Helix Quotes

Science is the belief in the ignorance of experts.

There is a moon shaped rictus in the streetlamp's globe where a stone has gone and from this aperture there drifts down through the constant helix of aspiring insects a faint and steady rain of the same forms burnt and lifeless.

[When asked by a student if he believes in any gods] Oh, no. Absolutely not... The biggest advantage to believing in God is you don't have to understand anything, no physics, no biology. I wanted to understand.

Every time you understand something, religion becomes less likely. Only with the discovery of the double helix and the ensuing genetic revolution have we had grounds for thinking that the powers held traditionally to be the exclusive property of the gods might one day be ours. . . .

Why do you like show jumping?" "... Beauty and excitement. The elements of trust, talent, training, love, and danger make show jumping a thrilling and aesthetic experience. It's really the ultimate test of two nervous systems--the kinetic transfer of the rider's muscle to the horse's muscle enables them to clear those jumps. And there's nothing like it--horse and rider forming an arc of beauty, efficiency, and power, like a double helix." "DNA," "Yes, DNA, the code to life.

Patterns cannot be weighed or measured. Patterns must be mapped.

One could not be a successful scientist without realizing that , in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid.

I’m not responsible for what other people think I am able to do; I don’t have to be good because they think I’m going to be good.

Will we turn our backs on science because it is perceived as a threat to God, abandoning all the promise of advancing our understanding of nature and applying that to the alleviation of suffering and the betterment of humankind? Alternatively, will we turn our backs on faith, concluding that science has rendered the spiritual life no longer necessary, and that traditional religious symbols can now be replaced by engravings of the double helix on our alters? Both of these choices are profoundly dangerous. Both deny truth. Both will diminish the nobility of humankind. Both will be devastating to our future. And both are unnecessary. The God of the Bible is also the God of the genome. He can be worshipped in the cathedral or in the laboratory. His creation is majestic, awesome, intricate and beautiful - and it cannot be at war with itself. Only we imperfect humans can start such battles. And only we can end them.

Your love is different from mine. What I mean is, when you close your eyes, for that moment, the center of the universe comes to reside within you. And you become a small figure within that vastness, which spreads without limit behind you, and continues to expand at tremendous speed, to engulf all of my past, even before I was born, and every word I've ever written, and each view I've seen, and all the constellations, and the darkness of outer space that surrounds the small blue ball that is earth. Then, when you open your eyes, all that disappears. I anticipate the next time you are troubled and must close your eyes again. The way we think may be completely different, but you and I are an ancient, archetypal couple, the original man and woman. We are the model for Adam and Eve. For all couples in love, there comes a moment when a man gazes at a woman with the very same kind of realization. It is an infinite helix, the dance of two souls resonating, like the twist of DNA, like the vast universe. Oddly, at that moment, she looked over at me and smiled. As if in response to what I'd been thinking, she said, "That was beautiful. I'll never forget it.

In his mind World War III represents the final self-destruction and imbalance of an asymmetric world, the last suicidal spasm of the dextro-rotatory helix, DNA. The human organism is an atrocity exhibition at which he is an unwilling spectator . . .

In the end, though, science is what matters; scientists not a bit.

Is this all we are? A necklace of chemicals? Where, in the double helix, does the soul lie?

The way we think may be completely different, but you and I are an ancient, archetypal couple, the original man and woman. We are the model for Adam and Eve. For all couples in love, there comes a moment when a man gazes at a woman with the very same kind of realization. It is an infinite helix, the dance of two souls resonating, like the twist of DNA, like the vast universe.

Maybe that’s all life was, this impossibly complicated helix of choice and accident, things you could control and couldn’t. And when the day was done, the only measure of success was how happy you were, how much you loved and were loved.

The currency of evolution is neither hunger nor pain, but rather copies of DNA helixes. Just as the economic success of a company is measured only by the number of dollars in its bank account, not by the happiness of its employees, so the evolutionary success of a species is measured by the number of copies of its DNA.

