Enzymes Related Quotes

How do fields express their principles? Physicists use terms like photons, electrons, quarks, quantum wave functions, relativity, and energy conservation. Astronomers use terms like planets, stars, galaxies, Hubble shift, and black holes. Thermodynamicists use terms like entropy, first law, second law, and Carnot cycle. Biologists use terms like phylogeny, ontology, DNA, and enzymes. Each of these terms can be considered to be the thread of a story. The principles of a field are actually a set of interwoven stories about the structure and behavior of field elements, the fabric of the multiverse.

Young developing leaves on normal trees are often tinged red thanks to a kind of sun block in their delicate tissue. This is anthocyanin, which blocks ultraviolet rays to protect the little leaves. As the leaves grow, the anthocyanin is broken down with the help of an enzyme. A few beeches or maples deviate from the norm because they lack this enzyme. They cannot get rid of the red color, and they retain it even in their mature leaves. Therefore, their leaves strongly reflect red light and waste a considerable portion of the light’s energy. Of course, they still have the blue tones in the spectrum for photosynthesis, but they are not achieving the same levels of photosynthesis as their green-leaved relatives. These red trees keep appearing in Nature, but they never get established and always disappear again. Humans, however, love anything that is different, and so we seek out red varieties and propagate them. One man’s trash is another man’s treasure is one way to describe this behavior, which might stop if people knew more about the trees’ circumstances.

Enzymes have made and unmade every single biomolecule inside every living cell that lives or has ever lived. Enzymes are as close as anything to the vital factors of life. So the discovery that some, and possibly all, enzymes work by promoting the dematerialization of particles from one point in space and their instantaneous materialization in another provides us with a novel insight into the mystery of life. And while there remain many unresolved issues related to enzymes that need to be better understood, such as the role of protein motions, there is no doubt that quantum tunneling plays a role in the way they work. Even so, we should address a criticism made by many scientists who accept the findings of Klinman, Scrutton and others, but nevertheless claim that quantum effects have as relevant a role in biology as they have in the workings of a steam train: they are always there but are largely irrelevant to understanding how either system works. Their argument is often positioned within a debate about whether or not enzymes evolved to take advantage of quantum phenomena such as tunneling. The

Aged garlic extract 600 mg one to three times a day. Aged garlic extract is used to protect the heart and blood vessels, and is reported to help decrease oxidative stress markers, including those related to blood sugar regulation problems. Aged garlic has also been reported to reduce liver enzymes and fatty liver, as well as decrease the formation of advanced glycation end-products (AGEs), which are implicated in various health problems, such as heart disease, kidney problems, and cancer.

LDL-ASSOCIATED PLA2 (PLAC) This blood test measures the level of lipoprotein associated-phospholipase A2 (Lp-PLA2), an enzyme associated with inflammation, stroke, and heart attack risk. However, high levels also may be due to non-arterial causes. Goal values Less than 200 ng/mL (normal value) for low relative risk of CVD Between 200-235 ng/mL for intermediate relative risk of CVD More than 235 ng/mL for high relative risk of CVD

Many people outside Korea subscribe to the belief that Korean food contains mystic healing properties. The SARS bird flu epidemic of 2003 made kimchi ubiquitous throughout Asia. SARs raged throughout China, Southeast Asia, and even Canada and parts of Europe, with about 8,000 reported cases and about 750 deaths. Meanwhile, South Korea experienced zero bird flu–related deaths (there were two cases, both nonfatal). Many theories as to South Korea’s immunity have been postulated; none were conclusive. One study suggested that the enzymes contained in kimchi strengthened immunity in birds; some people made the mental leap to assume that this also protected them from bird flu. Through

Stocks passed my e-mail along to Model Gut senior scientist Richard Faulks. Faulks was dismissive not only of extreme chewing, but also of the related fad for blenderizing to increase the accessibility of nutrients. It’s true saliva carries an enzyme that breaks down starch, but the pancreas makes this enzyme too. So any digestive slack caused by hasty chewing would be taken up in the small intestine. The human digestive tract has evolved to extract the maximum it can from the food ingested, Faulks said, and that is probably all it needs. “Nutritional science is dogged by the idea that if some is good, more is better,

It takes energy to shuttle those nutrients in and out of the bloodstream, to power the enzymes that glue them together (into proteins, triglycerides, and glycogen) and the other enzymes that then break them apart, to fuel the liver during that gluconeogenesis trick.

Instead, complex food matter is broken down into its simplest parts (molecules): amino acids (the building blocks of protein), simple sugars like glucose (the building blocks of more complex sugars and of starches [carbohydrates]), and free fatty acids and glycerol (the constituents of fat). This is accomplished in the gastrointestinal tract by enzymes, chemicals that can degrade more complex molecules. The simple building blocks thus produced are absorbed into the bloodstream for delivery to whichever cells in the body need them.

attacks, I often have them use systemic enzymes. It takes quite a few. I use PanZymes or Wobenzym. There is another one called Vitalzym. I have them use four to six capsules, three times a day, but it really starts reducing the inflammation, which can be the difference between struggling with asthma attacks and leading a relatively normal life.

