Genes Work Quotes

If you are lazy, and accept your lot, you may live in it. If you are willing to work, you can write your name anywhere you choose.

Just as blueprints don't necessarily specify blue buildings, selfish genes don't necessarily specify selfish organisms. As we shall see, sometimes the most selfish thing a gene can do is build a selfless brain. Genes are a play within a play, not the interior monologue of the players.

Ancient astronauts didn't build the pyramids. Human beings built the pyramids, because they're clever and they work hard.

What i'm trying to tell you," Min said, "is that im going to grow up to be one of those chubby old ladies. It's in my genes. Like self raising flour. i'm going to pouf." "thats going to work out well for me," Cal said. "because i'm going to grow up to be one of those horny old men who chases chubby old ladies around the couch.

Improving daily work is even more important than doing daily work.

Being able to take needless work out of the system is more important than being able to put more work into the system.

The fall of one regime does not bring in a utopia. Rather, it opens the way for hard work and long efforts to build more just social, economic,and political relationships and the eradication of other forms of injustices and oppression.

You want to hit the gym with me?" Ellie wrinkled her button nose. "Gym? Me?" I eyed her skinny self. "You mean you're naturally that gorgeous?" She laughed, flushing a little. "I have good genes." "Yeah, well I have to work-out to fit into mine.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker.

Sometimes, the only things that make you feel good are the same ones that worked when you were five. Yes, I slammed the door

Intelligent life on a planet comes of age when it first works out the reason for its own existence.

I discovered that our genes are not destiny and that in order to change, we have to become consciously aware of our habits and thought patterns, which have been shaped by the people we care for most.

It was a compound of self-reliance, hard knocks, heart hunger, unceasing work, and generosity. There was no form of suffering with which the girl could not sympathize, no work she was afraid to attempt, no subject she had investigated she did not understand. These things combined to produce a breadth and depth of character altogether unusual.

Before I ever knew what the word Entrepeneur was, I realized in America and in the Western part of the world in general, you are given the opportunity to be whatever you want to be. And that is all anyone should ever expect from the Capitalist system. The rest is up to you. It's up to you to educate yourself. It's up to you to learn speaking skills and people skills. It's up to you to try (and usually fail, but to try again) all sorts of ventures. The rest is a combination of hard work, being at the right place ...at the right time...with the right thing...oh yes...and more (never ending) hard work.

Meditation works in many layers. It works in our genes, in our DNA

Contrary to popular belief, the gene-centered theory of evolution does not imply that the point of all human striving is to spread our genes.

Thinking is computation, I claim, but that does not mean that the computer is a good metaphor for the mind. The mind is a set of modules, but the modules are not encapsulated boxes or circumscribed swatches on the surface of the brain. The organization of our mental modules comes from our genetic program, but that does not mean that there is a gene for every trait or that learning is less important than we used to think. The mind is an adaptation designed by natural selection, but that does not mean that everything we think, feel, and do is biologically adaptive. We evolved from apes, but that does not mean we have the same minds as apes. And the ultimate goal of natural selection is to propagate genes, but that does not mean that the ultimate goal of people is to propagate genes.

Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker.

Of course genes can’t pull the levers of our behavior directly. But they affect the wiring and workings of the brain, and the brain is the seat of our drives, temperaments and patterns of thought. Each of us is dealt a unique hand of tastes and aptitudes, like curiosity, ambition, empathy, a thirst for novelty or for security, a comfort level with the social or the mechanical or the abstract. Some opportunities we come across click with our constitutions and set us along a path in life.

technical debt’ that is not being paid down. It comes from taking shortcuts, which may make sense in the short-term. But like financial debt, the compounding interest costs grow over time. If an organization doesn’t pay down its technical debt, every calorie in the organization can be spent just paying interest, in the form of unplanned work.

I realize now that no simple, single-factor theory of depression will ever work. Depression is partly in our genes, partly in our childhood experience, partly in our way of thinking, partly in our brains, partly in our ways of handling emotions. It affects our whole being.

Luther says that vocations are a “mask from God. That is, God hides Himself in the workplace, the family, the Church, and the seemingly secular society

To my way of thinking and working, the greatest service a piece of fiction can do any reader is to leave him with a higher ideal of life than he had when he began. If in one small degree it shows him where he can be…gentler, saner, cleaner, kindlier…it is a wonder-working book. If it opens his eyes to one beauty in nature he never saw for himself and leads him one step toward the God of the Universe, it is a beneficial book…

There never was a moment in my life, when I felt so in the Presence, as I do now. I feel as if the Almighty were so real, and so near, that I could reach out and touch Him, as I could this wonderful work of His, if I dared. I feel like saying to Him: 'To the extent of my brain power I realize Your presence, and all it is in me to comprehend of Your power. Help me to learn, even this late, the lessons of Your wonderful creations. Help me to unshackle and expand my soul to the fullest realization of Your wonders. Almighty God, make me bigger, make me broader!

Focus on whether you are fulfilling your own potential than comparing yourself to someone else. The fact that you have a natural limit to any specific ability has nothing too do with whether you are reaching the ceiling of your capabilities. People get so caught up in the fact that they have limits that they rarely exert the effort required to get close to them. Genes can not make you successful if you’re not doing the work. Until you work as hard as those you admire, don’t explain away their success as luck.

Emerging science tells us that the genes we inherit aren’t fixed; they are influenced by their environment, beginning in utero and continuing throughout our lives. The groundbreaking discovery of epigenetics tells a new story about our ability to change.

Unplanned work is what prevents you from doing it. Like matter and antimatter, in the presence of unplanned work, all planned work ignites with incandescent fury, incinerating everything around it.

It was harder to work out that there was a question than to think of the answer.

The priesthood of all believers” did not make everyone into church workers; rather, it turned every kind of work into a sacred calling.

For every bad man and woman I have ever known, I have met . . . an overwhelming number of thoroughly clean and decent people who still believe in God and cherish high ideals, and it is upon the lives of these people that I base what I write. To contend that this does not produce a picture true to life is idiocy. It does. It produces a picture true to ideal life; to the best that good men and good women can do at level best. I care very little for the . . . critics who proclaim that there is no such thing as a moral man, and that my pictures of life are sentimental and idealized. They are! And I glory in them! They are straight, living pictures from the lives of men and women of morals, honor, and loving kindness. . . . Such a big majority of book critics and authors have begun to teach, whether they really believe it or not, that no book is true to life unless it is true to the worst in life.

It was that time of life: Talents were rising to the surface, weaknesses were beginning to show through, we were finding out what kinds of people we would be. Some would turn out beautiful, some funny, some shy. Some would be smart, others smarter. THe chubby ones would likely always be chubby. THe beloved, I sensed, would be beloved for life. And I worried that loneliness might work that way, too. Maybe loneliness was imprinted in my genes, lying dormant for years but now coming into full bloom.

An aphrodisiac will disappear, delusional, like permanence or wealth - a shimmering, as if love were a ghost - and yet my passion for you seethes and sears without an end. Late April leaves can’t crave caress of dew, sunlight’s sweet splash, more than I pine for your embrace, us turned to one; when harsh reversals scar, the thought of you will salve like summer wind in autumn; deep red blood surging along with mine, staid genes worked hot from your electric charms, as all my moods succumb to your sweet fire, and perfect wit. Now you are all I live for - loving you - in fleeting world of lies, you are the truth.

