Dna Related Quotes

Somewhere in our DNA must lie the key mutation (or, more probably, mutations) that set us apart—the mutations that make us the sort of creature that could wipe out its nearest relative, then dig up its bones and reassemble its genome.

Why bother taking a DNA Test to discover your genealogy? Just go buy a lottery ticket, and if you win, all your distant relatives will find you.

Genetics, not lack of willpower, is the major reason why people differ in BMI. Success and failure, credit and blame, in overcoming problems should be calibrated relative to genetic strengths and weaknesses.

Judging Natalie as my mother had judged me was, I felt like telling her son, just my ass-backward way of showing love. I'd spent my life trying to translate that language, and now I realized I had come to speak it fluently. When was it that you realized the thread woven through your DNA carried the relationship deformities of your blood relatives as much as it did their diabetes and bone density?

What's the point of sharing 100 percent of your DNA with a person if you can't wake them up for an emergency chat.

If one stretches out the DNA contained in the nucleus of a human cell, one obtains a two-yard-long thread that is only ten atoms wide. This thread is a billion times longer than its own width. Relatively speaking, it is as if your little finger stretched from Paris to Los Angeles.

We seem to be tiny specks in the vast ocean of our DNA pool when it is all mapped out, and it is that – the literal relativity of it all – which takes their breath away.

We are connected to other human beings on this earth– genetically, historically,' Winn says. 'It's like magnets, I may not know where the other end of the magnet is, but I'm being pulled to it. How can we answer anything about ourselves if we don't know what our roots are, if we don't know who are people are?

The thing with true family, from everything he’d learned? Sometimes they shared DNA with you. Sometimes they didn’t. And given that the blood connection only went so far, the friends you chose were what made up the slack when your relatives sucked.

Not knowing the DNA we carry in our bodies, hearts, and minds. does not negate it. We are an accumulation of many people, even more so when unaware of it. Once aware, we can choose what to carry and what to relegate to history.

We are born with a seed of selfhood that contains the spiritual DNA of our uniqueness-an encoded birthright knowledge of who we are, why we are here, and how we are related to others. We may abandon that knowledge as the years go by, but it never abandons us.

A great surprise that emerges from the genome revolution is that in the relatively recent past, human populations were just as different from each other as they are today, but that the fault lines across populations were almost unrecognizably different from today.

Aren’t all demigods related on the godly side, and doesn’t that make dating gross? But the thing is, the godly side of your family doesn’t count, genetically speaking, since gods don’t have DNA. A demigod would never think about dating someone who had the same godly parent. Like two kids from Athena cabin? No way. But a daughter of Aphrodite and a son of Hephaestus? They’re not related. So it’s no problem.

All life on our planet is related, and the readout of letters in DNA shows exactly how. By comparing DNA sequences, we can compute statistically how closely related we are to anything, from monkeys to marsupials, to reptiles, amphibians, fish, insects, crustaceans, worms, plants, protozoa, bacteria–you name it.

I ask the ladies what we lose with each generation. They seem to agree: usually language goes first, then memories of relatives and grandparents, then traditions, then longing for home, then a sense of identity. What do we have left? A wedding ritual, a few old photos? For me, what is left is our connection to food. Our food traditions are the last thing we hold on to. They are not just recipes; they are a connection to the nameless ancestors who gave us our DNA. That's why our traditional foods are so important. The stories, the memories, the movements that have been performed for generations - without them, we lose our direction.

DNA testing poses questions that people in the adoptee community have thought about far longer than such testing has been around. Will my birth mother/father/half-sister be happy to know me? And more broadly, what is that person to me? What do we mean when we speak of 'family'? How much does genetics get to tell us about who we are?

the single most important source of ancestry across northern Europe today is the Yamnaya or groups closely related to them.

But since anagram-related clues are now inadmissible as evidence, we sent the pork pie off for DNA analysis and managed to pinpoint the pie shop where it was purchased.

We went to bed at a normal time, and then I woke up in the middle of the night to the sound of him fucking some guy!" "Are you sure you're related? Can we get a DNA test?

... a recent study showed they were our closest relatives, sharing 98.7% of our DNA.

Time is the enemy of secret-keepers, because with time comes the inevitable revelation, one way or another.

The ancient DNA revolution documented that the first farmers even in the most remote reaches of Europe—Britain, Scandinavia, and Iberia—had very little hunter-gatherer-related ancestry.

No sane paleontologist would ever claim that he or she had discovered "The Ancestor." Think about it this way: What is the chance that while walking through any random cemetery on our planet I would discover an actual ancestor of mine? Diminishingly small. What I would discover is that all people buried in these cemeteries-- no mater whether that cemetery is in China, Botswana, or Italy-- are related to me to different degrees. I can find this out by looking at their DNA with many of the forensic techniques in use in crime labs today. I'd see that some of the denizens of the cemeteries are distantly related to me, others are related more closely. This tree would be a very powerful window into my past and my family history. It would also have a practical application because I could use this tree to understand my predilection to get certain diseases and other facts of my biology. The same is true when we infer relationship among species.

With this approach, we found that at least some Neanderthal-related genetic material came into the ancestors of present-day non-Africans eighty-six thousand to thirty-seven thousand years ago.20

Consider the genesis of a single-celled embryo produced by the fertilization of an egg by a sperm. The genetic material of this embryo comes from two sources: paternal genes (from sperm) and maternal genes (from eggs). But the cellular material of the embryo comes exclusively from the egg; the sperm is no more than a glorified delivery vehicle for male DNA—a genome equipped with a hyperactive tail. Aside from proteins, ribosomes, nutrients, and membranes, the egg also supplies the embryo with specialized structures called mitochondria. These mitochondria are the energy-producing factories of the cell; they are so anatomically discrete and so specialized in their function that cell biologists call them “organelles”—i.e., mini-organs resident within cells. Mitochondria, recall, carry a small, independent genome that resides within the mitochondrion itself—not in the cell’s nucleus, where the twenty-three pairs of chromosomes (and the 21,000-odd human genes) can be found. The exclusively female origin of all the mitochondria in an embryo has an important consequence. All humans—male or female—must have inherited their mitochondria from their mothers, who inherited their mitochondria from their mothers, and so forth, in an unbroken line of female ancestry stretching indefinitely into the past. (A woman also carries the mitochondrial genomes of all her future descendants in her cells; ironically, if there is such a thing as a “homunculus,” then it is exclusively female in origin—technically, a “femunculus”?) Now imagine an ancient tribe of two hundred women, each of whom bears one child. If the child happens to be a daughter, the woman dutifully passes her mitochondria to the next generation, and, through her daughter’s daughter, to a third generation. But if she has only a son and no daughter, the woman’s mitochondrial lineage wanders into a genetic blind alley and becomes extinct (since sperm do not pass their mitochondria to the embryo, sons cannot pass their mitochondrial genomes to their children). Over the course of the tribe’s evolution, tens of thousands of such mitochondrial lineages will land on lineal dead ends by chance, and be snuffed out. And here is the crux: if the founding population of a species is small enough, and if enough time has passed, the number of surviving maternal lineages will keep shrinking, and shrinking further, until only a few are left. If half of the two hundred women in our tribe have sons, and only sons, then one hundred mitochondrial lineages will dash against the glass pane of male-only heredity and vanish in the next generation. Another half will dead-end into male children in the second generation, and so forth. By the end of several generations, all the descendants of the tribe, male or female, might track their mitochondrial ancestry to just a few women. For modern humans, that number has reached one: each of us can trace our mitochondrial lineage to a single human female who existed in Africa about two hundred thousand years ago. She is the common mother of our species. We do not know what she looked like, although her closest modern-day relatives are women of the San tribe from Botswana or Namibia. I find the idea of such a founding mother endlessly mesmerizing. In human genetics, she is known by a beautiful name—Mitochondrial Eve.

