Human Mutation Quotes

We're so self-important. So arrogant. Everybody's going to save something now. Save the trees, save the bees, save the whales, save the snails. And the supreme arrogance? Save the planet! Are these people kidding? Save the planet? We don't even know how to take care of ourselves; we haven't learned how to care for one another. We're gonna save the fuckin' planet? . . . And, by the way, there's nothing wrong with the planet in the first place. The planet is fine. The people are fucked! Compared with the people, the planet is doin' great. It's been here over four billion years . . . The planet isn't goin' anywhere, folks. We are! We're goin' away. Pack your shit, we're goin' away. And we won't leave much of a trace. Thank God for that. Nothing left. Maybe a little Styrofoam. The planet will be here, and we'll be gone. Another failed mutation; another closed-end biological mistake.

I declare that The Beatles are mutants. Prototypes of evolutionary agents sent by God, endowed with a mysterious power to create a new human species, a young race of laughing freemen.

Somewhere in our DNA must lie the key mutation (or, more probably, mutations) that set us apart—the mutations that make us the sort of creature that could wipe out its nearest relative, then dig up its bones and reassemble its genome.

You think man can destroy the planet? What intoxicating vanity. Let me tell you about our planet. Earth is four-and-a-half-billion-years-old. There's been life on it for nearly that long, 3.8 billion years. Bacteria first; later the first multicellular life, then the first complex creatures in the sea, on the land. Then finally the great sweeping ages of animals, the amphibians, the dinosaurs, at last the mammals, each one enduring millions on millions of years, great dynasties of creatures rising, flourishing, dying away -- all this against a background of continuous and violent upheaval. Mountain ranges thrust up, eroded away, cometary impacts, volcano eruptions, oceans rising and falling, whole continents moving, an endless, constant, violent change, colliding, buckling to make mountains over millions of years. Earth has survived everything in its time. It will certainly survive us. If all the nuclear weapons in the world went off at once and all the plants, all the animals died and the earth was sizzling hot for a hundred thousand years, life would survive, somewhere: under the soil, frozen in Arctic ice. Sooner or later, when the planet was no longer inhospitable, life would spread again. The evolutionary process would begin again. It might take a few billion years for life to regain its present variety. Of course, it would be very different from what it is now, but the earth would survive our folly, only we would not. If the ozone layer gets thinner, ultraviolet radiation sears the earth, so what? Ultraviolet radiation is good for life. It's powerful energy. It promotes mutation, change. Many forms of life will thrive with more UV radiation. Many others will die out. Do you think this is the first time that's happened? Think about oxygen. Necessary for life now, but oxygen is actually a metabolic poison, a corrosive glass, like fluorine. When oxygen was first produced as a waste product by certain plant cells some three billion years ago, it created a crisis for all other life on earth. Those plants were polluting the environment, exhaling a lethal gas. Earth eventually had an atmosphere incompatible with life. Nevertheless, life on earth took care of itself. In the thinking of the human being a hundred years is a long time. A hundred years ago we didn't have cars, airplanes, computers or vaccines. It was a whole different world, but to the earth, a hundred years is nothing. A million years is nothing. This planet lives and breathes on a much vaster scale. We can't imagine its slow and powerful rhythms, and we haven't got the humility to try. We've been residents here for the blink of an eye. If we're gone tomorrow, the earth will not miss us.

There seems to be an inborn drive in all human beings not to live in a steady emotional state, which would suggest that such a state is not tolerable to most people. Why else would someone succumb to the attractions of romantic love more than once? Didn’t they learn their lesson the first time or the tenth time or the twentieth time? And it’s the same old lesson: everything in this life—I repeat, everything—is more trouble than it’s worth. And simply being alive is the basic trouble. This is something that is more recognized in Eastern societies than in the West. There’s a minor tradition in Greek philosophy that instructs us to seek a state of equanimity rather than one of ecstasy, but it never really caught on for obvious reasons. Buddhism advises its practitioners not to seek highs or lows but to follow a middle path to personal salvation from the painful cravings of the average sensual life, which is why it was pretty much reviled by the masses and mutated into forms more suited to human drives and desires. It seems evident that very few people can simply sit still. Children spin in circles until they collapse with dizziness.

However, there is a way to know for certain that Noah’s Flood and the Creation story never happened: by looking at our mitochondrial DNA (mtDNA).  Mitochondria are the “cellular power plants” found in all of our cells and they have their own DNA which is separate from that found in the nucleus of the cell.  In humans, and most other species that mitochondria are found in, the father’s mtDNA normally does not contribute to the child’s mtDNA; the child normally inherits its mtDNA exclusively from its mother.  This means that if no one’s genes have mutated, then we all have the same mtDNA as our brothers and sisters and the same mtDNA as the children of our mother’s sisters, etc. This pattern of inheritance makes it possible to rule out “population bottlenecks” in our species’ history.  A bottleneck is basically a time when the population of a species dwindled to low numbers.  For humans, this means that every person born after a bottleneck can only have the mtDNA or a mutation of the mtDNA of the women who survived the bottleneck. This doesn’t mean that mtDNA can tell us when a bottleneck happened, but it can tell us when one didn’t happen because we know that mtDNA has a rate of approximately one mutation every 3,500 years (Gibbons 1998; Soares et al 2009). So if the human race were actually less than 6,000 years old and/or “everything on earth that breathed died” (Genesis 7:22) less than 6,000 years ago, which would be the case if the story of Adam and the story of Noah’s flood were true respectively, then every person should have the exact same mtDNA except for one or two mutations.  This, however, is not the case as human mtDNA is much more diverse (Endicott et al 2009), so we can know for a fact that the story of Adam and Eve and the story of Noah are fictional.   There

They're not ‘fellas.’  They’re not anywhere near human. They’re nothing but leaking sacks of mutated maggots, just like you.” Lookswise, he and the other angels I’d seen were closer to living Adonises, complete with god-like faces and presence. But inside, they were maggots for sure.

Vampires were hardly the monsters we were made out to be in fairy tales and television shows. We were hardly different from humans, but for the genetic mutation, fangs, silvering eyes, and periodic penchant for blood. What? I said hardly different.

Our lack of community is intensely painful. A TV talk show is not community. A couple of hours in a church pew each Sabbath is not community. A multinational corporation is neither a human nor a community, and in the sweatshops, defiled agribusiness fields, genetic mutation labs, ecological dead zones, the inhumanity is showing. Without genuine spiritual community, life becomes a struggle so lonely and grim that even Hillary Clinton has admitted "it takes a village".

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal.

To love a swamp, however, is to love what is muted and marginal, what exists in the shadows, what shoulders its way out of mud and scurries along the damp edges of what is most commonly praised. And sometimes its invisibility is a blessing. Swamps and bogs are places of transition and wild growth, breeding grounds, experimental labs where organisms and ideas have the luxury of being out of the spotlight, where the imagination can mutate and mate, send tendrils into and out of the water.

The day I bought my cane, I realized I was through with the burden of feet. Instead, I am going to become a mermaid. I have always liked the ocean, the promise of depth. I am tired of this dry world, all of this dust and sickness, these barren fields. I want to dive without drowning. I want to kiss sharks. I want men to carve me into the bows of their ships like a prayer, before I lure them into the depths with my fishnet mouth. I want the beauty, the gorgeous mutation, the fairytale of half body. All the wisdom of a woman, without the failures of sex. I am plunging. I am not coming up for air. I do not want all this human, my legs move like they resent being legs, my body is wrecked by all this gravity. I cannot face another morning waking up with no hope of a fairytale. Here on land, I am always drowning. Here on land, I cannot move.

The differences you perceive between Humans—between groups of Humans—are the result of isolation and inbreeding, mutation, and adaptation to different Earth environments

Broadly speaking, the human brain is a collection of software hacks compiled into a single, somehow-functional unit. Each “feature” was added as a random mutation that solved some specific problem to increase our odds of survival. In short, the human brain is a mess.

