Kidney Disease Quotes

Elsewhere the paper notes that vegetarians and vegans (including athletes) 'meet and exceed requirements' for protein. And, to render the whole we-should-worry-about-getting-enough-protein-and-therefore-eat-meat idea even more useless, other data suggests that excess animal protein intake is linked with osteoporosis, kidney disease, calcium stones in the urinary tract, and some cancers. Despite some persistent confusion, it is clear that vegetarians and vegans tend to have more optimal protein consumption than omnivores.

Too bad. And Mozart, not long after writing The Magic Flute, had died--in his thirties--of kidney disease. And had been buried in an unmarked pauper's grave. Thinking this, he wondered if Mozart had any intuition that the future did not exist, that he had already used up his little time. Maybe I have too, Rick thought as he watched the rehearsal move along. This rehearsal will end, the performance will end, the singers will die, eventually the last score of the music will be destroyed in one way or another; finally the name "Mozart" will vanish, the dust will have won. If not on this planet then another. We can evade it awhile. As the andys can evade me and exist a finite stretch longer. But I will get them or some other bounty hunter gets them. In a way, he realized, I'm part of the form-destroying process of entropy.

Isn`t man an amazing animal? He kills wildlife - birds, kangaroos, deer, all kinds of cats, coyotes, beavers, groundhogs, mice, foxes, and dingoes - by the millions in order to protect his domestic animals and their feed. Then he kills domestic animals by the billions and eats them. This in turn kills man by the million, because eating all those animals leads to degenerative - and fatal - health conditions like heart disease, kidney disease, and cancer. So then man tortures and kills millions more animals to look for cures for these diseases. Elsewhere, millions of other human beings are being killed by hunger and malnutrition because food they could eat is being used to fatten domestic animals. Meanwhile, some people are dying of sad laughter at the absurdity of man, who kills so easily and so violently, and once a year sends out a card praying for 'Peace on Earth.

The bottom line is this: environmental toxins are all around us, and they stimulate the production of free radicals, which can cause axidative damage to any kind of cell, be it muscle, nerve, liver, kidney,, heart, brain, and so on, and cause autoimmune disease.

Excessive consumption of the high amounts of sodium in processed, salty foods can lead to high blood pressure and heart disease, stroke, kidney damage, cancer, weight gain, osteoporosis, and overeating—this list is equally long and alarming.2

Aren’t humans amazing? They kill wildlife – birds, deer, all kinds of cats, coyotes, beavers, groundhogs, mice and foxes by the million in order to protect their domestic animals and their feed. Then they kill domestic animals by the billion and eat them. This in turn kills people by the million, because eating all those animals leads to degenerative – and fatal – health conditions like heart disease, stroke, kidney disease, and cancer. So then humans spend billions of dollars torturing and killing millions more animals to look for cures for these diseases. Elsewhere, millions of other human beings are being killed by hunger and malnutrition because food they could eat is being used to fatten domestic animals. Meanwhile, few people recognize the absurdity of humans, who kill so easily and violently, and once a year send out cards praying for “Peace on Earth.” ~Revised Preface to Old MacDonald’s Factory Farm

Bear in mind that since medications do not fix anything, they allow the underlying problem to continue uncorrected and actually accelerate. Meanwhile, new symptoms and new seemingly unrelated diseases are the inevitable consequence of this biochemical faux pas. Furthermore, drug side effects are the leading cause of death. NSAIDs as an example of only one group of medications, are fatally toxic to thousands of people each year by damaging joints, lungs, kidneys, eyes, hearts, and intestines. And they are covered by insurance. You and your doctor have been screwed into believing every symptom is a deficiency of some drug or surgery. You've been led to believe you have no control, when in truth you're the one who must take control. Unfortunately, the modus operandi in medicine is to find a drug to turn off the damaged part that is producing symptoms.

We talk about society because we want to align ourselves with a chosen group, to signal that alignment to others, and to tell a story about who we are. There are AIDS activists because there are people who want to express sympathy for gays, to align themselves against conservatives, and thereby to express “who they are”. There are no nephritis activists, because there’s no salient group you align yourself with (kidney disease sufferers?) by advocating for nephritis research, there’s no group you thereby align yourself *against*, and you don’t tell any story about what kind of person you are.

When he arrived, he found that the two most important women in his life—his mother and his young wife—were dying. At 3:00 a.m. on February 14, Valentine’s Day, Martha Roosevelt, still a vibrant, dark-haired Southern belle at forty-six, died of typhoid fever. Eleven hours later, her daughter-in-law, Alice Lee Roosevelt, who had given birth to Theodore’s first child just two days before, succumbed to Bright’s disease, a kidney disorder. That night, in his diary, Roosevelt marked the date with a large black “X” and a single anguished entry: “The light has gone out of my life.

Certainly, few of us would intentionally live our lives in a way that might cause kidney failure. Many otherwise rational people, however, find it hard to do what is best for their health rather than what they are used to doing—or what they would prefer to do.

book. Myeloma as a description has its origins with the Greek medical genius Hippocrates, who did the earliest known work on cancer, which he called karkinoma (carcinoma) because the tumors often resembled a crab, karkinos in ancient Greek. In modern descriptions, the condition is complex and treacherous: Plasma cells in the bone marrow become malignant and produce tumors, causing destruction of the bone and resulting in pathologic fracture and pain. A secretory form of the disease is characterized by the presence of Bence-Jones protein, a monoclonal immunoglobulin, which can cause anemia and kidney disease

It is not a crime to commit First Degree Writing

But I've still better things about children. I've collected a great, great deal about Russian children, Alyosha. There was a little girl of five who was hated by her father and mother, 'most worthy and respectable people, of good education and breeding.' You see, I must repeat again, it is a peculiar characteristic of many people, this love of torturing children, and children only. To all other types of humanity these torturers behave mildly and benevolently, like cultivated and humane Europeans; but they are very fond of tormenting children, even fond of children themselves in that sense. it's just their defencelessness that tempts the tormentor, just the angelic confidence of the child who has no refuge and no appeal, that sets his vile blood on fire. In every man, of course, a demon lies hidden- the demon of rage, the demon of lustful heat at the screams of the tortured victim, the demon of lawlessness let off the chain, the demon of diseases that follow on vice, gout, kidney disease, and so on. "This poor child of five was subjected to every possible torture by those cultivated parents. They beat her, thrashed her, kicked her for no reason till her body was one bruise. Then, they went to greater refinements of cruelty- shut her up all night in the cold and frost in a privy, and because she didn't ask to be taken up at night (as though a child of five sleeping its angelic, sound sleep could be trained to wake and ask), they smeared her face and filled her mouth with excrement, and it was her mother, her mother did this. And that mother could sleep, hearing the poor child's groans! Can you understand why a little creature, who can't even understand what's done to her, should beat her little aching heart with her tiny fist in the dark and the cold, and weep her meek unresentful tears to dear, kind God to protect her? Do you understand that, friend and brother, you pious and humble novice? Do you understand why this infamy must be and is permitted? Without it, I am told, man could not have existed on earth, for he could not have known good and evil. Why should he know that diabolical good and evil when it costs so much? Why, the whole world of knowledge is not worth that child's prayer to dear, kind God'! I say nothing of the sufferings of grown-up people, they have eaten the apple, damn them, and the devil take them all! But these little ones! I am making you suffer, Alyosha, you are not yourself. I'll leave off if you like

Six out of ten adults are living with a chronic illness. About 50 percent of Americans will deal with mental illness sometime in life. Seventy-four percent of adults are overweight or have obesity. Rates of cancer, heart disease, kidney disease, upper respiratory infections, and autoimmune conditions are all going up at the exact time we are spending more and more to treat them. In the face of these trends, American life expectancy has been declining for the most sustained period since 1860.

Health outcomes for black people are worse across the board during non-pandemic times. Black women are 22% more likely to die from heart disease than white women and 71% more likely to die from cervical cancer. Blacks are diagnosed with diabetes at a 71% higher rate than whites. Minorities receive lower quality care for their diabetes, resulting in more complications, such as chronic kidney disease and amputations. The list of conditions which Blacks suffer more extend to mental health, cancer, and heart disease.

The ADA takes a conservative stand, leaving out many well-documented health benefits attributable to reducing the consumption of animal products. Here are the three key sentences from the summary of their summary of the relevant scientific literature. One: Well-planned vegetarian diets are appropriate for all individuals during all stages of the life cycle, including pregnancy, lactation, infancy, childhood, and adolescence, and for athletes. TWO: Vegetarian diets tend to be lower in saturated fat and cholesterol, and have higher levels of dietary fiber, magnesium and potassium, vitamins C and E, folate, carotenoids, flavonoids, and other phytochemicals. Elsewhere the paper notes that vegetarians and vegans (including athletes) “meet and exceed requirements” for protein. And, to render the whole we-should-worry-about-getting-enough-protein-and-therefore-eat-meat idea even more useless, other data suggests that excess animal protein intake is linked with osteoporosis, kidney disease, calcium stones in the urinary tract, and some cancers.

