Laboratory Motivational Quotes

Always this same morbid interest in other people and their doings, their privacies, their dirty linen, always this air of alertness for personal happenings, personalities, personalities, personalities. Always this subtle criticism and appraisal of other people, this analysis of other people’s motives. If anatomy presupposes a corpse, then psychology presupposes a world of corpses. Personalities, which means personal criticism and analysis, presuppose a whole world laboratory of human psyches waiting to be vivisected. If you cut a thing up, of course it will smell. Hence, nothing raises such an infernal stink, at last, as human psychology.

I don't like museums, I like labs.

An invention is a responsibility of the individual, society cannot invent, it can only applaud the invention and inventor.

As respects its isolation and its indifference to the basic requirements of all organic activity, the pecuniary power complex discloses a startling resemblance to a newly discovered center in the brain-that which is called the pleasure center. So far as is known, this pleasure center performs no useful function in the organism, unless it should prove that in some still obscure way it plays a part in more functional pleasure reactions. But in laboratory monkeys this localized center can be penetrated by electrodes which permit a micro-current to stimulate the nervous tissue in such a fashion that the flow of current-and hence the intensity of pleasure-can be regulated by the animal himself. Apparently the stimulation of this pleasure center is so rewarding that the animal will continue to press the current regulator for an indefinite length of time, regardless of every other impulse or physiological need, even that for food, and even to the point of starvation. The intensity of this abstract stimulus produces something like a total neurotic insensibility to life needs. The power complex seems to operate on the same principle. The magical electronic stimulus is money. What increases the resemblance between this pecuniary motivation and that of the cerebral pleasure center is that both centers, unlike virtually all organic reactions, recognize no quantitative limits. What has always been true of money, among those susceptible to its influence, applies equally to the other components of the power complex: the abstraction replaces the concrete reality, and therefore those who seek to increase it never know when they have had enough. Each of these drives, for power, for goods, for fame, for pleasure, may-it goes without saying-have as useful a part to play in the normal economy of a community as in the human body itself. It is by their detachment, their isolation, their quantitative over-concentration, and their mutual re-enforcement that they become perverse and life-corroding.

WHY ADDICTION IS NOT A DISEASE In its present-day form, the disease model of addiction asserts that addiction is a chronic, relapsing brain disease. This disease is evidenced by changes in the brain, especially alterations in the striatum, brought about by the repeated uptake of dopamine in response to drugs and other substances. But it’s also shown by changes in the prefrontal cortex, where regions responsible for cognitive control become partially disconnected from the striatum and sometimes lose a portion of their synapses as the addiction progresses. These are big changes. They can’t be brushed aside. And the disease model is the only coherent model of addiction that actually pays attention to the brain changes reported by hundreds of labs in thousands of scientific articles. It certainly explains the neurobiology of addiction better than the “choice” model and other contenders. It may also have some real clinical utility. It makes sense of the helplessness addicts feel and encourages them to expiate their guilt and shame, by validating their belief that they are unable to get better by themselves. And it seems to account for the incredible persistence of addiction, its proneness to relapse. It even demonstrates why “choice” cannot be the whole answer, because choice is governed by motivation, which is governed by dopamine, and the dopamine system is presumably diseased. Then why should we reject the disease model? The main reason is this: Every experience that is repeated enough times because of its motivational appeal will change the wiring of the striatum (and related regions) while adjusting the flow and uptake of dopamine. Yet we wouldn’t want to call the excitement we feel when visiting Paris, meeting a lover, or cheering for our favourite team a disease. Each rewarding experience builds its own network of synapses in and around the striatum (and OFC), and those networks continue to draw dopamine from its reservoir in the midbrain. That’s true of Paris, romance, football, and heroin. As we anticipate and live through these experiences, each network of synapses is strengthened and refined, so the uptake of dopamine gets more selective as rewards are identified and habits established. Prefrontal control is not usually studied when it comes to travel arrangements and football, but we know from the laboratory and from real life that attractive goals frequently override self-restraint. We know that ego fatigue and now appeal, both natural processes, reduce coordination between prefrontal control systems and the motivational core of the brain (as I’ve called it). So even though addictive habits can be more deeply entrenched than many other habits, there is no clear dividing line between addiction and the repeated pursuit of other attractive goals, either in experience or in brain function. London just doesn’t do it for you anymore. It’s got to be Paris. Good food, sex, music . . . they no longer turn your crank. But cocaine sure does.

