Effects Of Drugs Quotes

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I hate you,” Andrew said casually. He took a last long drag from his cigarette and flicked it off the roof. “You were supposed to be a side effect of the drugs.” “I’m not a hallucination,” Neil said, nonplussed. “You are a pipe dream,” Andrew said.
Nora Sakavic (The King's Men (All for the Game, #3))
Imagine a society that subjects people to conditions that make them terribly unhappy then gives them the drugs to take away their unhappiness. Science fiction It is already happening to some extent in our own society. Instead of removing the conditions that make people depressed modern society gives them antidepressant drugs. In effect antidepressants are a means of modifying an individual's internal state in such a way as to enable him to tolerate social conditions that he would otherwise find intolerable.
Theodore J. Kaczynski
A Short Alternative Medical Dictionary Definitions courtesy of Dr Lemuel Pillmeister (also known as Lemmy) Addiction - When you can give up something any time, as long as it's next Tuesday. Cocaine - Peruvian Marching Powder. A stimulant that has the extraordinary effect that the more you do, the more you laugh out of context. Depression - When everything you laugh at is miserable and you can't seem to stop. Heroin - A drug that helps you to escape reality, while making it much harder to cope when you are recaptured. Psychosis - When everybody turns into tiny dolls and they have needles in their mouths and they hate you and you don't care because you have THE KNIFE! AHAHAHAHAHAHA!
Nikki Sixx (The Heroin Diaries: A Year in the Life of a Shattered Rock Star)
After... The seas have dried out The trains have come to a shrieking holt The hounds of the abyss cease to howl The prisons have closed their doors The pigs have no one to arrest except themselves The drugs no longer have an effect When it's all over All I'll remember is you
Henry Rollins
Bellamy didn’t know why the ancient humans even bothered doing drugs. What was the point of shooting junk into your veins when walking through the forest had the same effect?
Kass Morgan (The Hundred (The Hundred, #1))
Now here's somebody who wants to smoke a marijuana cigarette. If he's caught, he goes to jail. Now is that moral? Is that proper? I think it's absolutely disgraceful that our government, supposed to be our government, should be in the position of converting people who are not harming others into criminals, of destroying their lives, putting them in jail. That's the issue to me. The economic issue comes in only for explaining why it has those effects. But the economic reasons are not the reasons
Milton Friedman
When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.
Michael J. Fox
Every day millions of people decide to grant their smartphone a bit more control over their lives or try a new and more effective antidepressant drug. In pursuit of health, happiness and power, humans will gradually change first one of their features and then another, and another, until they will no longer be human.
Yuval Noah Harari (Homo Deus: ‘An intoxicating brew of science, philosophy and futurism’ Mail on Sunday)
People would be so much more at ease if they acted on impulse rather than reason. That’s why drugs are so effective in curing mental illness—because they impair our judgment. Don’t try to think too much.
Ottessa Moshfegh (My Year of Rest and Relaxation)
The most dramatic instances of directed behavior change and "mind control" are not the consequence of exotic forms of influence, such as hypnosis, psychotropic drugs, or "brainwashing," but rather the systematic manipulation of the most mundane aspects of human nature over time in confining settings.
Philip G. Zimbardo (The Lucifer Effect: Understanding How Good People Turn Evil)
Television, radio, and all the sources of amusement and information that surround us in our daily lives are also artificial props. They can give us the impression that our minds are active, because we are required to react to stimuli from the outside. But the power of those external stimuli to keep us going is limited. They are like drugs. We grow used to them, and we continuously need more and more of them. Eventually, they have little or no effect. Then, if we lack resources within ourselves, we cease to grow intellectually, morally, and spiritually. And we we cease to grow, we begin to die.
Mortimer J. Adler (How to Read a Book: The Classic Guide to Intelligent Reading)
Reason I know, is only a drug, and, as such, its effects are never permanent. But, like the juice of the poppy, it often gives a temporary relief.
Hope Mirrlees (Lud-in-the-Mist)
LSD was an incredible experience. Not that I’m recommending it for anybody else; but for me it kind of – it hammered home to me that reality was not a fixed thing. That the reality that we saw about us every day was one reality, and a valid one – but that there were others, different perspectives where different things have meaning that were just as valid. That had a profound effect on me.
Alan Moore
We all want expanded consciousness and bliss. It's a natural, human desire. And a lot of people look for it in drugs. But the problem is that the body, the physiology, takes a hard hit on drugs. Drugs injure the nervous system, so they just make it harder to get those experiences on your own. I have smoked marijuana, but I no longer do. I went to art school in the 1960s, so you can imagine what was going on. Yet my friends were the ones who said, "No, no, no, David, don't you take those drugs." I was pretty lucky. Besides, far more profound experiences are available naturally. When your consciousness stars expanding, those experiences are there. All those things can be seen. It's just a matter of expanding that ball of consciousness. And the ball of consciousness can expand to be infinite and unbounded. It's totality. You can have totality. So all those experiences are there for you, without the side effects of drugs.
David Lynch (Catching the Big Fish: Meditation, Consciousness, and Creativity)
That is the way convince people. Or change them and prevent them from hurting whether themselves and others. Art is the most effective form of communication. You can use it to lift the human spirit and make them understand that there is more to life than their next drug use.
Jennifer Echols (Going Too Far)
Since I am writing a book about depression, I am often asked in social situations to describe my own experiences, and I usually end by saying that I am on medication. “Still?” people ask. “But you seem fine!” To which I invariably reply that I seem fine because I am fine, and that I am fine in part because of medication. “So how long do you expect to go on taking this stuff?” people ask. When I say that I will be on medication indefinitely, people who have dealt calmly and sympathetically with the news of suicide attempts, catatonia, missed years of work, significant loss of body weight, and so on stare at me with alarm. “But it’s really bad to be on medicine that way,” they say. “Surely now you are strong enough to be able to phase out some of these drugs!” If you say to them that this is like phasing the carburetor out of your car or the buttresses out of Notre Dame, they laugh. “So maybe you’ll stay on a really low maintenance dose?” They ask. You explain that the level of medication you take was chosen because it normalizes the systems that can go haywire, and that a low dose of medication would be like removing half of your carburetor. You add that you have experienced almost no side effects from the medication you are taking, and that there is no evidence of negative effects of long-term medication. You say that you really don’t want to get sick again. But wellness is still, in this area, associated not with achieving control of your problem, but with discontinuation of medication. “Well, I sure hope you get off it sometime soon,” they say.
Andrew Solomon (The Noonday Demon: An Atlas of Depression)
Drugs will have a huge effect on my work for the rest of my life, whether I'm using or not.
Layne Staley
The Right thinks that the breakdown of the family is the source of crime and poverty, and this they very insightfully blame on the homosexuals, which would be amusing were it not so tragic. Families and 'family values' are crushed by grinding poverty, which also makes violent crime and drugs attractive alternatives to desperate young men and sends young women into prostitution. Family values are no less corrupted by the corrosive effects of individualism, consumerism, and the accumulation of wealth. Instead of shouting this from the mountain tops, the get-me-to-heaven-and-the-rest-be-damned Christianity the Christian Right preaches is itself a version of selfish spiritual capitalism aimed at netting major and eternal dividends, and it fits hand in glove with American materialism and greed.
John D. Caputo (What Would Jesus Deconstruct?: The Good News of Postmodernism for the Church (The Church and Postmodern Culture))
The best protection against propaganda of any sort is the recognition of it for what it is. Only hidden and undetected oratory is really insidious. What reaches the heart without going through the mind is likely to bounce back and put the mind out of business. Propaganda taken in that way is like a drug you do not know you are swallowing. The effect is mysterious; you do not know afterwards why you feel or think the way you do.
Mortimer J. Adler (How to Read a Book: The Classic Guide to Intelligent Reading)
I don't know if you realize this, but there are some researchers - doctors - who are giving this kind of drug to volunteers, to see what the effects are, and they're doing it the proper scientific way, in clean white hospital rooms, away from trees and flowers and the wind, and they're surprised at how many of the experiments turn sour. They've never taken any sort of psychedelic themselves, needless to say. Their volunteers - they're called 'subjects,' of course - are given mescaline or LSD and they're all opened up to their surroundings, very sensitive to color and light and other people's emotions, and what are they given to react to? Metal bed-frames and plaster walls, and an occasional white coat carrying a clipboard. Sterility. Most of them say afterward that they'll never do it again.
Alexander Shulgin (Pihkal: A Chemical Love Story)
You will be interested to hear, Hilary, that it [the drug] had a most remarkable effect — even on Selena after a very modest quantity. She cast off all conventional restraints and devoted herself without shame to the pleasure of the moment." I asked for particulars of this uncharacteristic conduct. "She took from her handbag a paperback edition of Pride and Prejudice and sat on the sofa reading it, declining all offers of conversation.
Sarah Caudwell (The Shortest Way to Hades (Hilary Tamar, #2))
but sometimes optimism is the only drug that works. But it’s sadly temporary in its effects.
