In Vitro Quotes

Just because we haven’t met Mr. Right doesn’t mean we’re doing anything wrong. And by the way, you’re brilliant and awesome, too. If I were a lesbian, I’d totally settle down with you and make lots of in vitro babies.

The evolution of human mentality has put us all in vitro now, behind the glass wall of our own ingenuity.

When it’s not enough to veto your children’s tendencies, you must in vitro them.

I’ve tried to imagine how she’d feel knowing that her cells went up in the first space missions to see what would happen to human cells in zero gravity, or that they helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization. I’m pretty sure that she—like most of us—would be shocked to hear that there are trillions more of her cells growing in laboratories now than there ever were in her body.

Accepting the fact that she did indeed have Alzheimer's, that she could only bank on two unacceptably effective drugs available to treat it, and that she couldn't trade any of this in for some other, curable disease, what did she want? Assuming the in vitro procedure worked, she wanted to live to hold Anna's baby and know it was her grandchild. She wanted to see Lydia act in something she was proud of. She wanted to see Tom fall in love. She wanted one more sabbatical year with John. She wanted to read every book she could before she could no longer read. She laughed a little, surprised at what she'd just revealed about herself. Nowhere in that list was anything about linguistics, teaching, or Harvard. She ate her last bite of cone. She wanted more sunny, seventy-degree days and ice-cream cones.

The old adage that people only want what they can’t have or what they can’t tame— is totally primitive. A being of higher origins will know instinctively that life on earth is a series of chances, moments and concepts. That’s really all that you have. So when you find one of these things and it makes you burn, or it makes you feel peace inside, or it makes you look forwards and backwards and here all at the same time— that’s when you know to hold onto it. And you hold onto it with every fiber of your being. Because it’s in the holding on of these chances and moments and concepts that life is lived. Every other kind of living is only in vitro. I don’t care what psychologists say today about how the human mind works. Because one day they will reach this pinnacle and they will see what I see and they will look upon the old ways as primitive. As long and gone. We do not wish to have what we can’t have. We wish to burn in whatever flame we have stepped into.

She was a blank, a wordless being. She was a hole in the universe.

If people could fall apart, why couldn't they fall back together?

There's just one rule, just one basic law that everyone lives under : take control or be controlled.

There is no brightness without darkness. There is no body without its shadow.

It seemed to her that living without control of your own will was hardly a step above not living at all.

I can remove and raise every unwanted fetus in vitro, then place it with the perfect loving family—thereby ending the argument between right of choice and sanctity of life.

We would need to create at least a few embryos in vitro and implant the healthiest. The others would die. Even in having children in this new life, death played its part.

Well, that's the thing, isn't it? Everyone always blames the monster--but no one ever blames the one who created it. Isn't that right?" He sneered at Moira's limp form. "Tell me, who is the monster? The creation or the creator? It has to start somewhere.

I’m one of twenty-three orphan prodigies. We were created using genetic engineering technologies that have been suppressed from the mainstream. I’m at least half a century ahead of our times in terms of official science. The embryologists who created me selected the strongest genes from about a thousand sperm donors then used in-vitro fertilization to impregnate my mother and other women.

I’m so sick of that argument. I’ve been hearing it for centuries. Playing God. Wolfgang, we played God when people believed they could dictate their baby’s gender by having sex in a certain position. We played God when we invented birth control, amniocentesis, cesarean sections, when we developed modern medicine and surgery. Flight is playing God. Fighting cancer is playing God. Contact lenses and glasses are playing God. Anything we do to modify our lives in a way that we were not born into is playing God. In vitro fertilization. Hormone replacement therapy. Gender reassignment surgery. Antibiotics.

Le emozioni. Non sapevo cosa fossero finché non le ho provate per la prima volta in questi ultimi giorni. Prima ero sempre felice, ma era una felicità artificiale. Mi piaceva la mia vita, il fatto di essere stata riprodotta in vitro o che ci fossero diverse versioni di me in giro non mi ha mai particolarmente interessato.

Everytime he looked at her she felt brighter inside, and she yearned to keep his attention, to hold his gaze.

The answer cannot be found. That should be my new life motto.

Because when you love someone, that's what you do - you get involved.

A veces escribir simplemente se trata de observar a una cosa convertirse en otra y confirmar que todo está unido a los demás con hilos invisibles.

Además, en la actualidad van apareciendo en la literatura científica estudios que demuestran que distintas sustan cias presentes en diversos alimentos son capaces de afectar a nuestra epigenética. Es el caso, por ejemplo, de una molécula presente en el brócoli, el sulforafano, capaz de regular la maquinaria epigenética en el sistema inmune y además de inhibir el crecimiento anormal de las células tumorales de próstata in vitro, regulando la metilación del gen ciclina D2.

