Hormone Related Quotes

So you love me," said Petra softly when the kiss ended. I'm a raging mass of hormones thet I'm too young to understand," said Bean. "You're a female of a closely related species. According to all the best primatologists, I really have no choice." That's nice," she said...

Doc begs me for the wires to fix the pump. We should at least keep putting the hormones in the water," he insists, "so that they don't start mating with relatives." "Most people don't want to commit incest," I say dryly.

Oxytocin, a hormone and neuropeptide ... plays a major role in attachment processes and serves several purposes: It causes women to go into labor, strengthens attachment, and ... [increases] trust and cooperation. We get a boost of oxytocin in our brain during orgasm and even when we cuddle -- which is why it's been tagged the "cuddle hormone." How is oxytocin related to conflict reduction? Sometimes we spend less quality time with our partner -- especially when other demands on us are pressing. However, neuroscience findings suggest that we should change our priorities. By forgoing closeness with our partners, we are also missing our oxytocin boost -- making us less agreeable to the world around us and more vulnerable to conflict.

I am often described to my irritation as a 'contrarian' and even had the title inflicted on me by the publisher of one of my early books. (At least on that occasion I lived up to the title by ridiculing the word in my introduction to the book's first chapter.) It is actually a pity that our culture doesn't have a good vernacular word for an oppositionist or even for someone who tries to do his own thinking: the word 'dissident' can't be self-conferred because it is really a title of honor that has to be won or earned, while terms like 'gadfly' or 'maverick' are somehow trivial and condescending as well as over-full of self-regard. And I've lost count of the number of memoirs by old comrades or ex-comrades that have titles like 'Against the Stream,' 'Against the Current,' 'Minority of One,' 'Breaking Ranks' and so forth—all of them lending point to Harold Rosenberg's withering remark about 'the herd of independent minds.' Even when I was quite young I disliked being called a 'rebel': it seemed to make the patronizing suggestion that 'questioning authority' was part of a 'phase' through which I would naturally go. On the contrary, I was a relatively well-behaved and well-mannered boy, and chose my battles with some deliberation rather than just thinking with my hormones.

The most common theory points to the fact that men are stronger than women and that they have used their greater physical power to force women into submission. A more subtle version of this claim argues that their strength allows men to monopolize tasks that demand hard manual labor, such as plowing and harvesting. This gives them control of food production, which in turn translates into political clout. There are two problems with this emphasis on muscle power. First, the statement that men are stronger is true only on average and only with regard to certain types of strength. Women are generally more resistant to hunger, disease, and fatigue than men. There are also many women who can run faster and lift heavier weights than many men. Furthermore, and most problematically for this theory, women have, throughout history, mainly been excluded from jobs that required little physical effort, such as the priesthood, law, and politics, while engaging in hard manual labor in the fields....and in the household. If social power were divided in direct relation to physical strength or stamina, women should have got far more of it. Even more importantly, there simply is no direct relation between physical strength and social power among humans. People in their sixties usually exercise power over people in their twenties, even though twenty-somethings are much stronger than their elders. ...Boxing matches were not used to select Egyptian pharaohs or Catholic popes. In forager societies, political dominance generally resides with the person possessing the best social skills rather than the most developed musculature. In fact, human history shows that there is often an inverse relation between physical prowess and social power. In most societies, it’s the lower classes who do the manual labor. Another theory explains that masculine dominance results not from strength but from aggression. Millions of years of evolution have made men far more violent than women. Women can match men as far as hatred, greed, and abuse are concern, but when push comes to shove…men are more willing to engage in raw physical violence. This is why, throughout history, warfare has been a masculine prerogative. In times of war, men’s control of the armed forces has made them the masters of civilian society too. They then use their control of civilian society to fight more and more wars. …Recent studies of the hormonal and cognitive systems of men and women strengthen the assumption that men indeed have more aggressive and violent tendencies and are…on average, better suited to serve as common soldiers. Yet, granted that the common soldiers are all men, does it follow that the ones managing the war and enjoying its fruits must also be men? That makes no sense. It’s like assuming that because all the slaves cultivating cotton fields are all Black, plantation owners will be Black as well. Just as an all-Black workforce might be controlled by an all-White management, why couldn’t an all-male soldiery be controlled by an all-female government?

I was (an am) unsure about how I am related to my old self, or to myself from year to year. The hormonal profile of an individual determines much of the manifest personality. If you skew the endocrine system,you loose the pathways to the self. When endocrine patterns change it alters the way you think and feel. One shift in the pattern tends to trip another.

There was something awful about feeling rage and wanting to strangle something but instead falling prey to the softness of hormones, welling up with the inadequacy of sadness when what she meant to do was scream.

Relatively small changes in genes, hormones and neurons were enough to transform Homo erectus – who could produce nothing more impressive than flint knives – into Homo sapiens, who produce spaceships and computers.

Phosphatidylserine is a natural constituent of the cell membrane but is found in especially high concentrations in the brain. Supplementing with phosphatidylserine slows down memory loss and has been shown to reverse memory loss in some patients with age-related memory decline. It also lowers levels of cortisol, a principal hormone of aging.

The study reported a 24 percent relative increase in the risk of breast cancer among a subset of women taking HRT, and headlines all over the world condemned HRT as a dangerous, cancer-causing therapy. All of a sudden, on the basis of this one study, hormone replacement treatment became virtually taboo. This reported 24 percent risk increase sounded scary indeed. But nobody seemed to care that the absolute risk increase of breast cancer for women in the study remained minuscule. Roughly five out of every one thousand women in the HRT group developed breast cancer, versus four out of every one thousand in the control group, who received no hormones.

Next is diet or nutrition—or as I prefer to call it, nutritional biochemistry. The third domain is sleep, which has gone underappreciated by Medicine 2.0 until relatively recently. The fourth domain encompasses a set of tools and techniques to manage and improve emotional health. Our fifth and final domain consists of the various drugs, supplements, and hormones that doctors learn about in medical school and beyond. I lump these into one bucket called exogenous molecules, meaning molecules we ingest that come from outside the body.

Sex Games: What Men Really Think About Sex Partners (Sexuality, Cheating

Well,’ Elodie said with a sigh, ‘since Hannah has successfully ruined the appetites of her male relatives, that means more dessert for us girls. We’re having sticky toffee pudding and ice cream.’ ‘Och … well … you know, I’m feeling much better all of a sudden.’ Adam gestured to Braden, whose cheeks had warmed at the mention of dessert. ‘I could go for some pudding.’ Braden nodded solemnly. ‘Funnily enough, me too.’ Determined to stock up on good food before I returned to my diet-food-laden fridge back at the flat, I wasn’t sure I wanted to share pudding with the boys. No, I wasn’t sure about that at all. I looked over at Hannah and asked evilly, ‘What was that about boobs and hormones?

In fact, according to physicians, the functioning of the digestion depends less on the brain than on hormonal mechanisms and autoregulators. However, during a fast, the digestive system gets an increasing rest. About ten hours after a meal, the contractions stop and the feeling of hunger disappears; five or six hours later the glucose stops coming directly from the intestines and begins to produce itself from the reserve of glycogen contained in the liver. From then on, the body works on itself in a closed circuit, becoming itself the source of the energy it uses. Instead of destroying an appropriating to himself nourishment taken from outside, man enters a state of nonviolence and detachment relative to the outside world.

Your waist size is such an important predictor of health because the type of fat that is stored around your waistline—called “visceral fat” or “belly fat”—is related to the release of proteins and hormones that cause inflammation, which can in turn damage your arteries and affect how you metabolize sugars and fats. For this reason, visceral fat is strongly linked to type 2 diabetes, heart disease, stroke, Alzheimer’s, and other chronic diseases. Seeing your waist size come down is a great indicator of improving health.

The industrial and technological revolutions have made our lives simpler, in terms of what is physically required of us on a daily basis, but they have also made it possible for us to do a whole lot less than we ought to be doing, and we suffer for it. We have become flabby and overweight; our joints and muscles have become stiff from lack of use. We suffer from all sorts of problems related to our lack of physical exercise; it affects us on all levels, causing high blood pressure, increased cholesterol, anxiety, depression, insomnia and the list goes on and on. We know, too, how much better we feel for a bit of exercise. Those “feel-good” hormones lift our spirits, boost self-esteem and improve our overall sense of well-being. It’s a sort of built-in reward system. There’s a reason for that. It’s because we are meant to be active.

Finally, the stressor is over, the lion pursues some other pedestrian, you can return to your dinner plans. The various hormones of the stress-response turn off, your parasympathetic nervous system begins to slow down your heart via something called the vagus nerve, and your body calms down.

The defenders of feeling-based marriage venerate emotions for their authenticity only because they avoid looking closely at what actually floats through most people's emotional kaleidoscopes, all the contradictory, sentimental, and hormonal forces that pull us in a hundred often crazed and inconclusive directions. We could not be fulfilled if we weren't inauthentic some of the time—inauthentic, that is, in relation to such things as our passing desires to throttle our children, poison our spouse, or end our marriage over a dispute about changing a lightbulb. A degree of repression is necessary for both the mental health of our species and the adequate functioning of a decently ordered society. We are chaotic chemical propositions. We should feel grateful for, and protected by, the knowledge that our external circumstances are often out of line with what we feel; it is a sign that we are probably on the right course.