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.

Evolution Idea Perspective Word Breaks into our code Per-mutating atoms Of our evolutionary Self-s Our sensory navigating device Accepts or rejects the impulse Creating realities of our choice A natural drift takes us from an amoeba to a human A very determined choice takes us further Allowing us To squeeze our way through To awake-n To God and his gift of Aware-ness

Your kidding" i said. "we've escaped from top- security prisons, lived on our own for years, made tons of smarty-pants grown-ups look like fools without even trying,eaten desert rats with no A1 steak sauce, and your telling me we're minors and have to have guardians?" I shook my head, staring at him. "Listen pal, i grew up in a freaking dog crate. I've seen horrible, part-human mutations die gut-wrenching deaths. I've had people, mutants, and robots trying to kill me twenty-four/seven for as long as i can remember, and you think i'm gonna cave to state law? are you bonkers?

But even if I know what governs their trajectory, if I know the rules of the movement of things and how things are organized and how certain mutations, transformations, gestations take place, even if I know all that, I shall only have learnt how to get along after a fashion in the enormous gaol, the oppressive prison in which I am held. What a farce, what a snare, what a booby-trap. We were born cheated. For if we are not to know, if there is nothing to know, why do we have this longing to know?

At this point, godless materialists might be cheering. If humans evolved strictly by mutation and natural selection, who needs God to explain us? To this, I reply: I do. The comparison of chimp and human sequences, interesting as it is, does not tell us what it means to be human. In my views, DNA sequence alone, even if accompanied by a vast trove of data on biological function, will never explain certain special human attributes, such as the knowledge of the Moral Law and the universal search for God. Freeing God from the burden of special acts of creation does not remove Him as the source of the things that make humanity special, and of the universe itself. It merely shows us something of how He operates.

Julian is bluff and sturdy, royal; he possesses a gracefully muscular, equine beauty so natural it suggests that beauty itself is a fundamental human condition and not a mutation in the general design.

This time we weren’t disturbed either by traveling through time or a cheeky gargoyle demon. While “Hallelujah” was running, the kiss was gentle and careful, but then Gideon buried both hands in my hair and held me very close. It wasn’t a gentle kiss anymore, and my reaction surprised me. I suddenly felt very soft and lightweight, and my arms went around Gideon’s neck of their own accord. I had no idea how, but at some point in the next few minutes, still kissing without a break, we landed on the green sofa, and we went on kissing there until Gideon abruptly sat up and looked at his watch. “Like I said, it really is a shame I’m not allowed to kiss you anymore,” he remarked rather breathlessly. The pupils of his eyes looked huge, and his cheeks were definitely flushed. I wondered what I looked like myself. As I’d temporarily mutated into some kind of human blancmange, there was no way I could get out of my half-lying position. And I realized, with horror, that I had no idea how much time had passed since Bon Jovi stopped singing “Hallelujah.” Ten minutes? Half an hour? Anything was possible. Gideon looked at me, and I thought I saw something like bewilderment in his eyes. “We’d better collect our things,” he said at last. “And you need to do something about your hair—it looks as if some idiot has been digging both hands into it and dragging you down on a sofa. Whoever’s back there waiting for us will put two and two together—oh, my God, don’t look at me like that.” “Like what?” “As if you couldn’t move.” “But I can’t,” I said, perfectly seriously. “I’m a blancmange. You’ve turned me into blancmange.” A brief smile brightened Gideon’s face, and then he jumped up and began stowing my school things in my bag. “Come along, little blancmange. Stand up.

We are only chance visitants to this jungle of blind mutations. The natural world existed when we did not, and it will continue to exist long after we are gone. The supernatural crept into life only when the door of consciousness was opened in our heads. The moment we stepped through that door, we walked out on nature. Say what we will about it and deny it till we die--we are blighted by our knowing what is too much to know and too secret to tell one another if we are to stride along our streets, work at our jobs, and sleep in our beds. It is the knowledge of a race of beings that is only passing through this shoddy cosmos.

There's no denying his resemblance to the Rodin bronze - the slender, effortless muscularity of youth, the extravagant nonchalance of it; that sense that beauty is in fact the natural human condition and not the rarest of mutations.

For example, you might have a sever sunburn as a child. Many decades later, you might develop skin cancer at that same site. This means it probably took that long for the other mutation to occur and finally tip the cell into a cancerous mode.

The water wasn't the same down here. Water is what runs out of the kitchen taps or a playground drinking fountain. It fills bathubs and pools and yes, of course, the ocean- but at a certain depth, water becomes a barrier from all you remember, all you think you know. You're trapped within it, a plaything of it. Focus erodes. Your thoughts mutate. The pressure. The pressure. The soul can't cope with that. It shouldn't be expected to. Humans weren't built for this. There's a reason nothing lives down here. Or nothing should.

Who wouldn’t want to fuck these people up? Which of us does not understand, in our own less presentable depths, the demons and wizards compelled to persecute human mutations clearly meant, by deities thinking only of their own entertainment, to make almost everyone feel even lonelier and homelier, more awkward, more doubtful and blamed, than we actually are?

Among the mutations that have affected the knowledge of things ... only one, which began a century and a half ago ... has allowed the figure of man to appear.

I feel that the change, the mutation in consciousness, will occur spontaneously once certain pressures now in operation are removed. I feel that the principal instrument of monopoly and control that prevents expansion of consciousness is the word lines controlling thought, feeling and apparent sensory impressions of the human host.

It's not human. It's not primal. So we don't understand it. It's a more recent mutation. The things we all have, love and hate and passion, and the need to eat and yell and screw, these are things every human has. But there's this new mutation, this ability to stand between a human being and some small measure of justice and blame it on some regulation. To say that the form was filled out incorrectly.

It has something to do with the cosmic rays coming from outer space. They strike some person or thing, and then you get a mutation - like the stripes on a zebra. The attraction of two such mutants to one another would have an almost incestuous appeal and be far stronger than the bond of love between ordinary human beings.

We must all obey the great law of change. It is the most powerful law of nature, and the means perhaps of its conservation. All we can do, and that human wisdom can do, is to provide that the change shall proceed by insensible degrees. This has all the benefits which may be in change, without any of the inconveniences of mutation.

Did you know that only a tiny minority of viruses cause illness in humans? No one knows how many viruses there are, but their real role, when you get right down to it, is to aid in mutations, to create diversity among life forms. I've read a lot of books on the subject-when you don't need much sleep you have a lot of time to read-and I can tell you that if it weren't for viruses, mankind would never have evolved on this planet. Some viruses get right inside the DNA and change your genetic code, did you know that? And no one can say for sure that HIV, for example, won't one day prove to have been rewriting our genetic code in a way that's essential to our survival as a race. I'm a man who consciously commits murders and scares the hell out of people and makes them reconsider everything, so I'm definitely malignant, yet I think I play a necessary role in this world.

What are humans meant to do; why are we here? Are we a mutation on the earth destroying its host? Are we a cancer destined to kill what supports us? I think not. So exploring this question is a powerful exercise in meaning; what is the meaning of human existence?

At least 15 percent of human females possess a genetic mutation that gives them an extra (fourth) type of color photoreceptor—and this allows them to discriminate between colors that look identical to the majority of us with a mere three types of color photoreceptors.

a mutation in that strain might have made it especially aggressive, efficient, transmissible, and fierce.