There has been relatively little change in human DNA in the last 10,000 years. But it is likely that we will be able to redesign it completely in the next thousand. Of course, many people will say that genetic engineering on humans should be banned. But I rather doubt that they will be able to prevent it. Genetic engineering on plants and animals will be allowed for economic reasons, and someone is bound to try it on humans.

The Yamnaya—who the genetic data show were closely related to the source of the steppe ancestry in both India and Europe—are obvious candidates for spreading Indo-European languages to both these subcontinents of Eurasia.

Some of the stigmas seem so dated that you'd think these secrets couldn't hurt anymore, but they do. Because, in fact, out of those secrets came people– people who can sometimes still sense the shame that surrounded their hidden identities.

Apart from a few viruses, all life on Earth now relies on DNA to hold the information that it needs to reproduce. But the most likely players in the first games of life were molecules of the related genetic material RNA, which is more flexible than DNA because it can both carry information down the generations and also catalyze—speed up—chemical reactions, a very handy feat. And RNA still carries out all kinds of critical roles in organisms that are described by DNA, including human beings.

There is a continuum of genetic influence from one extreme to the other. In other words, as we find genes associated with reading disability, these DNA differences will not be ‘for’ reading disability. They will be related to the entire distribution of reading ability. These DNA differences will make good readers read slightly less well than other good readers without these genetic variants. Conversely, as we find genes associated with reading ability, the same genes will predict reading problems.

All dogs are predators, but over thousands of generations, we’ve created sporting breeds to be exceptionally focused predators. All dogs like to dig and chase small prey, but terriers are superdriven to dig and find rodents. All dogs love to run, but greyhounds can run up to forty miles an hour, and huskies can run for hours and hours on end. All dogs have the natural ability to fight or wrestle with one another, but the bully breeds have been genetically engineered to fight to the death. The more pure the bloodline, the more that genetic “boost” will probably play a part in your dog’s behavior. That’s why some owners claim that their “mutts” make mellower pets, because, they theorize, their DNA has been somewhat diluted, and their breed-related drives diffused as a result.

strongest animals in the world thrive on a fruit-and plant-based diet. Silverback gorillas, for example, are thirty times as strong as man and three times our size. Their DNA is 99 percent similar to that of humans, and they are our closest living relatives next to chimps. How are they so strong? Oh

How do fields express their principles? Physicists use terms like photons, electrons, quarks, quantum wave functions, relativity, and energy conservation. Astronomers use terms like planets, stars, galaxies, Hubble shift, and black holes. Thermodynamicists use terms like entropy, first law, second law, and Carnot cycle. Biologists use terms like phylogeny, ontology, DNA, and enzymes. Each of these terms can be considered to be the thread of a story. The principles of a field are actually a set of interwoven stories about the structure and behavior of field elements, the fabric of the multiverse.

After analyzing the DNA of 13,000 Australians, scientists recently found several genes that differed between liberals and conservatives.15 Most of them related to neurotransmitter functioning, particularly glutamate and serotonin, both of which are involved in the brain’s response to threat and fear.

Oxytocin and vasopressin are chemically similar hormones; the DNA sequences that constitute their genes are similar, and the two genes occur close to each other on the same chromosome. There was a single ancestral gene that, a few hundred million years ago, was accidentally “duplicated” in the genome, and the DNA sequences in the two copies of the gene drifted independently, evolving into two closely related genes

I think she’ll like me,” I said, concerned that my own mother wouldn’t like me. My fear exposed the unspoken shame of all families: if you didn’t know the people you were related to, would you befriend them? In the days when families hunted and gathered, this wouldn’t be a question worth pondering, but once butchering a mammoth stopped being a household chore, we began to suspect families are chain gangs held together by manacles of DNA.

After reading the Passover story, Jews intuitively understand how within their population, numbering millions of people, they are related to each other and the past. The story allows Jews to think of those millions of coreligionists as direct relations—and to treat them with equal respect and seriousness even if they do not understand their exact relationships—to break out from the trap of thinking of the world from the perspective of the relatively small families we were raised in. For me, the multitude

The other side of this coin is that viruses may be genes who have broken loose from ‘colonies’ such as ourselves. Viruses consist of pure DNA (or a related self-replicating molecule) surrounded by a protein jacket. They are all parasitic. The suggestion is that they have evolved from ‘rebel’ genes who escaped, and now travel from body to body directly through the air, rather than via the more conventional vehicles—sperms and eggs. If this is true, we might just as well regard ourselves as colonies of viruses!

The Pyrenean ibex, an extinct form of wild mountain goat, was brought back to life in 2009 through cloning of dna taken from skin samples. This was followed in June of 2010 by researchers at Jeju National University in Korea cloning a bull that had been dead for two years. Cloning methods are also being studied for use in bringing back Tasmanian tigers, woolly mammoths, and other extinct creatures, and in the March/April 2010 edition of the respected Archaeology magazine, a feature article by Zah Zorich (“Should We Clone Neanderthals?”) called for the resurrection via cloning of what some consider to be man’s closest extinct relative, the Neanderthals. National Geographic confirmed this possibility in its May 2009 special report, “Recipe for a Resurrection,” quoting Hendrik Poinar of McMaster University, an authority on ancient dna who served as a scientific consultant for the movie Jurassic Park, saying: “I laughed when Steven Spielberg said that cloning extinct animals was inevitable. But I’m not laughing anymore.… This is going to happen.

At the time of this writing, our knowledge of East Asian population history is relatively limited compared to that of West Eurasia because less than 5 percent of published ancient DNA data comes from East Asia. The difference reflects the fact that ancient DNA technology was invented in Europe, and it is nearly impossible for researchers to export samples from China and Japan because of government restrictions or a preference that studies be led by local scientists. This has meant that these regions have missed out on the first few years of the ancient DNA revolution.

In the late twentieth century democracies usually outperformed dictatorships because democracies were better at data-processing. Democracy diffuses the power to process information and make decisions among many people and institutions, whereas dictatorship concentrates information and power in one place. Given twentieth-century technology, it was inefficient to concentrate too much information and power in one place. Nobody had the ability to process all the information fast enough and make the right decisions. This is part of the reason why the Soviet Union made far worse decisions than the United States, and why the Soviet economy lagged far behind the American economy. “However, soon AI might swing the pendulum in the opposite direction. AI makes it possible to process enormous amounts of information centrally. Indeed, AI might make centralised systems far more efficient than diffused systems, because machine learning works better the more information it can analyse. If you concentrate all the information relating to a billion people in one database, disregarding all privacy concerns, you can train much better algorithms than if you respect individual privacy and have in your database only partial information on a million people. For example, if an authoritarian government orders all its citizens to have their DNA scanned and to share all their medical data with some central authority, it would gain an immense advantage in genetics and medical research over societies in which medical data is strictly private. The main handicap of authoritarian regimes in the twentieth century – the attempt to concentrate all information in one place – might become their decisive advantage in the twenty-first century.