Elsewhere the paper notes that vegetarians and vegans (including athletes) “meet and exceed requirements” for protein. And, to render the whole we-should-worry-about-getting-enough-protein-and-therefore-eat-meat idea even more useless, other data suggests that excess animal protein intake is linked with osteoporosis, kidney disease, calcium stones in the urinary tract, and some cancers. Despite some persistent confusion, it is clear that vegetarians and vegans tend to have more optimal protein consumption than omnivores.

Kidney Stones Eating a plant-based diet to alkalinize your urine may also help prevent and treat kidney stones—those hard mineral deposits that can form in your kidneys when the concentration of certain stone-forming substances in your urine becomes so high they start to crystallize. Eventually, these crystals can grow into pebble-sized rocks that block the flow of urine, causing severe pain that tends to radiate from one side of the lower back toward the groin. Kidney stones can pass naturally (and often painfully), but some become so large that they have to be removed surgically.

When Franklin D. Roosevelt signed the Social Security Act in 1935, old age was defined as sixty-five years, yet estimated life expectancy in the United States at the time was sixty-one years for males and sixty-four years for females.62 A senior citizen today, however, can expect to live eighteen to twenty years longer. The downside is that he or she also should expect to die more slowly. The two most common causes of death in 1935 America were respiratory diseases (pneumonia and influenza) and infectious diarrhea, both of which kill rapidly. In contrast, the two most common causes of death in 2007 America were heart disease and cancer (each accounted for about 25 percent of total deaths). Some heart attack victims die within minutes or hours, but most elderly people with heart disease survive for years while coping with complications such as high blood pressure, congestive heart failure, general weakness, and peripheral vascular disease. Many cancer patients also remain alive for several years following their diagnosis because of chemo-therapy, radiation, surgery, and other treatments. In addition, many of the other leading causes of death today are chronic illnesses such as asthma, Alzheimer’s, type 2 diabetes, and kidney disease, and there has been an upsurge in the occurrence of nonfatal but chronic illnesses such as osteoarthritis, gout, dementia, and hearing loss.63 Altogether, the growing prevalence of chronic illness among middle-aged and elderly individuals is contributing to a health-care crisis because the children born during the post–World War II baby boom are now entering old age, and an unprecedented percentage of them are suffering from lingering, disabling, and costly diseases. The term epidemiologists coined for this phenomenon is the “extension of morbidity.

Internal medicine doctors know the functions of the kidneys. They don’t confuse protective defenses such as cough and pain with diseases such as pneumonia and cancer. Psychiatrists lack a similar framework for the utility of stress, sleep, anxiety, and mood, so psychiatric diagnostic categories remain confusing and crude.

Some diseases, such as HIV/AIDS, have slid down the list, but among the diseases whose incidence has increased the most over the past generation is chronic kidney disease. The number of deaths has doubled.14 This has been blamed on our “meat-sweet” diet.15 Excess table sugar and high-fructose corn syrup consumption is associated with increased blood pressure and uric acid levels, both of which can damage the kidney. The saturated fat, trans fat, and cholesterol found in animal products and junk food are also associated with impaired kidney function, and meat protein increases the acid load to the kidneys, boosting ammonia production and potentially damaging our sensitive kidney cells.16 This is why a restriction of protein intake is often recommended to chronic kidney disease patients to

After years of intense research, I could come to only one conclusion: People whose diets are high in animal protein have significantly higher rates of chronic diseases: hypertension, cancer, diabetes, heart disease, and many, many others, including cataracts, diverticulitis, diverticulosis, inflammatory bowel disease, gall bladder disorders, gout, hypertension, irritable bowel syndrome, kidney stones, and rheumatoid arthritis.

Everest attempt at sixty-two, three weeks after undergoing surgery for kidney cancer, marathon des Sables six months after it was amputated fingers and toes, be measured by the diagonal of Fools four weeks after ablation of a metastasis to the lung, is this possible? Cancer does not stop your life, giving up your dreams or your goals, it is simply a parameter to manage, no more, no less than all the other parameters of life. How to ensure that the disease becomes transparent to you and your entourage, almost insignificant in terms of trip you want to accomplish? This is precisely the question that Gerard Bourrat tries to answer in this book. To make a sports performance, to live with her cancer, to live well with amputations, the path is always the same: a goal, the joy of effort, perseverance and faith. This book does not commit you to climb Everest, to run under a blazing sun, walking thousands of miles, it invites you to conquer your own Everest.

Without carbohydrates, the body will use protein and fat as fuel—this is called ketosis. When your body is in the metabolic state of ketosis, it turns fat into ketones in the liver, which will supply energy instead of glucose, as if you were fasting. You may have heard of the ketogenic diet, in fact, which focuses on protein and fat intake, while maintaining a very low carbohydrate intake. This diet, newly trendy, may have benefits such as weight loss and improved blood sugar levels. However, it is very restrictive; eliminating healthy fruits, vegetables, legumes, and other nutritious complex carbohydrates seems unnecessary and no fun. Also, we don’t know the long-term effects of ketosis (though if you do go too long without any carbs, it can lead to heart or kidney disease). What I do know, after years of studying nutrition, is that any diet that is very restrictive or eliminates entire food groups can be unrealistic and difficult to sustain. That’s why Zero Sugar Diet eliminates added sugars—but allows natural ones. Pretty sweet deal.

FOODS RICH IN ZINC Oysters, farmed, eastern, cooked, 3 medium—13 mg Alaska king crab, cooked, 1 leg—10.2 mg Beef, top sirloin, 4 oz—5.6 mg Raw, unhulled sesame seeds, 2 oz—4.4 mg Raw or roasted pumpkin seeds, 2 oz—4.2 mg Adzuki beans, cooked, 1 cup—4.1 mg Raw pine nuts, 2 oz—3.6 mg Raw cashews, 2 oz—3.2 mg Sunflower seeds, raw, 2 oz—2.8 mg Wild rice, cooked, 1 cup—2.2 mg Edamame, cooked, shelled, 1 cup—2.1 mg Black beans, kidney beans, cooked, 1 cup—1.9 mg Shiitake mushrooms, cooked, 1 cup—1.9 mg Fava beans, cooked, 1 cup—1.7 mg Broccoli, cooked, 2 cups—1.6 mg Tahini, raw, 2 tbsp—1.4 mg Kale, cooked, 2 cups—1.2 mg

MMR, polio, and varicella are live attenuated vaccines. The contaminants and excipients include human MRC5 cells, Human WI-38 lung cells, monkey kidney cells, guinea pig cell cultures and bovine serum. Live viral vaccines are all grown in human and animal cells lines and these animal and human cell lines contain human and animal retroviruses (adventitious agents which can recombine to generate new infectious retroviruses during the manufacture.) In addition to the animal and human retroviral contaminants, the carcinogen formaldehyde, antibiotics which dysregulate the GI [gastro-intestinal] and nasopharyngal microbiomes, glutamate, and bio-incompatible contaminants including nickel and chromium (EXH 6) can synergize in toxicity and the development of neuroinflammatory, neurodegenerative and neuroimmune diseases and cancer which can become clinically apparent decades later.10

1. Oral Involvement 2. Laryngeal Involvement 3. Cardiovascular Involvement 4. Skin: rashes, vitiligo, Raynaud’s 5. Constitutional symptoms: including fever, fatigue, and muscle wasting (cachexia), infections 6. Rheumatoid vasculitis and blood vessel disease 7. Lung Involvement 8. Kidney involvement 9. Eye involvement 10. Other organs: including spleen, liver, lymph system, gut KEY POINTS 1. Some symptoms and antibodies can precede diagnosis over 10 years. 2. Many studies indicate RD begins in the lungs, before joint symptoms are diagnosable. 3. RD is often called an “invisible”illness because symptoms are not obvious to casual observers. 4. Doctors must be more aware that systemic symptoms like fatigue may indicate serious problems. 5. Extra-articular disease has been proven to affect most PRD, but is still not widely recognized. 6. Acknowledging rheumatoid disease that exists beyond and before joint inflammation (arthritis) could bring a) Improved care for lower mortality b) Improved research for better treatments c) Improved diagnosis for increased remissions