Eddie saw great things and near misses. Albert Einstein as a child, not quite struck by a run-away milk-wagon as he crossed a street. A teenage boy named Albert Schweitzer getting out of a bathtub and not quite stepping on the cake of soap lying beside the pulled plug. A Nazi Oberleutnant burning a piece of paper with the date and place of the D-Day Invasion written on it. He saw a man who intended to poison the entire water supply of Denver die of a heart attack in a roadside rest-stop on I-80 in Iowa with a bag of McDonald’s French fries on his lap. He saw a terrorist wired up with explosives suddenly turn away from a crowded restaurant in a city that might have been Jerusalem. The terrorist had been transfixed by nothing more than the sky, and the thought that it arced above the just and unjust alike. He saw four men rescue a little boy from a monster whose entire head seemed to consist of a single eye. But more important than any of these was the vast, accretive weight of small things, from planes which hadn’t crashed to men and women who had come to the correct place at the perfect time and thus founded generations. He saw kisses exchanged in doorways and wallets returned and men who had come to a splitting of the way and chosen the right fork. He saw a thousand random meetings that weren’t random, ten thousand right decisions, a hundred thousand right answers, a million acts of unacknowledged kindness. He saw the old people of River Crossing and Roland kneeling in the dust for Aunt Talitha’s blessing; again heard her giving it freely and gladly. Heard her telling him to lay the cross she had given him at the foot of the Dark Tower and speak the name of Talitha Unwin at the far end of the earth. He saw the Tower itself in the burning folds of the rose and for a moment understood its purpose: how it distributed its lines of force to all the worlds that were and held them steady in time’s great helix. For every brick that landed on the ground instead of some little kid’s head, for every tornado that missed the trailer park, for every missile that didn’t fly, for every hand stayed from violence, there was the Tower. And the quiet, singing voice of the rose. The song that promised all might be well, all might be well, that all manner of things might be well.

Nancy According to astronomers, every atom in my body was forged in a star. I am made, they insist, of stardust. I am stardust braided into strands and streamers of information, proteins and DNA, double helixes of stardust. In every cell of my body there is a thread of stardust as long as my arm.

Music allows us to assemble temporal sequences into mental scaffolding that transcends the thinness of time in which we live.

Time Considered as a Helix of Semi-Precious Stones

Worrying about complications before ruling out the possibility that the answer was simple would have been damned foolishness.

Living in new shapes, reshapes our thinking

​Briefly, the Indiana biochemists encouraged me to learn organic chemistry, but after I used a bunsen burner to warm up some benzene, I was relieved from further true chemistry. It was safer to turn out an uneducated Ph.D. than to risk another explosion.

Perpetual novelty is the hallmark of 'cas'.

We shouldn’t abbreviate the truth but rather get a new method of presentation.

It appears, according to the reported facts, that the electric conflict is not restricted to the conducting wire, but that it has a rather extended sphere of activity around it .. the nature of the circular action is such that movements that it produces take place in directions precisely contrary to the two extremities of a given diameter. Furthermore, it seems that the circular movement, combined with the progressive movement in the direction of the length of the conjunctive wire, should form a mode of action which is exerted as a helix around this wire as an axis.

One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid

In my mind, I could sense their roots under the soil, creeping in helical tangles of ever-increasing complexity outward and in all directions—out beyond the perimeter of the Helsingør Wood, out below Yami’s Under City, out along the banks of the river, out to the nearest coast and thereupon out into the sea; the roots crept down further along the continental shelf, downward into the abysses, downward into the ocean floor, burrowing under the corals and under trenches, and then back up again to sprout in the darkened forest on a foreign continent: all the trees of the world now had conjoined roots, for they were now of one conjoined consciousness!

Unfortunately, upsetting the balance of nature just happens to be what our species has been selected to do well- although we hate admit it. Like the Walrus in Lewis Carroll's poem, we shed hypocritical tears over the diminishing supply of oysters, while gulping them down as quickly as ever.

The double-helix has solved all three of the major challenges of genetic physiology using ingenious variations on the same theme. Mirror-image chemicals are used to generate mirror-image chemicals, reflections used to reconstruct the orginal. Pairs used to maintain the fidelity and fixity of information. "Monet is but an eye," Cezanne once said of his friend, "but, God, what an eye." DNA, by the same logic, is but a chemical-but, God, what a chemical.

If we do survive death, then the next world is veiled from us for a purpose. Regardless of our endless conjecture, each of us will make this discovery individually, whether we wish to or not. However, we do know the conditions of the world around us and its inhabitants; we know these in detail. We can only conclude, then, that we are meant to focus on this world in which we live, and not groundless speculation about the next. History shows that an obsession with the afterlife smothers our concern for the living.

Two lavish marble, glass, and steel staircases shaped like DNA helixes flank the open space

in other words then, if a machine is expected to be infallible, it cannot also be intelligent.

Buddhist religion: “To every man is given the key to the gates of heaven; the same key opens the gates of hell.

Our freedom to doubt was born of a struggle against authority in the early days of science.

The two of them were forever tied to each other, twisting and turning both in unison and in opposition. A double helix. Each necessary to the other’s survival.

If we look away from the science and look at the world around us, we find out something rather pitiful: that the environment that we live in is so actively, intensely unscientific.

Clearly, peace is a great force, as is sobriety, as are material power, communication, education, honesty, and the ideals of many dreamers.

Our responsibility is to do what we can, learn what we can, improve the solutions and pass them on. It is our responsibility to leave the men of the future a free hand.

Whenever I look at you, I’m reminded of how beautiful my creations are,

The two of them were forever tied to each other, twisting and turning both in unison and in opposition. A double helix. Each necessary to the other's survival.

