Hodgkin's Lymphoma Quotes

I’M DYING … I’m dying … dying … I have Hodgkin lymphoma. It’s advanced. And it’s terminal … I have a matter of months left to live, Rune. There’s nothing anyone can do…

Broadly speaking, components of processed foods and animal products, such as saturated fat, trans fat, and cholesterol, were found to be pro-inflammatory, while constituents of whole plant foods, such as fiber and phytonutrients, were strongly anti-inflammatory.938 No surprise, then, that the Standard American Diet rates as pro-inflammatory and has the elevated disease rates to show for it. Higher Dietary Inflammatory Index scores are linked to a higher risk of cardiovascular disease939 and lower kidney,940 lung,941 and liver function.942 Those eating diets rated as more inflammatory also experienced faster cellular aging.943,944 In the elderly, pro-inflammatory diets are associated with impaired memory945 and increased frailty.946 Inflammatory diets are also associated with worse mental health, including higher rates of depression, anxiety, and impaired well-being.947 Additionally, eating more pro-inflammatory foods has been tied to higher prostate cancer risk in men948,949,950 and higher risks of breast cancer,951,952 endometrial cancer,953 ovarian cancer,954 and miscarriages in women. Higher Dietary Inflammatory Index scores are also associated with more risk of esophageal,955 stomach,956 liver,957 pancreatic,958 colorectal,959 kidney,960 and bladder961 cancers, as well as non-Hodgkin lymphoma.962 Overall, eating a more inflammatory diet was associated with 75 percent increased odds of having cancer and 67 percent increased risk of dying from cancer.963 Not surprisingly, those eating more anti-inflammatory diets appear to live longer lives.964,965,966,967 But how does the Dietary Inflammatory Index impact body weight? Obesity and Inflammation:

In general, haematological neoplasms are diseases of elderly patients, the exceptions being acute lymphoblastic leukaemia which predominantly affects children, and Hodgkin lymphoma which affects people aged 20–40 years.

Neutrophils Neutrophilia • Infection: bacterial, fungal • Trauma: surgery, burns • Infarction: myocardial infarct, pulmonary embolus, sickle-cell crisis • Inflammation: gout, rheumatoid arthritis, ulcerative colitis, Crohn’s disease • Malignancy: solid tumours, Hodgkin lymphoma • Myeloproliferative disease: polycythaemia, chronic myeloid leukaemia • Physiological: exercise, pregnancy Neutropenia • Infection: viral, bacterial (e.g. Salmonella), protozoal (e.g. malaria) • Drugs: see Box 24.11 • Autoimmune: connective tissue disease • Alcohol • Bone marrow infiltration: leukaemia, myelodysplasia • Congenital: Kostmann’s syndrome Eosinophils Eosinophilia • Allergy: hay fever, asthma, eczema • Infection: parasitic • Drug hypersensitivity: e.g. gold, sulphonamides • Skin disease • Connective tissue disease: polyarteritis nodosa • Malignancy: solid tumours, lymphomas • Primary bone marrow disorders: myeloproliferative disorders, hypereosinophilia syndrome (HES), acute myeloid leukaemia Basophils Basophilia • Myeloproliferative disease: polycythaemia, chronic myeloid leukaemia • Inflammation: acute hypersensitivity, ulcerative colitis, Crohn’s disease • Iron deficiency Monocytes Monocytosis • Infection: bacterial (e.g. tuberculosis) • Inflammation: connective tissue disease, ulcerative colitis, Crohn’s disease • Malignancy: solid tumours Lymphocytes Lymphocytosis • Infection: viral, bacterial (e.g. Bordetella pertussis) • Lymphoproliferative disease: chronic lymphocytic leukaemia, lymphoma • Post-splenectomy Lymphopenia • Inflammation: connective tissue disease • Lymphoma • Renal failure • Sarcoidosis • Drugs: corticosteroids, cytotoxics • Congenital: severe combined

In March 2015, the World Health Organization determined that the herbicide glyphosate is “probably carcinogenic to humans.” A more recent study found a 41 percent increase in non-Hodgkin’s lymphoma in those with high exposure to glyphosate.

Hodgkin may have been disappointed by what he thought was only a descriptive study of his disease. But he had underestimated the value of careful observation—by compulsively studying anatomy alone, he had stumbled upon the most critical revelation about this form of lymphoma: Hodgkin’s disease had a peculiar propensity of infiltrating lymph nodes locally one by one. Other cancers could be more unpredictable—more “capricious,” as one oncologist put it. Lung cancer, for instance, might start as a spicular nodule in the lung, then unmoor itself and ambulate unexpectedly into the brain. Pancreatic cancer was notoriously known to send sprays of malignant cells into faraway sites such as the bones and the liver. But Hodgkin’s—an anatomist’s discovery—was anatomically deferential: it moved, as if with a measured, ordered pace, from one contiguous node to another—from gland to gland and from region to region.

The FDA agreed. On August 30, 2017, after a unanimous vote by an exuberant advisory committee (“potentially paradigm shifting”), the agency gave its green light to June’s modified T cells for ALL—its first approval ever for a cell-based gene transfer therapy. The Novartis brand name is Kymriah, a play on “chimera.” In 2018, the FDA approved it to treat several types of non-Hodgkin’s lymphoma. (It joined Yescarta, a similar product from Kite Pharma.) Based on some promising trials,

growing only crops was not. Worst was growing up on a poultry farm, which was associated with nearly three times the odds of developing blood cancer.53 Exposure to cattle and pigs has also been associated with non-Hodgkin’s lymphoma.54 A 2003 study by University of California researchers revealed that nearly three-quarters of human subjects tested positive for exposure to the bovine leukemia virus, likely through the consumption of meat and dairy products.55 Approximately 85 percent of U.S. dairy herds have tested positive for the virus (and

PATIENT PROFILE: S.R. was diagnosed at age 48 with stage 4 non-Hodgkins B-cell lymphoma. Tumor was the size of a potato and choking off blood to the intestines. Underwent chemo regimen. S.R. used nutrition supplements in spite of oncologist’s hostility to the subject. S.R. was able to work throughout chemo, travelling to trade shows, though he did lose his hair. As of 2005, S.R. is in complete remission and has learned the value of good nutrition, living more joyfully, and faith in God.

For instance, “For men, prolonged exposure to work-related stress has been linked to an increased likelihood of lung, colon, rectal, and stomach cancer and non-Hodgkin lymphoma.”36 Moreover, we are increasingly understanding the mechanisms linking stress to disease.

Stage 4 Hodgkin’s lymphoma, the doctors said. It had come out of nowhere. And it had come fast, and it had come strong, and while your mother was encouraged to start treatment, you could hear the truth in the doctors’ voices that there wasn’t much time left. That was when your father decided to show his true colors. He packed a single suitcase and walked out the front door and never came back.