One article on reproductive strategies was titled "Sneaky Fuckers." Kya laughed. As is well known, the article began, in nature, usually the males with the most prominent secondary sexual characteristics, such as the biggest antlers, deepest voices, broadest chests, and superior knowledge secure the best territories because they have fended off weaker males. The females choose to mate with these imposing alphas and are thereby inseminated with the best DNA around, which is passed on to the female's offspring- one of the most powerful phenomena in the adaptation and continuance of life. Plus, the females get the best territory for their young. However, some stunted males, not strong, adorned, or smart enough to hold good territories, possess bags of tricks to fool the females. They parade their smaller forms around in pumped-up postures or shout frequently- even if in shrill voices. By relying on pretense and false signals, they manage to grab a copulation here or there. Pint-sized male bullfrogs, the author wrote, hunker down in the grass and hide near an alpha male who is croaking with great gusto to call in mates. When several females are attracted to his strong vocals at the same time, and the alpha is busy copulating with one, the weaker male leaps in and mates one of the others. The imposter males were referred to as "sneaky fuckers." Kya remembered, those many years ago, Ma warning her older sisters about young men who overrevved their rusted-out pickups or drove jalopies around with radios blaring. "Unworthy boys make a lot of noise," Ma had said. She read a consolation for females. Nature is audacious enough to ensure that the males who send out dishonest signals or go from one female to the next almost always end up alone. Another article delved into the wild rivalries between sperm. Across most life-forms, males compete to inseminate females. Male lions occasionally fight to the death; rival bull elephants lock tusks and demolish the ground beneath their feet as they tear at each other's flesh. Though very ritualized, the conflicts can still end in mutilations. To avoid such injuries, inseminators of some species compete in less violent, more creative methods. Insects, the most imaginative. The penis of the male damselfly is equipped with a small scoop, which removes sperm ejected by a previous opponent before he supplies his own. Kya dropped the journal on her lap, her mind drifting with the clouds. Some female insects eat their mates, overstressed mammal mothers abandon their young, many males design risky or shifty ways to outsperm their competitors. Nothing seemed too indecorous as long as the tick and the tock of life carried on. She knew this was not a dark side to Nature, just inventive ways to endure against all odds. Surely for humans there was more.

There is also a second great area of unrealized common cause between Native Americans and geneticists—the potential to use ancient DNA to measure the sizes of populations that existed prior to 1492 by looking at variation within the genome of ancient samples. This is a critical issue for Native Americans, as there is evidence for about a tenfold collapse in population size in the Americas following the arrival of Europeans and the waves of epidemic disease that Europeans brought, leading to the dissolution of previously established complex societies. The relatively small population sizes that European colonialists encountered when they arrived in the Americas were used to provide moral justification for the annexation of Native American lands.

It is in the area of shedding light on human migrations—rather than in explaining human biology—that the genome revolution has already been a runaway success. In the last few years, the genome revolution—turbocharged by ancient DNA—has revealed that human populations are related to each other in ways that no one expected. The story that is emerging differs from the one we learned as children, or from popular culture. It is full of surprises: massive mixtures of differentiated populations; sweeping population replacements and expansions; and population divisions in prehistoric times that did not fall along the same lines as population differences that exist today. It is a story about how our interconnected human family was formed, in myriad ways never imagined.

Scientists know your DNA reflects the genetic legacy of your parents, their parents, and your ancestors. It’s possible that it also reflects their emotional experiences. As researchers learn more about our DNA, maybe we’ll find that our cells have encoded the traumas of our ancestors. Experiments in mice have shown that aversion to certain smells is passed down to the offspring after the parental mice were trained to avoid a certain smell by being shocked every time they smelled it.8 While we know that a family history of heart disease may mean close relatives share genes and genetic markers, if we look back, we can often see in family stories hearts that are broken, conflicted, and prevented from loving fully. In my family, people tend to die of heart disease prematurely. My maternal

In the late twentieth century democracies usually outperformed dictatorships because democracies were better at data-processing. Democracy diffuses the power to process information and make decisions among many people and institutions, whereas dictatorship concentrates information and power in one place. Given twentieth-century technology, it was inefficient to concentrate too much information and power in one place. Nobody had the ability to process all the information fast enough and make the right decisions. This is part of the reason why the Soviet Union made far worse decisions than the United States, and why the Soviet economy lagged far behind the American economy. However, soon AI might swing the pendulum in the opposite direction. AI makes it possible to process enormous amounts of information centrally. Indeed, AI might make centralised systems far more efficient than diffused systems, because machine learning works better the more information it can analyse. If you concentrate all the information relating to a billion people in one database, disregarding all privacy concerns, you can train much better algorithms than if you respect individual privacy and have in your database only partial information on a million people. For example, if an authoritarian government orders all its citizens to have their DNA scanned and to share all their medical data with some central authority, it would gain an immense advantage in genetics and medical research over societies in which medical data is strictly private. The main handicap of authoritarian regimes in the twentieth century – the attempt to concentrate all information in one place – might become their decisive advantage in the twenty-first century.

Hey, that's weird," Chloe says. "You both have the same color eyes as Emma. I've never seen that before. I always thought it was because she's freakishly pasty. Ow! That's gonna leave a mark, Emma," she says, rubbing her freshly pinched biceps. "Good, I hope it does," I snap. I want to ask them about their eyes-the color seems prettier set against the olive tone of Galen's skin-but Chloe has bludgeoned my chances of recovering from embarrassment. I'll have to be satisfied that my dad-and Google-were wrong all this time; my eye color just can't be that rare. Sure, my dad practiced medicine until the day he died two years ago. And sure, Google never let me down before. But who am I to argue with living, breathing proof that this eye color actually does exist? Nobody, that's who. Which is convenient, since I don't want to talk anymore. Don't want to force Galen into any more awkward conversations. Don't want to give Chloe any more opportunities to deepen the heat of my burning cheeks. I just want this moment of my life to be over. I push past Chloe and snatch up the surfboard. To her good credit, she presses herself against the rail as I pass her again. I stop in front of Galen and his sister. "It was nice to meet you both. Sorry I ran into you. Let's go, Chloe." Galen looks like he wants to say something, but I turn away. He's been a good sport, but I'm not interested in discussing swimmer safety-or being introduced to any more of his hostile relatives. Nothing he can say will change the fact that DNA from my cheek is smeared on his chest. Trying not to actually march, I thrust past them and make my way down the stairs leading to the pristine white sand. I hear Chloe closing the distance behind me, giggling. And I decide on sunflowers for her funeral.

How does the body push the comparatively tiny genome so far? Many researchers want to put the weight on learning and experience, apparently believing that the contribution of the genes is relatively unimportant. But though the ability to learn is clearly one of the genome's most important products, such views overemphasize learning and significantly underestimate the extent to which the genome can in fact guide the construction of enormous complexity. If the tools of biological self-assembly are powerful enough to build the intricacies of the circulatory system or the eye without requiring lessons from the outside world, they are also powerful enough to build the initial complexity of the nervous system without relying on external lessons. The discrepancy melts away as we appreciate the true power of the genome. We could start by considering the fact that the currently accepted figure of 30,000 could well prove to be too low. Thirty thousand (or thereabouts) is, at press time, the best estimate for how many protein-coding genes are in the human genome. But not all genes code for proteins; some, not counted in the 30,000 estimate, code for small pieces of RNA that are not converted into proteins (called microRNA), of "pseudogenes," stretches of DNA, apparently relics of evolution, that do not properly encode proteins. Neither entity is fully understood, but recent reports (from 2002 and 2003) suggest that both may play some role in the all-important process of regulating the IFS that control whether or not genes are expressed. Since the "gene-finding" programs that search the human genome sequence for genes are not attuned to such things-we don't yet know how to identify them reliably-it is quite possible that the genome contains more buried treasure.

History favors the bold. Compensation favors the meek. As a Fortune 500 company CEO, you’re better off taking the path often traveled and staying the course. Big companies may have more assets to innovate with, but they rarely take big risks or innovate at the cost of cannibalizing a current business. Neither would they chance alienating suppliers or investors. They play not to lose, and shareholders reward them for it—until those shareholders walk and buy Amazon stock. Most boards ask management: “How can we build the greatest advantage for the least amount of capital/investment?” Amazon reverses the question: “What can we do that gives us an advantage that’s hugely expensive, and that no one else can afford?” Why? Because Amazon has access to capital with lower return expectations than peers. Reducing shipping times from two days to one day? That will require billions. Amazon will have to build smart warehouses near cities, where real estate and labor are expensive. By any conventional measure, it would be a huge investment for a marginal return. But for Amazon, it’s all kinds of perfect. Why? Because Macy’s, Sears, and Walmart can’t afford to spend billions getting the delivery times of their relatively small online businesses down from two days to one. Consumers love it, and competitors stand flaccid on the sidelines. In 2015, Amazon spent $7 billion on shipping fees, a net shipping loss of $5 billion, and overall profits of $2.4 billion. Crazy, no? No. Amazon is going underwater with the world’s largest oxygen tank, forcing other retailers to follow it, match its prices, and deal with changed customer delivery expectations. The difference is other retailers have just the air in their lungs and are drowning. Amazon will surface and have the ocean of retail largely to itself.