Other countries must be laughing their heads off at us. Our “family reunification” policies mean that being related to a recent immigrant from Pakistan trumps being a surgeon from Denmark. That’s how we got gems like the “Octomom,” the unemployed single mother on welfare who had fourteen children in the United States via in vitro fertilization; Dzhokhar and Tamerlan Tsarnaev, who bombed the Boston Marathon, killing three and injuring hundreds, a few years after slitting the throats of three American Jews; and all those “homegrown” terrorists flying from Minnesota to fight with ISIS. Family reunification isn’t about admitting the spouses and minor children of immigrants we’re dying to get. We’re bringing in grandparents, second cousins, and brothers-in-law of Afghan pushcart operators—who then bring in their grandparents, second cousins, and brothers-in-law until we have entire tribes of people, illiterate in their own language, never mind ours, collecting welfare in America. We wouldn’t want our immigrants to be illiterate, unskilled, and lonesome.

I don't trust you," she whispered, her gaze caught in his as if hypnotized. He was close enough to kiss. He could dominate a room and make her head spin, and his sudden vulnerability confused her. I barely know this boy. She had to remind herself of that when he ran his fingers down her arms, leaving goose bumps in his wake.

I have not attempted to cover all aspects of the ethics of in vitro fertilization and embryo experimentation. To do that, it would be necessary to investigate several other issues, including the appropriateness of allocating scarce medical resources to this area at a time when the world has a serious problem of overpopulation. Further uses of IVF, such as donating or selling embryos to others, employing a surrogate to bear the child, using IVF to enable older women to have children (in 2008, a 70-year-old Indian woman used the technique to become the oldest woman reliably recorded as having had a child), or selecting from among a number of embryos for the one that meets some criteria of genetic desirability, raise separate ethical issues.

I can't bear to look at the screen itself, the women in pastels, like so many Jordan almonds. The men in suits, wearing equally angelic expressions. Members just like men, ostensibly. Who have vowed to be obedient to God's laws, and to repent of their sins. They've promised to be honest, true, chaste, benevolent, and virtuous; they've promised to be hopeful, and to endure all things, to seek after what is lovely, of good report, or praiseworthy. Only then will God provide a lasting solution to their loneliness and frustration. I imagine they comfort themselves, like I do, with the game of "wouldn't it be worse." Wouldn't it be worse to have a sick child, ailing parents, or a flesh-eating virus? Wouldn't it be lonelier to be trapped in a dying marriage, scarier to have crippling financial problems or to spend one's retirement fund on failed in vitro treatments? Wouldn't it be worse to live a life absent of faith, absent of purpose, absent of the love of God? I imagine they tell themselves, like I do, that a soul-crushing loneliness is a small price to pay, given the big picture. Everyone suffers. Loneliness is the human condition. And after the tests of our faith, we will triumph.

Neurons can be created in vitro by modifying the epigenesis of cnidarian cells, which suggests that the repeated evolution of functional neurons from non-neuronal cell lines cannot be too difficult to achieve. The evolvability of functional neurons is further supported by convergence on action potentials and information-transfer mechanisms in lineages for whom rapid sensory-motor mechanisms are either inaccessible or not required. For instance, action potentials have evolved in the first major origin of complex multicellularity: the green plants, some of whom, such as the carnivorous Venus flytrap, are capable of limited rapid movements. Such 'real-time' plant behaviors are made possible by action potentials that are analogous in certain ways to animal nervous systems. Mechanosensory stimulus triggers sensory hairs, which then generate a propagating action potential that initiates a rapid motor response - such as the snapping shut of two leaf lobes, resulting in the imprisonment of hapless insect prey. Though the precise biochemical mechanisms of this snapping mechanism are poorly understood, it is likely achieved by gated ion channels, which produce a flow of water or acid molecules that cause cells in the lobes to change shape, causing the lobes, which are held under tension, to snap shut. A basic memory system is also employed: to avoid snapping shut due to noise (such as raindrops), the snapping mechanism is only initiated when two stimuli separated in time by a few seconds are detected.

