a symptom that accompanies the drive to gain weight, those investigators concerned with human obesity had managed to dissociate the perception of hunger and satiety from any underlying metabolic conditions.

require chronic or recurrent treatment with a wide array of medications, some of which could aff ect insulin sensitivity, �-cell function, or other aspects of glucoregulation. Whenever feasible, preference should be given to those agents that are either neutral or beneficial in their eff ects on carbohydrate and lipid metabolism. In the sections that follow, diff erent classes of medications will be discussed with regard to their impact on diabetes risk. These medication classes were selected for discussion based either on (a) their historical association with dysglycemia in clinical practice, (b) extensive utilization for the management of comorbid conditions (e.g., hypertension, dyslipidemia) in diabetic patients, or (c) existing or emerging reports of possible association with

Either it’s beyond their control, in which case there is another, more profound cause of their condition—perhaps a metabolic or hormonal disorder for which we should still be searching—or it is within their control, and so we are led to the judgment that the obese are weaker of will than the lean.

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The same review of obesity research mentioned earlier also reported a large decrease in fasting insulin levels, which is an indication of improving insulin and glucose metabolism, lowering the risk of insulin resistance, prediabetic and diabetic conditions, high blood sugar levels, and hyperglycemia.

In fact, it’s now thought that lipotoxicity may be a central cause of insulin resistance in our tissues. It’s been known for a long time that people who have inflammatory conditions, like rheumatoid arthritis, are more prone to type 2 diabetes, as inflammation promotes insulin resistance. As such, it really must be addressed first and foremost in any plan to reverse PCOS symptoms.

Beaudart, C., et al. (2017), Nutrition and physical activity in the prevention and treatment of sarcopenia: Systematic review, Osteoporosis International 28:1817–33; Lozano-Montoya, I. (2017), Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: A systematic overview—the SENATOR Project ONTOP Series, Clinical Interventions in Aging 12:721–40. 55. Fiatarone, M. A., et al. (1990), High-intensity strength training in nonagenarians: Effects on skeletal muscle, Journal of the American Medical Association 263:3029–34. 56. Donges, C. E., and Duffield, R. (2012), Effects of resistance or aerobic exercise training on total and regional body composition in sedentary overweight middle-aged adults, Applied Physiology, Nutrition, and Metabolism 37:499–509; Mann, S., Beedie, C., and Jimenez, A. (2014), Differential effects of aerobic exercise, resistance training, and combined exercise modalities on cholesterol and the lipid profile: Review, synthesis, and recommendations, Sports Medicine 44:211–21. 57. Phillips, S. M., et al. (1997), Mixed muscle protein synthesis and breakdown after resistance exercise in humans, American Journal of Physiology 273:E99–E107; McBride, J. M. (2016), Biomechanics of resistance exercise, in Haff and Triplett, Essentials of Strength Training and Conditioning, 19–42.

The third most abundant substance in breast milk is an oligosaccharide. Babies don’t digest it directly. Rather, it nourishes a bacterium called Bifidobacterium infantis, transmitted through vaginal birth and wiped out by antibiotics, and now thought to be missing in most American babies. B. infantis is essential in programming our metabolic operations. Those who maintain a healthy population of the bacterium are less likely to become overweight, experience allergies, or have Type 1 diabetes. But the majority don’t, which leaves them prone to numerous autoimmune diseases, colon and rectal cancers, allergies, asthmas, Type 1 diabetes, and eczema. All of these conditions have increased as breastfeeding has declined.

It is perfectly true that many cases of subnormal energy can be helped by the proper glandular dosage, but how many of those who have spoken to you of being probably hypo-thyroid* ever went through the simple process of having a basal metabolism test to see if that were really the trouble? Of course they can claim that the situation is so grave that they cannot even get up energy to start being cured; there’s no answer to that one. But if you are really seriously handicapped by lethargy, you can take your first successward step by consulting a good diagnostician, if necessary. If necessary, mind; for there is a fact which makes a good deal of the talk about glandular insufficiency look like the alibi it too often is, and which will be confirmed for you by specialists in glandular therapy if you ask them: that if those who complain of lethargy increase their habitual activity little by little the glands respond by increased secretion. In short, very often this condition can be cured by starting at the other end! You may rest assured that you will have no consequent breakdown in following this advice unless you deliberately (and with intent to cripple yourself) leap from a practically comatose state to one of manic activity.

Grief becomes problematic when the conditions needed to help us work with grief are absent. For example, when we are forced to carry our sorrow in isolation, or when the time needed to fully metabolize the nutrients of a particular loss is denied, and we are pressured to return to “normal” too soon.

Supplements may hinder autophagy. When fasting for metabolic reasons (meaning insulin resistance–related conditions such as type 2 diabetes, obesity, PCOS, and nonalcoholic fatty liver disease), the effectiveness of supplements is questionable. Most vitamins are fat soluble, but if you’re not taking in fat they won’t be as effective. Probiotics are fine to continue taking while fasting.