In recent years, there has been an explosion of research into meditation, which has been shown to: • Reduce blood pressure • Boost recovery after the release of the stress hormone cortisol • Improve immune system functioning and response • Slow age-related atrophy of the brain • Mitigate the symptoms of depression and anxiety

Stress can also prevent extinction from taking place.53 This is thought to be due to the fact that stressful events release the hormone cortisol via the pituitary-adrenal system (see Chapter 3); this hormone has impairing effects on PFCVM function.54 Thus, the very factor needed to induce extinction—exposure to stressful threats—can prevent extinction. This is an argument against the use of flooding and related exposure procedures that elicit high levels of “fear.” However, the hormones released during stress that impair extinction have complex and sometimes opposing effects on different phases of learning (acquisition, memory consolidation, memory retrieval, extinction, and memory reconsolidation).

That means to push very heavy weight, repeatedly, and to constantly strive to elevate both your baseline numbers and the total weight lifted at the workout—until you start to reach a natural limit relative to your competitive goals. This will deliver improvements in strength and subsequent improvements in endurance performance, and also maximize the hormonal, anti-aging benefits of the workout.

Hormonal responses to various fetal and childhood experiences have epigenetic effects on genes related to the growth factor BDNF, to the vasopressin and oxytocin system, and to estrogen sensitivity. These effects are pertinent to adult cognition, personality, emotionality, and psychiatric health. Childhood abuse, for example, causes epigenetic changes in hundreds of genes in the human hippocampus.

The neurological research shows something truly remarkable: If a person keeps taking the same substance, his or her brain keeps firing the same circuits in the same way—in effect, memorizing what the substance does. The person can easily become conditioned to the effect of a particular pill or injection from associating it with a familiar internal change from past experience. Because of this kind of conditioning, when the person then takes a placebo, the same hardwired circuits will fire as when he or she took the drug. An associative memory elicits a subconscious program that makes a connection between the pill or injection and the hormonal change in the body, and then the program automatically signals the body to make the related chemicals found in the drug. . . . Isn’t that amazing? Benedetti

Oxytocin and vasopressin are chemically similar hormones; the DNA sequences that constitute their genes are similar, and the two genes occur close to each other on the same chromosome. There was a single ancestral gene that, a few hundred million years ago, was accidentally “duplicated” in the genome, and the DNA sequences in the two copies of the gene drifted independently, evolving into two closely related genes

controlling insulin levels adequately such that serum insulin levels remain low. In this way, hormone-sensitive lipase is easier to activate, making mobilized bodyfat the body’s primary energy source preferentially over other sources. This state can be achieved through a diet that is relatively restricted in carbohydrates, but one will have more dietary latitude if, in concert with going easy on the carbohydrates, one engages in the performance of high-intensity exercise.

Michael Pollan: "The industrialization--and dehumanization--of American animal farming is a relatively new, evitable, and local phenomenon: no other country raises and slaughters its food animals quite as intensively or as brutally as we do." U.S. consumers may take our pick of reasons to be wary of the resulting product: growth hormones, antibiotic-resistant bacteria, unhealthy cholesterol composition, deadly E. coli strains, fuel consumption, concentration of manure into toxic waste lagoons, and the turpitude of keeping confined creatures at the limits of their physiological and psychological endurance.

For example, the euphoria brought on by DMT helped volunteers more unflinchingly look at their lives and conflicts. These ecstatic feelings may be, in part, related to the powerful DMT-induced surge of the morphinelike brain chemical beta-endorphin. DMT also stimulated a massive rise in the brain hormones vasopressin and prolactin. Scientists believe these compounds are important in feelings of bonding, attachment, and comfort with other members of the species. Perhaps the elevations in these brain chemicals made it easier for our volunteers to trust us, relax into the drug effects, and share powerfully personal issues in ways that previously were impossible.

Then I read from the Hite Report, published in 1976, from the chapter titled "Redefining Sex": Sex is intimate physical contact for pleasure, to share pleasure with another person (or just alone). You can have sex to orgasm, or not to orgasm, genital sex, or just physical intimacy- whatever seems right to you. There is never any reason to think the "goal" must be intercourse, and to try to make what you feel fit into that context. There is no standard of sexual performance "out there," against which you must measure yourself; you aren't ruled by "hormones" or "biology." You are free to explore and discover your own sexuality, to learn or unlearn anything you want, and to make physical relations with other people, of either sex, anything you like.

Our brains, for instance, are 70 percent fat, mostly in the form of a substance known as myelin that insulates nerve cells and, for that matter, all nerve endings in the body. Fat is the primary component of all cell membranes. Changing the proportion of saturated to unsaturated fats in the diet, as proponents of Keys’s hypothesis recommended, might well change the composition of the fats in the cell membranes. This could alter the permeability of cell membranes, which determines how easily they transport, among other things, blood sugar, proteins, hormones, bacteria, viruses, and tumor-causing agents into and out of the cell. The relative saturation of these membrane fats could affect the aging of cells and the likelihood that blood cells will clot in vessels and cause heart attacks.

Nobody is ever made happy by winning the lottery, buying a house, getting a promotion or even finding true love. People are made happy by one thing and one thing only – pleasant sensations in their bodies. A person who just won the lottery or found new love and jumps from joy is not really reacting to the money or the lover. She is reacting to various hormones coursing through her bloodstream and to the storm of electric signals flashing between different parts of her brain. Unfortunately for all hopes of creating heaven on earth, our internal biochemical system seems to be programmed to keep happiness levels relatively constant. There's no natural selection for happiness as such - a happy hermit's genetic line will go extinct as the genes of a pair of anxious parents get carried on to the next generation. Happiness and misery play a role in evolution only to the extent that they encourage or discourage survival and reproduction. Perhaps it's not surprising, then, that evolution has moulded us to be neither too miserable nor too happy. It enables us to enjoy a momentary rush of pleasant sensations, but these never last for ever. Sooner of later they subside and give place to unpleasant sensations. (...) Some scholars compare human biochemistry to an air-conditioning system that keeps the temperature constant, come heatwave or snowstorm. Events might momentarily change the temperature, but the air-conditioning system always returns the temperature to the same set point. Some air-conditioning systems are set at twenty-five degrees Celsius. Others are set at twenty degrees. Human happiness conditioning systems also differ from person to person. On a scale from one to ten, some people are born with a cheerful biochemical system that allows their mood to swing between levels six and ten, stabilising with time at eight. Such a person is quite happy even if she lives in an alienating big city, loses all her money in a stock-exchange crash and is diagnosed with diabetes. Other people are cursed with a gloomy biochemistry that swings between three and seven and stabilises at five. Such an unhappy person remains depressed even if she enjoys the support of a tight-knit community, wins millions in the lottery and is as healthy as an Olympic athlete (...) incapable of experiencing anything beyond level seven happiness. Her brain is simply not built for exhilaration, come what may. (...) Buying cars and writing novels do not change our biochemistry. They can startle it for a fleeting moment, but it is soon back to the set point.

By using two elephants to do the job, damage will occur just because of how large, lumbering, and unsubtle elephants are. They squash the flowers in the process of entering the playground, they strew leftovers and garbage all over the place from the frequent snacks they must eat while balancing the seesaw, they wear out the seesaw faster, and so on. This is equivalent to a pattern of stress-related disease that will run through many of the subsequent chapters: it is hard to fix one major problem in the body without knocking something else out of balance (the very essence of allostasis spreading across systems throughout the body). Thus, you may be able to solve one bit of imbalance brought on during stress by using your elephants (your massive levels of various stress hormones), but such great quantities of those hormones can make a mess of something else in the process. And a long history of doing this produces wear and tear throughout the body, termed allostatic load.

As the pumping engines for the circulatory system, ventricles must have a particular ovoid, lemonlike shape for strong, swift ejection of blood. If the end of the left ventricle balloons out, as it does in takotsubo hearts, the firm, healthy contractions are reduced to inefficient spasms—floppy and unpredictable. But what’s remarkable about takotsubo is what causes the bulge. Seeing a loved one die. Being left at the altar or losing your life savings with a bad roll of the dice. Intense, painful emotions in the brain can set off alarming, life-threatening physical changes in the heart. This new diagnosis was proof of the powerful connection between heart and mind. Takotsubo cardiomyopathy confirmed a relationship many doctors had considered more metaphoric than diagnostic. As a clinical cardiologist, I needed to know how to recognize and treat takotsubo cardiomyopathy. But years before pursuing cardiology, I had completed a residency in psychiatry at the UCLA Neuropsychiatric Institute. Having also trained as a psychiatrist, I was captivated by this syndrome, which lay at the intersection of my two professional passions. That background put me in a unique position that day at the zoo. I reflexively placed the human phenomenon side by side with the animal one. Emotional trigger … surge of stress hormones … failing heart muscle … possible death. An unexpected “aha!” suddenly hit me. Takotsubo in humans and the heart effects of capture myopathy in animals were almost certainly related—perhaps even the same syndrome with different names.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

Correlation and causality. Why is it that throughout the animal kingdom and in every human culture, males account for most aggression and violence? Well, what about testosterone and some related hormones, collectively called androgens, a term that unless otherwise noted, I will use simplistically as synonymous with testosterone. In nearly all species, males have more circulating testosterone than do females, who secrete small amounts of androgens from the adrenal glands. Moreover, male aggression is most prevalent when testosterone levels are highest; adolescence and during mating season in seasonal breeders. Thus, testosterone and aggression are linked. Furthermore, there are particularly high levels of testosterone receptors in the amygdala, in the way station by which it projects to the rest of the brain, the bed nucleus of the stria terminalis, and in its major targets, the hypothalamus, the central gray of the mid-brain, and the frontal cortex. But these are merely correlative data. Showing that testosterone causes aggression requires a subtraction plus a replacement experiment. Subtraction, castrate a male: do levels of aggression decrease? Yes, including in humans. This shows that something coming from the testes causes aggression. Is it testosterone? Replacement: give that castrated individual replacement testosterone. Do pre-castration levels of aggression return? Yes, including in humans, thus testosterone causes aggression. Time to see how wrong that is. The first hint of a complication comes after castration. When average levels of aggression plummet in every species, but crucially, not to zero, well, maybe the castration wasn't perfect, you missed some bits of testes, or maybe enough of the minor adrenal androgens are secreted to maintain the aggression. But no, even when testosterone and androgens are completely eliminated, some aggression remains, thus some male aggression is testosterone independent. This point is driven home by castration of some sexual offenders, a legal procedure in a few states. This is accomplished with chemical castration, administration of drugs that either inhibit testosterone production or block testosterone receptors. Castration decreases sexual urges in the subset of sex offenders with intense, obsessive, and pathological urges. But otherwise, castration doesn't decrease recidivism rates as stated in one meta-analysis. Hostile rapists and those who commit sex crimes motivated by power or anger are not amenable to treatment with the anti-androgenic drugs. This leads to a hugely informative point. The more experience the male had being aggressive prior to castration, the more aggression continues afterward. In otherwise, the less his being aggressive in the future requires testosterone and the more it's a function of social learning.