I shuffled uneasily and pretended to go through some more reports. Technically, even on inspection, it was against camp rules for two campers of the opposite sex to be ... like, alone in a cabin. That rule had come up a lot when Silena and Beckendorf started dating. And I know some of you might be thinking: aren't all demigods related on the godly side, and doesn't that make dating gross? But the thing is, the godly side of your family doesn't count genetically speaking since gods don't have DNA. A demigod would never think about dating someone who had the same godly parent. Like two kids from Athena cabin? No way. But a daughter of Aphrodite and a son of Hephaestus? They're not related, so it's no problem. Anyway, for some strange reason I was thinking about this as I watched Annabeth straighten up. She'd closed her laptop which she'd gotten given a gift from the inventor Daedalus last summer.

In the last year, ancestral DNA had become popular with people curious about their genealogy and, though this was much less publicized, as a tool for finding unidentified criminals. Many in law enforcement were wary. There were quality-assurance issues. Privacy issues. Holes knew DNA. Knew it well. In his opinion, ancestral DNA was a tool, not a certainty. He had a Y-DNA profile generated from the EAR’s DNA, which means he isolated the EAR’s paternal lineage. The Y-DNA profile could be input into certain genealogical websites, the kind that people use to find first cousins and the like. You input a set of markers from your Y-DNA profile, anywhere from 12 to 111, and a list of matches is returned, surnames of families with whom you might share a common ancestor. Almost always the matches are at a genetic distance of 1 from you, which doesn’t mean much, relative-seeking-wise. You’re looking for the elusive 0—a close match.

Viruses, for instance, perform a really irritating function of intermingling the DNA from every species on Earth with every other. As Richard Lewontin puts it . . . It used to be thought that new functions had to arise by mutations of the genes already possessed by a species and that the only way such mutations could spread was by the normal processes of reproduction. It is now clear that genetic material has moved during evolution from species to species by means of retroviruses and other transposable particles. . . . What is so extraordinary in its implications for evolution is that transposition can occur between forms of life that are quite different, between distantly related vertebrates, for example, or even between plants and bacteria. . . . Thus, the assumption that species are on independent evolutionary pathways, once they have diverged from each other and can no longer interbreed, is incorrect. All life-forms are in potential genetic contact and genetic exchanges between them are going on. . . . The evolutionary “tree of life” seems the wrong metaphor. Perhaps we should think of it as an elaborate bit of macramé.16

while the behaviour patterns of archaic humans remained fixed for tens of thousands of years, Sapiens could transform their social structures, the nature of their interpersonal relations, their economic activities and a host of other behaviours within a decade or two. Consider a resident o Berlin, born in 1900 and living to the ripe age of one hundred. She spent her childhood in the Hohenzollern Empire of Wilhelm II; her adult years in the Weimar Republic, the Nazi Third Reich and Communist East Germany; and she died a citizen of a democratic and reunified Germany. She had managed to be a part of five very different sociopolitical systems, though her DNA remained exactly the same. This was the key to Sapiens' success. In a one-on-one brawl, a Neanderthal would probably have beaten a Sapiens. But in a conflict of hundreds, Neanderthals wouldn't stand a chance. Neanderthals could share information about the whereabouts of lions, but they probably could not tell - and revise - stories about tribal spirits. Without an ability to compose fiction, Neanderthals were unable to cooperate effectively in large numbers, nor could they adapt their social behaviour to rapidly changing challenging. (p. 38)

when we consider DNA, the genotype is the DNA sequence that contains instructions for the living organism. The phenotype is the observable characteristics of an organism, such as its anatomy, biochemistry, physiology, and behavior. The genotype interacts with the environment to produce the phenotype. To put this in an everyday situation, consider the blueprint as a house’s genotype and the actual house its phenotype. The phenotypic construction process is the building of the house using the blueprint as information about what and how to do it. The phenotype is related to the genotype that describes it, but there is a world of physical difference between the genotype and the phenotype and even the phenotypic construction process. For one, the genotype is non-dynamic; it is a quiescent, one-dimensional sequence of symbols (DNA’s symbols are nucleotides) that has no energy or time constraints. Like a blueprint, it can sit around for years, as you have probably learned from watching CSI. The genotype dictates what should be constructed (perhaps a really cute dog), but the DNA itself does not look or act anything like a cute dog. On the other hand, the phenotype (the cute dog) is dynamic and uses energy, especially if it is a border collie.

The period before fifty thousand years ago was a busy time in Eurasia, with multiple human populations arriving from Africa beginning at least 1.8 million years ago. These populations split into sister groups, diverged, and mixed again with each other and with new arrivals. Most of those groups have since gone extinct, at least in their “pure” forms. We have known for a while, from skeletons and archaeology, that there was some impressive human diversity prior to the migration of modern humans out of Africa. However, we did not know before ancient DNA was extracted and studied that Eurasia was a locus of human evolution that rivaled Africa. Against this background, the fierce debates about whether modern humans and Neanderthals interbred when they met in western Eurasia—which have been definitively resolved in favor of interbreeding events that made a contribution to billions of people living today—seem merely anticipatory. Europe is a peninsula, a modest-sized tip of Eurasia. Given the wide diversity of Denisovans and Neanderthals—already represented in DNA sequences from at least three populations separated from each other by hundreds of thousands of years, namely Siberian Denisovans, Australo-Denisovans, and Neanderthals—the right way to view these populations is as members of a loosely related family of highly evolved archaic humans who inhabited a vast region of Eurasia.

It's funny, you know. We're free. We make choices. We weigh things in our minds, consider everything carefully, use all the tools of logic and education. And in the end, what we mostly do is what we have no choice but to do. Makes you think, why bother? But you bother because you do, that's why. Because you're a DNA-brand computer running Childhood 1.0 software. They update the software but the changes are always just around the edges. You have the brain you have, the intelligence, the talents, the strengths and weaknesses you have, from the moment they take you out of the box and throw away the Styrofoam padding. But you have the fears you picked up along the way. The terrors of age four or six or eight are never suspended, just layered over. The dread I'd felt so recently, a dread that should be so much greater because the facts had been so much more horrible, still could not diminish the impact of memories that had been laid down long years before. It's that way all through life, I guess. I have a relative who says she still gets depressed every September because in the back of her mind it's time for school to start again. She's my great-aunt. The woman is sixty-seven and still bumming over the first day of school five-plus decades ago. It's sad in a way because the pleasures of life get old and dated fast. The teenage me doesn't get the jolt the six-year-old me got from a package of Pop Rocks. The me I've become doesn't rush at the memories of the day I skated down a parking ramp however many years ago. Pleasure fades, gets old, gets thrown out with last year's fad. Fear, guilt, all that stuff stays fresh. Maybe that's why people get so enraged when someone does something to a kid. Hurt a kid and he hurts forever. Maybe an adult can shake it off. Maybe. But with a kid, you hurt them and it turns them, shapes them, becomes part of the deep, underlying software of their lives. No delete. I don't know. I don't know much. I feel like I know less all the time. Rate I'm going, by the time I'm twenty-one I won't know a damned thing. But still I was me. Had no choice, I guess. I don't know, maybe that's bull and I was just feeling sorry for myself. But, bottom line, I dried my eyes, and I pushed my dirty, greasy hair back off my face, and I started off down the road again because whatever I was, whoever I was, however messed up I might be, I wasn't leaving April behind. Maybe it was all an act programmed into me from the get-go, or maybe it grew up out of some deep-buried fear, I mean maybe at some level I was really just as pathetic as Senna thought I was. Maybe I was a fake. Whatever. Didn't matter. I was going back to the damned dragon, and then I was getting April out, and everything and everyone else could go screw themselves. One good thing: For now at least, I was done being scared.

