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Through . . . lies you try to run your life and manipulate others. . . . Lies become an inhibitor in your relationship . . . .
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William Paul Young (The Shack)
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He had to admit that the biggest inhibitor to change lies within yourself, and that nothing gets better until you change.
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Spencer Johnson
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Fear is an inhibitor that has kept more people from fulfilling their destiny than any other one emotion.
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Tim LaHaye (Spirit-Controlled Temperament)
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In pharmaceutical speak, psilocybin is known as an asshole inhibitor.
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Bill Maher
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Or, if you want to go just a wee bit deeper, we could talk about the nature of freedom itself. Does freedom mean that you are allowed to do whatever you want to do? Or we could talk about all the limiting influences in your life that actively work against your freedom. Your family genetic heritage, your specific DNA, your metabolic uniqueness, the quantum stuff that is going on at a subatomic level where only I am the always-present observer. Or the intrusion of your soul's sickness that inhibits and binds you, or the social influences around you, or the habits that have created synaptic bonds and pathways in your brain. And then there's advertising, propaganda, and paradigms. Inside that confluences of multifaceted inhibitors," she sighed, "what is freedom really?
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William Paul Young (The Shack)
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Money and time spent for training will be ineffective unless inhibitors to good work are removed.
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W. Edwards Deming (Out of the Crisis)
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Tell me dear, what do you know about prescribing atypical antipsychotics to enchance the effect of selective serotonin reuptake inhibitors?
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Sherrie R. Cronin (y1)
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Fear is the enemy of learning. It’s the negator of joy, the preventer of play, the inhibitor of trust and love. Fear just gets in the way, slows things down, and causes unnecessary pain.
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Karen Pryor (Reaching the Animal Mind)
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(about William Blake)
[Blake] said most of us mix up God and Satan. He said that what most people think is God is merely prudence, and the restrainer and inhibitor of energy, which results in fear and passivity and "imaginative death."
And what we so often call "reason" and think is so fine, is not intelligence or understanding at all, but just this: it is arguing from our *memory* and the sensations of our body and from the warnings of other people, that if we do such and such a thing we will be uncomfortable. "It won't pay." "People will think it is silly." "No one else does it." "It is immoral."
But the only way you can grow in understanding and discover whether a thing is good or bad, Blake says, is to do it. "Sooner strangle an infant in its cradle than nurse unacted desires."
For this "Reason" as Blake calls it (which is really just caution) continually nips and punctures and shrivels the imagination and the ardor and the freedom and the passionate enthusiasm welling up in us. It is Satan, Blake said. It is the only enemy of God. "For nothing is pleasing to God except the invention of beautiful and exalted things." And when a prominent citizen of his time, a logical, opining, erudite, measured, rationalistic, Know-it-all, warned people against "mere enthusiasm," Blake wrote furiously (he was a tender-hearted, violent and fierce red-haired man): "Mere enthusiasm is the All in All!
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Brenda Ueland (If You Want to Write: A Book about Art, Independence and Spirit)
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When a lobster that has just lost a battle is exposed to serotonin, it will stretch itself out, advance even on former victors, and fight longer and harder.9 The drugs prescribed to depressed human beings, which are selective serotonin reuptake inhibitors, have much the same chemical and behavioural effect. In one of the more staggering demonstrations of the evolutionary continuity of life on Earth, Prozac even cheers up lobsters.
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Jordan B. Peterson (12 Rules for Life: An Antidote to Chaos)
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The strength of Trump’s populist language lies in its openness: ‘It requires no expert knowledge… It’s the way people talk when the inhibitors are off.
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Amanda Montell (Cultish: The Language of Fanaticism)
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The pew is perhaps the greatest inhibitor of face-to-face fellowship. It is a symbol of lethargy and passivity in the contemporary church and has made corporate worship a spectator sport.
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Frank Viola (Pagan Christianity?: Exploring the Roots of Our Church Practices)
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Sometimes the psychiatric drugs themselves are a factor as withdrawal from selective seratonin reuptake inhibitors (SSRIs) can be particularly unpleasant. British psychiatrist Dr. David Healy notes that “almost all the school shooters that we know of have either been on or using these drugs or in withdrawal from them,” a condition called SSRI discontinuation syndrome.
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Jim Marrs (Population Control: How Corporate Owners Are Killing Us)
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I am finally awarded selective serotonin reuptake inhibitors for all my hard work as a depressed person. I am waiting for the pharmacist to fill my prescription, and to present me with my medal. Thank you to Dr. Chan for nominating me for this honor, and my brain for burdening me.
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Emily R. Austin (Everyone in This Room Will Someday Be Dead)
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The inhibition of an inhibitor leads to the activation of an inhibitor of an inhibitory pathway. This is the point where most people might be tempted to give up on biochemistry!
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Chris Cooper (Run, Swim, Throw, Cheat: The Science Behind Drugs in Sport)
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Empathy is the prime inhibitor of human cruelty: withholding our natural inclination to feel with another allows us to treat the other as an It.
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Daniel Goleman (Social Intelligence: The New Science of Human Relationships)
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the biggest inhibitor to change lies within yourself, and
that nothing gets better until you. change.
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Spencer Johnson (Who Moved My Cheese? An Amazing Way to Deal with Change in Your Work and in Your Life...)
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Psychotropic drugs have also been organized according to structure (e.g., tricyclic), mechanism (e.g., monoamine, oxidase inhibitor [MAOI]), history (first generation, traditional), uniqueness (e.g., atypical), or indication (e.g., antidepressant). A further problem is that many drugs used to treat medical and neurological conditions are routinely used to treat psychiatric disorders.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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We worship entertainment as much as technology, and there's nothing less entertaining than grief. That's why God invented lorazepam, and selective serotonin reuptake inhibitors, and vodka and television - which in my experience work best in combination, with a pizza.
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Tom Jokinen (Curtains: Adventures of an Undertaker-in-Training)
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selective serotonin reuptake inhibitor (SSRI) and serotonin–norepinephrine reuptake inhibitors (SNRIs) are now used as primary treatments, with benzodiazepines used as adjuncts. Benzodiazepine abuse is rare, usually found in patients who abuse multiple prescription and recreational drugs.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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Women can get depressed before their period, but PMS is not just depression. Yet PMS is often considered by medical doctors and pharmaceutical companies to be a psychiatric condition suitable for treatment with selective serotonin reuptake inhibitors such as fluoxetine (Prozac, Serafem). But
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Carolyn Dean (The Magnesium Miracle (Revised and Updated))
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Caffeine has a calming effect on the ADHD brain. The theory is that the brain of people who suffer from the disorder has an overabundance of dopamine transporters, or re-uptake inhibitors. They carry away dopamine too fast, creating a shortage of it. In turn, that affects serotonin and norepinephrine. The combined effect is a reduced ability to focus, especially on tasks that the person doesn’t enjoy, a lesser ability to control impulsivity, and it even messes with the awareness of time. Caffeine stimulates dopamine production in the brain, temporarily filling up the gap created by the rapid
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I.T. Lucas (Dark Memories Submerged (The Children of the Gods, #53))
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Shame and fear are the most potent and universal emotional inhibitors. I cannot experience love if it smacks of the probability of rejection or augurs my inability to sustain it. I cannot experience sufficient interest to achieve my fullest potential if I sense the shame of failure or the risk of harm, deprivation, or isolation.