The “remarkable sodium and water retaining effect of concentrated carbohydrate food,” as the University of Wisconsin endocrinologist Edward Gordon called it, was then explained physiologically in the mid-1960s by Walter Bloom, who was studying fasting as an obesity treatment at Atlanta’s Piedmont Hospital, where he was director of research. As Bloom reported in the Archives of Internal Medicine and The American Journal of Clinical Nutrition, the water lost on carbohydrate-restricted diets is caused by a reversal of the sodium retention that takes place routinely when we eat carbohydrates. Eating carbohydrates prompts the kidneys to hold on to salt, rather than excrete it. The body then retains extra water to keep the sodium concentration of the blood constant. So, rather than having water retention caused by taking in more sodium, which is what theoretically happens when we eat more salt, carbohydrates cause us to retain water by inhibiting the excretion of the sodium that is already there. Removing carbohydrates from the diet works, in effect, just like the antihypertensive drugs known as diuretics, which cause the kidneys to excrete sodium, and water along with it. This

me!” For Alexandra sitting beside him, unable to help, each cry seemed a sword thrust into the bottom of her heart. Almost worse for the Empress than the actual episodes of bleeding was the terrible Damoclean uncertainty of hemophilia. Other chronic diseases may handicap a child and dismay the mother, but in time both learn to adjust their lives to the medical facts. In hemophilia, however, there is no status quo. One minute Alexis could be playing happily and normally. The next, he might stumble, fall and begin a bleeding episode that would take him to the brink of death. It could strike at any time in any part of the body: the head, nose, mouth, kidneys, joints, or muscles. Like Queen Victoria’s, Alexandra’s natural reaction was to overprotect her child. The royal family of Spain put its hemophilic sons in padded suits and padded the trees in the park when they went out to play. Alexandra’s solution was to assign the two sailors to hover so closely over Alexis that they could reach out and catch him before he fell. Yet, as Gilliard pointed out to the Empress, this kind of protection can stifle the spirit, producing a dependent, warped and crippled mind. Alexandra responded gallantly, withdrawing the two guardians to permit her son to make his own mistakes, take his own steps and—if necessary—fall and bruise. But it was she who accepted the risk and who bore the additional burden of guilt when an accident followed. To

The impact of second-class treatment on black people’s bodies is devastating. It is manifested not only in the black–white death gap but also in the drastic measures required when chronic disease is left unmanaged. Black patients are less likely than whites to be referred to kidney and liver transplant wait lists and are more likely to die while waiting for a transplant.68 If they are lucky enough to get a donated kidney or liver, blacks are sicker than whites at the time of transplantation and less likely to survive afterward. “Take a look at all the black amputees,” said a caller to a radio show I was speaking on, identifying the remarkable numbers of people with amputated legs you see in poor black communities as a sign of health inequities. According to a 2008 nationwide study of Medicare claims, whites in Louisiana and Mississippi have a higher rate of leg amputation than in other states, but the rate for blacks is five times higher than for whites.69 An earlier study of Medicare services found that physicians were less likely to treat their black patients with aggressive, curative therapies such as hospitalization for heart disease, coronary artery bypass surgery, coronary angioplasty, and hip-fracture repair.70 But there were two surgeries that blacks were far more likely to undergo than whites: amputation of a lower limb and removal of the testicles to treat prostate cancer. Blacks are less likely to get desirable medical interventions and more likely to get undesirable interventions that good medical care would avoid.

Broadly speaking, components of processed foods and animal products, such as saturated fat, trans fat, and cholesterol, were found to be pro-inflammatory, while constituents of whole plant foods, such as fiber and phytonutrients, were strongly anti-inflammatory.938 No surprise, then, that the Standard American Diet rates as pro-inflammatory and has the elevated disease rates to show for it. Higher Dietary Inflammatory Index scores are linked to a higher risk of cardiovascular disease939 and lower kidney,940 lung,941 and liver function.942 Those eating diets rated as more inflammatory also experienced faster cellular aging.943,944 In the elderly, pro-inflammatory diets are associated with impaired memory945 and increased frailty.946 Inflammatory diets are also associated with worse mental health, including higher rates of depression, anxiety, and impaired well-being.947 Additionally, eating more pro-inflammatory foods has been tied to higher prostate cancer risk in men948,949,950 and higher risks of breast cancer,951,952 endometrial cancer,953 ovarian cancer,954 and miscarriages in women. Higher Dietary Inflammatory Index scores are also associated with more risk of esophageal,955 stomach,956 liver,957 pancreatic,958 colorectal,959 kidney,960 and bladder961 cancers, as well as non-Hodgkin lymphoma.962 Overall, eating a more inflammatory diet was associated with 75 percent increased odds of having cancer and 67 percent increased risk of dying from cancer.963 Not surprisingly, those eating more anti-inflammatory diets appear to live longer lives.964,965,966,967 But how does the Dietary Inflammatory Index impact body weight? Obesity and Inflammation:

As Dr. Fauci’s policies took hold globally, 300 million humans fell into dire poverty, food insecurity, and starvation. “Globally, the impact of lockdowns on health programs, food production, and supply chains plunged millions of people into severe hunger and malnutrition,” said Alex Gutentag in Tablet Magazine.27 According to the Associated Press (AP), during 2020, 10,000 children died each month due to virus-linked hunger from global lockdowns. In addition, 500,000 children per month experienced wasting and stunting from malnutrition—up 6.7 million from last year’s total of 47 million—which can “permanently damage children physically and mentally, transforming individual tragedies into a generational catastrophe.”28 In 2020, disruptions to health and nutrition services killed 228,000 children in South Asia.29 Deferred medical treatments for cancers, kidney failure, and diabetes killed hundreds of thousands of people and created epidemics of cardiovascular disease and undiagnosed cancer. Unemployment shock is expected to cause 890,000 additional deaths over the next 15 years.30,31 The lockdown disintegrated vital food chains, dramatically increased rates of child abuse, suicide, addiction, alcoholism, obesity, mental illness, as well as debilitating developmental delays, isolation, depression, and severe educational deficits in young children. One-third of teens and young adults reported worsening mental health during the pandemic. According to an Ohio State University study,32 suicide rates among children rose 50 percent.33 An August 11, 2021 study by Brown University found that infants born during the quarantine were short, on average, 22 IQ points as measured by Baylor scale tests.34 Some 93,000 Americans died of overdoses in 2020—a 30 percent rise over 2019.35 “Overdoses from synthetic opioids increased by 38.4 percent,36 and 11 percent of US adults considered suicide in June 2020.37 Three million children disappeared from public school systems, and ERs saw a 31 percent increase in adolescent mental health visits,”38,39 according to Gutentag. Record numbers of young children failed to reach crucial developmental milestones.40,41 Millions of hospital and nursing home patients died alone without comfort or a final goodbye from their families. Dr. Fauci admitted that he never assessed the costs of desolation, poverty, unhealthy isolation, and depression fostered by his countermeasures. “I don’t give advice about economic things,”42 Dr. Fauci explained. “I don’t give advice about anything other than public health,” he continued, even though he was so clearly among those responsible for the economic and social costs.

Isn’t man an amazing animal? He kills wildlife—birds, kangaroos, deer, and all kinds of cats, coyotes, beavers, groundhogs, mice, foxes and dingoes—by the million in order to protect his domestic animals and their feed. Then he kills domestic animals by the billion and eats them. This in turn kills man by the million, because eating all those animals leads to degenerative—and fatal—health conditions like heart disease, kidney disease, and cancer. So then man tortures and kills millions more animals to look for cures for these diseases. Elsewhere, millions of other human beings are being killed by hunger and malnutrition because food they could eat is being used to fatten domestic animals.20

Science Fiction is a group of symptoms and not a disease,” so a medical student (failed) told me once. “It's like the old disease hydropsy that doctors treated for so long before discovering that it was only a collection of symptoms, sometimes for a heart disease, sometimes for a liver or kidney disease, or sometimes even for a septic throat.” Well, the symptoms for Science Fiction are a prowling avidity to search out and read certain occult texts; an uneasiness or excitement that permates the whole routine of life; it's the ‘itchy ears’, as mentioned in Scripture, seeking for ‘new things’. The symptoms are usually a falcon-like hunting or questing; a series of sudden tuneful encounters; a group of euphorias and buoyancies that cry in opposite directions to be hoarded like misers' treasures and simultaneously to be shared with fellow sufferers of the symptoms; feeling that the ‘World We Live In’ is somehow masked and needs to be unmasked. These and other symptoms indicate either a strange disease or diseases, or they indicate a perpetually new kind of health. Tracing the symptoms back to the ‘disease’ does indicate that the disease is multiple, that it has such names as Hard Science Fiction, Soft Science Fiction, High Fantasy, Low Fantasy, Non-Conforming Adventure Fiction. And sometimes it bears such non-consensus names as Biological Fiction, Ontological Fiction, Eschatological Fiction (did Teilhard, for instance, know that he was writing Eschatological Fiction?), Theological Fiction, or Psychological or Philosophical or Technological or Geological or Historical Fiction. These things and many others share the same complex of symptoms.