Rachel Caine (Windfall (Weather Warden, #4))
The more a book is like an opium pipe, the more the Chinaman reader is satisfied with it and tends to discuss the quality of the drug rather than its lethargic effects.
Julio Cortázar (Around the Day in Eighty Worlds)
No one in a productive society wants you to know there ways of looking at the world other than their ways, and among the effects drugs may have is that of switching a mind from the normal track. Reading the works of certain writers has a corresponding effect. When receptive individuals explore the writings of someone such as Lovecraft, they are majestically solaced to find articulations of existence countering those to which the heads around them have become habituated.
Thomas Ligotti (The Conspiracy Against the Human Race)
Thus he spent his whole life searching for his own truth, but it remained hidden to him because he had learned at a very young age to hate himself for what his mother had done to him. (...) But not once did he allow himself to direct his endless, justified rage at the true culprit, the woman who had kept him locked up in her prison for as long as she could. All his life he attempted to free himself of that prison, with the help of drugs, travel, illusions, and above all poetry. But in all these desperate efforts to open the doors that would have led to liberation, one of them remained obstinently shut, the most important one: the door to the emotional reality of his childhood, to the feelings of the little child who was forced to grow up with a severely disturbed, malevolent woman, with no father to protect him from her.
Alice Miller (The Body Never Lies: The Lingering Effects of Hurtful Parenting)
The difference between magic and meditation methods is the difference between drugs and diet—medicines will do swiftly what diet can only effect slowly, and in critical cases there is no time to wait for the slow processes of dietetics, so it must be either medicines or nothing. Nevertheless, drugs are no substitute for right diet and wholesome regime, and although magic enables a speedy and potent result to be attained, is is only by means of right understanding and right ethics that the position which has been won can be held.
Dion Fortune (Esoteric Orders and Their Work and The Training and Work of the Initiate)
Emotions were a drug with their own side effects, ebbs and flows.
Wildbow (Twig)
I stumbled upon Friedrich Nietzsche when I was 17, following the usual trail of existential candies—Camus, Sartre, Beckett—that unsuspecting teenagers find in the woods. The effect was more like a drug than a philosophy. I was whirled upward—or was it downward?—into a one-man universe, a secret cult demanding that you put a gun to the head of your dearest habits and beliefs. That intoxicating whiff of half-conscious madness; that casually hair-raising evisceration of everything moral, responsible and parentally approved—these waves overwhelmed my adolescent dinghy. And even more than by his ideas—many of which I didn't understand at all, but some of which I perhaps grasped better then than I do now—I was seduced by his prose. At the end of his sentences you could hear an electric crack, like the whip of a steel blade being tested in the air. He might have been the Devil, but he had better lines than God.
Gary Kamiya
Everything changed when I met the girl. She penetrated a corner of my soul that had been kept sealed and even I didn't know was there. With her gestures, the scent of her skin, her sudden, intense glances that filled me with overwhelming tenderness, with her dependence that was a kind of unthinking, absolute acceptance, she could rescue me instantly from my confusions and obsessions, my discouragement and failure, or my simple daily routine, and leave me inside a radiant circle made of throbbing energy and powerful certainty, like the effects of an unknown drug that produces unconditional happiness.
Álvaro Mutis (The Adventures and Misadventures of Maqroll)
Because drugs have become so profitable, major medical journals rarely publish studies on nondrug treatments of mental health problems.31 Practitioners who explore treatments are typically marginalized as “alternative.” Studies of nondrug treatments are rarely funded unless they involve so-called manualized protocols, where patients and therapists go through narrowly prescribed sequences that allow little fine-tuning to individual patients’ needs. Mainstream medicine is firmly committed to a better life through chemistry, and the fact that we can actually change our own physiology and inner equilibrium by means other than drugs is rarely considered.
Bessel van der Kolk (The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma)
Mother's hug- The only drug that works every time, costs nothing and has no side effects.
Hassaan Ali
In pharmaceutical speak, psilocybin is known as an asshole inhibitor.
Bill Maher
With all those negative emotions filling her mind and all those stress hormones coursing through her body, no vegetable, supplement, exercise program, or drug was going to be strong enough to counteract the harmful health effects of chronic stress responses on her body.
Lissa Rankin (Mind Over Medicine)
Few see looking after others as therapeutic for the person who does the caretaking, or consider community involvement as therapeutic as drugs. Yet there is mounting evidence that a rich network of face-to-face relationships creates a biological force field against disease.
Susan Pinker (The Village Effect: How Face-to-Face Contact Can Make Us Healthier, Happier, and Smarter)
Depression is a serious problem, but drugs are not the answer. In the long run, psychotherapy is both cheaper and more effective, even for very serious levels of depression. Physical exercise and self-help books based on CBT can also be useful, either alone or in combination with therapy. Reducing social and economic inequality would also reduce the incidence of depression.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
Accepting the fact that she did indeed have Alzheimer's, that she could only bank on two unacceptably effective drugs available to treat it, and that she couldn't trade any of this in for some other, curable disease, what did she want? Assuming the in vitro procedure worked, she wanted to live to hold Anna's baby and know it was her grandchild. She wanted to see Lydia act in something she was proud of. She wanted to see Tom fall in love. She wanted one more sabbatical year with John. She wanted to read every book she could before she could no longer read. She laughed a little, surprised at what she'd just revealed about herself. Nowhere in that list was anything about linguistics, teaching, or Harvard. She ate her last bite of cone. She wanted more sunny, seventy-degree days and ice-cream cones.
Lisa Genova (Still Alice)
Drugs can make you feel high, but it’s temporary.” I wipe the corner of Kir’s mouth. “Love can be temporary, too, but it has an everlasting effect. Sometimes, it becomes hard to breathe or think or even be without it.
Rina Kent (Black Knight (Royal Elite, #4))
Thanks pal, but I tend to avoid any substance that makes me feel smarter, stronger, or better looking than I know I actually am." There were, in his opinion, drugs that diminished ego and drugs that engorged ego, which is to say, revelatory drugs and delusory drugs, and on a psychic level, at least, he favored awe over swagger. Should he ever aspire to become voluntarily delusional, then good old-fashioned alcohol would do the job effectively and inexpensively, thank you, and without the dubious bonus of jaw-clenching jitters.
Tom Robbins (Fierce Invalids Home from Hot Climates)
I also turn to homeopathic remedies for the treatment of indigestion, travel sickness, insomnia and hay fever just to name a few. Homeopathy offers a safe, natural alternative that causes no side effects or drug interactions.
Cindy Crawford
some psychiatrists believe that exercise (aerobic or anaerobic) can be as effective in healing depression as psychotherapy or antidepressant drugs.14
Helen Fisher (Why We Love: The Nature and Chemistry of Romantic Love)
When I went on my first antidepressant it had the side effect of making me fixated on suicide (which is sort of the opposite of what you want). It’s a rare side effect so I switched to something else that did work. Lots of concerned friends and family felt that the first medication’s failure was a clear sign that drugs were not the answer; if they were I would have been fixed. Clearly I wasn’t as sick as I said I was if the medication didn’t work for me. And that sort of makes sense, because when you have cancer the doctor gives you the best medicine and if it doesn’t shrink the tumor immediately then that’s a pretty clear sign you were just faking it for attention. I mean, cancer is a serious, often fatal disease we’ve spent billions of dollars studying and treating so obviously a patient would never have to try multiple drugs, surgeries, radiation, etc., to find what will work specifically for them. And once the cancer sufferer is in remission they’re set for life because once they’ve learned how to not have cancer they should be good. And if they let themselves get cancer again they can just do whatever they did last time. Once you find the right cancer medication you’re pretty much immune from that disease forever. And if you get it again it’s probably just a reaction to too much gluten or not praying correctly. Righ
Jenny Lawson
The consumption of drugs has the effect of reducing men's freedom by circumscribing the range of their interests. It impairs their ability to pursue more important human aims, such as raising a family and fulfilling civic obligations. Very often it impairs their ability to pursue gainful employment and promotes parasitism. Moreover, far from being expanders of consciousness, most drugs severely limit it. One of the most striking characteristics of drug-takers is their intense and tedious self-absorption.
Theodore Dalrymple (Our Culture, What's Left of It: The Mandarins and the Masses)
If I were Satan and wanted to destroy a society, I think I would stage a full blown blitz on its women. I would keep them so distraught and distracted that they would never find the calming strength and serenity for which their sex has always been known. He has effectively done that, catching us in the crunch of trying to be superhuman instead of realistically striving to reach our indiviual purpose and unique God-given potential within such diversity. He tauntingly teases us that if we don't have it all- fame, fortune, families, and fun- and have it every minute all the time, we have been short changed; we are second class citizens in the race of life. You'd have to be deaf, dumb and blind not to get these messages in today's world, and as a sex we are struggling, and our society struggles. Drugs, teenage pregnancies, divorce, family violence, and suicide are some of the every-increasing side effecs of our collective life in the express lane.