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Steven Stosny (The Laws of Emotion and Meaning)
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we take our victories where we find them, and accept our defeats with grace and patience.
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Alastair Reynolds (Inhibitor Phase (Revelation Space, #4))
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The idea that depression is caused by low serotonin levels in the brain is now deeply embedded in popular folklore, and people with no neuroscience background at all will routinely incorporate phrases about it into everyday discussion of their mood, just to keep their serotonin levels up. Many people also don't know that this is how antidepressant drugs work: depression is caused by low serotonin, so you need drugs which raise the serotonin levels in your brain, like SSRI antidepressants, which are 'selective serotonin reuptake inhibitors'. But this theory is wrong. The 'serotonin hypothesis' for depression, as it is known, was always shaky, and the evidence now is hugely contradictory ... But in popular culture the depression-serotonin theory is proven and absolute, because it has been marketed so effectively.
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Ben Goldacre (Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients)
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When I interviewed with the Chief of Family Medicine at a large medical corporation on the West Coast, he explained that, since he was part of a team of people who arranged for pharmaceutical companies to issue cash grants, he was in a position to offer me a particularly enticing salary. “What are the grants for?” I asked. “We have a quality improvement program that tracks physician prescribing patterns. We call it ‘quality’ but it’s really about money.” And that’s all it’s about. It works like this. In his organization, any patient with LDL cholesterol over 100 is put on a cholesterol-lowering medication. Any person with a blood pressure higher than 140/90 is put on a blood pressure medication. Any person with “low bone density” is put on a bone-remodeling inhibitor. And so on. The doctors who prescribe the most get big bonuses. Those who prescribe the least get fired. With a hint of incredulousness in his voice, he explained, “So far, every time we’ve asked for funding for our program, the drug companies give it to us.” If this is where healthcare is headed, then these hybrid physicians-executives will instinctively turn their gaze to our children and invent more creative methods to bulldoze an entire generation into the bottomless pit of chronic disease.
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Catherine Shanahan (Deep Nutrition: Why Your Genes Need Traditional Food)
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Medications used to treat psychiatric disorders are commonly referred to as psychotropic drugs. These drugs are commonly described by their major clinical application, for example, antidepressants, antipsychotics, mood stabilizers, anxiolytics, hypnotics, cognitive enhancers, and stimulants. A problem with this approach is that these drugs have multiple indicators. For example, selective serotonin reuptake inhibitors (SSRls) are both antidepressants and anxiolytics, and the serotonin-dopamine antagonists (SDAs) are both anxiolytics and mood stabilizers.
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Benjamin James Sadock (Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry)
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The drugs used most often to treat depression are the so-called selective serotonin reuptake inhibitors such as Prozac, Paxil, and Celexa. These drugs boost the activity of the serotonin signaling system, which psychiatry had long thought is exclusively located in the brain. However, we know today that 95 percent of the body’s serotonin is actually contained in specialized cells in the gut, and these serotonin-containing cells are influenced by what we eat, by chemicals released from certain species of gut microbes, and by signals that the brain sends to them, informing them about our emotional state.
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Emeran Mayer (The Mind-Gut Connection: How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Overall Health)
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So should patients born under Libra and Gemini be deprived of treatment? You would say no, of course, and that would make you wiser than many in the medical profession: the CCSG trial found that aspirin was effective at preventing stroke and death in men, but not in women;30 as a result, women were undertreated for a decade, until further trials and overviews showed a benefit. That is just one of many subgroup analyses that have misled us in medicine, often incorrectly identifying subgroups of people who wouldn’t benefit from a treatment that was usually effective. So, for example, we thought the hormone-blocking drug tamoxifen was no good for treating breast cancer in women if they were younger than fifty (we were wrong). We thought clotbusting drugs were ineffective, or even harmful, when treating heart attacks in people who’d already had a heart attack (we were wrong). We thought drugs called ‘ACE inhibitors’ stopped reducing the death rate in heart failure patients if they were also on aspirin (we were wrong). Unusually, none of these findings was driven by financial avarice: they were driven by ambition, perhaps; excitement at new findings, certainly; ignorance of the risks of subgroup analysis; and, of course, chance.
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Ben Goldacre (Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients)
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The researchers tried a clever tactic to overcome this problem. They created a number of recipes for common foods including muffins and pasta in which they could disguise placebo ingredients like bran and molasses to match the texture and color of the flax-laden foods. This way, they could randomize people into two groups and secretly introduce tablespoons of daily ground flaxseeds into the diets of half the participants to see if it made any difference. After six months, those who ate the placebo foods started out hypertensive and stayed hypertensive, despite the fact that many of them were on a variety of blood pressure pills. On average, they started the study at 155/81 and ended it at 158/81. What about the hypertensives who were unknowingly eating flaxseeds every day? Their blood pressure dropped from 158/82 down to 143/75. A seven-point drop in diastolic blood pressure may not sound like a lot, but that would be expected to result in 46 percent fewer strokes and 29 percent less heart disease over time.125 How does that result compare with taking drugs? The flaxseeds managed to drop subjects’ systolic and diastolic blood pressure by up to fifteen and seven points, respectively. Compare that result to the effect of powerful antihypertensive drugs, such as calcium-channel blockers (for example, Norvasc, Cardizem, Procardia), which have been found to reduce blood pressure by only eight and three points, respectively, or to ACE inhibitors (such as Vasotec, Lotensin, Zestril, Altace), which drop patients’ blood pressure by only five and two points, respectively.126 Ground flaxseeds may work two to three times better than these medicines, and they have only good side effects. In addition to their anticancer properties, flaxseeds have been demonstrated in clinical studies to help control cholesterol, triglyceride, and blood sugar levels; reduce inflammation, and successfully treat constipation.127 Hibiscus Tea for Hypertension Hibiscus tea, derived from the flower of the same name, is also known as roselle, sorrel, jamaica, or sour tea. With
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Michael Greger (How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease)
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Sourdough isn't only for bread. Any grain-based baked good- from crackers to waffles, from muffins to pasta, can be made with a wild yeast starter. Why would the home baker want to incorporate sourdough into their regular baking? First, it's an excellent way to use the starter you remove during feedings. Instead of throwing the excess in the trash, add it to your pancake batter or chocolate chip cookies. Second, a sourdough starter is an ecosystem of wild yeasts and beneficial bacteria that work together to add B-vitamins to grains, to break down gluten for better digestion, and to neutralize phytic acid and enzyme inhibitors. In other words, it's good for you. And finally, because sourdough eventually becomes a way of life. Experimenting with different ways of using it is one of the most satisfying aspects of using wild yeast in your kitchen.
