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Since his father’s death in 1464, Piero de’ Medici had done his best to maintain his family’s preeminent position in Florence. According to a chronicler, Piero enjoyed “great authority, many friends, wealth, and a power similar to his father’s.”24 By 1466, however, Piero, at fifty years old, was increasingly disabled by gout. As a result, government meetings and ambassadorial receptions were held not in the Palazzo della Signoria but in the Palazzo Medici, which increasingly served as the seat of government. Moreover, Piero lacked his father’s shrewdness and experience, and his power and grandeur soon provoked indignation among the citizens. His father had faced similar crises due to rivals and malcontents, most recently in 1458. On that occasion, the Medici maintained their power thanks to Cosimo’s longtime ally, the duke of Milan, Francesco Sforza, who sent troops to quell an insurrection. As mercenary troops poured into the city, Cosimo took the opportunity to arrest 150 opponents, torture a few others, and strengthen his grip on power. However, the death of Sforza in March 1466 robbed Piero, so soon after losing his father, of this reliable supplier of military might.
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Ross King (The Bookseller of Florence: The Story of the Manuscripts That Illuminated the Renaissance)