Family Genes Quotes

we are more than just our genes. We are, in some way, a product of the people who surround us—the people we’re forced to grow up with, and the people we choose to be with later.

I was conceived because it would be good for my House to have an heir and because my parents' genes ticked the right set of boxes. You were probably conceived because your parents loved each other." "According to our mother," Bern said, "he was conceived because she was too wasted to remember a rubber." Mad Rogan stopped chewing. "I was conceived because my mother skipped bail. Her boyfriend at the time threatened to call the cops on her so she had to do something to keep him from doing it," Bern said helpfully. Awesome. Just the right kind of information to share. "Aunt Giselea isn't the best mother," I said. "There's one in every family.

Would you have this?” the Protectorat hissed at his son. Rafael's gaze narrowed in a slow inspection while she stared defiantly back. Rafael's gaze faltered, shot briefly toward Leon, and then down. His answer was obvious: no. And in spite of everything, in the face of all the other more important dangers that threatened her, it still stung that someone, some boy, found her ugly. Gaia burned with sudden hate for all of them. The Protectorat saw. He smiled slightly. “I thought not,” said the Protectorat, releasing her with a flick. He turned back toward his family. “I can't thrust her on any family I know, no matter what her genes are. She's a freak, not a hero. I'd rather make a hero out of Myrna Silk.” Leon had been standing tensely throughout this exchange. “I'd take Gaia,” Leon said, his low voice resonating in the space.

The difference between a ‘man’ and a ‘father’ is that the former shares his genes, but latter gives his life.

Genes, I have learned, do not make a family. Families are the people that stick around through good and bad times. Sadness is a part of life. Choosing to be happy and see the glass half full is a struggle we all must make.

Family is in essence a small nation, and the nation a large family. In treating his own family with dignity, a ruler learns to govern his nation with dignity

Luther says that vocations are a “mask from God. That is, God hides Himself in the workplace, the family, the Church, and the seemingly secular society

But what was family? Surely more than genes, eye color, flesh. Family was story: truth and struggle and retribution. Family was time. If he had learned anything it was the family was not so much what you were given as what you were able to maintain.

Family took a lot more than genes to hold it together

Sometimes we encounter men, even entire families, whose gross ignorance, unappealing mien or reckless habits make us wonder how their genes have survived the trials and tribulations of the ages. Yet we do well to remember that, should the world be plunged into nuclear holocaust, the principal candidate for survival is neither man, nor the great elephant, nor the swift stallion, nor the wily fox – it is the lowly cockroach.

Either way, one should love their children, shouldn’t they? After all, children are only duplicates of your own genes. What did these children ever ask for? They wanted love, family, and support. But WE kicked them out onto streets like animals just because WE, as adults, were scared of a situation WE weren’t used to.

Please, this family doesn’t have a tact gene,” she argued. “We’ve got a busybody gene, a cooking gene, a petulant gene. The tact gene just didn’t skip our entire generation; it skipped our entire gene pool.

How’s this for fascinating: Heritability of various aspects of cognitive development is very high (e.g., around 70 percent for IQ) in kids from high–socioeconomic status (SES) families but is only around 10 percent in low-SES kids. Thus, higher SES allows the full range of genetic influences on cognition to flourish, whereas lower-SES settings restrict them. In other words, genes are nearly irrelevant to cognitive development if you’re growing up in awful poverty—poverty’s adverse effects trump the genetics.fn24 Similarly, heritability of alcohol use is lower among religious than nonreligious subjects—i.e., your genes don’t matter much if you’re in a religious environment that condemns drinking. Domains like these showcase the potential power of classical behavior genetics.

Man has made the artificial world in which he lives, but he is clearly not made for it.

Of course you do, child," said mother. "Families were made to cling together, and stand by each other in every circumstance of life—joy or sorrow. Of course you need your family.

Environment does not cause ADD any more than genes cause ADD. What happens is that if certain genetic material meets a certain environment, ADD may result. Without that genetic material, no ADD. Without that environment, no ADD. The formative environment is the family of origin.

If the homemakers of this country don't get the idea into their heads pretty soon that they are not going to be able to hold their own with the rest of the world, with no children, or one child in the family, there's a sad day of reckoning coming.

Aidan pulled away and stared intently at her. His blue eyes blazed with intensity. “Listen to me. You have every right to be scared, but I want you to believe me when I say that Noah is going to be fine. He’s blessed with some strong as hell genes.” Placing his hand on her belly, he smiled. “He’s part Fitzgerald, and for generations, the men of my family have been known for being tough, scrappy fighters with a will of iron to survive.” “Really?” she questioned with a hiccup. Aidan nodded. “But even more than the fighting Irish Fitzgerald blood pumping through him, he’s inherited the most amazing DNA from his mother. She’s the strongest person I’ve ever known.

According to the Reformers, each Christian has multiple vocations. We have callings in our work. We have callings in our families. We have callings as citizens in the larger society. And we have callings in the Church.

Genetically speaking, we are one people. The two most seemingly different people in the world are virtually identical from the point of their genes.φ At most, about one in a thousand nucleotides in our DNA are different between the blackest and the whitest, the tallest and the shortest of us. We are 99.9 percent the same. We are one tribe, one family, but have yet to recognize it. We humans are all intimately interconnected. How we treat each other matters to the health and well-being, perhaps even the survival, of us all as a species, not in some vague future, but in this very moment.

Making Genetic Changes We used to think that genes created disease and that we were at the mercy of our DNA. So if many people in someone’s family died of heart disease, we assumed that their chances of also developing heart disease would be pretty high. But we now know through the science of epigenetics that it’s not the gene that creates disease but the environment that programs our genes to create disease—and not just the external environment outside our body (cigarette smoke or pesticides, for example), but also the internal environment within our body: the environment outside our cells. What do I mean by the environment within our body? As I said previously, emotions are chemical feedback, the end products of experiences we have in our external environment. So as we react to a situation in our external environment that produces an emotion, the resulting internal chemistry can signal our genes to either turn on (up-regulating, or producing an increased expression of the gene) or to turn off (down-regulating, or producing a decreased expression of the gene). The gene itself doesn’t physically change—the expression of the gene changes, and that expression is what matters most because that is what affects our health and our lives.

Despite the fact we give hurricanes names like Katrina and Rita, a hurricane isn't a self-contained unit. A hurricane is an impermanent, ever-changing phenomenon arising out of a particular set of interacting conditions - air pressure, ground temperature, humidity, wind and so on. The same applies to us: we aren't self-contained units either. Like weather patterns, we are also an impermanent, ever-changing phenomenon arising out of a particular set of interacting conditions. Without food, water, air and shelter, we'd be dead. Without our genes, family, friends, social history, and culture, wouldn't act or feel as we do.

Growing up in Fitzgerald, I lived in an intense microcosm, where your neighbor knows what you're going to do even before you do, where you can recognize a family gene pool by the lift of an eyebrow, or the length of a neck, or a way of walking. What is said, what is left to the imagination, what is denied, withheld, exaggerated-all these secretive, inverted things informed my childhood. Writing the stories that I found in the box, I remember being particularly fascinated by secrets kept in order to protect someone from who you are. That protection, sharpest knife in the drawer, I absorbed as naturally as a southern accent. At that time, I was curious to hold up to the light glimpses of the family that I had so efficiently fled. We were remote-back behind nowhere-when I was growing up, but even so, enormous social change was about to crumble foundations. Who were we, way far South? "We're south of everywhere," my mother used to lament.