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Christa Parrish (Stones For Bread)
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Nu m-am gândit niciodată serios să am de-a face cu o prostituată. Nu vreau să par ipocrit. Sunt un bărbat ca oricare altul. Nivelul de hormoni androgeni din sângele meu este de zece ori mai ridicat decât în sângele unei femei. Creierul meu este scăldat în hormoni sexuali. Simt de multe ori din plin neliniştea erotică pură, mă excită de multe ori o necunoscută dintr-un autobuz, mă rătăcesc adesea în labirintul fanteziilor violente şi-ntunecate, populate tocmai de asemenea obiecte sexuale, total aservite voinţei mele. Pornografia nu mă dezgustă întotdeauna — îmi asum ca bărbat zecile de mii de site-uri de pe internet şi sutele de reviste pe care nici o femeie nu le-ar cumpăra — şi sunt momente când am o nevoie imperioasă de imagini orgiastice. Cu toate acestea, am regretat de câte ori am făcut dragoste cu o femeie străină şi indiferentă, şi pentru nimic în lume n-aş face dragoste cu o prostituată. Nu pentru că riscurile sunt mari şi nici pentru că fidelitatea nu mi-o permite. Cred, pur şi simplu, că sexul însoţit de intimitate este mai bun decât cel fără intimitate. Intenţionat nu vorbesc despre dragoste, deşi până la urmă despre asta e vorba. Dragostea ca sentiment este uneori un inhibitor al sexualităţii, iar fidelitatea devine greu de suportat în pat. Sexul implică o profundă îngustare a conştiinţei, o coborâre adânc sub convenţiile sociale şi etice, o eliberare de tabu-uri, de dezgust, o căutare a plăcerii în interzis şi perversiune. Dragostea, cu puternica ei componentă culturală, tinde şi ea să fie înlăturată în cele mai intense momente ale actului sexual, ca parte a carapacei cerebrale ce ne acoperă nuditatea; în multe cupluri fantezia depersonalizării partenerilor, a uitării legăturii dintre ei, intensifică plăcerea erotică. Cu toate acestea, ceva din această legătură psihică dintr-un cuplu adevărat, numită dragoste, ceva esenţial şi despre care se vorbeşte prea puţin, supravieţuieşte şi celei mai devastatoare dezgoliri simbolice. Este, ca să zic aşa, iubirea intensă dintre două corpuri. Chiar şi când minţile şi personalităţile sunt dizolvate în plăcerea irepresibilă a sexualităţii, intimitatea rămâne şi dă actului acestuia violent şi animalic ceva copilăros, înduioşător, ceva pe care ţi-l aminteşti, după ce ai uitat plăcerea, ca pe adevărata bucurie a acelor ore. Cum nu dau doi bani pe fanteziile puse-n practică (pentru că, concretizate, ele îşi pierd tocmai idealitatea: pot fantaza despre un sex party, de pildă, dar unul real trebuie că e dezamăgitor printr-o mulţime de amănunte concrete), la fel un act sexual în care corpurile nu se cunosc mi se pare ratat de la bun început.
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Mircea Cărtărescu (De ce iubim femeile)
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Huperzia serrata Native to India and Southeast Asia, the Huperzia serrata is also called firmoss. It is used in Chinese and Ayurvedic medicine as medicinal plants to treat different types of maladies. In recent studies, researchers have found out that it contains neuro-protective properties. Benefits Unlike other medicinal herbs in Asia, Huperzia serrata is not as common in Western folk medicine. This particular herb contains the compound called huperzine A which is an acetylcholinesterase inhibitor and NMDA receptor antagonist. Below are the benefits of using this medicinal herb. It is used to improve the brain and cognitive function. It can also help prevent the occurrence of autoimmune neuromuscular diseases that can lead to muscle weakness and disability. It has the potential of treating patients suffering from Alzheimer’s disease. How to Use This particular medicinal herb is prepared as tea or infusion. However, there are also dietary supplements available from the market that you can take.
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Jeff Robson (Medicinal Herbs: The Ultimate Guide to Medical Herbs that Heal)
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The fact is that the individual, though its genotypic sex is fixed at fertilisation, can be profoundly affected by the environment in which it develops. In the ants, bees, and termites the larval nutrition determines whether the genotypic female individual will become a fully developed female (‘queen’) or a sexually retarded worker. In these cases the whole organism is affected; but the gonads do not play a part in establishing the sexual differences of the body, or soma. In the vertebrates, however, the hormones secreted by the gonads are the essential regulators. Numerous experiments show that by varying the hormonal (endocrine) situation, sex can be profoundly affected. Grafting and castration experiments on adult animals and man have contributed to the modern theory of sexuality, according to which the soma is in a way identical in male and female vertebrates. It may be regarded as a kind of neutral element upon which the influence of the gonad imposes the sexual characteristics. Some of the hormones secreted by the gonad act as stimulators, others as inhibitors. Even the genital tract itself is somatic, and embryological investigations show that it develops in the male or female direction from an indifferent and in some respects hermaphroditic condition under the hormonal influence. Intersexuality may result when the hormones are abnormal and hence neither one of the two sexual potentialities is exclusively realised.
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Simone de Beauvoir (The Second Sex)
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To take advantage of our maladaptive emotions we should create a list of small actionable steps that gradually expose us to the situations we fear. Each step should take us progressively further out of our comfort zone but if we can commit to taking at least one step each day we will have turned our maladaptive emotions from inhibitors of our well-being to promoters of a stronger self. When a distressing emotion is triggered through this exercise we merely need to label it, accept it, and then move forward regardless of how uncomfortable we feel. If we are consistent in our practice we will likely notice that our maladaptive emotions arise with diminished frequency. But even if they continue to be part of our life this exercise will teach us that distressing emotions need not be chains that limit us and that action can be taken even in their presence. We will have learned, in other words, the art of acting with courage.
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Academy of Ideas
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The antibody, now a potential drug, would soon be renamed Herceptin, fusing the words Her-2, intercept, and inhibitor.
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Siddhartha Mukherjee (The Emperor of All Maladies: A Biography of Cancer)
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recent paper describes a clinical trial where a platinum-based chemotherapy was used in combination with a checkpoint inhibitor, resulting in improved overall survival in patients with lung cancer.
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Peter Attia (Outlive: The Science and Art of Longevity)
Brandon Sanderson (Defiant (Skyward, #4))
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Sometimes the only thing standing between you and your desires, your goals, is you; we can be our own greatest inhibitors, but in understanding that our situations are consequential, and not merely circumstantial, you can start to take the first steps in taking control and bringing outcomes that sit well with your heart, everything else will fall into place in their due time and some very beautiful, enlightening revelations can come to light.
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Sayed H Fatimi
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For the writer the conscious mind may be the great inhibitor, the great censor. This conscious mind is created by social mores, education, environment, family pressures, and conventions. For creativity it is necessary to work with the unconscious which accumulates pure experience, reactions, impressions, intuitions, images, memories—an unconscious freed from the negative effect of societal evaluations. The conscious mind can only act later as critic, selector, discarder.
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Anaïs Nin (The Novel of the Future)
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Dr. Lantos had opened her packet, and said, “Prophylactic measures?” “Yes. The blue one’s a standard anti-influenza drug; you’ll need to take it every day for the next six days, whether we’re still working here or not. The white one is a neuraminidase inhibitor that’s shown both preventative and therapeutic results in trials done at the AFIP.” “I never heard of these trials,” Lantos said, examining the white capsule skeptically. “The results haven’t been made public yet. And tomorrow,” he said, with a grin, “may be the best field test we’ve ever run.” “So we are the guinea pigs?” Kozak said. Slater nodded and washed one of each of the pills down with the last of his coffee. Kozak and Lantos did the same, but Nika sat silently, waiting.