The Western medical model — and I don't mean the science of it, I mean the practice of it, because the science is completely at odds with the practice — makes two devastating separations. First of all we separate the mind from the body, we separate the emotions from the physiology. So we don't see how the physiology of people reflects their lifelong emotional experience. So we separate the mind from the body, which is not something that traditional medicine has done, I mean, Ayuverdic or Chinese medicine or shamanic tribal cultures and medicinal practices throughout the world have always recognized that mind and body are inseparable. They intuitively knew it. Many Western practitioners have known this and even taught it, but in practice we ignore it. And then we separate the individual from the environment. The studies are clear, for example, that when people are emotionally isolated they tend to get sick more quickly and they succumb more rapidly to their disease. Why? Because people's physiology is completely related to their psychological, social environment and when people are isolated and alone their stress levels are much higher because there's nothing there to help them moderate their stress. And physiologically it is straightforward, you know, it takes a five-year-old kid to understand it. However because in practice we separate them... when somebody shows up with an inflamed joint, all we do is we give them an anti-inflammatory or because the immune system is hyperactive and is attacking them we give them a medication to suppress their immune system or we give them a stress hormone like cortisol or one of its analogues, to suppress the inflammation. But we never ask: "What does this manifest about your life?", "What does this say about your relationships?", "How stressful is your job?", "To what extent do you lack control in your life?", "Where are you not authentic?", "How are you trying to work so hard to meet your attachment needs by suppressing yourself?" (because that is what you learn to do as a kid). Then we do all this research that has to do with cell biology, so we keep looking for the cause of cancer in the cell. Now there's a wonderful quote in the New York Times a couple of years ago they did a series on cancer and somebody said: "Looking for the cause of cancer inside the individual cell is like trying to understand a traffic jam by studying the internal combustion engine." We will never understand it, but we spend hundreds of billions of dollars a year looking for the cause of cancer inside the cell, not recognizing that the cell exists in interaction with the environment and that the genes are modulated by the environment, they are turned on and off by the environment. So the impact of not understanding the unity of emotions and physiology on one hand and in the other hand the relationship between the individual and the environment.. in other words.. having a strictly biological model as opposed to what has been called a bio-psycho-social, that recognizes that the biology is important, but it also reflects our psychological and social relationships. And therefore trying to understand the biology in isolation from the psychological and social environment is futile. The result is that we are treating people purely through pharmaceuticals or physical interventions, greatly to the profit of companies that manufacture pharmaceuticals and which fund the research, but it leaves us very much in the dark about a) the causes and b) the treatment, the holistic treatment of most conditions. So that for all our amazing interventions and technological marvels, we are still far short of doing what we could do, were we more mindful of that unity. So the consequences are devastating economically, they are devastating emotionally, they are devastating medically.

The traditional hospital practice of excluding parents ignored the importance of attachment relationships as regulators of the child’s emotions, behaviour and physiology. The child’s biological status would be vastly different under the circumstances of parental presence or absence. Her neurochemical output, the electrical activity in her brain’s emotional centres, her heart rate, blood pressure and the serum levels of the various hormones related to stress would all vary significantly. Life is possible only within certain well-defined limits, internal or external. We can no more survive, say, high sugar levels in our bloodstream than we can withstand high levels of radiation emanating from a nuclear explosion. The role of self-regulation, whether emotional or physical, may be likened to that of a thermostat ensuring that the temperature in a home remains constant despite the extremes of weather conditions outside. When the environment becomes too cold, the heating system is switched on. If the air becomes overheated, the air conditioner begins to work. In the animal kingdom, self-regulation is illustrated by the capacity of the warm-blooded creature to exist in a broad range of environments. It can survive more extreme variations of hot and cold without either chilling or overheating than can a coldblooded species. The latter is restricted to a much narrower range of habitats because it does not have the capacity to self-regulate the internal environment. Children and infant animals have virtually no capacity for biological self-regulation; their internal biological states—heart rates, hormone levels, nervous system activity — depend completely on their relationships with caregiving grown-ups. Emotions such as love, fear or anger serve the needs of protecting the self while maintaining essential relationships with parents and other caregivers. Psychological stress is whatever threatens the young creature’s perception of a safe relationship with the adults, because any disruption in the relationship will cause turbulence in the internal milieu. Emotional and social relationships remain important biological influences beyond childhood. “Independent self-regulation may not exist even in adulthood,” Dr. Myron Hofer, then of the Departments of Psychiatry and Neuroscience at Albert Einstein College of Medicine in New York, wrote in 1984. “Social interactions may continue to play an important role in the everyday regulation of internal biologic systems throughout life.” Our biological response to environmental challenge is profoundly influenced by the context and by the set of relationships that connect us with other human beings. As one prominent researcher has expressed it most aptly, “Adaptation does not occur wholly within the individual.” Human beings as a species did not evolve as solitary creatures but as social animals whose survival was contingent on powerful emotional connections with family and tribe. Social and emotional connections are an integral part of our neurological and chemical makeup. We all know this from the daily experience of dramatic physiological shifts in our bodies as we interact with others. “You’ve burnt the toast again,” evokes markedly different bodily responses from us, depending on whether it is shouted in anger or said with a smile. When one considers our evolutionary history and the scientific evidence at hand, it is absurd even to imagine that health and disease could ever be understood in isolation from our psychoemotional networks. “The basic premise is that, like other social animals, human physiologic homeostasis and ultimate health status are influenced not only by the physical environment but also by the social environment.” From such a biopsychosocial perspective, individual biology, psychological functioning and interpersonal and social relationships work together, each influencing the other.

Structurally, then, errors of love are similar to errors in general. Emotionally, however, they are in a league of their own: astounding, enduring, miserable, incomprehensible. True, certain other large-scale errors can rival or even dwarf them; we’ve gotten a taste of that in recent chapters. But relatively few of us will undergo, for example, the traumatic and total abandonment of a deeply held religious belief, or the wrongful identification of an assailant. By contrast, the vast majority of us will get our hearts seriously broken, quite possibly more than once. And when we do, we will experience not one but two kinds of wrongness about love. The first is a specific error about a specific person—the loss of faith in a relationship, whether it ended because our partner left us or because we grew disillusioned. But, as I’ve suggested, we will also find that we were wrong about love in a more general way: that we embraced an account of it that is manifestly implausible. The specific error might be the one that breaks our heart, but the general one noticeably compounds the heartache. A lover who is part of our very soul can’t be wrong for us, nor can we be wrong about her. A love that is eternal cannot end. And yet it does, and there we are—mired in a misery made all the more extreme by virtue of being unthinkable. We can’t do much about the specific error—the one in which we turn out to be wrong about (or wronged by) someone we once deeply loved. (In fact, this is a good example of a kind of error we can’t eliminate and shouldn’t want to.) But what about the general error? Why do we embrace a narrative of love that makes the demise of our relationships that much more shocking, humiliating, and painful? There are, after all, less romantic and more realistic narratives of love available to us: the cool biochemical one, say, where the only heroes are hormones; the implacable evolutionary one, where the communion of souls is supplanted by the transmission of genes; or just a slightly more world-weary one, where love is rewarding and worth it, but nonetheless unpredictable and possibly impermanent—Shakespeare’s wandering bark rather than his fixèd mark. Any of these would, at the very least, help brace us for the blow of love’s end. But at what price? Let go of the romantic notion of love, and we also relinquish the protection it purports to offer us against loneliness and despair. Love can’t bridge the gap between us and the world if it is, itself, evidence of that gap—just another fallible human theory, about ourselves, about the people we love, about the intimate “us” of a relationship. Whatever the cost, then, we must think of love as wholly removed from the earthly, imperfect realm of theory-making. Like the love of Aristophanes’ conjoined couples before they angered the gods, like the love of Adam and Eve before they were exiled from the Garden of Eden, we want our own love to predate and transcend the gap between us and the world.