The uniformity of the earth's life, more astonishing than its diversity, is accountable by the high probability that we derived, originally, from some single cell, fertilized in a bolt of lightning as the earth cooled. It is from the progeny of this parent cell that we take our looks; we still share genes around, and the resemblance of the enzymes of grasses to those of whales is a family resemblance.

none of the ways in which we talk about race today stands up to the scrutiny that genetics has enabled. Families are too untidy, human history is too convoluted, people too motile. The deck has been shuffled and reshuffled. Genetics has shown that people are different, and these differences cluster according to geography and culture, but never in a way that aligns with the traditional concepts of human races.

Nuclear didn't describe families. How could it? Dry physics was not equal to that task. In the twentieth century we needed a biological metaphor, Darwinian in scope, to suggest the gnash and crash of carnivorous life in the family gene pool. But for the 21st century, the new century, I think the metaphors must be chemical. Molecular. In the molecular family people are connected without being bound. They spindle themselves around shared experiences and affections rather than splashing in the shared gene pool.

Anyone who claims that blood is thicker than water, that the ties in a family who share the same genes are stronger, does not understand how love works.

If you want to properly tell a story, you have to be willing to write it a thousand ways. And then you must be brave enough to share it with others.

But Lindsay understood now how we are more than just our genes. We are, in some way, a product of the people who surround us—the people we’re forced to grow up with, and the people we choose to be with later.

Secrets with Laddie were the greatest joy in life. He was so big and so handsome. He was so much nicer than any one else in our family, or among our friends, that to share his secrets, run his errands, and love him blindly was the greatest happiness. Sometimes I disobeyed father and mother; I minded Laddie like his right hand

Since we humans do not want to return to the old selfish ways where we let the children of too-large families starve to death, we have abolished the family as a unit of economic self-sufficiency, and substituted the state.

Your Script Here’s what to tell someone or yourself while you’re feeling hopelessly fucked-up. Dear [Me/Family Member/Fuckup I Can’t Help But Care About], I know you feel like [the royal “we”/you/our fuckup son] is on the verge of [insert mistake or potential tragic experience], and life feels like an unholy disaster. The truth is, however, that life often sucks and sometimes I can’t expect to feel other than [insert classier, more dire synonym for “shitty”], especially given issues in the past regarding [bad luck/anxiety/your many addictions and world-record unemployment]. So don’t take it personally and do take credit for whatever good things you were doing, even if they were totally ineffective at fending off this mess. Take pride in doing a good job, regardless of bad [luck/genes/associates/mental pain] and don’t stop.

Class, I'd like us all to give a warm mayflower elementary welcome to your new friend and classmate Jing Jang!" "Jin Wang" "Jin wang!" "He and his family recently moved to our neighborhood all the way from China!" "San Francisco." "San Francisco!" "Yes, Timmy." "My momma says Chinese people eat dogs." "Now be nice, Timmy!" -km sure Jin doesn't do that! In fact, Jin's family probably stopped that sort of thing as soon as they came to the united states!" The only other asian in my class was Suzy Nakamura. When the class finally figured out that we weren't related, rumors began to circulate that suzy and I were arranged to be married on her thirteenth birthday. We avoided each other as much as possible. (30-31)

There was not a single smoker in Europe before the sixteenth century, because until then there was no tobacco there. Very few women smoked until the twentieth century; now the habit is more popular among young women than among young men. To say that individual differences in smoking are half caused by genes is simply not true. It all depends on the environment in which the individual is living.

He swirled his drink and stared off into the crowd, terribly satisfied. “Have you ever seen a face so weirdly symmetrical? Put our man Luca Catenacci on a poster for…Sicilian cologne. Those genes? With the whole Vitelli-Marzano thing you’ve got going?” He issued a low whistle. “Unstoppable.

I could have made analytical comparisons with kisses I’d had from other boys, trying to work out just why Gideon did it so much better. I might also have stopped to remember that there was a wall between us, and a confessional window through which Gideon had squeezed his head and arms, and these were not the ideal conditions for kissing. Quite apart from the fact that I could do without any more chaos in my life, after discovering only two days ago that I’d inherited my family’s time-traveling gene. The fact was, however, that I hadn’t been thinking anything at all, except maybe oh and hmm and more! That’s why I hadn’t noticed the flip-flop sensation inside me, and only new, when the little gargoyle folded his arms and flashed his eyes at me from his pew, only when I saw the confessional curtain—brown, although it had been green velvet a moment ago—did I work it out that meanwhile we’d traveled back to the present. “Hell!” Gideon moved back to his side of the confessional and rubbed the back of his head. Hell? I came down from cloud nine with a bump and forgot the gargoyle. “Oh, I didn’t think it was that bad,” I said, trying to sound as casual as possible. Unfortunately, I was rather breathless, which tended to spoil the effect. I couldn’t look Gideon in the eye, so instead I kept staring at the brown polyester curtain in the confessional.

I could be wrong, but red hair is common in one particular family in this area of the Psy. The NightStar line has an unusually high incidence of the recessive gene." Sascha sounded utterly Psy at that moment. That was to be expected. She hadn't been cat for much more than a few months. It would take time.

In 1969, both John and I began job hunting. I had finished my second master’s degree and started sending out resumes. I got several offers from various schools—Metropolitan State University in Denver, Keene State College in New Hampshire—and John also had some offers. But neither of us wanted to be a “trailing spouse.” What to do?Then we went to the College Art Association conference in Washington, D.C., and met Gene Grissom, chair of the art department at the University of Florida. They were looking for a young faculty member with some administrative experience, and John fit the bill perfectly. There was also a possibility for me to teach either art history or humanities. After several weeks of negotiations, we decided to make the move to Florida where BOTH of us had jobs!

For women: In your autumn years, having a successful career behind you will be nothing compared to having a large family, with grandchildren and everything else that comes with it. This is also the best and most natural method for ensuring your retirement benefits — a few decades from now, your children and grandchildren will be far more inclined to take care of you than the rapidly crumbling European welfare states will. Besides, passing your genes on is a far worthier goal in life than slaving for some multinational corporation, which will forget all about you the second you retire. Furthermore, the plummeting birth rates of Europe must be reversed. Make sure to have at least three children, and raise them well. In this regard, the future of Europe rests squarely in your hands.

Sturtevant’s rudimentary genetic map would foreshadow the vast and elaborate efforts to map genes along the human genome in the 1990s. By using linkage to establish the relative positions of genes on chromosomes, Sturtevant would also lay the groundwork for the future cloning of genes tied to complex familial diseases, such as breast cancer, schizophrenia, and Alzheimer’s disease. In about twelve hours, in an undergraduate dorm room in New York, he had poured the foundation for the Human Genome Project.

Mandalorians are surprisingly unconcerned with biological lineage. Their definition of offspring or parent is more by relationship than birth: adoption is extremely common, and it’s not unusual for soldiers to take war orphans as their sons or daughters if they impress them with their aggression and tenacity. They also seem tolerant of marital infidelity during long separations, as long as any child resulting from it is raised by them. Mandalorians define themselves by culture and behavior alone. It is an affinity with key expressions of this culture—loyalty, strong self-identity, emphasis on physical endurance and discipline—that causes some ethnic groups such as those of Concord Dawn in particular to gravitate toward Mandalorian communities, thereby reinforcing a common set of genes derived from a wide range of populations. The instinct to be a protective parent is especially dominant. They have accidentally bred a family-oriented warrior population, and continue to reinforce it by absorbing like-minded individuals and groups.

But what was family? Surely more than genes, eye color, flesh. Family was story: truth and struggle and retribution. Family was time.

The accrued guilt and clutter of day-to-day existence—the lapses of conscience, the unpaid bills, the bungled opportunities, the dust under the couch, the festering familial sores, the inescapable prison of your genes—all of it is temporarily forgotten, crowded from your thoughts by an overpowering clarity of purpose, and by the seriousness of the task at hand.