Ah, that picture, it will always haunt me,” he says, then pauses and smiles his impish grin. “But she never figured out it was a helix.”1

Mathematics is looking for patterns.

The currency of evolution is neither hunger nor pain, but rather copies of DNA helixes

On the other hand, the sun of Naples might be conducive to learning something about the biochemistry of the embryonic development of marine animals.

FRANCIS CRICK, the Nobel Prize-winning father of modern genetics, was under the influence of LSD when he first deduced thedouble-helix structure of DNA nearly 50 years ago.

you were talking about physics and if that’s what you’re talking about, then to not know mathematics is a severe limitation in understanding the world.

the way I think of what we’re doing is we’re exploring, we’re trying to find out as much as we can about the world.

My interest in science is to simply find out about the world, and the more I find out the better it is, like, to find out.

Babies grow in a helix of hope and fear.

It is remarkable, the lines that connect people. You can strike up a conversation with someone, a stranger even, and discover that you have a friend in common, that your aunts were from the same town, or that his best friend can grease your way into Bhutan. It seems on those occasions that we are all like strands of DNA, spun around each other in a double helix.

Begin morning run,” I said to Max. “Bifrost track.” The virtual gym vanished. Now I was standing on a semitransparent running track, a curved looping ribbon suspended in a starry nebula. Giant ringed planets and multicolored moons were suspended in space all around me. The running track stretched out ahead of me, rising, falling, and occasionally spiraling into a helix.

Shall we do something we’ve never done? Shall we prick and twist and play the braid until it yields us a place downthread, bend the fork of our Shifts into a double helix around our base pair?

So while Pauling struggled with his model, Watson and Crick turned theirs inside out, so the negative phosphorus ions wouldn’t touch. This gave them a sort of twisted ladder—the famed double helix.

We continued dancing as a swift gale wheeled through the hills of Santa Cruz. Xuan leaned down to whisper into my ear, his lips lightly brushing the helix. “Once upon a time there was a boy, and he loved a girl very much. He was sad because he didn’t think the girl noticed him. Until one day the uni- verse intervened and a beautiful comet brought them together after a tragic accident occurred that day. The boy and the girl found comfort and friendship in each other that night. And something new and extraordinary began to blossom under the heavens, something that would burn with such bright- ness that all the stars would be in awe. And the boy fell madly in love with the girl and promised to always find her, in this life and the next.” “That’s my favorite story.” Xuan smiled. “It’s the best one I’ve ever told, Ms. Steel.

lots of kids get the spirit–and when they have the spirit you have a scientist. It’s too late for them to get the spirit when they are in our universities, so we must attempt to explain these ideas to children.

Look in it,' he said, smiling slightly, as you do when you have given someone a present which you know will please him and he is unwrapping it before your eyes. I opened it. In the folder I found four 8×10 glossy photos, obviously professionally done; they looked like the kind of stills that the publicity departments of movie studios put out. The photos showed a Greek vase, on it a painting of a male figure who we recognized as Hermes. Twined around the vase the double helix confronted us, done in red glaze against a black background. The DNA molecule. There could be no mistake. 'Twenty-three or -four hundred years ago,' Fat said. 'Not the picture but the krater, the pottery.' 'A pot,' I said. 'I saw it in a museum in Athens. It's authentic. Thats not a matter of my own opinion; I'm not qualified to judge such matters; it's authenticity has been established by the museum authorities. I talked with one of them. He hadn't realized what the design shows; he was very interested when I discussed it with him. This form of vase, the krater, was the shape later used as the baptismal font. That was one of the Greek words that came into my head in March 1974, the word “krater”. I heard it connected with another Greek word: “poros”. The words “poros krater” essentially mean “limestone font”. ' There could be no doubt; the design, predating Christianity, was Crick and Watson's double helix model at which they had arrived after so many wrong guesses, so much trial-and-error work. Here it was, faithfully reproduced. 'Well?' I said. 'The so-called intertwined snakes of the caduceus. Originally the caduceus, which is still the symbol of medicine was the staff of- not Hermes-but-' Fat paused, his eyes bright. 'Of Asklepios. It has a very specific meaning, besides that of wisdom, which the snakes allude to; it shows that the bearer is a sacred person and not to be molested...which is why Hermes the messenger of the gods, carried it.' None of us said anything for a time. Kevin started to utter something sarcastic, something in his dry, witty way, but he did not; he only sat without speaking. Examining the 8×10 glossies, Ginger said, 'How lovely!' 'The greatest physician in all human history,' Fat said to her. 'Asklepios, the founder of Greek medicine. The Roman Emperor Julian-known to us as Julian the Apostate because he renounced Christianity-conside​red Asklepios as God or a god; Julian worshipped him. If that worship had continued, the entire history of the Western world would have basically changed

When a scientist doesn’t know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty darn sure of what the result is going to be, he is in some doubt.