Low Risk of Cardiovascular Disease - Less than 1 mg/L Moderate Risk of Cardiovascular Disease - 1 to 2.9 mg/L High Risk of Cardiovascular Disease - 3 or higher mg/L Further Testing Suggested to Find out the Cause of Severe Inflammation - 10 or higher mg/L CRP-HS (C-Reactive High Sensitivity) Lower Relative Risk - Less than 1.0 Average Relative Risk - Average Risk TSH (Thyroid Stimulating Hormone) Normal Range - 0.4 to 4.2 ml/L T4 (Free Thyroid) Normal Range - 0.78 to 2.19 ng/dL T4 (Total Thyroid) Normal Range – 5.53 to 11.00 mcg/dL T3 (Free Thyroid) Normal Range - 2.5 to 5.3 pg/mL SECTION 2

Normally, when sugar enters the bloodstream from our gut, the pancreas secretes insulin into the bloodstream, and the insulin then travels to three main places: fat cells, muscle cells, and neurons. Insulin’s primary job is to open the door to any cell to allow glucose to enter and provide fuel, particularly to three important types of cells. 1. IN FAT CELLS, insulin attaches to a docking port on a fat cell membrane and flips a switch that tells the fat cell to convert that glucose to fat and store it. When insulin has done its job, it separates from the docking port and no more sugar can enter the cell. 2. IN MUSCLE CELLS, insulin unlocks the door to the cell and ushers in glucose to be used as fuel. 3. NERVE CELLS (neurons) also require insulin to admit glucose through their cell membrane. The fact that neurons require insulin to get glucose is a relatively new finding, and we now know that insulin resistance also occurs in the brain and nerves—it is called type 3 diabetes. Once insulin docks in the appropriate ports and releases information, the fat, muscle, or nerve cells tell the hormone that the message has been received. The hormone then backs out of the docking port, leaving it ready and available for the next hormone to attach.

Many studies have found that people suffering from depression show unique symptoms in their bodies.9 These symptoms include too low amounts of various brain chemicals (norepinephrine, serotonin, and dopamine), a too high amount of a stress hormone (cortisol), and disturbance of deep dream-related (REM) sleep. Furthermore, new technologies allowing researchers to image the brain have revealed that severely depressed patients have abnormalities in the prefrontal cortex (the region of the brain responsible for thinking and managing emotions) as well as in the limbic regions (i.e., areas involved in sleep, eating, sex, motivation, memory, and responses to stress), including the mysterious-sounding Area 25.10 In sum, there is now a great deal of evidence that depression is partly rooted in those parts of our physical bodies over which we have minimal control.

Remember that for millions of years natural selection favored women who devoted whatever extra energy they had toward reproduction, partly through the action of reproductive hormones such as estrogen. Natural selection, however, never geared women's bodies for coping with long-term surfeits of energy, estrogen, and other related hormones. As a result, women today are very different and vastly more at risk of developing cancer than mothers from long ago because their bodies are still functioning as they evolved to have as many surviving children as possible.

There are four foundational chemicals/hormones that are often involved in our experience of sharing relational, glad-to-be-together joy with others.

Note: Dr. Lawrence Polinkis who analyzed clinical data from American men and women at Antarctica's Mcmurdo station Amundsen Scott's South Pole station posits specifically that the memory loss and other cognitive impairments he observed were related to a decline in levels of the thyroid hormone T3, which helps determine how the body uses energy. Thyroid hormones help the body regulate temperature and set its circadian rhythms. It's not difficult to see how extreme cold and the prolonged absence of sunshine might throw a system off. This is just a hypothesis - the causes of the syndrome remain puzzling more the a century after Cook first described it.

FAMILY VALUES If you start watching pigeons, one of the first things you’ll notice is that you never see a chick. Like some mythical beast, these birds reveal themselves to humans only after reaching maturity. There are two good reasons for this: First, pigeons are good at hiding their nests; and second, the young birds—called squabs—stay in the nest until they lose the obvious indicators of youth. They are able to do this because mother and father pigeon work together to provide for their young. This equality in parenting extends to milk production: Both males and females secrete a cheesy yellow milk into the crop, a food-storage pouch partway down the throat. I had thought that milk belonged exclusively to mammals; it’s our defining characteristic, so important that we are named for it—“mammal” comes from the Latin mamma, meaning breast. Pigeons are more closely related to dinosaurs than mammals. Like breast milk, pigeon milk contains antibodies and immune-system regulators. Like breast milk, it is stimulated by the hormone prolactin; in fact, scientists discovered prolactin while studying pigeons. Despite the similarities, mammal milk isn’t a relative of pigeon milk. Instead, it is an example of

The central function of the amygdala, which I call the brain’s smoke detector, is to identify whether incoming input is relevant for our survival.11 It does so quickly and automatically, with the help of feedback from the hippocampus, a nearby structure that relates the new input to past experiences. If the amygdala senses a threat—a potential collision with an oncoming vehicle, a person on the street who looks threatening—it sends an instant message down to the hypothalamus and the brain stem, recruiting the stress-hormone system and the autonomic nervous system (ANS) to orchestrate a whole-body response. Because the amygdala processes the information it receives from the thalamus faster than the frontal lobes do, it decides whether incoming information is a threat to our survival even before we are consciously aware of the danger. By the time we realize what is happening, our body may already be on the move.

There are many examples of how Medicine 2.0 gets risk wrong, but one of the most egregious has to do with hormone replacement therapy (HRT) for postmenopausal women, long entrenched as standard practice before the results of the Women’s Health Initiative Study (WHI) were published in 2002. This large clinical trial, involving thousands of older women, compared a multitude of health outcomes in women taking HRT versus those who did not take it. The study reported a 24 percent relative increase in the risk of breast cancer among a subset of women taking HRT, and headlines all over the world condemned HRT as a dangerous, cancer-causing therapy. All of a sudden, on the basis of this one study, hormone replacement treatment became virtually taboo. This reported 24 percent risk increase sounded scary indeed. But nobody seemed to care that the absolute risk increase of breast cancer for women in the study remained minuscule. Roughly five out of every one thousand women in the HRT group developed breast cancer, versus four out of every one thousand in the control group, who received no hormones. The absolute risk increase was just 0.1 percentage point. HRT was linked to, potentially, one additional case of breast cancer in every thousand patients. Yet this tiny increase in absolute risk was deemed to outweigh any benefits, meaning menopausal women would potentially be subject to hot flashes and night sweats, as well as loss of bone density and muscle mass, and other unpleasant symptoms

of menopause—not to mention a potentially increased risk of Alzheimer’s disease, as we’ll see in chapter 9. Medicine 2.0 would rather throw out this therapy entirely, on the basis of one clinical trial, than try to understand and address the nuances involved. Medicine 3.0 would take this study into account, while recognizing its inevitable limitations and built-in biases. The key question that Medicine 3.0 asks is whether this intervention, hormone replacement therapy, with its relatively small increase in average risk in a large group of women older than sixty-five, might still be net beneficial for our individual patient, with her own unique mix of symptoms and risk factors. How is she similar to or different from the population in the study? One huge difference: none of the women selected for the study were actually symptomatic, and most were many years out of menopause. So how applicable are the findings of this study to women who are in or just entering menopause (and are presumably younger)? Finally, is there some other possible explanation for the slight observed increase in risk with this specific HRT protocol?[*3] My broader point is that at the level of the individual patient, we should be willing to ask deeper questions of risk versus reward versus cost for this therapy—and for almost anything else we might do. The fourth and perhaps largest shift is that where Medicine 2.0 focuses largely on lifespan, and is almost entirely geared toward staving off death, Medicine 3.0 pays far more attention to maintaining healthspan, the quality of life. Healthspan was a concept that barely even existed when I went to medical school. My professors said little to nothing about how to help our patients maintain their physical and cognitive capacity as they aged. The word exercise was almost never uttered. Sleep was totally ignored, both in class and in residency, as we routinely worked twenty-four hours at a stretch. Our instruction in nutrition was also minimal to nonexistent. Today, Medicine 2.0 at least acknowledges the importance of healthspan, but the standard definition—the period of life free of disease or disability—is totally insufficient, in my view. We want more out of life than simply the absence of sickness or disability. We want to be thriving, in every way, throughout the latter half of our lives. Another, related issue is that longevity itself, and healthspan in particular, doesn’t really fit into the business model of our current

Your body reverses all of the storage steps through the release of the stress hormones glucocorticoids, glucagon, epinephrine, and norepinephrine. These cause triglycerides to be broken down in the fat cells and, as a result, free fatty acids and glycerol pour into the circulatory system.

How does chronic stress affect this process? First, the hormones of the stress-response cause even more glucose and fatty acids to be mobilized into the bloodstream. For a juvenile diabetic, this increases the likelihood of the now-familiar pathologies of glucose and fatty acids gumming up in the wrong places.

Another, more subtle problem occurs with chronic stress as well. When something stressful happens, you don’t just block insulin secretion. Basically, the brain doesn’t quite trust the pancreas not to keep secreting a little insulin, so a second step occurs. As noted earlier, during stress, glucocorticoids act on fat cells throughout the body to make them less sensitive to insulin, just in case there’s some still floating around. Fat cells then release some newly discovered hormones that get other tissues, like muscle and liver, to stop responding to insulin as well. Stress promotes insulin resistance.

You might recall from earlier chapters that the hormone CRH is released by the hypothalamus and, by stimulating the pituitary to release ACTH, starts the cascade of events that culminates in adrenal release of glucocorticoids.

(Steroid is used to describe the general chemical structure of five classes of hormones: androgens—the famed “anabolic” steroids like testosterone that get you thrown out of the Olympics—estrogens, progestins, mineralocorticoids, and glucocorticoids.)

Just as some glands are activated in response to stress, various hormonal systems are inhibited during stress. The secretion of various reproductive hormones such as estrogen, progesterone, and testosterone is inhibited. Hormones related to growth (such as growth hormone) are also inhibited, as is the secretion of insulin, a pancreatic hormone that normally tells your body to store energy for later use.

Girls are at particular risk for stress because of the hormone progesterone. Children and postmenopausal women have relatively low levels of progesterone, but with the onset of puberty, progesterone levels increase in girls. Progesterone allows cortisol to run rampant. Once the teenage girl becomes stressed, it takes a long time to de-stress.