Whatever their function in dinosaurs, the origin of feathers is most definitely not related to flight. Like lungs and limbs in the water-to-land transition, the inventions used for flight preceded the origin of flight.

The DNA molecule is shaped like a twisted ladder, and the rungs of the ladder—the nucleotides—can hold vast amounts of information, the code of life. A gene is a short stretch of DNA, typically about a thousand letters long, that holds the recipe for a protein or a group of related proteins. The total assemblage of an organism’s genetic code—its full complement of DNA, comprising all its genes—is the organism’s genome.

macy's, sears and walmart can't afford to spend billions getting the delivery times of their relatively small online businesses down from two days to one.

Once superintelligent AI has settled another solar system or galaxy, bringing humans there is easy — if humans have succeeded in programming the AI with this goal. All the necessary information about humans can be transmitted at the speed of light, after which the AI can assemble quarks and electrons into the desired humans. This could be done either in a low-tech way by simply transmitting the 2 gigabytes of information needed to specify a person’s DNA and then incubating a baby to be raised by the AI, or the AI could assemble quarks and electrons into full-grown people who would have all the memories scanned from their originals back on Earth. This means that if there’s an intelligence explosion, the key question isn’t if intergalactic settlement is possible, but simply how fast it can proceed. Since all the ideas we've explored above come from humans, they should be viewed as merely lower limits on how fast life can expand; ambitious superintelligent life can probably do a lot better, and it will have a strong incentive to push the limits, since in the race against time and dark energy, every 1% increase in average settlement speed translates into 3% more galaxies colonized. For example, if it takes 20 years to travel 10 light-years to the next star system with a laser-sail system, and then another 10 years to settle it and build new lasers and seed probes there, the settled region will be a sphere growing in all directions at a third of the speed of light on average. In a beautiful and thorough analysis of cosmically expanding civilizations in 2014, the American physicist Jay Olson considered a high-tech alternative to the island-hopping approach, involving two separate types of probes: seed probes and expanders. The seed probes would slow down, land and seed their destination with life. The expanders, on the other hand, would never stop: they'd scoop up matter in flight, perhaps using some improved variant of the ramjet technology, and use this matter both as fuel and as raw material out of which they'd build expanders and copies of themselves. This self-reproducing fleet of expanders would keep gently accelerating to always maintain a constant speed (say half the speed of light) relative to nearby galaxies, and reproduce often enough that the fleet formed an expanding spherical shell with a constant number of expanders per shell area. Last but not least, there’s the sneaky Hail Mary approach to expanding even faster than any of the above methods will permit: using Hans Moravec’s “cosmic spam” scam from chapter 4. By broadcasting a message that tricks naive freshly evolved civilizations into building a superintelligent machine that hijacks them, a civilization can expand essentially at the speed of light, the speed at which their seductive siren song spreads through the cosmos. Since this may be the only way for advanced civilizations to reach most of the galaxies within their future light cone and they have little incentive not to try it, we should be highly suspicious of any transmissions from extraterrestrials! In Carl Sagan’s book Contact, we earthlings used blueprints from aliens to build a machine we didn’t understand — I don’t recommend doing this ... In summary, most scientists and sci-fi authors considering cosmic settlement have in my opinion been overly pessimistic in ignoring the possibility of superintelligence: by limiting attention to human travelers, they've overestimated the difficulty of intergalactic travel, and by limiting attention to technology invented by humans, they've overestimated the time needed to approach the physical limits of what's possible.

Could that test be the answer to some of my lifelong questions about who I was? Could I really get the answer about my ethnicity or where I came from? Would I find people I was related to?

Because there are people in our lives; rare unexpected people who don't just walk beside us through life; they witness our lives too. They hold our memories in their DNA. So that when one body forgets, the other is there to push rewind, to cue up the highlights reel on a love story that made it all worth it.

The resulting tree, or phylogram, to use the proper name, again recognised the four main branches (I–IV in the figure on page 17) of modern dog breeds initially published by Wayne and Vilà. The results were fascinating. The fossil dogs on three of the four branches (I, III, IV) of the tree are closely related to modern breeds while the rare fourth, mainly Scandinavian, branch (II) is closest to modern wolves from Sweden and Ukraine. One possible explanation is that dogs on this branch, which include the Norwegian Elkhound and the Jämthund, acquired their mitochondrial DNA from wild wolves in the recent past, after the advent of agriculture.

clearly both related to branch I European dogs, though the ages of the fossils (1,000 and 8,500 years BP respectively) mean that they must have arrived well before the first European settlement in the fifteenth century. These dogs accompanied the indigenous Native Americans who had arrived earlier from Asia. None, however, had mitochondrial DNA remotely like that from American wolves. This has to mean that Native American dogs were ultimately descended from European and not American wolves.

Moreover, we have had our particular affective chronometry (the time that it takes to calm down after getting upset) since we were kids. It’s part of our temperament. What does this mean for your love life? It is not an excuse to go full “Housewives of Wherever” on your partner because it’s just in your DNA.

CHAPTER 6 HOW DO YOU REPAIR EMF-RELATED DAMAGE? I know it may not feel like it at this point in the book, but there is good news here: Now that we have established how EMF exposure can damage your DNA through the peroxynitrite-induced creation of free radicals, we have a framework to remediate the damage. And there is even better news: Although there is no way your ancestral biology could have predicted the enormous exposure you would have to MHz and GHz radiation from the wireless industry, you do indeed have a built-in repair system that can at least partially remediate the damage. It is called the poly (ADP-ribose) polymerase (PARP) family of enzymes. (I know that is a mouthful, but this is a really important group of enzymes.) PARP1 is the most common in the family of 17 PARP enzymes and is best known for its ability to repair DNA damage., Note that in 2019 the PARP1 name was changed to ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1).1 PARP enzymes function as DNA damage sensors and signaling molecules. These enzymes bind to both single- and double-stranded DNA breaks.2

We look for ourselves in our family histories and in our genes, but such things alone do not make identity. We human beings are the meaning-makers, each of us a product of a particular time and place, with ideas about what we value and, indeed, what we hope to find when we look.

If whatever was on this island was indeed related to the alien ship, something might be wrong.  The ship, the hidden caves of alien DNA, even the green liquid they’d first discovered in Guyana all had the opposite effect.

Every evolutionary pathway is unique, and while all living beings are related, how each one came to be is a different story, with different pressures driving selection, and random changes in DNA providing the template from which variation, selection and evolutionary change can occur. Evolution is blind, mutation is random, selection is not.

Sleep deprivation even impacts DNA and learning-related genes in the brain involved in memory-making. Was that why other mothers didn’t talk about the reality of early motherhood or childbirth? Because they hadn’t made the memories?