These are the risk factors: chronic depression; eating disorders (anorexia nervosa, bulimia); family history of a first-degree relative with osteoporosis; in men, delayed puberty, diminished libido, erectile dysfunction, low testosterone; in women, late menarche, loss of or irregular menstrual periods, or early menopause (estrogen deficiency); low body weight (less than 127 pounds); maternal history of hip fracture; personal history of fracture related to mild-to-moderate trauma as an adult; poor health; chronic disease of the kidneys, gastrointestinal system, or lungs; sedentary lifestyle; and unhealthy lifestyle (tobacco smoke, excessive alcohol, or poor eating habits).

Aged garlic extract 600 mg one to three times a day. Aged garlic extract is used to protect the heart and blood vessels, and is reported to help decrease oxidative stress markers, including those related to blood sugar regulation problems. Aged garlic has also been reported to reduce liver enzymes and fatty liver, as well as decrease the formation of advanced glycation end-products (AGEs), which are implicated in various health problems, such as heart disease, kidney problems, and cancer.

Linda Bacon exposes some of the rarely mentioned side effects of weight-loss surgery in Health at Every Size, listing a shocking eighty-two symptoms, including lifelong vitamin deficiency, loss of bowel control, consistent vomiting and excruciating pain after eating, hormone imbalances, infection, kidney and liver failure, nerve and brain damage, and often, weight regain. Bacon cites further studies that found that 4.6 percent of bariatric surgery patients died within a year. She argues that weight-loss surgery “would be more appropriately labelled ‘high-risk disease-inducing cosmetic surgery’ than a health-enhancing procedure.

Microvascular health would not show up on a scan, but there is an interesting blood number we can use: creatinine. Creatinine is naturally produced bodily junk and one of the kidney’s tasks is to get rid of it.

Now the microvascular health of the kidneys is going to be very similar to the microvascular health everywhere else. So this one measurement is going to give us the big picture—microvascularly speaking. A creatinine level at or above about 1.2 mg/dl is bad.

The full-body scan will reveal these: Amount of heart calcium—the best non-invasive measurement of atherosclerosis. Bone density—how far are you from osteoporosis? 
 Colon problems—any early signs of colon cancer. Thoracic or abdominal aneurisms—these can be fatal and ~4% of people over 65 have one. Cancers or pre-cancerous condition in various organs—includes lungs, liver, gall bladder, spleen, kidneys, adrenal glands, etc.

URINE ALBUMIN/CREATININE RATIO (Ualb/Cr) Albumin is a protein found in urine that can be a sign of increased risk for kidney disease, diabetes complications, and cardiovascular risks. If high levels of Ualb/CR are present, close attention to blood pressure control, including use of specific blood pressure medications that help protect the kidney, may be recommended. Aggressive risk reduction efforts such as closer attention to lipid levels, blood pressure control, and diabetes control are suggested. Goal values More than 30 mg/g suggests increased risk for CVD and diabetic nephropathy More than 300 mg/g signals clinical nephropathy

Oral liquid EDTA chelation removes plaque from blood vessels by dissolving it away. Dissolved plaque exits the body via the kidneys. Blood pressure is reduced to normal (there is no prescription drug that can achieve this youthful result). L-arginine, L-Citrulline which are amino acids (proteins), and antioxidants to stimulate the body’s natural production of Nitric Oxide. These supplements restore youthful flexibility to blood vessels and reduces blood pressure (again, there is no prescription drug that can achieve this youthful result) IMPORTANT NOTE

Perhaps the most significant thing to be aware of here, for anyone who works a desk job, is that sitting is an independent health risk factor—meaning that even if you do exercise, sitting for eight hours each day will still damage your health.124 According to Thomas Yates, MD, “Even for people who are otherwise active, sitting for long stretches seems to be an independent risk factor for conditions like diabetes, cardiovascular disease, and kidney disease.”125

Total T4/Total thyroxine = the amount of T4 bound to a carrier protein and the amount of unbound T4 in the blood. T4 is one-fifth to 1/10 as active as T3. T4 is converted into the more active T3 in the liver and kidneys. Total T3/Total triiodothyronine = the amount of T3 bound to a carrier protein and the amount of unbound T3 in the blood. FREE T3 = the amount of unbound T3 in blood. Low levels could mean an underactive thyroid. FREE T4 = the amount of unbound T4 in blood. Low levels could mean an underactive thyroid. Anti-TPO = anti-thyroid peroxidase (TPO). TPO is an enzyme needed to produce thyroid hormone. High levels of this antibody are an indication of an autoimmune disorder like Hashimoto’s or Graves disease.

One way to quantify the extension of morbidity currently occurring is a metric known as disability-adjusted life years (DALYs), which measures a disease’s overall burden as the number of years lost to ill health plus death.65 According to an impressive recent analysis of medical data worldwide from between 1990 and 2010, the burden of disability caused by communicable and nutrition-related diseases has plunged by more than 40 percent, while the burden of disability caused by noncommunicable diseases has risen, especially in developed nations. As examples, DALYs have risen by 30 percent for type 2 diabetes, by 17 percent for neurological disorders, such as Alzheimer’s, by 17 percent for chronic kidney disease, by 12 percent for musculoskeletal disorders, such as arthritis and back pain, by 5 percent for breast cancer, and by 12 percent for liver cancer.66 Even after factoring in population growth, more people are experiencing more chronic disability that results from noncommunicable diseases. For the diseases just mentioned, the number of years a person can expect to live with cancer has increased by 36 percent, with heart and circulatory diseases by 18 percent, with neurological diseases by 12 percent, with diabetes by 13 percent, and with musculoskeletal diseases by 11 percent.67 To many, old age is now equated with various disabilities (and

However, Pauling’s interest in these carotenoids and flavonoids was confined to their chemical structures and the influence of structure on optical properties; he did not address their health functions. In 1941 Pauling was diagnosed with Bright’s disease, or glomerulonephritis, which was at the time an often-fatal kidney disorder. On the advice of physicians at the Rockefeller Institute, he went to San Francisco for treatment by Thomas Addis, an innovative Stanford nephrologist. Addis prescribed a diet low in salt and protein, plenty of water, and supplementary vitamins and minerals that Pauling followed for nearly 14 years and completely recovered. This was dramatic firsthand experience of the therapeutic value of the diet. Revelations When Pauling cast about for a new research direction in the 1950s, he realized that mental illness was a significant public health problem that had not been sufficiently addressed by scientists. Perhaps his mother’s megaloblastic madness and premature death caused by B12 deficiency underlay this interest. At about this time, Pauling’s eldest son, Linus Jr., began a residency in psychiatry, which undoubtedly prompted Pauling to consider the nature of mental illness. Thanks to funding from the Ford Foundation, Pauling investigated the role of enzymes in brain function but made little progress. When he came across a copy of Niacin Therapy in Psychiatry (1962) by Abram Hoffer in 1965, Pauling was astonished to learn that simple substances needed in minute amounts to prevent deficiency diseases could have therapeutic application in unrelated diseases when given in very large amounts. This serendipitous and key event was critically responsible for Pauling’s seminal paper in his emergent medical field. Later, Pauling was especially excited by Hoffer’s observations on the survival of patients with advanced cancer who responded well to his micronutrient and dietary regimen, originally formulated to help schizophrenics manage their illness.19,20 The regimen includes large doses of B vitamins, vitamin C, vitamin E, beta-carotene, selenium, zinc, and other micronutrients. About 40 percent of patients treated adjunctively with Hoffer’s regimen lived, on average, five or more years, and about 60 percent survived four times longer than controls. These results were even better than those achieved by Scottish surgeon Ewan Cameron, Pauling’s close clinical collaborator, in Scotland. After a long and extremely productive career at Caltech,

Acidosis can lead to chronic headaches, sleepiness or even insomnia, vertigo, seizures, diarrhoea, shortness of breath, chronic cough, palpitation, indigestion, reflux, heartburn, loss of calcium in the body, weakness in the bones, dry skin and other skin disorders including rashes, acne, body odour, increased risk of formation of kidney and bladder stones, accelerated ageing, degenerative diseases, fatigue and hormonal and glandular disorders. And I have only just scraped the surface here. When

The vitamin-C molecule is similar in configuration to glucose and other sugars in the body. It is shuttled from the bloodstream into the cells by the same insulin-dependent transport system used by glucose. Glucose and vitamin C compete in this cellular-uptake process, like strangers trying to flag down the same taxicab simultaneously. Because glucose is greatly favored in the contest, the uptake of vitamin C by cells is “globally inhibited” when blood-sugar levels are elevated. In effect, glucose regulates how much vitamin C is taken up by the cells, according to the University of Massachusetts nutritionist John Cunningham. If we increase blood-sugar levels, the cellular uptake of vitamin C will drop accordingly. Glucose also impairs the reabsorption of vitamin C by the kidney, and so, the higher the blood sugar, the more vitamin C will be lost in the urine. Infusing insulin into experimental subjects has been shown to cause a “marked fall” in vitamin-C levels in the circulation. In

GLYCEMIC INDEX (GI) AND GLYCEMIC LOAD (GL) OF COMMON PLANT FOODS* FOOD GI GL Black beans 30 7 Red kidney beans 25 8 Lentils 30 5 Split peas 25 6 Black-eyed peas 30 13 Corn 52 9 Barley 35 16 Brown rice 75 18 Millet 71 25 Rolled oats 55 13 White rice 83 23 Whole wheat 70 14 White pasta 55 23 Sweet potato 61 17 White potato (average) 90 26 There is a nutritional hierarchy of carbohydrate-rich plant foods.