INTRODUCTION The Puzzling Puzzles of Harry Harlow and Edward Deci In the middle of the last century, two young scientists conducted experiments that should have changed the world—but did not. Harry F. Harlow was a professor of psychology at the University of Wisconsin who, in the 1940s, established one of the world’s first laboratories for studying primate behavior. One day in 1949, Harlow and two colleagues gathered eight rhesus monkeys for a two-week experiment on learning. The researchers devised a simple mechanical puzzle like the one pictured on the next page. Solving it required three steps: pull out the vertical pin, undo the hook, and lift the hinged cover. Pretty easy for you and me, far more challenging for a thirteen-pound

With the exception of a few supporters at Bell Laboratories who understood digital technology, AT&T continued to resist the idea. The most outspoken skeptics were some of AT&T’s most senior technical people. “After I heard the melodic refrain of ‘bullshit’ often enough,” Baran recalled, “I was motivated to go away and write a series of detailed memoranda papers, to show, for example, that algorithms were possible that allowed a short message to contain all the information it needed to find its own way through the network.” With each objection answered, another was raised and another piece of a report had to be written. By the time Baran had answered all of the concerns raised by the defense, communications, and computer science communities, nearly four years had passed and his volumes numbered eleven.

In game theory, as in applications of other technologies that use RPT [Revealed Preference Theory], the purpose of the machinery is to tell us what happens when patterns of behavior instantiate some particular strategic vector, payoff matrix, and distribution of information—for example, a PD [Prisoner's Dilemma]—that we’re empirically motivated to regard as a correct model of a target situation. The motivational history that produced this vector in a given case is irrelevant to which game is instantiated, or to the location of its equilibrium or equilibria. As Binmore (1994, pp. 95–256) emphasizes at length, if, in the case of any putative PD, there is any available story that would rationalize cooperation by either player, then it follows as a matter of logic that the modeler has assigned at least one of them the wrong utility function (or has mistakenly assumed perfect information, or has failed to detect a commitment action) and so made a mistake in taking their game as an instance of the (one-shot) PD. Perhaps she has not observed enough of their behavior to have inferred an accurate model of the agents they instantiate. The game theorist’s solution algorithms, in themselves, are not empirical hypotheses about anything. Applications of them will be only as good, for purposes of either normative strategic advice or empirical explanation, as the empirical model of the players constructed from the intentional stance is accurate. It is a much-cited fact from the experimental economics literature that when people are brought into laboratories and set into situations contrived to induce PDs, substantial numbers cooperate. What follows from this, by proper use of RPT, not in discredit of it, is that the experimental setup has failed to induce a PD after all. The players’ behavior indicates that their preferences have been misrepresented in the specification of their game as a PD. A game is a mathematical representation of a situation, and the operation of solving a game is an exercise in deductive reasoning. Like any deductive argument, it adds no new empirical information not already contained in the premises. However, it can be of explanatory value in revealing structural relations among facts that we otherwise might not have noticed.

Andy’s lips three days later, as he, Alden, the King, and Mermin met in the laboratory. “Do you now?” Mermin raised an eyebrow. “Have you discovered that servant’s motive yet?” Andy asked. “So far it remains unclear.” The King held up a hand. “Until we know why he tried to poison Alden, we won’t know what action to take.