Is it enough to live in a universe whose laws spontaneously create life? Or do you prefer ... God?” She paused, looking embarrassed. “Sorry, after all we’ve been through tonight, I know that’s a strange question.” “Well,” Langdon said with a laugh, “I think my answer would benefit from a decent night’s sleep. But no, it’s not strange. People ask me all the time if I believe in God.” “And how do you reply?” “I reply with the truth,” he said. “I tell them that, for me, the question of God lies in understanding the difference between codes and patterns.” Ambra glanced over. “I’m not sure I follow you.” “Codes and patterns are very different from each other,” Langdon said. “And a lot of people confuse the two. In my field, it’s crucial to understand their fundamental difference.” “That being?” Langdon stopped walking and turned to her. “A pattern is any distinctly organized sequence. Patterns occur everywhere in nature—the spiraling seeds of a sunflower, the hexagonal cells of a honeycomb, the circular ripples on a pond when a fish jumps, et cetera.” “Okay. And codes?” “Codes are special,” Langdon said, his tone rising. “Codes, by definition, must carry information. They must do more than simply form a pattern—codes must transmit data and convey meaning. Examples of codes include written language, musical notation, mathematical equations, computer language, and even simple symbols like the crucifix. All of these examples can transmit meaning or information in a way that spiraling sunflowers cannot.” Ambra grasped the concept, but not how it related to God. “The other difference between codes and patterns,” Langdon continued, “is that codes do not occur naturally in the world. Musical notation does not sprout from trees, and symbols do not draw themselves in the sand. Codes are the deliberate inventions of intelligent consciousnesses.” Ambra nodded. “So codes always have an intention or awareness behind them.” “Exactly. Codes don’t appear organically; they must be created.” Ambra studied him a long moment. “What about DNA?” A professorial smile appeared on Langdon’s lips. “Bingo,” he said. “The genetic code. That’s the paradox.” Ambra felt a rush of excitement. The genetic code obviously carried data — specific instructions on how to build organisms. By Langdon’s logic, that could mean only one thing. “You think DNA was created by an intelligence!” Langdon held up a hand in mock self-defense. “Easy, tiger!” he said, laughing. “You’re treading on dangerous ground. Let me just say this. Ever since I was a child, I’ve had the gut sense that there’s a consciousness behind the universe. When I witness the precision of mathematics, the reliability of physics, and the symmetries of the cosmos, I don’t feel like I’m observing cold science; I feel as if I’m seeing a living footprint ... the shadow of some greater force that is just beyond our grasp.

relatively small numbers of highly ordered particles, such as those inside a gene or the avian compass, can make a difference to an entire organism. This is what Jordan termed amplification and Schrödinger called order from order. The color of your eyes, the shape of your nose, aspects of your character, your level of intelligence and even your propensity to disease have in fact all been determined by precisely forty-six highly ordered supermolecules: the DNA chromosomes you inherited from your parents. No inanimate macroscopic object in the known universe has this sensitivity to the detailed structure of matter at its most fundamental level—a level where quantum mechanical rather than classical laws reign.

The solfeggio is a six-note scale and is also nicknamed “the creational scale.” Traditional Indian music calls this scale the saptak, or seven steps, and relates each note to a chakra. These six frequencies, and their related effects, are as follows: Do 396 Hz Liberating guilt and fear Re 417 Hz Undoing situations and facilitating change Mi 528 Hz Transformation and miracles (DNA repair) Fa 639 Hz Connecting/relationships Sol 741 Hz Awakening intuition La 852 Hz Returning to spiritual order Mi has actually been used by molecular biologists to repair genetic defects.115 Some researchers believe that sound governs the growth of the body. As Dr. Michael Isaacson and Scott Klimek teach in a sound healing class at Normandale College in Minneapolis, Dr. Alfred Tomatis believes that the ear’s first in utero function is to establish the growth of the rest of the body. Sound apparently feeds the electrical impulses that charge the neocortex. High-frequency sounds energize the brain, creating what Tomatis calls “charging sounds.”116 Low-frequency sounds drain energy and high-frequency sounds attract energy. Throughout all of life, sound regulates the sending and receiving of energy—even to the point of creating problems. People with attention deficit hyperactivity disorder listen too much with their bodies, processing sound through bone conduction rather than the ears. They are literally too “high in sound.”117 Some scientists go a step further and suggest that sound not only affects the body but also the DNA, actually stimulating the DNA to create information signals that spread throughout the body. Harvard-trained Dr. Leonard Horowitz has actually demonstrated that DNA emits and receives phonons and photons, the electromagnetic waves of sound and light. As well, three Nobel laureates in medical research have asserted that the primary function of DNA is not to synthesize proteins, but to perform bioacoustic and bioelectrical signaling.118 While research such as that by Dr. Popp shows that DNA is a biophoton emitter, other research suggests that sound actually originates light. In a paper entitled “A Holographic Concept of Reality,” which was featured in Stanley Krippner’s book Psychoenergetic Systems, a team of researchers led by Richard Miller showed that superposed coherent waves in the cells interact and form patterns first through sound, and secondly through light.119 This idea dovetails with research by Russian scientists Peter Gariaev and Vladimir Poponin, whose work with torsion energies was covered in Chapter 25. They demonstrated that chromosomes work like holographic biocomputers, using the DNA’s own electromagnetic radiation to generate and interpret spiraling waves of sound and light that run up and down the DNA ladder. Gariaev and his group used language frequencies such as words (which are sounds) to repair chromosomes damaged by X-rays. Gariaev thus concludes that life is electromagnetic rather than chemical and that DNA can be activated with linguistic expressions—or sounds—like an antenna. In turn, this activation modifies the human bioenergy fields, which transmit radio and light waves to bodily structures.120

Of course, it’s all imaginary, because I sure as shit did a DNA test to make sure we are, in fact, related by blood and genetics.

for Enoch, and for apocalyptic writers generally, there are not two worlds but one: or rather the whole of reality is split into matching pairs (rather like the biological theory of DNA) in which one half, the lower, is the mirror image (albeit in this case a distorting mirror) of the higher. That is why a revelation of what is above is not just relevant or related to what happens or is about to happen on earth: rather what happens on earth is a re-enactment in earthly terms of what has happened in heaven: a correspondence!

Processed oils like canola or vegetable oil are polyunsaturated fats, which are molecularly unstable and prone to cell-destroying oxidation. Oxidants are reactive molecules that are used to transfer electrons from one atom to another. They are naturally produced both inside your body and the environment, but in excess they can react with other cellular molecules in your body, such as proteins, DNA, and lipids, often contributing to disease and inflammation in the process. (This is why antioxidants are so important—they help prevent oxidation-related damage.)

The other side of this coin is that viruses may be genes who have broken loose from ‘colonies’ such as ourselves. Viruses consist of pure DNA (or a related self-replicating molecule) surrounded by a protein jacket. They are all parasitic.

fossils show that life started on earth around 3.5 billion years ago, relatively soon after the earth itself formed, and almost immediately after the planetary hydrosphere had cooled enough to support life. So there isn’t a whole lot of time for random chemical mixing to have produced so unlikely an outcome as complex, DNA-coded, living cells. Indeed, this would be on the order of suggesting that grains of sand on the seashore might combine by chance to form a five-storey building, complete with columns and corridors, or that various metal pieces might randomly come together to produce a functional automobile. Biologist

Now, scientists could reconstitute many more species by replacing the DNA of closely related creatures with DNA from extinct species.

If every chunk of DNA were halved with every generation, the result would be a rather neat picture of proportionately shrinking segments that matched an expanding fan of cousins. But if the cut and shuffle of DNA down through the generations is not a smooth, even process and relatively large chunks of DNA may be passed on through generations more or less unchanged, it has some interesting implications for what DNA can tell us about the past.

Butch Cassidy and Harry A. Longabaugh, “the Sundance kid,” were holed up and then gunned down Sixty years prior to the death of “Che” Guevara and high in the same Bolivian highlands, by the Bolivian army. It is thought that being mortally wounded one of them shot the other before shooting himself. Attempts to find any remains that match the DNA of living relatives, has so far failed. However, Butch Cassidy's sister, Lula Parker Betenson, maintained that her brother returned to the United States and lived in seclusion for years. In 1975, Red Fenwick, the feature writer and columnist at The Denver Post, stated that he was acquainted with Cassidy's physician, who continued to treat him for some years after he supposedly was killed in Bolivia. The likelihood of this account remains extremely doubtful. However, if it were true, Cassidy would certainly have died by now, and any opportunity to determine the truth would be difficult or perhaps even impossible. In addition, if true, it would raise the question of who the two men were that were killed by the Bolivian army…. The road between where the execution of “Che” Guevara took place and where Butch Cassidy and the Sundance kid were shot to death, is called El rastro de muerte or “The Trail of Death!