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Robert Masello (The Romanov Cross)
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The glucosamine sulphate it turned out was a good thing. It’s a great prebiotic, excellent for maintaining a healthy gut, a fact that is still largely unknown and I was to discover it is also a matrix metalloproteinase inhibitor (more on this later, but in short, it helps halt progression). But I realise with the benefit of hindsight that I may have fuelled
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Jane McLelland (How to Starve Cancer ...without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions)
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The main prescription mix that experts warn against is combining psilocybin with antidepressants like SSRIs and serotonin-norepinephrine reuptake inhibitors (SNRIs) (some popular brand names include Prozac, Zoloft, Paxil, Lexapro, Cymbalta, and Effexor). That’s because these drugs also affect the serotonin system, the main receptor system that psilocybin interacts with. Giordano explains that these types of antidepressants already make more serotonin available in the space between nerve cells in the brain. And so, when psilocybin also acts on that system, there’s a risk of essentially “overdosing” on serotonin, known as “serotonin syndrome.
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Michelle Janikian (Your Psilocybin Mushroom Companion: An Informative, Easy-to-Use Guide to Understanding Magic Mushrooms—From Tips and Trips to Microdosing and Psychedelic Therapy)
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Melatonin and Acid Reflux: Melatonin is an indole that is said to cause sleep. It plays a significant role in stimulating the activity of the lower esophageal sphincter so that stomach contents will not back up into the esophagus. This conclusion is based on animal studies as reported by the Life Extension Foundation. Melatonin has been proven effective in healing sores and ulcers in the digestive tract. Its presence in the GI tract through the enterochromaffin cells can prevent and cure irritable bowel syndrome, stomach upset, and dyspepsia. Taking melatonin along with natural food supplements is more effective than proton-pump inhibitors, particularly omeprazole. Chapter 7: Natural Remedies for Acid Reflux, LPR and GERD Organic Honey, Fresh Basil, Holy Basil Tea, and Indian Gooseberry Some of the natural GERD remedies I am going to talk about are natural and holistic food and herbal therapies.
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Jessika Schwab (ACID REFLUX DIET: The Complete Solution to Understand, Heal and Prevent GERD & LPR with a 30-Day Meal Plan and a Cookbook Full of Low Acid Recipes Including Vegan & Gluten-Free)
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The universe won’t do this to us,’ I whispered to myself. ‘It’s indifferent, but it isn’t actually cruel.’
Perhaps I believed myself, for a moment or two.
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Alastair Reynolds (Inhibitor Phase (Revelation Space, #4))
“
And sometimes..
seeking refuge in the
enchanting realm of dreams
to escape the mundane
inhibitors of reality
is the only way.
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Monika Ajay Kaul
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I wished that adults were as capable as children of moving beyond some impasse, letting go of whatever had been intractable only hours or days ago. I envied them that ability to discard their past selves as if they were old, tattered, useless skins.
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Alastair Reynolds (Inhibitor Phase (Revelation Space, #4))
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The serotonin reuptake inhibitors (SSRIs) such as Prozac, Zoloft, Effexor, and Paxil have been most thoroughly studied, and they can make feelings less intense and life more manageable. Patients on SSRIs often feel calmer and more in control; feeling less overwhelmed often makes it easier to engage in therapy.
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Bessel van der Kolk (The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma)
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Here we might think again about Dr. Bruner's cat who was able to "edit out" sound at the ear-drum. These processes must be considered, not vaguely "psychological," but concretely neurological. We receive around 10,000 sensory signals per minute and edit out (probably) more than 9,990 of them, to tune in or concentrate attention on less than 10 signals that seem "important" to us. The other 9,990-plus signals are "unconsciously" classified as "meaningless" or "irrelevant"; they are not "consciously" suppressed because they never reach the "conscious" centers of the brain. (It is extremely likely that, if the majority of sensory signals did reach the "conscious" centers, we would be so overwhelmed with data that we could not act at all. It seems plausible to think that the mechanism of psychedelic drugs involves inhibiting inhibitors — turning on circuits that are habitually turned off — and the subject is, then, perceiving, maybe, 20 to 100 signals a minute instead of the usual 10. This itself is startling enough to produce hilarious laughter, profound awe or acute anxiety, especially on first dosage.)
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Robert Anton Wilson (The New Inquisition: Irrational Rationalism and the Citadel of Science)
Emily Nagoski (Come As You Are: The Surprising New Science That Will Transform Your Sex Life)
“
place. Inhibitors Sometimes I have so many worries that I am unable to get aroused. 0 1 2 3 4 Not at all like me Not much like me Somewhat like me A lot like me Exactly like me Unless things are “just right,” it is difficult for me to become sexually aroused. 0 1 2 3 4 Not at all like me Not much like me Somewhat like me A lot like me Exactly like me If I am uncertain how my partner feels about me, it is harder for me to get aroused. 0 1 2 3 4 Not at all like me Not much like me Somewhat like me A lot like me Exactly like me If I am worried about taking too long to become aroused or to orgasm, this can interfere with my arousal. 0 1 2 3 4 Not at all like me Not much like me Somewhat like me A lot like me Exactly like me Sometimes I feel so “shy” or self-conscious during sex that I cannot become fully aroused. 0 1 2 3 4 Not at all like me Not much like me Somewhat like me A lot like me Exactly like me Total (out of 20) ____
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Emily Nagoski (Come As You Are: The Surprising New Science That Will Transform Your Sex Life)
“
Then there’s Prozac. It is so new at this point that Dr. Sterling still refers to it as fluoxetine. Prozac, like Zoloft, Paxil, and other drugs of its type which were not yet available as I lay in Stillman in 1988, acts only on serotonin. It is very pure in its chemical objectives. Its drug family will come to be known as selective serotonin reuptake inhibitors (SSRIs), and it can act very powerfully and directly within its narrow domain. Since fluoxetine’s aims are less scattershot than those of its predecessors, it tends to have fewer side effects.
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Elizabeth Wurtzel (Prozac Nation: Young and Depressed in America)
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But the medicalization of chronic disease in the past fifty years has been an abject failure. Today, we’ve siloed diseases and have a treatment for everything: High cholesterol? See a cardiologist for a statin. High fasting glucose? See an endocrinologist for metformin. ADHD? See a neurologist for Adderall. Depressed? See a psychiatrist for a selective serotonin reuptake inhibitor (SSRI). Can’t sleep? See a sleep specialist for Ambien. Pain? See a pain specialist for an opioid. PCOS? See an OB-GYN for clomiphene. Erectile dysfunction? See a urologist for Viagra. Overweight? See an obesity specialist for Wegovy. Sinus infections? See an ENT for an antibiotic or surgery. But what nobody talks about—what I think many doctors don’t even realize—is that the rates of all these conditions are going up at the exact time we are spending trillions of dollars to “treat them.
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Casey Means (Good Energy: The Surprising Connection Between Metabolism and Limitless Health)
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the eternal awkwardness of the drawn-out farewell.
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Alastair Reynolds (Inhibitor Phase (Revelation Space, #4))
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such a lie is unloving. In the name of caring about her, your lie became an inhibitor in your relationship with her,
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William Paul Young (The Shack)
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the absorption of most nutrients is dependent on or influenced by the presence of other nutrients. Nutrient enhancers can keep a nutrient soluble or protect it from nutrient inhibitors. For example, beta-carotene, lutein, and lycopene are fat soluble, which means they require fat for optimal assimilation, so adding an avocado to a green salad (increasing its fat content by 47 percent) can help you absorb seven times more lutein and eighteen times more beta-carotene.
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Chris Kresser (The Paleo Cure: Eat Right for Your Genes, Body Type, and Personal Health Needs—Prevent and Reverse Disease, Lose Weight Effortlessly, and Look and Feel Better than Ever)
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Eventually, science finds a cure: polio, smallpox, measels, whooping cough, rinderpest (look it up), all gone. Eventually, those ladies and gents in the white lab coats wielding pipettes will get around to the debilitating condition known as Writer's Block.