Jack coughed slightly and offered his hand. “Hi, uh. I’m Jack.” Kim took it. “Jack what?” “Huh?” “Your last name, silly.” “Jackson.” She blinked at him. “Your name is Jack Jackson?” He blushed. “No, uh, my first name’s Rhett, but I hate it, so…” He gestured to the chair and she sat. Her dress rode up several inches, exposing pleasing long lines of creamy skin. “Well, Jack, what’s your field of study?” “Biological Engineering, Genetics, and Microbiology. Post-doc. I’m working on a research project at the institute.” “Really? Oh, uh, my apple martini’s getting a little low.” “I’ve got that, one second.” He scurried to the bar and bought her a fresh one. She sipped and managed to make it look not only seductive but graceful as well. “What do you want to do after you’re done with the project?” Kim continued. “Depends on what I find.” She sent him a simmering smile. “What are you looking for?” Immediately, Jack’s eyes lit up and his posture straightened. “I started the project with the intention of learning how to increase the reproduction of certain endangered species. I had interest in the idea of cloning, but it proved too difficult based on the research I compiled, so I went into animal genetics and cellular biology. It turns out the animals with the best potential to combine genes were reptiles because their ability to lay eggs was a smoother transition into combining the cells to create a new species, or one with a similar ancestry that could hopefully lead to rebuilding extinct animals via surrogate birth or in-vitro fertilization. We’re on the edge of breaking that code, and if we do, it would mean that we could engineer all kinds of life and reverse what damage we’ve done to the planet’s ecosystem.” Kim stared. “Right. Would you excuse me for a second?” She wiggled off back to her pack of friends by the bar. Judging by the sniggering and the disgusted glances he was getting, she wasn’t coming back. Jack sighed and finished off his beer, massaging his forehead. “Yes, brilliant move. You blinded her with science. Genius, Jack.” He ordered a second one and finished it before he felt smallish hands on his shoulders and a pair of soft lips on his cheek. He turned to find Kamala had returned, her smile unnaturally bright in the black lights glowing over the room. “So…how did it go with Kim?” He shot her a flat look. “You notice the chair is empty.” Kamala groaned. “You talked about the research project, didn’t you?” “No!” She glared at him. “…maybe…” “You’re so useless, Jack.” She paused and then tousled his hair a bit. “Cheer up. The night’s still young. I’m not giving up on you.” He smiled in spite of himself. “Yet.” Her brown eyes flashed. “Never.

Cultured meat (or in-vitro meat, as some prefer) is meat grown from stem cells. The process was pioneered by NASA in the late 1990s, as the agency suspected this might be a good way to feed astronauts on long space flights.

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The properties of the renewal tissues enabled the original definition of stem cell behaviour in terms of the ability to self-renew and to generate differentiated progeny. But the most famous stem cell of them all is now the embryonic stem cell (ES cell). In one sense, the ES cell is the iconic stem cell. It is the type of stem cell that has attracted all of the ethical controversy, and it is what lay people are thinking of when they refer to ‘stem cell research’. But ironically, the embryonic stem cell does not exist in nature. It is a creature that has been created by mankind and exists only in the world of tissue culture: the growth of cells in flasks in the laboratory, kept in temperature-controlled incubators, exposed to controlled concentrations of oxygen and carbon dioxide, and nourished by complex artificial media. Cells grown in culture are often referred to by the Latin phrase in vitro (in glass, since the relevant containers used to be made of glass) and distinguished from in vivo (inside the living body).

If Malcolm wasn’t bitten, then he’d had the dormant version and reanimated after he died of other causes. He wasn’t on the Register, which ruled out in vitro transmission. That left only one way he could have become infected—via STD.

A plant bred in a laboratory is no more or less "real" than a baby born through in vitro fertilization. The traits matter, not the process.

Some people never changed, could always be depended on to be exactly the way they should.

Her mind drew him in, hid his image at its center, folded over him, the world slid into place, the chaos ceased.

A kind of childlike purity to her repose that made the thought of kissing her seem vile.

It's a limitless new world, and we are only just beginning to explore it.

Is in vitro fertilization where you have all the fun in a glass house?

You always know what to do,” she said. “Not always,” he said, holding her close. “Right now, for example. I’m not sure what to do.” “Why?” she asked, her eyes still closed, her face buried in his chest. “When are you going to tell me?” She lifted her head. “Tell you?” “About the baby.” “But Jack, you know the baby and mother are—” “The baby inside of you,” he said, placing a large hand over her flat tummy. A startled look crossed her features. She pushed him away a little bit. “Did someone say something to you?” she asked. “No one had to say anything. Please tell me I’m not the last to know.” “I just saw John yesterday—and how in the world would you know?” “Mel,” he said, running the back of one knuckle along her cheek, “your body’s changing. You haven’t had a period. For a while, I thought maybe you’d had a hysterectomy or something because I haven’t noticed a period since the first time we made love, but there’s a blue box under the bathroom sink. You don’t drink your beer, and you get nauseous from time to time. Not to mention being more tired than usual.” “Lord,” she said. “You never think a man will notice. Not things like that.” “Well?” She sighed. “I went to see John yesterday to confirm what I already suspected. I’m pregnant. Three months.” “You’re a midwife. How could you not know at three weeks?” “Because I assumed I was sterile. Infertile. Mark and I did everything to try to get a baby—even in vitro fertilization. To no avail. This was the last thing I ever expected.” “Ah,” he said, finally clear on why she might keep it from him. “So, here we are,” he said. “I’m sorry, Jack. You must think I’m an idiot.” He kissed her. “Of course not. Mel, I’m in love with you.” She was frozen for a second. “Oh, God,” she finally said, plummeted into tears. “Oh, God, Jack!” She buried her face in his chest and wept. “Hey, no reason to cry, baby. You a little surprised? No more than me,” he laughed. “I never thought this could happen to me. It hit me so hard, I damn near fell down. But I love you.” She continued to softly cry. “It’s okay, honey. It’ll be okay.” He stroked her hair. “You want to have a baby, obviously.” She lifted her head. “I wanted a baby so badly, I ached. But do you?” she asked. “I mean, you’re forty.” “I want everything with you. Everything. Besides, I like babies. And I’m wild about pregnant women.” “When did you decide you knew for sure?” she asked him. “At least a month ago.” He put a hand over her breast. “Sore? Haven’t you noticed the changes? Your nipples have darkened.” “I was in denial,” she said, wiping at her tears.