In genealogy you might say that interest lies in the eye of the gene holder. The actual descendants are far more intrigued with it all than the listeners, who quickly sink into a narcoleptic coma after the second or third great-great-somebody kills a bear or beheads Charles I, invents the safety pin or strip-mines Poland, catalogues slime molds, dances flamenco, or falls in love with a sheep. Genealogy is a forced march through stories. Yet everyone loves stories, and that is one reason we seek knowledge of our own blood kin. Through our ancestors we can witness their times. Or, we think, there might be something in their lives, an artist’s or a farmer’s skill, an affection for a certain landscape, that will match or explain something in our own. If we know who they were, perhaps we will know who we are. And few cultures have been as identity-obsessed as ours. So keen is this fascination with ancestry, genealogy has become an industry. Family reunions choke the social calendar. Europe crawls with ancestor-seeking Americans. Your mother or your spouse or your neighbors are too busy to talk to you because they are on the Internet running “heritage quests.” We have climbed so far back into our family trees, we stand inches away from the roots where the primates dominate.

the Christian life is to be lived in vocation, in the seemingly ordinary walks of life that take up nearly all of the hours of our day. The Christian life is to be lived out in our family, our work, our community, and our church. Such things seem mundane, but this is because of our blindness. Actually, God is present in them—and in us—in a mighty, though hidden, way.

The meaning of sex is illustrated by two eponymous heroes of British history, King Edward VII (who flourished in the years before the First World War) and the King Edward variety of potato which has fed the British working class for almost as long). The potato, unlike the royal family, reproduces asexually. Every King Edward potato is identical to every other and each on has the same set of genes as the hoary ancestor of all potatoes bearing that name. This is convenient for the farmer and the grocer, which is why sex is not encouraged among potatoes.

How dare I complain. I was born in the right time and right place to the right family. I met a man and we built a life together. Yet sometimes even the most charmed existence can change in the blink of an eye, or turn on the length of an eyelash. One moment of indecision. A cancer cell. A rogue gene. A wrong turn. A red light. A drunk driver. A cruel piece of misfortune.

Luther goes so far as to say that vocation is a mask of God. That is, God hides Himself in the workplace, the family, the Church, and the seemingly secular society. To speak of God being hidden is a way of describing His presence, as when a child hiding in the room is there, just not seen. To realize that the mundane activities that take up most of our lives—going to work, taking the kids to soccer practice, picking up a few things at the store, going to church—are hiding-places for God can be a revelation in itself. Most people seek God in mystical experiences, spectacular miracles, and extraordinary acts they have to do. To find Him in vocation brings Him, literally, down to earth, makes us see how close He really is to us, and transfigures everyday life.

hemophilia is an inherited blood-clotting deficiency, transmitted by women according to the sex-linked recessive Mendelian pattern. Thus, while women carry the defective genes, they almost never suffer from the disease. With rare exceptions, it strikes only males. Yet it does not necessarily strike all the males in a family. Genetically as well as clinically, hemophilia is capricious.

A quote about Carla Kelly - We used to have a family saying around the dinner table. For expediency in feeding our large number of children we would sometimes forego the use of a serving dish and just put one pot or another on the table. The expression was, "It's okay - Carla Kelly isn't here today." Dinner at the Kellys, and Carla's insistence on proper dining decorum was always a bright spot in our occasional family visits. - Gene McAvoy 7-22-10

Not a single family finds itself exempt from that one haunted casualty who suffered irreparable damage in the crucible they entered at birth. Where some children can emerge from conditions of soul-killing abuse and manage to make their lives into something of worth and value, others can’t limp away from the hurts and gleanings time decanted for them in flawed beakers of memory. They carry the family cross up the hill toward Calvary and don’t mind letting every other member of their aggrieved tribe in on the source of their suffering. There is one crazy that belongs to each of us: the brother who kills the spirit of any room he enters; the sister who’s a drug addict in her teens and marries a series of psychopaths, always making sure she bears their children, who carry their genes of madness to the grave. There’s the neurotic mother who’s so demanding that the sound of her voice over the phone can cause instant nausea in her daughters. The variations are endless and fascinating. I’ve never attended a family reunion where I was not warned of a Venus flytrap holding court among the older women, or a pitcher plant glistening with drops of sweet poison trying to sell his version of the family maelstrom to his young male cousins. When the stories begin rolling out, as they always do, one learns of feuds that seem unbrokerable, or sexual abuse that darkens each tale with its intimation of ruin. That uncle hates that aunt and that cousin hates your mother and your sister won’t talk to your brother because of something he said to a date she later married and then divorced. In every room I enter I can sniff out unhappiness and rancor like a snake smelling the nest of a wren with its tongue. Without even realizing it, I pick up associations of distemper and aggravation. As far as I can tell, every family produces its solitary misfit, its psychotic mirror image of all the ghosts summoned out of the small or large hells of childhood, the spiller of the apple cart, the jack of spades, the black-hearted knight, the shit stirrer, the sibling with the uncontrollable tongue, the father brutal by habit, the uncle who tried to feel up his nieces, the aunt too neurotic ever to leave home. Talk to me all you want about happy families, but let me loose at a wedding or a funeral and I’ll bring you back the family crazy. They’re that easy to find.

Human vice is proof that biological adaption is, speaking literally, a thing of the past. Our minds are adapted to the small foraging bands in which our family spent ninety-nine percent of its existence, not the topsy-turvy contingencies we have created since the agricultural and industrial revolutions. [...] People do not divine what is adaptive for them or their genes; their genes give them thoughts and feelings that were adaptive in the environment in which the genes were selected.

It must come from your father's side of the family," Allison informed her with severe disapproval. "You never got that sort of dreary, plebeian logic from my genes, dear! Beowulfans' cognitive processes rely far more on the creative and intuitive manipulation of concepts without the drudgery of applying reason to them. Don't you realize how badly you can damage a perfectly good preconception or assumption if you insist on thinking about it that way? That's why I never indulge in such a vice.

It is one thing when the culture doesn’t “get” adoption. What else could one expect when all of life is seen as the quest of “selfish genes” for survival? It is one thing when the culture doesn’t “get” adoption and so speaks of buying a cat as “adopting” a pet.

I should tell her to leave. I should maintain what dignity I can, which isn’t much considering I’m wearing a blanket and the smell of last night’s drinking. But my family is pretty shit at dignity as well as love, so I think: fuck dignity. Dignity is not in my genes

Suppose a person harmed people two generations ago; are this person’s grandchildren obliged to help his victims’ grandchildren? Subjects viewed a biological grandchild as more obligated than one adopted into the family at birth; the biological relationship carried a taint. Moreover, subjects were more willing to jail two long-lost identical twins for a crime committed by one of them than to jail two unrelated but perfect look-alikes—the former, raised in different environments, share a moral taint because of their identical genes.

The conclusion that all these studies converge upon is that about half of your IQ was inherited, and less than a fifth was due to the environment you shared with your siblings – the family. The rest came from the womb, the school and outside influences such as peer groups. But even this is misleading. Not only does your IQ change with age, but so does its heritability. As you grow up and accumulate experiences, the influence of your genes increases. What? Surely, it falls off? No: the heritability of childhood IQ is about forty-five per cent, whereas in late adolescence it rises to seventy-five per cent. As you grow up, you gradually express your own innate intelligence and leave behind the influences stamped on you by others. You select the environments that suit your innate tendencies, rather than adjusting your innate tendencies to the environments you find yourself in. This proves two vital things: that genetic influences are not frozen at conception and that environmental influences are not inexorably cumulative. Heritability does not mean immutability.