How an Outsider Becomes an Insider Here's a letter I got from my Platinum Member, Jerry Jones, president of a direct marketing and coaching company providing services to dentists nationwide: “Back in 1997, after about two months of owning this business, I read the ‘10 Smart Questions’ in this chapter. The list exposed my biggest handicap in marketing to dentists: not being one of them. Because I'm not the customer in my niche, I have had to work hard at understanding what motivates them, keeps them awake at night, what the current desirable carrot is to them. Here are six things I do to stay in that frame of mind. And I'm apparently managing to do it, because I am frequently accused of being a dentist! I read every industry publication every month. I visit websites that host discussion forums for dentists. I subscribe to e-mail groups where only dentists communicate back and forth. I attend industry functions, conventions, seminars, and trade shows. I ‘play prospect’ with other product and service providers to dentists. I routinely ‘mastermind’ with dentists and with other marketers and vendors who provide services to the profession. I think this is so important that I even invested in three dental practices to get more firsthand understanding and to have laboratories to test my new strategies, ideas, direct-mail campaigns, and products.

Would anyone test the memory of human children by throwing them into a swimming pool to see if they remember where to get out? Yet the Morris Water Maze is a standard memory test used every day in hundreds of laboratories that make rats frantically swim in a water tank with high walls until they come upon a submerged platform that saves them. In subsequent trials, the rats need to remember the platform’s location. There is also the Columbia Obstruction Method, in which animals have to cross an electrified grid after varying periods of deprivation, so researchers can see if their drive to reach food or a mate (or for mother rats, their pups) exceeds the fear of a painful shock. Stress is, in fact, a major testing tool. Many labs keep their animals at 85 percent of typical body weight to ensure food motivation.

I have the greatest respect for conservation biologists. I care very much about conserving the rain forest and the wildlife in Indonesia, but I also found it disheartening. It often feels like you are fighting a losing battle, especially in areas where people depend so heavily on these natural resources for their own survival. After graduation, I decided to return to the original behavioral questions that motivated me. Although monogamy—both social and genetic—is rare in mammals, social monogamy is the norm in birds. Plus, birds are everywhere. I figured that if I turned my attention to studying our feathered friends, I wouldn’t have to spend months on end trying to secure research permits and travel visas from foreign governments. I wouldn’t even have to risk getting bitten by leeches (a constant problem in the Mentawais*). Birds seemed like the perfect choice for my next act. But I didn’t know anyone who studied birds. My PhD was in an anthropology department, without many links to researchers in biology departments. Serendipitously, while applying for dozens of academic jobs, I stumbled across an advertisement for a position managing Dr. Ellen Ketterson’s laboratory at Indiana University. The ad described Ketterson’s long-term project on dark-eyed juncos. Eureka! Birds! At the time, her lab primarily focused on endocrinology methods like hormone assays (a method to measure how much of a hormone is present in blood or other types of biological samples), because they were interested in how testosterone levels influenced behavior. I had no experience with either birds or hormone assays. But I had spent the last several years developing DNA sequencing and genotyping skills, which the Ketterson lab was just starting to use. I hoped that my expertise with fieldwork and genetic work would be seen as beneficial enough to excuse my lack of experience in ornithology and endocrinology. I submitted my application but heard nothing back. After a while, I did something that was a bit terrifying at the time. Of the dozens of academic positions I had applied to, this felt like the right one, so I tried harder. I wrote to Dr. Ketterson again to clarify why I was so interested in the job and why I would be a good fit, even though on paper I seemed completely wrong for it. I described why I wanted to work with birds instead of primates. I explained that I had years of fieldwork experience in challenging environments and could easily learn ornithological methods. I listed my laboratory expertise and elaborated on how beneficial it could be to her research group, and how easily I could learn to do hormone assays and why they were important for my research too. She wrote me back. I got the job.