Imagine if Big Pharma spent $1 Billion and 14 years of R&D effort, just like they do on allergy medicine and mood lifters: "Ask your doctor if Narrativa is right for you. Narrativa is a fast-flow, editor-inhibitor (FFEI) that works in your bloodstream to initiate poetry, prose, and young adult fiction. Side effects of Narrativa include job loss, missed meals, laptop battery wear, comma splices, and of course, death. For impoverished literary journal writers and creative writing program faculty adjuncts, Pfizer may be willing to subsidize the cost of your Narrativa dosing.
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Jon Obermeyer
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It was true Advils looked just like little brown M&M's. Motrin, in the right light, were SweetTarts. A band of MAO inhibitor called Nardil looked just like the tiny round Red Hots we'd all eaten as children.
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David Foster Wallace (Girl with Curious Hair)
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Twice in a year and a half, I had undergone two complete transformations of my so-called self. First, my conscious self was transformed into something other than it previously had been by psychedelic drugs. Then, a year and a half later, my original self was restored, this time by a drug known as a monoamine oxidase inhibitor (MAOI).
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Matthew Alper (The "God" Part of the Brain: A Scientific Interpretation of Human Spirituality and God)
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Imagine you have a kitchen sink in your brain. The faucet drips serotonin into the sink, where it sits, waiting to be used by your brain to help keep things steady—your mood, libido, energy, anxiety control, pain control, concentration, sleep and appetite, to name a few. The sink also has a garbage disposal that grinds up the serotonin and recycles some of the parts back up to the faucet to make more serotonin. Some of the key ingredients for making and regulating serotonin are Zinc, Inositol, Vitamin B6, Folate and a form of tryptophan called 5HTP. If you don’t have enough of these key ingredients, your serotonin production goes down, or your faucet drips much more slowly than your garbage disposal is grinding. That will cause a drop in your serotonin levels. I will talk later about ways to increase the rate of your serotonin production or “turn the faucet up higher” by getting more of the key ingredients to your brain. The other way to manipulate serotonin levels is by putting a stopper in your garbage disposal with a type of medication called an SSRI-selective serotonin reuptake inhibitor. No,
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Raphael Allred (Happy Naturally: A Quick Guide to Supplements and Self-Help Tools for Depression and Anxiety)
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The body’s initial response to a noxious local insult is to produce a local inflammatory response with sequestration and activation of white blood cells and the release of a variety of mediators to deal with the primary ‘insult’ and prevent further damage either locally or in distant organs. Normally, a delicate balance is achieved between pro- and anti-inflammatory mediators. However, if the inflammatory response is excessive, local control is lost and a large array of mediators, including prostaglandins, leukotrienes, free oxygen radicals and particularly pro-inflammatory cytokines (p. 72), are released into the circulation. The inflammatory and coagulation cascades are intimately related. The process of blood clotting not only involves platelet activation and fibrin deposition but also causes activation of leucocytes and endothelial cells. Conversely, leucocyte activation induces tissue factor expression and initiates coagulation. Control of the coagulation cascade is achieved through the natural anticoagulants, antithrombin (AT III), activated protein C (APC) and tissue factor pathway inhibitor (TFPI), which not only regulate the initiation and amplification of the coagulation cascade but also inhibit the pro-inflammatory cytokines. Deficiency of AT III and APC (features of disseminated intravascular coagulation (DIC)) facilitates thrombin generation and promotes further endothelial cell dysfunction. Systemic inflammation During a severe inflammatory response, systemic release of cytokines and other mediators triggers widespread interaction between the coagulation pathways, platelets, endothelial cells and white blood cells, particularly the polymorphonuclear cells (PMNs). These ‘activated’ PMNs express adhesion factors (selectins), causing them initially to adhere to and roll along the endothelium, then to adhere firmly and migrate through the damaged and disrupted endothelium into the extravascular, interstitial space together with fluid and proteins, resulting in tissue oedema and inflammation. A vicious circle of endothelial injury, intravascular coagulation, microvascular occlusion, tissue damage and further release of inflammatory mediators ensues. All organs may become involved. This manifests in the lungs as the acute respiratory distress syndrome (ARDS) and in the kidneys as acute tubular necrosis (ATN), while widespread disruption of the coagulation system results in the clinical picture of DIC. The endothelium itself produces mediators that control blood vessel tone locally: endothelin 1, a potent vasoconstrictor, and prostacyclin and nitric oxide (NO, p. 82), which are systemic vasodilators. NO (which is also generated outside the endothelium) is implicated in both the myocardial depression and the profound vasodilatation of both arterioles and venules that causes the relative hypovolaemia and systemic hypotension found in septic/systemic inflammatory response syndrome (SIRS) shock. A major component of the tissue damage in septic/SIRS shock is the inability to take up and use oxygen at mitochondrial level, even if global oxygen delivery is supranormal. This effective bypassing of the tissues results in a reduced arteriovenous oxygen difference, a low oxygen extraction ratio, a raised plasma lactate and a paradoxically high mixed venous oxygen saturation (SvO2). Role of splanchnic ischaemia In shock, splanchnic hypoperfusion plays a major role in initiating and amplifying the inflammatory response, ultimately resulting in multiple organ failure (MOF). The processes involved include: • increased gut mucosal permeability • translocation of organisms from the gastrointestinal tract lumen into portal venous and lymphatic circulation • Kupffer cell activation with production and release of inflammatory mediators.
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Nicki R. Colledge (Davidson's Principles and Practice of Medicine (MRCP Study Guides))
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3.5 A 45-year-old woman is noted to have dizziness, pounding of the chest, and fatigue of 3 hours’ duration. On examination, she is noted to have a blood pressure (BP) of 110/70 mm Hg and heart rate of 180 bpm. She is noted on ECG to have atrial fibrillation, and a prior baseline ECG showed delta waves. The ER physician counsels the patient regarding cardioversion, but the patient declines. Which of the following is the best therapy for her condition? A. Digoxin B. Angiotensin-converting enzyme (ACE) inhibitor C. Calcium channel blocker D. Procainamide
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Eugene C. Toy (Case Files: Internal Medicine)
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molecularly targeted agents into the treatment of early-stage NSCLC. At this time, however, such an approach cannot be recommended outside a clinical trial. In the NCI-C JBR.19 trial, which was terminated early when gefitinib lost its U.S. Food and Drug Administration (FDA) approval, administration of the EGFR inhibitor gefitinib after resection of stage I to III NSCLC did not improve OS. Surprisingly, a subset analysis of patients with tumors harboring activating EGFR mutations, a population expected to derive particular benefit from such an approach, suggested the possibility of a detrimental effect from gefitinib. Similarly, the use of antiangiogenic agents and ALK inhibitors after surgery for advanced disease remains investigational.
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Anonymous
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Other important alterations to the genetic code involve so-called promoters and inhibitors, pieces of genes that regulate the gene’s ability to make products. Some of these products regulate the behavior of neurotransmitters. So promoters and inhibitors are like the gas and brake pedals of a gene as they control the delivery of neurotransmitters like serotonin and dopamine in the brain. For serotonin, implicated in depression, bipolar disorder, sleep and eating disorders, schizophrenia, hallucinations and panic attacks, as well as psychopathy, the breakdown enzyme is MAO-A. MAOA, the gene that produces this enzyme (and lacks its hyphen), has a promoter that comes in either a short form or a long form. The version of the MAOA gene with the short promoter has been associated with aggressive behavior and is called the “warrior gene.