I like nature and I enjoy walking through the forest admiring its beauty and breathing not just the fresh air but, also the quietness and peacefulness of the place. There I feel serene. I feel I am accepted just the way I am whenever I arrive and for as long as I stay. Yes, there it doesn’t matter how I look, what country I come from, if I am from rich or poor family, what is my education, income, religion, sexual orientation and color of skin. It doesn’t even care if my hair looks messy and whether I wear the latest fashion cloths.

Exploring Self-Compassion Through Letter Writing PART ONE Everybody has something about themselves that they don’t like; something that causes them to feel shame, to feel insecure or not “good enough.” It is the human condition to be imperfect, and feelings of failure and inadequacy are part of the experience of living. Try thinking about an issue that tends to make you feel inadequate or bad about yourself (physical appearance, work or relationship issues, etc.). How does this aspect of yourself make you feel inside—scared, sad, depressed, insecure, angry? What emotions come up for you when you think about this aspect of yourself? Please try to be as emotionally honest as possible and to avoid repressing any feelings, while at the same time not being melodramatic. Try to just feel your emotions exactly as they are—no more, no less. PART TWO Now think about an imaginary friend who is unconditionally loving, accepting, kind, and compassionate. Imagine that this friend can see all your strengths and all your weaknesses, including the aspect of yourself you have just been thinking about. Reflect upon what this friend feels toward you, and how you are loved and accepted exactly as you are, with all your very human imperfections. This friend recognizes the limits of human nature and is kind and forgiving toward you. In his/her great wisdom this friend understands your life history and the millions of things that have happened in your life to create you as you are in this moment. Your particular inadequacy is connected to so many things you didn’t necessarily choose: your genes, your family history, life circumstances—things that were outside of your control. Write a letter to yourself from the perspective of this imaginary friend—focusing on the perceived inadequacy you tend to judge yourself for. What would this friend say to you about your “flaw” from the perspective of unlimited compassion? How would this friend convey the deep compassion he/she feels for you, especially for the discomfort you feel when you judge yourself so harshly? What would this friend write in order to remind you that you are only human, that all people have both strengths and weaknesses? And if you think this friend would suggest possible changes you should make, how would these suggestions embody feelings of unconditional understanding and compassion? As you write to yourself from the perspective of this imaginary friend, try to infuse your letter with a strong sense of the person’s acceptance, kindness, caring, and desire for your health and happiness. After writing the letter, put it down for a little while. Then come back and read it again, really letting the words sink in. Feel the compassion as it pours into you, soothing and comforting you like a cool breeze on a hot day. Love, connection, and acceptance are your birthright. To claim them you need only look within yourself.

What the fuck is this rubbish supposed to be? Special treatment? Ha, it isn’t fucking Halloween, you oddball pack of Addams family rejects. I told you Mini-Morticia was a fucking freak and here’s the proof. Looks like the whole family spend a little too much time swimming around in the murky end of the gene pool.

Stuff happens to most people. One thing going wrong, I mean. One family member missing a chance to help. One who cuts you off. One person with her own shit to deal with. One of those things isn't enough to send you falling through the cracks. But all of them together, they accumulate. An abandoned mother here. A missing uncle there. A disappearing father 2 generations back. A friendship broken by fear or mistrust or addiction. Genes that make you vulnerable to certain problems. Two children who aren't loved right meeting up when they're not really adults yet and having 2 more children who aren't loved right. It adds up. It all adds up.

We must pass along the good word that the one thing America needs above every other thing on earth is HOMES AND HEARTS BIG ENOUGH FOR CHILDREN, as were the homes of our grandfathers, when no joy in life equaled the joy of a new child in the family, and if you didn't have a dozen you weren't doing your manifest duty." "Well,

A genetic fundamentalism permeates public awareness these days. It may be summed up as the belief that almost every illness and every human trait is dictated by heredity. Simplified media accounts, culled from semidigested research findings, have declared that inflexible laws of DNA rule the biological world. It was reported in 1996 that according to some psychologists, genes determine about 50 percent of a person’s inclination to experience happiness. Social ability and obesity are two more among the many human qualities now claimed to be genetic. True or not, narrow genetic explanations for ADD and every other condition of the mind do have their attractions. They are easy to grasp, socially conservative and psychologically soothing. They raise no uncomfortable questions about how a society and culture might erode the health of its members, or about how life in a family may have affected a person’s physiology or emotional makeup. As I have personally experienced, feelings of guilt are almost inevitable for the parents of a troubled child. They are all too frequently reinforced by the uninformed judgments of friends, neighbors, teachers or even total strangers on the bus or in the supermarket. Parental guilt, even if misplaced, is a wound for which the genetic hypothesis offers a balm

My fight isn’t so simple, it has very deep roots, from long ago, from earlier generations. Life weighs on me with the weight of my family history, my genes drag along a race of sons of plenty and sons of bitches who with a blade of a machete cleared the pathways of life. They’re still doing it. They ate with the machete, they worked, they shaved, killed, and settled differences with their wives with machete. Today the machete is a shotgun, a nine-millimeter, a chopper. The weapon has changed but not its use. The story has changed, too, has become terrifying. Once proud, we are now ashamed, without understanding how, why, and when it all happened. We don’t know how long our history is, but we can feel its weight.

Grandma was a sheltered southern belle from Kentucky. The sort of high-yellow woman who believed her fair complexion was the result of an errant Native American gene, but who was, like so many of us, walking proof of American industry, the bolls and ships and casual sexual terrorism that put a little cream in the coffee and made her family loyal to the almighty paper bag.

The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. When I started my research, sirtuins were barely on the scientific radar. Now this family of genes is at the forefront of medical research and drug development. Descended from gene B in M. superstes, sirtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.

Biology is destiny, to a point. We are more than just our genes. We are in some way a product of the people that surround us, the people we are forced to grow up with and the people we choose to be with later. Our relationships can destroy us, but they can change us too, and restore us, and without us ever seeing it happen, they define us. We are human because the people around us make us human.

So far, so good, but what about the man who rushes headlong into the fire to save a complete stranger? The stranger is probably not genetically related to the man who helps him, so this act must surely be truly unselfish and altruistic? The answer is Yes, but only by accident. The accident is caused by the rapid growth of human populations in the last few thousand years. Previously, for millions of years, man was tribal and any inborn urge to help his fellow-men would have meant automatically that he was helping gene-sharing relatives, even if only remote ones. There was no need for this urge to be selective, because there were no strangers around to create problems. But with the urban explosion, man rapidly found himself in huge communities, surrounded by strangers, and with no time for his genetic constitution to alter to fit the startlingly new circumstances. So his altruism inevitably spread to include all his new fellow-citizens, even though many of them may have been genetically quite unrelated to him. Politicians, exploiting this ancient urge, were easily able to spread the aid-system even further, to a national level called patriotism, so that men would go and die for their country as if it were their ancient tribe or their family.

You’ve got that extra gene, that sensitivity toward women. That unwillingness to objectify the opposite sex, isn’t that what they say about you? That you invent a female character and put her in a marriage, a family, a king-sized bed in the suburbs, and yet you don’t feel the need to describe . . . I don’t know, her pubic hair in literary terms: ‘a burnt-sienna nimbus,’ or whatever, like the rest of your crowd would.