According to the American Heart Association, people with type 2 diabetes are two- to four-times more likely to have a stroke and two- to four-times more likely to die of heart disease. Type 2 diabetes can also lead to kidney damage or kidney failure, diseases of the eye and loss of vision, and nerve damage.

I was riddled with memory issues that became so severe at the age of 45 that I had to apply for disability benefits. At the age of 50, my mental functioning was in decline with severe short term memory issues, concentration problems and chronic fatigue. My kidneys were testing bad on blood tests. The USA has refused all applications for occupational disease and disability benefits.

Robert had been under the care of a nephrologist for years prior to reaching end-stage kidney disease but didn’t hear about kidney transplant as an option until months after starting dialysis. Now in all fairness, few nephrologists would begin a conversation about kidney replacement options before the patient’s kidney function—their estimated glomerular filtration rate or eGFR, how fast the kidneys filter the blood—had fallen to 25 milliliters per minute, and the patient cannot be placed on the kidney transplant waiting list until kidney function reaches 20. The medical world tends to simplify the explanation of eGFR to patients as “percent function,” though 100 percent function of normal kidneys in a young person can be closer to 125 milliliters per minute, so a more accurate and easier-to-understand explanation would be that we start out with about half a cup, or 25 teaspoons, of blood flowing through our kidneys’ filters every minute. Using this analogy, nephrologists usually start talking about kidney replacement options when it has dropped to 5 teaspoons a minute, and a patient can be placed on the waiting list once his kidney function has dropped to 4 teaspoons a minute.

The slightest brushing of my hand against my penis was not only a religious sin, but would lead to blindness and pimples, kidney disease, bed-wetting, stooped shoulders, insomnia, weight loss, fatigue, stomach trouble, impotence, genital cancer, and ulcers.” In fact, he so deeply internalized his aunts’ great fear of sexual “filth” that the unintentional discovery that his foreskin could retract (and the sudden sight of his filth-encrusted glans) shocked him so deeply that he passed out cold.

found you on the CRISP website. I was looking for someone at UCSF with an R01 doing research in kidney disease,” I said. CRISP, now called the NIH RePORTER, was the National Institutes of Health’s searchable database of all federally funded biomedical research projects. I knew that the NIH’s R01 grant mechanism, which was awarded to researchers who no longer needed a research mentor, allowed the researcher to apply for smaller research grants to support someone from backgrounds underrepresented in medicine—Blacks, Hispanics, or Native Americans, individuals with a physical or mental disability, or those who grew up in poverty—at every level of education, from a high school student to a college student, a medical student, resident, or fellow.

Though I wasn’t aware of it at the time, a small but growing body of research supported my intuition. It showed that patients similar to Mrs. Lee—over seventy-five and with serious medical problems in addition to advanced kidney disease—were as likely to live as long without dialysis as with it and often with a better quality of life. This research comes mostly from the United Kingdom, where about 15 percent of elderly patients with end-stage kidney disease die without ever starting dialysis. They have programs in place to provide conservative management—treatment aimed at minimizing symptoms of kidney failure while maximizing the quality of life remaining without dialysis.

As a fellow in the pre-dialysis clinic, what I observed for how to have discussions with patients approaching end-stage kidney disease seemed consistent with the monolithic, unquestioning agenda implied by the clinic name. The response to patient hesitation toward dialysis or outright refusal of it often felt threatening, coercive, even bullying to me. “Start dialysis or you’ll be dead in two weeks.” “You have a responsibility to your grandchildren to be here.

While tools to estimate prognosis among dialysis patients and tools to estimate prognosis among patients with advanced kidney disease are in development, without a crystal ball it is doubtful that any tool will ever have enough precision for nephrologists to feel assured of accuracy for the patient before us. However, since the vast majority of patients and families only have their experience with illness up to the present moment, our clinical knowledge and experiences with similar patients about what the future may hold are invaluable—and should be shared.

Low-cost, high-frequency expenditures are those that need to be undertaken for common illnesses that occur periodically or those for the prevention and early treatment of conditions such as chronic kidney disease, cervical cancer, pre-eclampsia, suicide mortality and damage due to glaucoma. These represent small expenditures that are affordable to most people but are often not incurred by individuals either because of the twin phenomena of distorted perception and behaviour, and a gap in understanding about what they need, or because of gaps in health services delivery or access to basic financial services.

At least 90 percent of your diet should be from whole plant foods such as the following: Green vegetables—including kale, Swiss chard, broccoli, artichokes, string beans, asparagus, spinach, cabbage, lettuce, snow peas, and peas Yellow/orange vegetables—including carrots, butternut squash, winter squash, spaghetti squash, sweet potato, and corn Beans/legumes—including chickpeas, red kidney beans, lentils, and adzuki beans Fresh fruits—including blueberries, strawberries, kiwis, apples, oranges, grapes, pears, watermelon, and pomegranates (Eat dried fruits, including raisins and dates, only in small amounts.) Nonstarchy vegetables—including eggplant, mushrooms, peppers, tomatoes, and onions

I had been researching high altitude diseases and their links to COVID-19, as both conditions are linked through hypoxia, also known as oxygen starvation or asphyxia. As the COVID-19 pandemic was progressing, more information was coming out about a debilitating condition called “Long COVID”. In particular, the damage it was wreaking on the kidneys. The lungs were typically the most damaged organ in surviving COVID-19 patients, followed by the kidneys.

I was fortunate I had uncovered the protein intolerance before I became too sick to research it. I only uncovered it so quickly because it had coincided with research I was doing on hypoxic kidney damage and I was aware of the link to protein in urine. Had I gone back into a state of permanent chronic fatigue, I would have needed to move in with my parents.

The best thing to do," said one of the malingerers, "is to sham madness. In the next room there are two other men from the school where I teach and one of them keeps shouting day and night : 'Giordano Bruno's stake is still smoldering ; renew Galileo's trial !'” “I meant at first to act the fool too and be a religious maniac and preach about the infallibility of the Pope, but finally I managed to get some cancer of the stomach for fifteen crowns from a barber down the road." "That's nothing," said another man. "Down our way there's a midwife who for twenty crowns can dislocate your foot so nicely that you're crippled for the rest of your life.” “My illness has run me into more than two hundred crowns already," announced his neighbor, a man as thin as a rake. "I bet there's no poison you can mention that I haven't taken. I'm simply bung full of poisons. I've chewed arsenic, I've smoked opium, I've swallowed strychnine, I've drunk vitriol mixed with phosphorus. I've ruined my liver, my lungs, my kidneys, my heart—in fact, all my insides. Nobody knows what disease it is I've got." "The best thing to do," explained someone near the door, "is to squirt paraffin oil under the skin on your arms. My cousin had a slice of good luck that way. They cut off his arm below the elbow and now the army'll never worry him any more.” “Well," said Schweik, "When I was in the army years ago, it used to be much worse. If a man went sick, they just trussed him up, shoved him into a cell to make him get fitter. There wasn't any beds and mattresses and spittoons like what there is here. Just a bare bench for them to lie on. Once there was a chap who had typhus, fair and square, and the one next to him had smallpox. Well, they trussed them both up and the M. O. kicked them in the ribs and said they were shamming. When the pair of them kicked the bucket, there was a dust-up in Parliament and it got into the papers. Like a shot they stopped us from reading the papers and all our boxes was inspected to see if we'd got any hidden there. And it was just my luck that in the whole blessed regiment there was nobody but me whose newspaper was spotted. So our colonel starts yelling at me to stand to attention and tell him who'd written that stuff to the paper or he'd smash my jaw from ear to ear and keep me in clink till all was blue. Then the M.O. comes up and he shakes his fist right under my nose and shouts: 'You misbegotten whelp ; you scabby ape ; you wretched blob of scum ; you skunk of a Socialist, you !' Well, I stood keeping my mouth shut and with one hand at the salute and the other along the seam of my trousers. There they was, running round and yelping at me. “We'll knock the newspaper nonsense out of your head, you ruffian,' says the colonel, and gives me 21 days solitary confinement. Well, while I was serving my time, there was some rum goings-on in the barracks. Our colonel stopped the troops from reading at all, and in the canteen they wasn't allowed even to wrap up sausages or cheese in newspapers. That made the soldiers start reading and our regiment had all the rest beat when it came to showing how much they'd learned.