For the most part, grief is not a problem to be solved, not a condition to be medicated, but a deep encounter with an essential experience of being human. Grief becomes problematic when the conditions needed to help us work with grief are absent. For example, when we are forced to carry our sorrow in isolation, or when the time needed to fully metabolize the nutrients of a particular loss is denied, and we are pressured to return to “normal” too soon. We are told to “get on with it” and “get over it.” The lack of courtesy and compassion surrounding grief is astonishing, reflecting an underlying fear and mistrust of this basic human experience

Myoclonic seizures are brief shock-like jerks of a muscle or group of muscles. They occur in a variety of epilepsy syndromes that have different characteristics. Epilepsy can experience myoclonus in hiccups or in a sudden jerk that may wake you up as you’re just falling asleep. Myoclonus refers to a quick, involuntary muscle jerk. Myoclonus may occur because of a nervous system (neurological) disorder, such as epilepsy, a metabolic condition, or a reaction to a medication. Myoclonic epilepsy are caused by abnormal electrical activity in the brain, which triggers the myoclonic muscle movements. The cause of myoclonus is corrected if possible. For example, drugs that can cause myoclonus are stopped. A high or low blood sugar level is corrected, and kidney failure is treated with hemodialysis. If the cause cannot be corrected, certain ant seizure drugs (such as valproate and levetiracetam) or clonazepam (a mild sedative) may lessen symptoms. Asian Neuro Centre is one of the largest and most experienced practices in Indore where the best & experienced neurologist is skilled in dozens of specialties, working to ensure quality care and successful recovery.

One quick note: diabetes ranks as only the seventh or eighth leading cause of death in the United States, behind things like kidney disease, accidents, and Alzheimer’s disease. In 2020, a little more than one hundred thousand deaths were attributed to type 2 diabetes, a fraction of the number due to either cardiovascular disease or cancer. By the numbers, it barely qualifies as a Horseman. But I believe that the actual death toll due to type 2 diabetes is much greater and that we undercount its true impact. Patients with diabetes have a much greater risk of cardiovascular disease, as well as cancer and Alzheimer’s disease and other dementias; one could argue that diabetes with related metabolic dysfunction is one thing that all these conditions have in common.

Fructose isn’t the only thing that creates uric acid; foods high in chemicals called purines, such as certain meats, cheeses, anchovies, and beer, also generate uric acid. This is why gout, a condition of excess uric acid, was so common among gluttonous aristocrats in the olden days (and still today). I test my patients’ levels of uric acid, not only because high levels may promote fat storage but also because it is linked to high blood pressure. High uric acid is an early warning sign that we need to address a patient’s metabolic health, their diet, or both.

No longer to accept anything at all, no longer to take anything, no longer to absorb anything—to cease reacting altogether. This fatalism…can preserve life under the most perilous conditions by reducing the metabolism, slowing it down, as a kind of will to hibernate.

[C]apitalism is not a natural and inevitable consequence of human nature, or of the age-old social tendency to 'truck, barter, and exchange' It is a late and localized product of very specific historical conditions. The expansionary drive of capitalism, reaching a point of virtual universality today, is not the consequence of its conformity to human nature or to some transhistorical law, or of some racial or cultural superiority of 'the West', but the product of its own historically specific internal laws of motion, its unique capacity as well as its unique need for constant self-expansion. Those laws of motion required vast social transformations and upheavals to set them in train. They required a transformation in the human metabolism with nature, in the provision of life's basic necessities. Second, capitalism has, from the beginning, been a deeply contradictory force. The very least that can be said is that the capitalist system's unique capacity, and need, for self-sustaining growth has never been incompatible with regular stagnation and economic downturns. On the contrary, the very same logic that drives the system forward makes it inevitably susceptible to economic instabilities, which require constant 'extra-economic' interventions, if not to control them then at least to compensate for their destructive effects.

The more of these sugars we consume, and the longer we have them in our diet, the more our bodies apparently adapt by converting them to fat. Our “pattern of fructose metabolism” changes with time, as the British biochemist and fructose expert Peter Mayes says. Not only will this cause us to accumulate fat directly in the liver—a condition known as “fatty liver disease”—but it apparently causes our muscle tissue to become resistant to insulin through a kind of domino effect that is triggered by the liver cells’ resistance.

One reason I find value in the concept of metabolic syndrome is that it helps us see these disorders as part of a continuum and not a single, binary condition.

Red: Most yang, warm, and stimulating. Produces heat. Stimulates vital energy and circulation of the blood. Stimulates sensory nervous systems and energizes the five basic senses. Stimulates the healing of wounds without pus. Used in treatment of chronic infections. Too much red leads to anger and hyperactivity. Orange: Gentle yang, tonifies. Stimulates appetite, relieves cramps and spasms, increases blood pressure, induces vomiting, relieves gas, builds bones. When used with blue, regulates the endocrine system. Stimulates joy, optimism, and enthusiasm. Yellow: Yang, and the brightest of all colors. Strengthens motor nervous system and metabolism, and aids conditions of the glandular, lymphatic, and digestive systems. Stimulates intellectual functions; boosts cheerfulness and confidence. Green: Neutral yin. Slightly cooling. Treats conditions of the lungs, eyes, diabetes, musculoskeletal and inflammatory joint problems, and ulcers. Is antibacterial and aids in detoxification. Calms, soothes, and balances. Blue: Yin or cool. Relaxes body and mind, reduces fever, congestion, itching, irritation, and pain. Treats high blood pressure, burns, inflammations with pus and diseases involving heat. Contracts tissues and muscles. Calms and tranquilizes when used on the pituitary and pineal acupoints. Helpful for insomnia, phobias, and endocrine imbalances. Not indicated for depression as it is a melancholy color. Violet: Most yin color. Aids the spleen, reduces irritability, and balances the right brain. When combined with yellow, increases lymph production, controls hunger, and balances the nervous system. Acts on the unconscious.35 Complementary Colors The complementary color pairs are: red-green, orange-blue, and yellow-violet. Together, these colors balance yin and yang. For example, red might stimulate the blood and improve circulation while green calms conditions creating stress. Blue might assuage pain while orange lifts fear or depression causing tension. Yellow will strengthen the nervous system while violet calms it with a meditative state.