I stood straight and calm, though every part of me wanted to blast the crap out of the room. No one moved, no one spoke. I barely breathed. I didn’t know how much time had passed when Ty finally broke the silence. “If we’re demigods and you are demigods, which gods are our grandparents?” Tyde asked, snapping me out of my funk. Why hadn’t it occurred to me to ask that? My parents were the children of gods. All Mer were thought of as children of Poseidon in some respects, but this was different. “Well, your father’s father is Apollo,” Mom said, “And my father is… Zeus.” Whoa, that was big. Zeus was our grandfather. How does someone wrap their mind around that? “So our grandfathers are Apollo and Zeus, but aren’t they related? Wouldn’t that make you and Dad…” Ty couldn’t finish that thought and I was grateful. I was now grossed out. I couldn’t do the math on that messed up family tree. Yuck. “It doesn’t really work that way with the gods,” Mom said, catching on to what Ty was hinting at. “They are so ancient that their blood, while it will carry power, doesn’t carry much else in terms of genealogy. Our DNA comes mostly from our mortal parents. Our powers come from our godly parents but that’s it. It’s complicated, but your father and I are not related. So if you were worried… stop. You’re not the product of kissing cousins

It also incorporated the military philosophy of Col. John R. Boyd (USAF, ret.) and the reliance on the Marine Corps’ own former strategies and tactics found in its “Small Wars” DNA. 5 American history and its foreign relations helped to forge the Marine Corps into a military institution that has the unique characteristic of being the only waterborne fighting force in the American military experience. This can be seen in the very DNA of the Marine Corps from its inception and its concomitant history. In foreign actions, both bellicose and humanitarian, from the American Revolution to its present participation in the Global War on Terror, the Marine Corps has transformed itself into a force-in-readiness capable of employing maneuver-type tactics, casting aside the attritional defensive-offensive way of war.

But for now it’s goodbye to the beaches, and indeed many a celebrated island of yore now lies deep under the waves. An entire world and way of life has disappeared with these fabled places, a lifeway that went right back to the beginning of the species in south and east Africa, where the earliest humans were often intimately involved with the sea. That wet, sandy, tidal, salty, sun-flecked, beautiful beach life: all gone, along with so much else, of course; animals, plants, fish. It’s part of the mass extinction event they are still struggling to end, to escape. So much has been lost that will never come back again, that the loss of the joy of the relatively few humans who were lucky enough to live on the strand, who combed the beaches, and fished, and rode the waves, and lay in the sun – that’s nothing much to grieve for, given everything else that has been lost, all the suffering, all the hunger, all the death, all the extinctions. Most of the mammal species are gone. Still, it was a way of life much beloved, and still remembered in art and song, image and story – still legendary, still a lost golden age, vibrating at some level below thought, there in their salty blood and tears, in the long, curled waves of DNA that still break inside them all.

DNA analyses of modern people suggest that the human population declined dramatically, to perhaps only a few hundred. When we talk about all men and women being brothers and sisters, and people of all types being closely related, we are not just being poetic and romantic. Compared to other species, humans exhibit very little genetic diversity, a trait that stems back to that time, not too long ago, when a small band of survivors had to repopulate humanity. We

Sixty years prior to the death of “Che” Guevara and high in the same Bolivian highlands, Butch Cassidy and Harry A. Longabaugh, “the Sundance kid,” were holed up and then gunned down by the Bolivian army. It is thought that being mortally wounded, one of them shot the other before shooting himself. Attempts to find any remains that match the DNA of living relatives, has so far failed. However, Butch Cassidy's sister, Lula Parker Betenson, maintained that her brother returned to the United States and lived in seclusion for years. In 1975, Red Fenwick, the feature writer and columnist at The Denver Post, stated that he was acquainted with Cassidy's physician, who continued to treat him for some years after he supposedly was killed in Bolivia.

The town was relatively small. Beyond the sad side was a side maybe five years from going sad. Maybe more. Maybe ten. There was hope. There were some boarded-up enterprises, but not many. Most stores were still doing business, at a leisurely rural pace. Big pick-up trucks rolled through, slowly. There was a billiard hall. Not many street lights. It was getting dark. Something about the architecture made it clear it was dairy country. The shape of the stores looked like old-fashioned milking barns. The same DNA was in there somewhere.

In general, organisms that share very similar morphologies or similar DNA sequences are likely to be more closely related than organisms with vastly different structures or sequences. In some cases, however, the morphological divergence between related species can be great and their genetic divergence small (or vice versa). Consider the Hawaiian silversword plants discussed in Chapter 25. These species vary dramatically in appearance throughout the islands. Some are tall, twiggy trees, and others are dense, ground-hugging shrubs (see Figure 25.20). But despite these striking phenotypic differences, the silverswords’ genes are very similar. Based on these small molecular divergences, scientists estimate that the silversword group began to diverge 5 million years ago, which is also about the time when the oldest of the current islands formed. We’ll discuss how scientists use molecular data to estimate such divergence times later in this chapter.

If you let her tell it, she got family who ain’t blood and blood who ain’t family, and just because their DNA says they’re not related, doesn’t mean that’s true. If she had no one else in the world, she had Lyric, and that meant the world to her.

how each relates to all the others and to our health. I was reading Dancing Skeletons, a book by nutritional anthropologist Katherine Dettwyler about her time working in Africa, when I found a section about kwashiorkor. Kwashiorkor is a severe form of malnutrition common in young children throughout the tropics. The hallmark diet of this disease is high in calories (from sweet potatoes or other starches) but low in protein. In this case, the low protein is not the problem—other children who eat equally low amounts of protein but fewer total calories are not likely to develop the disease. It’s the ratio of the nutrients that contributes to the development of kwashiorkor. KEGEL EXERCISE A contraction of the pelvic floor often prescribed to prevent the leakage of urine when coughing or running. This section of Dettwyler’s book resonated with me because I recognize that the outcomes of an exercise program depend largely on the ratio of all the movements to each other. Exercise (a repetitive intake of an isolated muscle contraction to fill a hole of missing strength) is often prescribed like vitamins (a capsule ingested to decrease a nutritional void). One of the arguments I am most known for professionally is that the way the Kegel exercise is prescribed can actually be harmful and not helpful at all. A Kegel is like a starch in the case of kwashiorkor: when done excessively and in the absence of other movement vitamins, it can create a negative outcome—too much pelvic-floor tension. The Kegel (as I’ll expand upon in Chapter 10) is not inherently more “bad” than a sweet potato, but neither is a sweet potato (or Kegel) health-making when consumed in isolation.

Another issue is more intellectually intriguing, and goes to the heart of DNA’s power. What about the rights of relatives to privacy? The genotyping of someone under arrest could be considered a reasonable search of that person,