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James Fallon (The Psychopath Inside: A Neuroscientist's Personal Journey into the Dark Side of the Brain)
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Does freedom mean that you are allowed to do whatever you want to do? Or we could talk about all the limiting influences in your life that actively work against your freedom. Your family genetic heritage, your specific DNA, your metabolic uniqueness, the quantum stuff that is going on at a subatomic level where only I am the always-present observer. Or the intrusion of your soul’s sickness that inhibits and binds you, or the social influences around you, or the habits that have created synaptic bonds and pathways in your brain. And then there’s advertising, propaganda, and paradigms. Inside that confluence of multifaceted inhibitors,” she said, sighing, “what is freedom really?
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William Paul Young (The Shack)
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Not being able to forgive yourself for your boneheaded, arrogant, and selfish actions is one of the biggest inhibitors to living the life God most wants you to live.
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Stephen F. Arterburn (Regret-Free Living: Hope for Past Mistakes and Freedom From Unhealthy Patterns)
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BUYER’S MATRIX Position: Roles/Responsibilities: What are they in charge of or expected to manage? Business Objectives and Metrics: What do they want to achieve? How do they measure success? How are they evaluated? Strategic Initiatives: What likely strategies and initiatives are in place to help them achieve their objectives? Internal Challenges: What likely issues does the organization face that could prevent/hinder goal achievement? External Challenges: What external factors or industry trends might make it more difficult to reach their objectives? Primary Interfaces: Who do they frequently interact with (e.g., peers, subordinates, superiors, and external resources)? Status Quo: What’s their status quo relative to your product or service? Change Drivers: What would cause them to change from what they’re currently doing? Change Inhibitors: What would cause them to stay with the status quo, even if they’re unhappy?
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Jill Konrath (Agile Selling: Get Up to Speed Quickly in Today's Ever-Changing Sales World)
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Activation of the androgen receptor (AR) is crucial for tumor cell progression and survival of prostate cancer, and androgen deprivation therapy remains the main clinical approach in men with locally advanced tumors ■ Current therapies incompletely suppress the androgen–AR axis, but a multiple therapeutic approach, targeting androgens and their receptor, has potential to improve clinical outcomes ■ Treatment of prostate cancer cells with 5α-reductase inhibitors (5ARIs) inhibits cellular pathways regulating metabolism, cell growth and proliferation, triggering apoptosis and decreasing prostate size ■ Although 5ARI treatment reduces the risk of developing prostate cancer, patients treated with these drugs have tumors with higher Gleason scores than those who receive placebo ■ Use of 5ARIs to prevent and treat prostate cancer remains controversial, and further investigation is necessary to understand the presence of more-aggressive tumors in patients receiving these drugs
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Anonymous
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soy beans contain potent enzyme inhibitors that cause intestinal problems, cancer and growth retardation. Soy is also high in phytic acid, which blocks the absorption of essential minerals, such as iron, calcium, magnesium and zinc.
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Sally Fallon Morell (Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats)
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the topic of cholesterol, magnesium appears to play a potentially beneficial role here as well, by functioning as a kind of natural statin. The synthesis of cholesterol in your body requires an enzyme known as HMG-CoA reductase. Statins, which are also known as HMG-CoA reductase inhibitors, work by inhibiting this process. So in cases where there is heightened risk of heart disease or medically-diagnosed hypercholesterolemia (pathologically high levels of LDL cholesterol), magnesium may provide similar protection as statins
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James Lee (Just Keep Calm & Take Some Magnesium - Why a “boring” mineral is suddenly hot property for soothing bodies and calming minds)
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4 The Culture of Do and Tell The main inhibitor of Humble Inquiry is the culture in which we grew up. Culture can be thought of as manifesting itself on many levels—it is represented by all of its artifacts, by which I mean buildings, art works, products, language, and everything that we see and feel when we enter another culture.
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Edgar H. Schein (Humble Inquiry: The Gentle Art of Asking Instead of Telling)
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b. Procedural Differences Between Consolidation vs. Reconsolidation Studies. In studies of consolidation, typically a protein synthesis inhibitor (a drug known to block consolidation) is given immediately after training. Then short-term memory (STM) is tested. The next day, long-term memory is tested. The typical finding is that STM is intact (showing that the memory was formed) but LTM is impaired (indicating that STM was not consolidated into a persistent LTM). In reconsolidation studies, the drug is given after retrieval of a fully consolidated memory. STM and LTM are then tested. The typical finding is that post-retrieval STM is intact (showing that the memory was present during retrieval) but LTM is impaired. The conclusion is that during retrieval, memory is destabilized and has to be reconsolidated via protein synthesis to persist as LTM.
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Joseph E. LeDoux (Anxious)
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Carried further, was it possible that as Medicare budgets dried up—as the population aged and the oft-cited “gray tsunami” landed on American soil—Americans might start to consider rational suicide for the elderly as an act of social responsibility, carried out by older people who understand themselves to be drains on the system and inhibitors of opportunity for the young? Already, about a quarter of Medicare spending each year is directed to patients in their very last year of life.
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Katie Engelhart (The Inevitable: Dispatches on the Right to Die)
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Why chocogra 100 MG succeeds within the USA
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Chocogra 100 mg coordinates a district with an event of answers spoken as pde5 inhibitors. It actually works by means of the use of the usage of loosening up the veins on your hassle. Chocogra 100 mg can in reality assist you with obtaining an associate in nursing erection on the off risk simply which you in reality that you essentially unit in reality restored. It's miles astoundingly precious beside and wishes to be required somewhere close to 1/2 of of-hour in advance than sexual movement. Maximum deferred outcomes not would like the medical thoughts and vanish as your frame adjusts to the drugs. Suggest your phencyclidine assumptive they pressure ahead or walking toward the norm hand the severa event absolutely that you certainly basically unit compelled over them antique difficulty side effect of chocogra 100 mg flushings (vibe of strain the diverse face, ears, neck, and trunk) headache, stiffness, nosebleeds, blurred vision, aftereffect, muscle torment secondary effect, rash
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Meds Arcade
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It impacts the gallbladder by causing contraction and release of stored bile.1 2 3
Milk Thistle (Silybum Marianum) has the ability to increase the solubility of bile and its use has been shown to significantly reduce biliary cholesterol concentrations and bile saturation indexes.4 It has potent antioxidant activity which supports phase I detoxification and prevents the depletion of hepatic glutathione which is important for phase II detoxification.5 6 7 Silybum marianum has anti-inflammatory chemical properties that are inhibitors of inflammatory prostaglandins and leukotriens as well as chemical properties that promote protein synthesis to replace damaged liver cells. 8 9 10 11
Ginger (Zingiber Officinale) contains chemical compounds that have been shown to increase bile secretion and to reduce hepatic cholesterol levels by up-regulating the enzyme cholesterol-7-alpha-hydorxylase which is the rate limiting enzyme in bile acid synthesis.12 13 14
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Datis Kharrazian (Why Do I Still Have Thyroid Symptoms? When My Lab Tests Are Normal: A revolutionary breakthrough in understanding Hashimoto’s disease and hypothyroidism)
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The practice of giving the A allows the teacher to line up with her students in their efforts to produce the outcome, rather than lining up with the standards against these students. In the first instance, the instructor and the student, or the manager and the employee, become a team for accomplishing the extraordinary; in the second, the disparity in power between them can become a distraction and an inhibitor, drawing energy away from productivity and development.