We are each a product of our biological endowments, culture, and personal history. Culture ideology and cultural events along with transmitted cultural practices influences each of us. We are each the product of our collective interchanges. Our county’s domestic and interlinked international conflicts fuse us together. We are each a molecule in the helix of human consciousness joined in a physical world. We form a coil of connective tissue soldered together by cultural links.

One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid.

How many genetic engineers does it take to screw in a lightbulb? Eleven—one to do the work, and the other ten to figure out why it doesn’t have a double helix.” “What’s the definition of a virgin genetic engineer? A nerd with too many pocket protectors.

You are comprised of 84 minerals, 23 elements, and 8 gallons of water spread across 38 trillion cells. You have been built up from nothing by the spare parts of the Earth you have consumed, according to a set of instructions hidden in a double helix and small enough to be carried by a sperm. You are recycled butterflies, plants, rocks, streams, firewood, wolf fur, and shark teeth, broken down to their smallest parts and rebuilt into our planet's most complex living thing. You are not living on Earth. You are Earth.

If you expected science to give all the answers to the wonderful questions about what we are, where we’re going, what the meaning of the universe is and so on, then I think you could easily become disillusioned and then look for some mystic answer to these problems.

What, then, is the meaning of it all? What can we say to dispel the mystery of existence? If we take everything into account, not only what the ancients knew, but all of what we know today that they didn’t know, then I think that we must frankly admit that we do not know.

I recently asked more than seventy eminent researchers if they would have done I their work differently if they had thought Darwin's theory was wrong. The responses were all the same: no. I also examined the outstanding biodiscoveries of the past century: the discovery of the double helix; the characterization of the ribosome: the mapping of genomes; research on medications and drug reactions: improvements in food production and sanitation; the development of new surgeries; and others. I even queried biologists working in areas where one would expect the Darwinian paradigm to have most benefited research, such as the emergence of resistance to antibiotics and pesticides. Here, as elsewhere, I found that Darwin's theory had provided no discernible guidance, but was brought in, after the breakthroughs, as an interesting narrative gloss.

(...) The floor itself was inscribed with a mosaic in the data-pattern mode, representing the entire body of the Curia case law. At the center, small icons representing constitutional principles sent out lines to each case in which they were quoted; bright lines for controlling precedent, dim lines for dissenting opinions or dicta. Each case quoted in a later case sent out additional lines, till the concentric circles of floor-icons were meshed in a complex network. The jest of the architect was clear to Phaethon. The floor mosaic was meant to represent the fixed immutability of the law; but the play of light from the pool above made it seem to ripple and sway and change with each little breeze. Above the floor, not touching it, without sound or motion, hovered three massive cubes of black material. These cubes were the manifestations of the Judges. The cube shape symbolized the solidity and implacable majesty of the law. Their high position showed they were above emotionalism or earthly appeals. The crown of each cube bore a thick-armed double helix of heavy gold. The gold spirals atop the black cubes were symbols of life, motion, and energy. Perhaps they represented the active intellects of the Curia. Or perhaps they represented that life and civilization rested on the solid foundations of the law. If so, this was another jest of the architect. The law, it seemed, rested on nothing.

Today, and let us celebrate this fact, We can eat the light of our beloved, warmed by compassion or cooled by intellectual feeling. And if we are surprised, and some of us disappointed, that the light is now only green - well, such was the vital probability awaiting us. We have, after all, an increase in the energy available for further evolution; we can use the energy of our position relative to the probabilities in the future to reach the future we desire. The full use of this energy is just beginning to be explored, and we have the opportunity open to few generations to create our best opportunities. We must not slacken in our desire now if we desire a future. The pressure of probabilities on the present increases the momentum of evolution, and as the voluble helix turns, and turns us away from our improbable satiation, we can see that the shadow cast on the present from the future is not black but rainbowed, brilliant with lemon yellow, plum-purple, and cherry-red. I have no patience with those who say that their desire for light is satisfied. Or that they are bored. I have myself a still unsatisfied appetite for green: eucalyptus, celadon, tourmaline, and apple. ("Desire")

By studying ancient symbols, Bruce had discovered that genetic tampering was commonplace throughout the ages, indicated by the frequent display of the rod of Asclepius, a winged staff with double-helix serpents created by ancient cultures who worshiped serpents and the demigods that tampered with human genetics.