Mr L Prosser was, as they say, only human. In other words he was a carbon-based life form descended from an ape. More specifically he was forty, fat and shabby and worked for the local council. Curiously enough, though he didn't know it, he was also a direct male-line descendant of Genghis Khan, though intervening generations and racial mixing had so juggled his genes that he had no discernible Mongoloid characteristics, and the only vestiges left in Mr L Prosser of his mighty ancestry were a pronounced stoutness about the tum and a predilection for little fur hats.

In many ways, the idea of a shared stock of genes drifting through the galaxy is far easier to accept than the daunting notion that none of us may ever have the intellectual capacity to understand how life truly works.

Left unchecked, technical debt will ensure that the only work that gets done is unplanned work!

Realizing that one does not have to worry about what will happen, that the future is in God's hands, is liberating.

Of course you do, child," said mother. "Families were made to cling together, and stand by each other in every circumstance of life—joy or sorrow. Of course you need your family.

I’M LOSING FAITH IN MY FAVORITE COUNTRY Throughout my life, the United States has been my favorite country, save and except for Canada, where I was born, raised, educated, and still live for six months each year. As a child growing up in Waterloo, Ontario, Canada, I aggressively bought and saved baseball cards of American and National League players, spent hours watching snowy images of American baseball and football games on black and white television and longed for the day when I could travel to that great country. Every Saturday afternoon, me and the boys would pay twelve cents to go the show and watch U.S. made movies, and particularly, the Superman serial. Then I got my chance. My father, who worked for B.F. Goodrich, took my brother and me to watch the Cleveland Indians play baseball in the Mistake on the Lake in Cleveland. At last I had made it to the big time. I thought it was an amazing stadium and it was certainly not a mistake. Amazingly, the Americans thought we were Americans. I loved the United States, and everything about the country: its people, its movies, its comic books, its sports, and a great deal more. The country was alive and growing. No, exploding. It was the golden age of life, liberty, and the pursuit of happiness. The American dream was alive and well, but demanded hard work, honesty, and frugality. Everyone understood that. Even the politicians. Then everything changed. Partly because of its proximity to the United States and a shared heritage, Canadians also aspired to what was commonly referred to as the American dream. I fall neatly into that category. For as long as I can remember I wanted a better life, but because I was born with a cardboard spoon in my mouth, and wasn’t a member of the golden gene club, I knew I would have to make it the old fashioned way: work hard and save. After university graduation I spent the first half of my career working for the two largest oil companies in the world: Exxon and Royal Dutch Shell. The second half was spent with one of the smallest oil companies in the world: my own. Then I sold my company and retired into obscurity. In my case obscurity was spending summers in our cottage on Lake Rosseau in Muskoka, Ontario, and winters in our home in Port St. Lucie, Florida. My wife, Ann, and I, (and our three sons when they can find the time), have been enjoying that “obscurity” for a long time. During that long time we have been fortunate to meet and befriend a large number of Americans, many from Tom Brokaw’s “Greatest Generation.” One was a military policeman in Tokyo in 1945. After a very successful business carer in the U.S. he’s retired and living the dream. Another American friend, also a member of the “Greatest Generation”, survived The Battle of the Bulge and lived to drink Hitler’s booze at Berchtesgaden in 1945. He too is happily retired and living the dream. Both of these individuals got to where they are by working hard, saving, and living within their means. Both also remember when their Federal Government did the same thing. One of my younger American friends recently sent me a You Tube video, featuring an impassioned speech by Marco Rubio, Republican senator from Florida. In the speech, Rubio blasts the spending habits of his Federal Government and deeply laments his country’s future. He is outraged that the U.S. Government spends three hundred billion dollars, each and every month. He is even more outraged that one hundred and twenty billion of that three hundred billion dollars is borrowed. In other words, Rubio states that for every dollar the U.S. Government spends, forty cents is borrowed. I don’t blame him for being upset. If I had run my business using that arithmetic, I would be in the soup kitchens. If individual American families had applied that arithmetic to their finances, none of them would be in a position to pay a thin dime of taxes.

I have no way of knowing whether you, who eventually will read this record, like stories or not. If you do not, no doubt you have turned these pages without attention. I confess that I love them. Indeed, it often seems to me that of all the good things in the world, the only ones humanity can claim for itself are stories and music; the rest, mercy, beauty, sleep, clean water and hot food (as the Ascian would have said) are all the work of the Increate. Thus, stories are small things indeed in the scheme of the universe, but it is hard not to love best what is our own—hard for me, at least.

I shall not vote for Sen. Obama and it will not be because he—like me and like all of us—carries African genes. And I shall not be voting for Mrs. Clinton, who has the gall to inform me after a career of overweening entitlement that there is 'a double standard' at work for women in politics; and I assure you now that this decision of mine has only to do with the content of her character. We will know that we have put this behind us when [...] we have outgrown and forgotten the original prejudice.

What you are lies with you. If you are lazy, and accept your lot, you may live in it. If you are willing to work, you can write your name anywhere you choose, among the only ones who live beyond the grave in this world, the people who write books that help, make exquisite music, carve statues, paint pictures, and work for others. Never mind the calico dress, and the coarse shoes. Work at you books, and before long you will hear yesterday's tormentors boasting that they were once classmates of yours.

Gay rights aren't predicated on being born gay or having the right gene. Gay rights are predicated on having choice and consent. If you're a man and you can find another man that consents to have sex with you, it's the consent that gives you the right to have sex with him. Genetics are irrelevant when it comes to sexual rights. Just as gay rights are based on choice and consent, so are prostitution rights. All sexual rights are based on choice and consent.

A cancer growing in someone's body will go on growing in spite of denial. And a complex combination of genes that work together to make you intelligent as well as hierarchical will still handicap you whether you acknowledge it or not.

Remember, it goes beyond reducing WIP. Being able to take needless work out of the system is more important than being able to put more work into the system.

We thank you, God, for this boy and his awesome genes. Keep up the good work.

When God blesses us, He almost always does it through other people.

Kandel argues that when psychotherapy changes people, 'it presumably does so through learning, by producing changes in gene expression that alter the strength of synaptic connections, and structural changes that alter the anatomical pattern of interconnections between nerve cells of the brain.' Psychotherapy works by going deep into the brain and its neurons and changing their structure by turning on the right genes. Psychiatrist Dr. Susan Vaughan has argued that the talking cure works by 'talking to neurons,' and that an effective psychotherpist or psychoanalyst is a 'microsurgeon of the mind' who helps patients make needed alterations in neuronal networks.

Who would appreciate such candor? No one. None of us really likes honesty. We prefer deception –but only when it is unabashedly flattering or artfully camouflaged. Groups seem to need to believe that they are superior to others and that they have a purpose greater than just passing along their genes to the next generation. Individuals seem to need similar delusions – about who they are and why they do what they do. They need heroes, however fraudulent… Studies show that people are more likely to accept the opinion of a confident con man than the cautious view of someone who actually knows what he is talking about. And professionals who form overconfident opinions on the basis of incorrect readings of the facts are more likely to succeed than their more competent peers who display greater doubt. What’s more, deception works best, according to studies by psychologists, when the person doing the deceiving is fool enough to be deceived, too; that is, when he believes his own lies. That is why incompetent leaders – who are naïve enough to fall for their own guff – are such a danger to civilized life. If they are modern leaders, they must also delude themselves into thinking they know how to make the world a better place. Invariably, the answers they propose to problems are ones that bubble up from their own vanity, the essence of which is to make the rest of the world look just like them!

Tears were coursing down the faces of Kennedy’s moonstruck recruits. John Kennedy had inspired us with his vision. One by one, we left work to grieve in private. The flag was at half-staff in our hearts.