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Rosamund Stone Zander (The Art of Possibility: Transforming Professional and Personal Life)
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The paradox is that the main inhibitor of useful telling is often our own failure to inquire in a way that makes it safe for others to tell us the truth, or at least to share all of what they know.
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Edgar H. Schein (Humble Inquiry: The Gentle Art of Asking Instead of Telling)
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Notch – I never had any of these abnormal cell signals tested in my day, but Notch is now known to be associated with cervical cancer. To combat this, the natural flavonoid luteolin is what you need. 95 Unknowingly I had obtained this naturally in my daily celery-rich vegetable juice although I now cheat and take a supplement as luteolin is also a SREBP-2 inhibitor (see
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Jane McLelland (How to Starve Cancer ...without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions)
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I'm sorry. I didn't mean to... I shouldn't have... I'm sorry, Jay. It's the ghee. All that purified butter clogging my inhibitors.
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Jo Boyle (Cicatrice: New Eyes and Brave)
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To live is better than not to live. Even for a few hours, in the company of friends.
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Alastair Reynolds (Inhibitor Phase (Revelation Space, #4))
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LDL receptors can be upregulated by a class of drugs that we mentioned earlier, called PCSK9 inhibitors, which attack a protein called PCSK9 that degrades LDL receptors. This increases the receptors’ half-life, thus improving the liver’s ability to clear apoB. As a monotherapy they have about the same apoB- or LDL-C-lowering potency as high-dose statins, but their most common use is in addition to statins; the combination of statins plus PCSK9 inhibitors is the most powerful pharmacological tool that we have against apoB.
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Peter Attia (Outlive: The Science and Art of Longevity)
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LDL receptors can be upregulated by a class of drugs that we mentioned earlier, called PCSK9 inhibitors, which attack a protein called PCSK9 that degrades LDL receptors. This increases the receptors’ half-life, thus improving the liver’s ability to clear apoB. As a monotherapy they have about the same apoB- or LDL-C-lowering potency as high-dose statins, but their most common use is in addition to statins; the combination of statins plus PCSK9 inhibitors is the most powerful pharmacological tool that we have against apoB. Alas, statins do not reduce Lp(a), but PCSK9 inhibitors do in most patients, typically to the tune of about 30 percent.
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Peter Attia (Outlive: The Science and Art of Longevity)
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2018, with Mukherjee and Cantley as senior authors, the study found that a combination of a ketogenic diet and PI3K inhibitors improved the responses to treatment of mice that had been implanted with human cancer tumors. The
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Peter Attia (Outlive: The Science and Art of Longevity)
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There’s something wrong with my serotonin levels. I read about selective serotonin reuptake inhibitors, which are antidepressants. Would I have to take antidepressants? Or would I have to reuptake them?
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Tommy Orange (There There)
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The pharmaceutical antidepressants known as selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil), decrease platelet clumping in a different way from NSAIDs. When NSAIDs and SSRIs are taken together, the risk of bleeding increases. Herbal remedies and supplements that affect platelets and should be avoided by those on NSAIDs include danshen (Salvia miltiorrhiza), dong quai (Angelica sinensis), evening primrose oil, and willow bark.
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Andrew Weil (Mind Over Meds: Know When Drugs Are Necessary, When Alternatives Are Better and When to Let Your Body Heal on Its Own)
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Newer antivirals, termed neuraminidase inhibitors (NAIs), include zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs impair the release of newly formed viral particles from infected cells. When first introduced, the NAIs were trumpeted as the treatment of choice for the flu. Experience suggests this was an overstatement. Studies show that NAIs shorten the duration of flu by about one day only. Alongside vaccination, they do appear to help prevent complications in those at risk, but they also have drawbacks. Zanamivir is associated with bronchospasm (wheezing) in individuals with chronic lung problems, while oseltamivir is known to cause dizziness, nausea, and vomiting.
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Andrew Weil (Mind Over Meds: Know When Drugs Are Necessary, When Alternatives Are Better and When to Let Your Body Heal on Its Own)
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just as bacteria have become resistant to antibiotics, the flu virus is beginning to develop resistance to NAIs, specifically to oseltamivir: Spanakis N, Pitiriga V, Gennimata, V, et al. “A review of neuraminidase inhibitor susceptibility in influenza strains.” Expert Rev Anti Infect Ther 2014;12:1325–36. Nitsch-Osuch A, Brydak LB. “Influenza viruses resistant to neuraminidase inhibitors.” ACTA BP 2014;61:505–8. 77:
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Andrew Weil (Mind Over Meds: Know When Drugs Are Necessary, When Alternatives Are Better and When to Let Your Body Heal on Its Own)
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Double boiler or warmer designed for melting wax Food grade thermometer Kitchen scale Dipping can (for tapers) Ladle (for pouring candles) Dowels or bamboo sticks (for supporting the wick while the candle is hardening) Wicking tool or wicking needle (for molded candles) Wick weights (for container candles) Rack to hang dipped candles Mold releasing agent Silicone sealant Cookie sheets or silicone mats to work on Oven mitts UV inhibitor (to prevent discoloration) Glue gun Baking paper
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Josephine Simon (Candle Making: Step-by-Step Guide to Homemade Candles)
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2006, the FDA approved a new class of medications called the dipeptidyl peptidase-4 (DPP-4) inhibitors. These drugs are designed to lower blood glucose by blocking the breakdown of incretins, which are hormones released in the stomach that increase insulin secretion in response to food. High incretin levels stimulate insulin release; however, this insulin response is not sustained and therefore these drugs do not cause weight gain. The risk of hypoglycemia is also low.
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Jason Fung (The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally)
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-2 inhibitors The newest class of medication for type 2 diabetes is the SGLT-2 (sodium-glucose linked transporter) inhibitors. These drugs block the reabsorption of glucose by the kidney, so that it spills out in the urine. This lowers blood sugars, resulting in less insulin production. SGLT-2 inhibitors can lower glucose and insulin levels after a meal by as much as 35 per cent and 43 per cent respectively.21 But what effect do SGLT-2 inhibitors have on weight? Studies consistently show a sustained and significant weight loss in patients taking these drugs.22 Unlike virtually all dietary studies that show an initial weight loss followed by weight regain, this study found that the weight loss experienced by patients on SGLT-2 inhibitors continued for one year and longer.
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Jason Fung (The Obesity Code)
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the incantations which could shatter a mind into ones and zeros; pure number.
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Alastair Reynolds (Chasm City (The Inhibitor Series 2))
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I empty my mind. And do something else that is not related to what I am writing about. Sometimes I take long walks, and focus on being in the present. As I walk, I take note of the rise and fall of the land, the diverse faces of people, the roaming animals, and the sounds coming from cars and motorcycles. Most times when I do this ideas flow to me freely, clearing my imaginative inhibitors.
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Valentine Okolo
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Heaven makes you family, but a new generation of selective serotonin reuptake inhibitors can make you friends.