The currency of evolution is neither hunger nor pain, but rather copies of DNA helixes. Just as the economic success of a company is measured only by the number of dollars in its bank account, not by the happiness of its employees, so the evolutionary success of a species is measured by the number of copies of its DNA. If no more DNA copies remain, the species is extinct, just as a company without money is bankrupt. If a species boasts many DNA copies, it is a success, and the species flourishes. From such a perspective, 1,000 copies are always better than a hundred copies. This is the essence of the Agricultural Revolution: the ability to keep more people alive under worse conditions. Yet why should individuals care about this evolutionary calculus? Why would any sane person lower his or her standard of living just to multiply the number of copies of the Homo sapiens genome? Nobody agreed to this deal: the Agricultural Revolution was a trap.

But, of course, a child won’t learn what you teach him.

As a thought experiment, von Neumann's analysis was simplicity itself. He was saying that the genetic material of any self-reproducing system, whether natural or artificial, must function very much like a stored program in a computer: on the one hand, it had to serve as live, executable machine code, a kind of algorithm that could be carried out to guide the construction of the system's offspring; on the other hand, it had to serve as passive data, a description that could be duplicated and passed along to the offspring. As a scientific prediction, that same analysis was breathtaking: in 1953, when James Watson and Francis Crick finally determined the molecular structure of DNA, it would fulfill von Neumann's two requirements exactly. As a genetic program, DNA encodes the instructions for making all the enzymes and structural proteins that the cell needs in order to function. And as a repository of genetic data, the DNA double helix unwinds and makes a copy of itself every time the cell divides in two. Nature thus built the dual role of the genetic material into the structure of the DNA molecule itself.

Wielding imaging techniques such as X-ray crystallography, which is what Rosalind Franklin used to find evidence of the structure of DNA, structural biologists try to discover the three-dimensional shape of molecules. Linus Pauling worked out the spiral structure of proteins in the early 1950s, which was followed by Watson and Crick’s paper on the double-helix structure of DNA.

Surprisingly, palindromes appear not just in witty word games but also in the structure of the male-defining Y chromosome. The Y's full genome sequencing was completed only in 2003. This was the crowning achievement of a heroic effort, and it revealed that the powers of preservation of this sex chromosome have been grossly underestimated. Other human chromosome pairs fight damaging mutations by swapping genes. Because the Y lacks a partner, genome biologists had previously estimated that its cargo was about to dwindle away in perhaps as little as five million years. To their amazement, however, the researchers on the sequencing team discovered that the chromosome fights withering with palindromes. About six million of its fifty million DNA letters form palindromic sequences-sequences that read the same forward and backward on the two strands of the double helix. These copies not only provide backups in case of bad mutations, but also allow the chromosome, to some extent, to have sex with itself-arms can swap position and genes are shuffled. As team leader David Page of MIT has put it, "The Y chromosome is a hall of mirrors.

Expect an army of Vigil drones, nearly as a many Praesidis guards, a Machim ground detachment of super-soldiers and at least one Inquisitor. Oh, and security barriers everywhere. Possibly some of those mechs we met on Helix Retention, too. You Humans have kicked off a shitstorm of epic proportions.” Alex spread her arms wide in an exagerrated shrug. “It’s one of our best skills.

and Muller deepened this understanding by demonstrating that genes were physical—material—structures carried on chromosomes. Avery advanced this understanding of genes by identifying the chemical form of that material: genetic information was carried in DNA. Watson, Crick, Wilkins, and Franklin solved its molecular structure as a double helix, with two paired, complementary strands.

If your personal genome sequence was written out longhand, it would be a three-billion-word book. The King James Version of the Bible has 783,137 words, so your genetic code is the equivalent of nearly four thousand Bibles. And if your personal genome sequence were an audio book and you were read at a rate of one double helix per second, it would take nearly a century to put you into words!

Bohm believes the same is true at our own level of existence. Space is not empty. It is full, a plenum as opposed to a vacuum, and is the ground for the existence of everything, including ourselves. The universe is not separate from this cosmic sea of energy, it is a ripple on its surface, a comparatively small "pattern of excitation" in the midst of an unimaginably vast ocean. "This excitation pattern is relatively autonomous and gives rise to approximately recurrent, stable and separable projections into a three-dimensional explicate order of manifestation, " states Bohm.1 2 In other words, despite its apparent materiality and enormous size, the universe does not exist in and of itself, but is the stepchild of something far vaster and more ineffable. More than that, it is not even a major production of this vaster something, but is only a passing shadow, a mere hiccup in the greater scheme of things. This infinite sea of energy is not all that is enfolded in the implicate order. Because the implicate order is the foundation that has given birth to everything in our universe, at the very least it also contains every subatomic particle that has been or will be; every configuration of matter, energy, life, and consciousness that is possible, from quasars to the brain of Shakespeare, from the double helix, to the forces that control the sizes and shapes of galaxies. And even this is not all it may contain. Bohm concedes that there is no reason to believe the implicate order is the end of things. There may be other undreamed of orders beyond it, infinite stages of further development.