IVF training courses IIRRH: With more and more couples looking out for infertility treatment, the need for skilled fertility specialists has taken a huge leap in the recent years. Our IVF training courses at IIRRH are carefully structured to cater the needs of a beginner as well as a busy practitioner in the field of embryology, gynaecology and infertility management. IIRRH offers courses that provide an avenue for both scientists and clinicians to enter the field of reproductive medicine; and for those already familiar with this area, an opportunity to gain greater skillset relevant to the manipulation of fertility and the treatment of reproductive abnormalities. Designed to broaden knowledge of the underlying scientific principles and to enhance appreciation of the clinical management of infertility, the institute aims to encourage independent thought and a research orientated approach to the practice of assisted conception. Designed to broaden knowledge in the field of reproductive medicine and ART, our specialized courses include IVF training programs that cater the needs of a beginner as well as a busy practitioner in the field of embryology, gynaecology and infertility management. Our special Advanced ART course for Clinicians is apt to provide an introductory-level understanding of the clinical IVF (in-vitro fertilisation) laboratory and setting up and IVF lab. As well as the basics of the IVF lab, it also covers: • The individual protocols and procedures within the lab • The requirements that must be considered when working within it • Information ranging from embryo selection to new technologies in IVF It will allow better practice and understanding in dealing with patients and IVF cases. With the increasing demand for answers about our fertility, this course will help you understand: • The role of the clinical embryologist • Procedures conducted within the IVF laboratory For more information visit our website iirrh.org

Earlier this month, the Vatican’s top bioethics official condemned as “reprehensible” the assisted suicide of an East Bay woman, Brittany Maynard, who was suffering terminal brain cancer and said she wanted to die with dignity. Francis didn’t refer to the Maynard case specifically. While denouncing euthanasia in general, he also condemned abortion, in vitro fertilization and embryonic stem cell research.

nie możemy wszak przystać na chów niekatolicki. In vitro to jest Szatan, Niemcy i Sowieci!

We read in the paper about a fifty-five-year-old woman-you read right, that's fifty five- who had quadruplets! Since the pregnancy was in vitro, it was clearly on purpose. I've got to tell you, we were all pretty happy that we hadn't done this and also none of us had ever considered it. Nor had we considered pulling out all our teeth with pliers or slamming our fingers in the car door repeatedly just to see what it feels like.

Cette compulsion à produire semble bien avoir amené le reste de la vie sur Terre au bord de l'anéantissement. Selon O'Brien, la conscience aliénante des hommes a inventé des 'principes de continuité' compensatoires tels que Dieu, l'Etat, l'Histoire et aujourd'hui les Sciences et la Technologie pour tenter de surmonter sa fracture empirique vis à vis du processus vital et du 'temps naturel'. La gynécologie moderne, la fécondation in vitro, la maternité de substitution et les recherches en biotechnologies imitent les capacités génératrices des femmes pour pouvoir porter le pouvoir des hommes au plus haut. Les corps des habitantes des pays en voie de développement sont envahis et exploités pour étendre les frontières eurocentrées.

She was just quietly teaching history when it happened. Woke up one morning to a president-elect she hadn’t voted for. This man thought women who miscarried should pay for funerals for the fetal tissue and thought a lab technician who accidentally dropped an embryo during in vitro transfer was quirky of manslaughter.

Parece que la mayoría de maestros insisten en que la constancia y persistencia es la clave para avanzar en nuestro camino interior.

Fenugreek appears to significantly improve muscle strength and weight-lifting power output, allowing men in training, for example, to leg press an extra eighty pounds compared to those ingesting a placebo.37 Fenugreek may also possess “potent anticancer properties” in vitro.38 I don’t like the taste of the powder, so I just throw in fenugreek seeds with my broccoli seeds when I’m sprouting.