Turing’s secret had been exposed, and his sexuality was now public knowledge. The British Government withdrew his security clearance. He was forbidden to work on research projects relating to the development of the computer. He was forced to consult a psychiatrist and had to undergo hormone treatment, which made him impotent and obese. Over the next two years he became severely depressed, and on June 7, 1954, he went to his bedroom, carrying with him a jar of cyanide solution and an apple. Twenty years earlier he had chanted the rhyme of the Wicked Witch: “Dip the apple in the brew, Let the sleeping death seep through.” Now he was ready to obey her incantation. He dipped the apple in the cyanide and took several bites. At the age of just forty-two, one of the true geniuses of cryptanalysis committed suicide.

The lighter portions are the periods where your body has excess energy because you ate. The darker portions are the periods when the body has no energy left from food and thus has to burn fat to stay alive. As you can see, we burn quite a bit of fat when we sleep. If the lighter and darker portions balance out every day—if you store just as much fat as you burn—your weight stays the same. If you store more fat than you burn (by overeating), you get fatter. And if you burn more fat than you store, you get leaner. This is the fundamental mechanism underlying fat storage and fat loss, and it takes precedence over anything related to insulin or any other hormones or physiological functions. Simply put, you can’t get fatter unless you feed your

Besides having been identified recently as the single most important factor in what men find sexy in women, the list of how correct posture influences internal organs and systems, and also mood and general energy, is very long indeed. Your internal environment depends on the efficiency of the flow of elements within it. Obviously, this includes oxygen, blood, hormones and nutrients, but also all interaction between nerves and the brain. The spine, which is your foundation and support, has a natural position that guarantees the efficiency of movement and interaction of the related elements. Your internal organs are all right alongside the spine and depend on its correct position to function well. Any prolonged restriction or deviation from this natural position will result in some, at least partial, dysfunction. Over a long time, the results can be devastating.

Sleep can factor into one’s weight. Leptin is a hormone produced in the fat cells that signals the brain that the body has had enough to eat. It is produced in relation to how much you sleep. Not getting enough sleep can drive down leptin levels. This drop in leptin level in turn can lead to overeating because the brain is not receiving the “full” signal. Another hormone that is affected by sleep is ghrelin. Ghrelin is a hormone produced in the gastrointestinal tract that stimulates appetite. Once food enters the stomach, the body halts ghrelin production. A lack of sleep can cause ghrelin levels to rise, leading to an increased sense of hunger. In essence, a chronic lack of sleep can cause a person to want to eat more and feel less satisfied than they would otherwise be when well-rested.

If you’re like most people, a string of nerve-racking incidents keeps you in fight-or-flight response—and out of homeostasis—a large part of the time. Maybe the car cutting you off is the only actual life-threatening situation you encounter all day, but the traffic on the way to work, the pressure of preparing for a big presentation, the argument you had with your spouse, the credit-card bill that came in the mail, the crashing of your computer hard drive, and the new gray hair you noticed in the mirror keep the stress hormones circulating in your body on a near-constant basis. Between remembering stressful experiences from the past and anticipating stressful situations coming up in your future, all these repetitive short-term stresses blur together into long-term stress. Welcome to the 21st-century version of living in survival mode. In fight-or-flight mode, life-sustaining energy is mobilized so that the body can either run or fight. But when there isn’t a return to homeostasis (because you keep perceiving a threat), vital energy is lost in the system. You have less energy in your internal environment for cell growth and repair, long-term building projects on a cellular level, and healing when that energy is being channeled elsewhere. The cells shut down, they no longer communicate with one another, and they become “selfish.” It’s not time for routine maintenance (let alone for making improvements); it’s time for defense. It’s every cell for itself, so the collective community of cells working together becomes fractured. The immune and endocrine systems (among others) become weakened as genes in those related cells are compromised when informational signals from outside the cells are turned off. It’s like living in a country where 98 percent of the resources go toward defense, and nothing is left for schools, libraries, road building and repair, communication systems, growing of food, and so on. Roads develop potholes that aren’t fixed. Schools suffer budget cuts, so students wind up learning less. Social welfare programs that took care of the poor and the elderly have to close down. And there’s not enough food to feed the masses. Not surprisingly, then, long-term stress has been linked to anxiety, depression, digestive problems, memory loss, insomnia, hypertension, heart disease, strokes, cancer, ulcers, rheumatoid arthritis, colds, flu, aging acceleration, allergies, body pain, chronic fatigue, infertility, impotence, asthma, hormonal issues, skin rashes, hair loss, muscle spasms, and diabetes, to name just a few conditions (all of which, by the way, are the result of epigenetic changes). No organism in nature is designed to withstand the effects of long-term stress.

The type of food you consume directly affects your metabolism and insulin response. Food is composed of three macronutrients: protein, carbohydrate, and fat, and each of these macronutrients affects your metabolism in a different way. One gram of protein or carbohydrate provides four calories, while one gram of fat contains nine calories. A calorie is the base unit of heat measurement related to metabolic rate. It measures how much energy a particular food provides to the body. Of course, if you do eat more calories than your body requires, it doesn’t matter whether those calories come from protein, carbohydrates, or fat—the extra fuel will be stored in the body as fat. Eating too few calories can be equally problematic. When you do not eat enough food, your body’s endocrine, immunological, and nervous systems begin to malfunction. The result is often hormonal imbalances, thyroid problems, and insulin resistance. When you are in a state of extreme caloric restriction, your body does everything possible to return to a state of homeostasis, or equilibrium—including slowing down your metabolic rate. A slow metabolism affects your energy levels, your digestive and hormonal health, and your ability to lose weight. In my case, severely restricting my calories increased my adrenal

THE IMPACT OF DOING TOO MUCH A study done at the University of London found that constant emailing and text-messaging reduces mental capability by an average of ten points on an IQ test. It was five points for women, and fifteen points for men. This effect is similar to missing a night’s sleep. For men, it’s around three times more than the effect of smoking cannabis. While this fact might make an interesting dinner party topic, it’s really not that amusing that one of the most common “productivity tools” can make one as dumb as a stoner. (Apologies to technology manufacturers: there are good ways to use this technology, specifically being able to “switch off” for hours at a time.) “Always on” may not be the most productive way to work. One of the reasons for this will become clearer in the chapter on staying cool under pressure; however, in summary, the brain is being forced to be on “alert” far too much. This increases what is known as your allostatic load, which is a reading of stress hormones and other factors relating to a sense of threat.

Blood pressure: Take and compare two blood pressure readings—one while lying down and one while standing. Lie down for five minutes before taking the first reading. Then stand up and immediately take your blood pressure again. If your blood pressure is lower after standing, you probably have reduced adrenal gland function—more specifically inadequate aldosterone, which is an adrenal hormone that regulates your blood pressure. The degree to which blood pressure drops while standing is often proportionate to the degree of aldosterone-related adrenal issues. If your adrenal function is normal, your body will elevate your blood pressure when you stand up in order to push blood to your brain. If adrenal function is not normal, your blood pressure does not elevate, and this is why overtrained athletes tend to get dizzy more often.

Reduced Disease Risk Factors: Ditching grains, sugars, other simple carbs, and processed foods, especially “bad fats” (trans and partially-hydrogenated), will reduce your production of hormone-like messengers that instruct genes to make harmful pro-inflammatory protein agents. These agents increase your risk for arthritis, diabetes, cancer, heart disease, and many other inflammation-related health problems.

Someone starts out sedentary, overweight, and somewhat insulin resistant. They set out to improve their health and lose some weight by following a low-carb diet. It works great. They lose weight, their insulin sensitivity improves, and their energy is through the roof. They start exercising, which helps them lose some more weight, as well as build some lean muscle mass. Now they are really into it, and the frequency and intensity of their training increases. This individual is now at a healthy weight (or relatively lean), is exercising regularly, and has better insulin sensitivity. They are a completely different person, metabolically speaking, then when they started. But the problem is they are no longer properly fueling their body and recovering from their intense training sessions (which were once non-existent). They are starting to feel tired and fatigued in the gym, are always in a bad mood, are holding on to stubborn body fat, can’t sleep at night, get sick all of the time, and are maybe having some sexual performance and hormonal issues. Their diet no longer matches their new activity levels and current metabolic condition, because those have completely changed over time. If this person objectively looked at their situation and progress and listened to their own body and biofeedback, they would consider some dietary adjustments. A moderate-to-higher carb intake might be a better fit. But some people will cling to a diet that initially gave them good results, and got them from Point A to Point B, thinking it will get them from Point B to Point C. I’ve been there myself. Part of it is initial experience, part of it is marketing material, and part of it is pure emotion. It doesn’t always work that way for continued progress.

In the short term, your body has checks and balances to compensate for too much or too little of any hormone; it’s your system’s long-term response that causes persistent symptoms and chronic conditions. As your hormones try to help your body get balanced again, they may instead overcompensate and create other imbalances. This will impact how much estrogen and testosterone, growth hormones, hunger hormones, stress hormones, fat-burning hormones, energy- and libido-related hormones, and sleep hormones it should be making to amend the situation.

The Biology of Animal Stress, prenatal exposure to elevated levels of stress hormones, such as cortisol and adrenaline, can set puppies up to develop abnormal brain chemistries, specifically, an abnormal regulation in the pathway between the hypothalamus in the brain and the adrenal glands (glands that produce stress-related hormones), called the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis abnormalities can lead to anxiety, fear, and even aggression problems as adults.

Estradiol—Estradiol is the strongest estrogen; it helps you think clearly. It is produced in the ovaries and has many protective effects, including maintaining bone density, improving growth hormone production and cardiovascular function, keeping your blood from getting “sticky,” supporting cognitive function and mood, assisting in growth hormone release, and improving your lipids profile. Too much estradiol can be associated with estrogen-related cancers, but deficiencies can lead to osteoporosis, heart disease, dementia, and other diseases of aging. Estradiol keeps you looking and feeling young and vibrant. It also provides antiaging protection for the skin. And it even helps prevent weight gain. Researchers at Yale University have found that estradiol suppresses appetite using the same pathways in the brain as leptin, which is one of the hormones that regulate appetite.