Patricia T. Holland (A Quiet Heart)
He was prepared to die for it, as one of Baudelaire's dandies might have been prepared to kill himself in order to preserve himself in the condition of a work of art, for he wanted to make this experience a masterpiece of experience which absolutely transcended the everyday. And this would annihilate the effects of the cruel drug, boredom, to which he was addicted although, perhaps, the element of boredom which is implicit in an affair so isolated from the real world was its principle appeal for him.
Angela Carter (Burning Your Boats: The Collected Short Stories)
Psychedelics show you what’s in and on your mind, those subconscious thoughts and feelings that are are hidden, covered up, forgotten, out of sight, maybe even completely unexpected, but nevertheless imminently present. Depending upon set and setting, the same drug, at the same dose, can cause vastly different responses in the same person. One day, very little happens; another day, you soar, full of ecstatic and insightful discoveries; the next, you struggle through a terrifying nightmare. The generic nature of psychedelic, a term wide open to interpretation, suits these effects.
Rick Strassman
Music was a kind of penetration. Perhaps absorption is a less freighted word. The penetration or absorption of everything into itself. I don't know if you have ever taken LSD, but when you do so the doors of perception, as Aldous Huxley, Jim Morrison and their adherents ceaselessly remind us, swing wide open. That is actually the sort of phrase, unless you are William Blake, that only makes sense when there is some LSD actually swimming about inside you. In the cold light of the cup of coffee and banana sandwich that are beside me now it appears to be nonsense, but I expect you to know what it is taken to mean. LSD reveals the whatness of things, their quiddity, their essence. The wateriness of water is suddenly revealed to you, the carpetness of carpets, the woodness of wood, the yellowness of yellow, the fingernailness of fingernails, the allness of all, the nothingness of all, the allness of nothing. For me music gives access to everyone of these essences, but at a fraction of the social or financial cost of a drug and without the need to cry 'Wow!' all the time, which is LSD's most distressing and least endearing side effects. ...Music in the precision of its form and the mathematical tyranny of its laws, escapes into an eternity of abstraction and an absurd sublime that is everywhere and nowhere at once. The grunt of rosin-rubbed catgut, the saliva-bubble blast of a brass tube, the sweaty-fingered squeak on a guitar fret, all that physicality, all that clumsy 'music making', all that grain of human performance...transcends itself at the moment of its happening, that moment when music actually becomes, as it makes the journey from the vibrating instrument, the vibrating hi-fi speaker, as it sends those vibrations across to the human tympanum and through to the inner ear and into the brain, where the mind is set to vibrate to frequencies of its own making. The nothingness of music can be moulded by the mood of the listener into the most precise shapes or allowed to float as free as thought; music can follow the academic and theoretical pattern of its own modality or adhere to some narrative or dialectical programme imposed by a friend, a scholar or the composer himself. Music is everything and nothing. It is useless and no limit can be set to its use. Music takes me to places of illimitable sensual and insensate joy, accessing points of ecstasy that no angelic lover could ever locate, or plunging me into gibbering weeping hells of pain that no torturer could ever devise. Music makes me write this sort of maundering adolescent nonsense without embarrassment. Music is in fact the dog's bollocks. Nothing else comes close.
Stephen Fry (Moab Is My Washpot (Memoir, #1))
Still another and all-sufficient answer to the argument that the use of spirituous liquors tends to poverty, is that, as a general rule, it puts the effect before the cause. It assumes that it is the use of the liquors that causes the poverty, instead of its being the poverty that causes the use of the liquors.
Lysander Spooner (Vices Are Not Crimes: A Vindication)
Disaster is rarely as pervasive as it seems from recorded accounts. The fact of being on the record makes it appear continuous and ubiquitous whereas it is more likely to have been sporadic both in time and place. Besides, persistence of the normal is usually greater than the effect of the disturbance, as we know from our own times. After absorbing the news of today, one expects to face a world consisting entirely of strikes, crimes, power failures, broken water mains, stalled trains, school shutdowns, muggers, drug addicts, neo-Nazis, and rapists. The fact is that one can come home in the evening--on a lucky day--without having encountered more than one or two of these phenomena. This has led me to formulate Tuchman's Law, as follows: "The fact of being reported multiplies the apparent extent of any deplorable development by five- to tenfold" (or any figure the reader would care to supply).
Barbara W. Tuchman (A Distant Mirror: The Calamitous 14th Century)
This has been a novel about some people who were punished entirely too much for what they did. They wanted to have a good time, but they were like children playing in the street; they could see one after another of them being killed--run over, maimed, destroyed--but they continued to play anyhow. We really all were very happy for a while, sitting around not toiling but just bullshitting and playing, but it was for such a terrible brief time, and then the punishment was beyond belief: even when we could see it, we could not believe it. For example, while I was writing this I learned that the person on whom the character Jerry Fabin is based killed himself. My friend on whom I based the character Ernie Luckman died before I began the novel. For a while I myself was one of these children playing in the street; I was, like the rest of them, trying to play instead of being grown up, and I was punished. I am on the list below, which is a list of those to whom this novel is dedicated, and what became of each. Drug misuse is not a disease, it is a decision, like the decision to step out in front of a moving car. You would call that not a disease but an error in judgment. When a bunch of people begin to do it, it is a social error,a life-style. In this particular life-style the motto is "Be happy now because tomorrow you are dying," but the dying begins almost at once, and the happiness is a memory. It is, then, only a speeding up, an intensifying, of the ordinary human existence. It is not different from your life-style, it is only faster. It all takes place in days or weeks or months instead of years. "Take the cash and let the credit go," as Villon said in 1460. But that is a mistake if the cash is a penny and the credit a whole lifetime. There is no moral in this novel; it is not bourgeois; it does not say they were wrong to play when they should have toiled;it just tells what the consequences were. In Greek drama they were beginning, as a society, to discover science, which means causal law. Here in this novel there is Nemesis: not fate, because any one of us could have chosen to stop playing in the street, but, as I narrate from the deepest part of my life and heart, a dreadful Nemesis for those who kept on playing. I myself,I am not a character in this novel; I am the novel. So, though, was our entire nation at this time. This novel is about more people than I knew personally. Some we all read about in the newspapers. It was, this sitting around with our buddies and bullshitting while making tape recordings, the bad decision of the decade, the sixties, both in and out of the establishment. And nature cracked down on us. We were forced to stop by things dreadful. If there was any "sin," it was that these people wanted to keep on having a good time forever, and were punished for that, but, as I say, I feel that, if so, the punishment was far too great, and I prefer to think of it only in a Greek or morally neutral way, as mere science, as deterministic impartial cause-and-effect. I loved them all. Here is the list, to whom I dedicate my love: To Gaylene deceased To Ray deceased To Francy permanent psychosis To Kathy permanent brain damage To Jim deceased To Val massive permanent brain damage To Nancy permanent psychosis To Joanne permanent brain damage To Maren deceased To Nick deceased To Terry deceased To Dennis deceased To Phil permanent pancreatic damage To Sue permanent vascular damage To Jerri permanent psychosis and vascular damage . . . and so forth. In Memoriam. These were comrades whom I had; there are no better. They remain in my mind, and the enemy will never be forgiven. The "enemy" was their mistake in playing. Let them all play again, in some other way, and let them be happy.
Philip K. Dick (A Scanner Darkly)
The very definition of an addictive drug is one that stimulates the mesolimbic pathway, but there are three general axioms in psychopharmacology that also apply to all drugs: 1. All drugs act by changing the rate of what is already going on. 2. All drugs have side effects. 3. The brain adapts to all drugs that affect it by counteracting the drug’s effects.
Judith Grisel (Never Enough: The Neuroscience and Experience of Addiction)
In a sexual double standard as to who receives consumer protection, it seems that if what you do is done to women in the name of beauty, you may do what you like. It is illegal to claim that something grows hair, or makes you taller, or restores virility, if it does not. It is difficult to imagine that the baldness remedy Minoxidil would be on the market if it had killed nine French and at least eleven American men. In contrast, the long-term effects of Retin-A are still unknown--Dr. Stuart Yusps of the National Cancer Institute refers to its prescription as "a human experiment"--and the Food and Drug Administration has not approved it yet dermatologists are prescribing it to women at a revenue of over $150 million a year.
Naomi Wolf (The Beauty Myth)
From the beginning of high school, all other substances were readily available and liberally consumed by my friends, who used weed and booze like an essential garnish for activities. Peer pressure was rampant with hallucinogens and cocaine. I experimented and hated the effects. Reality wasn’t the problem. I was.
David Poses (The Weight of Air: A Story of the Lies about Addiction and the Truth about Recovery)
Fascism talks ideology, but it is really just marketing—marketing for power. It is recognizable by its need to purge, by the strategies it uses to purge, and by its terror of truly democratic agendas. It is recognizable by its determination to convert all public services to private entrepreneurship, all nonprofit organizations to profit-making ones—so that the narrow but protective chasm between governance and business disappears. It changes citizens into taxpayers—so individuals become angry at even the notion of the public good. It changes neighbors into consumers—so the measure of our value as humans is not our humanity or our compassion or our generosity but what we own. It changes parenting into panicking—so that we vote against the interests of our own children; against their health care, their education, their safety from weapons. And in effecting these changes it produces the perfect capitalist, one who is willing to kill a human being for a product (a pair of sneakers, a jacket, a car) or kill generations for control of products (oil, drugs, fruit, gold).