Different sorts of survival machine appear very varied on the outside and in their internal organs. An octopus is nothing like a mouse, and both are quite different from an oak tree. Yet in their fundamental chemistry they are rather uniform, and, in particular, the replicators that they bear, the genes, are basically the same kind of molecule in all of us—from bacteria to elephants. We are all survival machines for the same kind of replicator—molecules called DNA— but there are many different ways of making a living in the world, and the replicators have built a vast range of machines to exploit them. A monkey is a machine that preserves genes up trees, a fish is a machine that preserves genes in the water; there is even a small worm that preserves genes in German beer mats. DNA works in mysterious ways.

Had I life to live over, I see now where I could do more; but neighbour, believe me, my highest aspiration is to be a clean, thrifty housekeeper, a bountiful cook, a faithful wife, a sympathetic mother. That is life work for any woman, and to be a good woman is the greatest thing on earth. Never mind about the ladies; if you can honestly say of me, she is a good woman, you have paid me the highest possible tribute..... To be a good wife and mother is the end toward which I aspire. To hold the respect and love of my husband is the greatest object of my life.

According to the Reformers, each Christian has multiple vocations. We have callings in our work. We have callings in our families. We have callings as citizens in the larger society. And we have callings in the Church.

Everyone thinks that it was the big strong caveman who got the girl, and for the most part, that may have been true, but physical strength doesn't explain how our species created civilization. I think there was always some scrawny dreamer sitting at the edge of the firelight, who had the ability to imagine dangers, to look into the future in his imagination and see possibilities, and therefore survived to pass his genes on to the next generation. When the big ape men ended up running off the cliff or getting killed while trying to beat a mastodon into submission with a stick, the dreamer was standing back thinking 'Hey, that might work, but you need to run the mastodon off the cliff.' And, then he'd mate with the women left over after the go-getters got killed.

Treatments worked well enough for us to get by. Most people lived into old age, but the medication, like everything else, has never been free. Life was a privilege, not a right, apparently. Something you had to struggle for when you were unlucky enough to be born at the intersection of poverty and bad genes.

Science has discovered that, like any work of literature, the human genome is a text in need of commentary, for what Eliot said of poetry is also true of DNA: 'all meanings depend on the key of interpretation.' What makes us human, and what makes each of us his or her own human, is not simply the genes that we have buried into our base pairs, but how our cells, in dialogue with our environment, feed back to our DNA, changing the way we read ourselves. Life is a dialectic.

Don't!" cried Jamie. "Don't be bitter, Margaret. We don't know why, we never can know why things happen in this world exactly as they do; but this we know: We know that God is in His Heaven, that He is merciful to the extent of ordaining mercy; we know that if we disobey and take our own way and run contrary to His commandments, we are bitterly punished. And it is the most pitiful of laws that no man or woman can take their punishment alone in this world. It is the law that none of us can suffer without making someone else suffer, but in some way it must be that everything works out for the best, even if we can't possibly see how that could be when things are happening that hurt us so.

Not even much survives as memory. Many of the most notable names of the summer—Richard Byrd, Sacco and Vanzetti, Gene Tunney, even Charles Lindbergh—are rarely encountered now, and most of the others are never heard at all. So it is perhaps worth pausing for a moment to remember just some of the things that happened that summer: Babe Ruth hit sixty home runs. The Federal Reserve made the mistake that precipitated the stock market crash. Al Capone enjoyed his last summer of eminence. The Jazz Singer was filmed. Television was created. Radio came of age. Sacco and Vanzetti were executed. President Coolidge chose not to run. Work began on Mount Rushmore. The Mississippi flooded as it never had before. A madman in Michigan blew up a school and killed forty-four people in the worst slaughter of children in American history. Henry Ford stopped making the Model T and promised to stop insulting Jews. And a kid from Minnesota flew across an ocean and captivated the planet in a way it had never been captivated before. Whatever else it was, it was one hell of a summer.

That's the Teacher Gene at work, giving its bearer an extra sense. It's a little frightening. Maybe that's how people decide to become teachers. They have that extra sense, and once they have it, and know that they have it, they don't have any choice except to become a teacher.

Psychotherapy works by going deep into the brain and its neurons and changing their structure by turning on the right genes. Psychiatrist Dr. Susan Vaughan has argued that the talking cure works by "talking to neurons," and that an effective psychotherapist or psychoanalyst is a "microsurgeon of the mind" who helps patients make needed alterations in neuronal networks.

We can now give you a biological reason why cramming doesn’t work,” says Dr. Tully. The best way to prepare for a final exam is to mentally review the material periodically during the day, until the material becomes part of your long-term memory. This may also explain why emotionally charged memories are so vivid and can last for decades. The CREB repressor gene is like a filter, cleaning out useless information. But if a memory is associated with a strong emotion, it can either remove the CREB repressor gene or increase levels of the CREB activator gene.

As we’re about to see, by striving for even greater genetic perfection we might be eliminating a lot more than just millions of people who don’t fit the societal norms we’ve created. We might actually be eradicating the very solutions to the medical problems we’re working so hard to solve.

The profound psychological benefits of play are integral to healthy cultures, communities, and individuals, including a direct relationship to work productivity. Engage in some unstructured outdoor physical exertion each day to counter the negative effects of a sedentary, technological existence.

Like the master score of a bewitchingly complex symphonic work, the genome contains the instructions for the development and maintenance of organisms. But the genomic "score" is inert without proteins. Proteins actualize this information. They conduct the genome, thereby playing out its music-activating the viola at the fourteenth minute, a crash of cymbals during the arpeggio, a roll of drums at the crescendo.

Your people give their days (and sometimes their nights) to you. They give their hands, brains, and hearts. Sure, the company pays them. It fills their wallets. But as a leader, you need to fill their souls. You can do that by getting in their skin, by giving the work meaning, by clearing obstacles, and by demonstrating the generosity gene. And you can do it, perhaps most powerfully, by creating an environment that’s exciting and enjoyable.

I turned with an inward groan to look at him. Quackenbush wasn't going to let me just do the work for him like the automaton I wished to be. We were going to have to be pitted against each other. It was easy enough now to see why. For Quackenbush had been systematically disliked since he first set foot in Devon, with careless, disinterested insults coming at him from the beginning, voting for and applauding the class leaders through years of attaining nothing he wanted for himself. I didn't want to add to his humiliations; I even sympathized with his trembling, goaded egotism he could no longer contain, the furious arrogance which sprang out now at the mere hint of opposition from someone he had at last found whom he could consider inferior to himself. I realized that all this explained him, and it wasn't the words he said which angered me. It was only that he was so ignorant, that he knew nothing of the gypsy summer, nothing of the loss I was fighting to endure, of skylarks and splashes and petal-bearing breezes, he had not seen Leper's snails or the Charter of the Super Suicide Society; he shared nothing, knew nothing, felt nothing as Phineas had done.

The Reformation may have resulted in a “Protestant work ethic,” but this was not due to the pressure to prove one’s election by worldly success, as certain social scientists ludicrously maintain. Rather, the work ethic emerged out of an understanding of the meaning of work and the satisfaction and fulfillment that come from ordinary human labor when seen through the light of the doctrine of vocation.

There is one final point, the point that separates a true multivolume work from a short story, a novel, or a series. The ending of the final volume should leave the reader with the feeling that he has gone through the defining circumstances of Main Character's life. The leading character in a series can wander off into another book and a new adventure better even than this one. Main Character cannot, at the end of your multivolume work. (Or at least, it should seem so.) His life may continue, and in most cases it will. He may or may not live happily ever after. But the problems he will face in the future will not be as important to him or to us, nor the summers as golden.