Estriol—Estriol is the weakest of the three estrogens and has a protective role in breast tissue. It is believed to protect vaginal tissue too. Estriol helps to reduce hot flashes in women, protects the urinary tract, and plays a role in retention of bone density. It can help increase “good” HDL and decrease “bad” LDL cholesterol. One compelling study showed that taking estriol can reverse brain lesions in women with multiple sclerosis. Estrogen is particularly needed in women to make serotonin function at its best in the brain. Serotonin is one of the brain’s feel-good hormones. With no estrogen, your mood can change to anxious and depressed. Cognitive functions, such as critical thinking and short-term memory, are also eroded with the loss of estrogen production. Below is a list of symptoms related to low and high estrogen levels:

Alan Turing was another cryptanalyst who did not live long enough to receive any public recognition. Instead of being acclaimed a hero, he was persecuted for his homosexuality. In 1952, while reporting a burglary to the police, he naively revealed that he was having a homosexual relationship. The police felt they had no option but to arrest and charge him with “Gross Indecency contrary to Section 11 of the Criminal Law Amendment Act 1885.” The newspapers reported the subsequent trial and conviction, and Turing was publicly humiliated. Turing’s secret had been exposed, and his sexuality was now public knowledge. The British Government withdrew his security clearance. He was forbidden to work on research projects relating to the development of the computer. He was forced to consult a psychiatrist and had to undergo hormone treatment, which made him impotent and obese. Over the next two years he became severely depressed, and on June 7, 1954, he went to his bedroom, carrying with him a jar of cyanide solution and an apple. Twenty years earlier he had chanted the rhyme of the Wicked Witch: “Dip the apple in the brew, Let the sleeping death seep through.” Now he was ready to obey her incantation. He dipped the apple in the cyanide and took several bites. At the age of just forty-two, one of the true geniuses of cryptanalysis committed suicide.

It’s Thanksgiving, and you’ve eaten with porcine abandon. Your bloodstream is teeming with amino acids, fatty acids, glucose. It’s far more than you need to power you over to the couch in a postprandial daze. What does your body do with the excess? This is crucial to understand because, basically, the process gets reversed when you’re later sprinting for your life. To answer this question, it’s time we talked finances, the works—savings accounts, change for a dollar, stocks and bonds, negative amortization of interest rates, shaking coins out of piggy banks—because the process of transporting energy through the body bears some striking similarities to the movement of money. It is rare today for the grotesquely wealthy to walk around with their fortunes in their pockets, or to hoard their wealth as cash stuffed inside mattresses. Instead, surplus wealth is stored elsewhere, in forms more complex than cash: mutual funds, tax-free government bonds, Swiss bank accounts. In the same way, surplus energy is not kept in the body’s form of cash—circulating amino acids, glucose, and fatty acids—but stored in more complex forms. Enzymes in fat cells can combine fatty acids and glycerol to form triglycerides (table). Accumulate enough of these in the fat cells and you grow plump. Meanwhile, your cells can stick series of glucose molecules together. These long chains, sometimes thousands of glucose molecules long, are called glycogen. Most glycogen formation occurs in your muscles and liver. Similarly, enzymes in cells throughout the body can combine long strings of amino acids, forming them into proteins. The hormone that stimulates the transport and storage of these building blocks into target cells is insulin. Insulin is this optimistic hormone that plans for your metabolic future. Eat

Thyroid tissue disorder related to thyroid peroxidase (TPO) autoimmune response:366 TPO is the enzyme in the thyroid responsible for the production of thyroid hormones and is a common site for autoimmune attacks. A positive TPO antibody test suggests Hashimoto’s disease. Nutritional support Regulatory T-cell Support • Emulsified vitamin D and liposomal glutathione and superoxide dismutase cream. TH-1 response or TH-2 response •     Nutritional compounds to support the TH-1 response. Key ingredients include astragalus root extract, echinacea purpurea root, licorice root extract, porcine thymus gland, lemon balm, maitake mushroom, and pomegranate. •     Nutritional compounds to support the TH-2 response. Key ingredients include pine bark extract, grape seed extract, green tea extract, resveratrol, and pycnogenol. Please work with a qualified healthcare practitioner to safely and correctly use these nutrients in the right amounts.

Excessive body acidity is regarded to become the first step in premature aging, vision and memory problems, wrinkling, age spots, hormone system failure, and a slew of other age-related issues. In addition, body acidity is linked to practically most diseases.

people are not trustworthy, that when stressed he cannot really emotionally stay connected to them, and that he is unworthy of being loved. This way of seeing the world is typical of insecure attachments and these unconscious emotional biases will guide overt behavior, especially under relational stress. What is more, the infant of a misattuned mother will frequently be presented with an aggressive expression on his mother’s face, implying he is a threat, or with an expression of fear-terror, implying that he is the source of alarm. Images of his mother’s aggressive and/or fearful face, and the resultant chaotic alterations in her bodily state, are internalized, meaning they are imprinted in his developing right brain limbic circuits as an implicit memory, below levels of consciousness. Although out of awareness, they can plague him and his relationships for his entire life unless he finds a way to bring them into conscious awareness and work with them. Furthermore, when the caregiver is attuned in her early interactions, her more mature nervous system is regulating the infant’s neurochemistry and homeostasis. This, in turn, has a profound influence on the structural organization of the developing brain. Conversely emotional trauma will negatively impact the parts of the brain which are developing at the time of trauma. For example, if high levels of stress hormones are circulating in a pregnant mother, it up-regulates the fetus’ developing stress response – making the child, and future adult hypersensitive to stress. Relational trauma that occurs around the time of birth has a negative impact on both the developing micro-architecture of the amygdala itself, and the amygdala’s connection to the HPA axis, as well as to other parts of the limbic system. Thus high levels of early unrepaired interpersonal stress have a profoundly harmful effect on the ability to form social bonds, and on temperament. Suffering unrepaired and frequent emotional stress after about ten months interferes with the experience-dependent maturation of the highest level regulatory systems in the right orbifrontal cortex. This opens the door

Cortisol and related glucocorticoid hormones both weaken existing synaptic connections in the hippocampus and inhibit the formation of new ones.

That attachment styles can vary based on type—for example, friendship or a romantic relationship. 2. That how a person behaves in one relationship—for example, with one specific friend—can spread to how they behave in other relationships of that same type—such as with other friends. This concept is important because it truly demonstrates the ability of the subconscious to store and replay beliefs based on repetition and emotion. Now that you understand the fluidity of attachment styles and why they lie along a spectrum, you can begin to discover your dominant attachment style in different areas of your life. Consider how you act and feel in your relationships, whether they are romantic, platonic, or familial. Examine the ratio of activating to deactivating strategies in your thoughts and behaviors. Recall that activating strategies are decisions that are made based on prior information and experiences. Deactivating strategies are actions that drive self-reliance and deny attachment needs altogether, pushing others away. If you have relatively more activating strategies, you may have a greater fear of abandonment and be on the Anxious side of the spectrum. More deactivating strategies may indicate a subconscious belief around complete autonomy, placing you more on the Dismissive-Avoidant side of the attachment scale. Keep in mind that this tool should be used in romantic relationships after the honeymoon phase is over, a phase that occurs during the first two years of the relationship. During the honeymoon phase, your brain has higher levels of dopamine in the caudate nucleus and ventral tegmental regions, according to Scientific American. These areas of the brain are responsible for, respectively, learning and memory and emotional processing. Consequently, your attachment style may be unclear to you in the early phases of your romantic relationship since your emotions, memory, and hormone regulation are atypical. Our experiences can also dramatically alter our attachment style. For example, if Sophie were to partake in certain forms of therapy and practices such as recurrent meditation, she may be able to better understand and re-equilibrate her subconscious beliefs. According to Science Daily, since meditation induces theta brain waves and activates areas of the frontal lobe associated with emotional regulation, Sophie could eventually bring herself into a more Secure attachment space without the help of a Secure partner. However, although it is common to express different attachment styles in different areas of life, the type of attachment you have in relationships ultimately tends to be the attachment style that you associate with the type of relationship. For example, you can be Dismissive-Avoidant in familial relationships because you experienced emotional neglect from parental figures, but you could also be Fearful-Avoidant in romantic relationships due to domestic abuse that has occurred. This illustrates that major events such as betrayal, loss, or abuse can alter our attachment style in different chapters of life, but that ultimately attachment styles are fluid and often dependent on the kind of relationships we are in. We tend to have a primary attachment style, most associated with how we show up in romantic relationships, that plays a large role in our personality structure. This essentially dictates how we give and receive love and what our subconscious expectations are of others.