Toni Morrison (The Source of Self-Regard: Selected Essays, Speeches, and Meditations)
Imagine a society that subjects people to conditions that make them terribly unhappy, then gives them drugs to take away their unhappiness. Science fiction? It is already happening to some extent in our own society. It is well known that the rate of clinical depression has been greatly increasing in recent decades. We believe that this is due to disruption of the power process, as explained in paragraphs 59-76. But even if we are wrong, the increasing rate of depression is certainly the result of SOME conditions that exist in today’s society. Instead of removing the conditions that make people depressed, modern society gives them antidepressant drugs. In effect, antidepressants are a means of modifying an individual’s internal state in such a way as to enable him to tolerate social conditions that he would otherwise find intolerable.
Theodore J. Kaczynski (Industrial Society and Its Future)
When a lobster that has just lost a battle is exposed to serotonin, it will stretch itself out, advance even on former victors, and fight longer and harder.9 The drugs prescribed to depressed human beings, which are selective serotonin reuptake inhibitors, have much the same chemical and behavioural effect. In one of the more staggering demonstrations of the evolutionary continuity of life on Earth, Prozac even cheers up lobsters.
Jordan B. Peterson (12 Rules for Life: An Antidote to Chaos)
Not only are poor, unemployed, less will-educated and non-white people more likely to become depressed, but they are also least likely to benefit from treatment by either antidepressants or psychotherapy. That is why combating depression requires more than merely providing effective treatment for those who are already suffering from it. We also need the change the social conditions - such a racism, unemployment, poverty, unaffordable housing, and lack of adequate education - that put people at increased risk of becoming depressed.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
Like antidepressants, a substantial part of the benefit of psychotherapy depends on a placebo effect, or as Moerman calls it, the meaning response. At least part of the improvement that is produced by these treatments is due to the relationship between the therapist and the client and to the client's expectancy of getting better. That is a problem for antidepressant treatment. It is a problem because drugs are supposed to work because of their chemistry, not because of the psychological factors. But it is not a problem for psychotherapy. Psychotherapists are trained to provide a warm and caring environment in which therapeutic change can take place. Their intention is to replace the hopelessness of depression with a sense of hope and faith in the future. These tasks are part of the essence of psychotherapy. The fact that psychotherapy can mobilize the meaning response - and that it can do so without deception - is one of its strengths, no one of its weaknesses. Because hopelessness is a fundamental characteristic of depression, instilling hope is a specific treatment for it it. Invoking the meaning response is essential for the effective treatment of depression, and the best treatments are those that can do this most effectively and that can do without deception.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
Of course," agreed Basil, "if you read it carelessly, and act on it rashly, with the blind faith of a fanatic; it might very well lead to trouble. But nature is full of devices for eliminating anything that cannot master its environment. The words 'to worship me' are all-important. The only excuse for using a drug of any sort, whether it's quinine or Epsom-salt, is to assist nature to overcome some obstacle to her proper functions. The danger of the so-called habit-forming drugs is that they fool you into trying to dodge the toil essential to spiritual and intellectual development. But they are not simply man-traps. There is nothing in nature which cannot be used for our benefit, and it is up to us to use it wisely. Now, in the work you have been doing in the last week, heroin might have helped you to concentrate your mind, and cocaine to overcome the effects of fatigue. And the reason you did not use them was that a burnt child dreads fire. We had the same trouble with teaching Hermes and Dionysus to swim. They found themselves in danger of being drowned and thought the best way was to avoid going near the water. But that didn't help them to use their natural faculties to the best advantage, so I made them confront the sea again and again, until they decided that the best way to avoid drowning was to learn how to deal with oceans in every detail. It sounds pretty obvious when you put it like that, yet while every one agrees with me about the swimming, I am howled down on all sides when I apply the same principles to the use of drugs.
Aleister Crowley (Diary of a Drug Fiend)
social media addict? This is a very real problem—so much so that researchers from Norway developed a new instrument to measure Facebook addiction called the Bergen Facebook Addiction Scale.[3] Social media has become as ubiquitous as television in our everyday lives, and this research shows that multitasking social media can be as addictive as drugs, alcohol, and chemical substance abuse. A large number of friends on social media networks may appear impressive, but according to a new report, the more social circles a person is linked to, the more likely the social media will be a source of stress.[4] It can also have a detrimental effect on consumer well-being because milkshake-multitasking interferes with clear thinking and decision-making, which lowers self-control and leads to rash, impulsive buying and poor eating decisions. Greater social media use is associated with a higher body mass index, increased binge eating, a lower credit score, and higher levels of credit card debt for consumers with many close friends in their social network—all caused by a lack of self-control.[5] We Can Become Shallow
Caroline Leaf (Switch On Your Brain: The Key to Peak Happiness, Thinking, and Health)
One of the most important things the early LSD pioneers discovered is that the personality of the researcher administering the drug had a profound effect on the experience of the patient. If the examiner was cold and distant, the subject occasionally became hostile, even paranoid. The subjects of a warm and gentle researcher almost universally experienced feelings of love and joy.
Ayelet Waldman (A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My Life)
Bear in mind that since medications do not fix anything, they allow the underlying problem to continue uncorrected and actually accelerate. Meanwhile, new symptoms and new seemingly unrelated diseases are the inevitable consequence of this biochemical faux pas. Furthermore, drug side effects are the leading cause of death. NSAIDs as an example of only one group of medications, are fatally toxic to thousands of people each year by damaging joints, lungs, kidneys, eyes, hearts, and intestines. And they are covered by insurance. You and your doctor have been screwed into believing every symptom is a deficiency of some drug or surgery. You've been led to believe you have no control, when in truth you're the one who must take control. Unfortunately, the modus operandi in medicine is to find a drug to turn off the damaged part that is producing symptoms.
Sherry A. Rogers (Detoxify or Die)
I felt the sun before I saw it. I was dislodging a stubborn ice clump when suddenly my vision snapped off and a sizzling feeling filled my skin. In another instant I could see again, and the landscape—the frozen fjord, the mountains behind the school—caught like a candlewick and exploded around me in a blaze of white fire. The dogs fell still and my throat choked shut, and then they were howling and I was laughing, and in another minute the day was over and the sun sank back down as if it had never been. My ecstasy was illogical, uncontrollable; I felt as if I’d been slipped a drug, and could no more control its chemical effects than I could force the sun to resurface.
Blair Braverman (Welcome to the Goddamn Ice Cube: Chasing Fear and Finding Home in the Great White North)
Because alcohol is primarily a depressant, we reach for it to take the edge off. Which it does, initially. However, the counteractive process (or the B process) to the depressant nature of alcohol is a release of cortisol and adrenaline into the body. If you drink one glass of wine, you might have about twenty minutes of the desired “relaxed” effect before the drug (A process) wears off, and you’re left with increased amounts of cortisol and adrenaline, which fuel anxiety. This means alcohol causes anxiety; it doesn’t manage it.
Holly Whitaker (Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol)
LSD reveals the whatness of things, their quiddity, their essence. The wateriness of water is suddenly revealed to you, the carpetness of carpets, the woodness of wood, the yellowness of yellow, the fingernailness of fingernails, the allness of all, the nothingness of all, the allness of nothing. For me music gives access to every one of these essences of existence, but at a fraction of the social or financial cost of a drug and without the need to cry "Wow!" all the time, which is one of LSD's most distressing and least endearing side-effects.
Stephen Fry (Moab Is My Washpot (Memoir, #1))
The music was intended to replicate or even enhance the mind-altering experiences of the psychedelic drugs. They were using electric guitars, wah-wah pedals, loop music to create ostinato patterns, electric organs, synthesizers (nobody even had any idea what that was at the time, but it was cool to throw it into a conversation), electro-mechanical polyphonic tape replay keyboards, fuzz box effects, backward tapes, you name it. Anything went
Karl Wiggins (Wrong Planet - Searching for your Tribe)
Side effects of those very same prescription drugs are the third leading cause of death, behind heart disease and cancer. That’s right! Prescription drugs kill more people than traffic accidents. According to Dr. Barbara Starfield, writing in the Journal of the American Medical Association in 2000, “adverse effects of medications” (from drugs that were correctly prescribed and taken) kill 106,000 people per year.5 And that doesn’t include accidental overdoses.
T. Colin Campbell (Whole: Rethinking the Science of Nutrition)
While humans have the propensity to develop a suite of prosocial behaviors, they are also capable of developing antisocial behavior, engaging in substance abuse, experiencing depression, and bearing children at an early age...Young people who develop aggressive behavior tendencies are likely to develop problems with tobacco, alcohol, and other drug use; to fail academically; to have children at an early age; and to raise children likely to have the same problems.