The Swedish town of Överkalix has the most comprehensive and oldest birth, death, and crop records in the world. Their records go back generations—a remarkably rich data set. And in analyzing this data set, scientists found some fascinating correlations. There were good and bad years for the crops in Överkalix and some particularly bad years where families were forced to go hungry. But scientists discovered that when children suffered starvation between the ages of nine and twelve, their grandchildren would on average live thirty years longer. Their descendants had far lower rates of diabetes and heart disease. On the other hand, when children were well-fed during those ages, their descendants were at four times the risk for heart attacks and their life expectancy dropped. In some strange way, the trauma of starvation changed descendants’ genes to be more resilient. Healthier. More likely to survive.[5] — Clearly, it wasn’t just my ruthless nurture that had shaped me into who I was, though who knows what kind of rampant methylation savaged my epigenome during my beatings and assaults. Beyond that, every cell in my body is filled with the code of generations of trauma, of death, of birth, of migration, of history that I cannot understand. Just piecemeal moments I collected from Auntie over the years. My family tried to erase this history. But my body remembers. My work ethic. My fear of cockroaches. My hatred for the taste of dirt. These are not random attributes, a spin of the wheel. They were gifted to me with purpose, with necessity. I want to have words for what my bones know. I want to use those gifts when they serve me and understand and forgive them when they do not.

When I interviewed with the Chief of Family Medicine at a large medical corporation on the West Coast, he explained that, since he was part of a team of people who arranged for pharmaceutical companies to issue cash grants, he was in a position to offer me a particularly enticing salary. “What are the grants for?” I asked. “We have a quality improvement program that tracks physician prescribing patterns. We call it ‘quality’ but it’s really about money.” And that’s all it’s about. It works like this. In his organization, any patient with LDL cholesterol over 100 is put on a cholesterol-lowering medication. Any person with a blood pressure higher than 140/90 is put on a blood pressure medication. Any person with “low bone density” is put on a bone-remodeling inhibitor. And so on. The doctors who prescribe the most get big bonuses. Those who prescribe the least get fired. With a hint of incredulousness in his voice, he explained, “So far, every time we’ve asked for funding for our program, the drug companies give it to us.” If this is where healthcare is headed, then these hybrid physicians-executives will instinctively turn their gaze to our children and invent more creative methods to bulldoze an entire generation into the bottomless pit of chronic disease.

Oh, do you, Milo? You’re so selfish. You don’t see the bigger picture.” “What’s the bigger picture?” “You’re still here looking for handouts. Who’s going to take care of me?” “I’m on my knees here, Mom. Not for me, for my family. For my wife. For a beautiful grandson you have totally ignored.” “He’s kind of a brat. I’ll be in his life when he gets a little impulse control.” “He’s not even four.” “I have needs. I’m tired of this child-worshipping culture. You’re just a slave to it, Milo.” “I’m only trying to be a decent dad.” “Don’t waste your time. It’s not in your genes. Besides, try making some money. That might be a good dad move. For heaven’s sake, the system’s rigged for white men and you still can’t tap in.” “You’re right, Mom. What can I say? But still, it would mean a lot to me if you made a little more of an effort with Bernie.” “Bernie schmernie. This is my decade.” “Okay, you wrinkled old spidercunt, have it your way.

Scientists now believe it’s even possible that our genetic expression fluctuates on a moment-to-moment basis. The research is revealing that our thoughts and feelings, as well as our activities—that is, our choices, behaviors, and experiences—have profound healing and regenerative effects on our bodies, as the men in the monastery study discovered. Thus your genes are being affected by your interactions with your family, friends, co-workers, and spiritual practices, as well as your sexual habits, your exercise levels, and the types of detergents you use. The latest research shows that approximately 90 percent of genes are engaged in cooperation with signals from the environment.8 And if our experience is what activates a good number of our genes, then our nature is influenced by nurturing. So why not harness the power of these ideas so that we can do everything possible to maximize our health and minimize our dependence on the prescription pad?

Twin, family, and population studies have all conclusively shown that psychological traits are at least partly, and sometimes largely, heritable—that is, a sizable portion of the variation that we see in these traits across the population is attributable to genetic variation. However, as we have seen in the preceding chapters, the relationship between genes and traits is far from simple. The fact that a given trait is heritable seems to suggest that there must be genes for that trait. But phrasing it in that way is a serious conceptual trap. It implies that genes exist that are dedicated to that function—that there are genes for intelligence or sociability or visual perception. But this risks confusing the two meanings of the word gene: one, from the study of heredity, refers to genetic variants that affect a trait; the other, from molecular biology, refers to the stretches of DNA that encode proteins with various biochemical or cellular functions.

If the Nephilim were the offspring of demons and women, what if Satan’s intent was to pervert the human gene pool so that the Savior promised in the garden of Eden could never come?” It would have made the Flood merciful beyond dispute because God sending the Flood would have purified the gene pool and allowed for the redemption of humankind through Jesus. Mercy through judgment. A theme we see all throughout the Bible, just as we see how mercy can become a sort of punishment.

But there’s this way he drums his fingers on the table. Not even like really drumming. More like in-way between drumming and like this scratching, picking, the way you see somebody picking at dead skin. And without any kind of rhythm, see, constant and never-stopping but with no kind of rhythm you could grab onto and follow and stand. Totally like whacked, insane. Like the kind of sounds you can imagine a girl hears in her head right before she kills her whole family because somebody took the last bit of peanut butter or something. You know what I’m saying? The sound of a fucking mind coming apart. You know what I’m saying? So yeah, yes, OK, the short answer is when he wouldn’t quit with the drumming at supper I sort of poked him with my fork. Sort of. I could see how maybe somebody could have thought I sort of stabbed him. I offered to get the fork out, though. Let me just say I’m ready to make amends at like anytime. For my part in it. I’m owning my part in it is what I’m saying. Can I ask am I going to get Restricted for this? Cause I have this Overnight tomorrow that Gene he approved already in the Overnight Log. If you want to look. But I’m not trying to get out of owning my part of the, like, occurrence. If my Higher Power who I choose to call God works through you saying I’ve got some kind of a punishment due, I won’t try to get out of a punishment. If I’ve got one due. I just wanted to ask. Did I mention I’m grateful to be here?

Normal cells could acquire these cancer-causing mutations through four mechanisms. The mutations could be caused by environmental insults, such as tobacco smoke, ultraviolet light, or X-rays—agents that attack DNA and change its chemical structure. Mutations could arise from spontaneous errors during cell division (every time DNA is replicated in a cell, there’s a minor chance that the copying process generates an error—an A switched to a T, G, or C, say). Mutant cancer genes could be inherited from parents, thereby causing hereditary cancer syndromes such as retinoblastoma and breast cancer that coursed through families. Or the genes could be carried into the cells via viruses, the professional gene carriers and gene swappers of the microbial world. In all four cases, the result converged on the same pathological process: the inappropriate activation or inactivation of genetic pathways that controlled growth, causing the malignant, dysregulated cellular division that was characteristic of cancer.

family? Surely more than genes, eye color, flesh. Family was story: truth and struggle and retribution. Family was time. At the other end of the continent Felix was lying in a hospital bed, asleep, surrounded by kin—Soma and the boys, the ghosts of the Chileans he had known, the disappeared, the still-here. Winkler had a single memory of an infant girl at a window. Faces in a dream, phantoms in the periphery. If he had learned anything it was that family was not so much what you were given as what you were able

Does God "temper the wind to the shorn lamb"? Does He never ask more of us than we can endure? My experience, alas, has been otherwise. I have seen people crack under the strain of unbearable tragedy. I have seen marriages break up after the death of a child, because parents blamed each other for not taking proper care or for carrying the defective gene, or simply because the memories they shared were unendurably painful. I have seen some people made noble and sensitive through suffering, but i have seen many more people grow cynical and bitter. I have seen people become jealous of those around them, unable to take part in the routines of normal living. I have seen cancers and automobile accidents take the life of one member of a family, and functionally end the lives of five others, who could never again be the normal, cheerful people they were before disaster struck. If God is testing us, He must know by now that many of us fail the test. If He is only giving us the burdens we can bear, I have seen Him miscalculate far too often.