Had I life to live over, I see now where I could do more; but neighbour, believe me, my highest aspiration is to be a clean, thrifty housekeeper, a bountiful cook, a faithful wife, a sympathetic mother. That is life work for any woman, and to be a good woman is the greatest thing on earth. Never mind about the ladies; if you can honestly say of me, she is a good woman, you have paid me the highest possible tribute.

Lots of work has examined the genes involved, most broadly showing that variants that produce lowered dopamine signaling (less dopamine in the synapse, fewer dopamine receptors, or lower responsiveness of these receptors) are associated with sensation seeking, risk taking, attentional problems, and extroversion. Such individuals have to seek experiences of greater intensity to compensate for the blunted dopamine signaling.

People who are depressed at the thought that all our motives are selfish are [confused]. They have mixed up ultimate causation (why something evolved by natural selection) with proximate causation (how the entity works here and now). [A] good way to understand the logic of natural selection is to imagine that genes are agents with selfish motives. [T]he genes have metaphorical motives — making copies of themselves — and the organisms they design have real motives. But they are not the same motives. Sometimes the most selfish thing a gene can do is wire unselfish motives into a human brain — heartfelt, unstinting, deep-in-the-marrow unselfishness. The love of children (who carry one's genes into posterity), a faithful spouse (whose genetic fate is identical to one's own), and friends and allies (who trust you if you're trustworthy) can be bottomless and unimpeachable as far as we humans are concerned (proximate level), even if it is metaphorically self-serving as far as the genes are concerned (ultimate level). Combine this with the common misconception that the genes are a kind of essence or core of the person, and you get a mongrel of Dawkins and Freud: the idea that the metaphorical motives of the genes are the deep, unconscious, ulterior motives of the person. That is an error.

I could have made analytical comparisons with kisses I’d had from other boys, trying to work out just why Gideon did it so much better. I might also have stopped to remember that there was a wall between us, and a confessional window through which Gideon had squeezed his head and arms, and these were not the ideal conditions for kissing. Quite apart from the fact that I could do without any more chaos in my life, after discovering only two days ago that I’d inherited my family’s time-traveling gene. The fact was, however, that I hadn’t been thinking anything at all, except maybe oh and hmm and more! That’s why I hadn’t noticed the flip-flop sensation inside me, and only new, when the little gargoyle folded his arms and flashed his eyes at me from his pew, only when I saw the confessional curtain—brown, although it had been green velvet a moment ago—did I work it out that meanwhile we’d traveled back to the present. “Hell!” Gideon moved back to his side of the confessional and rubbed the back of his head. Hell? I came down from cloud nine with a bump and forgot the gargoyle. “Oh, I didn’t think it was that bad,” I said, trying to sound as casual as possible. Unfortunately, I was rather breathless, which tended to spoil the effect. I couldn’t look Gideon in the eye, so instead I kept staring at the brown polyester curtain in the confessional.

As a working definition of art, I lean toward Tolstoy's: "Art is a human activity having for it's purpose the transmission to other of the highest and best feelings to which mankind has risen." It seems to me that, regarding agrarian art, the farther it moves away from the natural world, especially when the main goal is money profits, the more difficult it becomes for it to reflect "the highest and best feelings" of humanity. The same is true of, of course, of agriculture itself. The farther it tries to remove itself from nature in search of money, the more it moves away from the highest and healthiest kinds of food.

A genius must sometimes be a racist if we are to hope for elucidation. History is generously peppered with geniuses who despised the Jews, who dismissed the blacks, who objectified women. Are we to bury their great works because of this? The answer is a resounding no, we are not to. We are, all of us, human. We are, all of us, imperfect. Prejudice is evolutionarily implanted in our genes. We need to know The Tiger is a dangerous animal. We need not know that all tigers are not. Identifying the personalities of individual tigers does not serve our need to survive. Granted, it might make us more enlightened individuals and friends with some tigers, and I am all for that. I applaud that, but one must recognize that there is a tribal instinct in humans and it is at its base an instinct for survival. So accept that, mourn it, decry it, rail against it, but recognize it is a very human trait and have patience with it. Have compassion. Thank you and good night.

When we learn, we alter which genes in our neurons are “expressed,” or turned on. Our genes have two functions. The first, the “template function,” allows our genes to replicate, making copies of themselves that are passed from generation to generation. The template function is beyond our control. The second is the “transcription function.” Each cell in our body contains all our genes, but not all those genes are turned on, or expressed. When a gene is turned on, it makes a new protein that alters the structure and function of the cell. This is called the transcription function because when the gene is turned on, information about how to make these proteins is “transcribed” or read from the individual gene. This transcription function is influenced by what we do and think. Most people assume that our genes shape us—our behavior and our brain anatomy. Kandel’s work shows that when we learn our minds also, affect which genes in our neurons are transcribed. Thus we can shape our genes, which in turn shape our brain’s microscopic anatomy.

Rather, the doctrine of vocation encourages attention to each individual’s uniqueness, talents, and personality. These are valued as gifts of God, who creates and equips each person in a different way for the calling He has in mind for that person’s life. The doctrine of vocation undermines conformity, recognizes the unique value of every person, and celebrates human differences; but it sets these individuals into a community with other individuals, avoiding the privatizing, self-centered narcissism of secular individualism.

We want to eliminate suffering, but we also want to “keep those sufferings.” It is easy to understand Susan Sontag’s formulation of illness as the “night-side of life.” That conception works for many forms of illness—but not all. The difficulty lies in defining where twilight ends or where daybreak begins. It does not help that the very definition of illness in one circumstance becomes the definition of exceptional ability in another. Night on one side of the globe is often day, resplendent and glorious, on a different continent.

Luther goes so far as to say that vocation is a mask of God. That is, God hides Himself in the workplace, the family, the Church, and the seemingly secular society. To speak of God being hidden is a way of describing His presence, as when a child hiding in the room is there, just not seen. To realize that the mundane activities that take up most of our lives—going to work, taking the kids to soccer practice, picking up a few things at the store, going to church—are hiding-places for God can be a revelation in itself. Most people seek God in mystical experiences, spectacular miracles, and extraordinary acts they have to do. To find Him in vocation brings Him, literally, down to earth, makes us see how close He really is to us, and transfigures everyday life.

Bethesda … Would I be wrong in guessing you work for Uncle Sam?" "Why, yes. You must be very familiar with Washington, Mr. Fenton. Does your work bring you there often?" Anywhere but on our sandbar the little ploy would have worked. My hunter's gene twitches. "Which agency are you with?" She gives up gracefully. "Oh, just GSA records. I'm a librarian." Of course. I know her now, all the Mrs. Parsonses in records divisions, accounting sections, research branches, personnel and administration offices. Tell Mrs. Parsons we need a recap on the external service contracts for fiscal '73. - 'The Women Men Don't See

1. a.Never throw shit at an armed man. b.Never stand next to someone who is throwing shit at an armed man. 2.Never fire a laser at a mirror. 3.Mother Nature doesn't care if you're having fun. 4.F × S = k. The product of Freedom and Security is a constant. To gain more freedom of thought and/or action, you must give up some security, and vice versa. 5.Psi and/or magical powers, if real, are nearly useless. 6.It is easier to destroy than create. 7.Any damn fool can predict the past. 8.History never repeats itself. 9.Ethics change with technology. 10.There Ain't No Justice. (often abbreviated to TANJ) 11.Anarchy is the least stable of social structures. It falls apart at a touch. 12.There is a time and place for tact. And there are times when tact is entirely misplaced. 13.The ways of being human are bounded but infinite. 14.The world's dullest subjects, in order: a.Somebody else's diet. b.How to make money for a worthy cause. c.The Kardashians. 15.The only universal message in science fiction: There exist minds that think as well as you do, but differently. Niven's corollary: The gene-tampered turkey you're talking to isn't necessarily one of them. 16.Fuzzy Pink Niven's Law: Never waste calories. 17.There is no cause so right that one cannot find a fool following it. in variant form in Fallen Angels as "Niven's Law: No cause is so noble that it won't attract fuggheads." 18.No technique works if it isn't used. 19.Not responsible for advice not taken. 20.Old age is not for sissies.