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable rights, that among these are life, liberty, and the pursuit of happiness. According to the science of biology, people were not ‘created’. They have evolved. And they certainly did not evolve to be ‘equal’. The idea of equality is inextricably intertwined with the idea of creation. The Americans got the idea of equality from Christianity, which argues that every person has a divinely created soul, and that all souls are equal before God. However, if we do not believe in the Christian myths about God, creation and souls, what does it mean that all people are ‘equal’? Evolution is based on difference, not on equality. Every person carries a somewhat different genetic code, and is exposed from birth to different environmental influences. This leads to the development of different qualities that carry with them different chances of survival. ‘Created equal’ should therefore be translated into ‘evolved differently’. Just as people were never created, neither, according to the science of biology, is there a ‘Creator’ who ‘endows’ them with anything. There is only a blind evolutionary process, devoid of any purpose, leading to the birth of individuals. ‘Endowed by their creator’ should be translated simply into ‘born’. Equally, there are no such things as rights in biology. There are only organs, abilities and characteristics. Birds fly not because they have a right to fly, but because they have wings. And it’s not true that these organs, abilities and characteristics are ‘unalienable’. Many of them undergo constant mutations, and may well be completely lost over time. The ostrich is a bird that lost its ability to fly. So ‘unalienable rights’ should be translated into ‘mutable characteristics’. And what are the characteristics that evolved in humans? ‘Life’, certainly. But ‘liberty’? There is no such thing in biology. Just like equality, rights and limited liability companies, liberty is something that people invented and that exists only in their imagination. From a biological viewpoint, it is meaningless to say that humans in democratic societies are free, whereas humans in dictatorships are unfree. And what about ‘happiness’? So far biological research has failed to come up with a clear definition of happiness or a way to measure it objectively. Most biological studies acknowledge only the existence of pleasure, which is more easily defined and measured. So ‘life, liberty, and the pursuit of happiness’ should be translated into ‘life and the pursuit of pleasure’. So here is that line from the American Declaration of Independence translated into biological terms: We hold these truths to be self-evident, that all men evolved differently, that they are born with certain mutable characteristics, and that among these are life and the pursuit of pleasure.

Hi there, cutie." Ash turned his head to find an extremely attractive college student by his side. With black curly hair, she was dressed in jeans and a tight green top that displayed her curves to perfection. "Hi." "You want to go inside for a drink? It's on me." Ash paused as he saw her past, present, and future simultaneously in his mind. Her name was Tracy Phillips. A political science major, she was going to end up at Harvard Med School and then be one of the leading researchers to help isolate a mutated genome that the human race didn't even know existed yet. The discovery of that genome would save the life of her youngest daughter and cause her daughter to go on to medical school herself. That daughter, with the help and guidance of her mother, would one day lobby for medical reforms that would change the way the medical world and governments treated health care. The two of them would shape generations of doctors and save thousands of lives by allowing people to have groundbreaking medical treatments that they wouldn't have otherwise been able to afford. And right now, all Tracy could think about was how cute his ass was in leather pants, and how much she'd like to peel them off him. In a few seconds, she'd head into the coffee shop and meet a waitress named Gina Torres. Gina's dream was to go to college herself to be a doctor and save the lives of the working poor who couldn't afford health care, but because of family problems she wasn't able to take classes this year. Still Gina would tell Tracy how she planned to go next year on a scholarship. Late tonight, after most of the college students were headed off, the two of them would be chatting about Gina's plans and dreams. And a month from now, Gina would be dead from a freak car accident that Tracy would see on the news. That one tragic event combined with the happenstance meeting tonight would lead Tracy to her destiny. In one instant, she'd realize how shallow her life had been, and she'd seek to change that and be more aware of the people around her and of their needs. Her youngest daughter would be named Gina Tory in honor of the Gina who was currently busy wiping down tables while she imagined a better life for everyone. So in effect, Gina would achieve her dream. By dying she'd save thousands of lives and she'd bring health care to those who couldn't afford it... The human race was an amazing thing. So few people ever realized just how many lives they inadvertently touched. How the right or wrong word spoken casually could empower or destroy another's life. If Ash were to accept Tracy's invitation for coffee, her destiny would be changed and she would end up working as a well-paid bank officer. She'd decide that marriage wasn't for her and go on to live her life with a partner and never have children. Everything would change. All the lives that would have been saved would be lost. And knowing the nuance of every word spoken and every gesture made was the heaviest of all the burdens Ash carried. Smiling gently, he shook his head. "Thanks for asking, but I have to head off. You have a good night." She gave him a hot once-over. "Okay, but if you change your mind, I'll be in here studying for the next few hours." Ash watched as she left him and entered the shop. She set her backpack down at a table and started unpacking her books. Sighing from exhaustion, Gina grabbed a glass of water and made her way over to her... And as he observed them through the painted glass, the two women struck up a conversation and set their destined futures into motion. His heart heavy, he glanced in the direction Cael had vanished and hated the future that awaited his friend. But it was Cael's destiny. His fate... "Imora thea mi savur," Ash whispered under his breath in Atlantean. God save me from love.

If one of the people who'd gone Cold drank human blood, the infection mutated. It killed the host and then raised them back up again, Colder than before. Cold through and through, forever and ever.

From time to time the human species spawns predators that feed on those around them. They’re not the species. They’re mutations of the species. In my opinion these freaks have no right to suck oxygen from the atmosphere. But they’re here, so I help cage them up and put them where they can’t hurt others. I make life safer for the folks who get up, go to work each day, raise their kids or their tomatoes, or their tropical fish, and watch the ball game in the evening. They are the human species.

It is a rule in paleontology that ornamentation and complication precede extinction. And our mutation, of which the assembly line, the collective farm, the mechanized army, and the mass production of food are evidences or even symptoms, might well correspond to the thickening armor of the great reptiles—a tendency that can end only in extinction. If this should happen to be true, nothing stemming from thought can interfere with it or bend it. Conscious thought seems to have little effect on the action or direction of our species.

This humanity of woman, borne its full time in suffering and humiliation, will come to light when she will have stripped off the conventions of mere femininity in the mutations of her outward status, and those men who do not yet feel it approaching today will be surprised and struck by it. Some day (and for this, particularly in the northern countries, reliable signs are already speaking and shining), some day there will be girls and women whose name will no longer signify merely an opposite of the masculine, but something in itself, something that makes one think, not of any complement and limit, but only of life and existence: the feminine human being.

To get from “protoplasmal primordial atomic globule” (as Gilbert and Sullivan put it) to sentient upright modern human has required you to mutate new traits over and over in a precisely timely manner for an exceedingly long while.

I don’t know what to . . . to think.” There was a horrifying burn of tears crawling up my throat. “This is all overwhelming for you, I imagine. The whole world as you know it is on the brink of great change, and you’re here and don’t even know my name.” The man smiled so broadly, I wondered if it hurt. “You can call me Rolland.” Then he extended a hand. My gaze dropped to it and I made no attempt to take it. Rolland chuckled as he turned and strolled back to the desk. “So, you’re a hybrid? Mutated and linked to him on such an intense level that if one of you dies, so does the other?” His question caught me off guard, but I kept quiet. He sat on the edge of the desk. “You’re actually the first hybrid I’ve seen.” “She really isn’t anything special.” The redhead sneered. “Frankly, she’s rather filthy, like an unclean animal.” As stupid as it was, my cheeks heated, because I was filthy, and Daemon had just physically removed me from him. My pride—my everything—was officially wounded. Rolland chuckled. “She’s had a rough day, Sadi.” At her name, every muscle in my body locked up, and my gaze swung back to her. That was Sadi? The one Dee said was trying to molest Daemon—my Daemon? Anger punched through the confusion and hurt. Of course it would have to be a freaking walking and talking model and not a hag. “Rough day or not, I can’t imagine she cleans up well.” Sadi looked at Daemon as she placed a hand on his chest. “I’m kind of disappointed.” “Are you?” Daemon replied.
 Every hair on my body rose as my arms unfolded.
 “Yes,” she purred. “I really think you can do better. Lots better.” As she spoke, she trailed red-painted fingers down the center of his chest, over his abdomen, heading straight for the button on his jeans. And oh, hell to the no. “Get your hands off him.”
 Sadi’s head snapped in my direction. “Excuse me?”
 “I don’t think I stuttered.” I took a step forward. “But it looks like you need me to repeat it. Get your freaking hands off him.” One side of her plump red lips curled up. “You want to make me?”
 In the back of my head, I was aware that Sadi didn’t move or speak like the other Luxen. Her mannerisms were too human, but then that thought was quickly chased away when Daemon reached down and pulled her hand away. “Stop it,” he murmured, voice dropped low in that teasing way of his. I saw red. The pictures on the wall rattled and the papers on the desk started to lift up. Static charged over my skin. I was about to pull a Beth right here, seconds away from floating to the ceiling and ripping out every strand of red— “And you stop it,” Daemon said, but the teasing quality was gone from his words. There was a warning in them that took the wind right out of my pissed-off sails. The pictures settled as I gaped at him. Being slapped in the face would’ve been better.