GLF deplored the embedded class structure that most Americans denied existed (even as it kept them locked in the cellar) and rejected, too, the claim that traditional notions of “maleness” and “femaleness” were biologically grounded—that our genes and hormones dictated and warranted the view that women were intrinsically emotional and men intrinsically aggressive. Further, and centrally, the early gay movement affirmed sexual pleasure as a positive good, vigorously condemned the nuclear family as nothing more than a detention center for women and children, and viewed monogamy as unnatural.

Should we consider allowing parents to fully sequence their children’s genomes and potentially terminate pregnancies with such known devastating genetic mutations? We would certainly eliminate Erika’s mutation from the human gene pool—but we would eliminate Erika as well. I will not minimize the enormity of Erika’s suffering, or that of her family—but there is, indubitably, a deep loss in that. To fail to acknowledge the depth of Erika’s anguish is to reveal a flaw in our empathy. But to refuse to acknowledge the price to be paid in this trade-off is to reveal, conversely, a flaw in our humanity.

Just as summer-killed meat draws flies, so the court draws spurious sages, philosophists, and acosmists who remain there as long as their purses and their wits will maintain them, in the hope (at first) of an appointment from the Autarch and (later) of obtaining a tutorial position in some exalted family. At sixteen or so, Thecla was attracted, as I think young women often are, to their lectures on theogony, thodicy, and the like, and I recall one particularly in which a phoebad put forward as an ultimate truth the ancient sophistry of the existence of three Adonai, that of the city (or of the people), that of the poets, and that of the philosophers. Her reasoning was that since the beginning of human consciousness (if such a beginning ever was) there have been vast numbers of persons in the three categories who have endeavored to pierce the secret of the divine. If it does not exist, they should have discovered that long before; if it does, it is not possible that Truth itself should mislead them. Yet the beliefs of the populace, the insights of the rhapsodists, and the theories of the metaphysicians have so far diverged that few of them can so much as comprehend what the others say, and someone who knew nothing of any of their ideas might well believe there was no connection at all between them. May it not be, she asked (and even now I am not certain I can answer), that instead of traveling, as has always been supposed, down three roads to the same destination, they are actually traveling toward three quite different ones? After all, when in common life we behold three roads issuing from the same crossing, we do not assume they all proceed toward the same goal. I found (and find) this suggestion as rational as it is repellent, and it represents for me all that monomaniacal fabric of argument, so tightly woven that not even the tiniest objection or spark of light can escape its net, in which human minds become enmeshed whenever the subject is one in which no appeal to fact is possible. As a fact the Claw was thus an incommensurable. No quantity of money, no piling up of archipelagoes or empires could approach it in value any more than the indefinite multiplication of horizontal distance could be made to equal vertical distance. If it was, as I believed, a thing from outside the universe, then its light, which I had seen shine faintly so often, and a few times brightly, was in some sense the only light we had. If it were destroyed, we were left fumbling in the dark.

In middle age you no longer thought such thoughts about free choice. Then it came over you that from one grandfather you had inherited such and such a head of hair which looked like honey when it whitens or sugars in the jar; from another, broad thick shoulders; an oddity of speech from one uncle, and small teeth from another, and the gray eyes with darkness diffused even into the whites, and a wide-lipped mouth like a statue from Peru. Wandering races have such looks, the bones of one tribe, the skin of another. From his mother he had gotten sensitive feelings, a soft heart, a brooding nature, a tendency to be confused under pressure.

To understand the rise of Christianity or the French Revolution, it is not enough to comprehend the interaction of genes, hormones and organisms. It is necessary to take into account the interaction of ideas, images and fantasies as well. This does not mean that Homo sapiens and human culture became exempt from biological laws. We are still animals, and our physical, emotional and cognitive abilities are still shaped by our DNA. Our societies are built from the same building blocks as Neanderthal or chimpanzee societies, and the more we examine these building blocks – sensations, emotions, family ties – the less difference we find between us and other apes. It

As a nation, our people are pampering themselves and living for their own pleasures. They won't take the trouble or endure the pain required to bear and to rear children; and the day is rolling toward us, with every turn of the planet one day closer, when we are going to be outnumbered by a combination of peoples who can take our own tricks and beat us with them. We must pass along the good word that the one thing America needs above every other thing on earth is HOMES AND HEARTS BIG ENOUGH FOR CHILDREN, as were the homes of our grandfathers, when no joy in life equaled the joy of a new child in the family, and if you didn't have a dozen you weren't doing your manifest duty.

Scientists now believe it’s even possible that our genetic expression fluctuates on a moment-to-moment basis. The research is revealing that our thoughts and feelings, as well as our activities—that is, our choices, behaviors, and experiences—have profound healing and regenerative effects on our bodies, as the men in the monastery study discovered. Thus your genes are being affected by your interactions with your family, friends, co-workers, and spiritual practices, as well as your sexual habits, your exercise levels, and the types of detergents you use. The latest research shows that approximately 90 percent of genes are engaged in cooperation with signals from the environment.

In America, straightforward talk about class inequality is all but impossible, indeed taboo. Political appeals to the economic self-interest of ordinary voters, as distinct from their wealthy compatriots, court instant branding and disfigurement in the press as divisive “economic populism” or even “class warfare.”39 On the other hand, divisive political appeals composed in a different register, sometimes called “cultural populism,” enlist voters’ self-concept in place of their self-interest; appealing, in other words, to who they are and are not, rather than to what they require and why. Thus, the policies of the 1980s radically redistributed income upward. Then, with “economic populism” shooed from the public arena, “cultural populism” fielded something akin to a marching band. It had a simple melody about the need to enrich the “investing” classes (said to “create jobs”), and an encoded percussion: “culture wars”; “welfare mothers”; “underclass”; “race-and-IQ”; “black-on-black crime”; “criminal gene”; on and on.40 Halfway through the decade, as the band played on, a huge economic revolution from above had got well under way. The poorest 40 percent of American families were sharing 15.5 percent of household income, while the share of the richest 20 percent of families had risen to a record 43.7 percent, and the trend appeared to be (and has turned out to be) more and more of the same.41 The

Scientists know your DNA reflects the genetic legacy of your parents, their parents, and your ancestors. It’s possible that it also reflects their emotional experiences. As researchers learn more about our DNA, maybe we’ll find that our cells have encoded the traumas of our ancestors. Experiments in mice have shown that aversion to certain smells is passed down to the offspring after the parental mice were trained to avoid a certain smell by being shocked every time they smelled it.8 While we know that a family history of heart disease may mean close relatives share genes and genetic markers, if we look back, we can often see in family stories hearts that are broken, conflicted, and prevented from loving fully. In my family, people tend to die of heart disease prematurely. My maternal

What no one then, of course, knew was that as female children of the tsaritsa, one or all of the sisters might be carriers of that terrible defective gene – a hidden time bomb that had already begun to reverberate across the royal families of Europe. Alexandra’s elder sister Irene – who like her was a carrier and who had married her first cousin, Prince Henry of Prussia – had already given birth to two haemophiliac sons. The youngest, four-year-old Heinrich, had died – ‘of the terrible illness of the English family’, as Xenia described it – just five months before Alexey was born. In Russia they called it the bolezn gessenskikh – ‘the Hesse disease’; others called it ‘the Curse of the Coburgs’.66 But one thing was certain; in the early 1900s, the life expectancy of a haemophiliac child was only about thirteen years.67

Pretty soon, however, I noticed something familiar. Most books are also about the exceptional. The biggest history bestsellers are invariably about catastrophes and adversity, tyranny and oppression. About war, war, and, to spice things up a little, war. And if, for once, there is no war, then we’re in what historians call the interbellum: between wars. In science, too, the view that humanity is bad has reigned for decades. Look up books on human nature and you’ll find titles like Demonic Males, The Selfish Gene and The Murderer Next Door. Biologists long assumed the gloomiest theory of evolution, where even if an animal appeared to do something kind, it was framed as selfish. Familial affection? Nepotism! Monkey splits a banana? Exploited by a freeloader!31 As one American biologist mocked, ‘What passes for co-operation turns out to be a mixture of opportunism and exploitation. […] Scratch an “altruist” and watch a “hypocrite” bleed.’32 And in economics? Much the same. Economists defined our species as the homo economicus: always intent on personal gain, like selfish, calculating robots. Upon this notion of human nature, economists built a cathedral of theories and models that wound up informing reams of legislation. Yet no one had researched whether homo economicus actually existed. That is, not until economist Joseph Henrich and his team took it up in 2000. Visiting fifteen communities in twelve countries on five continents, they tested farmers, nomads, and hunters and gatherers, all in search of this hominid that has guided economic theory for decades. To no avail. Each and every time, the results showed people were simply too decent. Too kind.