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Gina Barreca (If You Lean In, Will Men Just Look Down Your Blouse?: Questions and Thoughts for Loud, Smart Women in Turbulent Times)
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Several molecules had already shown some anti-kinase activity (albeit with the coarse profiling tools available at the time). There was the isoquinolinesulfonamide from Hidaka’s work. A group from Japan found that a molecule they named erbstatin inhibited EGFR. A group in Israel, led by Yosef Graziani, showed that quercetin, part of a naturally occurring group of chemicals known as flavones, also affected kinase activity inside some tumor cells. The same had been seen with some isoflavones, which also occurred naturally. And there was staurosporine, the antifungal agent that Levitzki had been exploring as an inhibitor of PKC. The fatal flaw of that compound had been its lack of specificity. Could it be adjusted in a way that led it to one kinase, and one kinase only, inside the cell? The next task was to actually make
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Jessica Wapner (The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment)
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atom, which another atom with an abundance of electrons would stick to as if with glue. Some molecules dissolved in fat rather than water. Inside an oily environment, two chemicals might join together, though such bonds were usually weak. For Zimmermann, these hidden worlds held endless possibilities. Combining molecules together in various ways had led to the creation of plastic, of countless medications, of every synthetic substance. The manmade world was made of chemistry. So was the natural world, for that matter. Surely, Zimmermann thought, there was a way to manipulate some molecules into a kinase-inhibiting drug. The challenge lay in more than creating the perfect shape. To be a good inhibitor, the compound also had to stick to the kinase. Creating that
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Jessica Wapner (The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment)
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In our model, treatment with 5-azacytidine will drive down the DNA methylation for as long as the patients take the drug. Unfortunately, many cancer drugs have serious side-effects and the DNMT inhibitors are no exception. The side effects may eventually become such a problem that the patient has to stop taking the drug. However, the patient’s cancer cells probably still have histone modifications at the tumour suppressor genes. Once the patient stops taking 5-azacytidine, these histone modifications almost certainly start to attract the DNMT enzymes all over again, re-initiating stable repression of gene expression.
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Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
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7 foods that Naturally cleanse your Liver
This article lists the 7 best foods to eat to keep your liver healthy:
1. Garlic
Garlic
Garlic contains sulfur compounds that are essential for supporting the liver and activating liver enzymes that are answerable for flushing out toxins and waste from the body. Garlic additionally contains element, a very important mineral and nutrient that assists in detoxification and supports the ductless gland.
2. Walnuts
These oddly-shaped balmy contain high levels of l-arginine, glutathione, and polyunsaturated fatty acid fatty acids, all of that facilitate to detoxify the liver and support poison elimination. Plus, they're nice for fighting inflammation and supporting the health of the brain.
3. Citrus Fruits
Lemons, limes and grapefruits are all natural sources of water-soluble vitamin and contain several potent antioxidants. Like garlic, citrus fruits have the flexibility to spice up the assembly of liver detoxification enzymes.
4. Turmeric
This unimaginable herb contains a large indefinite amount of antioxidants that facilitate to repair the liver cells, shield against cellular injury and assist in detoxification. Turmeric is especially smart at serving to the liver hospital ward from serious metals and assist in endocrine metabolism. Turmeric conjointly boosts the assembly of gall and improves the health of the bladder.
You can create Associate in nursing array of delectable chuck victimisation turmeric, starting from pumpkin and turmeric soup to “golden ice.”
5. Broccoli
Along with alternative genus Brassica vegetables, like Belgian capital sprouts, cabbage and cauliflower, broccoli contains sulfur compounds, similar to garlic, that facilitate to support the detoxification method and also the health of the liver. In fact, these fibrous veggies will facilitate flush out toxins from your gut, and that they contain compounds that facilitate support the liver in metabolising hormones.
6. Leafy Vegetables
The bitterer, the better! Your liver loves bitter, therefore fill on blow ball, rapini, arugula, leaf mustard and chicory. These foliaceous greens contain varied cleansing compounds that neutralize serious metals, which might abate the liver’s ability to detoxify. Plus, they assist to stimulate digestive fluid flow.
7. Avocado
This unimaginable fruit contains glutathione that may be a powerful inhibitor that helps to guard the liver from incoming waste and toxins. It conjointly assists the liver in eliminating these chemicals from your body and protects against cellular harm.
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Sunrise nutrition hub
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A lobster loser’s brain chemistry differs importantly from that of a lobster winner. This is reflected in their relative postures. Whether a lobster is confident or cringing depends on the ratio of two chemicals that modulate communication between lobster neurons: serotonin and octopamine. Winning increases the ratio of the former to the latter. A lobster with high levels of serotonin and low levels of octopamine is a cocky, strutting sort of shellfish, much less likely to back down when challenged. This is because serotonin helps regulate postural flexion. A flexed lobster extends its appendages so that it can look tall and dangerous, like Clint Eastwood in a spaghetti Western. When a lobster that has just lost a battle is exposed to serotonin, it will stretch itself out, advance even on former victors, and fight longer and harder.9 The drugs prescribed to depressed human beings, which are selective serotonin reuptake inhibitors, have much the same chemical and behavioural effect. In one of the more staggering demonstrations of the evolutionary continuity of life on Earth, Prozac even cheers up lobsters.10 High serotonin/low octopamine characterizes the victor. The opposite neurochemical configuration, a high ratio of octopamine to serotonin, produces a defeated-looking, scrunched-up, inhibited, drooping, skulking sort of lobster, very likely to hang around street corners, and to vanish at the first hint of trouble. Serotonin and octopamine also regulate the tail-flick reflex, which serves to propel a lobster rapidly backwards when it needs to escape. Less provocation is necessary to trigger that reflex in a defeated lobster. You can see an echo of that in the heightened startle reflex characteristic of the soldier or battered child with post-traumatic stress disorder.
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Jordan B. Peterson (12 Rules for Life: An Antidote to Chaos)
Joel Fuhrman (Super Immunity: A Comprehensive Nutritional Guide for a Healthier Life, Featuring a Two-Week Meal Plan, 85 Immunity-Boosting Recipes, and the Latest in ... and Nutritional Research (Eat for Life))
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To determine my Nutrient Density Scores, I considered an equal calorie serving of each food. The following nutrients were included in the evaluation: calcium, carotenoids (beta-carotene, alpha-carotene, lutein, zeaxanthin, lycopene), fiber, folate, glucosinolates, magnesium, selenium, vitamin C, vitamin E, zinc, phytosterols, resistant starch, and flavonoids; I also weighed the ORAC score. ORAC (oxygen radical absorbance capacity) is a method of measuring the antioxidant or radical-scavenging capacity of food. Nutrient quantities, which are normally in many different measurements (mg, mcg, IU), were converted to a percentage of their recommended daily intake (RDI) so that a common value could be considered for each nutrient. For nutrients that have no RDI, I established goals based on available research and current understanding of the benefits of these factors. Additional points were added if the food item was anti-angiogenic (more on this later) or contained organosulfides, aromatase inhibitors, or resveratrol. Points were subtracted if the food item contained trans fat or an excessive amount of saturated fat, cholesterol, or sodium, or contained additives as a refined/processed food. The total of the percent RDI or goal for each nutrient, adjusted with added/subtracted points, was then multiplied by a fraction to make the highest number equal 100 so that all foods could be considered on a numerical scale of 1 to 100.
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Joel Fuhrman (Super Immunity: A Comprehensive Nutritional Guide for a Healthier Life, Featuring a Two-Week Meal Plan, 85 Immunity-Boosting Recipes, and the Latest in ... and Nutritional Research (Eat for Life))