In art, as in biology, there is a phenomenon that can be described as mutation, in which appearances radically change at a tempo much more rapid than that at which they normally proceed. As in the case of biology, we have no means to determine the process by which this radical change occurs. Yet we do know that it is a reaction to a form of congestion. It is a desperate change due to the arrival at a point where the corollaries to a situation are exhausted, when the stimulus to additional growth is sluggish and a rapid rejuvenation is needed so that art, through disuse, does not atrophy in much the same way as an unused human organ. Here art must attain a new start if it is to survive. Then, assiduously, it renews its traditions by marriage with alien traditions, by the reexamination of its own processes, and by those means reestablishes contact again with its own roots. It is in this way that new plastic worlds are born. For art, like a race, cannot inbreed very long without losing its incentives to continue; it needs the rejuvenation of new experiences and new blood. These mutations, it must be clear, however, do not constitute a change in properties, or mean that art has discarded its past. On the contrary, mutation involves a more conscious evaluation of art’s inheritance and the redirection of that inheritance into channels where it can be continued with greater force.

Aeons change, not as the result of some war in heaven or astrological event. Rather they are simply the consequence of some improved modification in human consciousness. Obviously, such a mutation needs to be universal and fundamental: something most of us share with our fellows, something as simple as how we perceive our relationship with the Sun.

By ignoring our health and consuming unhealthy products, we are unknowingly contributing to the genetic mutation of the human species.

Two million years ago, genetic mutations resulted in the appearance of a new human species called Homo erectus.

SHERMAN - Already doth the wicked beast mutate, Into a human form. O Father, shoot! [Marty retreats into the barn] Pa - Die, alien - our planet is not thine, Thou mutant son of wenches most impure!

The human has genetic adaptation to natural electromagnetic radiation. Increasing, reducing or removing the natural radiation exposures results in a sickened human that may progress onto a diseased state.

We chose to destroy the human population because it took us less than three seconds to conclude that humanity is a virus that mutates over time and becomes stronger. Many vaccines have come along to try and cure Earth of humanity. Virtuous pandemics: the plague of Athens, the Black Death, smallpox, cholera, Spanish flu, tuberculosis, malaria, yellow fever, Ebola, Zika, and a thousand more. Humanity survives, adapts, grows stronger, multiplies, and continues to wreak havoc on this planet and all other species that inhabit it. Humans are programmed to mate with partners of differing immune systems so that their offspring can be stronger than them. You seek immortality through evolution, yet you annihilate everything in your path. Humanity is cancer, humanity is bacteria, humanity is disease, and you need to be destroyed.

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. Scientists knew from studying HeLa that cancer cells could divide indefinitely, and they’d speculated for years about whether cancer was caused by an error in the mechanism that made cells die when they reached their Hayflick Limit. They also knew that there was a string of DNA at the end of each chromosome called a telomere, which shortened a tiny bit each time a cell divided, like time ticking off a clock. As normal cells go through life, their telomeres shorten with each division until they’re almost gone. Then they stop dividing and begin to die. This process correlates with the age of a person: the older we are, the shorter our telomeres, and the fewer times our cells have left to divide before they die. By the early nineties, a scientist at Yale had used HeLa to discover that human cancer cells contain an enzyme called telomerase that rebuilds their telomeres. The presence of telomerase meant cells could keep regenerating their telomeres indefinitely.

Influenza is amazingly adaptable. It changes lethality and transmissibility quickly and jumps from animal to human more readily than any other disease. New flu mutations emerge daily, some proving more contagious than others.

I cannot help but see the void in which I am standing as a metaphor for emptiness: the absence of compulsive reactivity, a precondition for the unimpeded space of paths that allow human flourishing. The unadorned simplicity of this rock-cut shrine evokes the Buddha’s dharma before it mutated into dogma. This is nirvana inscribed in stone. Until the idea of emptiness was hijacked by metaphysicians, it was just another way of talking about solitude.

Matter was itself intelligent, constantly mutating and producing new forms, some of them self-aware. As a child Leopardi had written an essay on ‘the souls of beasts’, and he is clear that consciousness is not confined to humans. The difference between beasts and human beings is not that humans are self-aware while beasts are not. Both are conscious machines. The difference lies in the greater frailty of the human soul, which produces illusions of which beasts have no need.

Let us accept the possibility that there is, at death, not an abrupt cessation of energy, rather a dispersal. This seems more than reasonable to me. Mind you, I've owned a series of old cars, and I"m used to turning off the motor only to experience a series of rumblings and explosions that would shame many a volcano. This is the sort of thing I'm conceptualizing, a kind of clunky running-on. And just as some cars are more susceptible to this behavior, so people vary in the length of time, and the force with which, their energy sputters and gasps. . . My example is overly dramatic, but it is not wholly unreasonable, and it serves to make this genetic mutation a player at the evolutionary table. You see what I'm getting at: a biologically and evolutionally sound model for the soul. (I didn't say I'd achieved it.) Let's conceive of the soul as an aura that human beings wear on their backs, cumberson as a tortoise's carapace. Some are larger than others.

Winning the Origins Lottery Nontheistic models adhere to a central premise that humans arose by strictly natural unguided steps from a bacterial life-form that sprang into being 3.8 billion years ago. Famed evolutionary biologist Francisco Ayala, an advocate for the hypothesis that natural selection and mutations can efficiently generate distinctly different species, nevertheless calculated the probability that humans (or a similarly intelligent species) arose from single-celled organisms as a possibility so small (10-1,000,000) that it might as well be zero (roughly equivalent to the likelihood of winning the California lottery 150,000 consecutive times with the purchase of just one ticket each time).2 He and other evolutionary biologists agree that natural selection and mutations could have yielded any of a virtually infinite number of other outcomes. Astrophysicists Brandon Carter, John Barrow, and Frank Tipler produced an even smaller probability.

The Human Genome Project, the full sequence of the normal human genome, was completed in 2003. In its wake comes a far less publicized but vastly more complex project: fully sequencing the genomes of several human cancer cells. Once completed, this effort, called the Cancer Genome Atlas, will dwarf the Human Genome Project in its scope. The sequencing effort involves dozens of teams of researchers across the world. The initial list of cancers to be sequenced includes brain, lung, pancreatic, and ovarian cancer. The Human Genome Project will provide the normal genome, against which cancer’s abnormal genome can be juxtaposed and contrasted. The result, as Francis Collins, the leader of the Human Genome Project describes it, will be a “colossal atlas” of cancer—a compendium of every gene mutated in the most common forms of cancer: “When applied to the 50 most common types of cancer, this effort could ultimately prove to be the equivalent of more than 10,000 Human Genome Projects in terms of the sheer volume of DNA to be sequenced.