In Canada, an estimated one in three people lives with at least one chronic disease. Conditions that appeared to increase the risk and severity of COVID-19 included type 2 diabetes, obesity, high blood pressure and other heart conditions, chronic obstructive pulmonary disease (COPD), chronic kidney disease and cancer. All of these conditions have been shown to be associated with inadequate diets and malnutrition, either as a cause or consequence of the disease. We normally associate the word "malnutrition" with undernutrition or starvation. However, malnutrition also applies to overconsumption of calories, protein or fat and frequently results in overweight or obesity. A well-primed immune response depends on good nutrition to function, and malnutrition is known to increase susceptibility to infections. In turn, infection can aggravate malnutrition, since it increases the body's demand for nutrients. This creates a vicious cycle, further increasing vulnerability to infection. In Canada, malnutrition is much more widespread than we would like to believe. A cross-Canada study conducted in eighteen hospitals screened patients for malnutrition on admission and found 45 per cent of them to be malnourished. Those who were malnourished had significantly longer hospital stays than those who were not.

The toxic effects of acetaminophen are accelerated by alcohol use. Chronic acetaminophen use and chronic alcohol abuse have been separately linked to kidney and liver disease, according to Dr. Martin Zand, medical director of the kidney and pancreas transplant programs at the University of Rochester Medical Center in New York. If you want to give your liver a break, avoid acetaminophen.

The heart is essentially a muscular pump connected to an elaborate network of branching tubes. Although there are several kinds of cardiovascular disease, almost all arise from something going wrong in either the tubes or the pump. Most problems start with the tubes, primarily the arteries that carry blood from the heart to every nook and cranny of the body. Like the pipes in a building, arteries are vulnerable to getting clogged with unwanted deposits. This hardening of the arteries, termed atherosclerosis, starts with the buildup of plaque—a gloppy mixture of fat, cholesterol, and calcium—within the walls of arteries. Plaques, however, don’t simply accumulate in arteries like crud settling in a pipe. Instead, they are dynamic, changing, growing, shifting, and sometimes breaking. They develop when white blood cells in arteries trigger inflammation by reacting to damage usually caused by a combination of high blood pressure and so-called bad cholesterol that irritates the walls of the artery. In an effort to repair the damage, white blood cells produce a foamy mixture that incorporates cholesterol and other stuff and then hardens. As plaque accumulates, arteries stiffen and narrow, sometimes preventing enough blood from flowing to the tissues and organs that need it and further driving up blood pressure. One potentially lethal scenario is when plaques block an artery completely or detach and obstruct a smaller artery elsewhere. When this happens, tissues are starved of blood (also called ischemia) and die. Plaques can also cause the artery wall to dilate, weaken, and bulge (an aneurysm) or to tear apart (a rupture), which can lead to massive bleeding (a hemorrhage). Blocked and ruptured arteries create trouble anywhere in the body, but the most vulnerable locations are the narrow coronary arteries that supply the heart muscle itself. Heart attacks, caused by blocked coronary arteries, may damage the heart’s muscle, leading to less effective pumping of blood or triggering an electrical disturbance that can stop the heart altogether. Other highly vulnerable arteries are in the brain, which cause strokes when blocked by blood clots or when they rupture and bleed. To this list of more susceptible locations we should also add the retinas, kidneys, stomach, and intestines. The most extreme consequence of coronary artery disease is a heart attack, which, if one survives, leaves behind a weakened heart unable to pump blood as effectively as before, leading to heart failure.

Instead, excess protein is physiologically converted to an inefficient energy source or alternatively stored as fat. And concerning everyone, copious studies have established beyond doubt that over the long term, excess protein intake from animal-based sources can be harmful, significantly contributing to the onset of a variety of congenital diseases such as osteoporosis, cancer, impaired kidney function, and heart disease.

Men in the United States appear to have eleven times more colorectal cancer than men in India, twenty-three times more prostate cancer, fourteen times more melanoma, nine times more kidney cancer, and seven times more lung and bladder cancer.

Magnesium’s role in bone health is multifaceted. • Adequate levels of magnesium are essential for the absorption and metabolism of calcium. • Magnesium stimulates a particular hormone, calcitonin, that helps to preserve bone structure and draws calcium out of the blood and soft tissues back into the bones, preventing some forms of arthritis and kidney stones. • Magnesium suppresses another bone hormone called parathyroid, preventing it from breaking down bone. • Magnesium converts vitamin D into its active form so that it can help calcium absorption. • Magnesium is required to activate an enzyme that is necessary to form new bone. • Magnesium regulates active calcium transport. With all these roles for magnesium to play, it is no wonder that even a mild deficiency can be a risk factor for osteoporosis. Further, if there is too much calcium in the body, especially from calcium supplementation, as in Muriel’s case, magnesium absorption can be greatly impaired, resulting in worsening osteoporosis and the likelihood of kidney stones, arthritis, and heart disease. A chance meeting in a hotel with a woman whose lymphoma worsened immediately after being prescribed 2,500 mg of calcium, but no magnesium, for her osteoporosis made me consider that excess calcium can also deposit in cancerous tumors. Other factors that are important in the development of osteoporosis include diet, drugs, endocrine imbalance, allergies, vitamin D deficiency, and lack of exercise. A detailed review of the osteoporosis literature shows that chronically low intake of magnesium, vitamin D, boron, and vitamins K, B12, B6, and folic acid leads to osteoporosis.

Both types of diabetes accelerate the aging of our bodies. Having diabetes greatly speeds up the development of atherosclerosis, or cardiovascular disease. Diabetes also ages and destroys the kidney and other body systems. Forty thousand amputations per year are due to complications of diabetes. It is the leading cause of blindness in adults and of kidney failure.

Diabetes – the physical costs Hypertension: 70% of diabetics also require medication for blood pressure. Cholesterol: 65% of diabetics require medication to reduce their cholesterol. Heart attacks: Diabetics, even when on full medication, are twice as likely to be hospitalised, crippled or die from a heart attack. Strokes: Diabetics are 1.5 times more likely to suffer a debilitating stroke. Blindness and Eye Problems: Diabetes is the number one cause of preventable blindness in the developed world. Impotence: Diabetes is also the number one cause of impotence. Dementia: Having diabetes doubles your risk of dementia. Kidney disease: Diabetes is the cause of kidney failure in half of all new cases; most people on dialysis are diabetics. Amputations: There are over 7000 diabetes-related amputations done every year in the UK and over 73,000 in the US.

The concentration of sodium in the blood is controlled to within a very narrow range. When intake rises, the kidneys excrete the excess. When intake falls below 3 to 4 grams a day, the body compensates by activating powerful hormones, called the renin-angiotensin system (RAS), which helps the kidneys hold on tightly to salt.65 The problem is, receptors for RAS are present not only in the kidneys, but also in fat cells, muscle, the pancreas, the lining of the blood vessels, and elsewhere. Overactivity of this system has been shown to cause fat cell dysfunction, insulin resistance, and inflammation—the fundamental problems linking obesity to diabetes and heart disease.

What is diabetes? The term diabetes refers to a group of diseases that affect the way your body uses blood glucose, commonly called blood sugar. Glucose is vital to your health because it’s the main source of energy for the cells that make up your muscles and tissues. It’s your body’s main source of fuel. If you have diabetes — no matter what type — it means you have too much glucose in your blood, although the reasons why may differ. And too much glucose can lead to serious problems. To understand diabetes, it helps to understand how your body normally processes blood glucose. Processing of blood glucose Blood glucose comes from two major sources: the food you eat and your liver. During digestion, glucose is absorbed into your bloodstream. Normally, it then enters your body’s cells, aided by the action of insulin. The hormone insulin comes from your pancreas. When you eat, your pancreas secretes insulin into your bloodstream. As insulin circulates, it acts like a key, unlocking microscopic doors that allow glucose to enter your cells. In this way, insulin lowers the amount of glucose in your bloodstream and prevents it from reaching high levels. As your blood glucose level drops, so does the secretion of insulin from your pancreas. Your liver acts as a glucose storage and manufacturing center. When the level of insulin in your blood is high, such as after a meal, your liver stores extra glucose as glycogen in case your cells need it later. When your insulin levels are low, for example, when you haven’t eaten in a while, your liver releases the stored glucose into your bloodstream to keep your blood sugar level within a normal range. When you have diabetes If you have diabetes, this process doesn’t work properly. Instead of being transported into your cells, excess glucose builds up in your bloodstream, and eventually some of it is excreted in your urine. This usually occurs when your pancreas produces little or no insulin, or your cells don’t respond properly to insulin, or for both reasons. The medical term for this condition is diabetes mellitus (MEL-lih-tuhs). Mellitus is a Latin word meaning “honey sweet,” referring to the excess sugar in your blood and urine. Another form of diabetes, called diabetes insipidus (in-SIP-uh-dus), is a rare condition in which the kidneys are unable to conserve water, leading to increased urination and excessive thirst. Rather than an insulin problem, diabetes insipidus results from a different hormone disorder. In this book, the term diabetes refers only to diabetes mellitus.