DNA molecule, as you will almost certainly remember from countless television programs if not school biology, is made up of two strands, connected by rungs to form the celebrated twisted ladder known as a double helix. Your DNA is simply an instruction manual for making you. A length of DNA is divided into segments called chromosomes and shorter individual units called genes. The sum of all your genes is the genome.

The currency or evolution is neither hunger nor pain, but rather copies of DNA helixes. Just as the economic success of a company is measured only by the number of dollars in its bank account, not by the happiness of its employees, so the evolutionary success of a species is measured by the number of copies of its DNA... This is the essence of the Agricultural Revolution: the ability to keep more people alive under worse conditions.

Tags [distinctive agent features observable by other agents] almost always define the network by delimiting the critical interactions, the major connections. Tags acquire this role because the adaptive processes that modify cas [complex adaptive systems] select for tags that mediate useful interactions and against tags that cause malfunctions. That is, agents with useful tags spread, while agents with malfunctioning tags cease to exist.

a .22 shell is used to fire stainless-steel projectiles dipped in a DNA solution at a stem or leaf of the target plant. If all goes well, some of the DNA will pierce the wall of some of the cells’ nuclei and elbow its way into the double helix: a bully breaking into a line dance. If the new DNA happens to land in the right place—and no one yet knows what, or where, that place is—the plant grown from that cell will express the new gene. That’s it? That’s it.

Of all the things we could have said to the people of other planets, we chose to fire into space a capsule containing the model for the double helix structure, the composition of DNA and the formation of nucleotides. Not a message that declared: it is sunny here it also rains a lot we love colours and dope we sign and we dance we cook up a storm with anything we can find we are fucked up in too many ways but we are a funny bunch so may we request the pleasure of your company

No government has the right to decide on the truth of scientific principles, nor to prescribe in any way the character of the questions investigated. Neither may a government determine the aesthetic value of artistic creations, nor limit the forms of literary or artistic expression. Nor should it pronounce on the validity of economic, historic, religious, or philosophical doctrines. Instead it has a duty to its citizens to maintain the freedom, to let those citizens contribute to the further adventure and the development of the human race. Thank you.

The Three Sisters offer us a new metaphor for an emerging relationship between indigenous knowledge and Western science, both of which are rooted in the earth. I think of the corn as traditional ecological knowledge, the physical and spiritual framework that can guide the curious bean of science, which twines like a double helix. The squash creates the ethical habitat for coexistence and mutual flourishing. I envision a time when the intellectual monoculture of science will be replaced with a polyculture of complementary knowledges. And so all may be fed.

By then Watson and Crick had a pretty good idea of DNA’s structure. It had two sugar-phosphate strands that twisted and spiraled to form a double-stranded helix. Protruding from these were the four bases in DNA: adenine, thymine, guanine, and cytosine, now commonly known by the letters A, T, G, and C. They came to agree with Franklin that the backbones were on the outside and the bases pointed inward, like a twisted ladder or spiral staircase. As Watson later admitted in a feeble attempt at graciousness, “Her past uncompromising statements on this matter thus reflected first-rate science

DNA is the basis for all life on Earth. It has a double-helix structure, like a spiral staircase, which was discovered by Francis Crick and James Watson in the Cavendish lab at Cambridge in 1953. The two strands of the double helix are linked by pairs of nitrogenous bases like the treads in a spiral staircase. There are four kinds of nitrogenous bases: cytosine, guanine, adenine and thymine. The order in which the different nitrogenous bases occur along the spiral staircase carries the genetic information that enables the DNA molecule to assemble an organism around it and reproduce itself.

I’ve always been very one-sided about science and when I was younger I concentrated almost all my effort on it. I didn’t have time to learn and I didn’t have much patience with what’s called the humanities, even though in the university there were humanities that you had to take. I tried my best to avoid somehow learning anything and working at it. It was only afterwards, when I got older, that I got more relaxed, that I’ve spread out a little bit. I’ve learned to draw and I read a little bit, but I’m really still a very one-sided person and I don’t know a great deal. I have a limited intelligence and I use it in a particular direction.

Charles Darwin formulated his idea 50 years before genes, 100 before the double helix, and 150 before the human genome was read. But they all say the same thing. Life is a chemical reaction. Life is derived from what came before. Life is imperfect copying. Life is the accumulation and refinement of information embedded in DNA. Natural selection explains how, once it had started, life evolved on Earth. We busy ourselves refining the theory, and working out the details with a scrutiny and precision that has been enabled and invigorated by reading genome after genome, and crunching those numbers until comprehensible patterns emerge. We are the data.

They’d been sleeping on the floor next to the bed ever since the boys had died. This was because the boys, though they were eleven and thirteen, coming into their male sounds and snores, had shared the bed with them every night, the limbs of the four Khuranas tangled ferociously, like a sprig of roots, dreams and sleep patterns merging and helixing, so that on one particular night, when Nakul screamed in his sleep, so did the other three, and the family woke with a common hoarse throat, looking around for intruders and then laughing. “We’re like tightly packed molecules,” Tushar had said, invoking the words of his science teacher and squeezing his mother close.