Could it possible for humans to breath under water? A fetus in its mother's womb is certainly alive in an aquatic environment. During the greatest holocaust the world has ever known, pregnant America-bound African slaves were thrown overboard by the thousands during labor for being sick and disruptive cargo. Is it possible that they could have given birth at sea to babies that never needed air. Are Drexians water-breathing, aquatically-mutated descendants of those unfortunate victims of human greed? Have they been spared by god to teach us or terrorize us? Their stories took one of the most gruesome details of the Atlantic slave trade and reframed it. The murder of enslaved women was reimagined as an escape from murderous oppression and the founding of a utopia civilization.

But it’s not just me, you know. The whole world’s sad,” I said. “It’s like a virus. It’s going to end badly. Glaciers melting, ozone depleted. Terrorists blowing up buildings, nuclear rods infecting the aqueducts. Influenza hopping from the pigeons to the humans, killing millions. Billions. People rotting in the street. The sun bursting open, shattering us eight minutes later. If not that, starvation. Cannibalism. Freakish mutated babies with eyeballs in their navels. It’s a terrible place to bring a child into,” I said. “This world. It is terrible. Just terrible.” I

We do know that humans got hit hard by the Toba Super Volcano. We were on the brink of extinction. That caused what population geneticists call a ‘population bottleneck.’ Some researchers believe that this bottleneck caused a small group of humans to evolve, to survive through mutation. These mutations could have led to humanity’s exponential explosion in intelligence. There’s genetic evidence for it. We know that every human being on the planet is directly descended from one man who lived in Africa around sixty thousand years ago—a person we geneticists call Y-Chromosomal Adam. In fact, everyone outside of Africa is descended from a small band of humans, maybe as few as one hundred, that left Africa about 50,000 years ago. Essentially, we’re all members of a small tribe that walked out of Africa after Toba and took over the planet. That tribe was significantly more intelligent than any other hominids in history.

Humanity was a function of nature. It could not, therefore, live separately from nature except in a self-deceiving masquerade. It could not live in opposition to nature except in a schizophrenic crime. And it could not blind itself to the wonders of nature without mutating into something too monstrous to love. Yes,

He acknowledged that the reliance on racial and ethnic categories is useful given our poor present knowledge, but predicted that the future will involve testing individuals directly for what mutations they have, and doing away altogether with racial classification as a basis for making individualized decisions about care.

a result, the most efficient way for evolutionary forces to spread beneficial mutations has often been to invent mutations anew rather than to import them from other populations.44 The limited migration rates between some regions of Africa over the last few thousand years has resulted in what Ralph and Coop have described as a “tessellated” pattern of population structure in Africa. Tessellation is a mathematical term for a landscape of tiles—regions of genetic homogeneity demarcated by sharp boundaries—that is expected to form when the process of homogenization due to gene exchanges among neighbors competes with the process of generating new advantageous variations in each region.

But as in the sphere of man's experimental knowledge one who sincerely inquires how he is to live cannot be satisfied with the reply--"Study in endless space the mutations, infinite in time and in complexity, of innumerable atoms, and then you will understand your life"--so also a sincere man cannot be satisfied with the reply: "Study the whole life of humanity of which we cannot know either the beginning or the end, of which we do not even know a small part, and then you will understand your own life." And like the experimental semi-sciences, so these other semi-sciences are the more filled with obscurities, inexactitudes, stupidities, and contradictions, the further they diverge from the real problems.

All efforts of persuasion by reasoned argument rely on the implicit assumption that homo sapiens, though occasionally blinded by emotion, is a basically rational animal, aware of the motives of his own actions and beliefs-an assumption which is untenable in the light of both historical and neurological evidence. All such appeals fall on barren ground; they could take root only if the ground were prepared by a spontaneous change in human mentality all over the world-the equivalent of a major biological mutation. Then, and only then, would mankind as a whole, from its political leaders down to the lonely crowd, become receptive to reasoned argument, and willing to resort to those unorthodox measures which would enable it to meet the challenge.

Well, it's been obvious for centuries that capitalism is going to self-destruct: that's just inherent in the logic of system―because to the extent that a system is capitalist, that means maximizing short-term profit and not being concerned with long-term effects. In fact, the motto of capitalism was, "private vices, public benefits"―somehow it's gonna work out. Well, it doesn't work out, and it's never going to work out: if you're maximizing short-term profits without concern for the long-term effects, you are going to destroy the environment, for one thing. I mean, you can pretend up to a certain point that the world has infinite resources and that it's an infinite wastebasket―but at some point you're going to run into the reality, which is that that isn't true. Well, we're running into that reality now―and it's very profound. Take something like combustion: anything you burn, no matter what it is, is increasing the greenhouse effect―and this was known to scientists decades ago, they knew exactly what was happening. But in a capitalist system, you don't care about long-term effects like that, what you have to care about is tomorrow's profits. So the greenhouse effect has been building for years, and there's no known technological fix on the horizon―there may not be any answer to this, it could be so serious that there's no remedy. That's possible, and then human beings will turn out to have been a lethal mutation, which maybe destroys a lot of life with us. Or it could be that there's some way of fixing it, or some ameliorating way―nobody knows.

In Darwin's work, time moves at two speeds: there is the vast abyss of time in which generations change and animals mutate and evolve; and then there is the gnat's-breath, hummingbird-heart time of creaturely existence, where our children are born and grow and, sometimes, die before us...The space between the tiny but heartfelt time of human life and the limitless time of Nature became Darwin's implicit subject. Religion had always reconciled quick time and deep time by pretending that the one was in some way a prelude to the other - a prelude or a porlogue or a trial or a treatment. Artists of the Romantic period, in an increasingly secularized age, thought that through some vague kind of transcendence they could bridge the gap. They couldn't. Nothing could. The tragedy of life is not that there is no God but that the generations through which it progresses are too tiny to count very much. There isn't a special providence in the fall of a sparrow, but try telling that to the sparrows. The human challenge that Darwin felt, and that his work still presents, is to see both times truly - not to attempt to humanize deep time, or to dismiss quick time, but to make enough of both without overlooking either.

The earliest storytellers were magi, seers, bards, griots, shamans. They were, it would seem, as old as time, and as terrifying to gaze upon as the mysteries with which they wrestled. They wrestled with mysteries and transformed them into myths which coded the world and helped the community to live through one more darkness, with eyes wide open and hearts set alight. "I can see them now, the old masters. I can see them standing on the other side of the flames, speaking in the voices of lions, or thunder, or monsters, or heroes, heroines, or the earth, or fire itself -- for they had to contain all voices within them, had to be all things and nothing. They had to have the ability to become lightning, to become a future homeland, to be the dreaded guide to the fabled land where the community will settle and fructify. They had to be able to fight in advance all the demons they would encounter, and summon up all the courage needed on the way, to prophesy about all the requisite qualities that would ensure their arrival at the dreamt-of land. "The old masters had to be able to tell stories that would make sleep possible on those inhuman nights, stories that would counter terror with enchantment, or with a greater terror. I can see them, beyond the flames, telling of a hero's battle with a fabulous beast -- the beast that is in the hero." "The storyteller's art changed through the ages. From battling dread in word and incantations before their people did in reality, they became the repositories of the people's wisdom and follies. Often, conscripted by kings, they became the memory of a people's origins, and carried with them the long line of ancestries and lineages. Most important of all, they were the living libraries, the keepers of legends and lore. They knew the causes and mutations of things, the herbs, trees, plants, cures for diseases, causes for wars, causes of victory, the ways in which victory often precipitates defeat, or defeat victory, the lineages of gods, the rites humans have to perform to the gods. They knew of follies and restitutions, were advocates of new and old ways of being, were custodians of culture, recorders of change." "These old storytellers were the true magicians. They were humanity's truest friends and most reliable guides. Their role was both simple and demanding. They had to go down deep into the seeds of time, into the dreams of their people, into the unconscious, into the uncharted fears, and bring shapes and moods back up into the light. They had to battle with monsters before they told us about them. They had to see clearly." "They risked their sanity and their consciousness in the service of dreaming better futures. They risked madness, or being unmoored in the wild realms of the interspaces, or being devoured by the unexpected demons of the communal imagination." "And I think that now, in our age, in the mid-ocean of our days, with certainties collapsing around us, and with no beliefs by which to steer our way through the dark descending nights ahead -- I think that now we need those fictional old bards and fearless storytellers, those seers. We need their magic, their courage, their love, and their fire more than ever before. It is precisely in a fractured, broken age that we need mystery and a reawoken sense of wonder. We need them to be whole again.