The first school shooting that attracted the attention of a horrified nation occurred on March 24, 1998, in Jonesboro, Arkansas. Two boys opened fire on a schoolyard full of girls, killing four and one female teacher. In the wake of what came to be called the Jonesboro massacre, violence experts in media and academia sought to explain what others called “inexplicable.” For example, in a front-page Boston Globe story three days after the tragedy, David Kennedy from Harvard University was quoted as saying that these were “peculiar, horrible acts that can’t easily be explained.” Perhaps not. But there is a framework of explanation that goes much further than most of those routinely offered. It does not involve some incomprehensible, mysterious force. It is so straightforward that some might (incorrectly) dismiss it as unworthy of mention. Even after a string of school shootings by (mostly white) boys over the past decade, few Americans seem willing to face the fact that interpersonal violence—whether the victims are female or male—is a deeply gendered phenomenon. Obviously both sexes are victimized. But one sex is the perpetrator in the overwhelming majority of cases. So while the mainstream media provided us with tortured explanations for the Jonesboro tragedy that ranged from supernatural “evil” to the presence of guns in the southern tradition, arguably the most important story was overlooked. The Jonesboro massacre was in fact a gender crime. The shooters were boys, the victims girls. With the exception of a handful of op-ed pieces and a smattering of quotes from feminist academics in mainstream publications, most of the coverage of Jonesboro omitted in-depth discussion of one of the crucial facts of the tragedy. The older of the two boys reportedly acknowledged that the killings were an act of revenge he had dreamed up after having been rejected by a girl. This is the prototypical reason why adult men murder their wives. If a woman is going to be murdered by her male partner, the time she is most vulnerable is after she leaves him. Why wasn’t all of this widely discussed on television and in print in the days and weeks after the horrific shooting? The gender crime aspect of the Jonesboro tragedy was discussed in feminist publications and on the Internet, but was largely absent from mainstream media conversation. If it had been part of the discussion, average Americans might have been forced to acknowledge what people in the battered women’s movement have known for years—that our high rates of domestic and sexual violence are caused not by something in the water (or the gene pool), but by some of the contradictory and dysfunctional ways our culture defines “manhood.” For decades, battered women’s advocates and people who work with men who batter have warned us about the alarming number of boys who continue to use controlling and abusive behaviors in their relations with girls and women. Jonesboro was not so much a radical deviation from the norm—although the shooters were very young—as it was melodramatic evidence of the depth of the problem. It was not something about being kids in today’s society that caused a couple of young teenagers to put on camouflage outfits, go into the woods with loaded .22 rifles, pull a fire alarm, and then open fire on a crowd of helpless girls (and a few boys) who came running out into the playground. This was an act of premeditated mass murder. Kids didn’t do it. Boys did.

There is also a psychological phenomenon at work here that I believe is particularly male. A woman or girl--presuming one could be induced to take part in this sort of activity in the first place--having burned her hair and eyebrows would conclude that she had been lucky and reduce the amount of gas she put into the balloon next time. The man doesn't come to the same conclusion at all. He, singed and blackened, arrives at the point of view that he still has a margin of error to play with. After all, he isn't dead, and he's hardly likely to burn his eyebrows off again. They've already gone, history; he's moved on. There can be but one deduction--the dose needs to be increased.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

When we combine the adaptation principle with the discovery that people’s average level of happiness is highly heritable,11 we come to a startling possibility: In the long run, it doesn’t much matter what happens to you. Good fortune or bad, you will always return to your happiness setpoint—your brain’s default level of happiness—which was determined largely by your genes. In 1759, long before anyone knew about genes, Adam Smith reached the same conclusion: In every permanent situation, where there is no expectation of change, the mind of every man, in a longer or shorter time, returns to its natural and usual state of tranquility. In prosperity, after a certain time, it falls back to that state; in adversity, after a certain time, it rises up to it.12 If this idea is correct, then we are all stuck on what has been called the “hedonic treadmill.”13 On an exercise treadmill you can increase the speed all you want, but you stay in the same place. In life, you can work as hard as you want, and accumulate all the riches, fruit trees, and concubines you want, but you can’t get ahead. Because you can’t change your “natural and usual state of tranquility,” the riches you accumulate will just raise your expectations and leave you no better off than you were before. Yet, not realizing the futility of our efforts, we continue to strive, all the while doing things that help us win at the game of life. Always wanting more than we have, we run and run and run, like hamsters on a wheel.

Although the idea has been around for ages, most depressed people do not really comprehend it. If you feel depressed, you may think it is because of bad things that have happened to you. You may think you are inferior and destined to be unhappy because you failed in your work or were rejected by someone you loved. You may think your feelings of inadequacy result from some personal defect—you may feel convinced you are not smart enough, successful enough, attractive enough, or talented enough to feel happy and fulfilled. You may think your negative feelings are the result of an unloving or traumatic childhood, or bad genes you inherited, or a chemical or hormonal imbalance of some type. Or you may blame others when you get upset: “It’s these lousy stupid drivers that tick me off when I drive to work! If it weren’t for these jerks, I’d be having a perfect day!” And nearly all depressed people are convinced that they are facing some special, awful truth about themselves and the world and that their terrible feelings are absolutely realistic and inevitable. Certainly all these ideas contain an important gem of truth—bad things do happen, and life beats up on most of us at times. Many people do experience catastrophic losses and confront devastating personal problems. Our genes, hormones, and childhood experiences probably do have an impact on how we think and feel. And other people can be annoying, cruel, or thoughtless. But all these theories about the causes of our bad moods have the tendency to make us victims—because we think the causes result from something beyond our control. After all, there is little we can do to change the way people drive at rush hour, or the way we were treated when we were young, or our genes or body chemistry (save taking a pill). In contrast, you can learn to change the way you think about things, and you can also change your basic values and beliefs. And when you do, you will often experience profound and lasting changes in your mood, outlook, and productivity. That, in a nutshell, is what cognitive therapy is all about. The theory is straightforward

I once read a theory about ‘positive thinking’ that seems to be true or, at least, made a sufficient impression on me to remember it. I have always been distrustful of positive thinking, believing it to be as fixed and unyielding as negative thinking. Yet it is the advice most often offered to depressives. That it does not work seems not to occur to those who offer it up like some benevolent panacea. Perhaps it works for them or perhaps they are a product of some positive thinking gene pool. Who knows? Anywhere, here is the theory that helped me. I hope that it will help you too. Imagine you are driving a car, and you are heading straight for a brick wall. If you stay in habitual or rigid thinking (the kind of thinking that says, ‘this is the way I always do things’) and do not change the direction in the way you are headed, you will drive you car into the brick wall. Now imagine you are driving that same car towards that same brick wall. Now use positive thinking to imagine that wall is, in fact, a tunnel. It is not, of course, you simply hope or wish that it is a tunnel but it is the same old, intractable brick. You still drive your car into the wall. You are in the same car, facing the same wall except that you use creative or constructive thinking. You see the wall as an obstacle set dead ahead and see that it is solid and immoveable. You use your thinking to change direction and drive your car around it. Understanding that our thinking is not always helpful sounds so obvious and simple. So does changing our thinking, yet both are formidably difficult to do, perhaps because, most of the time, we never question it. We go right ahead and do what we have always done, in the same way we have always done it. We crash into relationships, mess up jobs, ruin friendships and all because we believe that our way is the right way. There is a saying: ‘I’d rather be right than happy.’ And here is another: ‘My way or no way.’ I see that wall as a symbol for an obstacle (or obstacles, there may be many) in our emotional make-up. If we go on behaving in the same way, we will crash. If we pretend that those obstacles in our character don’t exist, or are something else entirely, we will still crash. But if we acknowledge them and behave in a different way, we will come to a better and safer place. Or at least we will, until we meet the next obstacle.