Anthony Biglan (The Nurture Effect: How the Science of Human Behavior Can Improve Our Lives and Our World)
But love’s not just the drug; it’s also the dealer. Love wants love in return, am I right, Olly? Like drugs, the highs look divine, and I envy the users. But when the side effects kick in—jealousy, the rages, grief, I think, Count me out. Elizabethans equated romantic love with insanity. Buddhists view it as a brat throwing a tantrum at the picnic of the calm mind.
David Mitchell (The Bone Clocks)
So what steps can a regulator take when it has established that there is a problem? In very extreme cases it can remove a drug from the market (although in the US, technically drugs usually stay on the market, with the FDA advising against their use). More commonly it will issue a warning to doctors through one of its drug safety updates, a ‘Dear Doctor’ letter, or by changing the ‘label’ (confusingly, in reality, a leaflet) that comes with the drug. Drug-safety updates are sent to most doctors, though it’s not entirely clear whether they are widely read. But, amazingly, when a regulator decides to notify doctors about a side effect, the drug company can contest this, and delay the notice being sent out for months, or even years.
Ben Goldacre (Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients)
Research has shown that the more connected we are socially, the longer we will live and the faster we will recover when we get ill. In truth, isolation and loneliness puts us at a greater risk for early disease and death than smoking. Authentic social connection has a profound effect on your mental health—it even exceeds the value of exercise and ideal body weight on your physical health. It makes you feel good. Social connection triggers the same reward centers in your brain that are triggered when people do drugs, or drink alcohol, or eat chocolate. In other words, we get sick alone, and we get well together.
James R. Doty (Into the Magic Shop: A Neurosurgeon's Quest to Discover the Mysteries of the Brain and the Secrets of the Heart)
One day in my pharmacology class, we were discussing the possibility of legalizing marijuana. The class was pretty evenly divided between those that advocated legalizing marijuana and those that did not. The professor said he wanted to hear from a few people on both sides of the argument. A couple students had the opportunity to stand in front of the class and present their arguments. One student got up and spoke about how any kind of marijuana use was morally wrong and how nobody in the class could give him any example of someone who needed marijuana. A small girl in the back of the classroom raised her hand and said that she didn’t want to get up, but just wanted to comment that there are SOME situations in which people might need marijuana. The same boy from before spoke up and said that she needed to back up her statements and that he still stood by the fact that there wasn’t anyone who truly needed marijuana. The same girl in the back of the classroom slowly stood up. As she raised her head to look at the boy, I could physically see her calling on every drop of confidence in her body. She told us that her husband had cancer. She started to tear up, as she related how he couldn’t take any of the painkillers to deal with the radiation and chemotherapy treatments. His body was allergic and would have violent reactions to them. She told us how he had finally given in and tried marijuana. Not only did it help him to feel better, but it allowed him to have enough of an appetite to get the nutrients he so desperately needed. She started to sob as she told us that for the past month she had to meet with drug dealers to buy her husband the only medicine that would take the pain away. She struggled every day because according to society, she was a criminal, but she was willing to do anything she could to help her sick husband. Sobbing uncontrollably now, she ran out of the classroom. The whole classroom sat there in silence for a few minutes. Eventually, my professor asked, “Is there anyone that thinks this girl is doing something wrong?” Not one person raised their hand.
Daniel Willey
Human beings are walking bundles of cravings. Cravings for food, water, shelter, warmth; sex and companionship; status, a tribe to belong to; kicks, control, purpose; and so on, all the way down toe chocolate-brown bathroom suites. Love is one way to satisfy some of these cravings. But love's not just the drug; it's also the dealer. Love wants love in return. Like drugs, the highs look divine, and I envy the users. But when the side effects kick in - jealousy, the rages, grief, I think: Count me out. Elizabethans equated romantic love with insanity, Buddhists view it as a brat throwing a tantrum at the picnic of the calm mind.
David Mitchell (The Bone Clocks)
The placebo effect is well documented and not even very mysterious. Dummy pills, with no pharmacological activity at all, demonstrably improve health. That is why double-blind drug trials must use placebos as controls. It’s why homoeopathic remedies appear to work, even though they are so dilute that they have the same amount of active ingredient as the placebo control—zero molecules.
Richard Dawkins (The God Delusion)
The hardest cases, I think--perhaps the most dangerous ones--are the friends of the Laffertys' (the evil ones). People like Sargeant Ahearn, who has possibly known for years about what goes on in Kensington. And he'll never be fired, never be questioned, never even be disciplined. He'll go on with his daily routine, showing up for work, casually abusing his power in ways that will have lasting effects on individuals and communities, on the whole city of Philadelphia, for years. It's the Ahearns of the world who scare me.
Liz Moore (Long Bright River)
the media, at least in the U.S., tends to focus on pain pill use, abuse, and addiction by people who do not have chronic pain. Even if these stories offhandedly mention that these pills are used to treat pain in people whose physical pain does not go away, however, the stories of those who use pain medicine responsibly -- or, worse, accused of drug-seeking behavior because they need certain types of pills for chronic pain -- are usually overshadowed by the “How can we prevent pain pill addiction?” concern, instead of asking, “How can we treat chronic pain more effectively?
Anna Hamilton
The drug dealer leaned forward and covered his mouth conspiratorily with the back of his hand. In a voice softer than a gust of wind, he said: ‘Got some new merch, though. High tech, top of the line. Muy experimental. Packs quite the punch they say, and hits you like a brick wall, espiritualmente,’ he pushed three fingers together and planted them a kiss. ‘Real sweet. Un dragón muy poderoso.’ ‘Any... particular side-side-side-effects?’ Mario scratched his chin, thinking back on his aggresive nosebleeds. ‘Not a dicky bird,’ affirmed the dealer. ‘This stuff’s cleaner than la cocina de tu abuela. Mind you, it does call for some weird shit, no doubt about it. And you gotta watch yourself for sharp table corners and the lot, cause you WILL be tripping.
Louise Blackwick (The Underworld Rhapsody)
For people who are depressed, and especially for those who do not receive enough benefit from medication of for whom the side effects of antidepressants are troubling, the fact that placebos can duplicate much of the effects of antidepressants should be taken as good news. It means that there are other ways of alleviating depression. As we have seen, treatments like psychotherapy and physical exercise are at least as effective as antidepressant drugs and more effective than placebos. In particular, CBT has been shown to lower the risk of relapsing into depression for years after treatment has ended, making it particularly cost effective.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
The most effective cross-examination of Linda Kasabian was surprisingly that of Ronald Hughes. Though this was his first trial, and he frequently made procedural mistakes, Hughes was familiar with the hippie subculture, having been a part of it. He knew about drugs, mysticism, karma, auras, vibrations, and when he questioned Linda about these things, he made her look just a little odd, just a wee bit zingy. He had her admitting that she believed in ESP, that there were times at Spahn when she actually felt she was a witch. Q. "Do you feel that you are controlled by Mr. Manson's vibrations?" A. "Possibly." Q. "Did he put off a lot of vibes?" A. "Sure, he's doing it right now." Hughes "May the record reflect, Your Honor, that Mr. Manson is merely sitting here." Kanarek "He doesn't seem to be vibrating.
Vincent Bugliosi (Helter Skelter: The True Story of the Manson Murders)
People who live with ADHD are at high risk of addiction, especially adolescents, because of their poorly functioning frontal lobes. Years ago, when the illness was less well understood, doctors and parents were reluctant to give these vulnerable children addictive drugs such as Ritalin and amphetamine. It sounded reasonable: don’t give addictive substances to people at risk for addiction. But rigorous testing showed unambiguously that adolescents who were treated with stimulant drugs were less likely to develop addictions. In fact, those who started the drug at the youngest age and took the highest doses were the least likely to develop problems with illicit drugs. Here’s why: if you strengthen the dopamine control circuit, it’s a lot easier to make wise decisions. On the other hand, if effective treatment is withheld, the weakness of the control circuit is not corrected. The desire circuit acts unopposed, increasing the likelihood of high-risk, pleasure-seeking behavior.
Daniel Z. Lieberman (The Molecule of More: How a Single Chemical in Your Brain Drives Love, Sex, and Creativity―and Will Determine the Fate of the Human Race)
You have a hearing problem," Andrew deduced. "Too many balls to the helmet, perhaps. Can you read lips?" Andrew pointed at his mouth as he spoke. "The next time someone comes for you, stand down and let me deal with it. Do you understand?" "If it means losing you, then no," Neil said. "I hate you," Andrew said casually. He took a last long drag from his cigarette and flicked it off the roof. "You were supposed to be a side effect of the drugs." "I'm not a hallucination," Neil said, nonplussed. "You are a pipe dream," Andrew said. "Go inside and leave me alone." "You still have my keys," Neil reminded him. Andrew dug Neil's keys out of his pocket and pried his car key off it.