Other petri-dish studies with oregano suggest anticancer and anti-inflammatory properties. In a comparison of the effects of various spice extracts—bay leaves, fennel, lavender, oregano, paprika, parsley, rosemary, and thyme—oregano beat out all but bay leaves in its ability to suppress cervical cancer cell growth in vitro while leaving normal cells alone.77 Of 115 different foods tested for anti-inflammatory properties in vitro, oregano made it into the top five, along with oyster mushrooms, onions, cinnamon, and tea leaves.78

Despite the restriction of stem cells to just two regions of the mammalian central nervous system (CNS)—the lateral ventricle linings and the dentate gyrus—it is possible to grow neural stem cells in tissue culture from a much wider range of brain regions than this. The stem cells grow in a form called neurospheres. These are clumps of cells, up to 0.3 mm wide, that grow in suspension culture in a medium containing two specific growth factors (EGF and FGF). The cultures can be initiated from any part of the foetal CNS and often from parts of the adult CNS as well, even regions not thought to undergo continuous renewal. Neurospheres are thought each to contain a few neural stem cells, which are capable of self-renewal, plus a certain number of transit amplifying cells, that have finite division potential. When neurospheres are plated on an adhesive surface in the presence of serum, they will differentiate and form the three cell types normally generated by neuronal stem cells, which are neurons, and two types of glial cells: astrocytes and oligodendrocytes. If neurospheres are dissociated into single cells, a few per cent of these cells can establish new neurospheres, with similar properties to the original. Repeated cycles of dissociation and growth can provide substantial expansion capacity. The phenomenon of neurospheres is an example of the fact that cells may behave in a different manner in tissue culture from in vivo. Neurospheres have created enormous interest because, unlike haematopoietic stem cells, they are expandable in vitro, and because there is a hope that they might be used for cell therapy of the very intractable neurodegenerative diseases involving widespread neuronal death.

Many scientists and researchers themselves now advocate these methods, most prominently the Physicians Committee for Responsible Medicine. There is no longer any rational basis, they tell us, for the Draize test, dripping chemicals and personal-care products into the eyes of immobilized rabbits. We can now test for eye irritancy by use of human tissue systems mimicking characteristics of the eye. We can stop pouring commercial and industrial chemicals into animals. Acute toxicity is determined more accurately by in vitro methods using human cell cultures obtained from cadavers. Damage to DNA can be studied in bacteria, as in the Ames assay developed thirty years ago, adopted slowly by the EPA and yet now internationally accepted. Further experiments on animals for diseases of the heart, nicotine addiction, obesity, and many other disorders are unwarranted because we have already identified their primary causes by studying human populations.

We will continue to concentrate our energies entirely on prescription medicines and in vitro diagnostics, rather than diversify into other sectors like generics and biosimilars, over-the-counter medicines and medical devices.” ■ “With our in-house combination of pharmaceuticals and diagnostics, we are uniquely positioned to deliver personalized healthcare.” ■ “Our distinctiveness rests on four key elements: an exceptionally broad and deep understanding of molecular biology, the seamless integration of our pharmaceuticals and diagnostics capabilities, a diversity of approaches to maximise innovation, and a long-term orientation.” ■ “Our structure is built for innovation. Our autonomous research and development centres and alliances with over 200 external partners foster diversity and agility. Our global geographical scale and reach enables us to bring our diagnostics and medicines quickly to people who need them.

The government want to criminalize all abortion and disallow in vitro fertilization because it produced wasted seed...My two companions were outraged at the misogyny, incensed by their government's unjust treatment of women. It sounds like the Poland I write about of the 1930s and 40s was more feminist than now. In some ways, it was.

The healthiest nut, however, is probably walnuts. Not only do they have some of the highest antioxidant6777 and omega-36778 levels, but walnuts are the only nuts known to significantly improve artery function,6779 and they beat out others in suppressing cancer cell growth in vitro.6780