10 Common Reasons for IVF Failure  In-vitro fertilization or IVF provides a means towards parenthood to couples struggling with natural pregnancy. Although IVF is a successful, safe, and effective technique some couples may struggle with multiple IVF failures. According to Dr Vandana Narula, MBBS, MD (Obstetrics & Gynaecology), a lot of factors contribute to the success or failure of IVF. The best infertility specialist in sector 43 Chandigarh advises you to not lose hope and discuss the opportunities with your doctor. 10 Common Reasons for IVF Failure The infertility & IVF specialist in Mohali gives the following common reasons for IVF failure: 1. Poor Sperm Quality The quality of sperm determines the quality of the embryo. Men with certain medical conditions including azoospermia or diabetes may procedure poor quality and quantity of sperm. This can either hamper the development of the embryo or lead to an abnormal embryo. 2. Low Anti-Mullerian Hormone (AMH) Values AMH is a hormone secreted by cells in the egg. A good level of AMH in the woman’s blood indicates good ovarian reserve. Women with low AMH values may procedure unhealthy eggs that may not be implanted. 3. Implantation Failure Implantation failure is one of the common causes of IVF failures. It is usually caused by: A non-receptive uterus lining, thin lining, or lining affected by genital tuberculosis. Prevailing immunological conditions make the uterine environment hostile for the embryos. The endometrium has an inbuilt mechanism to reject poor-quality embryos. 4. Poor Quality of Eggs and Embryos The quality of eggs plays a significant role in IVF failure. The quality of eggs is directly related to the age of a woman and her health. The human egg consists of 23 chromosomes. If any of these chromosomes are missing or arranged incorrectly, they can produce abnormal embryos. A woman’s age also plays a key role in the egg quality. With advancing age, the eggs become less healthy and are prone to genetic abnormalities. This can make it difficult for them to be fertilized by sperm and lead to abnormal embryos.

10 Things You Should Always Discuss with Your Gynecologist – Motherhood Chaitanya Hospital Your gynecologist is your partner in women’s health, and open communication is key to receiving the best care. From reproductive health to general well-being, here are 10 crucial topics you should always discuss with your gynecologist. If you’re in Chandigarh, consider reaching out to the Best Female Gynecologist in Chandigarh through Motherhood Chaitanya for expert care. 1. Menstrual Irregularities Don’t dismiss irregular periods as a minor issue. They could be indicative of underlying conditions like polycystic ovary syndrome (PCOS), thyroid disorders, or hormonal imbalances. 2. Contraception Discuss your contraception options to find the one that best suits your needs and lifestyle. Your gynecologist can provide guidance on various birth control methods, from pills to intrauterine devices (IUDs). 3. Pregnancy Planning If you’re planning to start a family, consult your gynecologist for preconception advice. This can help you prepare your body and address any potential risks or concerns. 4. Sexual Health Openly discuss any concerns related to sexual health, including pain during intercourse, sexually transmitted infections (STIs), or changes in sexual desire. Your gynecologist can provide guidance and offer solutions. 5. Menopause and Perimenopause If you’re in your 40s or approaching menopause, discuss perimenopausal symptoms like hot flashes, mood swings, and changes in menstrual patterns. Your gynecologist can recommend treatments to manage these changes. 6. Family History Share your family’s medical history, especially if there are instances of gynecological conditions, such as ovarian or breast cancer. This information is vital for early detection and prevention. 7. Breast Health Talk to your gynecologist about breast health, including breast self-exams and recommended mammograms. Regular breast checks are essential for early detection of breast cancer. 8. Pelvic Pain Don’t ignore persistent pelvic pain. It can signal a range of issues, including endometriosis, fibroids, or ovarian cysts. Early diagnosis and treatment are crucial. 9. Urinary Issues Frequent urination, urinary incontinence, or pain during urination should be discussed. These symptoms can be linked to urinary tract infections or pelvic floor disorders. 10. Mental Health Your gynecologist is there to address your overall well-being. If you’re experiencing mood swings, anxiety, or depression, it’s important to discuss these mental health concerns. Your gynecologist can offer guidance or refer you to specialists if needed. In conclusion, your gynecologist is your go-to resource for women’s health, addressing a wide spectrum of issues. Open and honest communication is essential to ensure you receive the best care and support. If you’re in Chandigarh, consider consulting the Best Gynecologist Obstetricians in Chandigarh through Motherhood Chaitanya for expert guidance. Your health is a priority, and discussing these important topics with your gynecologist is a proactive step toward a healthier, happier you

From about four months of age until puberty, boys and girls don’t differ in their levels of testosterone, estrogen, and other sex-related hormones. So please correct parents who blame their seven-year-old son’s crazy behavior on testosterone. Until puberty, his testosterone level doesn’t differ from that of girls.

simply by doing one of three poses related to power for only two minutes a day, you can create a 20 per cent increase in the confidence hormone, testosterone, and a 25 per cent decrease in the stress hormone, cortisol.7 The so-called ‘power poses’ are a quick and easy way to feel more powerful, says the report.

Norepinephrine: The Wake-Up Neurotransmitter One of norepinephrine’s effects on the brain is to sharpen attention. As we saw earlier, norepinephrine (aka noradrenaline) can function as both a neurotransmitter and a hormone. When we perceive stress and activate the fight-or-flight response, the brain produces bursts of norepinephrine, triggering anxiety. But sustained and moderate secretion can also produce a beneficial result in the form of heightened attention, even euphoria, and meditation has been shown to produce a rise in norepinephrine in the brain. A modest dose of norepinephrine is also associated with reduced beta brain waves. 5.11. Norepinephrine: your wake-up molecule. Notice the paradox here. Norepinephrine is associated with both anxiety and attentiveness. How do you get enough to be alert, but not so much you’re stressed? Surrender is the key. Steven Kotler, co-author of Stealing Fire, says that stress neurochemicals like norepinephrine actually prime the brain for flow states. At first, the meditator is frustrated by Monkey Mind. But if she surrenders, despite the perpetual self-chatter of the DMN, she enters the next phase of flow, which is focus. She has hacked her biology, using the negative experience of mind wandering as a springboard to flow. Norepinephrine’s molecular structure is similar to its cousin, epinephrine. While epinephrine works on a number of sites in the body, norepinephrine works exclusively on the arteries. When both dopamine and norepinephrine are present in the brain at the same time, they amplify focus. Attention becomes sharp, while perception is enhanced. Staying alert is a key function of the brain’s attention circuit, which keeps you focused on the object of your meditation and counteracts the wandering mind. It also stops you from becoming drowsy, an occupational hazard for meditators. That’s because pleasure neurotransmitters such as serotonin and melatonin (for which serotonin is the precursor) can put you to sleep if not balanced by alertness-producing norepinephrine. Again, the ratios are the key. Oxytocin: The Hug Drug 5.12. Oxytocin: your cuddle molecule. Oxytocin is produced by the hypothalamus, part of the brain’s limbic system. When activated, neurons in the hypothalamus stimulate the pituitary gland to release oxytocin into the bloodstream. So even though oxytocin is produced in the brain, it has effects on the body as well, giving it the status of a hormone. It is one of a group of small protein molecules called neuropeptides. A closely related neuropeptide is vasopressin. All mammals produce some variant of these neuropeptides. Oxytocin promotes bonding between humans. It is responsible for maternal feelings and physically prepares the female body for childbirth and nursing. It is generated through physical touch but also by emotional intimacy. Oxytocin also facilitates generosity and trust within a group. Oxytocin is the hormone associated with the long slow waves of delta. A researcher hooking subjects up to an EEG found that touch stimulated greater amounts of delta, with certain regions of the skin being more sensitive. The biggest effect was produced by tapping the cheek, as we do in EFT. It produced an 800% spike in delta.

It’s not just in humans that we find this—non-human primates that live in social groups display higher rates of disease and illness, and greater levels of stress-related hormones, when they’re lower in the hierarchy.

Music to heal: To heal problems related to children, honour, getting a position in life, relationships with father and government - Raag Tanpura, Raag Shadbhinna, Raag Darbari To heal mental peace, relations with mother, happiness, calmness, family atmosphere, emotional trauma and pain - Raag Sudh, Raag Komal, Raag Yaman, Hansdhawani To heal property realated issues, blood related problems, violence and accidents - Bhairvai, Asavi, Thodi To heal education related troubles, fights with siblings, throid and hormonal imbalance, communication, business, friends - Gandharva, Kalyan, Poorvi To heal relationship issues, money related troubles - Nat Bhairav, Brindabani Sarang Lack of happiness, motivation, purpose, intagible happiness missing - Raag Shudha Profession problems, long term diseases, chronic troubles - Jaunpuri, Kirwani, Neelambri

Plasticity of neuroendocrine-thymus interactions during aging N.Fabris12E.Mocchegiani2M.Provinciali2 Abstract Thymic regrowth and reactivation of thymic endocrine activity may be achieved even in old animals by different endocrinological or nutritional manipulations such as, (a) intrathymic transplantation of pineal gland or treatment with melatonin, (b) implantation of a growth hormone (GH) secreting tumor cell line or treatment with exogenous GH, (c) castration or treatment with exogenous luteinizing hormone-releasing hormone (LH-RH), (d) treatment with exogenous thyroxine or triiodothyronine, and (e) nutritional interventions such as arginine or zinc supplementation. These data strongly suggest that thymic involution is a phenomenon secondary to age-related alterations in neuroendocrine-thymus interactions and that it is the disruption of such interactions in old age that is responsible for age-associated dysfunction. Melatonin or other pineal factors may act through specific receptors, but experimental evidence is still lacking. The role of zinc, whose turnover is usually reduced in old age, is diverse. The effects range from the reactivation of zinc-dependent enzymes, required for both cell proliferation and apoptosis, to the reactivation of thymulin, a zinc-dependent thymic hormone. The role of zinc may even be more crucial. According to recent preliminary data obtained both in animal and human studies, it appears that the above reported endocrinological manipulations capable of restoring thymic activity in old age, may act also by normalizing the altered zinc pool.