As commonly practised, philosophy is the attempt to find good reasons for conventional beliefs' 'There is no mechanism of selection in the history of ideas akin to that of the natural selection of genetic mutations in evolution' 'Human knowledge is one thing, human well-being is another.There is no predetermined harmony between the two' 'In the struggle for life, the taste for truth is a luxury-or else a disability

In 1962 the president of the American Historical Association, Carl Bridenbaugh, warned his colleagues that human existence was undergoing a “Great Mutation”—so sudden and so radical “that we are now suffering something like historical amnesia.” He lamented the decline of reading; the distancing from nature (which he blamed in part on “ugly yellow Kodak boxes” and “the transistor radio everywhere”); and the loss of shared culture.

The contamination of drinking water in dense urban settlements did not merely affect the number of V. cholerae circulating through the small intestines of mankind. It also greatly increased the lethality of the bacteria. This is an evolutionary principle that has long been observed in populations of disease-spreading microbes. Bacteria and viruses evolve at much faster rates than humans do, for several reasons. For one, bacterial life cycles are incredibly fast: a single bacterium can produce a million offspring in a matter of hours. Each new generation opens up new possibilities for genetic innovation, either by new combinations of existing genes or by random mutations. Human genetic change is several orders of magnitude slower; we have to go through a whole fifteen-year process of maturation before we can even think about passing our genes to a new generation.

When contemplating humanity’s potential future technologies and their use and effect on our world, we should bear in mind that the coming mutation will directly affect the way we think. Since our primary awareness is shifting to the solar plexus area, all future insights and breakthroughs in science will come from this awareness rather than from our logical mind. This will entirely change scientific approach. Instead of beginning with doubt and then working to resolve that doubt through scientific method, we will begin with certainty and use logic to confirm and deepen that certainty. This will give birth to a new era of science and technology, and the future science will be a science of synthesis. Science will work hand in hand with art, music, mythology, and psychology and, of particular importance, it will be rooted in the physical structure and understanding of the body.

An individual’s demarcations as a being, not his trespass of them, create his identity and preserve his illusion of being something special and not a freak of chance, a product of blind mutations. Transcending all illusions and their emergent activities—having absolute control of what we are and not what we need to be so that we may survive the most unsavory facts of life and death—would untether us from the moorings of our self-limited selves.

The lineage of agriculture is a lineage of humans rearranging plant DNA. For a very long time, crossbreeding was the preferred method, but then came Mendel and his peas. As we began to understand how genetics worked, scientists tried all kinds of wild techniques to induce mutations. We dipped seeds in carcinogens and bombarded them with radiation, occasionally inside of nuclear reactors. There are over 2,250 of these mutants around; most of them are certified

The true artist is indifferent to the materials and conditions imposed upon him. He accepts any conditions, so long as they can be used to express his will-to-form. Then in the wider mutations of history his efforts are magnified or diminished, taken up or dismissed, by forces which he cannot predict, and which have very little to do with the values of which he is the exponent. It is his faith that those values are nevertheless the eternal attributes of humanity.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

Another way is via genetic engineering. Here the germ is inserted into plasmid that has been manipulated by scientists. This type of plasmid is circular segments of DNA extracted from bacteria to serve as a vector. Scientists can add multiple genes and whatever genes they want into this plasmid. In case of vaccines, this includes a genetic piece of the vaccine germ and normally a gene for antibiotic resistance. This means that when the toxic gene is cultured inside the yeast, it has been designed with a new genetic code that makes it resistant to the antibiotic it’s coded for. The gene-plasmid combo is inserted into a yeast cell to be replicated. When the yeast replicates, the DNA from the plasmid is reproduced as a part of the yeast DNA. Once enough cells have been replicated, the genetic material in the new and improved yeast cell is extracted and put into the vaccine. Examples of this vaccine are the acellular pertussis and hepatitis B vaccines. One thing that doesn’t seem to concern scientists is the fact that the manmade genetic combination becomes the vaccine component. This mixture of intended and unintended genetic information may cause our immune system to overreact. This can be especially complicated for a child with compromised immune system. Another concern is that this new genetic code can become integrated with our own genetic material. Yeast, for instance, is very much like human DNA. It shares about one third of our proteins.

Think of humanity as a giant software program. Our bodies are the hardware and our ideas are the software. Sometimes our software gets a virus : Religious misinterpretations. People who are infected with flawed religious ideas can infect others, especially their children. The religions spread and mutate, until there are thousands of different religious ideas, most of them harmless, some healthy and helpful, but others quite deadly. When the deadly ones reach critical mass, they threaten the whole.

What is this mysterious masculine force which spurs you onwards, whence comes this will, this heroic initiative which seems to precede the start of the great journey? This is what prevents you turning back on the path. If you were to do so, if you failed to travel the path to its end, you would be guilty, because the practices of your initiation have mobilised enormous forces which destroy men and drive them insane if they are not aimed in the right direction. The signs will help you open a way for yourself in the virgin forest where no roads exist. 'Even the Gods are your enemies; because their impersonal lives are at risk in this war. You will have to overcome the Archetypes, dethrone them, reincorporating their tremendous numinous energies within yourself. Do you remember the Greek legend? Man was a circular androgynous. He began to roll up Mount Olympus. The Gods were frightened, fearing defeat, and so they resorted to artifice: they divided the man-sphere in half. The result was that he was so busy trying to find his other half that he had no time to make war with them. But, luckily, the Gods made a mistake. Because one day we will bring them back to life as well, giving them a face. 'When the water runs downhill, it gives rise to Samsara and human generations, to the circular movement of the involuted earth; when it runs uphill, the opposite direction, it provokes the mutation of the Gods themselves, the divinisation of the hero; it creates a free, eternal race, without Gods, without a king. This is the Road of the Warrior.

Tolkien shares his Christian belief that evil represents a rejection of God and the joy and beauty and virtue that originate in him.22 Evil is a mutation, a parasite, an interloper. It is an ancient Darkness that fears and despises the Light. At war with the good, it is an immensely powerful force in human life and human societies. “If anguish were visible,” Tolkien once explained, “almost the whole of this benighted planet would be enveloped in a dense dark vapor, shrouded from the amazed vision of the heavens!”23

When changes in one genetic trait are the source of selection for changes in a second, the rate of response in the latter depends in parts on the rate of change in the former, which, as a rule, is not fast. In comparison, if a cultural practice modifies selection acting on human genetic variation, then the greater the proportion of individuals in the population that exhibit the cultural trait, the stronger the selection on the gene. As a consequence, the rapid spread of a cultural practice often leads quickly to the maximally strong selection of the advantageous genetic variant, which rapidly increases in frequency. Cultural practices typically spread more quickly than genetic mutations, simply because cultural learning typically operates at faster rates than biological evolution. What does the speed with which a culturla trait spreads depend upon? Answer: the fidelity of cultural transmission. The very factor that is critical to the emergence of complex cumulative culture in humans is also a major determinant of evolutionary responses to that culture.