This has been a book about people trying to solve problems created by people trying to solve problems. In the course of reporting it, I spoke to engineers and genetic engineers, biologists and microbiologists, atmospheric scientists and atmospheric entrepreneurs. Without exception, they were enthusiastic about their work. But, as a rule, this enthusiasm was tempered by doubt. The electric fish barriers, the concrete crevasse, the fake cavern, the synthetic clouds- these were presented to me less in a spirit of techno-optimism than what might be called techno-fatalism. They weren't improvements on the originals; they were the best that anyone could come up with, given the circumstances... It's in this context that interventions like assisted evolution and gene drives and digging millions of trenches to bury billions of trees have to be assessed. Geoengineering may be 'entirely crazy and quite disconcerting', but if it could slow the melting of the Greenland ice sheet, or take some of 'the pain and suffering away', or help prevent no-longer-fully-natural ecosystems from collapsing, doesn't it have to be considered?

But I don't know, Wesley. This thing makes me think, too. S'pose we'd got Elnora when she was a baby, and we'd heaped on her all the love we can't on our own, and we'd coddled, petted, and shielded her, would she have made the woman that living alone, learning to think for herself, and taking all the knocks Kate Comstock could give, have made of her?" "You bet your life!" cried Wesley, warmly. "Loving anybody don't hurt them. We wouldn't have done anything but love her. You can't hurt a child loving it. She'd have learned to work, be sensible, study, and grown into a woman with us, without suffering like a poor homeless dog." "But you don't get the point, Wesley. She would have grown into a fine woman with us; just seems as if Elnora was born to be fine, but as we would have raised her, would her heart ever have known the world as it does now? Where's the anguish, Wesley, that child can't comprehend? Seeing what she's seen of her mother hasn't hardened her. She can understand any mother's sorrow. Living life from the rough side has only broadened her. Where's the girl or boy burning with shame, or struggling to find a way, that will cross Elnora's path and not get a lift from her? She's had the knocks, but there'll never be any of the thing you call 'false pride' in her. I guess we better keep out. Maybe Kate Comstock knows what she's doing. Sure as you live, Elnora has grown bigger on knocks than she would on love.

Exploring Self-Compassion Through Letter Writing PART ONE Everybody has something about themselves that they don’t like; something that causes them to feel shame, to feel insecure or not “good enough.” It is the human condition to be imperfect, and feelings of failure and inadequacy are part of the experience of living. Try thinking about an issue that tends to make you feel inadequate or bad about yourself (physical appearance, work or relationship issues, etc.). How does this aspect of yourself make you feel inside—scared, sad, depressed, insecure, angry? What emotions come up for you when you think about this aspect of yourself? Please try to be as emotionally honest as possible and to avoid repressing any feelings, while at the same time not being melodramatic. Try to just feel your emotions exactly as they are—no more, no less. PART TWO Now think about an imaginary friend who is unconditionally loving, accepting, kind, and compassionate. Imagine that this friend can see all your strengths and all your weaknesses, including the aspect of yourself you have just been thinking about. Reflect upon what this friend feels toward you, and how you are loved and accepted exactly as you are, with all your very human imperfections. This friend recognizes the limits of human nature and is kind and forgiving toward you. In his/her great wisdom this friend understands your life history and the millions of things that have happened in your life to create you as you are in this moment. Your particular inadequacy is connected to so many things you didn’t necessarily choose: your genes, your family history, life circumstances—things that were outside of your control. Write a letter to yourself from the perspective of this imaginary friend—focusing on the perceived inadequacy you tend to judge yourself for. What would this friend say to you about your “flaw” from the perspective of unlimited compassion? How would this friend convey the deep compassion he/she feels for you, especially for the discomfort you feel when you judge yourself so harshly? What would this friend write in order to remind you that you are only human, that all people have both strengths and weaknesses? And if you think this friend would suggest possible changes you should make, how would these suggestions embody feelings of unconditional understanding and compassion? As you write to yourself from the perspective of this imaginary friend, try to infuse your letter with a strong sense of the person’s acceptance, kindness, caring, and desire for your health and happiness. After writing the letter, put it down for a little while. Then come back and read it again, really letting the words sink in. Feel the compassion as it pours into you, soothing and comforting you like a cool breeze on a hot day. Love, connection, and acceptance are your birthright. To claim them you need only look within yourself.

These computer simulations try only to duplicate the interactions between the cortex and the thalamus. Huge chunks of the brain are therefore missing. Dr. [Dharmendra] Modha understands the enormity of his project. His ambitious research has allowed him to estimate what it would take to create a working model of the entire human brain, and not just a portion or a pale version of it, complete with all parts of the neocortex and connections to the senses. He envisions using not just a single Blue Gene computer [with over a hundred thousand processors and terabytes of RAM] but thousands of them, which would fill up not just a room but an entire city block. The energy consumption would be so great that you would need a thousand-megawatt nuclear power plant to generate all the electricity. And then, to cool off this monstrous computer so it wouldn't melt, you would need to divert a river and send it through the computer circuits. It is remarkable that a gigantic, city-size computer is required to simulate a piece of human tissue that weighs three pounds, fits inside your skull, raises your body temperature by only a few degrees, uses twenty watts of power, and needs only a few hamburgers to keep it going.

Psychologists often approach personality by measuring basic traits such as the “big five”: neuroticism, extroversion, openness to new experiences, agreeableness (warmth/niceness), and conscientiousness.15 These traits are facts about the elephant, about a person’s automatic reactions to various situations. They are fairly similar between identical twins reared apart, indicating that they are influenced in part by genes, although they are also influenced by changes in the conditions of one’s life or the roles one plays, such as becoming a parent.16 But psychologist Dan McAdams has suggested that personality really has three levels... The third level of personality is that of the “life story.” Human beings in every culture are fascinated by stories; we create them wherever we can. (See those seven stars up there? They are seven sisters who once . . . ) It’s no different with our own lives. We can’t stop ourselves from creating what McAdams describes as an “evolving story that integrates a reconstructed past, perceived present, and anticipated future into a coherent and vitalizing life myth.”18 Although the lowest level of personality is mostly about the elephant, the life story is written primarily by the rider. You create your story in consciousness as you interpret your own behavior, and as you listen to other people’s thoughts about you. The life story is not the work of a historian—remember that the rider has no access to the real causes of your behavior; it is more like a work of historical fiction that makes plenty of references to real events and connects them by dramatizations and interpretations that might or might not be true to the spirit of what happened. Adversity may be necessary for growth because it forces you to stop speeding along the road of life, allowing you to notice the paths that were branching off all along, and to think about where you really want to end up.