Nobody is suggesting that children deliberately and consciously deceive their parents because of the selfish genes within them. And I must repeat that when I say something like 'A child should lose no opportunity of cheating . . . lying, deceiving, exploiting.. .', I am using the word 'should' in a special way. I am not advocating this kind of behaviour as moral or desirable. I am simply saying that natural selection will tend to favour children who do act in this way, and that therefore when we look at wild populations we may expect to see cheating and selfishness within families. The phrase 'the child should cheat' means that genes that tend to make children cheat have an advantage in the gene pool. If there is a human moral to be drawn, it is that we must teach our children altruism, for we cannot expect it to be part of their biological nature.

Cordelia – “Why so rough?” Aral – “It’s very poor. It was the town center during the time Isolation. And it hasn’t been touched by renovation, minimal water, no electricity choked with refuse.” “Mostly human,” added Peoter tartly. “Poor?” Asked Cordelia bewildered. “No electricity? How can it be on the comm network?” “It’s not of course,” answered Vorkosigan. “Then how can anyone get their schooling?” Cordelia “They don’t.” Cordelia stared. “I don’t understand, how do they get their jobs?” “A few escape to the service, the rest prey on each other mostly.” Vorkosigan regarded her face uneasily. “Have you no poverty on Beta colony?” “Poverty? Well some people have more money than others, but no comm consuls…?” Vorkosigan was diverted from his interrogation. “Is not owning a comm consul the lowest standard of living you can imagine?” He said in wonder. “It’s the first article in the constitution! ‘Access to information shall not be abridged.’” “Cordelia, these people barely have access to food, clothing and shelter. They have a few rags and cooking pots and squat in buildings that aren’t economical to repair or tear down yet with the wind whistling through the walls.” “No air conditioning?” “No heat in the winter is a bigger problem here.” “I suppose so. You people don’t really have summer. How do they call for help when they are sick or hurt?” “What help?” Vorkosigan was growing grim. “If they’re sick they either get well or die.” “Die if we’re lucking” muttered Veoter. “You’re not joking.” She stared back and forth between the pair of them. “Why, think of all the geniuses you must missing!” “I doubt we must be missing very many from the Caravanceri.” Said Peoter dryly. “Why not? They have the same genetic compliment as you.” Cordelia pointed out the – to her -obvious. The Count went rigid. “My dear girl, they most certainly do not. My family has been Vor for nine generations.” Cordelia raised her eyebrows. “How do you know if you didn’t have the gene-typing until 80 years ago?” Both the guard commander and the footman were acquiring peculiar stuffed expressions. The footman bit his lip. “Besides,” she pointed out reasonably, “If you Vor got around half as much as those histories I’ve been reading imply. 90% of the people on this planet must have Vor blood by now. Who knows who your relatives are on your father’s side. Vorkosigan bit his napkin absently. His eyes gone crinkly with much the same expression as the footman and muttered, “Cordelia, you really can’t sit at the breakfast table and imply my ancestors were bastards. It’s a mortal insult here.” “Where should I sit? Oh I’ll never understand.

I do not believe in God. Instead I believe in the power of Family. And occasionally, when I’m feeling optimistic, in free will. But blood is a force to be reckoned with. God, for example, can’t give you an excellent head of hair. Your family can. They can also give you cancer. And heart disease. Nothing kills like Family. I see my past stretched out in front of me—one flawed, damaged, beleaguered ancestor after another. The secret. The tragedy. The unfulfilled promise. The one success that got away. My present is a conglomeration of the mistakes, missteps, dubious additions to the gene pool, and bad investments made by my parents, grandparents, great-grandparents, and great-great-grandparents. But after that, there is my future—what is left when the Family has left the building. Has finished fucking with me. It’s not much to work with, but it’s mine. Thank God for free will, right?

Devin was the most gorgeous, unique creature Kate had ever known. She'd come out of the womb an individual, refusing to be defined by anyone. She didn't even look like anyone on either side of their families. Matt's family was so proud of their dark hair, a blue-black that had been the envy of generations, the way it caught the sun like a spiderweb. From Kate's own side of the family, there was a gene that made their eyes so green that they could trick people into thinking that even the most unattractive Morris woman was pretty. And yet here was Devin, with fine cotton-yellow hair and light blue eyes, the left of which was a lazy eye. She'd had to wear an eye patch when she was three. And she'd loved it. She loved her knotted yellow hair. She loved wearing stripes with polka dots, and tutus, and pink and green socks with orange patent-leather shoes. Devin could care less what other people thought about her.

Before becoming Sam Goldwyn’s prized possession—and during a decade and more of taking roles that put him out there to be seen and perhaps noticed—Brennan did play characters who disparaged women. But what happened when he was offered the plum role of Jeeter Lester in John Ford’s production of Tobacco Road (March 7, 1941) is revealing. Erskine Caldwell’s best-selling novel had been a huge hit when it was adapted for the Broadway stage, and now the prestigious director was casting the film version with several actors—including Ward Bond, Gene Tierney, and Dana Andrews—whose careers would benefit from Ford’s attention. In Tobacco Road, Jeeter is the shiftless family patriarch. Not only does he lack ambition, his jokes, to Walter Brennan, seemed offensive. Ada, Jeeter’s wife, is demeaned just for laughs when he says she “never spoke a word to me for our first ten years we was married. Heh! Them was the happiest ten years of my life.

And you approve of your future sister-in-law?” Cade asked. “Sure. Isabelle seems great.” Her sister, on the other hand . . . Huxley studied him as he slid on his boxer briefs. “What’s the ‘but’?” “No ‘but,’” Vaughn said. “I like Simon’s fiancée.” And, fortunately for him, she inherited all the good-natured genes in the family. Cade furrowed his brow. “There it is again—that look. Like you want to say more.” Vaughn scoffed at that as he pulled on his clothes. “There’s no look.” Cade pointed. “Huxley just put on his underwear. Not once, in the two years that you two have been partners, have you ever missed an opportunity to smirk at the fact that the man irons his boxer briefs.” “Hey. They fold neater that way. It saves space in the drawer,” Huxley said. Cade gave Vaughn a look. I rest my case. “So? What gives?” Vaughn took in the tenacious expression on his friend’s face and knew that any further denials would only bring on more questions. He sighed. “Fine.” He thought about where to begin. “Isabelle has a sister.” Huxley rolled his eyes. “Here we go.” “No, no. Not here we go. She and I are not going anywhere,” Vaughn said emphatically. “The woman’s a . . .” He paused, trying to think of the right word. He caught sight of another agent, Sam Wilkins, passing by their row of lockers. The man was a walking dictionary. “Hey, Wilkins—what’s that word you used the other day, to describe the female witness who kept arguing with you?” “Termagant,” Wilkins called over. “Means ‘quarrelsome woman.’” Vaughn nodded at Cade and Huxley in satisfaction, thinking that definition perfectly captured Sidney Sinclair. “There. She’s a termagant.” “It can also mean ‘vixen,’” Wilkins shouted from the next aisle over. “Thank you, Merriam-Webster,” Vaughn called back, with a half growl. “I think we’ve got it.” Cade raised an eyebrow teasingly. “So. Does the vixen have a name?” Yep, Vaughn had walked right into that one. “Sidney