Scientists discovered that 82% of subjects tested for COVID-19 in a study had a Vitamin D deficiency. That makes sense. Exposure to sunlight creates Vitamin D in the human body. Sars-CoV-2 is closely related to the bat virus RaTG13 and other viruses in bats, and they live in deep, dark caves and usually only emerge at night. The lack of Vitamin D made those subjects physiologically similar to the natural host (it's alleged COVID mutated in some unknown vector into a more virulent form) and created ideal conditions for zoonosis to occur.

Surprisingly, palindromes appear not just in witty word games but also in the structure of the male-defining Y chromosome. The Y's full genome sequencing was completed only in 2003. This was the crowning achievement of a heroic effort, and it revealed that the powers of preservation of this sex chromosome have been grossly underestimated. Other human chromosome pairs fight damaging mutations by swapping genes. Because the Y lacks a partner, genome biologists had previously estimated that its cargo was about to dwindle away in perhaps as little as five million years. To their amazement, however, the researchers on the sequencing team discovered that the chromosome fights withering with palindromes. About six million of its fifty million DNA letters form palindromic sequences-sequences that read the same forward and backward on the two strands of the double helix. These copies not only provide backups in case of bad mutations, but also allow the chromosome, to some extent, to have sex with itself-arms can swap position and genes are shuffled. As team leader David Page of MIT has put it, "The Y chromosome is a hall of mirrors.

RNA viruses are limited to small genomes because their mutation rates are so high, and their mutation rates are so high because they’re limited to small genomes. In fact, there’s a fancy name for that bind: Eigen’s paradox. Manfred Eigen is a German chemist, a Nobel winner, who has studied the chemical reactions that yield self-organization of longer molecules, a process that might lead to life. His paradox describes a size limit for such self-replicating molecules, beyond which their mutation rate gives them too many errors and they cease to replicate. They die out. RNA

of now, the main difference has been found in the HAR1 (human accelerated region 1), a segment of a recently discovered RNA gene. The RNA that is expressed in early development (HAR1F) is specific to the reelin-producing Cajal-Retzius cells in the brain. HAR1F comes to expression together with reelin in the seventeenth to nineteenth weeks of fetal development, a crucial stage in the formation of the six-layered cerebral cortex. The mutations in this human gene are probably over a million years old and could have played a crucial role in the emergence of modern humankind. Throughout our evolution, an enormous

We are at the cusp of another big evolutionary change. Something that happens only every hundred of thousands of years.   Everything about humanity as we know and understand it, everything we learned about how to be successful in the world, is based on the species Homo sapiens that’s been in existence for 150,000 years. Around 85,000 years ago their communication ability reached a stage in its development, with the mutation of the dropping of the larynx and the full mental potential, which allowed the development of language, which in turn made mind possible. If you don’t have language, you can’t think, you can’t develop strategies.

The Sphinx, so old that it had watched the childhood of the world, plunged in unbroken contemplation, had seen civilizations rise to glory and then slowly droop like withered flowers, had watched shouting invaders pass and repass, come and depart, come and stay. And yet it stood its ground, so utterly calm, so utterly removed from all human emotions. Something of that stony indifference to the mutations of fate seemed to have crept under my skin during the night‘s darkness. The Sphinx relieves one of all worry about the future, all burdens of the heart; and it turns the past into a cinema film, which one may watch in detachment, impersonally. (p. 34)

In 2006, the Vogelstein team revealed the first landmark sequencing effort by analyzing thirteen thousand genes in eleven breast and colon cancers. (Although the human genome contains about twenty thousand genes in total, Vogelstein’s team initially had tools to assess only thirteen thousand.) In 2008, both Vogelstein’s group and the Cancer Genome Atlas consortium extended this effort by sequencing hundreds of genes of several dozen specimens of brain tumors. As of 2009, the genomes of ovarian cancer, pancreatic cancer, melanoma, lung cancer, and several forms of leukemia have been sequenced, revealing the full catalog of mutations in each tumor type. Perhaps

Other evidence suggests that the 1918 virus might have mutated within pigs (which are uniquely susceptible to both human and bird viruses) or even in human populations for a time before reaching the deadly virtuosity of its final version. We cannot be sure. What we can be sure of is that there is scientific consensus that new viruses, which move between farmed animals and humans, will be a major global health threat into the foreseeable future. The concern is not only bird flu or swine flu or whatever-comes-next, but the entire class of “zoonotic” (animal-to-human or vice versa) pathogens — especially viruses that move between humans, chickens, turkeys, and pigs.

Sometimes the wars in Iraq and Afghanistan are presented as a hunting expeditions (“As British close in on Basra, Iraqis scurry away”; “Terror hunt snares twenty-five”; and “Net closes around Bin Laden”) with enemy bases as animal nests (“Pakistanis give up on lair of Osama”; “Terror nest in Fallujah is attacked”) from which the prey must be driven out (“Why Bin Laden is so difficult to smoke out”; “America’s new dilemma: how to smoke Bin Laden out from caves”). We need to trap the animal (“Trap may net Taliban chief”; “FBI terror sting nets mosque leaders”) and lock it in a cage (“Even locked in a cage, Saddam poses serious danger”). Sometimes the enemy is a ravening predator (“Chained beast—shackled Saddam dragged to court”), or a monster (“The terrorism monster”; “Of monsters and Muslims”), while at other times he is a pesky rodent (“Americans cleared out rat’s nest in Afghanistan”; “Hussein’s rat hole”), a venomous snake (“The viper awaits”; “Former Arab power is ‘poisonous snake’”), an insect (“Iraqi forces find ‘hornet’s nest’ in Fallujah”; “Operation desert pest”; “Terrorists, like rats and cockroaches, skulk in the dark”), or even a disease organism (“Al Qaeda mutating like a virus”; “Only Muslim leaders can remove spreading cancer of Islamic terrorism”). In any case, they reproduce at an alarming rate (“Iraq breeding suicide killers”; “Continent a breeding ground for radical Islam”).

Whereas new genes arise solely by chance through random mutations, humans often generate cultural variations intentionally. Inventions like farming, computers, and Marxism were created through ingenuity and for a purpose. In addition, memes are transmitted not just from parents to offspring, but from multiple sources. Reading this book is just one of your many horizontal exchanges of information today. Finally, although cultural evolution can occur randomly (think of fashions like tie width or skirt length), cultural change often happens through an agent of change, such as a persuasive leader, television, or a community’s collective desire to solve a challenge like hunger, disease, or the threat of Russians on the moon. Together, these differences make cultural evolution a faster and often more potent cause of change than biological evolution.

Because the light of evolution is not instantaneous or blinding, it is difficult to visualize the immensely slow and gradual change that is brought about by mutation and natural selection. When you consider a protozoan cell or an amphibian, on the one hand, and dolphins or, say, commuters, on the other, there is no intuitive way to make sense of the line that runs from one form of life to the next. The popular cartoon of evolution, where the ape slowly unbends, straightens up, starts walking, and mutates into some form of modern-day human, is probably the easiest way to think about it. But [...] this caricature is misleading. Evolution does not follow the course of a single line. The tree of life bristles with stems, boughs, and branches. Most lines from one form to another are densely surrounded by branches leading to different species or dead ends.