Sitting here in my lab, I can imagine you scratching your head again: Dr. Panda, what’s the big deal? Aren’t we talking about just a few ounces of fat gain after a late-night snack? Won’t my metabolic rhythm come back the next day? Actually, it’s worse than you think. It is hard enough for the body to monitor hormones, genes, and clocks for someone with a strict eating routine. But when eating occurs at random times throughout the day and night, the fat-making process stays on all the time. At the same time, glucose created from digested carbohydrates floods our blood and the liver becomes inefficient in its ability to absorb glucose. If this continues for a few days, blood glucose continues to rise and reaches the danger zone of prediabetes or diabetes. So, if you’ve wondered why diets haven’t worked for you before, timing might be the reason. Even if you were diligently exercising; counting calories; avoiding fats, carbs, and sweets; and piling on the protein, it’s quite likely that you weren’t respecting your circadian clocks. If you eat late at night or start breakfast at a wildly different time each morning, you are constantly throwing your body out of sync. Don’t worry, the fix is equally simple: Just set an eating routine and stick to it. Timing is everything.

For evolution to be true, there would have been innumerable transitional forms between different types of creatures. Therefore, for every known fossil species, many more must have existed to connect it to its ancestors and descendents [sic]. This is yet another example of evolutionary conclusions coming before the evidence. Really, the claim is an implicit admission that large numbers of transitional forms are predicted, which heightens the difficulty for evolutionists, given how few there are that even they could begin to claim were candidates. . . . Evolutionists believe that mutation provides new information for selection. But no known mutation has ever increased genetic information, although there should be many examples observable today if mutation/selection were truly adequate to explain the goo-to-you theory. . . . Adaptation and natural selection are biological facts; amoeba-to-man evolution is not. Natural selection can only work on the genetic information present in a population of organisms--it cannot create new information. For example, since no known reptiles have genes for feathers, no amount of selection will produce a feathered reptile. Mutations in genes can only modify or eliminate existing structures, not create new ones. If in a certain environment a lizard survives better with smaller legs, or no legs, then varieties with this trait will be selected for. This might more accurately be called devolution, not evolution. . . . Note that even if such a mutation were ever discovered, evolutionists would still need to find hundreds more to give their theory the observational boost it desperately needs.

M-m-master, when I was on the Quasar I had a paracoita, a doll, you see, a genicon, so beautiful with her great pupils as dark as wells, her i-irises purple like asters or pansies blooming in summer, Master, whole beds of them, I thought, had b-been gathered to make those eyes, that flesh that always felt sun-warmed. Wh-wh-where is she now, my own scopolagna, my poppet? Let h-h-hooks be buried in the hands that took her! Crush them, master, beneath stones. Where has she gone from the lemon-wood box I made for her, where she never slept at all, for she lay with me all night, not in the box, the lemon-wood box where she waited all day, watch-and-watch, Master, smiling when I laid her in so she might smile when I drew her out. How soft her hands were, her little hands. Like d-d-doves. She might have flown with them about the cabin had she not chosen instead to lie with me. W-w-wind their guts about your w-windlass, snuff their eyes into their mouths. Unman them, shave them clean below so their doxies may not know them, their lemans may rebuke them, leave them to the brazen laughter of the brazen mouths of st-st-strumpets. Work your will upon those guilty. Where was their mercy on the innocent? When did they tremble, when weep? What kind of men could do as they have done—thieves, false friends, betrayers, bad shipmates, no shipmates, murderers and kidnappers. W-without you, where are their nightmares, where are their restitutions, so long promised? Where are their abacinations, that shall leave them blind? Where are the defenestrations that shall break their bones, where is the estrapade that shall grind their joints? Where is she, the beloved whom I lost?

One," said the recording secretary. "Jesus wept," answered Leon promptly. There was not a sound in the church. You could almost hear the butterflies pass. Father looked down and laid his lower lip in folds with his fingers, like he did sometimes when it wouldn't behave to suit him. "Two," said the secretary after just a breath of pause. Leon looked over the congregation easily and then fastened his eyes on Abram Saunders, the father of Absalom, and said reprovingly: "Give not sleep to thine eyes nor slumber to thine eyelids." Abram straightened up suddenly and blinked in astonishment, while father held fast to his lip. "Three," called the secretary hurriedly. Leon shifted his gaze to Betsy Alton, who hadn't spoken to her next door neighbour in five years. "Hatred stirreth up strife," he told her softly, "but love covereth all sins." Things were so quiet it seemed as if the air would snap. "Four." The mild blue eyes travelled back to the men's side and settled on Isaac Thomas, a man too lazy to plow and sow land his father had left him. They were not so mild, and the voice was touched with command: "Go to the ant, thou sluggard, consider her ways and be wise." Still that silence. "Five," said the secretary hurriedly, as if he wished it were over. Back came the eyes to the women's side and past all question looked straight at Hannah Dover. "As a jewel of gold in a swine's snout, so is a fair woman without discretion." "Six," said the secretary and looked appealingly at father, whose face was filled with dismay. Again Leon's eyes crossed the aisle and he looked directly at the man whom everybody in the community called "Stiff-necked Johnny." I think he was rather proud of it, he worked so hard to keep them doing it. "Lift not up your horn on high: speak not with a stiff neck," Leon commanded him. Toward the door some one tittered. "Seven," called the secretary hastily. Leon glanced around the room. "But how good and how pleasant it is for brethren to dwell together in unity," he announced in delighted tones as if he had found it out by himself. "Eight," called the secretary with something like a breath of relief. Our angel boy never had looked so angelic, and he was beaming on the Princess. "Thou art all fair, my love; there is no spot in thee," he told her. Laddie would thrash him for that. Instantly after, "Nine," he recited straight at Laddie: "I made a covenant with mine eyes; why then should I think upon a maid?" More than one giggled that time. "Ten!" came almost sharply. Leon looked scared for the first time. He actually seemed to shiver. Maybe he realized at last that it was a pretty serious thing he was doing. When he spoke he said these words in the most surprised voice you ever heard: "I was almost in all evil in the midst of the congregation and assembly." "Eleven." Perhaps these words are in the Bible. They are not there to read the way Leon repeated them, for he put a short pause after the first name, and he glanced toward our father: "Jesus Christ, the SAME, yesterday, and to-day, and forever!" Sure as you live my mother's shoulders shook. "Twelve." Suddenly Leon seemed to be forsaken. He surely shrank in size and appeared abused. "When my father and my mother forsake me, then the Lord will take me up," he announced, and looked as happy over the ending as he had seemed forlorn at the beginning. "Thirteen." "The Lord is on my side; I will not fear; what can man do unto me?" inquired Leon of every one in the church. Then he soberly made a bow and walked to his seat.

The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. When I started my research, sirtuins were barely on the scientific radar. Now this family of genes is at the forefront of medical research and drug development. Descended from gene B in M. superstes, sirtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.