THE EIGHT GUIDING PRINCIPLES The eight guiding principles reveal how to detect and work with the energetic imbalances in the body. In fact, the principles consist of four polar opposites, which are as follows. INTERNAL/EXTERNAL Internal/external determines the location but not the cause of the problem. Internal organs are often affected by an emotional issue, and less frequently by an unknown cause or an external factor. External disorders are either caused by an outside-of-the-body pathogen that attacks suddenly or an acute or chronic invasion in the channel. External symptoms might involve the hair, muscles, and peripheral nerves and blood vessels, while internal systems involve the organs, deep vessels and nerves, brain, and spinal cord. HOT/COLD Hot/cold indicates the nature of the imbalance and the overall energy of the patient. Full heat or hot is excess heat in the interior. Excess heat is too much yang. Empty heat is deficient yin in the interior (usually caused by Kidney yin deficiency.) Full cold is excess cold in the interior. Excess cold comes from too much yin. Empty or deficient cold is a deficiency of yang. Hot and cold can coexist within the system. Cold symptoms might involve chills and pale skin, while hot symptoms could involve a raging fever and high metabolism. FULL/EMPTY Full/empty describes excess versus deficiency. It indicates the presence of a pathogen as well as the condition of the bodily chi. Full describes the presence of an internal or external pathogen or stagnated chi, blood, or food. Empty indicates no pathogen but weak chi, yin, yang, or blood. Mixed portrays the presence of a pathogen and weak chi, blood, yin, or yang. Full or excess symptoms often accompany a condition that is acute or sudden-onset, while empty or deficiency syndromes are more chronic and slow-moving.

THE EIGHT GUIDING PRINCIPLES The eight guiding principles reveal how to detect and work with the energetic imbalances in the body. In fact, the principles consist of four polar opposites, which are as follows. INTERNAL/EXTERNAL Internal/external determines the location but not the cause of the problem. Internal organs are often affected by an emotional issue, and less frequently by an unknown cause or an external factor. External disorders are either caused by an outside-of-the-body pathogen that attacks suddenly or an acute or chronic invasion in the channel. External symptoms might involve the hair, muscles, and peripheral nerves and blood vessels, while internal systems involve the organs, deep vessels and nerves, brain, and spinal cord. HOT/COLD Hot/cold indicates the nature of the imbalance and the overall energy of the patient. Full heat or hot is excess heat in the interior. Excess heat is too much yang. Empty heat is deficient yin in the interior (usually caused by Kidney yin deficiency.) Full cold is excess cold in the interior. Excess cold comes from too much yin. Empty or deficient cold is a deficiency of yang. Hot and cold can coexist within the system. Cold symptoms might involve chills and pale skin, while hot symptoms could involve a raging fever and high metabolism. FULL/EMPTY Full/empty describes excess versus deficiency. It indicates the presence of a pathogen as well as the condition of the bodily chi. Full describes the presence of an internal or external pathogen or stagnated chi, blood, or food. Empty indicates no pathogen but weak chi, yin, yang, or blood. Mixed portrays the presence of a pathogen and weak chi, blood, yin, or yang. Full or excess symptoms often accompany a condition that is acute or sudden-onset, while empty or deficiency syndromes are more chronic and slow-moving. CHI, BLOOD, AND FLUIDS: THE THREE UNIFYING INGREDIENTS THE FOUR LEVELS, six stages, and eight principles all revolve around the same three bodily ingredients: chi, blood, and non-blood bodily fluids. While a serious illness involves all three, many problems revolve around issues with one or another. These are the main conditions involving blood, chi, or the fluids. CHI CONDITIONS Deficient chi: Not enough chi to perform the necessary functions. Sinking or collapsed chi: The Spleen chi cannot perform its supportive functions. Stagnated chi: The chi flow is impaired. If congested or stuck in an organ, there can be pain, sluggishness, or stiffness. Rebellious chi: The chi flows in the wrong direction.

Moreover, the body is the projection screen for deadly objects stemming from primary, traumatic links with caretakers, compulsory binges and food rejection may amount to an angry response aimed at denying and attacking the body. Additionally, dysfunctional eating behaviors are often attempts to regulate extremely painful emotions, especially those that may influence an individual's narcissistic balance. This condition is shared with different forms of psychic distress, whereby an object or a behavior plays the role of regulating the "'outer" emotions in response to a lack of adequate internal resources to contend with traumatic stressors. From this perspective, EDs can be conceptualized as dysfunctional strategies of affect regulation that are connected to an impaired capability to recognize, metabolize, and mentalize affects (Lunn & Poulsen, 2012).

Moreover, the body is the projection screen for deadly objects stemming from primary, traumatic links with caretakers, compulsory binges and food rejection may amount to an angry response aimed at denying and attacking the body. Additionally. dysfunctional eating behaviors are often attempts to regulate extremely painful emotions, especially those that may influence an individual's narcissistic balance. This condition is shared with different forms of psychic distress, whereby an object or a behavior plays the role of regulating the "'outer" emotions in response to a lack of adequate internal resources to contend with traumatic stressors. From this perspective, EDs can be conceptualized as dysfunctional strategies of affect regulation that are connected to an impaired capability to recognize, metabolize, and mentalize affects (Lunn & Poulsen, 2012).