In late 1985, the Reagan White House blocked the use of CDC money for education, leaving the US behind other Western nations in telling its citizens how to avoid contracting the virus. Many Americans still thought you could get AIDS from a toilet seat or a glass of water. According to one poll, the majority of Americans supported quarantining AIDS patients. This heightened awareness set off waves of anxiety across the country, which was often express through jokes (Q: What do you call Rock Hudson in a wheelchair? A: Roll-AIDS!) and violence. Between the years 1985 and 1986, anti-gay violence increased by 42 percent in the US. Even in San Francisco, where Greyhound buses still dropped off gay men and women taking refuge from the prejudice of their hometowns, carloads of teenagers would drive through the Castro looking for targets. In December 1985, a group of teenagers, shouting “diseased faggot” and “you’re killing us all,” dragged a man named David Johnson from his car in a San Francisco parking lot. While his lover looked on in horror, the teenagers kicked and beat Johnson with their skateboards, breaking three of his ribs, bruising his kidneys, an gashing his face and neck with deep fingernail scratches.

Chronic Kidney Disease Karma Ayurveda is an ancient Ayurveda company which provides many valuable natural remedies for kidney patients which help to keep kidney problem under control.Karma Ayurveda medicine reduces dialysis, frequency at first, and sometime kidneys can be brought to its normal function.

Primary hyperparathyroidism Primary hyperparathyroidism is caused by autonomous secretion of PTH, usually by a single parathyroid adenoma which can vary in diameter from a few millimetres to several centimetres. It should be distinguished from secondary hyperparathyroidism, in which there is a physiological increase in PTH secretion to compensate for prolonged hypocalcaemia (such as in vitamin D deficiency, p. 1121), and tertiary hyperparathyroidism, in which continuous stimulation of the parathyroids over a prolonged period of time results in adenoma formation and autonomous PTH secretion (Box 20.37). This is most commonly seen in individuals with advanced chronic kidney disease (p. 487).

In 1975, Richard Doll and Bruce Armstrong published a seminal analysis of diet and cancer, in which they noted that, the higher the sugar intake in different nations, the higher both the incidence of and mortality from cancer of the colon, rectum, breast, ovary, uterus, prostate, kidney, nervous system, and testicles.

Removing carbohydrates from the diet works, in effect, just like the antihypertensive drugs known as diuretics, which cause the kidneys to excrete sodium, and water along with it.

Eating carbohydrates prompts the kidneys to hold on to salt, rather than excrete it. The body then retains extra water to keep the sodium concentration of the blood constant. So, rather than having water retention caused by taking in more sodium, which is what theoretically happens when we eat more salt, carbohydrates cause us to retain water by inhibiting the excretion of the sodium that is already there.

Examining Type 2 Diabetes Most people with type 2 diabetes, which used to be known as adult onset diabetes or noninsulin dependent diabetes, are over the age of 40. Your chances of getting type 2 diabetes increase as you get older. Because the symptoms are so mild at first, you may not notice them. You may ignore these symptoms for years before they become bothersome enough to consult your doctor. So type 2 diabetes is a disease of gradual onset rather than the severe emergency that can herald type 1 diabetes. No autoimmunity is involved in type 2 diabetes, so no antibodies are found. Doctors believe that no virus is involved in the onset of type 2 diabetes. Recent statistics show that worldwide, ten times more people have type 2 diabetes than type 1 diabetes. Although type 2 is the much more prevalent type of diabetes, those with type 2 diabetes seem to have milder severity of complications (such as eye disease and kidney disease) from diabetes. Identifying

Fresh foods contain more potassium than sodium. In fact, if foods are unprocessed, they contain potassium that is 5 to 10 times more than sodium, which is the ratio that the bodies of hunter-gatherers adapted during their time. Potassium is beneficial for the kidneys, heart, and other organs in the body. A person with low potassium level is prone to heart disease, stroke, and high blood pressure, which are also associated with excessive intake of sodium. Nowadays, the average American’s intake of sodium is twice as much as potassium.

According to a large study from Kaiser Permanente, for every 0.05 increase above 4.72, patients had an additional 6 percent increased risk of developing diabetes in the next ten years (4.82 = 12 percent increased risk, etc.) Above 5 indicates that vascular damage has already occurred and a patient is at risk for having damage to the kidneys and eyes. Why is high fasting blood sugar a problem? High blood sugar causes vascular problems throughout your whole body, including your brain. Over time, it causes blood vessels to become brittle and vulnerable to breakage. It leads not only to diabetes but also to heart disease, strokes, visual impairment, impaired wound healing, wrinkled skin, and cognitive problems. Diabetes doubles the risk for Alzheimer’s disease.

Protein and the Story of the AGEs Advanced glycation end-products (AGEs) can do some serious damage, especially over time. An article in The Clinical Journal of the American Society of Nephrology makes several important points about protein and its relationship to many of the diseases of aging: • Human studies indicate that excess dietary protein promotes progressive kidney damage by increasing the AGE burden. • A prudent approach is to recommend that people with chronic kidney disease achieve the recommended dietary allowance of protein—0.8 g/kg per day, or about 10 percent of total caloric intake— with an emphasis on high-quality protein, low in AGEs. • Conversely, very low dietary protein intake may lead to malnutrition, especially in those with advanced chronic kidney disease. • The dietary AGE load can be minimized by consuming nonmeat proteins. • There are several culinary methods that reduce AGE formation during cooking—steaming, poaching, boiling, and stewing. Frying, broiling, or grilling should be avoided, as they promote AGE formation. • Limitation of dietary AGEs seems prudent in those with obesity, diabetes, and other risk factors for chronic kidney disease.i With the gradual onset of kidney failure, acidosis again ensues and will lead to all types of inflammation and metabolic abnormalities. The preceding recommendations for how to avoid turning a meal into AGEs should become a major agingmanagement technology for Baby Boomers everywhere. — Leonard Smith, M.D.

sputter, add

In every man, of course, a demon lies hidden—the demon of rage, the demon of lustful heat at the screams of the tortured victim, the demon of lawlessness let off the chain, the demon of diseases that follow on vice, gout, kidney disease, and so on.   “This

This Superfood, Asparagus

Nearly all diseases that have baffled the medical profession may be traced to some deficiency in our diet, and it may be truthfully said, that at least ninety per cent of human ailments are traceable to inadequate and faulty nutrition. Yet in no part of study and observation has medical need been more insufficiently met than in that of rational dietetics, both in relation to the maintenance of health, and in the treatment and prevention of disease. By far the most detrimental effect of faulty nutrition is the result of habitual errors of one kind or another, which are not sufficiently grave to command immediate attention. For instance, we may abuse our pancreas and kidneys for years, without the feeling of pain, until these organs are finally injured beyond repair. It is the gradual operation of more or less constant, but unperceived causes, rather than of accidental exposures to abnormal conditions, which in most cases are responsible for undermining the health of the individual

Kidney beans contain a high level of a very toxic and immunogenic agglutinin called phytohaemagglutinin (sometimes called kidney bean lectin). Phytohaemagglutinin is also found to a lesser extent in cannellini beans, common beans, and broad beans, such as fava beans. As few as five raw kidney beans can cause extreme gastrointestinal distress, with symptoms like those of food poisoning (not that anyone would want to eat raw kidney beans).

But the primary problem is the excessive insulin, not the insulin resistance. The tissues (heart, nerves, kidney, eyes) are all increasing their resistance to protect themselves from insulin’s toxic delivery. The disease is not insulin resistance. The disease is hyperinsulinemia.

This is precisely why T2DM, unlike virtually any other disease, affects every single part of the body. Every organ suffers the long-term effects of the excessive sugar load. Your eyes rot – and you go blind. Your kidneys rot – and you need dialysis. You heart rots – and you get heart attacks and heart failure. Your brain rots – and you get Alzheimer’s disease. Your liver rots – and you get fatty liver disease and cirrhosis. Your legs rot – and you get diabetic foot ulcers. Your nerves rot – and you get diabetic neuropathy. No part of your body is spared.

When a patient presents with symptoms of diabetes or heart disease, and the treatment is lifelong, the general population accepts the diagnosis as a matter of physical health. Unfortunately, diseases of the brain are classified and perceived differently than diseases of the body. Your brain forms your personality. Your behavior is the result of the disease, of the brain misfiring. It’s easier to separate blame and fault from an impaired kidney or a damaged aorta than from an obsessive, compulsive, phobic person.