The currency of evolution is neither hunger nor pain, but rather copies of DNA helixes. Just as the economic success of a company is measured only by the number of dollars in its bank account, not by the happiness of its employees, so the evolutionary success of a species is measured by the number of copies of its DNA. If no more DNA copies remain, the species is extinct, just as a company without money is bankrupt. If a species boasts many DNA copies, it is a success, and the species flourishes. From such a perspective, 1,000 copies are always better than a hundred copies. This is the essence of the Agricultural Revolution: the ability to keep more people alive under worse conditions.

The diversity of 'cas'(complex adaptive systems) is a dynamic patter, often persistent and coherent like the standing wave we alluded to earlier. If you disturb the wave, say with a stick or paddle, the wave quickly repairs itself once the disturbance is removed. Similarly in 'cas', a pattern of interactions disturbed by the extinction of component agents often reasserts itself, though the new agents may differ in detail from the old. There is, however, a crucial difference between the standing wave pattern and 'cas' patterns: 'cas' patterns evolve. The diversity observed in 'cas' is the product of progressive adaptations. Each new adaptation opens the possibility for further interactions and new niches.

You see, one thing is, I can live with doubt and uncertainty and not knowing. I think it’s much more interesting to live not knowing than to have answers which might be wrong. I have approximate answers and possible beliefs and different degrees of certainty about different things, but I’m not absolutely sure of anything and there are many things I don’t know anything about, such as whether it means anything to ask why we’re here, and what the question might mean. I might think about it a little bit and if I can’t figure it out, then I go on to something else, but I don’t have to know an answer, I don’t feel frightened by not knowing things, by being lost in a mysterious universe without having any purpose, which is the way it really is so far as I can tell. It doesn’t frighten me.

Being a rape victim just sucked, for a while. Sometimes, though, without meaning to be, I was proud: I have suffered, and that entitled me to something, but I didn’t know what. Everyone seemed to be reaching deep into the crevices of their souls to find oozing gobs of pain, and if that pain was parented by some distant generation that spent brutal winters chasing diminishing herds after its own numbers had dwindled from the settler’s diseases and brute force, it seems ever more potent, wrapped around our DNA double-helixes. A pain so old begins to feel like predestination, locking every generation into more, whether that’s the truth or something I tell myself because I like the pain. Even more, I savor the twisted prestige of inheriting old hurts most people only read about in history books.

Being a rape victim just sucked, for a while. Sometimes, though, without meaning to be, I was proud: I have suffered, and that entitled me to something, but I didn’t know what. Everyone seemed to be reaching deep into the crevices of their souls to find oozing gobs of pain, and if that pain was parented by some distant generation that spent brutal winters chasing diminishing herds after its own numbers had dwindled from the settler’s diseases and brute force, it seems ever more potent, wrapped around our DNA double-helixes. A pain so old begins to feel like predestination, locking every generation into more, whether that’s the truth or something I tell myself because I like the pain Even more, I savor the twisted prestige of inheriting old hurts most people only read about in history books. ~ 93-94

Al Hershey had sent me a long letter from Cold Spring Harbor summarizing the recently completed experiments by which he and Martha Chase established that a key feature of the infection of a bacterium by a phage was the injection of the viral DNA into the host bacterium. Most important, very little protein entered the bacterium. Their experiment was thus a powerful new proof that DNA is the primary genetic material. Nonetheless, almost no one in the audience of over four hundred microbiologists seemed interested as I read long sections of Hershey’s letter. Obvious exceptions were André Lwoff, Seymour Benzer, and Gunther Stent, all briefly over from Paris. They knew that Hershey’s experiments were not trivial and that from then on everyone was going to place more emphasis on DNA. To most of the spectators, however, Hershey’s name carried no weight.

One of the most powerful tools for discovering structure is ‘X-ray diffraction’ or, because it is always applied to crystals of the substance of interest, ‘X-ray crystallography’. The technique has been a gushing fountain of Nobel prizes, starting with Wilhelm Röntgen’s discovery of X-rays (awarded in 1901, the first physics prize), then William and his son Laurence Bragg in 1915, Peter Debye in 1936, and continuing with Dorothy Hodgkin (1964), and culminating with Maurice Wilkins (but not Rosalind Franklin) in 1962, which provided the foundation of James Watson’s and Francis Crick’s formulation of the double-helix structure of DNA, with all its huge implications for understanding inheritance, tackling disease, and capturing criminals (a prize shared with Wilkins in 1962). If there is one technique that is responsible for blending biology into chemistry, then this is it. Another striking feature of this list is that the prize has been awarded in all three scientific categories: chemistry, physics, and physiology and medicine, such is the range of the technique and the illumination it has brought.