Nora Sakavic (The King's Men (All for the Game, #3))
Dr. Margaret Chan, Director-General of the World Health Organization, recently warned that we may be facing a future in which many of our miracle drugs no longer work. She stated, “A post-antibiotic era means, in effect, an end to modern medicine as we know it. Things as common as strep throat or a child’s scratched knee could once again kill.”147 We may soon be past the age of miracles. The director-general’s prescription to avoid this catastrophe included a global call to “restrict the use of antibiotics in food production to therapeutic purposes.” In other words, only use antibiotics in agriculture to treat sick animals. But that isn’t happening. In the United States, meat producers feed millions of pounds of antibiotics each year to farm animals just to promote growth or prevent disease in the often cramped, stressful, and unhygienic conditions of industrial animal agriculture. Yes, physicians overprescribe antibiotics as well, but the FDA estimates that 80 percent of the antimicrobial drugs sold in the United States every year now go to the meat industry.
Michael Greger (How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease)
the kids who can’t adapt to school’s tedium are diagnosed with ADHD and are put on powerful psychoactive drugs, which have the immediate effect of reducing their spontaneity so they can attend to the teacher and complete the senseless busywork. Nobody knows the long-term effects of these drugs on the human brain, but research with animals suggests that one effect may be to interfere with the normal development of the brain connections that lead children generally to become more controlled, less impulsive, with age and maturity.13 Perhaps that helps to explain why today we see more and more cases of ADHD extending into adulthood. As with lots of psychoactive drugs, the drugs used to treat ADHD may be creating long-term dependency.
Peter O. Gray (Free to Learn: Why Unleashing the Instinct to Play Will Make Our Children Happier, More Self-Reliant, and Better Students for Life)
Our analyses of the FDA data showed relatively little difference between the effects of antidepressants and the effects of placebos. Indeed, the effects were so small that they did not qualify as clinically significant. The drug companies knew how small the effect of their medications were compared to placebos, and so did the FDA and other regulatory agencies. The companies found various ways to make the data seem more favorable to their products, and the FDA helped them keep their negative data secret. In fact, in some instances, the FDA urged the companies to keep negative data hidden, even when the companies wanted to reveal them. My colleagues and I hadn't really discovered anything new. We had merely revealed their 'dirty little secret'.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
Psychotherapy works for the treatment of depression, and the benefits are substantial. In head-to-head comparisons, in which the short-term effects of psychotherapy and antidepressants are pitted against each other, psychotherapy works as well as medication. This is true regardless of how depressed the person is to begin with. Psychotherapy looks even better when its long-term effectiveness is assessed. Formerly depressed patients are far more likely to relapse and become depressed again after treatment with antidepressants than they are after psychotherapy. As a result, psychotherapy is significantly more effective than medication when measured some time after treatment has ended, and the more time that has passed since the end of treatment, the larger the difference between drugs and psychotherapy.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
The first time I heard Robert Anda present the results of the ACE study, he could not hold back his tears. In his career at the CDC he had previously worked in several major risk areas, including tobacco research and cardiovascular health. But when the ACE study data started to appear on his computer screen, he realized that they had stumbled upon the gravest and most costly public health issue in the United States: child abuse. He had calculated that its overall costs exceeded those of cancer or heart disease and that eradicating child abuse in America would reduce the overall rate of depression by more than half, alcoholism by two-thirds, and suicide, IV drug use, and domestic violence by three-quarters. 20 It would also have a dramatic effect on workplace performance and vastly decrease the need for incarceration.
Bessel van der Kolk (The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma)
The paradox of being a professional artist. How we spend our lives trying to express ourselves well, but we have nothing to tell. We want creativity to be a system of cause and effect. Results. Marketable product. We want dedication and discipline to equal recognition and reward. We get on our art school treadmill, our graduate program for a master's in fine arts, and practice, practice, practice. With all our excellent skills, we have nothing special to document. .... Nothing pisses us off more than when some strung-out drug addict, a lazy bum, or a slobbering pervert creates a masterpiece. As if by accident. Some idiot who's not afraid to say what they really love.
Chuck Palahniuk (Diary)
It was obvious that a substance with such fantastic effects on mental perception and on the experience of the outer and inner world would also arouse interest outside medical science, but I had not expected that LSD, with its unfathomably uncanny, profound effects, so unlike the character of a recreational drug, would ever find worldwide use as an inebriant. I had expected curiosity and interest on the part of artists outside of medicine—performers, painters, and writers—but not among people in general. After the scientific publications around the turn of the century on mescaline—which, as already mentioned, evokes psychic effects quite like those of LSD—the use of this compound remained confined to medicine and to experiments within artistic and literary circles. I had expected the same fate for LSD. And indeed, the first non-medicinal self-experiments with LSD were carried out by writers, painters, musicians, and other intellectuals.
Albert Hofmann (LSD: My Problem Child – Reflections on Sacred Drugs, Mysticism and Science)
In 1970, I wrote in the New York Times, of all uncongenial places, It is possible to stop most drug addiction in the United States within a very short time. Simply make all drugs available and sell them at cost. Label each drug with a precise description of what effect—good or bad—the drug will have on the taker. This will require heroic honesty. Don’t say that marijuana is addictive or dangerous when it is neither, as millions of people know—unlike “speed,” which kills most unpleasantly, or heroin, which can be addictive and difficult to kick. Along with exhortation and warning, it might be good for our citizens to recall (or learn for the first time) that the United States was the creation of men who believed that each person has the right to do what he wants with his own life as long as he does not interfere with his neighbors’ pursuit of happiness (that his neighbor’s idea of happiness is persecuting others does confuse matters a bit).
Gore Vidal (Perpetual War for Perpetual Peace)
Depression is partly a nocebo effect, in the sense that it can be produced by negative exceptions about oneself and the world. The way in which these negative expectations develop and produce their negative effects provides some clues as to how they can be reversed. Expectancy effects grow, feeding upon themselves. One reason this happens is that our subjective states - our feelings, our moods and sensations - are in constant flux, changing from day to day and from moment to moment. The effects of these fluctuations depend on how we interpret them, and our interpretations depend on our beliefs and expectations. When we expect to feel worse, we tend to notice random small negative changes and interpret them as evidence that we are in fact getting worse. This interpretation makes us actually feel worse, and it strengthens the belief that we are getting worse, leading to a vicious cycle in which our expectations and negative emotions feed on each other, cascading into a full-blown depressive episode. .. Positive expectancies have the opposite effect. They can set in motion a begin cycle, in which random fluctuations in mood and well being are interpreted as evidence of treatment effectiveness, thereby instilling a further sense of hope and countering the feeling of hopelessness that are so central to clinical depression.
Irving Kirsch (The Emperor's New Drugs: Exploding the Antidepressant Myth)
The psychoanalyst Erik H. Erikson devoted a chapter in his Pulitzer Prize—winning book, Childhood and Society, to his reflections on the American identity. “This dynamic country,” he wrote, “subjects its inhabitants to more extreme contrasts and abrupt changes during a generation than is normally the case with other great nations.” Such trends have only accelerated since Erikson made that observation in 1950. The effects of rapid social and economic shifts on the parenting environment are too well known to need detailing here. The erosion of community, the breakdown of the extended family, the pressures on marriage relationships, the harried lives of nuclear families still intact and the growing sense of insecurity even in the midst of relative wealth have all combined to create an emotional milieu in which calm, attuned parenting is becoming alarmingly difficult. The result being successive generations of children in alienation, drug use and violence — what Robert Bly has astutely described as “the rage of the unparented.” Bly notes in The Sibling Society that “in 1935 the average working man had forty hours a week free, including Saturday. By 1990, it was down to seventeen hours. The twenty-three lost hours of free time a week since 1935 are the very hours in which the father could be a nurturing father, and find some center in himself, and the very hours in which the mother could feel she actually has a husband.” These patterns characterize not only the earlyyears of parenting, but entire childhoods. “Family meals, talks, reading together no longer take place,” writes Bly. “What the young need — stability, presence, attention, advice, good psychic food, unpolluted stories — is exactly what the sibling society won’t give them.
Gabor Maté (Scattered: How Attention Deficit Disorder Originates and What You Can Do About It)
One might go to the bakery, perhaps," he said. "But did you know the baker has tuberculosis? All the people here run around in a highly infectious state. The baker's daughter has tuberculosis too, it seems to have something to do with the runoff from the cellulose factory, with the steam that the locomotives have spewed out for decades, with the bad diet that people eat. Almost all of them have cankered lung lobes, pneumothorax and pneumoperitoneum are endemic. They have tuberculosis of the lungs, the head, the arms and legs. All of them have tubercular abscesses somewhere on their bodies. The valley is notorious for tuberculosis. You will find every form of it here: skin tuberculosis, brain tuberculosis, intestinal tuberculosis. Many cases of meningitis, which is deadly within hours. The workmen have tuberculosis from the dirt they dig around in, the farmers have it from their dogs and the infected milk. The majority of the people have galloping consumption. Moreover," he said, "the effect of the new drugs, of streptomycin for example, is nil. Did you know the knacker has tuberculosis? That the landlady has tuberculosis? That the landlady has tuberculosis? That her daughters have been to sanatoria on three occasions? Tuberculosis is by no means on the way out. People claim it is curable. but that's what the pharmaceutical industry says. In fact, tuberculosis is as incurable as it always was. Even people who have been inoculated against it come down with it. Often those who have it the worst are the ones who look so healthy that you wouldn't suspect they were ill at all. Their rosy faces are utterly at variance with their ravaged lungs. You keep running into people who've had to endure a cautery or, at the very least, a transverse lesion. Most of them have had their lives ruined by failed reconstructive surgery." We didn't go to the bakery. Straight home instead.