Pomegranates inhibit breast cancer, prostate cancer, colon cancer, and leukemia, and prevent vascular changes that promote tumor growth in lab animals.55 2. Pomegranates inhibit angiotensin-converting enzymes and naturally lower blood pressure. (Angiotensin, as you may recall, is a hormone that promotes angiogenesis.)56 3. The potent antioxidative compounds in pomegranates reverse atherosclerosis and reduce excessive blood clotting and platelet clumping, factors that can lead to heart attacks and strokes.57 4. Pomegranates have estrogen-like compounds that stimulate serotonin and estrogen receptors, improving symptoms of depression and helping build bone mass in lab animals.58 5. Pomegranates reduce tissue damage in those with kidney problems, reduce the incidence of infections, and prevent serious infections.59 6. Lastly but impressively, pomegranates improve heart health. Heart patients with severe carotid artery blockages were given a daily dose of less than an ounce of pomegranate juice for a year. Not only did their blood pressure decrease by over 20 percent, but there was a 30 percent reduction in atherosclerotic plaque.60

Finn wanted to collect the plants he knew he could sell, and he was teaching Maia. He climbed to the top of the leaf canopy and came back with clusters of yellow fruits which could be boiled up to treat skin diseases. He found a tree whose leaves were made into an infusion to help people with kidney complaints and brought back a silvery fern to rub on aching muscles. Most of these plants had Indian names, but as they sorted their specimens and put them to be dried and stored in labeled cotton bags, Maia learned quickly. “You’d be amazed how much money people give for these in the towns,” said Finn. But not everything he collected was for sale. He restocked his own medicine chest also. And every day he bullied Maia about taking her quinine pills. “Only idiots get malaria in the dry season,” he said.

Stigma is a terrible word in the world of quiet sufferers. Cold Creek, and its staff of professionals, has worked closely with patients and families to relieve them of the shame associated with mental illness. When a patient presents with symptoms of diabetes or heart disease, and the treatment is lifelong, the general population accepts the diagnosis as a matter of physical health. Unfortunately, diseases of the brain are classified and perceived differently than diseases of the body. Your brain forms your personality. Your behavior is the result of the disease, of the brain misfiring. It’s easier to separate blame and fault from an impaired kidney or a damaged aorta

A small series of 42 participants compared patients with and without revascularization and found higher mortality (17% versus 7%) in patients without revascularization, but higher eGFR decline (19.5 mL/min versus 6 mL/min) in patients with revascularization.

Using this technique, Baum et al constructed a forest that contained 1,000 decision trees and looked at 84 co-variates that may have been influencing patients' response or lack of response to the intensive lifestyle modifications program. These variables included a family history of diabetes, muscle cramps in legs and feet, a history of emphysema, kidney disease, amputation, dry skin, loud snoring, marital status, social functioning, hemoglobin A1c, self-reported health, and numerous other characteristics that researchers rarely if ever consider when doing a subgroup analysis. The random forest analysis also allowed the investigators to look at how numerous variables *interact* in multiple combinations to impact clinical outcomes. The Look AHEAD subgroup analyses looked at only 3 possible variables and only one at a time. In the final analysis, Baum et al. discovered that intensive lifestyle modification averted cardiovascular events for two subgroups, patients with HbA1c 6.8% or higher (poorly managed diabetes) and patients with well-controlled diabetes (Hba1c < 6.8%) and good self-reported health. That finding applied to 85% of the entire patient population studied. On the other hand, the remaining 15% who had controlled diabetes but poor self-reported general health responded negatively to the lifestyle modification regimen. The negative and positive responders cancelled each other out in the initial statistical analysis, falsely concluding that lifestyle modification was useless. The Baum et al. re-analysis lends further support to the belief that a one-size-fits-all approach to medicine is inadequate to address all the individualistic responses that patients have to treatment. 

detoxification. This is the body’s natural process of removing toxins, or any substance that can cause cell injury and disease. Toxins include internal waste from our own metabolic processes, as well as external waste from drugs, pollutants, harmful germs, or radiation. The primary detox organ is the liver, but there are accessory detox organs, too: a healthy gut rids our bodies of waste via stool; the skin via sweat; the lungs via mucus and exhalation; the kidneys via urine; and the immune system via lymphatic channels. The only way I had known before to reduce pollutants in the body was to live a clean life and eat a nutrient-dense diet. Though still important to reduce harmful chemicals, for myself and for the planet, certain foods and nutrients could help my body more efficiently metabolize and eliminate harmful substances. That is, in addition to 5: Detoxify the house, we can detoxify our bodies—(and detoxify yourself).

One hundred percent of the nearly 1 million pounds of chloroform released in Mobile County in 1988 was released in Africatown. Chloroform is classified as a probable carcinogen by the EPA. Chronic long-term exposure, such as one would experience living in the shadow of two paper mills, can cause liver disease and affect the central nervous system. One hundred percent of the chlorine dioxide in the county was released in Africatown. Nearly all of the 1.8 million pounds of hydrochloric acid released in the county in 1988 was released in Africatown. Nearly all of the acetone, methanol, xylene, chlorine, methyl ethyl ketone, and toluene released in the county were released in Africatown. The chemicals are linked to cancer, birth defects, fertility problems, kidney and liver damage, nose and throat irritation, asthma, and loss of hearing and color vision.

As strange as it sounds, it is no longer possible to determine how many human genomes have been sequenced. At present the strategy of choice is whole-genome re-sequencing (Chapter 3) whereby next-generation sequence data are mapped onto a reference genome. The results have been breathtaking. The recently concluded (and aptly named) 1000 Genomes Project Consortium catalogued ~85 million SNPs, 3.6 million short insertions/deletions, and 60,000 larger structural variants in a global sampling of human genetic diversity. These data are catalysing research in expected and unexpected ways. Beyond providing a rich source of data for GWA-type studies focused on disease, scientists are also using the 1000 Genomes Project data to learn about our basic biology, something that proved surprisingly difficult when only a pair of genomes was available. For example, a recent GWAS taking advantage of the 1000 Genomes Project data identified ten genes associated with kidney development and function, genes that had previously not been linked to this critical aspect of human physiology. In 2016, Craig Venter’s team reported the sequencing of 10,545 human genomes. Beyond the impressively low cost (US$1,000–2,000 per genome) and high quality (30–40× coverage), the study was significant in hinting at the depths of human genome diversity yet to be discovered. More than 150 million genetic variants were identified in both coding and non-coding regions of the genome; each sequenced genome had on average ~8,600 novel variants. Furthermore, each new genome was found to contain 0.7 Mbp of sequence that is not contained in the reference genome. This underscores the need for methods development in the area of structure variation detection in personal genome data. Overall, however, the authors concluded that ‘the data generated by deep genome sequencing is of the quality necessary for clinical use’.

A Protein Is Not a Protein Companies are touting protein as a cure-all and for weight loss/muscle gain. They’re selling protein shakes, protein cookies, protein snack bars, even protein coffee. It’s true that protein is neither carbohydrate nor sugar nor fat, and you need it to maintain normal growth. However, your kidneys have a limited capacity to excrete the metabolic by-products of protein metabolism, and overexcretion can cause kidney damage. Therefore, protein quality is as important as protein quantity. For example, eggs and beans both contain protein, but are very different in quality. Dietary protein is made up of twenty separate amino acids strung together in different combinations and amounts. One of those amino acids, tryptophan, is rarer and therefore more important than others, because it’s the precursor of serotonin, an important brain neurotransmitter (see Chapter 19). Eggs, poultry, and fish are the best sources of this amino acid, while beans have very little. On the other hand, additional protein is needed if you’re building muscle, especially branched-chain amino acids (BCAAs; leucine, isoleucine, valine), which are 20 percent of muscle (see Chapter 18). BCAAs are in high concentration in corn products, and are what’s in those tubs of protein powder at the health food store. If you’re a bodybuilder, you need them; if you’re not a gym rat and consume excess BCAAs, your liver will take the amino groups off and turn them into organic acids, which will either be diverted into liver fat (through DNL) or into excess glucose, either of which can generate hyperinsulinemia and drive chronic disease. The goal is to get more tryptophan and less BCAAs in the protein you consume.

disease76 375,000 2. Lung diseases (lung cancer,77 COPD, and asthma78) 296,000 3. You’ll be surprised! (see chapter 15) 225,000 4. Brain diseases (stroke79 and Alzheimer’s80) 214,000 5. Digestive cancers (colorectal, pancreatic, and esophageal)81 106,000 6. Infections (respiratory and blood)82 95,000 7. Diabetes83 76,000 8. High blood pressure84 65,000 9. Liver disease (cirrhosis and cancer)85 60,000 10. Blood cancers (leukemia, lymphoma, and myeloma)86 56,000 11. Kidney disease87 47,000 12. Breast cancer88 41,000 13. Suicide89 41,000 14. Prostate cancer90 28,000 15. Parkinson’s disease91 25,000