The late biologist Peter Medawar provides a compelling analogy to illustrate the fallacy. An inherited disorder called phenylketonuria (PKU) is caused by a rarely occurring abnormal gene that results in a failure to metabolize the amino acid phenylalanine in the body. As the amino acid starts accumulating in the child’s brain, he becomes profoundly retarded. The cure is simple. If you diagnose it early enough, all you do is withhold phenylalanine-containing foods from the diet and the child grows up with an entirely normal IQ. Now imagine two boundary conditions. Assume there is a planet where the gene is uncommon and phenylalanine is everywhere, like oxygen or water, and is indispensable for life. On this planet, retardation caused by PKU, and therefore variance in IQ in the population, would be entirely attributable to the PKU gene. Here you would be justified in saying that retardation was a genetic disorder or that IQ was inherited. Now consider another planet in which the converse is true: Everyone has the PKU gene but phenylalanine is rare. On this planet you would say that PKU is an environmental disorder caused by a poison called phenylalanine, and most of the variance in IQ is caused by the environment. This example shows that when the interaction between two variables is labyrinthine it is meaningless to ascribe percentage values to the contribution made by either. And if this is true for just one gene interacting with one environmental variable, the argument must hold with even greater force for something as complex and multifactorial as human intelligence, since genes interact not only with the environment but with each other.

from human studies of the Horsemen: cardiovascular and cerebrovascular disease, cancer, Alzheimer’s disease and related neurodegenerative conditions, and type 2 diabetes and related metabolic dysfunction.

I declare in faith that God's healing power is at work in my body, restoring my hormones to balance, my metabolism to function properly, and my body to its ideal weight. I believe that God is my Healer and that His power is greater than any sickness or condition. I receive His healing and restoration, and I trust that He will renew my strength and vitality. I confess that I am made whole and complete in Jesus' name, and that His grace and mercy are sufficient for me. I will walk in divine health and wholeness, and I will praise God for His goodness and love towards me." Remember to hold on to this confession with faith and patience, trusting that God's power and love are at work in your life. Keep seeking Him and His guidance, and believe that He is working for your good.

the Horsemen: cardiovascular and cerebrovascular disease, cancer, Alzheimer’s disease and related neurodegenerative conditions, and type 2 diabetes and related metabolic dysfunction.

Cutting carbs, protein, and fat to the extent that you get insufficient total calories and overall nutrition is a bad deal. Our genetics are highly averse to overexercising; the frequent depletion and fatigue is perceived to be a matter of life or death, as it was in primal times. Consequently, our appetite and reproductive hormones rage in response to the extent that we not only overeat, but also that we direct those calories to be stored as fat instead of burned. When you add to the picture the common themes of insufficient sleep and overly stressful lifestyle patterns with insufficient downtime, you have a high-stress approach that puts you at risk of total operating system failure: blowing out your thyroid, frying your adrenal glands, picking up a mysterious autoimmune illness, or landing with other world-of-hurt conditions that often escape the diagnostics of Western medicine.

talk a lot about a ketogenic diet in this book because of the miraculous health benefits it provides. This is a diet that helps shift your body’s metabolic engine from burning carbohydrates to burning fats. Interestingly, the cells of your body have the metabolic flexibility to adapt from using glucose for fuel to using ketones, which are a byproduct of breaking down fats. We will talk about this more in the cancer section of this book, but cancer cells do not have this metabolic flexibility to use fat as energy. They require glucose to thrive, which makes a ketogenic diet so effective for treating and preventing cancer.   A ketogenic diet calls for minimizing carbohydrates and replacing them with healthy fats and moderate amounts of high-quality protein. A ketogenic diet requires that roughly 50 to 70 percent of your food intake come from healthy fats, such as avocado, coconut oil, grass-fed butter, organic pasture raised eggs, and raw nuts. This diet will also help optimize your weight and prevent virtually all chronic degenerative diseases. Because you are minimizing carbs and replacing them with healthy fats, your body will shift from burning carbs as your primary fuel to burning fat.   Dr. Peter Attia, a Stanford University trained physician specializing in metabolic science, applied the ketogenic diet to his lifestyle to see what would happen. He essentially used himself as a lab rat and received incredible results. Although he was an active and fit guy, he always had a tendency toward metabolic syndrome. Metabolic syndrome is a cluster of conditions – increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels – that occur together, increasing your risk of heart disease, stroke, and diabetes. He decided to experiment with the ketogenic diet and see if it could improve his overall health status.

When you add to the picture the common themes of insufficient sleep and overly stressful lifestyle patterns with insufficient downtime, you have a high-stress approach that puts you at risk of total operating system failure: blowing out your thyroid, frying your adrenal glands, picking up a mysterious autoimmune illness, or landing with other world-of-hurt conditions that often escape the diagnostics of Western medicine.

To quote Gary Taubes, “In fact, we can define this mild ketosis as the normal state of human metabolism when we’re not eating the carbohydrates that didn’t exist in our diets for 99.9 percent of human history. As such, ketosis is arguably not just a natural condition but even a particularly healthful one.”28

For every diabetic, there are three or four people with prediabetes (encompassing the conditions impaired fasting glucose, impaired glucose tolerance, and metabolic syndrome)

This hypothesis of eating behavior did away with set points and lipostats and relied instead on the physiological notion of hunger as a response to the availability of internal fuels and to the hormonal mechanisms of fuel partitioning. Hunger and satiety are manifestations of metabolic needs and physiological conditions at the cellular level, and so they’re driven by the body, no matter how much we like to think it’s our brains that are in control.