It’s Thanksgiving, and you’ve eaten with porcine abandon. Your bloodstream is teeming with amino acids, fatty acids, glucose. It’s far more than you need to power you over to the couch in a postprandial daze. What does your body do with the excess? This is crucial to understand because, basically, the process gets reversed when you’re later sprinting for your life. To answer this question, it’s time we talked finances, the works—savings accounts, change for a dollar, stocks and bonds, negative amortization of interest rates, shaking coins out of piggy banks—because the process of transporting energy through the body bears some striking similarities to the movement of money. It is rare today for the grotesquely wealthy to walk around with their fortunes in their pockets, or to hoard their wealth as cash stuffed inside mattresses. Instead, surplus wealth is stored elsewhere, in forms more complex than cash: mutual funds, tax-free government bonds, Swiss bank accounts. In the same way, surplus energy is not kept in the body’s form of cash—circulating amino acids, glucose, and fatty acids—but stored in more complex forms. Enzymes in fat cells can combine fatty acids and glycerol to form triglycerides (table). Accumulate enough of these in the fat cells and you grow plump. Meanwhile, your cells can stick series of glucose molecules together. These long chains, sometimes thousands of glucose molecules long, are called glycogen. Most glycogen formation occurs in your muscles and liver. Similarly, enzymes in cells throughout the body can combine long strings of amino acids, forming them into proteins. The hormone that stimulates the transport and storage of these building blocks into target cells is insulin. Insulin is this optimistic hormone that plans for your metabolic future. Eat

Thyroid tissue disorder related to thyroid peroxidase (TPO) autoimmune response:366 TPO is the enzyme in the thyroid responsible for the production of thyroid hormones and is a common site for autoimmune attacks. A positive TPO antibody test suggests Hashimoto’s disease. Nutritional support Regulatory T-cell Support • Emulsified vitamin D and liposomal glutathione and superoxide dismutase cream. TH-1 response or TH-2 response •     Nutritional compounds to support the TH-1 response. Key ingredients include astragalus root extract, echinacea purpurea root, licorice root extract, porcine thymus gland, lemon balm, maitake mushroom, and pomegranate. •     Nutritional compounds to support the TH-2 response. Key ingredients include pine bark extract, grape seed extract, green tea extract, resveratrol, and pycnogenol. Please work with a qualified healthcare practitioner to safely and correctly use these nutrients in the right amounts.

I monitor several biomarkers related to metabolism, keeping a watchful eye for things like elevated uric acid, elevated homocysteine, chronic inflammation, and even mildly elevated ALT liver enzymes. Lipoproteins, which we will discuss in detail in the next chapter, are also important, especially triglycerides; I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides—all of which may show up many years before a patient would meet the textbook definition of metabolic syndrome. These biomarkers help give us a clearer picture of a patient’s overall metabolic health than HbA1c, which is not very specific by itself.

CHAPTER 6 HOW DO YOU REPAIR EMF-RELATED DAMAGE? I know it may not feel like it at this point in the book, but there is good news here: Now that we have established how EMF exposure can damage your DNA through the peroxynitrite-induced creation of free radicals, we have a framework to remediate the damage. And there is even better news: Although there is no way your ancestral biology could have predicted the enormous exposure you would have to MHz and GHz radiation from the wireless industry, you do indeed have a built-in repair system that can at least partially remediate the damage. It is called the poly (ADP-ribose) polymerase (PARP) family of enzymes. (I know that is a mouthful, but this is a really important group of enzymes.) PARP1 is the most common in the family of 17 PARP enzymes and is best known for its ability to repair DNA damage., Note that in 2019 the PARP1 name was changed to ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1).1 PARP enzymes function as DNA damage sensors and signaling molecules. These enzymes bind to both single- and double-stranded DNA breaks.2

Autophagy is essential to life. If it shuts down completely, the organism dies. Imagine if you stopped taking out the garbage (or the recycling); your house would soon become uninhabitable. Except instead of trash bags, this cellular cleanup is carried out by specialized organelles called lysosomes, which package up the old proteins and other detritus, including pathogens, and grind them down (via enzymes) for reuse. In addition, the lysosomes also break up and destroy things called aggregates, which are clumps of damaged proteins that accumulate over time. Protein aggregates have been implicated in diseases such as Parkinson’s and Alzheimer’s disease, so getting rid of them is good; impaired autophagy has been linked to Alzheimer’s disease–related pathology and also to amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and other neurodegenerative disorders.