Given that the historically most violent regions of the UK had virtually no black population at all and given that working-class youth gangs stabbing and shooting people had existed in Britain for well over a century - who do you think the gangs attacking our grandparents when they arrived were? - you can imagine my shock when I discovered that there was, in the UK, such a thing as ‘black-on-black’ violence. None of what occurred in Northern Ireland had ever been referred to as ‘white-on-white’ crime, nor Glasgow, nor either world war, the Seven Years War, the Napoleonic Wars, nor any conflict or incident of murder, however gruesome, between humans racialised as white. Despite hundreds of millions of ‘white’ people killing each other throughout European history, witch hunts, mass rapes, hangings, torture and sexual abuse, and despite the fact that the two most violent regions of Britain in the 1990s were almost entirely white, there was no such thing as white-on-white violence. Yet apparently working-class black Londoners had imported from America a rap-induced mystery nigger gene (similar to the slave sprint one?) that caused black people to kill not for all of the complex reasons that other humans kill, but simply because they are ‘black’, and sometimes because they listened to too much rap, grime or dancehall. This is, after all, what the phrase ‘black-on-black crime’ is designed to suggest, is it not? That black people are not like the rest of humanity, and that they do not kill as a complex result of political, historical, economic, cultural, religious and psychological factors, they kill simply because of their skin: their excessive melanin syndrome. The fact that yellow-on-yellow crime, mixed race-on-mixed race crime or white-on-white violence just sound like joke terms but black on black violence has ‘credibility’ speaks very loudly about the perceived relationship between blackness and depravity in this culture.

The Swedish town of Överkalix has the most comprehensive and oldest birth, death, and crop records in the world. Their records go back generations—a remarkably rich data set. And in analyzing this data set, scientists found some fascinating correlations. There were good and bad years for the crops in Överkalix and some particularly bad years where families were forced to go hungry. But scientists discovered that when children suffered starvation between the ages of nine and twelve, their grandchildren would on average live thirty years longer. Their descendants had far lower rates of diabetes and heart disease. On the other hand, when children were well-fed during those ages, their descendants were at four times the risk for heart attacks and their life expectancy dropped. In some strange way, the trauma of starvation changed descendants’ genes to be more resilient. Healthier. More likely to survive.[5] — Clearly, it wasn’t just my ruthless nurture that had shaped me into who I was, though who knows what kind of rampant methylation savaged my epigenome during my beatings and assaults. Beyond that, every cell in my body is filled with the code of generations of trauma, of death, of birth, of migration, of history that I cannot understand. Just piecemeal moments I collected from Auntie over the years. My family tried to erase this history. But my body remembers. My work ethic. My fear of cockroaches. My hatred for the taste of dirt. These are not random attributes, a spin of the wheel. They were gifted to me with purpose, with necessity. I want to have words for what my bones know. I want to use those gifts when they serve me and understand and forgive them when they do not.

When I interviewed with the Chief of Family Medicine at a large medical corporation on the West Coast, he explained that, since he was part of a team of people who arranged for pharmaceutical companies to issue cash grants, he was in a position to offer me a particularly enticing salary. “What are the grants for?” I asked. “We have a quality improvement program that tracks physician prescribing patterns. We call it ‘quality’ but it’s really about money.” And that’s all it’s about. It works like this. In his organization, any patient with LDL cholesterol over 100 is put on a cholesterol-lowering medication. Any person with a blood pressure higher than 140/90 is put on a blood pressure medication. Any person with “low bone density” is put on a bone-remodeling inhibitor. And so on. The doctors who prescribe the most get big bonuses. Those who prescribe the least get fired. With a hint of incredulousness in his voice, he explained, “So far, every time we’ve asked for funding for our program, the drug companies give it to us.” If this is where healthcare is headed, then these hybrid physicians-executives will instinctively turn their gaze to our children and invent more creative methods to bulldoze an entire generation into the bottomless pit of chronic disease.

Jack coughed slightly and offered his hand. “Hi, uh. I’m Jack.” Kim took it. “Jack what?” “Huh?” “Your last name, silly.” “Jackson.” She blinked at him. “Your name is Jack Jackson?” He blushed. “No, uh, my first name’s Rhett, but I hate it, so…” He gestured to the chair and she sat. Her dress rode up several inches, exposing pleasing long lines of creamy skin. “Well, Jack, what’s your field of study?” “Biological Engineering, Genetics, and Microbiology. Post-doc. I’m working on a research project at the institute.” “Really? Oh, uh, my apple martini’s getting a little low.” “I’ve got that, one second.” He scurried to the bar and bought her a fresh one. She sipped and managed to make it look not only seductive but graceful as well. “What do you want to do after you’re done with the project?” Kim continued. “Depends on what I find.” She sent him a simmering smile. “What are you looking for?” Immediately, Jack’s eyes lit up and his posture straightened. “I started the project with the intention of learning how to increase the reproduction of certain endangered species. I had interest in the idea of cloning, but it proved too difficult based on the research I compiled, so I went into animal genetics and cellular biology. It turns out the animals with the best potential to combine genes were reptiles because their ability to lay eggs was a smoother transition into combining the cells to create a new species, or one with a similar ancestry that could hopefully lead to rebuilding extinct animals via surrogate birth or in-vitro fertilization. We’re on the edge of breaking that code, and if we do, it would mean that we could engineer all kinds of life and reverse what damage we’ve done to the planet’s ecosystem.” Kim stared. “Right. Would you excuse me for a second?” She wiggled off back to her pack of friends by the bar. Judging by the sniggering and the disgusted glances he was getting, she wasn’t coming back. Jack sighed and finished off his beer, massaging his forehead. “Yes, brilliant move. You blinded her with science. Genius, Jack.” He ordered a second one and finished it before he felt smallish hands on his shoulders and a pair of soft lips on his cheek. He turned to find Kamala had returned, her smile unnaturally bright in the black lights glowing over the room. “So…how did it go with Kim?” He shot her a flat look. “You notice the chair is empty.” Kamala groaned. “You talked about the research project, didn’t you?” “No!” She glared at him. “…maybe…” “You’re so useless, Jack.” She paused and then tousled his hair a bit. “Cheer up. The night’s still young. I’m not giving up on you.” He smiled in spite of himself. “Yet.” Her brown eyes flashed. “Never.

Barbara and I had arrived early, so I got to admire everyone’s entrance. We were seated at tables around a dance floor that had been set up on the lawn behind the house. Barbara and I shared a table with Deborah Kerr and her husband. Deborah, a lovely English redhead, had been brought to Hollywood to play opposite Clark Gable in The Hucksters. Louis B. Mayer needed a cool, refined beauty to replace the enormously popular redhead, Greer Garson, who had married a wealthy oil magnate and retired from the screen in the mid-fifties. Deborah, like her predecessor, had an ultra-ladylike air about her that was misleading. In fact, she was quick, sharp, and very funny. She and Barbara got along like old school chums. Jimmy Stewart was also there with his wife. It was the first time I’d seen him since we’d worked for Hitchcock. It was a treat talking to him, and I felt closer to him than I ever did on the set of Rope. He was so genuinely happy for my success in Strangers on a Train that I was quite moved. Clark Gable arrived late, and it was a star entrance to remember. He stopped for a moment at the top of the steps that led down to the garden. He was alone, tanned, and wearing a white suit. He radiated charisma. He really was the King. The party was elegant. Hot Polynesian hors d’oeuvres were passed around during drinks. Dinner was very French, with consommé madrilène as a first course followed by cold poached salmon and asparagus hollandaise. During dessert, a lemon soufflé, and coffee, the cocktail pianist by the pool, who had been playing through dinner, was discreetly augmented by a rhythm section, and they became a small combo for dancing. The dance floor was set up on the lawn near an open bar, and the whole garden glowed with colored paper lanterns. Later in the evening, I managed a subdued jitterbug with Deborah Kerr, who was much livelier than her cool on-screen image. She had not yet done From Here to Eternity, in which she and Burt Lancaster steamed up the screen with their love scene in the surf. I was, of course, extremely impressed to be there with Hollywood royalty that evening, but as far as parties go, I realized that I had a lot more fun at Gene Kelly’s open houses.