Considering the time necessary for the effects to show up, we, by analogy with other physiological literature, have observed “conditioning” improvements after a very short training period (1-2 weeks). These short-term changes are rather due to a better neuromuscular and vascular control (a more efficient metabolism, blood flow distribution and use of muscle fibers) than to changes in the muscle structure and will therefore be lost quickly with inactivity. Stable or longer lasting adaptations involve the remodeling of the muscle, such as the enhancement of the mitochondria content or an increase of capillaries, and require, therefore, much longer and continuous training periods.

The basis for the potential of all virolytic therapeutics resides in the exquisite selectivity they exhibit for infecting and killing cancer cells. The very nature of cancer cells makes them extremely susceptible to virus infection: they divide in an uncontrolled fashion and are metabolically hyperactive, thus they exhibit greatly diminished capacity for apoptosis and innate immune defense against virus infection. While normal cells reduce metabolic activity, activate apoptotic signaling pathways, and block cell cycle progression in response to virus infection, cancer cells remain oblivious. These are perfect conditions for the growth of viruses, particularly those that are attenuated for growth in normal cells. Consequently, oncolytic viruses are specific reagents that target cancer cells and spread from cell to cell within tumors. It has become apparent that the direct lytic effects of viruses on cancer cells is just one element of their therapeutic effects, the cytolisis of infected cells releases viral and cellular antigens that can provoke anti-tumor immune responses, and some cancer therapeutic viruses are engineered to deliver additional genes such as immune activators to augment these effects.

When you deprive your body of the minimum alkaline needs and your body continues to produce metabolic acids, it leads to a build-up of these acids in your body. This condition is known as chronic low-grade metabolic acidosis. Acidosis hardens your arteries, weakens your bones and kidneys, spoils your skin and affects your well-being.

Metabolic networks remain the only class of biological network reconstructed reasonably comprehensively at the genome-scale in humans. Given that metabolic networks are ultimately based on directed chemical reactions that obey the laws of mass and energy balance, they can further serve the basis for calculations to predict reaction rates (metabolic flux). These fluxes can subsequently be used to compute productions and growth rates of metabolites. In flux balance analysis, the set of reactions is formulated as a stochiometric matrix, which enumerates the ratios of metabolite participation in each reaction. A set of physically possible reaction flux rates result by enforcing a steady-state mass balance (homeostasis) and additional constraints on reaction reversabilities and maximal conversion rates. From within the space of chemically feasible reaction flux combinations, the subset of biologically relevant reaction flux profiles can be solved by optimizing an objective function. The most commonly used objective function in microbes has been to maximize the production of biomass, which serves as a proxy for maximizing growth rate. Notably, while maximal growth may be an appropriate assumption for diseases such as cancer under certain conditions, the best cellular objective function to simulate many human tissues and cell types is unknown (and is likely condition-specific). Adjusting this objective function, which was developed based on microbial physiology, to better reflect human tissues is an area of active research.

Does being “thin” ensure optimal “health”? No. It’s now well accepted that many lean individuals have the condition known as metabolic syndrome, which is a step along the progression from health to heart disease, diabetes, cancer, and possibly Alzheimer’s disease as well. The likely scenario is that these individuals, despite being lean, have what’s called visceral fat—fat around the organs, and particularly the liver—and that this is exacerbating or causing the metabolic syndrome. The argument I’m making is that this visceral fat, too, is caused by the quality and quantity of the carbohydrates in the diet.   8.

All about Yoga Beauty Health.Yoga is a gathering of physical, mental, and otherworldly practices or teaches which started in antiquated India. There is a wide assortment of Yoga schools, practices, and objectives in Hinduism, Buddhism, and Jainism. Among the most surely understood sorts of yoga are Hatha yoga and Rāja yoga. The birthplaces of yoga have been theorized to go back to pre-Vedic Indian conventions; it is said in the Rigveda however in all probability created around the 6th and fifth hundreds of years BCE,in antiquated India's parsimonious and śramaṇa developments. The order of most punctual writings depicting yoga-practices is indistinct, varyingly credited to Hindu Upanishads. The Yoga Sutras of Patanjali date from the main portion of the first thousand years CE, however just picked up noticeable quality in the West in the twentieth century. Hatha yoga writings risen around the eleventh century with sources in tantra Yoga masters from India later acquainted yoga with the west after the accomplishment of Swami Vivekananda in the late nineteenth and mid twentieth century. In the 1980s, yoga wound up noticeably well known as an arrangement of physical exercise over the Western world.Yoga in Indian conventions, be that as it may, is more than physical exercise; it has a reflective and otherworldly center. One of the six noteworthy standard schools of Hinduism is likewise called Yoga, which has its own epistemology and transcendentalism, and is firmly identified with Hindu Samkhya reasoning. Beauty is a normal for a creature, thought, protest, individual or place that gives a perceptual ordeal of delight or fulfillment. Magnificence is examined as a major aspect of style, culture, social brain research, theory and human science. A "perfect delight" is an element which is respected, or has includes broadly ascribed to excellence in a specific culture, for flawlessness. Grotesqueness is thought to be the inverse of excellence. The experience of "magnificence" regularly includes a translation of some substance as being in adjust and amicability with nature, which may prompt sentiments of fascination and passionate prosperity. Since this can be a subjective ordeal, it is frequently said that "excellence is entirely subjective. Health is the level of practical and metabolic proficiency of a living being. In people it is the capacity of people or groups to adjust and self-oversee when confronting physical, mental, mental and social changes with condition. The World Health Organization (WHO) characterized wellbeing in its more extensive sense in its 1948 constitution as "a condition of finish physical, mental, and social prosperity and not simply the nonappearance of sickness or ailment. This definition has been liable to contention, specifically as lacking operational esteem, the uncertainty in creating durable wellbeing procedures, and on account of the issue made by utilization of "finish". Different definitions have been proposed, among which a current definition that associates wellbeing and individual fulfillment. Order frameworks, for example, the WHO Family of International Classifications, including the International Classification of Functioning, Disability and Health (ICF) and the International Classification of Diseases (ICD), are usually used to characterize and measure the parts of wellbeing. yogabeautyhealth.com