Thomas Bernhard (Frost)
including salutary effects on the following: • major depression • drug addiction • binge eating • smoking cessation • stress among cancer patients • loneliness among senior citizens • ADHD • asthma • psoriasis • irritable bowel syndrome Studies also indicated that meditation reduced levels of stress hormones, boosted the immune system, made office workers more focused, and improved test scores on the GRE. Apparently mindfulness did everything short of making you able to talk to animals and bend spoons with your mind. This research boom got its start with a Jew-Bu named Jon Kabat-Zinn, a Manhattan-raised, MIT-trained microbiologist who claimed to have had an elaborate epiphany—a “vision,” he called it—while on a retreat in 1979. The substance of the vision was that he could bring meditation to a much broader audience by stripping it of Buddhist metaphysics. Kabat-Zinn designed something called Mindfulness Based Stress Reduction (MBSR), an eight-week course that taught secularized meditation to tens of thousands of people around America and the world. Having a simple, replicable meditation protocol made it easy to test the effects on patients.
Dan Harris (10% Happier)
Migraines are described as “one of the most common” pain syndromes, affecting as much as 12 percent of the population.63 That’s common? How about menstrual cramps, which plague up to 90 percent of younger women?64 Can ginger help? Even just one-eighth of a teaspoon of ginger powder three times a day dropped pain from an eight to a six on a scale of one to ten, and down further to a three in the second month.65 And these women hadn’t been taking ginger all month; they started the day before their periods began, suggesting that even if it doesn’t seem to help much the first month, women should try sticking with it. What about the duration of pain? A quarter teaspoon of ginger powder three times a day was found to not only drop the severity of menstrual pain from about seven down to five but decrease the duration from a total of nineteen hours in pain down to about fifteen hours,66 significantly better than the placebo, which were capsules filled with powdered toast. But women don’t take bread crumbs for their cramps. How does ginger compare to ibuprofen? Researchers pitted one-eighth of a teaspoon of powdered ginger head-to-head against 400 mg of ibuprofen, and the ginger worked just as effectively as this leading drug.67 Unlike the drug, ginger can also reduce the amount of menstrual bleeding, from around a half cup per period down to a quarter cup.68 What’s more, ginger intake of one-eighth of a teaspoon twice daily started a week before your period can yield a significant drop in premenstrual mood, physical, and behavioral symptoms.69 I like sprinkling powdered ginger on sweet potatoes or using it fresh to make lemon-ginger apple chews as an antinausea remedy. (Ever since I was a little kid, I’ve suffered from motion sickness.) There is an array of powerful antinausea
Michael Greger (How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease)
Dear lady, ... dear gentleman, reader, [it's] not right ... to put down this writer on his writing ... And I'll tell you why, too: it hurts, that's why.... People try to understand why writers commit suicide by jumping off boats or by alcoholism or by being heroic continuously or by rope or gun or drug or knife or water, and ... I can tell you straight out, ... it is reading slurring remarks about their writing that drives writers to the grave. Dirty remarks passed by ... dirty but damned nicely educated and very highly-paid ladies and gentlemen have the effect of killing writers. Yes, that's right. Dirty words ... in slick paper magazines read by smart people do assassinate writers. ... And boy let me tell you I am all for it, even when by some ... misunderstanding the dirty words are directed to me rather than to the party really deserving them. Accidents happen, dear clever reviewer or critic, and let it not be said that William Saroyan is one not to see a situation from the point of view of the other party, ... and I shall be the first to defend your right to be critical and even sarcastic, knowing full well that it is not about me and my writing, although my name is by mistake taken in vain by you. ... But go on, go on, do your good clever writing, every one of you, I am home, your are home, and we are each of us not yet on Variety's Necrology list, so if we can't take it, who can?
William Saroyan
A system of justice does not need to pursue retribution. If the purpose of drug sentencing is to prevent harm, all we need to do is decide what to do with people who pose a genuine risk to society or cause tangible harm. There are perfectly rational ways of doing this; in fact, most societies already pursue such policies with respect to alcohol: we leave people free to drink and get inebriated, but set limits on where and when. In general, we prosecute drunk drivers, not inebriated pedestrians. In this sense, the justice system is in many respects a battleground between moral ideas and evidence concerning how to most effectively promote both individual and societal interests, liberty, health, happiness and wellbeing. Severely compromising this system, insofar as it serves to further these ideals, is our vacillation or obsession with moral responsibility, which is, in the broadest sense, an attempt to isolate the subjective element of human choice, an exercise that all too readily deteriorates into blaming and scapegoating without providing effective solutions to the actual problem. The problem with the question of moral responsibility is that it is inherently subjective and involves conjecture about an individuals’ state of mind, awareness and ability to act that can rarely if ever be proved. Thus it involves precisely the same type of conjecture that characterizes superstitious notions of possession and the influence of the devil and provides no effective means of managing conduct: the individual convicted for an offence or crime considered morally wrong is convicted based on a series of hypotheses and probabilities and not necessarily because he or she is actually morally wrong. The fairness and effectiveness of a system of justice based on such hypotheses is highly questionable particularly as a basis for preventing or reducing drug use related harm. For example, with respect to drugs, the system quite obviously fails as a deterrent and the system is not organised to ‘reform’ the offender much less to ensure that he or she has ‘learned a lesson’; moreover, the offender does not get an opportunity to make amends or even have a conversation with the alleged victim. In the case of retributive justice, the justice system is effectively mopping up after the fact. In other words, as far as deterrence is concerned, the entire exercise of justice becomes an exercise based on faith, rather than one based on evidence.
Daniel Waterman (Entheogens, Society and Law: The Politics of Consciousness, Autonomy and Responsibility)
Prostitution clearly promotes the depersonalisation of sex, which can never be good news for women—any women. Prostitution has a ripple effect. It creates the illusory view in the minds of men that women are not human beings as men are, but simply the walking carrier of a product, and that they serve one principal function, whether or not they are paid for it, which is to be used as vessels for the sexual release of men. They are effortlessly and imperceptibly relegated from the realms of the human. They are not people on a par with their male counterparts. How could they be, when their principal function is as something to be fucked? Prostitution obscures women’s humanity from society generally, but it also causes women specifically to lose sensitivity to their own humanity by way of tolerating the prostitution of others of their gender. When women tolerate prostitution they are actually tolerating the dehumanisation of their own gender in a broader and more encompassing sense. Countries with male-majority governments are implementing the legalisation of prostitution with frightening rapidity throughout the western world. Where is the female revolt towards all this? There is no widespread female revolt because female sexuality has so long been viewed as a commodity that woman have begun to believe in the necessity of a separate class of women to provide it. If a woman tolerates this treatment of her fellow women, if she accepts it under the banner of ‘liberalism’ or anything else, then she must also accept that she herself is only removed from prostitution by lack of the circumstances necessary to place her there. Should these circumstances ever occur, her body, too, would be just as welcome for mauling, sucking and fucking by the clients of the brothels and would be just as reviled by the men who are on the look-out for a wife. The acceptance of prostitution makes all women potential prostitutes in the public view since there are only two requirements for a woman to work in a brothel: one is that circumstance has placed her so (and who knows when that can happen, to any of us?) and the other is that she has a vagina, and all women are born meeting at least one of these requirements. It bears repeating: if the commodification of women is to be accepted then all women fall under that potential remit. If a woman accepts prostitution in society, then she accepts this personal indenture, whether she knows it or not; and yes, that is a loss. As
Rachel Moran (Paid For – My Journey through Prostitution: Surviving a Life of Prostitution and Drug Addiction on Dublin's Streets)
The researchers tried a clever tactic to overcome this problem. They created a number of recipes for common foods including muffins and pasta in which they could disguise placebo ingredients like bran and molasses to match the texture and color of the flax-laden foods. This way, they could randomize people into two groups and secretly introduce tablespoons of daily ground flaxseeds into the diets of half the participants to see if it made any difference. After six months, those who ate the placebo foods started out hypertensive and stayed hypertensive, despite the fact that many of them were on a variety of blood pressure pills. On average, they started the study at 155/81 and ended it at 158/81. What about the hypertensives who were unknowingly eating flaxseeds every day? Their blood pressure dropped from 158/82 down to 143/75. A seven-point drop in diastolic blood pressure may not sound like a lot, but that would be expected to result in 46 percent fewer strokes and 29 percent less heart disease over time.125 How does that result compare with taking drugs? The flaxseeds managed to drop subjects’ systolic and diastolic blood pressure by up to fifteen and seven points, respectively. Compare that result to the effect of powerful antihypertensive drugs, such as calcium-channel blockers (for example, Norvasc, Cardizem, Procardia), which have been found to reduce blood pressure by only eight and three points, respectively, or to ACE inhibitors (such as Vasotec, Lotensin, Zestril, Altace), which drop patients’ blood pressure by only five and two points, respectively.126 Ground flaxseeds may work two to three times better than these medicines, and they have only good side effects. In addition to their anticancer properties, flaxseeds have been demonstrated in clinical studies to help control cholesterol, triglyceride, and blood sugar levels; reduce inflammation, and successfully treat constipation.127 Hibiscus Tea for Hypertension Hibiscus tea, derived from the flower of the same name, is also known as roselle, sorrel, jamaica, or sour tea. With