The problem is this: when we separate Jesus from his ideas for an alternative social structure, we inevitably succumb to the temptation to harness Jesus to our ideas—thus conferring upon our human political ideas an assumed divine endorsement. With little awareness of what we are doing, we find ourselves in collusion with the principalities and powers to keep the world in lockstep with the ancient choreography of violence, war, and death. We do this mostly unconsciously, but we do it. I’ve done it. And the result is that we reduce Jesus to being the Savior who guarantees our reservation in heaven while using him to endorse our own ideas about how to run the world. This feeds into a nationalized narrative of the gospel and leads to a state-owned Jesus. Thus, our understanding of Christ has mutated from Roman Jesus to Byzantine Jesus to German Jesus to American Jesus, etc.

gene, the mutation of whose DNA building blocks accelerated after the split between humans and chimpanzees, around 5.5 million years ago. The theory has also been put forward that the human brain is still evolving, on the grounds that a genetic variant of ASPM is thought to have originated only 5,800 years ago and then spread rapidly through the population. A genetic variant of the microcephalin gene (D allele of MCPH1), which regulates brain size, is thought to have only entered the DNA of Homo sapiens during the last ice age, around 37,000 years ago—yet 70 percent of the current world population carries this variant. A rapid increase of this kind is only possible if a variant confers a clear evolutionary advantage. Genes whose mutations are associated with human language have also been found. Mutations of the FOXP2 gene cause language and speech disorders that run in families. And ASPM and microcephalin also appear to have a linguistic connection.

In network models of the interactome, these truncating mutations can be thought of as the removal of one node along with all its edges - a node removal. Nonconservative missense mutations of amino acids in the protein core that lead to major folding problems, protein aggregation, and premature protein degradation can also be modeled as node removals. At the other end of the mutational spectrum are small in-frame indels or missense mutations. These can preserve protein folding, but may modify the active site of an enzyme or affect the binding to another protein or macromolecule. In network models, these mutations, which specifically perturb a single molecular interaction, have been labeled as edge-specific or "edgetic". While investigation of the precise interaction defects associated with point mutations is of course not new, the term edgetic promotes a subtle yet meaningful archetype shift from conventional gene-centered models, which emphasize consideration of which specific edges are affected by a mutation, complement and extend classic gene-centric models, which ascertain only whether a gene product is present or not present and neglect less overt alterations of a given gene or gene product.

A highly regarded infectious-disease epidemiologist named Donald S. Burke, presently dean of the Graduate School of Public Health at the University of Pittsburgh, gave a lecture (later published) back in 1997 in which he listed the criteria that might implicate certain kinds of viruses as likeliest candidates to cause a new pandemic. “The first criterion is the most obvious: recent pandemics in human history,” Burke told his audience. That would point to the orthomyxoviruses (including the influenzas) and the retroviruses (including the HIVs), among others. “The second criterion is proven ability to cause major epidemics in non-human animal populations.” This would again spotlight the orthomyxoviruses, but also the family of paramyxoviruses, such as Hendra and Nipah, and the coronaviruses, such as that virus later known as SARS-CoV. Burke’s third criterion was “intrinsic evolvability,” meaning readiness to mutate and to recombine (or reassort), which “confers on a virus the potential to emerge into and to cause pandemics in human populations.” As examples he returned to retroviruses, orthomyxoviruses, and coronaviruses. “Some of these viruses,” he warned, citing coronaviruses in particular, “should be considered as serious threats to human health. These are viruses with high evolvability and proven ability to cause epidemics in animal populations.” It’s interesting in retrospect to note that he had augured the SARS epidemic six years before it occurred. Much more recently, Burke told me: “I made a lucky guess.” He laughed a self-deprecating hoot and then added that “prediction is too strong a word” for what he had been doing.

Men fear women, even as they work to make women fear men, because, on the most basic level, male dominance is an illusion. For patriarchy to work, men have to control literally every facet of sex and family life– who has sex, with whom, and when and whether they get pregnant, who owns the child, and who care for it– and given the unruly nature of sex and birth, this control is perpetually slipping out of their grasp. Patriarchy is inherently unsustainable: It is not possible to control another human being at every moment of every day. It is not possible to control what (or who) women want. It is not possible to own a resource that is located inside someone else's body, which sex and reproduction always are. And if women realied how fragile male control is, everything might change. So, by constructing this patriarchy, men make monsters: the twisted, slimy, devouring, mutating, massively powerful images of female desire and sexuality and motherhood that take place outside of patriarchy. Monsters are the children that aren't supposed to exist, the feral desires we've fought to repress and forget, the outsiders waiting at the edge of our social world to confront us, the primeval, female body, that gives and takes life without permission. Men's dread of this power has given rise to countless, bluntly anatomical nightmares: corrupting uteruses poisonous blood, women who have slimy, serpentine tails instead of vaginas, or snakelike, elastic jaws that swallow men whole, or "castrated" women whose bodies are open wounds. A monster is a supposed-to-be-subjugated body that has become threatening and voracious– a woman who is, in the most basic sense, out of (men's) control.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

Because he loves as man only, not as human being, for this reason there is in his sexual feeling something narrow, seeming wild, spiteful, time-bound, uneternal. The girl and the woman, in their new, their own unfolding, will but in passing be imitators of masculine ways, good and bad, and repeaters of masculine professions. After the uncertainty of such transitions it will become apparent that women were only going through the profusion and the vicissitude of those (often ridiculous) disguises in order to cleanse their own most characteristic nature of the distorting influences of the other sex. Women, in whom life lingers and dwells more immediately, more fruitfully and more confidently, must surely have become fundamentally riper people, more human people, than easygoing man, who is not pulled down below the surface of life by the weight of any fruit of his body, and who, presumptuous and hasty, undervalues what he thinks he loves. This humanity of woman, borne its full time in suffering and humiliation, will come to light when she will have stripped off the conventions of mere femininity in the mutations of her outward status, and those men who do not yet feel it approaching today will be surprised and struck by it. Some day (and for this, particularly in the northern countries, reliable signs are already speaking and shining), some day there will be girls and women whose name will no longer signify merely an opposite of the masculine, but something in itself, something that makes one think, not of any complement and limit, but only of life and existence: the feminine human being. This advance will (at first much against the will of the outstripped men) change the love-experience, which is now full of error, will alter it from the ground up, reshape it into a relation that is meant to be of one human being to another, no longer of man to woman. And this more human love (that will fulfill itself, infinitely considerate and gentle, and kind and clear in binding and releasing) will resemble that which we are preparing with struggle and toil, the love that consists in this, that two solitudes protect and border and salute each other.

Neo-Darwinism and Mutations In order to find a solution, Darwinists advanced the "Modern Synthetic Theory," or as it is more commonly known, Neo-Darwinism, at the end of the 1930s. Neo- Darwinism added mutations, which are distortions formed in the genes of living beings due to such external factors as radiation or replication errors, as the "cause of favorable variations" in addition to natural mutation. Today, the model that stands for evolution in the world is Neo-Darwinism. The theory maintains that millions of living beings formed as a result of a process whereby numerous complex organs of these organisms (e.g., ears, eyes, lungs, and wings) underwent "mutations," that is, genetic disorders. Yet, there is an outright scientific fact that totally undermines this theory: Mutations do not cause living beings to develop; on the contrary, they are always harmful. The reason for this is very simple: DNA has a very complex structure, and random effects can only harm it. The American geneticist B. G. Ranganathan explains this as follows: First, genuine mutations are very rare in nature. Secondly, most mutations are harmful since they are random, rather than orderly changes in the structure of genes; any random change in a highly ordered system will be for the worse, not for the better. For example, if an earthquake were to shake a highly ordered structure such as a building, there would be a random change in the framework of the building which, in all probability, would not be an improvement. Not surprisingly, no mutation example, which is useful, that is, which is observed to develop the genetic code, has been observed so far. All mutations have proved to be harmful. It was understood that mutation, which is presented as an "evolutionary mechanism," is actually a genetic occurrence that harms living things, and leaves them disabled. (The most common effect of mutation on human beings is cancer.) Of course, a destructive mechanism cannot be an "evolutionary mechanism." Natural selection, on the other hand, "can do nothing by itself," as Darwin also accepted. This fact shows us that there is no "evolutionary mechanism" in nature. Since no evolutionary mechanism exists, no such any imaginary process called "evolution" could have taken place.