10 Common Reasons for IVF Failure  In-vitro fertilization or IVF provides a means towards parenthood to couples struggling with natural pregnancy. Although IVF is a successful, safe, and effective technique some couples may struggle with multiple IVF failures. According to Dr Vandana Narula, MBBS, MD (Obstetrics & Gynaecology), a lot of factors contribute to the success or failure of IVF. The best infertility specialist in sector 43 Chandigarh advises you to not lose hope and discuss the opportunities with your doctor. 10 Common Reasons for IVF Failure The infertility & IVF specialist in Mohali gives the following common reasons for IVF failure: 1. Poor Sperm Quality The quality of sperm determines the quality of the embryo. Men with certain medical conditions including azoospermia or diabetes may procedure poor quality and quantity of sperm. This can either hamper the development of the embryo or lead to an abnormal embryo. 2. Low Anti-Mullerian Hormone (AMH) Values AMH is a hormone secreted by cells in the egg. A good level of AMH in the woman’s blood indicates good ovarian reserve. Women with low AMH values may procedure unhealthy eggs that may not be implanted. 3. Implantation Failure Implantation failure is one of the common causes of IVF failures. It is usually caused by: A non-receptive uterus lining, thin lining, or lining affected by genital tuberculosis. Prevailing immunological conditions make the uterine environment hostile for the embryos. The endometrium has an inbuilt mechanism to reject poor-quality embryos. 4. Poor Quality of Eggs and Embryos The quality of eggs plays a significant role in IVF failure. The quality of eggs is directly related to the age of a woman and her health. The human egg consists of 23 chromosomes. If any of these chromosomes are missing or arranged incorrectly, they can produce abnormal embryos. A woman’s age also plays a key role in the egg quality. With advancing age, the eggs become less healthy and are prone to genetic abnormalities. This can make it difficult for them to be fertilized by sperm and lead to abnormal embryos.

In 2021 the company inserted three thousand filament-like electrodes, thinner than a human hair, that monitor neuron activity, into a pig’s brain. Soon they hope to begin human trials of their N1 brain implant, while another company, Synchron, has already started human trials in Australia. Scientists at a start-up called Cortical Labs have even grown a kind of brain in a vat (a bunch of neurons grown in vitro) and taught it to play Pong. It likely won’t be too long before neural “laces” made from carbon nanotubes plug us directly into the digital world.

La primera regla de la fertilización in vitro es que no se habla de la fertilización in vitro. Si entre la avalancha de libros, blogs y películas es difícil encontrar las voces de las mujeres que decidieron no ser madres, hallar las de quienes quisieron serlo pero no pudieron es prácticamente imposible.

Let us begin with a fact that is both strikingly self-evident to a cell therapist and startling to someone outside the field: in vitro fertilization (IVF) is cell therapy.

Someone had to come in a vagina before they could come out of one. Unless it's in vitro.

To successfully launch a product, generic drug companies must tread in reverse through this obstacle course. Once a generic company zeroes in on a molecule, and its scientists figure out how it operates in the body, its lawyers get to work to establish how well protected it is legally. The next step takes place in the laboratory: developing the active pharmaceutical ingredient by synthesizing it into ingredient form. That alone can take several years of trial and error. Once successful, the finished generic has to take the same form as the brand, whether that be pill, capsule, tablet, or injection. Formulating it requires additional ingredients known as excipients, which can be different, but might also be litigated. Then comes testing. In the lab, the in-vitro tests replicate conditions in the body. During dissolution tests, for example, the drug will be put in beakers whose contents mimic stomach conditions, to see how the drugs break down. But some of the most important tests are in-vivo—when the drug is tested on people. Brand-name companies must test new drugs on thousands of patients to prove that they are safe and effective. Generic companies have to prove only that their drug performs similarly in the body to the brand-name drug. To do this, they must test it on a few dozen healthy volunteers and map the concentration of the drug in their blood. The results yield a graph that contains the all-important bioequivalence curve. The horizontal line reflects the time to maximum concentration (Tmax) of drug in the blood. The vertical line reflects the peak concentration (Cmax) of drug in the blood. Between these two axes lies the area under the curve (AUC). The test results must fall in that area to be deemed bioequivalent. Every batch of drugs has variation. Even brand-name drugs made in the same laboratory under the exact same conditions will have some batch-to-batch differences. So, in 1992, the FDA created a complex statistical formula that defined bioequivalence as a range—a generic drug’s concentration in the blood could not fall below 80 percent or rise above 125 percent of the brand name’s concentration. But the formula also required companies to impose a 90 percent confidence interval on their testing, to ensure that less than 20 percent of samples would fall outside the designated range and far more would land within a closer range to the innovator product.

These potential advantages of DNA computing over the traditional approach and the seminal experimental work of Adleman, demonstrating the practical in vitro implementation of a DNA algorithm for solving an instance of the Hamiltonian path problem, caused a strong increase of interest in DNA computing over the past years. Although the set of “bio-operations” that can be executed on DNA strands in a laboratory (including operators such as synthesizing, mixing, annealing, melting, amplifying, separating, extracting, cutting, and ligating DNA strands) seems fundamentally different from traditional programming languages, theoretical work on the computational power of various models of DNA computing demonstrates that certain subsets of these operators are computationally complete. In other words, everything that is Turing-computable can also be computed by these DNA models of computation. Furthermore, it has also been shown that universal systems exist, so that the programmable DNA computer is theoretically possible. The algorithms for DNA computing that have been presented in the literature use an approach that will not work for NP-complete problems of realistic size, because these algorithms are all based on extracting an existing solution from a sufficiently large initial population of solutions. Although a huge number (≈ 1012) of DNA molecules (i.e., potential solutions to a given problem) can be manipulated in parallel, this so-called filtering approach (i.e., generate and test) quickly becomes infeasible as problem sizes grow (e.g., a 500-node instance of the traveling salesman problem has > 101000 potential solutions).