all life forms, no matter how diverse, have common characteristics: 1) they are made up of cells, enclosed by a membrane that maintains internal conditions different from their surroundings, 2) they contain DNA or RNA as the material that carries their master plan, and 3) they carry out a process, called metabolism, which involves the conversion of different forms of energy by means of which they sustain themselves.

The medical research community came to recognize that insulin resistance and a condition now known as “metabolic syndrome” is a major, if not the major, risk factor for heart disease and diabetes. Before we get either heart disease or diabetes, we first manifest metabolic syndrome. The CDC now estimates that some seventy-five million adult Americans have metabolic syndrome. The very first symptom or diagnostic criterion that doctors are told to look for in diagnosing metabolic syndrome is an expanding waistline. This means that if you’re overweight or obese—as two-thirds of American adults are—there’s a good chance that you have metabolic syndrome; it also means that your blood pressure is likely to be elevated, and you’re glucose-intolerant and thus on the way to becoming diabetic. This is why you’re more likely to have a heart attack than a lean individual—although lean individuals can also have metabolic syndrome, and those who do are more likely to have heart disease and diabetes than lean individuals without it. Metabolic syndrome ties together a host of disorders that the medical community typically thought of as unrelated, or at least having separate and distinct causes—getting fatter (obesity), high blood pressure (hypertension), high triglycerides, low HDL cholesterol (dyslipidemia), heart disease (atherosclerosis), high blood sugar (diabetes), and inflammation (pick your disease)—as products of insulin resistance and high circulating insulin levels (hyperinsulinemia). It’s a kind of homeostatic disruption in which regulatory systems throughout the body are misbehaving with slow, chronic, pathological consequences everywhere.

Metabolic syndrome changes the vocabulary that physicians use when they discuss a patient’s risk of heart disease. High cholesterol isn’t among the cluster of metabolic abnormalities, nor is elevated LDL cholesterol, the “bad” cholesterol. Rather, the key factors are high triglycerides, low HDL cholesterol, high blood pressure, overweight, glucose intolerance, and, more than anything, the condition of being insulin-resistant and thus oversecreting insulin, day in and day out. All of these abnormalities happen to be related to the carbohydrate content of the diet, not to the fat content.

Raj’s Story Part One: Chilling with the Family “Has he had his medication?” I turned to face the guest who was currently staying with us, dumbstruck by his egregious statement. On the other side of the room my younger brother and father were arguing as he didn’t want my dad to comb his hair. His words took a moment to sink in and then I felt a cold rage as I realised that he thought my younger brother took his medications to control his behaviour. He didn’t realise that they were there to support his metabolic genetic condition Cystinosis and thus made a stereotypical and callous deduction. He didn’t realise that the medications were the only thing keeping my brother’s health from deteriorating and allowing him the energy to actually have an argument in the first place. He didn’t realise how close I was to snapping,

The medical name for this condition is Non-Alcoholic Fatty Liver Disease (NAFLD) and it describes a range of conditions in which the liver tests are abnormal in people who drink little or no alcohol. It ranges from a mild condition in which excess fat is deposited in the liver causing slightly abnormal liver tests to a more serious condition in which the fat in the liver leads to inflammation, scarring and cirrhosis, which is irreversible liver damage. NAFLD is very common and may be found in up to 1 in 5 adults. Of those with NAFLD, about 1 in 4 will develop the more serious form leading to cirrhosis. This is a very slow process and may progress over years to liver failure. It is related to obesity and as in the metabolic syndrome (see previous question) insulin resistance is the underlying cause. There