The study was done in a relatively small town in Kyoto named Kyotango.  What makes this town special and a very good place to conduct the study was the fact that its population of people above 100 years old was the highest in Japan - 3 times more than the average for any town in the country.  The program - Takeshi no katei no igaku - specifically wanted to find out what these very old - but very joyful - bunch of people in Kyotango had in common when it comes to living their daily lives.  The program followed 7 people who were already in their late 90s and early 100s from sunrise to sunset.  The program also subjected them to health checkups such as blood tests, among others.  One of the interesting findings of the study was that all of the 7 subjects had very high levels of DHEA, which is a steroid hormone produced by the body's adrenal glands.  DHEA has a solid reputation of being a miracle hormone that's highly associated with longevity.  And as the study continued following the 7 super senior citizens, they discovered another commonality:  they all did things that they really enjoyed.  Each of them had different hobbies they passionately practiced every day such as painting, fishing and making traditional Japanese masks, among others. Given these findings, is it possible then that doing something you really love to do, something you're very passionate about, is the key to higher levels of DHEA and, therefore, a much longer life?  The science on this relationship hasn't been established yet, but the program concluded that regularly doing something that you're very interested in, passionate about, and focused on can give you a long-lasting and deep sense of personal satisfaction in life, which in turn can help elevate your DHEA levels.  And when such levels are very high, a long and joyful life isn't far behind.  And guess what, the program repeatedly made mention of Ikigai in discussing this concept of conclusion.

Our study clearly showed that when traumatized people are presented with images, sounds, or thoughts related to their particular experience, the amygdala reacts with alarm—even, as in Marsha’s case, thirteen years after the event. Activation of this fear center triggers the cascade of stress hormones and nerve impulses that drive up blood pressure, heart rate, and oxygen intake—preparing the body for fight or flight.1 The monitors attached to Marsha’s arms recorded this physiological state of frantic arousal, even though she never totally lost track of the fact that she was resting quietly in the scanner.

PCOS is not one disease. Instead, it’s a group of symptoms related to androgen excess. That’s why it’s described as a heterogeneous endocrine disorder.

There’s also some indication that replacing carbohydrate with plant rather than animal foods has special health benefits. Among approximately eighty thousand women in the Nurses’ Health Study consuming lower-carbohydrate diets, high consumption of vegetable protein and fat was associated with a 30 percent lower risk for heart disease over twenty years, whereas high consumption of animal protein and fat appear to provide no such protection. One explanation for this finding is that the relative amounts of amino acids in animal protein stimulate more insulin and less glucagon release than those in plant protein – a hormone combination that has detrimental effects on serum cholesterol and fat-cell metabolism. Other possible downsides of a modern, animal-based diet include a less healthful profile of dietary fats, excessive iron absorption (especially for men), and chronic exposure to hormones, preservatives, and environmental pollutants.

of stimulating reward pathways in the brain, such as drugs, sex, aggression, and intimidating others, could become relatively more attractive and less constrained by concern about violating trusting relationships. The ability to modify behavior based on negative experiences may be impaired.30 Hard-core drug addicts, whose lives invariably began under conditions of severe stress, are all too readily triggered into a stress reaction. Not only does the stress response easily overwhelm the addict’s already-challenged capacity for rational thought when emotionally aroused, but the hormones of stress also “cross-sensitize” with addictive substances. The more one is present, the more the other is craved. Addiction is a deeply ingrained response to stress, an attempt to cope with it through self-soothing. Maladaptive in the long term, it is highly effective in the short term. Predictably, stress is a major cause of continued drug dependence. It increases opiate craving and use, enhances the reward efficacy of drugs, and provokes relapse to drug seeking and drug taking.31 “Exposure to stress is the most powerful and reliable experimental manipulation used to induce reinstatement of alcohol or drug use,” one team of researchers reports.32 “Stressful experiences,” another research group points out, “increase the vulnerability of the individual to either develop drug self-administration or relapse.”33

No one meat for us to be miserable. We actually make "happy hormones" in our brains. These are designed to make us feel good. But there are many things that can turn off these hormones, just as there are many things that can turn them on. And the amount of happy hormones you make in the brain is directly related to the type of diet you ingest. The difficulty is that we are all different in our biochemistry, and hence, also unique in what foods make us the happiest. In other words, many people feel really mellow and content on a high carbohydrate (vegan or alkaline) diet. Many use this to optimize their athletic performance. While others are carnivores, not vegans, and feel best with meat (acid diet) at every meal. They get weak and lower their zip if they lower their meat content.

In 2003, epidemiologists from the Centers for Disease Control, led by Eugenia Calle, published an analysis in The New England Journal of Medicine reporting that cancer mortality in the United States was clearly associated with obesity and overweight. The heaviest men and women, they reported, were 50 and 60 percent more likely, respectively, to die from cancer than the lean. This increased risk of death held true for a host of common cancers—esophageal, colorectal, liver, gallbladder, pancreatic, and kidney cancers, as well as, in women, cancers of the breast, uterus, cervix, and ovary. In 2004, the CDC followed up with an analysis linking cancer to diabetes, particularly pancreatic, colorectal, liver, bladder, and breast cancers. Cancer researchers trying to make sense of this association would later say that something about cancer seems to thrive on the metabolic environment of the obese and the diabetic. One conspicuous clue as to what that something might be was that the same association was seen with people who weren’t obese and diabetic (or at least not yet) but suffered only from metabolic syndrome and thus were insulin-resistant. The higher their levels of circulating insulin, and that of a related hormone known as insulin-like growth factor, the greater the likelihood that they would get cancer.

Estrogen metabolism is the healthy removal or detoxification of estrogen from your body. It’s a two-step process. First, your liver inactivates estrogen by attaching a little molecule or “handle,” which is called conjugation. To do that effectively, your liver needs a good supply of nutrients such as folate, vitamin B6, vitamin B12, zinc, selenium, magnesium, and protein. Your liver also needs to be relatively free from the toxic effects of alcohol or endocrine disrupting chemicals. Even one drink per day can increase your blood level of estrogen.

PCOS is a common diagnosis that affects up to 10 percent of women. It’s best defined as a group of symptoms related to anovulation (lack of ovulation) and a high level of androgens or male hormones. The main symptom of PCOS is irregular periods, specifically late periods or too many days of bleeding. Irregular periods are typical of anovulatory cycles.

Key to Ratings: Probably OK = (X) Not ideal = (XX) Pretty bad = (XXX) Definitely dangerous = (XXXX) ~ ~ ~ How bad is it to drink water out of a bottle that you left in the car for weeks? (X) First, know that despite scary e-mail forwards from nervous relatives, you needn’t worry about disposable plastic water bottles leaching cancer-causing chemicals into the liquid, according to the American Cancer Society. Commercial water bottles often don’t contain concerning hormone-disrupting chemicals like bisphenol A ( BPA) or phthalates either. But any used bottle can harbor germs from saliva backwash, says Charles Gerba, a microbiologist at the University of Arizona and coauthor of The Germ Freak’s Guide to Outwitting Colds and Flu. Surprisingly, “that’s not really a problem as long as you don’t share the bottle with other people,” he says, since your immune system has already dealt with whatever cold, flu, or other germs may be in your mouth. One exception: sports bottles that you’ve used your thumb or fingers to press shut. Bacteria such as E. coli or Staphylococcus on your hands can contaminate the nozzle when you press it down and then flourish in the

And then there are the eternal questions of love and sex. Can there be friendship between men and women as long as the hormones rage and rule? How is sex related to love -- and love to sex? Are we truly pigeonholed in our sexuality -- or does society alone insist on this? What is 'straight'? What is 'gay'? What is 'bi'? And does any of it matter deep in one's soul? Shouldn't we get rid of these labels in an attempt to be really open to ourselves and to each other?

Unbalanced and low levels of hormones have been associated with numerous chronic problems and age-related conditions. Along with many other actions, hormones are chemical messengers; they signal the cells to become younger or older, to slow or increase multiplication, to be immunologically responsive or lazy.

Chakras are energy centers where the body's life energy is concentrated. The concept of chakra is found in the Hindu tradition in India & some disciplines of Buddhism. Of the seven major chakras, six are located along the spinal cord & one is located at the crown of the head. The chakras are closely related to the endocrine system,which secretes hormones, and they are known to influence each and every part of the human body through the autonomic nervous system. They are highly attuned sensors that respond to the state of your physical, mental & spiritual health.

Menopause has been linked to the following microbiome changes: REDUCED MICROBIAL DIVERSITY: Menopause and lower estrogen levels have been associated with a decrease in the diversity of the gut microbiome. This decrease can disrupt the delicate balance within the microbiota, potentially leading to health complications. SHIFT TOWARD MALE-LIKE COMPOSITION: Research suggests that menopause may alter the gut microbiome composition, shifting it to be more like the male microbiome. While we don’t know yet how this may correlate to changes in health, menopause-related microbiome alterations have been linked to adverse cardiometabolic profiles, which may include high blood sugar, high cholesterol, and increased waist circumference. ESTROBOLOME POTENTIAL: A new area of research is related to the estrobolome, which is a collection of enzyme-producing genes found in the gut microbiome that allow your gut bacteria to metabolize estrogen. Interestingly, the actions of the estrobolome allow for inactive estrogen to become active again and re-enter the bloodstream. During menopause, there may be a reduction in estrobolome potential, which could affect estrogen metabolism and hormone-related health. Researchers are exploring the potential role of the estrobolome as it relates to estrogen-responsive cancers, and I suspect we’ll be hearing a lot more about it in the future. INCREASED GUT BARRIER PERMEABILITY: The decline in estrogen and progesterone levels during menopause may lead to increased permeability of the gut barrier. Greater permeability can allow bacteria and their by-products to cross into the bloodstream and potentially trigger inflammation

A cascade of stress-related hormones floods the body in response to the sustained exertion. Blood tests after ultras have shown elevated cardiac enzymes, renal injury, and very high levels of the stress hormone cortisol, the proinflammatory compound interleukin-6, and creatine kinase, a toxic byproduct of muscle breakdown. That’s a lot for the immune system to handle. Approximately one in four runners at the Western States gets a cold after the race, and this is in the height of summer! Most