CAR-T therapy in a very small subset of cancer patients with lymphoid disease is fantastically successful, albeit causing severe short-term toxicities and many known and unknown lifelong side effects. It is clear that much work lies ahead before this strategy can be scaled up for general use. Yet the hype surrounding CAR-T is such that practically every patient questions me about why they are being deprived of the magic cure. The results are not always magical: Despite high-target, cell-specific killing in vitro and encouraging preclinical efficacies in murine tumor models, clinical responses of adoptively transferred T cells expressing α-folate receptor (FR) specific CAR in ovarian cancer were disappointing. No reduction of tumor burden was seen in the 14 patients studied. The absence of efficacy was ascribed to lack of specific trafficking of the T cells to tumor and short persistence of the transferred T cells.

Maybe Sloan would agree to a deal. I’d talk to someone about some of my issues if she would agree to go to grief counseling. It wasn’t me giving in to Josh like she wanted, but Sloan knew how much I hated therapists, and she’d always wanted me to see someone. I was debating how to pitch this to her when I glanced into the living room and saw it—a single purple carnation on my coffee table. I looked around the kitchen like I might suddenly find someone in my house. But Stuntman was calm, plopped under my chair. I went in to investigate and saw that the flower sat on top of a binder with the words “just say okay” written on the outside in Josh’s writing. He’d been here? My heart began to pound. I looked again around the living room like I might see him, but it was just the binder. I sat on the sofa, my hands on my knees, staring at the binder for what felt like ages before I drew the courage to pull the book into my lap. I tucked my hair behind my ear and licked my lips, took a breath, and opened it up. The front page read “SoCal Fertility Specialists.” My breath stilled in my lungs. What? He’d had a consultation with Dr. Mason Montgomery from SoCal Fertility. A certified subspecialist in reproductive endocrinology and infertility with the American Board of Obstetrics and Gynecology. He’d talked to them about in vitro and surrogacy, and he’d had fertility testing done. I put a shaky hand to my mouth, and tears began to blur my eyes. I pored over his test results. Josh was a breeding machine. Strong swimmers and an impressive sperm count. He’d circled this and put a winking smiley face next to it and I snorted. He’d outlined the clinic’s high success rates—higher than the national average—and he had gotten signed personal testimonials from previous patients, women like me who used a surrogate. Letter after letter of encouragement, addressed to me. The next page was a complete breakdown on the cost of in vitro and information on Josh’s health insurance and what it covered. His insurance was good. It covered the first round of IVF at 100 percent. He even had a small business plan. He proposed selling doghouses that he would build. The extra income would raise enough money for the second round of in vitro in about three months. The next section was filled with printouts from the Department of International Adoptions. Notes scrawled in Josh’s handwriting said Brazil just opened up. He broke down the process, timeline, and costs right down to travel expenses and court fees. I flipped past a sleeve full of brochures to a page on getting licensed for foster care. He’d already gone through the background check, and he enclosed a form for me, along with a series of available dates for foster care orientation classes and in-home inspections. Was this what he’d been doing? This must have taken him weeks. My chin quivered. Somehow, seeing it all down on paper, knowing we’d be in it together, it didn’t feel so hopeless. It felt like something that we could do. Something that might actually work. Something possible. The last page had an envelope taped to it. I pried it open with trembling hands, my throat getting tight. I know what the journey will look like, Kristen. I’m ready to take this on. I love you and I can’t wait to tell you the best part…Just say okay. I dropped the letter and put my face into my hands and sobbed like I’d never sobbed in my life. He’d done all this for me. Josh looked infertility dead in the eye, and his choice was still me. He never gave up. All this time, no matter how hard I rejected him or how difficult I made it, he never walked away from me. He just changed strategies. And I knew if this one didn’t work he’d try another. And another. And another. He’d never stop trying until I gave in. And Sloan—she knew. She knew this was here, waiting for me. That’s why she’d made me leave. They’d conspired to do this.

Siéntete y obsérvate a ti misma, pregúntate cómo te encuentras a nivel interno y externo. Siente la calma de esa parada. Sé consciente varias veces de que estás viva y respiras, y que puedes estar mirando y oyendo lo que te rodea.