These increases in brain cholesterol and pituitary activity were clues that were rich in their implications, and in the late 1960’s a research team at the University of California at Berkeley began to look for specific differences in the neural structures of gentled and ungentled rats. They found that greater tactile stimulation resulted in the following differences: These animals’ brains were heavier, and in particular they had heavier and thicker cerebral cortexes. This heaviness was not due only to the presence of more cholesterol—that is, more myeline sheaths—but also to the fact that actual neural cell bodies and nuclei were larger. Associated with these larger cells were greater quantities of cholinesterase and acetylcholinesterase, two enzymes that support the chemical activities of nerve cells, and also a higher ratio of RNA to DNA within the cells. Increased amounts of these specific compounds indicates higher metabolic activity. Measurements of the synaptic junctions connecting nerve cells revealed that these junctions were 50% larger in cross-section in the gentled rats than in the isolated ones. The gentled rats’ adrenal glands were also markedly heavier, evidence that the pituitary-adrenal axis—the most important monitor of the body’s hormonal secretions—was indeed more active.34 Many other studies have confirmed and added to these findings. Laboratory animals who are given rich tactile experience in their infancy grow faster, have heavier brains, more highly developed myelin sheaths, bigger nerve cells, more advanced skeletal muscular growth, better coordination, better immunological resistance, more developed pituitary/adrenal activity, earlier puberties, and more active sex lives than their isolated genetic counterparts. Associated with these physiological advantages are a host of emotional and behavioral responses which indicate a stronger and much more successfully adapted organism. The gentled rats are much calmer and less excitable, yet they tend to be more dominant in social and sexual situations. They are more lively, more curious, more active problem solvers. They are more willing to explore new environments (ungentled animals usually withdraw fearfully from novel situations), and advance more quickly in all forms of conditioned learning exercises.35 Moreover, these felicitous changes are not to be observed only in infancy and early maturation; an enriched environment will produce exactly the same increases in brain and adrenal weights and the same behavioral changes in adult animals as well, even though the adults require a longer period of stimulation to show the maximum effect.36

I also discovered I had Polycystic Ovary Syndrome, or PCOS, a hormonal condition that can affect metabolism, fertility, and other reproductive dynamics.

Fatigue treatment/energy enhancement—For this purpose, we want to boost overall mitochondrial health, decrease inflammation in the blood, enhance immune function, optimize hormones, and decrease brain inflammation. First, take of all your clothes and shine it diffusely on your entire body for 30-60 seconds (from 24”-36” away), back and front from head to toe, to wake up every cell in your body. 1-2 minutes shining it on the neck and thyroid gland area and thymus area in the center of the chest, from roughly 6-12” away. There are studies already showing this can impact thyroid function (the studies were done in people with Hashimoto’s hypothyroidism), which is critical to metabolic health in the entire body. The light on the thymus can potentially enhance immune function. 1-2 minutes on your sex organs (from 6-12” away) if possible, as this will increase the health of those tissues and promote optimal hormonal function. 1-2 minutes on your belly (from 6-12” away) to get systemic effects through getting the red/NIR light in the entire blood of your body. (Remember, some research has shown systemic effects, likely from irradiating the blood and affecting blood cells, inflammatory cytokines, and immune cells.) 1-3 minutes on your forehead/brain (from 6-12” away) and another 1-3 minutes on the base of the neck and spine area to decrease brain inflammation and support mitochondrial health in the brain. Total treatment time should be no more than 10-12 minutes. Also, be aware that if you have severe fatigue (e.g. Chronic Fatigue Syndrome) or are very ill with a particular condition, you may need to cut these doses in half or even do only 1/4th or 1/5th of these recommendations to start. Remember that the more unwell you are, the smaller doses you should use, especially starting out.

In a passage of the third volume of Capital7, Marx very aptly describes the material side of social life, and especially its economic side, that of production and consumption, as an extension of human metabolism, i.e. of man’s exchange of matter with nature. He clearly states that our freedom must always be limited by the necessities of this metabolism. All that can be achieved in the direction of making us more free, he says, is ‘to conduct this metabolism rationally, … with a minimum expenditure of energy and under conditions most dignified and adequate to human nature. Yet it will still remain the kingdom of necessity. Only outside and beyond it can that development of human faculties begin which constitutes an end in itself—the true kingdom of freedom. But this can flourish only on the ground occupied by the kingdom of necessity, which remains its basis …’ Immediately before this, Marx says: ‘The kingdom of freedom actually begins only where drudgery, enforced by hardship and by external purposes, ends; it thus lies, quite naturally, beyond the sphere of proper material production.’ And he ends the whole passage by drawing a practical conclusion which clearly shows that it was his sole aim to open the way into that non-materialist kingdom of freedom for all men alike: ‘The shortening of the labour day is the fundamental pre-requisite.’ In my opinion this passage leaves no doubt regarding what I have called the dualism of Marx’s practical view of life. With Hegel he thinks that freedom is the aim of historical development. With Hegel he identifies the realm of freedom with that of man’s mental life. But he recognizes that we are not purely spiritual beings; that we are not fully free, nor capable of ever achieving full freedom, unable as we shall always be to emancipate ourselves entirely from the necessities of our metabolism, and thus from productive toil. All we can achieve is to improve upon the exhausting and undignified conditions of labour, to make them more worthy of man, to equalize them, and to reduce drudgery to such an extent that all of us can be free for some part of our lives. This, I believe, is the central idea of Marx’s ‘view of life’; central also in so far as it seems to me to be the most influential of his doctrines.