I monitor several biomarkers related to metabolism, keeping a watchful eye for things like elevated uric acid, elevated homocysteine, chronic inflammation, and even mildly elevated ALT liver enzymes. Lipoproteins, which we will discuss in detail in the next chapter, are also important, especially triglycerides; I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides—all of which may show up many years before a patient would meet the textbook definition of metabolic syndrome. These biomarkers help give us a clearer picture of a patient’s overall metabolic health than HbA1c, which is not

Oxidation burns things gradually and steadily. Just as oxidation causes metal to rust and apple flesh to brown, it damages cells throughout the body by zapping DNA, scarring the walls of arteries, inactivating enzymes, and mangling proteins. Paradoxically, the more oxygen we use, the more we generate reactive oxygen species, so theoretically vigorous physical activities that consume lots of oxygen should accelerate senescence. A related driver of senescence is mitochondrial dysfunction. Mitochondria are the tiny power plants in cells that burn fuel with oxygen to generate energy (ATP). Cells in energy-hungry organs like muscles, the liver, and the brain can have thousands of mitochondria. Because mitochondria have their own DNA, they also play a role in regulating cell function, and they produce proteins that help protect against diseases like diabetes and cancer.29 Mitochondria, however, burn oxygen, creating reactive oxygen species that, unchecked, cause self-inflicted damage. When mitochondria cease to function properly or dwindle in number, they cause senescence and illness.30

Plasticity of neuroendocrine-thymus interactions during aging N.Fabris12E.Mocchegiani2M.Provinciali2 Abstract Thymic regrowth and reactivation of thymic endocrine activity may be achieved even in old animals by different endocrinological or nutritional manipulations such as, (a) intrathymic transplantation of pineal gland or treatment with melatonin, (b) implantation of a growth hormone (GH) secreting tumor cell line or treatment with exogenous GH, (c) castration or treatment with exogenous luteinizing hormone-releasing hormone (LH-RH), (d) treatment with exogenous thyroxine or triiodothyronine, and (e) nutritional interventions such as arginine or zinc supplementation. These data strongly suggest that thymic involution is a phenomenon secondary to age-related alterations in neuroendocrine-thymus interactions and that it is the disruption of such interactions in old age that is responsible for age-associated dysfunction. Melatonin or other pineal factors may act through specific receptors, but experimental evidence is still lacking. The role of zinc, whose turnover is usually reduced in old age, is diverse. The effects range from the reactivation of zinc-dependent enzymes, required for both cell proliferation and apoptosis, to the reactivation of thymulin, a zinc-dependent thymic hormone. The role of zinc may even be more crucial. According to recent preliminary data obtained both in animal and human studies, it appears that the above reported endocrinological manipulations capable of restoring thymic activity in old age, may act also by normalizing the altered zinc pool.

It was Wu’s deepest perception that the park was fundamentally sound, as he believed his paleo-DNA was fundamentally sound. Whatever problems might arise in the DNA were essentially point-problems in the code, causing a specific problem in the phenotype: an enzyme that didn’t switch on, or a protein that didn’t fold. Whatever the difficulty, it was always solved with a relatively minor adjustment in the next version. Similarly, he knew that Jurassic Park’s problems were not fundamental problems. They were not control problems. Nothing as basic, or as serious, as the possibility of an animal escaping. Wu found it offensive to think that anyone would believe him capable of contributing to a system where such a thing could happen.

Menopause has been linked to the following microbiome changes: REDUCED MICROBIAL DIVERSITY: Menopause and lower estrogen levels have been associated with a decrease in the diversity of the gut microbiome. This decrease can disrupt the delicate balance within the microbiota, potentially leading to health complications. SHIFT TOWARD MALE-LIKE COMPOSITION: Research suggests that menopause may alter the gut microbiome composition, shifting it to be more like the male microbiome. While we don’t know yet how this may correlate to changes in health, menopause-related microbiome alterations have been linked to adverse cardiometabolic profiles, which may include high blood sugar, high cholesterol, and increased waist circumference. ESTROBOLOME POTENTIAL: A new area of research is related to the estrobolome, which is a collection of enzyme-producing genes found in the gut microbiome that allow your gut bacteria to metabolize estrogen. Interestingly, the actions of the estrobolome allow for inactive estrogen to become active again and re-enter the bloodstream. During menopause, there may be a reduction in estrobolome potential, which could affect estrogen metabolism and hormone-related health. Researchers are exploring the potential role of the estrobolome as it relates to estrogen-responsive cancers, and I suspect we’ll be hearing a lot more about it in the future. INCREASED GUT BARRIER PERMEABILITY: The decline in estrogen and progesterone levels during menopause may lead to increased permeability of the gut barrier. Greater permeability can allow bacteria and their by-products to cross into the bloodstream and potentially trigger inflammation

A cascade of stress-related hormones floods the body in response to the sustained exertion. Blood tests after ultras have shown elevated cardiac enzymes, renal injury, and very high levels of the stress hormone cortisol, the proinflammatory compound interleukin-6, and creatine kinase, a toxic byproduct of muscle breakdown. That’s a lot for the immune system to handle. Approximately one in four runners at the Western States gets a cold after the race, and this is in the height of summer! Most