it is not uncommon for experts in DNA analysis to testify at a criminal trial that a DNA sample taken from a crime scene matches that taken from a suspect. How certain are such matches? When DNA evidence was first introduced, a number of experts testified that false positives are impossible in DNA testing. Today DNA experts regularly testify that the odds of a random person’s matching the crime sample are less than 1 in 1 million or 1 in 1 billion. With those odds one could hardly blame a juror for thinking, throw away the key. But there is another statistic that is often not presented to the jury, one having to do with the fact that labs make errors, for instance, in collecting or handling a sample, by accidentally mixing or swapping samples, or by misinterpreting or incorrectly reporting results. Each of these errors is rare but not nearly as rare as a random match. The Philadelphia City Crime Laboratory, for instance, admitted that it had swapped the reference sample of the defendant and the victim in a rape case, and a testing firm called Cellmark Diagnostics admitted a similar error.20 Unfortunately, the power of statistics relating to DNA presented in court is such that in Oklahoma a court sentenced a man named Timothy Durham to more than 3,100 years in prison even though eleven witnesses had placed him in another state at the time of the crime. It turned out that in the initial analysis the lab had failed to completely separate the DNA of the rapist and that of the victim in the fluid they tested, and the combination of the victim’s and the rapist’s DNA produced a positive result when compared with Durham’s. A later retest turned up the error, and Durham was released after spending nearly four years in prison.21 Estimates of the error rate due to human causes vary, but many experts put it at around 1 percent. However, since the error rate of many labs has never been measured, courts often do not allow testimony on this overall statistic. Even if courts did allow testimony regarding false positives, how would jurors assess it? Most jurors assume that given the two types of error—the 1 in 1 billion accidental match and the 1 in 100 lab-error match—the overall error rate must be somewhere in between, say 1 in 500 million, which is still for most jurors beyond a reasonable doubt. But employing the laws of probability, we find a much different answer. The way to think of it is this: Since both errors are very unlikely, we can ignore the possibility that there is both an accidental match and a lab error. Therefore, we seek the probability that one error or the other occurred. That is given by our sum rule: it is the probability of a lab error (1 in 100) + the probability of an accidental match (1 in 1 billion). Since the latter is 10 million times smaller than the former, to a very good approximation the chance of both errors is the same as the chance of the more probable error—that is, the chances are 1 in 100. Given both possible causes, therefore, we should ignore the fancy expert testimony about the odds of accidental matches and focus instead on the much higher laboratory error rate—the very data courts often do not allow attorneys to present! And so the oft-repeated claims of DNA infallibility are exaggerated.

The discovery that Father Sánchez’s paternal line is haplogroup J1 is somewhat surprising, as Spain has no large population group from within that subhaplogroup—in fact, only about 7 percent of the Spanish population tests as J1. Given the relatively small percentage of this lineage in the rest of Europe, it can safely be assumed that many J1’s from Spain share a crypto-Judaic past, which is probably true of Father Sánchez. It is also interesting to note that the signature of the Cohanim—descendants of Jewish priests—is also found in haplogroup J1.

However, with improvements in medical knowledge will come new ethical conundrums. Ethicists and legal experts are already wrestling with the thorny issue of privacy as it relates to DNA. Would insurance companies be entitled to ask for our DNA scans and to raise premiums if they discover a genetic tendency to reckless behaviour? Would we be required to fax our DNA, rather than our CV, to potential employers? Could an employer favour a candidate because his DNA looks better? Or could we sue in such cases for ‘genetic discrimination’? Could a company that develops a new creature or a new organ register a patent on its DNA sequences? It is obvious that one can own a particular chicken, but can one own an entire species?

It just so happened that all the psychics were older women. We then found controls who did not have any psychic abilities or family members with those abilities. Because we were looking at genetics, the controls’ demographic characteristics of age, gender, and race had to match our psychics’ demographics so that any differences we saw between the two groups were not a result of those aspects. For example, we had to find controls who were older women to match the older age and gender of the psychics. It took us a much longer time to find the controls. Apparently, it is challenging to find older women with no psychic abilities. We finally collected saliva from all the participants to extract the DNA and decoded all their genes. We compared the gene sequences of the psychics to the controls. Much to our surprise, we found one section of the noncoding DNA that was conserved, or wild-type, in all the psychics but was variable in the controls. Wild-type means that the DNA sequence was the original version and was not mutated. That it was in a noncoding region of the DNA means that it was in a part that does not code for a protein. Instead, it likely acts to regulate the activity levels of its neighboring gene. The gene next to it is highly expressed in the brain. This supports the notion that this conserved region could influence gene activity related to psychic abilities (Wahbeh, Radin, et al. 2021).

Creatures with bodies—animals, plants, and fungi—are relative newcomers to the planet, and they are all composed of cells derived from the merger of different individuals.

Social ecologist Gregory Bateson foresaw how the separating of mind from matter – spirit from nature – creates all sorts of problems. For Bateson, this separation is an error of the most fundamental degree. This error, Bateson saw woven into Western habits of thought at deep and partly unconscious levels, undermining our capacity to flourish sustainably on Earth. He felt that it is what pits humanity against nature and provides for our prevalent worldview of survival through competition, in what he viewed as “an ecology of bad ideas” breeding parasitic humans, purely self-centered and destructive of their host environment. He noted that if you, “see the world around you as mindless and therefore not entitled to moral or ethical consideration, the environment will be yours to exploit…If this is your estimate of your relation to nature and you have an advanced technology, your likelihood of survival will be that of a snowball in hell. You will die either of the toxic by-products of your own hate, or, simply, of over-population and over-grazing” (Bateson, 2000).

When Richard Cooper went to medical school at the University of Arkansas in the late 1960s, he was stunned at how many of his black patients were suffering from high blood pressure. He would encounter people in their forties and fifties felled by strokes that left them institutionalized. When Cooper did some research on the problem, he learned that American doctors had first noted the high rate of hypertension in American blacks decades earlier. Cardiologists concluded it must be the result of genetic differences between blacks and whites. Paul Dudley White, the preeminent American cardiologist of the early 1900s, called it a “racial predisposition,” speculating that the relatives of American blacks in West Africa must suffer from high blood pressure as well. Cooper went on to become a cardiologist himself, conducting a series of epidemiological studies on heart disease. In the 1990s, he finally got the opportunity to put the racial predisposition hypothesis to the test. Collaborating with an international network of doctors, Cooper measured the blood pressure of eleven thousand people. Paul Dudley White, it turned out, was wrong. Farmers in rural Nigeria and Cameroon actually had substantially lower blood pressure than American blacks, Cooper found. In fact, they had lower blood pressure than white Americans, too. Most surprisingly of all, Cooper found that people in Finland, Germany, and Spain had higher blood pressure than American blacks. Cooper’s findings don’t challenge the fact that genetic variants can increase people’s risk of developing high blood pressure. In fact, Cooper himself has helped run studies that have revealed some variants in African Americans and Nigerians that can raise that risk. But this genetic inheritance does not, on its own, explain the experiences of African and European Americans. To understand their differences, doctors need to examine the experiences of blacks and whites in the United States—the stress of life in high-crime neighborhoods and the difficulty of getting good health care, for example. These are powerful inheritances, too, but they’re not inscribed in DNA. For scientists carrying out the hard work of disentangling these influences, an outmoded biological concept of race offers no help. In the words of the geneticists Noah Rosenberg and Michael Edge, it has become “a sideshow and a distraction.

Oxidation burns things gradually and steadily. Just as oxidation causes metal to rust and apple flesh to brown, it damages cells throughout the body by zapping DNA, scarring the walls of arteries, inactivating enzymes, and mangling proteins. Paradoxically, the more oxygen we use, the more we generate reactive oxygen species, so theoretically vigorous physical activities that consume lots of oxygen should accelerate senescence. A related driver of senescence is mitochondrial dysfunction. Mitochondria are the tiny power plants in cells that burn fuel with oxygen to generate energy (ATP). Cells in energy-hungry organs like muscles, the liver, and the brain can have thousands of mitochondria. Because mitochondria have their own DNA, they also play a role in regulating cell function, and they produce proteins that help protect against diseases like diabetes and cancer.29 Mitochondria, however, burn oxygen, creating reactive oxygen species that, unchecked, cause self-inflicted damage. When mitochondria cease to function properly or dwindle in number, they cause senescence and illness.30

Ancestral DNA research suggests that when the last real Viking died in an attack on Dublin in 1171, his marker carried on – with great vigour. A relatively new sub-type of M17 – S375 – is now prominent in the North Isles of Orkney, on the five major islands north of Gairsay. It is also carried by 30 per cent of men with the surname of Gunn who have taken DNA tests. Tradition, genealogy and history all begin to come together to form a narrative. It may be that the prevalence of S375 on the islands of Rousay, Westray, Eday, Sanday and Stronsay is linked to the well-attested phenomenon of social selection, where powerful men in the past sired many children with different women. In that way their Y chromosome markers were spread widely and quickly, much faster than if they had remained monogamous. And few men were more powerful in 12th-century Orkney than Svein Asleifsson.