But when the conditions are more subtle, things like office politics, opportunism, occasional rounds of layoffs and a general lack of trust among colleagues, we adapt. Like being at base camp on Everest, we believe that we are fine and can cope. However, the fact remains that the human animal is not built for these conditions. Even though we may think we’re comfortable, the effects of the environment still take their toll. Just because we become accustomed, just because it becomes normal, doesn’t mean it’s acceptable. On Everest, even after we’ve adapted, if we spend too long on the mountain, our internal organs start to break down. In an unhealthy culture, it’s the same. Even though we can get used to living with stress and low, regular levels of cortisol in our bodies, that doesn’t mean we should. A constant flow of cortisol isn’t just bad for organizations. It can also do serious damage to our health. Like the other selfish chemicals, cortisol can help us survive, but it isn’t supposed to be in our system all the time. It wreaks havoc with our glucose metabolism. It also increases blood pressure and inflammatory responses and impairs cognitive ability. (It’s harder to concentrate on things outside the organization if we are stressed about what’s going on inside.) Cortisol increases aggression, suppresses our sex drive and generally leaves us feeling stressed out. And here’s the killer—literally. Cortisol prepares our bodies to react suddenly—to fight or run as circumstances demand. Because this takes a lot of energy, when we feel threatened, our bodies turn off nonessential functions, such as digestion and growth. Once the stress has passed, these systems are turned on again. Unfortunately, the immune system is one of the functions that the body deems nonessential, so it shuts down during cortisol bursts. In other words, if we work in environments in which trust is low, relationships are weak or transactional and stress and anxiety are normal, we become much more vulnerable to illness.

Other Childhood Metabolic Conditions Epidemic levels of obesity, liver dysfunction, and brain dysfunction demonstrate a cellular energy epidemic. And our children’s small, not fully developed bodies are being set up to fail at an early age because our culture and daily lives have been co-opted by processed foods and the other factors that damage mitochondria and cellular energy production.

But the medicalization of chronic disease in the past fifty years has been an abject failure. Today, we’ve siloed diseases and have a treatment for everything: High cholesterol? See a cardiologist for a statin. High fasting glucose? See an endocrinologist for metformin. ADHD? See a neurologist for Adderall. Depressed? See a psychiatrist for a selective serotonin reuptake inhibitor (SSRI). Can’t sleep? See a sleep specialist for Ambien. Pain? See a pain specialist for an opioid. PCOS? See an OB-GYN for clomiphene. Erectile dysfunction? See a urologist for Viagra. Overweight? See an obesity specialist for Wegovy. Sinus infections? See an ENT for an antibiotic or surgery. But what nobody talks about—what I think many doctors don’t even realize—is that the rates of all these conditions are going up at the exact time we are spending trillions of dollars to “treat them.

The truth: we should consider listening to the medical system if we have an acute issue like a life-threatening infection or broken bone. But when it comes to the chronic conditions that plague our lives, we should question almost every institution regarding nutrition or chronic disease advice. All you need to do is follow the money and incentives.

Authors and poets who address the human condition, mortality, eternity, and continuity with nature that I recommend are Mary Oliver, Pema Chödrön, Paramahansa Yogananda, Michael Pollan, Clarissa Pinkola Estés, Seneca, Marcus Aurelius, Robin Wall Kimmerer, Rumi, Lao-tzu, Khalil Gibran, Hafiz, Walt Whitman, W. S. Merwin, Thích Nhất Hạnh, Diane Ackerman, Alan Watts, Lewis Thomas, Ram Das, Rainer Maria Rilke, Deepak Chopra, and Wang Wei.

Migraine, like my patient Sarah had, also correlates closely to poor metabolic health. In the ENT otology clinic, we often saw this condition and had limited success in treating it. Sufferers of this debilitating neurological disease—about 12 percent of people in the United States—tend to have higher insulin levels and insulin resistance. A comprehensive review of fifty-six research articles identified links between migraine and poor metabolic health, pointing out that “migraine sufferers tend to have impaired insulin sensitivity.” The review supports the “neuro-energetic” theory of migraine. Additionally, evidence suggests that micronutrient deficiencies in key mitochondrial cofactors may also be a contributing factor of migraine. Research has suggested that migraines could be treated by restoring levels of vitamins B and D, magnesium, CoQ10, alpha lipoic acid, and L-carnitine. Vitamin B12, for instance, is involved in the electron transport chain responsible for the final steps of ATP generation in the mitochondria, and studies have indicated that high doses of B12 can help prevent migraine. These micronutrients usually have fewer side effects than other drugs used to treat migraines, making them a promising option for relief, which can be obtained through a diet rich in these micronutrients, or supplementation. Having high markers of oxidative stress, a key Bad Energy feature, is associated with a significantly higher risk of migraine in women, with some studies suggesting that migraine attacks are a symptomatic response to increased levels of oxidative stress. Less painful and more common tension-type headaches are also linked to high variability (excess peaks and crashes) in blood sugar. Hearing Loss The same story of metabolic ignorance in the ENT department unfolded for auditory problems and hearing loss, one of the most common issues presented to our ENT clinic. We’d typically tell our patients that their auditory decline was inevitable, due to aging and loud concerts in their youth, and we would suggest interventions like hearing aids. Yet insulin resistance is a little-known link to hearing problems. If you have insulin resistance, you are more likely to lose hearing as you age because of poor energy production in the delicate hearing cells and blockage of the small blood vessels that supply the inner ear. One study showed that insulin resistance is associated with age-related hearing loss, even when controlling for weight and age. The likely mechanism for this is that the auditory system requires high energy utilization for its complex signal processing. In the case of insulin resistance, glucose metabolism is disturbed, leading to decreased energy generation. The impact of Bad Energy on hearing is not subtle: A study showed that the prevalence of high-frequency hearing impairment among subjects with elevated fasting glucose levels was 42 percent compared to 24 percent in those with normal fasting glucose. Moreover, insulin resistance is associated with high-frequency mild hearing impairment in the male population under seventy years of age, even before the onset of diabetes. These papers suggest that assessing early metabolic function and levels of insulin resistance is essential in the ENT clinic and counseling individuals on the potential warning signs is paramount.