The helix contains two intertwined strands of DNA. It is "right-handed"-twisting upward as if driven by a right-handed screw. Across the molecule, it measures twenty-three angstroms-one-thousandth of one-thousandth of a millimeter. One million helices stacked side by side would fit in this letter: o. the biologist John Sulston wrote, "We see it as a rather stubby double helix, for they seldom show its other striking feature: it is immensely long and thin. In every cell in your body, you have two meters of the stuff; if we were to draw a scaled-up picture of it with the DNA as thick as sewing thread, that cell's worth would be about 200 kilometers long." Each strand of DNA, recall, is a long sequence of "bases"-A,T,G,and C. The bases are linked together by the sugar-phosphate backbone. The backbone twists on the outside, forming a spiral. The bases face in, like treads in a circular staircase. The opposite strand contains the opposing bases: A matched with T and G matched with C. Thus, both strands contain the same information-except in a complementary sense: each is a "reflection," or echo, of the other (the more appropriate analogy is a yin-and-yang structure). Molecular forces between the A:T and G:C pairs lock the two strands together, as in a zipper. A double helix of DNA can thus be envisioned as a code written with four alphabets-ATGCCCTACGGGCCCATCG...-forever entwined with its mirror-image code.

In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by [Frederick] Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures. [Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips]

Turning and climbing, the double helix evolved to an operation which had always existed as a possibility for mankind, the eating of light. The appetite for light was ancient. Light had been eaten metaphorically in ritual transubstantiations. Poets had declared that to be is to be a variable of light, that this peach, and even this persimmon, is light. But the peach which mediated between light and the appetite for light interfered with the taste of light, and obscured the appetite it aroused. The appetite for actual light was at first appeased by symbols. But the simple instruction, promulgated during the Primordification, to taste the source of the food in the food, led to the ability to eat light. Out of the attempt to taste sources came the ability to detect unpleasant chemicals. These had to be omitted. Eaters learned to taste the animal in the meat, and the animal's food and drink, and to taste the waters and sugars in the melon. The discriminations grew finer - children learned to eat the qualities of the pear as they ate its flesh, and to taste its slow ripening in autumn sunlight. In the ripeness of the orange they recapitulated the history of the orange. Two results occurred. First, the children were quick to surpass the adults, and with their unspoiled tastes, and their desire for light, they learned the flavor of the soil in which the blueberry grew, and the salty sweetness of the plankton in the sea trout, but they also became attentive to the taste of sunlight. Soon there were attempts to keep fruit of certain vintages: the pears of a superbly comfortable autumn in Anjou, or the oranges of Seville from a year so seasonless that their modulations of bouquet were unsurpassed for decades. Fruit was eaten as a retrospective of light. Second, children of each new generation grew more clearly, until children were shaped as correctly as crystals. The laws governing the operations of growth shone through their perfect exemplification. Life became intellectually transparent. ("Desire")

I shifted one strap over my shoulder, then the other. I circled my head around and swiveled my hips, creating a sort of hula hoop helix, a study in the curves of a woman's body. He reached for me, but I stepped back, just beyond his reach. "Not yet..." "Argh," he said, but he said it with a smile. "Yes, mademoiselle." I turned around and grazed the tops of his knees with my butt, then spread my legs and bent over, because I knew the dress would ride up. I'd known this Hervé Léger was good for dancing, but I hadn't known until then that it was made for holding men entranced. I stood up while his hand moved up and down my inner thigh, and then his other hand joined in. He unzipped the back of the dress and it fell to the ground with an unsexy sandbag-like thud. I had never stood in front of a man in just a bra, panties, and heels. My first instinct was to be embarrassed, to want to cover up or turn down the lights, to jump on him so he wouldn't have such a complete view of every inch of me. Yet his gaze only grew in intensity. But then Pascal pulled me at the knees so I buckled and tripped on the way to his lap. He flicked my bra open and off so my arms flew wildly in front of me. Then, in a rather impressive move, he slid my panties off and circled me around me so I was the one sitting and he stood over me. All of a sudden, he had the control. "Hey," I said. A quiver came into my voice now that he was on top and I didn't know what to do. Pascal unbuttoned his shirt and unbuckled his belt. I got the picture and began to kick off my shoes, but he stopped me. "Leave them on," he said. "You look so fucking sexy in those heels." I blushed, but now wasn't the time to be sheepish. He leaned over me. I squeezed his waist with my legs and held his neck in the crook of my elbows so I could keep his face to mine. We rocked together forcefully but in sync. He swiftly slid off his boxer briefs and put my hand on him. He was even harder than before, harder than I had ever felt with Elliott. Pascal was roaring in triumph as he sat over me, himself in hand.