One way to avoid the design problems encountered by the transcendental meditation researchers would be to keep one of the variables fixed. This could be either the number of meditators or the “target” of consciousness-induced order. Beyond this, as philosopher Evan Fales and sociologist Barry Markovsky of the University of Iowa suggested after reviewing the Maharishi effect, “Presumably, if the material world can be influenced in purposive ways by collective meditation, inanimate detectors could be constructed and placed at varying distances from the collective meditators.”6 This is essentially the approach that we took, although our motivations were based upon a logical extension of laboratory research on mind-matter interactions using random-number generators, and not by the claims of the transcendental meditators. Properties of Consciousness Whatever else consciousness may be, let us suppose that it also has the following properties, derived from a combination of Western and Eastern philosophies.7 The first property is that consciousness extends beyond the individual and has quantum field–like properties, in that it affects the probabilities of events. Second, consciousness injects order into systems in proportion to the “strength” of consciousness present. This is a refinement of quantum physicist Erwin Schrödinger’s observation about one of the most remarkable properties of life, namely, an “organism’s astonishing gift … of ‘drinking orderliness’ from a suitable environment.”8 Third, the strength of consciousness in an individual fluctuates from moment to moment, and is regulated by focus of attention. Some states of consciousness have higher focus than others. We propose that ordinary awareness has a fairly low focus of attention compared to peak states, mystical states, and other nonordinary states.9 Fourth, a group of individuals can be said to have “group consciousness.” Group consciousness strengthens when the group’s attention is focused on a common object or event, and this creates coherence among the group. If the group’s attention is scattered, then the group’s mental coherence is also scattered. Fifth, when individuals in a group are all attending to different things, then the group consciousness and group mental coherence is effectively zero, producing what amounts to background noise. We assume that the maximum degree of group coherence is related in some complicated way to the total number of individuals present in the group, the strength of their common focus of attention, and other psychological, physiological, and environmental factors. Sixth, physical systems of all kinds respond to a consciousness field by becoming more ordered. The stronger or more coherent a consciousness field, the more the order will be evident. Inanimate objects (like rocks) will respond to order induced by consciousness as well as animate ones (like people, or tossed dice), but it is only in the more labile systems that we have the tools to readily detect these changes in order. In sum, when a group is actively focused on a common object, the “group mind” momentarily has the “power to organize,” as Carl Jung put it.10 This leads us to a very simple idea: as the mind moves, so moves matter.

Bartal placed one rat in an enclosure, where it encountered a small transparent container, a bit like a jelly jar. Squeezed inside it was another rat, locked up, wriggling in distress. Not only did the free rat learn how to open a little door to liberate the other, but she was remarkably eager to do so. Never trained on it, she did so spontaneously. Then Bartal challenged her motivation by giving her a choice between two containers, one with chocolate chips—a favorite food that they could easily smell—and another with a trapped companion. The free rat often rescued her companion first, suggesting that reducing her distress counted more than delicious food.47 The empathy of laboratory rats has been tested by presenting them with a companion trapped in a glass container. Responding to the distress of the trapped rat, the free rat makes a purposeful effort to liberate her. This behavior disappears if the free rat is put on a relaxing drug, which dulls her sensitivity to the other’s emotional state.

He's really so adorable. The dog, I mean. Did you know he's a rescue beagle?" I'd remembered Frank and Sam had used the term the day I'd first encountered Bandit, but I'd just assumed it meant that he'd come from the pound. Rachel had set me straight. "They use them to experiment on. You know, in laboratories. Sam says they use beagles because they're so gentle and sweet-tempered they won't even bite you when you're hurting them. And after a few years when they 'retire' the dogs, some labs give them to rescue groups who try to find them homes. Sam says that Bandit didn't even know what grass was when he got him. It's his second rescue beagle. He had one before, a girl dog, but she ended up with cancer and he had to put her down. So he got Bandit." "Beagles," Sam said now, as he stood squarely on the scaffolding, "don't like to be alone. So she'll be doing me a favor." "What about the doggie day-care place?" "Nah. There's a Labradoodle there that's always picking on him. He'll be better hanging out with Rachel." I was not completely fooled. I knew he'd talked to Rachel for a while, because she'd told me that he had. "He's really nice," she'd said. "He listens." So I knew he knew that Rachel wasn't finding this an easy time, and I suspected Sam just figured she and Bandit were a lot alike in needing some companionship from somebody who understood and didn't push their boundaries. Whatever his true motivations, it was an inspired move.