By the end of this decade, permutations and combinations of genetic variants will be used to predict variations in human phenotype, illness, and destiny. Some diseases might never be amenable to such a genetic test, but perhaps the severest variants of schizophrenia or heart disease, or the most penetrant forms of familial cancer, say, will be predictable by the combined effect of a handful of mutations. And once an understanding of "process" has been built into predictive algorithms, the interactions between various gene variants could be used to compute ultimate effects on a whole host of physical and mental characteristics beyond disease alone. Computational algorithms could determine the probability of the development of heart disease or asthma or sexual orientation and assign a level of relative risk for various fates to each genome. The genome will thus be read not in absolutes, but in likelihoods-like a report card that does not contain grades but probabilities, or a resume that does not list past experiences but future propensities. It will become a manual for previvorship.

When studies using mental ability test scores from children are considered, the heritability of mental ability is typically found to be about .40, and the effect of the common or shared environment is found to be almost as strong, about .35. In contrast, when studies using mental ability test scores from adults (or older adolescents) are considered, estimates of the heritability of mental ability are much higher, typically about .65, whereas estimates of common or shared environment effects are much lower, probably under .20 (see review by Haworth et al., 2010). These findings indicate that differences among children in their levels of mental ability are attributable almost as much to their common environment—that is, to features of their family or household circumstances—as to their genetic inheritances. However, the findings also suggest that as children grow up, the differences among them in mental ability become less strongly related to the features of their common environments, and more strongly related to their genetic inheritances. In other words, the effect on one's mental ability of the family or household in which one is reared tends to become less important as one grows up, so that by adulthood one's level of mental ability is heavily dependent on one's genetic characteristics. It is as if one's level of mental ability—relative to that of other persons of the same age—can be raised (or lowered) during childhood by a particularly good (or poor) home environment, but then gradually returns to the level that one's genes tend to produce.

Sam’s the man who’s come to chop us up to bits. No wonder I kicked him out. No wonder I changed the locks. If he cannot stop death, what good is he? ‘Open the door. Please. I’m so tired,’ he says. I look at the night that absorbed my life. How am I supposed to know what’s love, what’s fear? ‘If you’re Sam who am I?’ ‘I know who you are.’ ‘You do?’ ‘Yeah.’ ‘Who?’ Don’t say wife, I think. Don’t say mother. I put my face to the glass, but it’s dark. I don’t reflect. Sam and I watch each other through the window of the kitchen door. He coughs some more. ‘I want to come home,’ he says. ‘I want us to be okay. That’s it. Simple. I want to come home and be a family.’ ‘But I am not simple.’ My body’s coursing with secret genes and hormones and proteins. My body made eyeballs and I have no idea how. There’s nothing simple about eyeballs. My body made food to feed those eyeballs. How? And how can I not know or understand the things that happen inside my body? That seems very dangerous. There’s nothing simple here. I’m ruled by elixirs and compounds. I am a chemistry project conducted by a wild child. I am potentially explosive. Maybe I love Sam because hormones say I need a man to kill the coyotes at night, to bring my babies meat. But I don’t want caveman love. I want love that lives outside the body. I want love that lives. ‘In what ways are you not simple?’ I think of the women I collected upstairs. They’re inside me. And they are only a small fraction of the catalog. I think of molds, of the sea, the biodiversity of plankton. I think of my dad when he was a boy, when he was a tree bud. ‘It’s complicated,’ I say, and then the things I don’t say yet. Words aren’t going to be the best way here. How to explain something that’s coming into existence? ‘I get that now.’ His shoulders tremble some. They jerk. He coughs. I have infected him. ‘Sam.’ We see each other through the glass. We witness each other. That’s something, to be seen by another human, to be seen over all the years. That’s something, too. Love plus time. Love that’s movable, invisible as a liquid or gas, love that finds a way in. Love that leaks. ‘Unlock the door,’ he says. ‘I don’t want to love you because I’m scared.’ ‘So you imagine bad things about me. You imagine me doing things I’ve never done to get rid of me. Kick me out so you won’t have to worry about me leaving?’ ‘Yeah,’ I say. ‘Right.’ And I’m glad he gets that. Sam cocks his head the same way a coyote might, a coyote who’s been temporarily confused by a question of biology versus mortality. What’s the difference between living and imagining? What’s the difference between love and security? Coyotes are not moral. ‘Unlock the door?’ he asks. This family is an experiment, the biggest I’ve ever been part of, an experiment called: How do you let someone in? ‘Unlock the door,’ he says again. ‘Please.’ I release the lock. I open the door. That’s the best definition of love. Sam comes inside. He turns to shut the door, then stops himself. He stares out into the darkness where he came from. What does he think is out there? What does he know? Or is he scared I’ll kick him out again? That is scary. ‘What if we just left the door open?’ he asks. ‘Open.’ And more, more things I don’ts say about the bodies of women. ‘Yeah.’ ‘What about skunks?’ I mean burglars, gangs, evil. We both peer out into the dark, looking for thees scary things. We watch a long while. The night does nothing. ‘We could let them in if they want in,’ he says, but seems uncertain still. ‘Really?’ He draws the door open wider and we leave it that way, looking out at what we can’t see. Unguarded, unafraid, love and loved. We keep the door open as if there are no doors, no walls, no skin, no houses, no difference between us and all the things we think of as the night.

I process the information slowly, piece by piece. I’m not Divergent. I’m not like Tris. I’m genetically damaged. The word “damaged” sinks inside me like it’s made of lead. I guess I always knew there was something wrong with me, but I thought it was because of my father, or my mother, and the pain they bequeathed to me like a family heirloom, handed down from generation to generation. And this means that the one good thing my father had—his Divergence—didn’t reach me. I don’t look at Tris—I can’t bear it. Instead I look at Nita. Her expression is hard, almost angry. “Matthew,” she says. “Don’t you want to take this data to your lab to analyze?” “Well, I was planning on discussing it with our subjects here,” Matthew says. “I don’t think that’s a good idea,” Tris says, sharp as a blade. Matthew says something I don’t really hear; I’m listening to the thump of my heart. He taps the screen again, and the picture of my DNA disappears, so the screen is blank, just glass. He leaves, instructing us to visit his lab if we want more information, and Tris, Nita, and I stand in the room in silence. “It’s not that big a deal,” Tris says firmly. “Okay?” “You don’t get to tell me it’s not a big deal!” I say, louder than I mean to be. Nita busies herself at the counter, making sure the containers there are lined up, though they haven’t moved since we first came in. “Yeah, I do!” Tris exclaims. “You’re the same person you were five minutes ago and four months ago and eighteen years ago! This doesn’t change anything about you.” I hear something in her words that’s right, but it’s hard to believe her right now. “So you’re telling me this affects nothing,” I say. “The truth affects nothing.” “What truth?” she says. “These people tell you there’s something wrong with your genes, and you just believe it?” “It was right there.” I gesture to the screen. “You saw it.” “I also see you,” she says fiercely, her hand closing around my arm. “And I know who you are.