Michael Greger (How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease)
Tris,” he says. “What did they do to you? You’re acting like a lunatic.” “That’s not very nice of you to say,” I say. “They put me in a good mood, that’s all. And now I really want to kiss you, so if you could just relax--” “I’m not going to kiss you. I’m going to figure out what’s going on,” he says. I pout my lower lip for a second, but then I grin as the pieces come together in my mind. “That’s why you like me!” I exclaim. “Because you’re not very nice either! It makes so much more sense now.” “Come on,” he says. “We’re going to see Johanna.” “I like you, too.” “That’s encouraging,” he replies flatly. “Come on. Oh, for God’s sake. I’ll just carry you.” He swings me into his arms, one arm under my knees and the other around my back. I wrap my arms around his neck and plant a kiss on his cheek. Then I discover that the air feels nice on my feet when I kick them, so I move my feet up and down as he walks us toward the building where Johanna works. When we reach her office, she is sitting behind a desk with a stack of paper in front of her, chewing on a pencil eraser. She looks up at us, and her mouth drifts open slightly. A hunk of dark hair covers the left side of her face. “You really shouldn’t cover up your scar,” I say. “You look prettier with your hair out of your face.” Tobias sets me down too heavily. The impact is jarring and hurts my shoulder a little, but I like the sound my feet made when they hit the floor. I laugh, but neither Johanna nor Tobias laughs with me. Strange. “What did you do to her?” Tobias says, terse. “What in God’s name did you do?” “I…” Johanna frowns at me. “They must have given her too much. She’s very small; they probably didn’t take her height and weight into account.” “They must have given her too much of what?” he says. “You have a nice voice,” I say. “Tris,” he says, “please be quiet.” “The peace serum,” Johanna says. “In small doses, it has a mild, calming effect and improves the mood. The only side effect is some slight dizziness. We administer it to members of our community who have trouble keeping the peace.” Tobias snorts. “I’m not an idiot. Every member of your community has trouble keeping the peace, because they’re all human. You probably dump it into the water supply.” Johanna does not respond for a few seconds. She folds her hands in front of her. “Clearly you know that is not the case, or this conflict would not have occurred,” she says. “But whatever we agree to do here, we do together, as a faction. If I could give the serum to everyone in this city, I would. You would certainly not be in the situation you are in now if I had.” “Oh, definitely,” he says. “Drugging the entire population is the best solution to our problem. Great plan.” “Sarcasm is not kind, Four,” she says gently. “Now, I am sorry about the mistake in giving too much to Tris, I really am. But she violated the terms of our agreement, and I’m afraid that you might not be able to stay here much longer as a result. The conflict between her and the boy--Peter--is not something we can forget.” “Don’t worry,” says Tobias. “We intend to leave as soon as humanly possible.
Veronica Roth (Insurgent (Divergent, #2))
Flow is an extremely potent response to external events and requires an extraordinary set of signals. The process includes dopamine, which does more than tune signal-to-noise ratios. Emotionally, we feel dopamine as engagement, excitement, creativity, and a desire to investigate and make meaning out of the world. Evolutionarily, it serves a similar function. Human beings are hardwired for exploration, hardwired to push the envelope: dopamine is largely responsible for that wiring. This neurochemical is released whenever we take a risk or encounter something novel. It rewards exploratory behavior. It also helps us survive that behavior. By increasing attention, information flow, and pattern recognition in the brain, and heart rate, blood pressure, and muscle firing timing in the body, dopamine serves as a formidable skill-booster as well. Norepinephrine provides another boost. In the body, it speeds up heart rate, muscle tension, and respiration, and triggers glucose release so we have more energy. In the brain, norepinephrine increases arousal, attention, neural efficiency, and emotional control. In flow, it keeps us locked on target, holding distractions at bay. And as a pleasure-inducer, if dopamine’s drug analog is cocaine, norepinephrine’s is speed, which means this enhancement comes with a hell of a high. Endorphins, our third flow conspirator, also come with a hell of a high. These natural “endogenous” (meaning naturally internal to the body) opiates relieve pain and produce pleasure much like “exogenous” (externally added to the body) opiates like heroin. Potent too. The most commonly produced endorphin is 100 times more powerful than medical morphine. The next neurotransmitter is anandamide, which takes its name from the Sanskrit word for “bliss”—and for good reason. Anandamide is an endogenous cannabinoid, and similarly feels like the psychoactive effect found in marijuana. Known to show up in exercise-induced flow states (and suspected in other kinds), this chemical elevates mood, relieves pain, dilates blood vessels and bronchial tubes (aiding respiration), and amplifies lateral thinking (our ability to link disparate ideas together). More critically, anandamide also inhibits our ability to feel fear, even, possibly, according to research done at Duke, facilitates the extinction of long-term fear memories. Lastly, at the tail end of a flow state, it also appears (more research needs to be done) that the brain releases serotonin, the neurochemical now associated with SSRIs like Prozac. “It’s a molecule involved in helping people cope with adversity,” Oxford University’s Philip Cowen told the New York Times, “to not lose it, to keep going and try to sort everything out.” In flow, serotonin is partly responsible for the afterglow effect, and thus the cause of some confusion. “A lot of people associate serotonin directly with flow,” says high performance psychologist Michael Gervais, “but that’s backward. By the time the serotonin has arrived the state has already happened. It’s a signal things are coming to an end, not just beginning.” These five chemicals are flow’s mighty cocktail. Alone, each packs a punch, together a wallop.
Steven Kotler (The Rise of Superman: Decoding the Science of Ultimate Human Performance)
From another corner of neuroscience, we’re learning about a neurotransmitter called dopamine. Though there are more than fifty neurotransmitters (that we know of), scientists studying substance problems have given dopamine much of their attention. The brain’s reward system and pleasure centers—the areas most impacted by substance use and compulsive behaviors—have a high concentration of dopamine. Some brains have more of it than others, and some people have a capacity to enjoy a range of experiences more than others, owing to a combination of genetics and environment. The thing about dopamine is that it makes us feel really good. We tend to want more of it. It is naturally generated through ordinary, pleasurable activities like eating and sex, and it is the brain’s way of rewarding us—or nature’s way of rewarding the brain—for activities necessary to our survival, individually or as a species. It is the “mechanism by which ‘instinct’ is manifest.” Our brains arrange for dopamine levels to rise in anticipation and spike during a pleasurable activity to make sure we do it again. It helps focus our attention on all the cues that contributed to our exposure to whatever felt good (these eventually become triggers to use, as we explain later). Drugs and alcohol (and certain behaviors) turn on a gushing fire hose of dopamine in the brain, and we feel good, even euphoric. Dopamine produced by these artificial means, however, throws our pleasure and reward systems out of whack immediately. Flooding the brain repeatedly with dopamine has long-term effects and creates what’s known as tolerance—when we lose our ability to produce or absorb our own dopamine and need more and more of it artificially just to feel okay. Specifically, the brain compensates for the flood of dopamine by decreasing its own production of it or by desensitizing itself to the neurotransmitter by reducing the number of dopamine receptors, or both. The brain is just trying to keep a balance. The problem with the brain’s reduction in natural dopamine production is that when you take the substance or behavior out of the picture, there’s not enough dopamine in the brain to make you feel good. Without enough dopamine, there is no interest or pleasure. Then not only does the brain lose the pleasure associated with using, it might not be able to enjoy a sunset or a back rub, either. A lowered level of dopamine, combined with people’s longing for the rush of dopamine they got from using substances, contributes to “craving” states. Cravings are a physiological process associated with the brain’s struggle to regain its normal dopamine balance, and they can influence a decision to keep using a substance even when a person is experiencing negative consequences that matter to him and a strong desire to change. Depending on the length of time and quantities a person has been using, these craving states can be quite uncomfortable and compelling. The dopamine system can and does recover, starting as soon as we stop flooding it. But it takes time, and in the time between shutting off the artificial supply of dopamine and the brain’s rebuilding its natural resources, people tend to feel worse (before they feel better). On a deep, instinctual level, their brains are telling them that by stopping using, something is missing; something is wrong. This is a huge factor in relapse, despite good intentions and effort to change. Knowing this can help you and your loved one make it across this gap in brain reward systems.
Jeffrey Foote (Beyond Addiction: How Science and Kindness Help People Change)