She whirled on me. “No.” Her face was hard. “I listened to you talk about having kids for months. We’ve already had the conversation. Plenty of times. And there is absolutely nothing you can say to me now to convince me that’s suddenly not some major priority for you. I can’t give you a family. I’m no different from Celeste.” “Celeste didn’t want kids. It’s not the same thing,” I said. She scoffed, waving around her toothbrush. “Isn’t it? The outcome is the same. In vitro is only forty percent successful—did you know that? Do you even know what it costs? Or how hard it is to find a surrogate? We could try for years, go broke, and never even have one baby. Not even one.

Fuck, I never got enough of my wife. She was the sexiest woman alive. I loved every inch of her. I loved her stretch marks and her scars, the specks in her eyes and the birthmark on her neck. All her flawless imperfections. I was grateful every moment of every single day that Brandon brought me to her. She was my everlasting gift from a man I’d never forget for the rest of my life. I broke away and put my forehead to hers. “So you want In-N-Out for lunch and steaks for dinner, right?” She nodded and put her hand over my heart where the tattoo of her name was. “Josh? I think I could be ready again to keep trying. Should we start talking about surrogacy? Carmen is still down for it, right?” I knew why she was asking. She still wanted to give me my baseball team. But my dreams had changed. Seeing the strain of the in vitro process and how much it took out of her emotionally and physically—I just wanted her to be happy. I wanted her to enjoy our son. She never complained, but I knew she was tired of the doctor’s visits and the hormone injections and the disappointment. If she was up for it in a few years, maybe we’d try again or look into the other options. We were young—we had time. But I didn’t want her to do it for me because she thought she owed it to me. She’d done enough. I put my hands on her face. “Let’s take a break, Kristen. I’m happy where we are. And if this is our family, I’m good with that.” The relief was visible in her eyes. “Are you sure?” My mouth curved up into a smile. “I’m very sure. I have everything I need.

human liver cells in in vitro studies.65 A single confirmatory clinical (human) trial has been published in which a purple sweet potato concoction successfully dampened liver inflammation better than a placebo.66 When it came to suppressing the growth of human liver cancer cells in a petri dish,67 cranberries beat out the other most common fruits in the United States: apples, bananas, grapefruits, grapes, lemons, oranges, peaches, pears, pineapples, and strawberries. Other studies have found that cranberries are also effective in vitro

eyeing my face in that same accusatory way I’ve seen my entire life. As if I had begged in vitro for a birthmark, this personal affront to his sanitized, temperature-controlled world.

appear to help turn BRCA protection back on, removing the methyl straitjacket the tumor tried to place on it.144 The dose breast cancer researchers used to achieve this result in vitro was pretty hefty, though—the equivalent to eating about a cup of soybeans. Soy may also help women with variations of other breast cancer susceptibility genes known as MDM2 and CYP1B1.

Knowledge of the specific genetic variants that caused NGLY1 disease in Bertrand and Grace could be used to increase the chances of conceiving a healthy future sibling, thanks to a technique that has been around now for more than twenty years: in vitro fertilization.

Caperton Fertility Institute is the leading fertility practice in the Southwest, combining personalized, compassionate care with deep clinical expertise and the region’s most advanced medical technology to help thousands of people achieve their dream of parenthood. CFI’s clinics, located in Albuquerque, NM, and El Paso, TX, are nationally acclaimed and well-known for unprecedented pregnancy success rates. Our team provides fertility-related services and treatment options such as in-vitro fertilization (IVF), artificial insemination, fertility surgery and more.

Las palabras están vivas y, contrario a lo que podría creerse, no son solamente reflejo de la manera en que pensamos, también son motor de ideas y acciones.

Lo que elijo no decir también está escrito.

El origen del lenguaje -y el psicoanálisis es la cura por la palabra- no está en la lógica, sino en la imaginación.

BONUS BENEFITS OF TURMERIC: Powerful antibacterial, antifungal, and antiviral (even helps inhibit the reproduction of the HIV virus); antiaging (reduces oxidative stress and down-regulates age-related genes); reduces chronic pain; antioxidant; anti-inflammatory; effective in preventing liver and kidney toxicity; potential treatment for skin disorders (rosacea and psoriasis), HIV, septic shock, cardiovascular disease, lung fibrosis, arthritis, and inflammatory bowel disease; anti-atherosclerotic. And that’s just what we’ve discovered so far! In-vitro and animal studies suggest that turmeric may offer anticancer benefits as well.

In-Vitro Fertilisation (IVF) is a medical procedure that aids individuals or couples in achieving pregnancy. The process involves fertilising an egg with sperm outside the body in a laboratory. The resulting embryo is then implanted into the uterus. IVF is widely used to address infertility and other reproductive challenges.